@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ZNT7_HUMAN: (2015-12-12 )
MLPLSIKDDEYKPPKFNLFGKISGWFRSILSDKTSRNLFFFLCLNLSFAFVELLYGIWSNCLGLISDSFHMFFDSTAILAGLAASVISKWRDNDAFSYGYVRAEVLAGFVNGLFLIFTAFFIFSEGVERALAPPDVHHERLLLVSILGFVVNLIGIFVFKHGGHGHSHGSGHGHSHSLFNGALDQAHGHVDHCHSHEVKHGAAHSHDHAHGHGHFHSHDGPSLKETTGPSRQILQGVFLHILADTLGSIGVIASAIMMQNFGLMIADPICSILIAILIVVSVIPLLRESVGILMQRTPPLLENSLPQCYQRVQQLQGVYSLQEQHFWTLCSDVYVGTLKLIVAPDADARWILSQTHNIFTQAGVRQLYVQIDFAAM
Atome Classification :
(20 SA)
----------------------------------------------------------------------.........10.----------------.......20........30........40........50...-.....60........70........80........90........100.....-.----.-------110.......---120..-.....130......-.140..-----...---------...150....-----...160-----......---..170.......180.......190.......200.......210.--------------------......220....-...230-----.........240--.....--...250.-......260-...---.-------...270.......280.....--..290....------------------------...--300.......310-----...--....320---.......330........340----------...---.---.---...350-.....-....360-....---------------...370....-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------------------------------MLPLSIKDDEYK----------------PPK
F
N
L
F
G
K
I
S
G
W
F
R
S
I
L
SDKTSR
N
L
F
F
F
L
C
L
N
L
S
F
A
F
V
E
L
L
-
Y
G
I
W
S
N
C
L
G
L
I
SD
S
F
H
M
F
FD
S
T
A
I
L
A
G
L
A
A
S
V
I
S
K
WRDNDAF
S
Y
G
Y
V
R
A
E
V
L
A
-
G
----
F
-------
V
N
G
L
F
L
I
F
T
A
---
F
F
I
F
S
-
E
G
V
E
RALAPPD
V
H
H
-
E
R
L
-
L
L
-----
V
S
I
---------
L
G
F
V
V
N
L
I
G
I
-----
F
V
FKH------GGHGHS---HGSGHGHS
H
S
L
F
NG
A
L
D
QAHGHVDHCHSHEVKHGAAHSHDHAHGHG--------------------HFHSHDGPSLKET-TG
P
S
-------
R
Q
I
L
Q
G
V
F
L
H
I
---
L
A
D
T
L--G
S
I
G
V
I
A
-
S
A
I
M
M
Q
NFG-
L
M
I
---
A
-------
D
P
I
C
S
I
L
I
A
I
L
I
V
V
S
V
I
P
L
L
R
--
E
S
V
G
I
L
M
QR------------------------TP
P
--
L
L
E
N
S
L
P
Q
C
Y
Q
R
V
-----
Q
Q
L
--
Q
G
V
Y
S
L
Q
---
E
Q
H
F
W
T
L
C
-
S
D
V
Y
V
G
T
L
K
L
I
-----------VAP---D---A---D
A
R
W
---
I
L
S
Q
T
-
H
N
I
F
T
Q
A-GV
R
Q
---------------
L
Y
V
Q
I
D
FAAM-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
HHSearch
91.83
19%
-123
- C2 -
3J1Z
-
?
