@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ZNT3_HUMAN: (2015-12-12 )
MEPSPAAGGLETTRLVSPRDRGGAGGSLRLKSLFTEPSEPLPEESKPVEMPFHHCHRDPLPPPGLTPERLHARRQLYAACAVCFVFMAGEVVGGYLAHSLAIMTDAAHLLADVGSMMGSLFSLWLSTRPATRTMTFGWHRSETLGALASVVSLWMVTGILLYLAFVRLLHSDYHIEGGAMLLTASIAVCANLLMAFVLHQAGPPHSHGSRGAEYAPLEEGPEEPLPLGNTSVRAAFVHVLGDLLQSFGVLAASILIYFKPQYKAADPISTFLFSICALGSTAPTLRDVLRILMEGTPRNVGFEPVRDTLLSVPGVRATHELHLWALTLTYHVASAHLAIDSTADPEAVLAEASSRLYSRFGFSSCTLQVEQYQPEMAQCLRCQEPPQA
Atome Classification :
(20 SA)
---------------------------...----......10........--20........30.-------.......40.--.......50...-----.....60........70........80.-------------.......90-----------------------------------....---------....----100.......110....----.....120------.....--....130-.-.......140.........150.......160-------------------...---------------....-------..170--..---.......180---.......190.----......200.......210.......220-......------.230.......240.......250.......260-........270.......280.....-..290.--.....--.300.......310--.......320....-...330.......340-.---.---...-.-..-.350...-----....360........-------370....-----...380......----------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------MEP----SPAAGGL
E
T
T
RLVSPR--DRGGAGG
S
L
R
L
K
S
-------
L
FTEPSEPLP--EESKPVEM
P
F
H
H
-----CHRDPLPPPGL
T
P
E
R
L
H
A
R
R
Q
L
Y
A
A
C
A
V
-------------
C
F
V
F
M
A
G
E
V
-----------------------------------
V
G
G
Y
---------
L
A
H
S
----
L
A
I
M
T
D
A
A
H
L
L
--
A
D
V
G
----
S
M
M
G
S
L
--------
F
S
L
W
L
--STRPAT--
R
-
T
M
T
F
GWHR--
S
E
T
L
G
A
L
A
S
V
V
S
L
W
M
V
T
G
I
L
---------------------
L
Y
L
---------------
A
F
V
R
-------
L
L
H----SD---YHIEG
G
A
M
L
L
---
T
A
S
I
A
V
C
A
N
L
L
----
M
A
F
V
L
HQAGPPHSHGSRGAEYAPLEEGPE-EPLPLG------
N
T
S
V
R
A
A
F
V
H
V
L
G
D
L
L
Q
S
F
G
V
L
A
A
S
I
L
I
Y
FKPQ--YKAA
D
P
I
S
T
F
L
F
S
I
C
ALGST
A
P
T
L
R
D
-
V
L
R
I
L
M--EGTPR--NVG
F
E
P
V
R
D
T
L
LSV--PGVR
A
T
H
E
L
H
L
W
A
L
-
T
L
T
Y
H
V
A
S
A
H
L
A
ID---S---T---A
D
P
-
E
-
A
V
-
L
A
E
A
S
S
R
-----
L
Y
S
R
F-GFS
S
C
T
L
Q
V
-------
E
QY
Q
P
E
M
-----
A
Q
C
L
RCQEPPQA----------------------------------
19
Fugue
84.71
18%
-70
* C6 *
4QA5
5
HDAC8_HUMAN
A:
[14-377]
---------------------------
L
V
P
V
Y
I
Y
S
P
E
Y
V
S
M
C
D
S
L
A
K
I
P
K
--
R
A
S
M
V
H
S
L
I
E
A
Y
A
-------
L
H
K
Q
M
R
I
V
K
P
--
K
V
A
S
M
E
E
M
A
T
F
H
T
D
A
Y
L
Q
H
L
Q
K
V
S
Q
E
G
D
D
D
H
P
D
S
I
E
Y
G
L
G
Y
D
C
P
-------------------
A
T
E
G
-----------------------------------
I
F
D
Y
---------
A
A
A
I
----
G
G
A
T
I
T
A
A
Q
C
L
--
I
D
-------
G
M
C
K
V
--------
A
I
N
W
S
--
G
-------------
G
W
H
H
--
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
---------------------
R
L
R
R
--------------
K
F
E
R
-------
I
L
Y
----
V
D
LDL
