@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : VGLU2_HUMAN: (2015-12-12 )
MESVKQRILAPGKEGLKNFAGKSLGQIYRVLEKKQDTGETIELTEDGKPLEVPERKAPLCDCTCFGLPRRYIIAIMSGLGFCISFGIRCNLGVAIVDMVNNSTIHRGGKVIKEKAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVWYMFWLLVSYESPAKHPTITDEERRYIEESIGESANLLGAMEKFKTPWRKFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQILSTTTVRKIMNCGGFGMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKNKSREEWQYVFLIAALVHYGGVIFYAIFASGEKQPWADPEETSEEKCGFIHEDELDEETGDITQNYINYGTTKSYGATTQANGGWPSGWEKKEEFVQGEVQDSHSYKDRVDYS
Atome Classification :
(20 SA)
.........10........20........30...-.....40........------50........60........70........80-........90........100...--------------....110.......120.......130-----------........140.---......--150......---.160---.......170.--..--.-...180.......190...----......200.......210.-....-------..220....-...230......--------------------------.240........250-.........260.-......270.......280.......290.......300..-......310.......320.......330.......340---........---350.....---..360.......370.......380.......390.......400....--.---..410..-.-....420......-.-430.......440.......-450-......-.460---.......470...-....480.......490.......--500.......510-------........520.......530.......540------.......550.......560.......570.......580
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
ME
S
V
K
Q
R
I
LAP
G
K
E
G
L
K
N
F
A
G
K
S
L
G
Q
I
Y
R
V
L
E
KK-QDTG
E
T
I
E
LTEDGKP------LEVPERKAPLCDCTCFGL
P
R
R
Y
I
I
A
I
M
S
G
L
G
F
-
C
I
S
FGIRCNL
G
V
A
I
V
DMVNNSTIH--------------RG
G
K
V
I
K
E
KAKFNWDPE
T
V
G
M
I
H
G
S
F
------------
F
W
G
Y
I
I
T
QIP
G
G
---
Y
I
A
S
R
L
--
A
A
N
R
V
F
G
A
A
---
I
L
L
T
---
S
T
L
N
M
LIPSAA--R
V
--
H
-
Y
G
C
V
I
F
V
R
I
L
Q
G
L
V--EGV----T
Y
P
A
C
H
G
I
W
S
KWAP
P
L
E
R
SR-L
A
T
T
-------
S
F
C
G
S
YA
G
A
-
V
I
A
M
P
L
A
G
I
L
V
Q
--------------------------YTG-W
S
S
V
F
Y
V
YG---
S
F
G
M
V
W
Y
M
F
W
L
L
V-SYESPAKHPTI
T
D
E
E
R
R
Y
I
E
E
S
IG
E
S
A
N
L
L
G
A
M
E
K
FK
T
-
P
W
-
R
K
F
F
TSM
P
V
Y
A
I
I
V
A
N
F
C
R
S
W
T
F
Y
L
L
L
ISQ
P
A
Y
F
E
E
V
-F---GF
E
I
S
KV
G
---
M
L
S
A
V
P
H
L
---
V
M
T
I
IVPIG
G
Q
I
A
D
F
L
R
SKQ
I
L
S
T
T
T
V
R
K
I
M
NCGGFG
M
E
A
T
L
L
L
V
V
GYS--H---TR
G
V
A
I
S
-
F
-
L
V
L
A
VGFS
G
F
A
I
S-G-F
N
V
N
H
LDI
A
P
R
Y
A
S
I
L
M
G
IS-N
G
V
-
G
T
LSG
M
-
V
C
P
I
---
I
V
G
AMTKNKSR
E
E
-
W
Q
Y
V
F
L
I
A
A
L
V
HYG
G
V
I
F
Y
A
I
FAS--GEKQPWADPEET--------SEEKCGFIHE
D
E
LDEET
G
D
I
T
Q
N
Y
INYGTTK------SYGATTQANGGWPS
G
W
E
K
K
E
E
F
VQGEVQDSHSYKDRVDYS
5
Fugue
84.22
13%
-107
- C3 -
1PW4
-
GLPT_ECOLI
A:
[5-451]
F
K
P
A
P
H
K
A
R
L
P
A
A
E
I
