@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ZNT9_HUMAN: (2015-12-12 )
MLPGLAAAAAHRCSWSSLCRLRLRCRAAACNPSDRQEWQNLVTFGSFSNMVPCSHPYIGTLSQVKLYSTNVQKEGQGSQTLRVEKVPSFETAEGIGTELKAPLKQEPLQVRVKAVLKKREYGSKYTQNNFITGVRAINEFCLKSSDLEQLRKIRRRSPHEDTESFTVYLRSDVEAKSLEVWGSPEALAREKKLRKEAEIEYRERLFRNQKILREYRDFLGNTKPRSRTASVFFKGPGKVVMVAICINGLNCFFKFLAWIYTGSASMFSEAIHSLSDTCNQGLLALGISKSVQTPDPSHPYGFSNMRYISSLISGVGIFMMGAGLSWYHGVMGLLHPQPIESLLWAYCILAGSLVSEGATLLVAVNELRRNARAKGMSFYKYVMESRDPSTNVILLEDTAAVLGVIIAATCMGLTSITGNPLYDSLGSLGVGTLLGMVSAFLIYTNTEALLGRSIQPEQVQRLTELLENDPSVRAIHDVKATDLGLGKVRFKAEVDFDGRVVTRSYLEKQDFDQMLQEIQEVKTPEELETFMLKHGENIIDTLGAEVDRLEKELKKRNPEVRHVDLEILENTREESDIFFERENTES
Atome Classification :
(20 SA)
-------------------------------------------....---.....10....------....20........30........40........50--.........60..--......70....------------------------....80........90........100....------------...110..----.....120.......130.......----------140.......150.......160-......--.170...----....180--.......190.......200.......210-........220.......230.......240.......250--.......----..260.......270--........----------------------.280.......290.......300......--------.310----....----....320........330.....------..340--.........350..---.....360.......370.......380.---......390...---....400.......410.......420.......430.......440.......450...-------....460.......--470.......480...------....490....----...500....---------...510.......520.......530.......540----........---------------------------------.550.......560-------------.........570....-----------...580....----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------------MLP
G
---
L
A
A
A
A
A
HRC
S
W
------
S
S
L
C
R
L
R
L
R
C
RAAACN
P
S
D
R
Q
E
W
Q
N
L
V
TFGSFSNM---VPCSHPYIGT
L
S
Q
--
V
K
L
Y
STNVQKEG------------------------QGS
Q
T
L
R
V
E
KVPSFETAEGIG
T
E
LKAPLKQE------------
P
L
Q
V
R
V
K
A
----
V
L
K
K
R
EYGSKYTQNN
F
I
T
G
V
R
A
I
N
E
----------
F
CLK
S
S
D
L
E
Q
L
R
K
I
RRRSPHEDT-E
S
F
T
V
Y
--
L
RSDVEA----
K
S
L
E
VWG--
S
P
E
A
L
A
R
E
K
K
L
R
K
E
A
E
I
E
Y
R
E
R
L
F
R
N
Q
K
I
--
L
R
E
Y
R
D
F
LGNTKPRS
R
T
A
S
V
F
F
KGPG
K
V
V
M
V
A
I
C
IN
G
L
N
----
C
F
F
K
F
L
A
----
W
I
YTG
S
A
S
M
F
S
E
A
----
I
H
S
L
S
D
T
C
----------------------NQG
L
L
ALGISKSVQTPDPSHPYGF
S
N
M
R
Y
I
--------
S
S
L
-----
I
S
G
V
----
G
I
F
M
MG-A
G
L
S
W
Y
H
G
V
M
G
LLHP
Q
------
P
I
E
----
S
L
L
W
A
Y
C
I
L
A
G
S
L
V
---SEG
A
T
L
L
V
A
V
N
E
L
R
R
N
A
R
AK
G
M
S
F
Y
K
Y
V
M
---ESRDPST
N
V
I
L
L---ED
T
A
A
V
L
G
V
I
I
A
A
T
C
M
G
L
TSITG
N
P
L
Y
D
S
L
GS
L
G
V
G
T
L
L
G
M
V
S
A
F
L
IYTN
T
E
A
L
LGRSI
Q
-------
P
E
Q
V
Q
R
L
T
E
L
L
END--PS
V
R
A
I
H
D
VKATDLGL------
G
K
V
R
F
K
A
E
VDF----DGR
V
V
T
R
S
Y
L
---------
E
K
Q
D
F
D
Q
M
L
Q
E
I
Q
EVK
T
P
E
E
L
E
T
F
M
L
KHG
E
N
I
I
D
------
T
LG
A
E
V
D
R
---------------------------------
L
E
K
E
L
K
KRNPE
V
---------------
R
H
V
D
L
E
I
L
E
NTREES
D
-----------
I
F
F
ERENTES----
36
Fugue
74.43
21%
-38
- C1 -
4OPU
3
?