H
H
G
D
G
V
E
D
T
F
---
S
F
T
-----
S
K
V
----
M
T
V
S
L
H
K
F
S
P
G
F
F
P
G
T
G
D
V
S
D
V
G
L
G
K
G
R
Y
-
Y
S
V
N
V
P
I
Q
D
GIQ
D
E
K
Y
Y
Q
I
C
E
S
V
L
K
E
V
Y
Q
A
F
N
--
P
K
A
V
V
L
Q
L
G
A
D
--
T
I
A
G
D
P
M
C
S
F
N
M
T
P
V
G
I
G
K
C
L
K
Y
I
L
Q
-
W
-------------------
Q
L
A
T
L
I
L
G
G
--
G
G
F
N
L
A
N
T
A
R
C
W
T
Y
--
L
T
G
V
I
L
G
K
T
L
------
S
---
S
---
E
I
P
-
D
-
H
E
-
F
F
T
A
Y
G
P
-----
D
Y
V
L
E
-
I
T
P
S
C
R
P
D
R
NE-----
P
H
R
I
Q
Q
I
-----
L
N
Y
I
K
G
N
L
K
H
V
V
----------------------------------
8
HHSearch
81.89
19%
-115
- C7 -
3H90
-
FIEF_ECOLI
A:
[2-283]
----------------------------------------------------------------------------------------------------------------------
V
S
R
A
A
I
A
A
T
A
M
-------------
A
S
L
L
L
L
I
K
I
-----------------------------------
F
A
W
W
---------
Y
T
G
S
----
V
S
I
L
A
A
L
V
D
S
L
--
V
D
I
G
----
A
S
L
T
N
L
--------
L
V
V
R
Y
--
S
L
Q
P
A
D
--
D
-
N
H
S
F
G
H
G
K
--
A
E
S
L
A
A
L
A
Q
S
M
F
I
S
G
S
A
L
F
L
---------------------
F
L
T
---------------
G
I
Q
H
-------
L
I
S
----
P
T
---
P
M
T
D
P
G
V
G
V
I
---
V
T
I
V
A
L
I
C
T
I
I
----
L
V
S
F
Q
R
W
V
V
R
R
-----------------------
T
Q
------
S
Q
A
V
R
A
D
M
L
H
Y
Q
S
D
V
M
M
N
G
A
I
L
L
A
L
G
L
S
W
Y
--
G
--
W
H
R
A
D
A
L
F
A
L
G
I
G
I
Y
I
L
Y
S
A
L
R
M
G
Y
E
-
A
V
Q
S
L
L
--
D
R
A
L
P
--
D
E
E
R
Q
E
I
I
D
I
V
T
S
W
--
P
G
V
S
G
A
H
D
L
R
T
R
Q
S
-
G
P
T
-
R
F
I
Q
I
H
L
E
M
E
---
D
---
S
LP
L
V
Q
A
-
H
-
M
V
-
A
D
Q
V
E
Q
A
-----
I
L
R
R
F
-
P
G
S
D
V
I
I
H
Q
-------
D
P
C
S
V
V
----------------------------------------------------
26
Fugue
77.22
13%
-95
- C8 -
1JFA
2
TRI5_FUSSP
A:
[1-354]
---------------------------
M
E
N
----
F
P
T
E
Y
F
L
N
T
T
V
R
L
L
E
Y
----------
I
R
Y
R
D
-------
S
N
Y
T
R
E
E
R
I
E
--
N
L
H
Y
A
Y
N
K
A
A
H
H
F
----
A
Q
P
R
Q
Q
Q
L
L
K
V
D
P
K
R
L
Q
A
S
----
L
Q
T
I
V
-------------
G
M
V
V
Y
S
W
A
K
-----------------------------------
V
S
K
E
---------
C
M
A
D
----
L
S
I
H
Y
T
Y
T
L
V
L
--
D
D
S
K
DDPY
P
T
M
V
N
Y
--------
F
D
D
L
Q
--
A
G
R
E
Q
A
--
H
-
P
W
W
A
L
V
N
E
H
F
P
N
V
L
R
H
F
G
P
F
C
S
L
N
L
I
R
S
T
L
---------------------
D
F
F
---------------
E
G
C
W
-------
I
E
Q
----
Y
N
---
F
G
G
F
P
G
S
--------------
H
D
Y
----
P
Q
F
L
R
R
M
N
G
--------
L
G
H
C
V
G
A
S
L
W
P
K
-
E
Q
F
N
---------
E
R
S
L
F
L
E
I
T
S
A
I
A
Q
M
E
N
W
M
V
W
V
N
D
L
M
S
F
Y
K
E
F
--
D
D
E
R
D
Q
I
S
---
L
V
K
N
Y
V
V
S
D
E
I
S
L
H
E
-
A
L
E
K
L
T
--
Q
D
T
L
H
--
S
S
--
K
Q
M
V
A
V
F
S
D
K
--
D
P
Q
V
M
D
T
I
E
C
F
M
H
G
-
Y
V
T
W
H
L
C
D
R
R
Y
R
L
S
---
E
---
I
---
Y
E
K
V
K
-
E
E
-
K
T
E
D
A
Q
K
-----
F
C
K
F
Y
-
E
Q
A
A
N
V
G
A
V
-------
S
P
S
E
W
A
Y
-----
P
P
V
A
Q
L
A
N
V
-------------------------------------
9
HHSearch
75.27
16%
-109
- C7 -
3J1Z
-
?