------------------------------------------------------
D
P
T
Y
R
R
L
R
W
Q
I
F
L
G
I
F
F
G
Y
-
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
L
------------------------------
V
E
Q
G
F
S
R
G
D
L
G
F
A
L
S
G
I
------------
S
I
A
Y
G
F
S
K
F
I
M
G
---
S
V
S
D
R
S
--
N
P
R
V
F
L
P
A
G
---
L
I
L
A
---
A
A
V
M
L
F
M
G
F
V
P
--
W
A
T
S
S
-
I
A
V
M
F
V
L
L
F
L
C
G
W
F
--
Q
G
M
----
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
R
G
G
-
I
V
S
V
-------
W
N
C
A
H
N
V
G
G
-
G
I
P
P
L
L
F
L
L
G
M
A
--------------------------
W
F
N
D
W
H
A
A
L
Y
M
P
A
---
F
C
A
I
L
V
A
L
F
A
F
A
M
-
M
R
D
T
P
Q
S
C
G
L
P
P
I
E
E
Y
K
N
D
T
A
K
--------------
Q
I
-
F
M
-
Q
Y
V
L
P
N
K
L
L
W
Y
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
W
S
P
T
Y
L
K
E
V
-
K
---
H
F
A
L
D
K
S
S
---
W
A
Y
F
L
Y
E
Y
---
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
----
N
R
G
A
T
G
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
W
M
N
P
A
G
--
N
---
P
T
V
D
M
I
C
-
M
-
I
V
I
G
F
L
I
Y
G
P
V
M
L
-
I
-
G
L
H
A
L
E
L
A
P
K
K
A
A
G
T
A
A
G
F
T
-
G
L
F
-
G
Y
L
G
G
S
-
V
A
A
S
---
A
I
V
G
Y
T
V
D
F
F
G
W
D
-
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
--
K
R
R
H
E
Q
L
L
Q
E
L
V
--------
P
----------------------------------------------------------------------------
14
HHSearch
82.43
15%
-125
- C3 -
1PW4
-
GLPT_ECOLI
A:
[24-435]
-------------------------------------------------------------------------
R
R
L
R
W
Q
I
F
L
G
I
F
F
G
Y
-
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
L
-----------------------------
V
-
E
Q
G
F
S
R
G
D
L
G
F
A
L
S
G
I
------------
S
I
A
Y
G
F
S
K
F
I
M
G
---
S
V
S
D
R
S
--
N
P
R
V
F
L
P
A
G
---
L
I
L
A
---
A
A
V
M
L
F
M
G
F
V
P
W
A
T
S
--
S
-
I
A
V
M
F
V
L
L
F
L
C
G
W
F
--
Q
G
M
----
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
R
G
G
-
I
V
S
V
-------
W
N
C
A
H
N
V
G
G
-
G
I
P
P
L
L
F
L
L
G
M
A
W-------------------------
F
N
D
-
W
H
A
A
L
Y
M
P
A
---
F
C
A
I
L
V
A
L
F
A
F
A
M
-
M
R
D
T
P
Q
S
C
G
L
P
P
I
E
E
Y
K
N
D
---------------
T
A
K
Q
I
F
M
-
Q
Y
V
L
P
N
K
L
L
W
Y
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
W
S
P
T
Y
L
K
E
V
-
K
---
H
F
A
L
D
K
S
S
---
W
A
Y
F
L
Y
E
Y
---
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
R
G
A
T
------
G
-
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
W
M
N
PA
G
---
N
P
T
V
D
M
I
C
M
-
I
V
I
G
F
L
I
Y
G
P
V
M
L
-
I
-
G
L
H
A
L
E
L
A
P
K
K
A
A
G
T
A
A
G
F
T
-
G
L
F
-
G
Y
L
G
G
S
V
A
A
S
A
---
I
V
G
Y
T
V
D
F
---
F
G
-
W
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
--
G
E
K
R
R
H
E
Q
L
L
Q
E
--------
L
V
P