P:
[7-290]
-------------------------------------------------------------------------------------------------------------------
Y
D
F
W
V
K
L
A
S
R
A
S
V
A
T
A
L
T
L
I
T
I
K
L
L
-
A
W
L
Y
S
G
S
A
S
M
L
A
S
L
T
D
S
F
A
D
T
L
A
S
I
I
N
F
I
A
I
R
Y
A
I
V
P
A
D
H
D
H
R
Y
G
H
G
K
A
E
P
L
A
-
A
----
L
-------
A
Q
S
A
F
I
M
G
S
A
---
F
L
L
L
F
-
Y
G
G
E
R
L
L
N
P
S
P
V
E
N
A
T
L
G
-
V
V
-----
V
S
V
---------
V
A
I
V
L
T
L
A
L
V
-----
L
L
Q
K
R
------
A
L
---------------------------------------------------------------------------------------
A
A
T
N
-------
S
T
V
V
E
A
D
S
L
H
Y
---
K
S
D
L
F
--
L
N
A
A
V
L
L
-
A
L
V
L
S
Q
-
Y
G
-
W
W
W
---
A
-------
D
G
L
F
A
V
L
I
A
C
Y
I
G
Q
Q
A
F
D
L
G
Y
--
R
S
I
Q
A
L
L
D
R
------------------------
E
L
D
--
E
D
T
R
Q
R
--
I
K
L
I
A
-----
K
E
D
--
P
R
V
L
G
L
H
---
D
L
R
T
R
Q
A
G
-
K
T
V
F
-
I
Q
F
H
L
E
-----------
L
D
G
---
N
LSL
N
---
E
A
H
S
---
I
T
D
T
T
G
L
R
V
K
A
A
F
-
E
D
A
E
---------------
V
I
I
H
Q
D
P
V
Q
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
83.91
17%
-127
- C2 -
3H90
-
FIEF_ECOLI
A:
[2-281]
-----------------------------------------------------------------------------------------------------------------------
V
S
R
A
A
I
A
A
T
A
M
A
S
L
L
L
L
I
K
I
F
-
A
W
W
Y
T
G
S
V
S
I
L
A
A
L
V
D
S
L
V
D
I
G
A
S
L
T
N
L
L
V
V
R
Y
S
L
Q
P
A
D
D
N
H
S
F
G
H
G
K
A
E
S
L
A
-
A
----
L
-------
A
Q
S
M
F
I
S
G
S
A
---
L
F
L
F
L
-
T
G
I
Q
H
L
I
S
P
T
P
M
T
D
P
G
V
G
-
V
I
-----
V
T
I
---------
V
A
L
I
C
T
I
I
L
V
-----
S
F
Q
R
W
------
V
V
---------------------------------------------------------------------------------------
R
R
T
Q
-------
S
Q
A
V
R
A
D
M
L
H
Y
---
Q
S
D
V
M
--
M
N
G
A
I
L
L
-
A
L
G
L
S
W
-
Y
G
-
W
H
R
---
A
-------
D
A
L
F
A
L
G
I
G
I
Y
I
L
Y
S
A
L
R
M
G
Y
--
E
A
V
Q
S
L
L
D
R
------------------------
A
L
P
--
D
E
E
R
Q
E
--
I
I
D
I
V
-----
T
S
W
--
P
G
V
S
G
A
H
---
D
L
R
T
R
Q
S
G
-
P
T
R
F
I
-
Q
I
H
L
E
-----------
M
E
D
---
S
LP
L
V
---
Q
A
H
M
---
V
A
D
Q
V
E
Q
A
I
L
R
R
F
-
P
G
S
D
---------------
V
I
I
H
Q
D
P
C
S
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Fugue
78.64
12%
-87
- C4 -
2B1X
7
?