A:
[2-453]
-----------------------------------M
K
E
L
K
Y
D
V
L
I
I
G
GG
F
A
G
S
S
A
A
Y
Q
L
S
R
------
R
G
L
-
K
I
L
L
V
D
S
K
P
W
N
R
I
G
D
K
P
C
G
-
D
A
V
S
K
A
H
F
D
K
L
GMP
Y
P
K
G
E
E
L
E
N
K
I
N
G
--
I
K
L
Y
S
P
D
M
Q
---------------------------------------
T
V
W
T
V
N
H
E
G
F
E
L
N
A
P
L
Y
N
Q
------------
R
V
L
K
E
A
Q
D
R
G
V
E
I
W
D
L
T
T
A
M
K
P
I
F
E
D
G
Y
V
K
G
A
V
L
F
N
------------------------------
R
R
T
N
-
E
E
L
T
V
Y
--
S
K
V
V
V
E
A
TGYS
R
S
F
R
S
K
L
--
P
P
E
L
P
I
T
E
D
L
D
D
K
D
A
D
V
A
Y
R
E
V
L
L
T
K
E
D
I
E
D
H
D
Y
L
R
I
F
I
D
Q
E
T
S
P
G
G
Y
W
W
Y
F
P
K
G
K
N
-
K
V
N
V
G
L
G
I
Q
G
G
M
----
G
------------
Y
P
S
I
H
E
Y
Y
K
K
Y
----
L
D
K
Y
A
P
D
V
----------------------
D
K
S
K
L
L
V
K
G
G
A
L
V
P
T
R
R
P
L
Y
T
M
A
W
N
G
I
I
V
I
--------
G
D
S
-----
G
F
T
V
NPVH
G
G
G
K
G
S
-
A
M
I
S
G
Y
C
A
A
K
A
I
L
S
A
F
------
E
T
G
DFSA
S
G
L
W
D
M
N
I
C
Y
---
V
---
N
E
Y
G
A
K
Q
A
S
L
D
I
F
R
R
F
L
Q
K
L
S
N
D
D
I
N
Y
G
M
---
K
K
K
I
I
K
E
E
D
L
L
E
---
A
S
E
K
G
D
L
H
L
S
V
A
D
K
A
M
R
V
I
S
G
L
G
R
P
--------------------------
S
L
L
F
K
L
K
A
V
-------
A
E
S
M
K
K
I
K
E
L
Y
L
N
Y
--
P
R
----------------------------------------------------------------------------------
S
P
S
S
L
G
------
S
W
R
R
E
V
D
N
---------------------------------
V
L
T
E
F
N
K
S
L
S
----------------------------------------------------------
33
Fugue
70.57
19%
-38
- C2 -
4CR2
-
RPN1_YEAST
Z:
[49-993]
LELL
V
E
R
L
K
E
DDS
S
L
Y
E
A
S
L
N
A
L
K
E
S
I
KNSTSSMTAVPK
P
L
K
F
L
R
P
T
---
Y
P
D
L
C
S
I
Y
D
K
W
TDPN
L
K