--------------------------------------------------------------------------
10
Fugue
80.58
17%
-102
- C1 -
4Q86
1
YCAO_ECOLI
A:
[2-583]
-----
T
Q
T
F
I
P
G
K
D
-------
A
A
L
E
D
S
I
A
R
F
Q
Q
K
L
S
D
L
G
F
Q
I
E
E
A
S
W
L
N
P
VPN
V
W
S
V
H
I
R
D
K
E
C
A
L
C
F
T
N
G
K
G
A
T
K
K
A
A
L
A
S
A
L
G
E
Y
F
E
R
L
S
T
N
Y
F
F
A
D
F
W
L
G
E
T
I
A
N
G
P
F
V
H
YPN
E
K
W
F
P
L
TENDD
V
P
E
G
L
L
D
D
R
L
R
A
F
Y
D
P
E
--
N
E
L
T
G
S
M
LIDLQSGNEDR
G
I
C
G
L
P
F
T
R
Q
S
D
N
Q
T
V
Y
I
P
M
N
I
--
I
G
N
L
Y
V
S
N
G
---
M
S
A
G
---
N
T
-----
R
N
E
A
--
R
V
--
Q
-
G
L
S
E
V
F
E
R
Y
V
K
N
R
I
I
A
E
S
I
----
S
L
P
E
I
P
A
D
V
L
A
R
Y
P
A
V
V
E
A
I
-
E
T
L
E
A
E
G
F
P
I
F
A
Y
D
G
S
L
G
G
Q
----
Y
P
V
I
C
V
V
L
F
--------------------------
N
P
A
-
N
G
T
C
F
A
S
F
G
A
H
P
D
F
G
V
A
L
E
R
T
V
T
E
L
-
L
Q
G
R
G
L
K
D
L
D
V
F
-
T
P
P
T
F
D
D
E
E
V
A
E
H
T
N
L
E
T
H
F
I
D
S
S
G
-
L
I
S
W
D
L
F
K
Q
D
A
D
Y
P
F
V
------
D
W
N
F
S
G
T
T
E
E
E
F
A
T
L
M
A
I
-
F
---
N
K
E
D
K
E
V
----
Y
I
A
D
Y
E
H
L
G
V
Y
A
C
R
I
I
V
P
---
G
M
S
D
I
Y
P
A
E
D
L
W
L
A
N
------
N
S
M
G
S
H
L
R
E
T
I
L
S
L
P
G
-
S
--
E
---
W
E
K
E
D
Y
L
-
N
-
L
I
E
Q
L
D
E
E
G
F
D
D
F
-
T
-
R
V
R
E
L
L
G
L
A
T
G
S
D
N
G
W
Y
T
L
R
---
I
-
G
E
L
K
A
M
-
L
A
L
A
G
GD
L
E
Q
A
L
V
W
T
E
W
T
M
E
-
F
N
S
S
V
F
S
P
E
R
A
N
Y
Y
R
C
L
Q
T
L
L
L
L
A
--
Q
E
E
D
R
--
Q
P
L
Q
Y
--------
L
N
A
F
V
R
M
Y
G
A
D
A
V
E
A
A
S
A
A
M
S
G
E
A
A
F
Y
G
L
Q
P
VDSDLH
A
F
A
A
H
Q
S
L
L
K
A
Y
E
K
L
Q
R
A
K
A
A
F
------------------
6
Fugue
68.19
10%
-104
- C3 -
1PV6
-
LACY_ECOLI
A:
[1-417]
M
Y
Y
L
K
N
---------------------------------------------------------------------
T
N
F
W
M
F
G
L
F
F
F
F
Y
-
F
F
I
M
G
A
Y
F
P
F
F
P
I
W
L
H
D
I
N
H
I
S
-------------------------------
K
S
D
T
G
I
I
F
A
A
I
------------
S
L
F
S
L
L
F
Q
P
L
F
G
---
L
L
S
D
K
L
GL
R
K
Y
L
L
W
I
I
T
---
G
M
L
V
---
M
F
A
P
F
F
I
F
I
F
G
--
P
L
--
L
-
Q
Y
N
I
L
V
G
S
I
V
G
G
I
Y
--
L
G
F
----
C
F
N
A
G
A
P
A
V
E
A
F
I
E
K
V
S
R
R
S
N
F
E
F
G
-------
R
A
R
M
F
G
C
V
G
-
W
A
L
G
A
S
I
V
G
I
M
F
--------------------------
T
I
N
-
N
Q
F
V
F
W
L
G
S
---
G
C
A
L
I
L
A
V
L
L
F
F
A
-
K
T
D
A
P
S
S
A
T
V
A
N
A
V
G
A
N
H
S
A
F
S
L
K
L
A
L
E
L
F
R
Q
----------
P
K
L
W
F
L
S
L
Y
V
I
G
V
S
C
T
Y
D
V
F
D
Q
Q
F
A
N
F
F
T
S
F
F
A
T
G
E
Q
-
G
---
T
R
V
F
G
Y
V
T
---
T
M
G
E
L
L
N
A
---
S
I
M
------------
F
F
A
P
L
I
I
N
R
I
G
G
K
N
A
L
L
L
A
G
T
I
M
S
V
R
I
I
G
S
S
F
A
T
--
S
---
A
L
E
V
V
I
L
-
K
-
T
L
H
M
F
E
V
P
F
L
L
V
G
-
C
-
F
K
Y
I
T
S
Q
F
E
V
R
F
S
A
T
I
Y
L
V
C
-
F
C
F
F
K
Q
L
A
M
I
-
F
M
S
V
---
L
A
G
N
M
Y
E
S
I
G
----
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
--
G
P
G
P
L
S
L
L
R
R
Q
V
--------