A:
[1-441]
-------------------------------------------MLS
N
E
L
R
Q
T
L
Q
K
G
L
H
D
V
N
S
DWTVPAAI
I
N
D
P
E
V
H
D
V
E
R
E
R
IFGH
A
W
V
F
L
A
HESEI
P
E
R
G
D
Y
V
V
R
Y
I
S
E
D
Q
F
I
V
C
R
D
E
G
G
E
I
R
G
H
L
N
-
A
C
R
H
R
G
M
Q
V
C
-
R
A
E
M
G
N
T
S
H
F
R
C
P
Y
H
G
W
T
Y
S
N
T
G
S
L
V
G
V
P
A
G
K
D
A
Y
G
N
Q
L
K
K
S
D
W
N
L
R
P
M
P
N
L
A
-
S
----
Y
-------
K
G
---
L
I
F
G
S
---
L
D
P
H
A
-
D
S
L
E
D
Y
L
G
D
L
K
F
Y
L
-
D
I
V
-
L
D
RSDAG
L
Q
V
---------
V
G
A
P
Q
R
W
V
I
D
-----
A
N
W
K
L
------
G
A
D
N
F
V
GDA
Y
H
T
M
M
T
H
R
S
M
V
E
L
G
L
A
P
P
D
P
Q
F
A
L
Y
G
E
H
I
H
T
G
H
G
--------
H
G
L
G
--------------------
I
I
G
P
P
P
G
M
P
L
P
E
F
-
M
G
L
P
-------
E
N
I
V
E
E
L
E
R
R
L
T
P
E
Q
V
E
I
F
--
R
P
T
A
F
I
H
-
G
T
V
F
P
N
L
S
I
-
G
N
F
---
L
M
G
KDHLS
A
P
T
A
F
L
T
L
R
L
W
H
P
L
G
P
D
K
M
E
V
--
M
S
F
F
L
V
E
K
D
------------------------
A
P
D
--
W
F
K
D
E
S
Y
K
S
Y
L
R
T
-----
F
G
I
--
S
G
G
F
E
Q
D
---
D
A
E
N
W
R
S
I
-
T
R
V
M
G
G
Q
F
A
K
T
G
E
L
N
YQMGRGV
L
E
P
---
D
---
P
---
N
W
T
G
---
P
G
E
A
Y
-
P
L
D
Y
A
E
A
-
N
Q
R
N
---------------
F
L
E
Y
W
M
Q
L
M
L
AESPL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Fugue
76.57
14%
-83
- C2 -
2QFI
-
FIEF_ECOLI
A:
[5-290]
-------------------------------------------------------------------------------------------------------------------
Y
G
R
L
V
S
R
A
A
I
A
A
T
A
M
A
S
L
L
L
L
I
K
I
F
-
A
W
W
Y
T
G
S
V
S
I
L
A
A
L
V
D
S
L
V
D
I
G
A
S
L
T
N
L
L
V
V
R
Y
S
L
Q
P
A
D
D
N
H
S
F
G
H
G
K
A
E
S
L
A
-
A
----
L
-------
A
Q
S
M
F
I
S
G
S
A
---
L
F
L
F
L
-
T
G
I
Q
H
L
I
S
P
T
P
M
T
D
-
P
G
V
------------------------------------------------------------
G
V
I
V
T
I
V
A
L
I
C
T
I
I
L
V
S
F
Q
R
W
V
V
R
R
T
Q
S
Q
A
-----------------------------------------------------------
V
R
A
D
M
L
H
Y
---
Q
S
D
V
M
--
M
N
G
A
I
L
L
-
A
-
L
G
L
S
W
Y
G
-
W
H
R
---
A
-------
D
A
L
F
A
L
G
I
G
I
Y
I
L
Y
S
A
L
R
M
G
Y
--
E
A
V
Q
S
L
L
D
R
------------------------
A
L
P
----
D
E
E
R
Q
E
I
I
D
I
V
-----
T
S
W
--
P
G
V
S
G
A
H
---
D
L
R
T
R
Q
S
G
-
P
T
R
F
I
Q
I
H
L
E
M
EDS--------
L
P
L
---
V
---
Q
---
A
H
M
V
---
A
D
Q
V
E
-
Q
A
I
L
R
R
F
-
P
G
S
D
---------------
V
I
I
H
Q
D
P
C
S
V
V------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
Fugue
72.16
15%
-89
- C3 -
5DA0
2
?