P:
[6-292]
-----------------------------------------------------------------------------------------------------------------
Q
Y
D
F
W
V
K
L
A
S
R
A
S
V
A
T
-------------
A
L
T
L
I
T
I
K
L
-----------------------------------
L
A
W
L
---------
Y
S
G
S
----
A
S
M
L
A
S
L
T
D
S
F
--
A
D
T
L
----
A
S
I
I
N
F
--------
I
A
I
R
Y
--
A
I
V
P
A
D
--
H
-
D
H
R
Y
G
H
G
K
--
A
E
P
L
A
A
L
A
Q
S
A
F
I
M
G
S
A
F
L
L
---------------------
L
F
Y
---------------
G
G
E
R
-------
L
L
N
----
P
S
---
P
V
E
N
A
T
L
G
V
V
---
V
S
V
V
A
I
V
L
T
L
A
----
L
V
L
L
Q
K
R
A
L
A
A
-----------------------
T
N
------
S
T
V
V
E
A
D
S
L
H
Y
K
S
D
L
F
L
N
A
A
V
L
L
A
L
V
L
S
Q
Y
--
G
--
W
W
W
A
D
G
L
F
A
V
L
I
A
C
Y
I
G
Q
Q
A
F
D
L
G
Y
R
-
S
I
Q
A
L
L
--
D
R
E
L
D
--
E
D
T
R
Q
R
I
K
L
I
A
K
E
D
--
P
R
V
L
G
L
H
D
L
R
T
R
Q
A
-
G
-
K
T
V
F
I
Q
F
H
L
E
L
D
---
G
---
N
LSL
N
E
A
-
H
-
S
I
-
T
D
T
T
G
L
R
-----
V
K
A
A
F
-
E
D
A
E
V
I
I
H
Q
-------
D
P
V
Q
V
E
P
-----
T
T
Q
-------------------------------------------
18
Fugue
73.58
18%
-83
- C7 -
2QFI
-
FIEF_ECOLI
A:
[5-290]
------------------------------------------------------------------------------------------------------------------
Y
G
R
L
V
S
R
A
A
I
A
A
T
A
M
-------------
A
S
L
L
L
L
I
K
I
-----------------------------------
F
A
W
W
---------
Y
T
G
S
----
V
S
I
L
A
A
L
V
D
S
L
--
V
D
I
G
----
A
S
L
T
N
L
--------
L
V
V
R
Y
--
S
L
Q
P
A
D
--
D
-
N
H
S
F
G
H
G
K
--
A
E
S
L
A
A
L
A
Q
S
M
F
I
S
G
S
A
L
F
L
---------------------
F
L
T
---------------
G
I
Q
H
-------
L
I
S
----
P
T
---
P
M
T
D
P
G
V
G
V
I
---
V
T
I
V
A
L
I
C
T
I
I
----
L
V
S
F
Q
R
W
V
V
R
R
-----------------------
T
Q
------
S
Q
A
V
R
A
D
M
L
H
Y
Q
S
D
V
M
M
N
G
A
I
L
L
A
--
L
G
L
S
W
Y
G
--
W
H
R
A
D
A
L
F
A
L
G
I
G
I
Y
I
L
Y
S
A
L
R
M
G
Y
E
-
A
V
Q
S
L
L
--
D
R
A
L
P
--
D
E
E
R
Q
E
I
I
D
I
V
T
S
W
--
P
G
V
S
G
A
H
D
L
R
T
R
Q
S
-
G
P
T
R
F
I
-
Q
I
H
L
E
M
E
DSL
P
---
L
---
V
Q
A
-
H
-
M
V
-
A
D
Q
V
E
Q
A
-----
I
L
R
R
F
-
P
G
S
D
V
I
I
H
Q
-------
D
P
C
S
V
V
----------------------------------------------------
23
Fugue
73.09
18%
-61
- C1 -
4NWV
-
?