N
E
V
A
-------------------------------------------------------------------------
18
HHSearch
64.61
12%
-100
* C3 *
2CFQ
-
LACY_ECOLI
A:
[35-396]
---------------------------------------------------------------------------------------------------------------------------------------
H
D
I
N
H
I
S
K
S
D
T
G
I
I
F
A
A
I
------------
S
L
F
S
L
L
F
Q
P
L
F
G
---
L
L
S
D
K
L
--
G
L
R
K
Y
L
L
W
I
I
T
G
M
L
V
M
---
F
A
P
F
F
I
F
I
F
G
----
P
--
L
L
Q
Y
N
I
L
V
G
S
I
V
G
G
I
Y
--
L
G
F
CFNA
G
A
P
A
V
E
A
F
I
E
K
V
S
R
--
R
S
N
F
-
E
F
G
R
-------
A
R
M
F
G
C
V
G
W
-
A
L
G
A
S
I
V
G
I
M
F
T
---------------------------
I
N
-
N
Q
F
V
F
W
L
G
S
---
G
C
A
L
I
L
A
V
L
L
F
F
A
-
K
T
D
A
P
S
S
A
T
V
A
N
A
V
G
A
--------------
N
H
S
A
F
S
L
K
-
L
A
-
L
E
L
F
R
Q
P
K
L
W
F
L
S
L
Y
V
I
G
V
S
C
T
Y
D
V
F
D
Q
Q
F
A
N
F
F
T
S
F
-
F
AT
G
E
Q
G
T
R
V
F
G
---
Y
V
T
T
M
G
E
L
---
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
G
G
K
N
A
L
L
----------
L
A
G
T
I
M
S
V
R
I
I
G
S
S
F
A
--
T
---
S
A
L
E
V
V
I
-
L
-
K
T
L
H
M
F
E
V
P
F
L
L
V
G
C
-
F
K
Y
I
T
S
Q
F
E
V
R
F
S
A
T
I
Y
L
V
C
F
C
F
F
-
K
Q
L
A
M
I
-
F
M
S
V
---
L
A
G
N
M
Y
E
S
---
I
G
-
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
--
G
P
G
P
L
S
L
L
R
R
Q
V
--------
N
E
V
A
-------------------------------------------------------------------------
15
HHSearch
63.73
13%
-114
- C3 -
3O7Q
1
FUCP_ECOLI
A:
[34-421]
--------------------------------------------------------------------------------------
L
F
-
F
L
W
A
V
A
N
N
L
N
D
I
L
L
P
Q
F
-----------------------------
Q
Q
A
F
T
L
T
N
F
Q
A
G
L
I
Q
S
A
F
------------
Y
F
G
Y
F
I
I
P
I
P
A
G
---
I
L
M
K
K
L
--
S
Y
K
A
G
I
I
T
G
---
L
F
L
Y
---
A
L
G
A
A
L
F
W
P
A
A
E
-
I
M
--
N
-
Y
T
L
F
L
V
G
L
F
I
I
A
A
G
--
L
G
C
----
L
E
T
A
A
N
P
F
V
T
V
L
G
P
E
S
S
G
H
F
-
R
L
N
L
-------
A
Q
T
F
N
S
F
G
A
-
I
I
A
V
V
F
G
Q
S
L
I
L
SNVPHQS
Q
D
V
L
D
K
MS
P
E
Q
L
S
A
Y
K
H
S
L
V
L
S
-
V
Q
T
P
Y
M
I
I
V
---
A
I
V
L
L
V
A
L
L
I
M
L
T
K
F
P
A
L
Q
S
---
D
N
H
S
D
A
----------------
K
Q
G
S
F
S
A
-
S
L
-
S
R
L
A
R
I
R
H
W
R
W
A
V
L
A
Q
F
C
Y
V
G
A
Q
T
A
C
W
S
Y
L
I
R
Y
A
V
E
E
I
P
---
G
M
T
A
G
F
A
A
---
N
Y
L
T
G
T
M
V
---
C
F
F
I
G
R
F
T
G
T
W
L
I
S
R
F
A
P
H
K
V
L
A
A
----------
Y
A
L
I
A
M
A
L
C
L
I
S
A
F
A
--
G
---
G
H
V
G
L
I
A
-
L
-
T
L
C
S
A
F
-
M
S
I
Q
Y
P
T
I
-
F
S
L
G
I
K
N
L
G
Q
D
T
-
K
Y
G
S
S
F
I
--
V
M
-
T
I
I
G
G
G
-
I
V
T
P
---
V
M
G
F
V
S
D
A
---
A
G
N
I
P
T
A
E
L
I
P
A
L
C
F
A
V
I
F
I
F
A
R
F
R
S
Q
--
T
------------------------------------------------------------------------------------------------
16
HHSearch
60.39
14%
-112
- C3 -
3WDO
-
?