A:
[14-484]
QREWFAN
P
R
K
D
V
L
A
G
I
V
V
A
L
A
L
I
P
E
A
I
A
F
S
I
I
A
GVD
P
Q
V
G
L
Y
A
S
F
I
I
A
L
I
T
A
F
LGGRPG
M
I
S
A
A
T
G
A
M
A
L
L
M
T
G
L
V
K
D
H
G
------------------
I
Q
Y
L
F
A
A
T
V
L
T
G
V
L
Q
V
V
F
G
W
A
K
L
A
R
Y
L
K
F
V
P
R
S
V
M
V
G
F
V
N
A
L
A
I
L
I
F
M
A
Q
L
P
Q
F
V
G
A
N
W
Q
M
Y
A
M
V
A
A
G
L
A
I
I
Y
L
L
P
L
V
F
K
A
M
P
S
A
L
V
A
I
V
V
L
T
V
V
A
-
V
----
V
T
GADVKT
V
G
D
M
G
T
L
P
T
A
---
L
P
H
F
Q
F
P
Q
V
P
L
T
F
E
T
L
A
I
I
F
-
P
V
A
-
L
T
-----
L
S
L
---------
V
G
L
L
E
S
L
L
T
A
-----
Q
L
I
D
E
R
TDTTS
D
K
N
V
E
S
---
R
G
Q
G
V
A
N
I
V
T
G
F
F
G
G
M
---
A
G
C
A
M
I
G
Q
S
M
I
N
V
T
S
G
G
R
G
R
L
S
T
F
V
A
G
--------------------
A
F
L
M
V
L
I
L
A
L
Q
P
L
L
V
Q
I
P
-------
M
A
A
L
V
A
V
M
M
V
V
---
A
I
S
T
F
DW
G
S
L
R
F
P
K
-
G
E
T
V
V
M
L
A
T
-
V
A
V
---
T
-------
V
F
T
H
D
L
S
L
G
V
L
I
G
V
V
L
S
A
L
F
F
--
A
R
K
V
S
Q
L
S
Q
------------------------
V
T
P
--
V
D
E
V
D
G
T
R
T
Y
R
V
R
-----
G
Q
L
--
F
F
V
S
T
H
D
---
F
L
H
Q
F
D
F
T
-
H
P
A
R
R
V
V
I
D
L
S
-----------
D
A
H
F
W-
D
---
G
---
S
A
V
G
---
A
L
D
K
V
-
M
L
K
F
M
R
Q
-
G
T
S
V
---------------
E
L
R
G
L
N
A
A
S
A
T
LVERL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Fugue
68.89
11%
-122
- C3 -
1LW3
-
MTMR2_HUMAN
A:
[77-589]
---------------------------------EEPPLLPGENIK
D
M
A
K
DVTYICPFT
G
A
V
R
G
T
L
T
V
T
NY
R
L
Y
F
K
S
M
E
R
D
P
P
----------------
F
V
L
D
A
S
L
G
V
I
N
R
V
E
K
I
G
G
A
S
S
R
G
E
N
S
Y
G
L
E
T
V
C
K
D
I
R
N
L
R
F
A
-
H
K
P
E
G
R
T
R
R
S
I
F
E
N
L
M
K
Y
A
F
P
V
S
N
N
L
P
L
F
A
F
E
Y
K
E
V
F
P
E
N
G
W
K
L
Y
D
P
L
L
E
Y
R
R
Q
G
----
I
-------
P
N
E
S
W
R
I
T
K
I
NER
Y
E
L
C
D
-
T
Y
P
A
L
L
V
V
P
A
N
I
P
D
-
E
E
L
-
K
R
-----
V
A
S
F
R
SRGRIPV
L
S
W
I
H
P
E
S
Q
A
-----
T
I
T
R
C
------
S
Q
P
M
V
G
---
V
S
G
K
R
S
K
E
D
E
K
Y
L
Q
A
I
M
D
S
N
A
Q
S
H
K
I
F
I
F
D
A
R
P
S
V
N
A
V
A
N
K
A
K
G
G
G
YESEDAYQN
A
E
L
V
F
LDIHN
I
H
V
M
R
E
S
L
R
K
L
K
E
I
-
V
Y
P
N
IEETH
W
L
S
N
L
E
S
T
H
W
L
E
