@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : YLAT2_HUMAN: (2015-12-12 )
MEAREPGRPTPTYHLVPNTSQSQVEEDVSSPPQRSSETMQLKKEISLLNGVSLVVGNMIGSGIFVSPKGVLVHTASYGMSLIVWAIGGLFSVVGALCYAELGTTITKSGASYAYILEAFGGFIAFIRLWVSLLVVEPTGQAIIAITFANYIIQPSFPSCDPPYLACRLLAAACICLLTFVNCAYVKWGTRVQDTFTYAKVVALIAIIVMGLVKLCQGHSEHFQDAFEGSSWDMGNLSLALYSALFSYSGWDTLNFVTEEIKNPERNLPLAIGISMPIVTLIYILTNVAYYTVLNISDVLSSDAVAVTFADQTFGMFSWTIPIAVALSCFGGLNASIFASSRLFFVGSREGHLPDLLSMIHIERFTPIPALLFNCTMALIYLIVEDVFQLINYFSFSYWFFVGLSVVGQLYLRWKEPKRPRPLKLSVFFPIVFCICSVFLVIVPLFTDTINSLIGIGIALSGVPFYFMGVYLPESRRPLFIRNVLAAITRGTQQLCFCVLTELDVAEEKKDERKTD
Atome Classification :
(20 SA)
......-...10........20........30........40.-.......50........60........70........80.......--.90.....----...100.....-...110.......120-..--.-..----....130..----.....140.......150.......160.--......170.....---..180.....---..190.......200.......210--......-..----220.---...---.-...---230-....---...240....--....250.......260.......270.......280.......290---......---------------...--300........---310------.-.-....-.320.......330---.......340.......350.......360--.........370.......380---.-------......390....-...400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510...-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEAREP-GRPT
P
T
Y
H
LVPNT
S
Q
S
Q
V
E
E
D
VSSPPQR
S
S
E
T
M
Q
L
K
-
K
E
I
S
L
LN
G
V
S
L
V
V
G
N
MIGS
G
I
F
VSPK
G
V
L
V
H
TASY
G
M
S
L
I
V
W
A
I
G
G
--
L
F
S
V
V
G
A
L
----
C
Y
A
E
L-GTTIT-KSGA
S
Y
A
Y
I
L
E
AF
G
---
G
F
--
I
-
A
F
----
I
R
L
W
V
S
L
L
V
----VEPTG
Q
A
I
I
A
I
T
FAN
Y
I
IQPSFPSCD
P
P
Y
--
L
A
C
R
L
L
A
A
A
C
I
C
L
L
---
T
F
V
N
C
A
Y
V
KW---GTR
V
Q
D
T
F
T
Y
A
K
V
V
A
L
I
A
I
I
V
M
G
L
---
V
K
L
CQG-
H
S
----
E
H
-
F
---
Q
D
A
---F-EGS---SWD-M
G
N
L
---
S
L
A
L
-
Y
S
A
L
F
--SYSGW
D
T
L
N
F
V
T
E
E
IKNPERNL
P
L
A
IGIS
M
P
I
V
T
L
I
Y
I
L
T
N
V
A
Y
Y
-----
T
V
L
N
I
S
---------------
D
VL--S-SD
A
V
A
V
T
FA---DQ
T
------
F
-
G
-
M
F
S
W-
T
I
P
I
A
V
A
L
S
C
FGGL---N
A
S
I
F
AS
S
R
L
F
F
V
GSREGH
L
P
D
L
L
S
M
I
H
----
I
ERFTP
I
P
A
L
L
F
N
C
T
M
A
L
I
Y
L
I
---
V
-------
E
D
V
F
Q
L
I
N
Y
F
S
F
S
-
Y
W
F
F
V
G
L
S
V
V
G
Q
L
Y
L
R
WKEPKRPR
P
L
K
L
S
V
F
F
P
I
V
F
C
I
C
S
V
F
L
V
I
V
P
L
F
T
D
T
I
N
S
L
I
G
I
G
I
ALSGV
P
F
Y
F
M
G
V
YLPESRR
P
L
F
I
R
N
V
L
A
A
I
T
R
G
T
Q
Q
L
C
F
C
V
L
TELDV
A
E
E
K
K
DERKTD-
19
Fugue
95.02
19%
-127
- C3 -
3GIA
7
Y609_METJA
A:
[3-435]
----------------------------------------
L
K
N
-
K
K
L
S
L
W
E
A
V
S
M
A
V
G
V
M
I
G
A
S
I
F
S
-
I
F
G
V
G
A
K
I
A
G
R
N
L
-
P
E
T
F
I
L
S
G
--
I
Y
A
L
L
V
A
Y
----
S
Y
T
K
L
-
G
A
K
I
V
-
S
N
A
G
P
I
A
F
I
H
K
A
I
G
---
D
N
--
I
-
I
T
----
G
A
L
S
I
L
L
W
M
----
S
Y
V
I
S
I
A
L
F
A
K
G
F
A
G
Y
F
L
P
L
--
I
N
A
P
I
N
T
--
F
N
I
A
I
T
E
I