A:
[30-384]
--------------------------S
V
A
P
----
V
A
K
A
N
A
L
R
T
T
S
S
N
S
I
L
--
L
K
G
----
C
D
R
I
V
T
---------
V
V
D
A
S
T
Y
D
--
A
G
S
A
I
V
S
I
P
I
T
P
-----
D
I
A
Y
R
L
G
S
T
A
R
T
F
Q
R
I
K
Y
R
S
L
K
F
R
V
N
A
Q
-------------
C
A
T
T
T
A
G
G
Y
-----------------------------------
V
A
G
F
---------
V
K
D
A
----
A
D
V
L
P
T
G
T
A
S
I
--
P
Y
L
M
----
S
N
T
G
S
F
--------
T
Q
P
W
W
--
K
S
T
V
H
N
--
V
-
K
I
P
Q
K
L
F
Y
--
T
E
A
P
T
R
G
A
D
A
V
R
E
Y
-
C
P
G
Q
F
---------------------
H
V
L
---------------
V
D
S
K
-------
P
------------------------
S
Q
I
C
P
V
T
V
D
L
E
----
W
V
V
E
L
H
D
A
T
F
R
K
E
S
D
Q
T
A
I
S
A
I
V
A
D
H
T
L
N
V
Y
G
L
P
A
T
------
S
N
R
V
G
H
I
L
I
S
P
I
G
Q
T
P
K
D
L
T
P
T
R
F
A
T
F
F
G
F
L
P
D
--
D
K
--------------
F
C
V
R
I
P
T
P
V
D
-
V
V
-
L
T
G
--
D
N
V
Y
Q
--
S
V
E
A
T
H
I
R
A
Y
L
--
V
--
N
G
-
G
L
G
I
D
F
H
L
A
A
Y
N
D
T
T
H
T
I
Q
P
I
I
P
T
L
W
---
N
---
V
---
Y
D
V
-
T
G
A
V
-
T
A
P
F
T
S
A
-----
I
Y
D
N
H
-
V
W
T
H
K
D
K
F
V
P
V
S
----
F
Q
D
E
P
I
P
-----
G
T
V
F
D
Y
L
Y
P
R
S
-----------------------------------
25
Fugue
69.12
15%
-66
* C8 *
3WDO
-
?
A:
[1-453]
------------------------DYK
M
T
P
----
G
E
R
R
A
T
W
G
L
G
T
V
F
S
L
R
--
M
L
G
M
F
M
V
L
P
V
L
T
T
-------
Y
G
M
A
L
Q
G
A
S
E
--
A
L
I
G
I
A
I
G
I
Y
G
L
-----
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
I
G
R
K
P
L
I
V
G
G
L
A
V
F
A
A
G
S
V
I
A
A
L
SDS
I
W
G
I
I
L
G
R
A
-----------------------------------
L
Q
G
S
---------
G
A
I
A
----
A
A
V
M
A
L
L
S
D
L
T
RE
Q
N
R
T
----
K
A
M
A
F
I
--------
G
V
S
F
G
--
I
T
F
A
I
A
--
M
-
V
L
G
P
I
I
T
H
--
K
L
G
L
H
A
L
F
W
M
I
A
I
L
A
T
T
G
I
A
---------------------
L
T
I
W
V
VPNS
S
T
H
V
L
N
R
E
S
G
M
V
K
-------
G
S
F
----
S
K
---
V
L
A
E
P
R
L
L
K
L
---
N
F
G
I
M
C
L
H
M
L
L
----
M
S
T
F
V
A
L
P
G
Q
L
A
D
A
G
F
P
A
A
E
H
W
K
V
Y
L
A
T
M
-
L
I
A
-
F
G
------
S
V
V
P
F
I
I
Y
A
E
V
K
R
K
M
K
Q
V
F
V
F
C
V
G
L
I
V
V
A
E
I
V
L
--
W
N
A
Q
T
Q
F
W
Q
L
V
V
G
V
Q
L
F
F
V
A
F
N
L
M
E
A
-
L
L
P
S
L
I
S
K
E
S
P
A
G
--
Y
K
G
T
A
M
G
V
Y
S
T
S
Q
F
--
L
G
V
A
I
G
G
S
L
G
G
W
I
D
-
G
M
F
----
D
G
Q
G
V
F
L
---
A
---
G
---
A
M
L
-
A
-
A
V
-
W
L
A
V
A
S
T
-----
M
K
E
P
P
-
Y
V
S
S
L
R
I
E
I
PADIAAN
E
A
L
K
V
R
L
L
E
TEG
V
K
E
V
L
I
A
E
E
E
H
S
A
Y
V
K
I
DSKVTN
R
F
E
V
E
Q
A
I
R
QAL-----------
24
Fugue
67.73
13%
-69
- C6 -
1KHV
-
POLG_RHDVF
A:
[5-501]