A:
[38-381]
---------------------------------------------------------------------------------------------------------------------------------------
M
A
L
Q
G
A
S
E
A
L
I
G
I
A
I
G
I
Y
------------
G
L
T
Q
A
V
F
Q
I
P
F
G
---
L
L
S
D
R
I
--
G
R
K
P
L
I
V
G
G
---
L
A
V
F
---
A
A
G
S
V
I
A
A
L
S
----
D
--
S
-
I
W
G
I
I
L
G
R
A
L
Q
G
S
G
--
A
------
I
A
A
A
V
M
A
L
L
S
D
L
T
R
E
Q
N
R
T
K
-
A
M
A
F
-------
I
G
V
S
F
G
I
T
F
-
A
I
A
M
V
L
G
P
I
I
T
H
--------------------------
K
L
G
-
L
H
A
L
F
W
M
I
A
---
I
L
A
T
T
G
I
A
L
T
I
W
V
-
V
P
N
S
S
T
H
V
L
N
R
E
--------------------
S
G
M
V
K
G
-
S
F
-
S
K
V
L
A
E
P
R
L
L
K
L
N
F
G
I
M
C
L
H
M
L
L
M
S
T
F
V
A
L
P
G
Q
L
A
D
--
A
---
G
F
P
A
A
E
H
W
K
V
Y
L
A
T
M
L
I
A
F
---
G
S
V
V
P
F
I
I
Y
A
E
V
K
R
K
M
K
Q
V
F
V
F
----------
C
V
G
L
I
V
V
A
-
E
I
V
L
W
N
A
Q
--
T
---
Q
F
W
Q
L
V
V
-
G
V
Q
L
F
F
V
A
-
F
N
L
M
E
A
L
L
-
P
S
L
I
S
K
E
S
P
A
G
Y
K
G
T
A
M
G
V
Y
-
S
T
S
-
Q
F
L
G
V
A
-
I
G
G
S
---
L
G
G
W
I
D
G
M
---
F
D
-
G
Q
G
V
F
L
A
G
A
M
L
A
A
V
W
L
A
V
A
S
T
M
K
E
--
P
P
Y
V
S
S
L
R
I
E
I
P
--------
A
D
I
A
A
N
E
A
L
K
V
R
L
L
E
T
E
G
V
K
E
V
L
I
A
E
E
E
H
S
A
------
Y
V
K
I
D
S
K
V
T
N
R
F
E
V
E
Q
A
I
R
Q
A
L
------------------
12
Fugue
58.32
10%
-75
- C3 -
2GFP
-
EMRD_ECOLI
A:
[9-383]
-----------------------------------------------------------------------------------------------
L
L
L
M
L
V
L
L
V
A
V
G
Q
M
A
Q
T
I
--------------
Y
I
P
A
I
A
D
M
A
R
D
L
N
V
R
E
G
A
V
Q
S
V
M
G
A
Y
------------
L
L
T
Y
G
V
S
Q
L
F
Y
G
---
P
I
S
D
R
V
--
G
R
R
P
V
I
L
V
G
---
M
S
I
F
---
M
L
A
T
L
V
A
V
T
T
S
--
S
L
--
T
-
V
--
L
I
A
A
S
A
M
Q
G
M
G
--
T
G
V
----
G
G
V
M
A
R
T
L
P
R
D
L
Y
E
R
T
Q
L
R
H
-
A
N
S
L
-------
L
N
M
G
I
L
V
S
P
-
L
L
A
P
L
I
G
G
L
L
D
T
--------------------------
M
W
N
-
W
R
A
C
Y
L
F
L
L
---
V
L
C
A
G
V
T
F
S
M
A
R
W