H
---
I
K
L
I
L
--
A
G
A
L
R
I
A
-
D
K
V
E
S
G
K
T
S
-
V
V
V
H
S
S
D
-------
G
W
D
R
T
A
Q
L
T
S
L
A
M
L
M
L
D
G
Y
Y
R
T
I
R
G
F
E
V
L
V
E
K
EWLSFGHR
F
Q
L
R
V
GHGDKNHADAD
R
S
P
--
V
F
L
Q
F
I
D
C
V
W
Q
M
T
-----
R
Q
F
--
P
T
A
F
E
F
N
---
E
Y
F
L
I
T
I
L
-
D
H
L
Y
S
C
L
F
G
T
F
-----------
L
C
N
---
S
---
E
---
Q
Q
R
G
K
E
N
L
P
K
R
T
-
V
S
L
W
S
Y
I
-
N
S
Q
L
EDFTNPLYGSYSNH
V
L
Y
P
V
A
S
M
R
H
L
ELWVGYYIRWNPR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Fugue
65.77
10%
-109
- C3 -
2VGL
-
AP2B1_HUMAN
B:
[4-582]
-----------------------------------------SKYFTTNKKG
E
I
F
E
L
K
A
E
L
N
NEK
K
E
K
R
K
E
A
V
K
K
V
I
A
A
M
T
V
G
----------------
K
D
V
S
S
L
F
P
D
V
V
N
C
M
Q
T
--
D
N
L
E
L
K
K
L
V
Y
L
Y
L
M
N
Y
A
K
S
Q
P
D
M
A
-
I
M
A
V
N
S
F
V
K
D
C
E
D
P
-------
N
P
L
I
R
A
L
A
V
R
T
M
G
C
I
R
V
D
K
I
T
E
Y
L
C
E
P
L
R
K
C
L
-
K
DED
P
Y
-------
V
R
K
T
A
A
V
C
V
A
---
K
L
H
D
I
-
N
A
Q
M
V
E
D
Q
G
F
L
D
S
L
-
R
D
L
-
I
A
-----
D
S
N
---------
P
M
V
V
A
N
A
V
A
A
-----
L
S
E
I
S
------
E
S
H
--
P
---
N
S
N
L
L
D
L
N
P
Q
N
I
N
K
L
L
T
A
L
N
E
C
T
E
W
G
Q
I
F
I
L
D
C
L
S
N
Y
N
P
K
D
D
R
E
A
Q
--------------------
S
I
C
E
R
V
T
P
R
L
S
H
A
-
N
--------------
S
A
V
V
L
S
A
---
V
K
V
L
M
--
K
F
L
E
L
L
P
K
D
S
D
Y
Y
N
M
L
L
-
K
K
L
---
A
-------
P
P
L
V
T
L
L
S
G
---
E
P
E
V
Q
Y
V
A
L
--
R
N
I
N
L
I
V
Q
K
------------------------
R
P
E
--
I
L
K
Q
E
I
K
V
F
F
V
K
Y
-----
N
D
P
--
I
Y
V
K
L
E
K
---
L
D
I
M
I
R
L
A
-
S
Q
A
N
I
A
Q
V
L
A
E
-----------
L
K
E
Y
A
T
E
---
V
---
D
V
D
F
---
V
R
K
A
V
-
R
A
I
G
R
C
A
-
I
K
V
E
---------------
Q
S
A
E
R
C
V
S
T
L
L
D
L
I
Q
T
KV
N
Y
V
V
Q
E
A
I
V
V
I
R
D
I
F
R
K
YPNKYESI
I
A
T
L
C
E
N
LDSLDE
P
D
A
R
A
A
M
I
W
I
V
G
E
YAERIDNAD
E
L
L
E
S
F
L
EGFHDES
T
Q
V
Q
L
T
L
L
T
A
I
V
K
L
F
L
K
KP
S
E
T
Q
E
L
V
QQVLSLATQDSDN
P
D
L
R
D
R
G
Y
I
Y
W
R
L
LSTDPV
T
A
K
E
V
V
LSEKPLISEETDLIE
P
T
L
L
D
E
L
I
C
H
IGS
L
A
S
V
Y
HKPPNAFV
28
Fugue
56.31
10%
-73
- C4 -
3HAM
3
?