G
I
V
A
F
F
---
T
A
L
N
F
F
G
S
K
A
---
V
G
R
A
E
F
F
I
V
L
V
K
L
L
I
L
G
L
F
I
F
A
G
L
---
I
T
I
H
P
S
-
Y
V
----
I
P
-
D
---
L
---------
A
---
P
S
A
-
V
S
G
M
---
I
F
A
S
-
A
I
F
F
L
--
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
F
I
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
S
A
I
-----
G
N
L
P
I
D
---------------
E
L
I
K
A
S
-
E
N
A
L
A
V
A
A
K
---
P
F
L
------
G
-
N
-
L
G
F
L
-
L
I
S
I
G
A
L
F
S
I
S
S
A
M
---
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
E
F
F
E
R
K
V
----
W
F
K
S
T
E
G
L
Y
I
T
S
A
L
G
V
L
F
A
L
L
F
------------
N
M
E
G
V
A
S
I
T
S
A
V
-
F
M
V
I
Y
L
F
V
I
L
S
H
Y
I
L
I
D
E
V
G
G
R
K
E
I
V
I
F
S
F
I
V
V
L
G
V
F
L
L
L
L
Y
Y
Q
W
I
T
N
---------------------------------
R
F
V
F
Y
G
I
I
A
T
F
I
G
V
L
I
F
E
I
I
Y
R
K
V
T
K
R
T
F
S
N
N
M
Y
V
K
S
--
10
HHSearch
93.82
19%
-127
- C3 -
3GIA
7
Y609_METJA
A:
[3-421]
----------------------------------------
L
K
N
-
K
K
L
S
L
W
E
A
V
S
M
A
V
G
V
M
I
G
A
S
I
F
S
I
F
G
V
G
A
K
-
I
A
G
R
-
N
L
P
E
T
F
I
L
S
G
--
I
Y
A
L
L
V
A
Y
----
S
Y
T
K
L
-
G
A
K
I
V
-
S
N
A
G
P
I
A
F
I
H
K
A
I
G
---
D
N
--
I
I
T
G
----
A
L
S
I
L
L
W
M
-----
S
Y
V
I
S
I
A
L
F
A
K
G
F
A
G
Y
F
L
P
-
L
I
N
A
P
-
I
N
T
--
F
N
I
A
I
T
E
I
G
I
V
A
F
F
---
T
A
L
N
F
F
G
S
K
A
---
V
G
R
A
E
F
F
I
V
L
V
K
L
L
I
L
G
L
F
I
F
A
G
L
---
I
T
I
H
----
P
----
S
Y
-
V
---
I
P
D
---
L
-
A
P
S
-----
A
-
V
S
G
M
---
I
F
A
S
-
A
I
F
F
L
--
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
F
I
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
S
A
I
-----
G
N
L
P
I
D
---------------
E
L
I
--
K
A
S
E
N
A
L
A
V
A
A
---
K
P
F
------
L
-
G
N
L
G
F
L
-
L
I
S
I
G
A
L
F
S
I
S
S
A
M
---
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
E
F
F
E
R
K
V
-----
W
F
K
S
T
-
E
G
L
Y
I
T
S
A
L
G
V
L
F
A
L
---
L
-------
F
N
M
E
G
V
A
S
I
T
S
A
V
-
F
M
V
I
Y
L
F
V
I
L
S
H
Y
I
L
I
D
E
V
G
G
R
K
E
-
I
---
V
I
F
S
F
I
V
V
L
G
V
F
L
L
L
L
Y
Y
Q
W
I
T
N
R
F
V
F
Y
G
I
I
A
T
F
I
G
V
L
I
F
E
I
I
Y
R
K
V
T
K
R
T
F
S
N
N
M
Y
V
K
S
-------------------------------
11
HHSearch
89.35
19%
-119
- C3 -
3L1L
2
ADIC_ECO57
A:
[7-386]
------------------------------------------
A
-
H
K
V
G
L
I
P
V
T
L
M
V
S
G
A
I
M
G
S
G
V
F
L
L
P
A
N
L
-
A
S
T
G
G
--
I
A
I
Y
G
W
L
V
T
I
--
I
G
A
L
G
L
S
M
----
V
Y
A
K
M
-
S
F
L
D
P
-
S
P
G
G
S
Y
A
Y
A
R
R
C
F
G
---
P
F
--
L
-
G
Y
----
Q
T
N
V
L
Y
W
L
-----
A
C
W
I
G
N
I
A
M
V
V
I
G
V
G
Y
L
S
-
Y
F
F
P
I
L
K
D
-
P
--
W
V
L
T
I
T
C
V
V
V
L
W
I
F
---
V
L
L
N
I
V
G
P
K
M
---
I
T
R
V
Q
A
V
A
T
V
L
A
L
I
P
I
V
G
I
A
V
F
G
W
---
F
W
F
R
G
--------
E
T
-
Y
---
M
A
------------------
A
I
---
Q
S
T
L
-
N
V
T
L
W
--
S
F
I
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
P
I
A
T
I
G
G
V
L
I
A
A
V
C
Y
V
L
S
T
T
A
I
M