-
M
P
E
T
R
P
V
D
A
P
R
T
R
L
L
T
S
Y
------------------------
K
T
L
F
G
N
S
G
F
N
C
Y
L
L
M
L
I
G
G
L
A
G
I
A
A
F
E
A
C
S
G
V
L
M
G
A
V
-
L
---
G
L
S
S
M
T
V
S
---
I
L
F
I
L
P
I
P
---
A
A
F
F
G
A
W
F
A
G
R
P
N
K
R
F
S
T
L
M
W
Q
S
V
I
C
C
L
L
-------
A
G
L
L
M
W
I
P
D
W
F
G
V
--
M
---
N
V
W
T
L
L
V
-
P
-
A
A
L
F
F
F
G
A
G
M
L
F
P
-
L
-
A
T
S
G
A
M
E
P
F
P
F
L
A
G
T
A
G
A
L
V
-
G
G
L
-
Q
N
I
G
S
G
-
V
L
A
S
---
L
S
A
M
L
P
Q
T
G
Q
G
S
L
-
G
L
L
M
T
L
M
G
L
L
I
V
L
C
W
L
P
L
---------------------------------------------------------------------------------------------------------
17
HHSearch
54.35
11%
-83
- C3 -
2GFP
-
EMRD_ECOLI
A:
[32-360]
------------------------------------------------------------------------------------------------------------------------------------
A
D
M
A
R
D
L
N
V
R
E
G
A
V
Q
S
V
M
G
A
Y
------------
L
L
T
Y
G
V
S
Q
L
F
Y
G
---
P
I
S
D
R
V
--
G
R
R
P
V
I
L
V
G
---
M
S
I
F
---
M
L
A
T
L
V
A
V
T
T
----
S
--
S
-
L
T
V
L
I
A
A
S
A
M
Q
G
M
G
--
T
G
V
----
G
G
V
M
A
R
T
L
P
R
D
L
Y
E
R
T
Q
L
R
H
-
A
N
S
L
-------
L
N
M
G
I
L
V
S
P
-
L
L
A
P
L
I
G
G
L
L
D
T
--------------------------
M
W
N
-
W
R
A
C
Y
L
F
L
L
---
V
L
C
A
G
V
T
F
S
M
A
R
W
-
M
P
E
T
R
P
V
D
A
P
----------------------
R
T
R
L
L
T
-
S
Y
-
K
T
L
F
G
N
S
G
F
N
C
Y
L
L
M
L
I
G
G
L
A
G
I
A
A
F
E
A
C
S
G
V
L
M
G
A
V
-
L
---
G
L
S
S
M
T
V
S
---
I
L
F
I
L
P
I
P
---
A
A
F
F
G
A
W
F
A
G
R
P
N
K
R
F
S
T
L
M
W
Q
S
---------
V
I
C
C
L
L
A
G
L
L
M
W
I
P
D
W
F
G
V
M
---
N
V
W
T
L
L
V
-
P
-
A
A
L
F
F
F
G
A
G
M
L
F
P
-
L
-
A
T
S
G
A
M
E
P
F
P
F
L
A
G
T
A
G
A
L
V
-
G
G
L
-
Q
N
I
G
S
G
-
V
L
A
S
---
L
S
A
M
L
P
Q
T
G
Q
G
S
L
-
G
L
L
M
T
L
M
G
L
L
I
V
L
C
W
L
P
L
---------------------------------------------------------------------------------------------------------
19
HHSearch
50.53
12%
-119
- C3 -
3WDO
-
?