S
S
L
A
D
V
-
L
S
I
L
A
M
T
Y
S
E
N
G
K
H
D
S
L
R
Y
R
L
L
S
D
V
S
D
F
---
E
G
W
G
H
E
Y
I
R
H
L
A
L
E
I
G
E
V
Y
N
D
Q
V
E
K
D
A
E
D
ETSSDGSKSDGSAATSGFEFSK
E
D
T
L
R
L
C
L
D
I
V
P
Y
F
L
K
H
N
G
E
E
D
A
V
D
L
L
L
E
I
E
S
I
D
K
L
P
Q
F
V
DEN
T
F
Q
R
V
C
Q
Y
----
M
V
A
C
V
P
L
L
P
P
P
E
D
V
A
F
L
K
T
A
Y
S
I
Y
L
S
Q
NE
L
T
D
A
I
A
L
A
V
R
L
G
E
E
D
M
I
R
S
V
F
D
A
T
S
D
P
V
M
-
H
K
Q
L
A
Y
--
I
L
A
A
-
Q
K
----
T
S
F
E
Y
E
G
--
V
Q
D
I
I
G
N
G
K
L
S
E
H
F
L
Y
L
A
K
E
L
N
L
T
G
P
K
V
P
--
E
D
I
Y
K
S
H
L
D
N
S
K
S
V
F
S
S
A
G
---
L
D
S
A
Q
Q
N
L
A
S
S
F
V
N
G
F
L
N
LGY
C
N
D
K
L
I
V
D
N
D
N
W
V
Y
K
T
K
G
D
G
M
T
S
A
----
V
A
S
I
G
S
I
Y
QWN
L
D
G
L
Q
Q
L
D
K
Y
L
Y
VDE
P
E
V
K
A
G
A
L
L
G
I
G
I
S
A
S
G
V
H
D
G
E
V
E
P
A
L
L
L
L
Q
D
Y
V
T
NPD
T
K
I
S
S
A
A
-----
I
L
G
L
----
G
I
A
F
A
G
-
S
K
---
N
D
E
V
L
G
L
L
L
P
I
AASTDL
P
I
E
----
T
A
A
M
A
S
L
A
L
A
H
V
F
V
GTC
N
G
D
I
T
T
S
I
M
D
N
F
L
E
R
T
A
I
E
L
K
T
D
W
V
R
F
L
-------
A
L
A
L
G
I
L
Y
M
GQG
E
Q
V
D
D
V
L
E
T
I
S
A
I
E
H
P
M
T
S
A
I
--
E
V
L
V
G
S
C
A
Y
T
G
T
G
D
V
L
L
I
Q
D
L
L
H
R
L
T
L
A
Y
A
V
L
G
I
A
L
I
A
L
GE
D
I
G
K
E
M
S
L
R
H
F
G
H
L
M
H
Y
--
G
N
-
E
H
I
R
R
M
V
P
L
A
M
G
I
V
S
VSDP
Q
M
K
V
F
D
T
L
T
R
F
S
H
DA
D
L
E
V
S
M
N
S
I
F
A
M
G
L
C
G
AGT
N
N
A
R
L
A
Q
L
L
R
Q
L
A
S
Y
Y
S
R
E
Q
D
A
L
F
I
T
R
L
A
Q
G
L
L
H
LGKGTM
T
M
D
V
F
N
D
A
HVLN
K
V
T
L
A
S
I
L
T
T
A
V
GLVSPSFMLKHHQLFYM
L
N
A
G
I
R
P
K
F
I
L
A
L
NDEG
E
P
I
K
V
N
V
R
V
G
Q
P
V
L
L
N
H
G
E
R
A
E
L
E
T
D
EYISYTSHIEG
V
V
I
L
K
K
N
P
D
Y
REEE
21
HHSearch
66.55
22%
-55
- C3 -
3J1Z
-
?