-----
G
M
I
P
N
A
---------------
A
L
R
--
V
-
S
A
S
P
F
G
D
A
A
---
R
M
A
------
L
-
G
D
T
A
G
A
-
I
V
S
F
C
A
A
A
G
C
L
G
S
L
---
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
P
I
F
A
R
V
N
-----
K
A
G
T
P
V
A
G
L
I
I
V
G
I
L
M
T
I
F
Q
L
---
S
SISPNAT
K
E
F
G
L
V
S
S
V
S
V
I
F
-
T
L
V
P
Y
L
Y
T
C
A
A
L
L
L
L
G
H
G
H
F
G
K
A
R
P
A
Y
L
A
V
T
T
I
A
F
L
Y
C
I
W
A
V
V
G
S
G
A
K
E
V
M
W
S
F
V
T
L
M
V
I
T
A
M
Y
A
L
N
Y
N
R
L
H
K
N
P
Y
P
L
D
A
----------------------------------------
5
PsiBlast_PDB
85.41
23%
-122
- C3 -
3LRB
-
ADIC_ECO57
A:
[8-339]
--------------------------------------------
H
K
V
G
L
I
P
V
T
L
M
V
S
G
N
I
M
G
S
G
V
F
L
L
P
A
N
L
---
A
S
T
G
G
I
A
I
Y
G
W
------
L
V
T
I
I
G
A
L
G
L
S
M
V
Y
A
K
M
-
S
F
L
D
P
-
S
P
G
G
S
Y
A
Y
A
R
R
C
F
G
---
P
F
--
L
-
G
Y
Q
T
N
-
V
L
Y
W
L
A
C
W
I
----
G
N
-
I
A
M
V
V
I
G
V
G
Y
L
S
Y
F
----
F
P
I
L
K
D
P
L
--
V
----
L
T
I
T
C
V
V
V
L
W
I
F
V
L
L
N
I
V
G
P
K
M
---
I
T
R
V
Q
A
V
---
A
T
V
L
A
L
I
P
I
V
G
I
A
V
---
F
G
W
F
W
F
-
R
G
----
E
T
-
Y
---
M
A
A
---
W
-
N
V
S
---
G
L
G
T
F
G
A
I
---
Q
S
T
L
-
N
V
T
L
W
--
S
F
I
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
P
I
A
T
I
G
G
V
L
I
A
A
V
C
Y
V
L
S
T
T
A
I
M
GMIPN-----------------------------------------
T
A
------
G
-
A
-
I
V
S
F
-----
C
A
A
A
G
C
L
G
S
L
---
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
P
I
F
A
R
V
N
-----
K
A
G
T
P
V
A
G
L
-------
I
I
V
G
I
---
L
-------
M
T
I
F
Q
L
S
S
I
S
P
N
A
-
T
K
E
F
G
L
V
S
S
V
S
V
I
F
T
L
V
P
Y
L
Y
T
C
A
A
L
L
L
L
G
H
G
H
F
G
K
A
R
P
A
Y
L
A
V
T
T
I
A
F
L
Y
C
I
W
A
V
V
G
S
G
A
K
E
V
M
W
S
F
V
T
L
M
V
I
T
A
M
Y
A
L
N
Y
N
R
L
H
K
N
P
-------------------------------
7
PsiBlast_PDB
85.11
23%
-125
- C3 -
3L1L
2
ADIC_ECO57
A:
[8-339]
--------------------------------------------
H
K
V
G
L
I
P
V
T
L
M
V
S
G
A
I
M
G
S
G
V
F
L
L
P
A
N
L
---
A
S
T
G
G
I
A
I
Y
G
W
------
L
V
T
I
I
G
A
L
G
L
S
M
V
Y
A
K
M
-
S
F
L
D
P
-
S
P
G
G
S
Y
A
Y
A
R
R
C
F
G
---
P
F
--
L
-
G
Y
Q
T
N
-
V
L
Y
W
L
A
C
W
I
----
G
N
-
I
A
M
V
V
I
G
V
G
Y
L
S
Y
F
----
F
P
I
L
K
D
P
W
--
V
----
L
T
I
T
C
V
V
V
L
W
I
F
V
L
L
N
I
V
G
P
K
M
---
I
T
R
V
Q
A
V
---
A
T
V
L
A
L
I
P
I
V
G
I
A
V
---
F
G
W
F
W
F
-
R
G
----
E
T
-
Y
---
M
A
------------------
A
I
---
Q
S
T
L
-
N
V
T
L
W
--
S
F
I
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
P
I
A
T
I
G
G
V
L
I
A
A
V
C
Y
V
L
S
T
T
A
I
M
G
M
IPN
A
A
L
R
V
S
---------------
A
S
P
--
F
-
G
D
A
A
R
M
A
L
G
---
D
T
A
------
G
-
A
-
I
V
S
F
-----
C
A
A
A
G
C
L
G
S
L
---
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
P
I
F
A
R
V
N
-----
K
A
G
T
P
V
A
G
L
-------
I
I
V
G
I
---
L
-------
M
T
I
F
Q
L
S
S
I
S
P
N
A
-
T
K
E
F
G
L
V
S
S
V
S
V
I
F
T
L
V
P
Y
L
Y
T
C
A
A
L
L
L
L
G
H
G
H
F
G
K
A