A:
[11-180]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
W
G
L
G
T
V
F
S
L
R
M
L
G
M
F
M
V
L
P
V
L
T
T
Y
G
M
A
L
-
Q
---
G
A
S
E
A
L
I
G
---
I
A
I
G
I
Y
G
L
---
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
I
G
R
K
P
L
I
V
----------
G
G
L
A
V
F
A
A
G
S
V
I
A
A
L
S
--
D
---
S
I
W
G
I
I
L
-
G
R
A
L
Q
G
S
G
--
A
I
A
A
A
-
V
-
M
A
L
L
S
D
L
T
R
E
Q
N
R
T
K
A
M
A
F
I
-
G
V
S
-
F
G
I
T
F
A
-
I
A
M
V
---
L
G
P
I
I
T
H
K
---
L
G
-
L
H
A
L
F
W
M
I
A
I
L
A
T
T
G
I
A
L
T
I
W
V
V
P
--
N
S
S
T
H
V
L
N
R
E
S
G
--------
M
V
K
G
S
F
S
K
V
L
A
E
P
R
L
L
K
L
N
F
G
I
M
C
L
H
M
L
L
M
S
------
T
F
V
A
L
P
G
Q
L
A
D
A
G
F
P
A
A
E
H
W
K
V
Y
L
A
T
M
L
I
A
F
G
S
V
V
P
F
I
I
Y
20
HHSearch
44.97
11%
-91
- C3 -
2CFQ
-
LACY_ECOLI
A:
[257-396]
---------------------------------------------------------------------------------------------------------------------------------------------
G
T
R
V
F
G
Y
V
T
T
M
G
------------
E
L
L
N
A
S
I
M
F
F
A
P
---
L
I
I
N
R
I
--
G
G
K
N
A
L
L
L
A
---
G
T
I
M
---
S
V
R
I
I
G
S
S
F
A
----
T
--
S
-
A
L
E
V
V
I
L
K
T
L
H
M
F
E
--
V
P
F
----
L
L
V
G
C
F
K
Y
I
T
S
Q
F
E
V
R
F
S
A
T
-
I
Y
L
V
C------
F
C
F
F
K
Q
L
A
M
-
I
F
M
S
V
L
A
G
N
M
Y
E
--------------------------
S
I
G
-
F
Q
G
A
Y
L
V
L
G
---
L
V
A
L
G
F
T
L
I
S
V
F
T
-
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
43.29
12%
-89
- C3 -
1PW4
-
GLPT_ECOLI
A:
[281-431]
---------------------------------------------------------------------------------------------------------------------------------------
K
E
V
K
H
F
A
L
D
K
S
S
W
A
Y
F
L
Y
------------
E
Y
A
G
I
P
G
T
L
L
C
G
---
W
M
S
D
K
V
--
F
R
G
N
R
G
A
T
G
---
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
W
M
N
P
--
A
G
--
N
-
P
T
V
D
M
I
C
M
I
V
I
G
F
L
--
I
Y
G
----
P
V
M
L
I
G
L
H
A
L
E
L
A
P
K
K
A
A
G
T
-
A
A
G
F
-------
T
G
L
F
G
Y
L
G
G
S
V
A
A
S
A
I
V
G
Y
T
V
D
--------------------------
F
F
G
-
W
D
G
G
F
M
V
M
I
---
G
G
S
I
L
A
V
I
L
L
I
V
V
-
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
42.48
13%
-101
- C3 -
2GFP
-
EMRD_ECOLI
A:
[23-174]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
T
I
Y
I
P
A
I
A
D
M
A
R
D
--
L
---
N
V
R
E
G
A
V
Q
---
S
V
M
G
A
Y
L
L
---
T
Y
G
V
S
Q
L
F
Y
G
P
I
S
D
R
V
G
R
R
P
V
I
L
V
----------
G
M
S
I
F
M
L
A
T
L
V
A
V
T
T
--
S
---
S
L
T
V
L
I
A
-
A
-
S
A
M
Q
G
M
G
T
G
V
G
G
V
-
M
A
R
T
L
P
R
D
L
Y
E
R
T
Q
L
R
H
A
N
S
L
L
-
N
M
G
-
I
L
V
S
P
L
-
L
A
P
L
---
I
G
G
L
L
D
T
M
---
W
N
-
W
R
A
C
Y
L
F
L
L
V
L
C
A
G
V
T
F
S
M
A
R
W
M
P
--
E
T
R
P
V
D
A
P
R
T
R
L
--------
L
T
S
Y
K
T
L
F
G
N
S
G
F
N
C
Y
L
L
M
L
I
G
G
L
A
G
I
A
A
F
E