A:
[1-299]
----------------------------------------------------------------------
M
V
N
L
D
A
E
I
Y
E
H
L
----------------
N
K
Q
I
K
I
N
E
-----
L
R
Y
L
S
S
G
D
D
S
D
T
F
L
C
N
E
Q
Y
V
V
K
V
P
K
R
D
-----------------------------
S
V
R
I
S
Q
K
R
E
F
E
L
Y
R
F
L
E
N
C
K
L
S
Y
Q
I
P
A
-
V
----
V
-------
Y
Q
S
D
R
F
N
I
M
K
---
Y
I
K
G
E
-
R
I
T
Y
E
Q
Y
H
K
L
S
E
K
E
-
K
D
A
-
L
A
-----
Y
D
E
---------
A
T
F
L
K
E
L
H
S
I
-----
E
I
-
D
C
------
S
V
S
L
F
S
---
D
A
L
V
N
K
K
D
K
F
L
Q
D
K
K
L
L
I
S
I
L
E
K
E
Q
L
L
T
D
E
M
L
E
H
I
E
T
I
Y
E
N
I
L
N
N
A
--------------------
V
L
F
K
Y
T
P
C
L
V
H
N
D
-
F
S
A
N
-------
N
M
I
F
R
N
N
R
L
F
G
---
V
I
D
-------------------
F
G
D
F
N
V
---
G
-------
D
P
D
N
D
F
L
C
L
L
D
C
-------------------------------------------------
S
T
D
D
F
G
K
E
F
G
R
K
V
-----
L
K
Y
--
Y
Q
H
K
A
P
E
---
V
A
E
R
K
A
E
L
-
N
D
V
Y
W
S
I
D
Q
I
I
-----------
Y
G
Y
---
E
---
R
---
K
D
R
E
---
M
L
I
K
G
-
V
S
E
L
L
Q
T
-
Q
A
E
M
---------------
F
I
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
47.76
25%
-84
- C2 -
3J1Z
-
?
P:
[23-118]
-----------------------------------------------------------------------------------------------------------------------------------
L
T
L
I
T
I
K
L
L
-
A
W
L
Y
S
G
S
A
S
M
L
A
S
L
T
D
S
F
A
D
T
L
A
S
I
I
N
F
I
A
I
R
Y
A
I
V
P
A
D
H
D
H
R
Y
G
H
G
K
A
E
P
L
A
-
A
----
L
-------
A
Q
S
A
F
I
M
G
S
A
---
F
L
L
L
F
-
Y
G
G
E
R
L
L
N
P
S
P
V
E
N
-
A
T
L
-
G
V
-----
V
V
S
---------
V
V
A
I
V
L
T
L
A
L
-----
V
L
L
Q
K
------
R
A
L
A
A
T
---
N
S
T
V
V
E
A
D
S
L
H
Y
K
S
D
L
F
L
N
A
A
V
L
L
A
L
V
L
S
Q
Y
G
W
W
W
A
D
G
L
F
A
V
L
I
A
C
--------------------
Y
I
G
Q
Q
A
F
D
L
G
Y
R
S
-
I
Q
A
L
-------
L
D
R
E
L
D
E
D
T
R
Q
---
R
I
K
L
I
--
A
K
E
D
P
R
V
-
L
G
L
H
D
L
R
T
R
-
Q
A
G
---
K
-------
T
V
F
I
Q
F
H
L
E
L
D
G
N
L
S
L
N
E
A
H
S
--
I
T
D
T
T
G
L
R
V
------------------------
K
A
A
--
F
E
D
A
E
V
I
I
H
Q
D
P
V
-----
Q
V
E
--
P
T
T
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
HHSearch
47.40
12%
-117
- C2 -
3W61
-
?
A:
[5-82]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Q
N
R
--
I
V
E
A
A
-----
E
R
V
--
P
G
V
R
G
V
I
---
H
L
R
A
R
Y
V
G
-
Q
D
I
W
A
-
D
M
I
I
G
-----------
V
D
P
---
E
NT
V
E
---
Q
A
H
E
---
I
C
E
A
V
Q
A
A
V
C
G
K
I
R
R
I
E
S
---------------
L
A
V
S
A
E
A
R
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
HHSearch
46.54
8%
-95
- C2 -
2ZZT
-
?