P:
[9-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
W
V
K
L
A
S
R
A
S
V
A
T
A
L
T
L
----
I
T
I
K
L
L
A
----
W
L
Y
S
G
S
A
S
M
L
A
S
L
----
T
D
S
F
A
D
T
L
----------------------
A
S
I
I
N
F
I
A
I
R
Y
A
I
V
P
A
D
H
D
H
R
Y
G
H
G
K
A
E
P
L
--------
A
A
L
-----
A
Q
S
A
----
F
I
M
G
S
A
-
F
L
L
-
L
F
Y
G
G
E
R
L
L
N
P
S
------
P
V
E
----
N
A
T
L
G
V
V
V
S
V
V
A
I
V
---
L
---
T
L
A
L
V
L
L
Q
K
R
A
L
A
A
T
N
S
T
V
V
E
A
------
D
------
S
L
H
Y
K
---
S
D
L
F
L
N
A
A
V
L
L
A
L
V
L
S
Q
----
Y
G
W
W
W
A
D
G
L
F
A
V
L
I
A
C
Y
I
G
Q
Q
A
F
D
L
G
Y
R
S
I
Q
A
L
L
D
R
E
L
D
-------
E
D
T
R
Q
R
I
K
L
I
A
K
E
D
--
P
R
V
L
G
L
H
D
L
R
T
R
Q
A
G
K
------
T
-
V
F
I
Q
F
H
L
E
L
----
D
G
N
L
-------------------------------
S
--------
L
N
E
A
H
S
I
-------------
T
D
T
---------------------------------
T
G
L
R
V
K
A
A
F
E
D
----------------
A
E
V
I
I
H
Q
D
P
V
Q
V
E
P
T
T
-----------
Q
-------------
22
HHSearch
63.36
19%
-47
- C3 -
3H90
-
FIEF_ECOLI
A:
[2-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
R
A
A
I
A
A
T
A
M
A
S
L
L
----
L
L
I
K
I
F
A
----
W
W
Y
T
G
S
V
S
I
L
A
A
L
----
V
D
S
L
V
D
I
G
----------------------
A
S
L
T
N
L
L
V
V
R
Y
S
L
Q
P
A
D
D
N
H
S
F
G
H
G
K
A
E
S
L
--------
A
A
L
-----
A
Q
S
M
----
F
I
S
G
S
A
-
L
F
L
-
F
L
T
G
I
Q
H
L
I
S
P
T
------
P
M
T
----
D
P
G
V
G
V
I
V
T
I
V
A
L
I
---
C
---
T
I
I
L
V
S
F
Q
R
W
V
V
R
R
T
Q
S
Q
A
V
R
A
------
D
------
M
L
H
Y
Q
---
S
D
V
M
M
N
G
A
I
L
L
A
L
G
L
S
W
----
Y
G
W
H
R
A
D
A
L
F
A
L
G
I
G
I
Y
I
L
Y
S
A
L
R
M
G
Y
E
A
V
Q
S
L
L
D
R
A
L
P
-------
D
E
E
R
Q
E
I
I
D
I
V
T
S
W
--
P
G
V
S
G
A
H
D
L
R
T
R
Q
S
G
P
------
T
R
-
F
I
Q
I
H
L
E
M
----
E
D
S
L
---
P
------------------------------------
L
V
Q
A
H
M
V
-------------
A
D
Q
---------------------------------
V
E
Q
A
I
L
R
R
F
P
G
----------------
S
D
V
I
I
H
Q
D
P
C
S
V
V
----------------------------
23
HHSearch
61.47
99%
-18
- C3 -
2ENK
-
A:
[7-101]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
Y
T
Q
N
N
F
I
T
G
V
R
A
I
N
E
----------
F
C
L
K
S
S
D
L
E
Q
L
R
K
I
R
R
R
S
P
H
E
D
T
-
E
S
F
T
V
Y
--
L
R
S
D
V
E
A
----
K
S
L
E
V
W
G
--
S
P
E
A
L
A
R
E
K
K
L
R
K
E
A
E
I
E
Y
R
E
R
L
F
R
N
Q
K
I
--
L
R
E
Y
R
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
61.21
100%
-18
- C3 -
2ENK
-
A:
[8-101]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
T
Q
N
N
F
I
T
G
V
R
A
I
N
E
----------
F
C
L
K
S
S
D
L
E
Q
L
R
K
I
R
R
R
S
P
H
E
D
T
-
E
S
F
T
V
Y
--
L
R
S
D
V
E
A
----
K
S
L
E
V
W
G
--
S
P
E
A
L
A
R
E
K
K
L
R
K
E
A
E
I
E
Y
R
E
R
L
F
R
N
Q
K
I
--
L
R
E
Y
R
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
60.49
25%
-47
- C3 -
3J1Z
-
?