--------------------------F
C
G
E
----
P
I
D
Y
R
G
I
T
A
H
R
L
V
G
A
E
--
P
R
P
P
V
S
G
T
R
Y
A
K
V
P
GVPD--
E
Y
K
T
G
Y
R
P
A
N
LG
R
S
D
P
D
S
D
K
S
L
M
N
-----
I
A
V
K
N
L
Q
V
Y
Q
Q
E
P
K
L
D
K
V
D
E
F
I
E
R
A
A
A
D
-------------
V
L
G
Y
L
R
F
L
T
K
G
E
R
Q
A
N
L
N
F
K
A
A
F
N
T
LDLSTSCGPFVPGK
K
I
D
H
V
K
D
G
V
---------
M
D
Q
V
----
L
A
K
H
L
Y
K
C
W
S
V
--
A
N
S
G
----
K
A
L
H
H
I
--------
Y
A
C
G
L
KD
E
L
R
P
L
D
--
G
-
K
K
R
L
L
W
G
C
--
D
V
G
V
A
V
C
A
A
A
V
F
H
N
I
C
Y
K
L
K
M
V
ARFGPIAVGVDMTSR
D
V
D
V
I
I
N
---------------
N
L
T
S
KAS
D
F
L
C
L
D
Y
----
S
K
---
W
D
S
T
M
S
P
C
V
V
---
R
L
A
I
D
I
L
A
D
C
C
EQT
E
L
T
K
S
V
V
L
T
L
K
S
H
P
M
T
I
L
D
A
M
I
V
Q
T
K
R
G
L
P
-
S
G
M
P
--------
F
T
S
V
I
N
S
I
C
H
W
L
L
W
S
A
A
V
Y
K
S
C
A
E
I
G
L
----
H
C
--
S
N
L
Y
E
D
A
P
F
Y
T
Y
G
D
D
G
V
Y
A
M
T
P
M
M
V
S
-
L
L
P
A
I
I
--
E
N
L
R
D
---
Y
G
L
S
P
T
A
A
D
K
T
E
F
--
I
D
V
C
P
L
N
K
I
S
F
L
K
R
-
T
F
E
L
T
D
I
G
W
V
S
K
L
D
---
K
---
S
---
S
I
L
-
R
-
Q
L
E
W
S
K
T
T
S
R
-----
H
M
V
I
E
-
E
T
Y
D
L
A
K
E
E
-------
R
G
V
Q
L
E
E
-----
L
Q
V
A
A
A
A
H
G
Q
E
F
F
N
F
V
C
R
E
L
E
R
Q
Q
AYTQ
F
S
V
Y
S
Y
D
A
A
R
K
I
L
A
D
R
K
R
21
Fugue
63.91
13%
-94
- C5 -
2V4J
4
DSVB_DESVH
B:
[2-381]
----------------------------------
A
F
I
S
S
G
Y
N
P
E
K
P
M
A
N
R
IT
D
I
G
P
R
K
F
D
E
F
F
P
P
-------
V
I
A
K
N
F
G
S
W
L
--
Y
H
E
I
L
E
P
G
V
L
M
H
-----
V
A
E
S
G
---
D
K
V
Y
T
V
R
V
G
A
A
R
L
M
S
I
T
H
I
R
-------------
E
M
C
D
I
A
D
K
Y
-----------------------------------
C
G
G
H
---------
L
R
F
T
TRN
N
V
E
F
M
V
A
D
E
A
S
L
--
K
A
L
K
----
E
D
L
A
S
R
KFDGGSLK
F
P
I
G
G
--
T
G
A
G
V
S
--
N
I
V
H
T
Q
G
W
V
H
--
C
H
T
P
A
T
D
A
S
G
P
V
K
A
I
M
D
E
V
F
---------------------
E
D
F
---------------
Q
S
M
R
-------
L
-
P
----
A
P
---
V
R
I
S
L
A
C
C
I
N
---
M
C
G
A
V
H
C
S
D
------
I
G
V
V
G
I
H
R
K
P
P
M
I
D
H
E
W
T
D
Q
L
C
E
I
P
L
A
V
A
--
S
C
P
T
A
--------
A
V
R
P
T
K
L
E
I
G
D
K
K
V
N
T
I
A
I
K
N
E
R
C
M
Y
--------------
C
G
N
C
Y
T
M
C
P
A
L
P
I
S
D
G
E
G
D
-
G
V
V
I
M
V
--
G
G
K
V
S
--
N
R
I
S
M
P
K
F
S
K
V
V
V
A
--
Y
I
P
N
E
P
P
R
W
----
P
-
S
L
T
K
T
I
K
H
I
I
E
V
Y
S
---
A
---
N
---
A
Y
K
-
Y
-
E
R
-
L
G
E
W
A
E
R
I
G
W
E
R
F
F
S
L
T
-
G
L
E
F
S
H
H
L
I
-------
D
D
F
R
D
P
A
-----
Y
Y
T
W
R
Q
S
T
Q
F
K
F
----------------------------------
4
PsiBlast_PDB
61.76
19%
-108
- C7 -
3H90
-
FIEF_ECOLI
A:
[20-227]