A:
[4-86]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
R
T
E
L
D
M
Y
D
D
--
I
F
A
V
L
-----
E
R
F
--
P
N
V
H
N
P
H
---
R
V
R
I
R
R
V
G
-
T
-
Y
F
-
I
E
M
D
I
E
-----------
V
D
G
---
K
---
M
S
V
K
D
A
H
E
---
L
T
V
K
I
R
K
E
M
L
K
R
R
D
D
I
E
D
---------------
V
T
I
H
V
E
P
L
G
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
45.39
23%
-43
- C2 -
3H90
-
FIEF_ECOLI
A:
[61-162]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
N
H
S
F
G
H
G
K
A
E
S
L
A
-
A
----
L
-------
A
Q
S
M
F
I
S
G
S
A
---
L
F
L
F
L
-
T
G
I
Q
H
L
I
S
P
T
P
M
T
D
-
P
G
V
G
V
I
-----
V
T
I
---------
V
A
L
I
C
T
I
I
L
V
S
F
Q
R
W
V
V
R
R
T
------
Q
S
Q
A
V
R
---
A
D
M
L
H
Y
Q
S
D
V
M
M
N
G
A
I
L
L
A
L
G
L
S
W
Y
G
W
H
R
A
D
A
L
F
A
L
G
I
G
I
Y
I
L
Y
S
A
--------------------
L
R
M
G
Y
E
A
V
Q
S
L
L
D
-
R
A
L
P
-------
D
E
E
R
Q
E
I
I
D
I
V
---
T
S
W
P
G
--
V
S
G
A
H
D
L
-
R
T
R
Q
S
G
P
T
R
-
F
I
Q
---
I
-------
H
L
E
M
E
D
S
L
P
L
V
Q
A
H
M
V
A
D
Q
V
E
--
Q
A
I
L
R
R
F
P
G
------------------------
S
D
V
--
I
I
H
Q
D
P
C
S
V
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
45.06
12%
-67
- C2 -
3BYP
-
?
A:
[6-87]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
P
--
P
E
E
V
E
R
--
I
R
A
F
L
-----
Q
E
R
I
R
G
R
A
L
E
V
H
---
D
L
K
T
R
R
A
G
-
P
R
S
-
F
L
E
F
H
L
V
-----------
V
R
G
---
D
TP
V
E
---
E
A
H
R
---
L
C
D
E
L
E
R
A
L
A
Q
A
F
-
P
G
L
Q
---------------
A
T
I
H
V
E
P
E
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
43.46
34%
63
- C5 -
4RWF
2
A:
[488-531]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
C
Y
Q
K
I
M
Q
D
PI
Q
Q
A
--
E
G
V
Y
C
N
R
---
T
W
D
G
W
L
C
W
-
N
D
V
A
A
G
T
E
S
M
Q
-----------
L
C
P
---
D
---
Y
---
F
Q
D
F
---
D
P
S
E
K
-
V
T
K
I
C
D
Q
-
D
G
N
W
---------------
F
R
H
P
A
S
N
R
T
W
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
43.37
34%
32
- C5 -
4RWG
-
CALRL_HUMAN (first)
A:
[490-533]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
C
Y
Q
K
I
M
Q
DPI
Q
Q
A
--
E
G
V
Y
C
N
R
---
T
W
D
G
W
L
C
W
-
N
D
V
A
A
G
T
E
S
M
Q
-----------
L
C
P
---
D
---
Y
---
F
Q
D
F
---
D
P
S
E
K
-
V
T
K
I
C
D
Q
-
D
G
N
W
---------------
F
R
H
P
A
S
N
R
T
W
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
43.33
18%
-59
- C2 -
3HRD
1
NDLMS_EUBBA
A:
[78-165]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
R
F
G
-
I
I
I
---
K
-------
D
E
P
C
-------
L
V
D
D
K
V
R
R
Y
G
--
D
A
I
A
V
V
A
A
Q
------------------------
T
P
D
--
L
V
Q
E
A
L
D
A
I
T
I
E
Y
-----
E
E
L
--
E
G
I
F
T
M
E
R
A
L
E
E
D
S
P
A
I
H
-
G
D
T
N
I
H
Q
V
K
H
L
-----------