R
P
A
Y
L
A
V
T
T
I
A
F
L
Y
C
I
W
A
V
V
G
S
G
A
K
E
V
M
W
S
F
V
T
L
M
V
I
T
A
M
Y
A
L
N
Y
N
R
L
H
K
N
P
Y
P
L
D
A
--------------------------
6
PsiBlast_PDB
84.89
23%
-126
- C3 -
3LRC
-
ADIC_ECO57
A:
[8-339]
--------------------------------------------
H
K
V
G
L
I
P
V
T
L
M
V
S
G
N
I
M
G
S
G
V
F
L
L
P
A
N
L
---
A
S
T
G
G
I
A
I
Y
G
W
------
L
V
T
I
I
G
A
L
G
L
S
M
V
Y
A
K
M
-
S
F
L
D
P
-
S
P
G
G
S
Y
A
Y
A
R
R
C
F
G
---
P
F
--
L
-
G
Y
Q
T
N
-
V
L
Y
W
L
A
C
W
I
----
G
N
-
I
A
M
V
V
I
G
V
G
Y
L
S
Y
F
----
F
P
I
L
K
D
P
L
--
V
----
L
T
I
T
C
V
V
V
L
W
I
F
V
L
L
N
I
V
G
P
K
M
---
I
T
R
V
Q
A
V
---
A
T
V
L
A
L
I
P
I
V
G
I
A
V
---
F
G
W
F
W
F
-
R
G
----
E
T
-
Y
---
M
A
A
---
W
-
N
V
S
---
G
L
G
T
F
G
A
I
---
Q
S
T
L
-
N
V
T
L
W
--
S
F
I
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
P
I
A
T
I
G
G
V
L
I
A
A
V
C
Y
V
L
S
T
T
A
I
M
GMIPN-----------------------------------------
T
A
------
G
-
A
-
I
V
S
F
-----
C
A
A
A
G
C
L
G
S
L
---
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
P
I
F
A
R
V
N
-----
K
A
G
T
P
V
A
G
L
-------
I
I
V
G
I
---
L
-------
M
T
I
F
Q
L
S
S
I
S
P
N
A
-
T
K
E
F
G
L
V
S
S
V
S
V
I
F
T
L
V
P
Y
L
Y
T
C
A
A
L
L
L
L
G
H
G
H
F
G
K
A
R
P
A
Y
L
A
V
T
T
I
A
F
L
Y
C
I
W
A
V
V
G
S
G
A
K
E
V
M
W
S
F
V
T
L
M
V
I
T
A
M
Y
A
L
N
Y
N
R
L
H
K
N
P
-------------------------------
4
PsiBlast_PDB
84.34
23%
-116
- C3 -
3OB6
1
ADIC_ECOLI
A:
[8-339]
--------------------------------------------
H
K
V
G
L
I
P
V
T
L
M
V
S
G
N
I
M
G
S
G
V
F
L
L
P
A
N
L
---
A
S
T
G
G
I
A
I
Y
G
W
------
L
V
T
I
I
G
A
L
G
L
S
M
V
Y
A
K
M
-
S
F
L
D
P
-
S
P
G
G
S
Y
A
Y
A
R
R
C
F
G
---
P
F
--
L
-
G
Y
Q
T
N
-
V
L
Y
W
L
A
C
W
I
-----
G
A
I
A
M
V
V
I
G
V
G
Y
L
S
Y
F
----
F
P
I
L
K
D
P
L
--
V
----
L
T
I
T
C
V
V
V
L
W
I
F
V
L
L
N
I
V
G
P
K
M
---
I
T
R
V
Q
A
V
---
A
T
V
L
A
L
I
P
I
V
G
I
A
V
---
F
G
W
F
W
F
-
R
G
----
E
T
-
Y
---
M
A
A
---
W
-
N
V
S
---
G
L
G
T
F
G
A
I
---
Q
S
T
L
-
N
V
T
L
W
--
S
F
I
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
P
I
A
T
I
G
G
V
L
I
A
A
V
C
Y
V
L
S
T
T
A
I
M
G
M
IP
N
A
A
L
R
V
S
---------------
A
S
P
--
F
-
G
D
A
A
R
M
A
L
G
---
D
T
A
------
G
-
A
-
I
V
S
F
-----
C
A
A
A
G
C
L
G
S
L
---
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
P
I
F
A
R
V
N
-----
K
A
G
T
P
V
A
G
L
-------
I
I
V
G
I
---
L
-------
M
T
I
F
Q
L
S
S
I
S
P
G
L
-
V
S
S
V
S
V
I
F
T
L
V
P
Y
L
Y
T
C
A
A
L
L
L
L
G
H
G
H
F
G
K
A
R
P
A
Y
L
A
V
T
T
I
A
F
L
Y
C
I
W
A
V
V
G
S
G
A
K
E
V
M
W
S
F
V
T
L
M
V
I
T
A
M
Y
A
L
N
Y
N
R
L
H
K
N
P
Y
P
L
D
A
--------------------------------
2
PsiBlast_PDB
83.27
26%
-125
- C3 -
3GIA
5
Y609_METJA
A:
[3-310]
-----------------------------------------
L
K
N
K
K
L
S
L
W
E
A
V
S
M
A
V
G
V
M
I
G
A
S
I
F
-
S
I
F
G
V
G
A
K
I
A
G
R
N
L
P
E
-
T
F
I
L