------
A
C
S
G
V
L
M
G
A
V
L
G
L
S
S
M
T
V
S
I
L
F
I
L
P
I
P
A
A
F
F
G
A
W
F
A
G
R
P
N
23
HHSearch
42.13
12%
-119
- C3 -
3O7Q
1
FUCP_ECOLI
A:
[36-177]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
W
A
V
A
N
N
L
N
D
I
L
L
P
Q
F
Q
Q
A
--
F
---
T
L
T
N
F
Q
A
G
---
L
I
Q
S
A
F
Y
F
---
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
K
L
S
Y
K
A
G
I
----------
I
T
G
L
F
L
Y
A
L
G
A
A
L
F
W
P
A
--
A
E
I
M
N
Y
T
L
F
L
V
-
G
L
F
I
I
A
A
G
L
-
G
C
L
E
T
A
A
-
N
P
F
V
T
V
L
G
P
E
S
S
G
H
F
R
L
N
L
A
-
Q
T
F
-
N
S
F
G
A
I
-
I
A
V
V
---
F
G
Q
S
L
I
L
S
N
V
P
H
Q
-
S
Q
D
V
L
D
K
M
S
P
E
Q
L
S
A
Y
K
H
S
L
V
L
S
V
--
Q
T
P
Y
M
I
I
V
A
I
V
L
--------
L
V
A
L
L
I
M
L
T
K
F
P
A
L
Q
S
D
N
H
S
D
A
K
Q
G
S
F
S
A
S
L
------
S
R
L
A
R
I
R
H
W
R
W
A
V
L
A
Q
F
C
Y
V
G
A
Q
T
A
C
W
S
Y
L
I
R
Y
A
V
E
E
I
P
G
1
PsiBlast_PDB
36.35
32%
54
- C2 -
3J04
-
MLRM_CHICK
B:
[56-124]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
A
S
M
G
K
N
P
T
D
E
------
Y
L
E
G
M
M
S
E
A
P
G
P
I
N
F
T
M
F
L
T
M
F
G
E
K
L
N
G
T
D
P
E
D
V
I
R
N
A
F
A
C
F
D
E
E
A
S
G
F
I
H
E
D
H
L
R
E
L
L
T
T
M
G
D
R
F
T
D
E
E
V
D
E
------
M
Y
R
E
A
P
I
D
K
K
G
N
F
N
Y
V
E
F
T
R
I
L
K
H
G
A
K
-------------
11
Fugue
33.77
30%
64
- C2 -
2AXT
-
PSBT_THEEB
T:
[1-30]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
T
-
I
T
Y
V
F
I
F
A
C
I
I
A
---
L
F
F
F
A
I
F
F
R
--
E
P
P
R
I
T
G
L
P
W
Y
R
--------
V
H
T
V
L
I
N
D
P
G
R
L
I
A
A
H
L
M
H
T
A
L
V
A
G
W
A
G
S
M
A
------
L
Y
E
L
A
T
F
D
P
S
D
P
V
L
N
P
M
W
R
Q
G
M
F
V
L
P
F
M
A
R
L
G
V
T
G
S
W
S
G
W
7
Fugue
31.15
23%
341
- C2 -
4MQV
-
SMAL1_HUMAN
B:
[1-26]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
E
E
Q
R
K
K
I
E
E
N
R
Q
K
A
L
A
R
R
A
E
K
L
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
Fugue
30.50
30%
88
- C2 -
4PBU
-
PSBT_THEEB
T:
[1-30]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
T
-
I
T
Y
V
F
I
F
A
C
I
I
---
A
L
F
F
F
A
I
F
F
R
--
E
P
P
R
I
T
A
N
L
W
E
R
--------
F
C
N
W
V
T
S
T
D
N
R
L
Y
V
G
W
F
G
V
I
M
I
P
T
L
L
A
A
T
I
C
------
F
V
I
A
F
I
A
A
P
P
V
D
I
D
G
I
R
E
P
V
S
G
S
L
L
Y
G
N
N
I
I
T
G
A
V
V
P
S
S
N
13
Fugue
28.21
30%
124
- C2 -
3A0B
-
PSBT_THEVL
T:
[1-30]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
T
-
I
T
Y
V
F
I
F
A
C
I
I
---
A
L
F
F
F
A
I
F
F
R
--
E
P
P
R
I
T
-------------------------------------------------------------------------------------------
8
Fugue
25.54
21%
223
- C2 -
2KV5
-
?
A:
[1-33]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
D
L
---
M
S
L
V
I
A
P
I
F
V
G
L
V
L
E
M
I
S
R
V
L
D
E
E
D
D
S
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------