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
I
-----------------------------------
F
A
W
W
---------
Y
T
G
S
----
V
S
I
L
A
A
L
V
D
S
L
--
V
D
I
G
----
A
S
L
T
N
L
--------
L
V
V
R
Y
--
S
L
Q
P
A
D
--
D
-
N
H
S
F
G
H
G
K
--
A
E
S
L
A
A
L
A
Q
S
M
---
F
I
S
G
S
A
---------------------
L
F
L
---------------
F
L
T
G
-------
I
Q
H
LISP
T
P
---
M
T
D
P
G
V
G
V
I
V
---
T
I
V
A
L
I
C
T
I
I
L
----
V
S
F
Q
R
W
V
V
R
R
T
Q
S
Q
------------------------------
A
V
R
A
D
M
L
H
Y
Q
S
D
V
M
M
N
G
A
I
L
L
A
L
G
L
S
W
Y
G
----
W
H
R
A
D
A
L
F
A
L
G
I
G
I
Y
I
L
Y
S
A
L
R
M
G
Y
E
-
A
V
Q
S
L
L
--
D
R
A
L
P
--
D
E
E
R
Q
E
I
I
D
I
V
T
S
W
--
P
G
V
S
G
A
H
D
L
R
T
R
Q
S
-
G
P
T
R
F
I
Q
I
H
L
E
M
E
D
---
S
---
L
---
P
L
V
-
Q
-
A
H
-
M
V
A
D
Q
V
E
-----
Q
A
I
L
R
-
R
F
P
G
S
D
V
I
I
-------
H
Q
D
P
C
S
V
-----
V
---------------------------------------------
20
Fugue
57.20
10%
-69
* C5 *
1LNS
-
PEPX_LACLC
A:
[165-550]
L
L
E
R
E
V
L
W
V
E
S
PVDSEQRG
E
N
D
L
I
K
I
Q
I
I
R
----
P
K
S
T
E
K
L
P
V
V
M
T
A
S
P
Y
--
H
L
G
I
N
D
K
A
N
D
L
A
L
HDMN
V
E
L
E
E
K
T
S
H
E
I
H
V
--
E
Q
K
L
P
Q
K
L
S
A
K
A
-----
K
E
L
P
I
V
D
K
A
P
Y
R
F
T
H
G
W
T
Y
S
L
N
D
Y
F
L
T
R
-------------
G
F
A
S
I
Y
V
A
G
-----------------------------------
V
G
T
R
S
S
D
G
F
QTSG
D
Y
Q
Q
----
I
Y
S
M
T
A
V
I
D
W
L
--
N
G
R
A
----
R
A
Y
T
S
R
--------
K
K
T
H
E
--
I
K
A
S
W
A
NG
K
-
V
A
M
T
G
K
S
Y
--
L
G
T
M
A
Y
G
A
A
T
T
G
V
E
G
L
E
L
I
L
---------------------
A
E
A
---------------
G
I
S
S
-------
W
Y
N
-----
Y
---
Y
R
E
-
N
G
L
V
R
S
PGG
F
P
G
E
D
L
D
V
L
A
A
----
L
T
Y
S
R
N
L
D
------
G
A
D
F
L
-------------------------
K
G
N
A
E
Y
E
K
R
L
A
E
M
T
A
A
L
D
R
K
S
G
D
Y
N
Q
F
W
H
D
R
NY
L
I
N
T
D
K
V
K
A
D
V
L
I
V
H
G
L
Q
D
W
N
V
T
P
E
Q
-
A
Y
N
F
W
K
--
A
L
P
E
G
--
H
------
A
K
H
A
F
L
H
--
R
G
A
H
I
Y
M
N
S
W
-------------
Q
S
I
--------------
D
F
S
-
E
-
T
I
-
N
A
Y
F
V
A
K
-----
L
L
D
R
D
-
L
N
L
N
-
L
P
P
V
-------
I
L
Q
E
N
S
K
-----
D
Q
V
W
T
M
M
N
D
F
G
A
----------------------------------
3
PsiBlast_PDB
55.99
19%
-84
- C7 -
2QFI
-
FIEF_ECOLI
A:
[27-234]
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
I
-----------------------------------
F
A
W
W
---------
Y
T
G
S
----
V
S
I
L
A
A
L
V
D
S
L
--
V
D
I
G
----
A
S
L
T
N
L
--------
L
V
V
R
Y
--
S
L
Q
P
A
D
--
D
-
N
H
S
F
G
H
G
K
--
A
E
S
L
A
A
L
A
Q
S
M
---
F
I
S
G
S
A