S
G
--
I
Y
A
L
L
V
A
Y
----
S
Y
T
K
L
-
G
A
K
I
V
-
S
N
A
G
P
I
A
F
I
H
K
A
I
G
---
D
N
--
I
-
I
T
G
A
L
S
I
L
L
W
M
S
Y
V
I
--------
S
I
A
L
F
A
K
G
F
A
G
Y
F
L
----
P
L
I
N
A
P
I
N
T
F
N
I
A
I
T
E
I
G
I
V
A
F
F
---
T
A
L
N
F
F
G
S
K
A
---
V
G
R
A
E
F
F
I
V
L
V
K
L
L
I
L
G
L
F
I
F
A
G
L
---
I
T
I
----
H
P
----
S
Y
-
V
---
I
P
D
---
L
-
A
P
S
---
A
V
S
--------
G
M
I
F
-
A
S
A
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
F
I
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
S
A
I
-----
G
N
L
P
I
D
---------------
E
L
I
--
K
-
A
S
E
N
A
L
A
V
A
---
A
K
P
------
F
L
G
-
N
L
G
F
L
L
I
S
I
G
A
L
F
S
I
S
S
A
M
---
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
E
F
F
E
R
K
V
----
W
F
K
S
T
E
G
L
Y
I
T
S
A
L
G
V
L
F
A
L
L
F
---
N
-------
M
E
G
V
A
S
I
T
S
A
V
F
M
-
V
I
Y
L
F
V
I
L
S
H
Y
I
L
I
D
E
V
G
G
R
K
E
I
V
I
F
S
F
I
V
V
L
G
V
F
L
L
L
L
Y
Y
Q
W
I
T
N
R
F
V
F
Y
G
I
I
A
T
F
I
G
V
L
I
F
E
I
I
Y
R
K
V
T
K
R
T
F
S
N
N
M
Y
V
K
S
-------------------------------------
1
PsiBlast_PDB
82.28
26%
-122
- C3 -
3GI9
-
Y609_METJA
C:
[1-310]
---------------------------------------
M
E
L
K
N
K
K
L
S
L
W
E
A
V
S
M
A
V
G
V
M
I
G
A
S
I
F
-
S
I
F
G
V
G
A
K
I
A
G
R
N
L
P
E
-
T
F
I
L
S
G
--
I
Y
A
L
L
V
A
Y
----
S
Y
T
K
L
-
G
A
K
I
V
-
S
N
A
G
P
I
A
F
I
H
K
A
I
G
---
D
N
--
I
-
I
T
G
A
L
S
I
L
L
W
M
S
Y
V
I
--------
S
I
A
L
F
A
K
G
F
A
G
Y
F
L
----
P
L
I
-
A
P
I
N
T
F
N
I
A
I
T
E
I
G
I
V
A
F
F
---
T
A
L
N
F
F
G
S
K
A
---
V
G
R
A
E
F
F
I
V
L
V
K
L
L
I
L
G
L
F
I
F
A
G
L
---
I
T
I
----
H
P
----
S
Y
-
V
---
I
P
D
---
L
-
A
P
S
---
A
V
S
--------
G
M
I
F
-
A
S
A
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
F
I
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
S
A
I
-----
G
N
L
P
I
D
---------------
E
L
I
--
K
-
A
S
E
N
A
L
A
V
A
---
A
K
P
------
F
L
G
-
N
L
G
F
L
L
I
S
I
G
A
L
F
S
I
S
S
A
M
---
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
E
F
F
E
R
K
V
----
W
F
K
S
T
E
G
L
Y
I
T
S
A
L
G
V
L
F
A
L
L
F
---
N
-------
M
E
G
V
A
S
I
T
S
A
V
F
M
-
V
I
Y
L
F
V
I
L
S
H
Y
I
L
I
D
E
V
G
G
R
K
E
I
V
I
F
S
F
I
V
V
L
G
V
F
L
L
L
L
Y
Y
Q
W
I
T
N
R
F
V
F
Y
G
I
I
A
T
F
I
G
V
L
I
F
E
I
I
Y
R
K
V
T
K
R
T
F
S
N
N
M
Y
V
K
S
L
E
S
----------------------------------
3
PsiBlast_PDB
80.53
26%
-129
- C3 -
3GI8
-
Y609_METJA
C:
[1-310]
---------------------------------------
M
E
L
K
N
K
K
L
S
L
W
E
A
V
S
M
A
V
G
V
M
I
G
A
S
I
F
-
S
I
F
G
V
G
A
K
I
A
G
R
N
L
P
E
-
T
F
I
L
S
G
--
I
Y
A
L
L
V
A
Y
----
S
Y
T
K
L
-
G
A
K
I
V
-
S
N
A
G
P
I
A
F
I
H
K
A
I
G
---
D
N
--
I
-
I
T
GALS
I
L
L
W
M
S
Y
V
I
--------
S
I
A
L
F
A
K
G
F
A
G
Y
F
L
----
P
L
I
N
A
P
---
I
N
T
F
N
I
A
I
T
E
I
G
I
V
---
A
F
F
-
T
A
L
N
F
F
---
G
S
K
A
V
G
R
A
E
F
--
F
I
V
L
V
A
L
L
I
L
G
L
FIF
A
G
L
I
T