E
Y
G
---
D
---
V
---
D
A
A
F
---
K
Q
C
D
I
-
V
V
E
D
T
Y
S
-
T
H
R
L
---------------
T
H
M
F
I
E
P
D
A
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
43.12
21%
-111
- C2 -
3UX4
1
UREI_HELPJ
A:
[2-50]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
V
L
L
Y
V
G
---
I
V
L
I
S
-
N
G
I
C
G
L
T
K
V
D
P
K
S
T
A
V
M
N
-
F
F
-----
V
G
G
---------
L
S
I
V
C
N
V
V
V
I
-----
T
Y
S
A
L
------
H
P
T
A
P
S
---
F
Y
G
P
A
T
G
L
L
F
G
F
T
Y
L
Y
A
A
I
N
H
T
F
G
L
D
W
R
P
Y
S
W
Y
S
L
F
V
A
I
N
T
V
P
A
A
I
--------------------
L
S
H
Y
S
D
M
L
D
D
H
K
V
-
L
G
I
T
-------
E
G
D
W
W
A
I
I
W
L
A
---
W
G
V
L
W
--
L
T
A
F
I
E
N
-
I
L
K
I
P
L
G
K
F
-
T
P
W
---
L
-------
A
I
I
E
G
I
L
T
A
W
I
P
A
W
L
L
F
I
Q
H
W
--
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
42.81
24%
-56
- C2 -
3H90
-
FIEF_ECOLI
A:
[132-203]
----------------------------------------------------------------------------------------------------------------------------------------------
V
R
R
T
Q
S
Q
A
V
R
A
D
M
L
H
Y
Q
S
D
V
M
M
N
G
A
I
L
L
A
L
G
L
S
W
--------
Y
G
W
H
R
A
D
A
L
F
-
A
----
L
-------
G
I
G
I
Y
I
L
Y
S
A
---
L
R
M
G
Y
-
E
A
V
Q
S
L
L
D
R
A
L
P
D
E
-
E
R
Q
-
E
I
-----
I
D
I
---------
V
T
S
W
P
G
V
S
G
A
-----
H
D
L
R
T
------
R
Q
S
G
P
T
---
R
F
I
Q
I
H
L
E
M
E
D
S
L
P
L
V
Q
A
H
M
V
A
D
Q
V
E
Q
A
I
L
R
R
F
P
G
S
D
V
I
I
H
Q
D
P
C
S
--------------------
V
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
42.23
23%
-49
- C2 -
2QFI
-
FIEF_ECOLI
A:
[68-169]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
N
H
S
F
G
H
G
K
A
E
S
L
A
-
A
----
L
-------
A
Q
S
M
F
I
S
G
S
A
---
L
F
L
F
L
-
T
G
I
Q
H
L
I
S
P
T
P
M
T
D
-
P
G
V
G
V
I
-----
V
T
I
---------
V
A
L
I
C
T
I
I
L
V
S
F
Q
R
W
V
V
R
R
T
------
Q
S
Q
A
V
R
---
A
D
M
L
H
Y
Q
S
D
V
M
M
N
G
A
I
L
L
A
L
G
L
S
W
Y
G
W
H
R
A
D
A
L
F
A
L
G
I
G
I
Y
I
L
Y
S
A
--------------------
L
R
M
G
Y
E
A
V
Q
S
L
L
D
-
R
A
L
P
-------
D
E
E
R
Q
E
I
I
D
I
V
---
T
S
W
P
G
--
V
S
G
A
H
D
L
-
R
T
R
Q
S
G
P
T
R
-
F
I
Q
---
I
-------
H
L
E
M
E
D
S
L
P
L
V
Q
A
H
M
V
A
D
Q
V
E
--
Q
A
I
L
R
R
F
P
G
------------------------
S
D
V
--
I
I
H
Q
D
P
C
S
V
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
41.83
2%
-88
- C2 -
2JSX
-
NAPD_ECOLI
A:
[22-63]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
T
Q
L
-----
N
A
F
--
P
G
C
-
E
V
--------
A
V
S
D
A
P
S
G
Q
L
-
I
V
V
V
E
-----------
A
E
D
---
S
---
E
---
T
L
I
Q
---
T
I
E
S
V
-
R
N
V
E
G
V
L
-
A
V
S
L
---------------
V
Y
H
Q
Q
E
E
Q
G
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------