---------------------
L
F
L
---------------
F
L
T
G
-------
I
Q
H
LISP
T
P
---
M
T
D
P
G
V
G
V
I
V
---
T
I
V
A
L
I
C
T
I
I
L
----
V
S
F
Q
R
W
V
V
R
R
T
Q
S
Q
------------------------------
A
V
R
A
D
M
L
H
Y
Q
S
D
V
M
M
N
G
A
I
L
L
A
L
G
L
S
W
Y
G
----
W
H
R
A
D
A
L
F
A
L
G
I
G
I
Y
I
L
Y
S
A
L
R
M
G
Y
E
-
A
V
Q
S
L
L
--
D
R
A
L
P
--
D
E
E
R
Q
E
I
I
D
I
V
T
S
W
--
P
G
V
S
G
A
H
D
L
R
T
R
Q
S
-
G
P
T
R
F
I
Q
I
H
L
E
M
E
D
---
S
---
L
---
P
L
V
-
Q
-
A
H
-
M
V
A
D
Q
V
E
-----
Q
A
I
L
R
-
R
F
P
G
S
D
V
I
I
-------
H
Q
D
P
C
S
V
-----
V
---------------------------------------------
10
HHSearch
49.49
16%
-72
- C7 -
2ZZT
-
?
A:
[4-87]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
R
T
E
L
D
M
Y
D
D
I
F
A
V
L
E
R
F
--
P
N
V
H
N
P
H
R
V
R
I
R
R
V
-
G
T
--
Y
F
I
E
M
D
I
E
V
D
---
G
---
K
MS
V
K
D
A
-
H
-
E
L
-
T
V
K
I
R
K
E
-----
M
L
K
R
R
D
D
I
E
D
V
T
I
H
V
-------
E
P
L
G
N
-----------------------------------------------------
12
HHSearch
47.86
12%
-86
- C7 -
3W61
-
?
A:
[3-82]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
--
E
A
V
Q
N
R
I
V
E
A
A
E
R
V
--
P
G
V
R
G
V
I
H
L
R
A
R
Y
V
-
G
Q
D
-
I
W
A
D
M
I
I
G
V
D
---
P
ENT
V
---
E
Q
A
-
H
-
E
I
-
C
E
A
V
Q
A
A
-----
V
C
G
K
I
R
R
I
E
S
L
A
V
S
A
-------
E
A
R
E
------------------------------------------------------
1
PsiBlast_PDB
43.63
26%
-63
- C7 -
3LGD
2
CECR1_HUMAN
A:
[156-249]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
R
N
F
T
L
V
T
Q
H
P
E
V
I
Y
T
N
Q
--
N
V
V
W
S
K
F
E
T
I
F
F
T
I
S
G
L
I
H
Y
A
P
V
F
R
D
Y
V
F
R
S
M
Q
--
E
F
Y
E
D
--
N
V
L
Y
M
E
I
R
A
R
L
L
P
V
--
Y
E
L
S
G
E
H
H
D
E
E
W
S
V
-
K
T
Y
Q
E
V
A
Q
K
F
V
E
T
H
---
P
---
E
---
F
I
G
-
I
-
K
I
-
I
Y
S
D
H
R
S
-----
K
D
V
A
V
-
I
A
E
S
I
R
M
A
M
-------
G
L
R
I
K
F
P
-----
T
V
V
A
G
F
D
L
V
G
H
E
----------------------------------
2
PsiBlast_PDB
43.45
26%
-57
- C7 -
3LGG
3
CECR1_HUMAN
A:
[156-249]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
R
N
F
T
L
V
T
Q
H
P
E
V
I
Y
T
N
Q
--
N
V
V
W
S
K
F
E
T
I
F
F
T
I
S
G
L
I
H
Y
A
P
V
F
R
D
Y
V
F
R
S
M
Q
--
E
F
Y
E
D
--
N
V
L
Y
M
E
I
R
A
R
L
L
P
V
--
Y
E
L
S
G
E
H
H
D
E
E
W
S
V
-
K
T
Y
Q
E
V
A
Q
K
F
V
E
T
H
---
P
---
E
---
F
I
G
-
I
-
K
I
-
I
Y
S
D
H
R
S
-----
K
D
V
A
V
-
I
A
E
S
I
R
M
A
M
-------
G
L
R
I
K
F
P
-----
T
V
V
A
G
F
D
L
V
G
H
E
----------------------------------
11
HHSearch
43.33
18%
-47
- C7 -
3BYP
-
?