I
-
H
P
----
S
Y
-
V
---
I
P
D
---
L
-
A
P
S
---
A
V
S
--------
G
M
I
F
-
A
S
A
I
F
FL
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
F
I
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
S
A
I
-----
G
N
L
P
I
D
---------------
E
L
I
--
K
-
A
S
E
N
A
L
A
V
A
---
A
K
P
------
F
L
G
-
N
L
G
F
L
L
I
S
I
G
A
L
F
S
I
S
S
A
M
---
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
E
F
F
E
R
K
V
----
W
F
K
S
T
E
G
L
Y
I
T
S
A
L
G
V
L
F
A
L
L
F
---
N
-------
M
E
G
V
A
S
I
T
S
A
V
F
M
-
V
I
Y
L
F
V
I
L
S
H
Y
I
L
I
D
E
V
G
G
R
K
E
I
V
I
F
S
F
I
V
V
L
G
V
F
L
L
L
L
Y
Y
Q
W
I
T
N
R
F
V
F
Y
G
I
I
A
T
F
I
G
V
L
I
F
E
I
I
Y
R
K
V
T
K
R
T
F
S
N
N
M
Y
V
K
S
-------------------------------------
21
Fugue
79.09
14%
-111
- C3 -
4DJK
-
GADC_ECOLI
A:
[12-501]
---------------------------------
Q
L
T
L
L
G
F
F
A
I
-
T
A
S
M
V
M
A
V
Y
E
Y
P
T
F
A
T
S
G
----------------
F
S
L
V
F
F
L
L
L
G
G
I
--
L
W
F
I
P
V
G
L
----
C
A
A
E
M
-
A
T
V
---
D
G
W
G
V
F
A
W
V
S
N
T
L
G
P
R
W
G
F
--
A
-
A
I
----
S
F
G
Y
L
Q
I
A
I
----
G
F
I
P
M
L
Y
F
V
L
G
A
L
S
Y
I
L
K
W
P
A
L
N
E
D
---------
P
I
T
K
T
I
A
A
L
I
I
---
L
W
A
L
A
L
T
Q
F
G
---
G
T
K
Y
T
A
R
I
A
K
V
G
F
F
A
G
I
L
L
P
A
F
I
L
---
I
A
L
A
A
I
-
Y
L
----
H
T
-
F
---
F
P
D
---
F
-
S
K
V
---------
G
T
---
L
V
V
F
-
V
A
F
I
L
--
S
Y
M
G
V
E
A
S
A
T
H
V
N
E
M
S
N
P
G
R
D
Y
P
L
A
M
L
L
L
M
V
A
A
I
C
L
S
S
V
G
G
L
S
I
A
-----
M
V
I
P
G
N
---------------
E
I
N
--
L
-
S
A
G
V
M
Q
T
F
T
---
V
L
M
SHVAPE
I
-
E
-
W
T
V
R
-
V
I
S
A
L
L
L
L
G
V
L
A
E
I
---
A
S
W
I
V
G
P
S
R
G
M
Y
V
T
A
Q
K
N
L
L
P
A
A
F
A
K
M
N
KN
G
V
P
V
T
L
V
I
S
Q
L
V
I
T
S
I
A
L
I
I
L
T
N
T
GGG
N
-------
N
M
S
F
L
I
A
L
A
L
T
V
V
I
Y
L
C
A
Y
F
M
L
F
I
G
Y
I
V
L
V
L
K
H
P
D
L
K
R
T
F
N
I
P
--------------------
G
G
K
G
V
K
L
V
V
A
I
V
G
L
L
T
S
I
M
A
F
I
V
S
F
L
P
P
D
N
I
Q
G
D
S
T
D
M
Y
V
E
L
L
V
V
S
F
L
V
V
L
A
L
P
F
I
L
Y
A
V
H
F
F
L
H
P
R
A
R
S
P
24
Fugue
75.73
17%
-113
- C3 -
4LL8
-
A:
[99-536]
-------
E
R
A
A
A
Q
S
S
L
I
Q
S
H
M
Q
S
L
A
A
N
K
---
P
S
R
L
S
D
E
V
K
S
M
K
-
Q
E
L
A
F
I
E
N
V
I
A
Q
A
N
K
---------
P
K
L
V
N
V
I
R
R
E
S
G
N
P
D
L
L
E
L
L
M
D
--
L
N
S
Y
T
L
E
V
----
T
E
G
Y
L
K
K
V
N
V
T
-
E
V
N
G
D
N
V
L
---------
G
P
--
I
-
H
V
----
I
T
T
V
V
S
S
L
V
R
N
GL
L
I
Q
S
S
K
F
I
S
K
V
L
L
T
V
E
S
I
V
M
S
L
P
K
-
D
E
T
M
--
L
G
G
I
F
W
L
S
N
L
S
R
L
P
---
A
F
A
A
N
Q
K
T
L
Y
EAN
G
G
D
E
K
D
K
L
T
L
I
Y
L
N
D
L
E
N
E
T
L
K
V
F
---
D
K
I
Y
----
S
----
T
W
-
L
---
V
K
F
---
M
-
K
H
A
---
S
A
H
-
I
E
I
F
---
D
M
V
L
-
N
E
K
L
F
--
K
N
S
G
D
E
K
F
A
K
L
F
T
F
L
N
E
F
D
A
V
L
S
K
----------------------------
F
Q
V
V
---------------
D
S
M
--
H
-
T
K
I
F
N
D
T
L
K
---
Y
L
N
------
V
-
M
-
L
F
N
D
-
L
I
T
K
S
P
A
L
N
-----------------
W
K
Y
G
Y
E
V
D
R
N
I