A:
[6-87]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
P
--
P
E
E
V
E
R
I
R
A
F
L
Q
E
R
I
R
G
R
A
L
E
V
H
D
L
K
T
R
R
A
-
G
P
R
-
S
F
L
E
F
H
L
V
V
R
---
G
---
D
TP
V
E
E
A
-
H
-
R
L
-
C
D
E
L
E
R
A
-----
L
A
Q
A
F
-
P
G
L
Q
A
T
I
H
V
-------
E
P
E
G
------------------------------------------------------
14
HHSearch
39.42
25%
-103
- C7 -
3H90
-
FIEF_ECOLI
A:
[116-202]
----------------------------------------------------------------------------------------------------------------------------
V
A
L
I
C
-------------
T
I
I
L
V
S
F
Q
R
-----------------------------------
W
V
V
R
---------
R
T
Q
S
----
Q
A
V
R
A
D
M
L
H
Y
Q
--
S
D
V
M
----
M
N
G
A
I
L
--------
L
A
L
G
L
--
S
W
-----------
Y
G
W
H
R
--
A
D
A
L
F
A
L
G
I
G
I
Y
I
L
Y
S
A
L
R
M
---------------------
G
Y
E
---------------
A
V
Q
S
-------
L
L
D
----
R
A
---
L
P
D
E
E
R
Q
E
I
I
---
D
I
V
T
S
W
P
G
V
S
G
----
A
H
D
L
R
T
R
Q
S
G
P
T
R
F
I
Q
I
H
L
E
M
E
D
S
L
P
L
V
Q
-
A
H
M
V
A
D
------
Q
V
E
Q
A
I
L
R
R
F
P
G
S
D
V
I
I
H
Q
D
P
C
S
V
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
HHSearch
33.29
19%
-80
- C7 -
3J1Z
-
?
P:
[129-211]
--------------------------------------------------------------------------------------------------------------------------------
L
-------------
T
L
A
L
V
L
L
Q
K
-----------------------------------
R
A
L
A
---------
A
T
N
S
----
T
V
V
E
A
D
S
L
H
Y
K
--
S
D
L
F
----
L
N
A
A
V
L
--------
L
A
L
V
L
--
S
Q
-----------
Y
G
W
W
W
--
A
D
G
L
F
A
V
L
I
A
C
Y
I
G
Q
Q
A
F
D
L
---------------------
G
Y
R
---------------
S
I
Q
A
-------
L
L
D
----
R
E
---
L
D
E
D
T
R
Q
R
I
K
---
L
I
A
K
E
D
P
R
V
L
G
----
L
H
D
L
R
T
R
Q
A
G
K
T
V
F
I
Q
F
H
L
E
L
D
G
N
L
S
L
N
E
-
A
H
S
I
T
D
------
T
T
G
L
R
V
K
A
A
F
E
D
A
E
V
I
I
H
Q
D
P
V
Q
V
E
P
T
T
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
30.62
30%
128
- C3 -
2KCZ
-
?
A:
[95-136]
-----------------------------
P
----
A
P
G
A
R
G
T
E
V
V
V
R
L
T
Y
R
--
P
P
G
G
S
A
G
A
V
I
A
R
M
-------
F
N
Q
E
P
S
Q
Q
L
R
--
D
D
L
M
R
F
K
R
E
Q
E
L
-----
G
L
E
H
H
H
H
H
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------