E
R
L
V
S
W
F
E
-----
P
R
I
E
D
V
R
P
N
L
I
Q
I
I
Q
A
V
K
I
L
Q
---
L
-------
K
I
S
N
L
N
E
F
K
L
L
F
D
-
F
W
Y
A
L
N
P
A
Q
I
Q
A
I
L
L
K
Y
K
P
A
N
K
G
E
A
G
-----------------
V
P
N
E
I
L
N
Y
L
A
N
V
I
K
R
E
N
L
S
L
P
G
K
M
E
I
M
L
S
A
Q
F
D
S
A
K
N
H
L
--
R
Y
D
T
S
A
I
T
Q
N
S
N
-------
T
E
G
L
A
T
V
S
K
I
I
K
L
----
9
PsiBlast_PDB
74.72
21%
-141
- C3 -
4DJK
-
GADC_ECOLI
A:
[36-355]
----------------------------------------------------------------------------
A
T
S
G
F
S
L
V
F
F
L
L
L
G
G
I
L
W
F
I
P
V
G
L
----
C
A
A
E
M
-
A
T
V
D
G
W---
G
V
F
A
W
V
S
N
T
L
G
P
R
W
G
F
A
A
I
-
S
F
----
G
Y
L
Q
I
A
I
G
F
----
I
P
M
L
Y
F
V
L
G
A
L
S
---
Y
I
L
K
--
W
P
A
L
N
E
D
P
--
I
T
K
T
I
A
A
L
I
I
L
W
A
L
---
A
L
T
Q
F
G
G
T
K
Y
---
T
A
R
I
A
K
V
G
F
F
A
G
I
L
-
L
P
A
F
I
L
I
A
L
---
A
A
I
Y
L
--
H
--------------
T
---
F
-
F
P
D
---
F
S
K
-
V
G
T
L
----
V
V
F
-
V
A
F
I
L
--
S
Y
M
G
V
E
A
S
A
T
H
V
N
E
M
S
N
P
G
R
D
Y
P
L
A
M
L
L
L
M
V
A
A
I
C
L
S
S
V
G
G
L
S
I
A
-----
M
V
I
P
G
N
---------------
E
I
N
--
L
-
S
A
G
V
M
Q
T
F
T
V
L
M
S
H
V
------
A
-
P
-
E
I
E
W
-
T
V
R
V
I
S
A
L
L
L
L
G
V
L
A
E
I
A
S
W
I
V
G
P
S
R
G
M
Y
V
T
A
Q
K
N
L
L
P
A
A
F
A
K
M
N
-----
K
N
G
V
P
V
T
L
V
I
S
Q
L
V
I
T
S
I
A
L
I
---
I
-------
L
T
N
T
G
G
G
N
N
M
S
F
L
-
I
A
L
A
L
T
V
V
I
Y
L
C
A
Y
F
M
L
F
I
G
Y
I
V
L
V
L
K
H
P
D
L
K
R
T
F
N
I
P
G
G
K
G
V
K
L
V
V
A
I
V
G
L
L
T
S
I
M
A
F
I
V
S
F
L
P
P
D
N
I
Q
G
D
S
T
D
M
Y
V
E
L
L
V
V
S
F
L
V
V
L
A
L
P
F
I
L
Y
A
V
H
F
F
L
H
P
R
A
R
S
P
-----------
8
PsiBlast_PDB
73.07
21%
-138
- C3 -
4DJI
-
GADC_ECOLI
A:
[36-355]
----------------------------------------------------------------------------
A
T
S
G
F
S
L
V
F
F
L
L
L
G
G
I
L
W
F
I
P
V
G
L
----
C
A
A
E
M
-
A
T
V
D
G
W
E
E
G
G
V
F
A
W
V
S
N
T
L
G
P
R
W
G
F
A
A
I
-
S
F
----
G
Y
L
Q
I
A
I
G
F
----
I
P
M
L
Y
F
V
L
G
A
L
S
---
Y
I
L
K
--
W
P
A
L
N
E
D
P
--
I
T
K
T
I
A
A
L
I
I
L
W
A
L
---
A
L
T
Q
F
G
G
T
K
Y
---
T
A
R
I
A
K
V
G
F
F
A
G
I
L
-
L
P
A
F
I
L
I
A
L
---
A
A
I
Y
L
--
H
S
GAI-
E
M
-
D
---
S
K
T
---
F
-
F
P
D
---
F
S
K
-
V
G
T
L
----
V
V
F
-
V
A
F
I
L
--
S
Y
M
G
V
E
A
S
A
T
H
V
N
E
M
S
N
P
G
R
D
Y
P
L
A
M
L
L
L
M
V
A
A
I
C
L
S
S
V
G
G
L
S
I
A
-----
M
V
I
P
G
N
---------------
E
I
N
--
L
-
S
A
G
V
M
Q
T
F
T
V
L
M
S
H
V
------
A
-
P
-
E
I
E
W
-
T
V
R
V
I
S
A
L
L
L
L
G
V
L
A
E
I
A
S
W
I
V
G
P
S
R
G
M
Y
V
T
A
Q
K
N
L
L
P
A
A
F
A
K
M
N
-----
K
N
G
V
P
V
T
L
V
I
S
Q
L
V
I
T
S
I
A
L
I
---
I
-------
L
T
N
T
G
G
G
N
N
M
S
F
L
-
I
A
L
A
L
T
V
V
I
Y
L
C
A
Y
F
M
L
F
I
G
Y
I
V
L
V
L
K
H
P
D
L
K
R
T
F
N
I
P
G
G
K
G
V
K
L
V
V
A
I
V
G
L
L
T
S
I
M
A
F
I
V
S
F
L
P
P
D
N
I
Q
G
D
S
T
D
M
Y
V
E
L
L
V
V
S
F
L
V
V
L
A
L
P
F
I
L
Y
A
V
H
D
A
N
T
G
V
T
L
E
P
I
N
S
Q
N
A
P
K
G
H
-
13
HHSearch
43.62
8%
-72
- C3 -
3DH4
1
?
A:
[53-355]
------------------------------------------
G
-
K
S
L
P
W
W
A
V
G
A
S
L
I
A
A
N
I
S
A
E
Q
F
I
G
M
S
G
S
G
Y
-
S
I
G
L
A
I
A
-
S
Y
E
W
M
S
A
--
I
T
L
I
I
V
G
K
----
Y
F
L
P
I
-
F
I
E
K
--
G
I
Y
T
I
P
E
F
V
E
K
R
F
N
---
K
K
--
L
-
K
T
----
I
L
A
V
F
W
I
S
L
----
Y
I
F
V
N
L
T
S
V
L
Y
L
G
G
L
A
L
-
E
T
I
L
G
I
---
P
----
L
M
Y
S
I
L
G
L
A
L
F
A
L
---
V
Y
S
I
---------
V
V
W
T
D
V
I
Q
V
F
F
L
V
L
G
G
F
M
T
T
Y
M
A
V
---
S
F
I
G
G
T
D
G
W
F
A
G
V
S
K
M
V
D
A
A
P
G
H
FEM
I
L
D
Q
S
NPQ
Y
M
N
-
L
P
G
I
AVL
I
G
G
L
W
V
A
N
L
Y
--
Y
W
G
F
N
Q
Y
I
I
Q
R
T
L
A
A
K
S
V
-
S
E
A
Q
K
G
I
V
F
A
A
F
L
K
L
I
V
P
F
L
V
V
L
P
G
I
A
A
Y
--
V
I
T
S
D
P
Q
L
M
A
S
L
GDIAATNLP
S
A
A
--
N
-
A
D
K
A
Y
P
W
L
T
----
Q
F
------
L
-
P
V
G
V
K
G
-
V
V
F
A
A
L
A
A
A
I
V
S
S
L
---
A
S
M
L
N
S
T
A
T
I
F
T
---
M
D
I
Y
K
E
Y
I
S
P
D
S
G
----
D
H
K
L
V
N
V
G
R
T
A
A
V
V
A
L
I
I
A
C
L
I
---
A
-------
P
M
L
G
G
I
G
Q
A
F
Q
Y
I
-
Q
E
Y
T
G
L
V
S
P
G
I
L
A
V
F
L
L
G
L
F
W
K
K
T
T
S
K
G
A
I
I
G
V
V
A
S
I
P
F
A
L
F
L
K
F
M
P
L
S
M
P
F
M
D
Q
M
L
Y
T
L
L
F
T
M
V
V
I
A
F
T
S
L
S
T
S
I
N
D
D
D
P
K
G
I
S
V
T
S
S
M
F
V
T
D
R
S
F
N
I
A
A
Y
G
I
M
I
V
L
A
V
L
Y
T
L
F
W
V
L
Y
-
23
Fugue
42.56
21%
190
- C3 -
2KKE
-
?
A:
[1-53]
M
V
G
R
R
P
G
G
G
L
K
D
T
K
P
V
V
V
R
L
Y
P
D
E
I
E
A
L
K
S
R
V
P
A
N
T
S
M
S
A
Y
I
R
-
R
I
I
L
N
H
L
E
D
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Fugue
38.80
12%
233
- C3 -
2K6I
-
Y223_METJA
A:
[1-47]
-
M
G
V
S
V
-
M
E
A
I
K
E
V
K
L
A
E
E
Q
A
V
K
E
I
E
E
A
K
N
R
A
E
Q
I
K
A
E
A
I
E
E
A
-
K
K
L
I
A
C
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Fugue
38.65
13%
251
- C3 -
1JDH
-
TF7L2_HUMAN
B:
[12-49]
---------
L
G
A
N
D
E
L
I
S
F
K
D
E
G
E
Q
E
E
K
S
S
E
N
S
S
A
E
R
D
L
A
D
V
K
-
S
S
L
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Fugue
37.16
15%
48
- C3 -
1EGW
2
MEF2A_HUMAN
A:
[1-71]
------------
G
R
K
K
I
Q
I
T
R
I
M
D
E
R
N
R
Q
V
T
F
T
K
R
K
F
G
L
M
K
K
A
-
Y
E
L
S
V
L
C
D
C
E
I
-------
A
L
I
I
F
N
S
S
N
K
L
F
Q
Y
A
S
T
D
M
D
K
V
L
L
K
Y
T
E
--
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Fugue
35.68
22%
326
* C3 *
1FMH
3
GCN4_YEAST
A:
[1-31]
-----------------------
E
V
A
Q
L
E
K
E
V
A
Q
A
E
A
E
N
Y
Q
L
E
-
Q
E
V
A
Q
L
E
H
E
C
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------