P:
[29-257]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
L
A
----
W
L
Y
S
G
S
A
S
M
L
A
S
L
----
T
D
S
F
A
D
T
L
----------------------
A
S
I
I
N
F
I
A
I
R
Y
A
I
V
P
A
D
H
D
H
R
Y
G
H
G
K
A
E
P
L
--------
A
A
L
-----
A
Q
S
A
------
F
I
M
G
S
A
F
L
L
L
F
Y
G
G
E
R
L
L
N
P
S
------
P
V
E
----
N
-----
A
T
L
G
V
V
V
S
---
V
V
A
I
V
L
T
L
A
L
V
L
L
Q
K
R
A
L
A
A
T
N
S
---
T
V
V
---
E
A
D
S
L
H
Y
K
S
D
L
F
---
L
N
A
A
V
L
L
A
L
V
L
--------
S
Q
Y
G
W
W
W
A
D
G
L
F
A
V
L
I
A
C
Y
I
G
Q
Q
A
F
D
L
G
Y
R
S
I
Q
A
L
L
D
R
E
L
D
-------
E
D
T
R
Q
R
I
K
L
I
A
K
E
D
--
P
R
V
L
G
L
H
D
L
R
T
R
Q
A
G
-------
K
T
V
F
I
Q
F
H
L
E
L
----
D
G
N
L
S
L
N
E
A
H
---------
S
I
T
D
T
T
G
L
R
V
K
A
A
F
E
D
A
E
V
I
I
H
Q
D
P
V
Q
V
E
P
T
T
Q
--------------------------------------------------------------------------------------------------------------------
31
Fugue
54.27
18%
-32
- C3 -
2QFI
-
FIEF_ECOLI
A:
[5-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
R
L
V
S
R
A
A
I
A
A
T
A
M
A
S
L
L
----
L
L
I
K
I
F
A
----
W
W
Y
T
G
S
V
S
I
L
A
A
L
----
V
D
S
L
V
D
I
G
----------------------
A
S
L
T
N
L
L
V
V
R
Y
S
L
Q
P
A
D
D
N
H
S
F
G
H
G
K
A
E
S
L
--------
A
A
L
-----
A
Q
S
M
----
F
I
S
G
S
A
-
L
F
L
F
-
L
T
G
I
Q
H
L
I
S
P
T
------
P
M
T
----
D
-------------------
P
G
V
G
V
I
V
T
I
V
A
L
I
C
T
I
I
L
V
S
F
Q
R
W
V
V
---
R
R
T
Q
S
Q
A
V
R
A
D
M
---
L
H
Y
Q
S
D
V
M
M
N
G
A
I
L
L
A
L
G
L
S
W
Y
G
W
H
R
A
D
A
L
F
A
L
G
I
G
I
Y
I
L
Y
S
A
L
R
M
G
Y
E
A
V
Q
S
L
L
D
R
A
L
P
-------
D
E
E
R
Q
E
I
I
D
I
V
T
S
W
--
P
G
V
S
G
A
H
D
L
R
T
R
Q
S
G
-------------
P
T
R
F
I
----
Q
I
H
L
E
M
E
D
S
L
---------
P
L
V
Q
A
H
M
V
A
D
Q
V
E
Q
A
I
L
R
R
F
P
G
S
D
V
I
I
H
Q
D
P
C
S
V
------
V
------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
51.89
23%
-55
- C3 -
3H90
-
FIEF_ECOLI
A:
[15-228]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
----
L
L
I
K
I
F
A
----
W
W
Y
T
G
S
V
S
I
L
A
A
L
----
V
D
S
L
V
D
I
G
----------------------
A
S
L
T
N
L
L
V
V
R
Y
S
L
Q
P
A
D
D
N
H
S
F
G
H
G
K
A
E
S
L
--------
A
A
L
A
Q
S
M
F
I
S
G
S
----
A
L
F
L
F
-------
L
T
G
I
Q
H
L
I
S
P
T
------
P
------------------
M
T
---
D
P
G
V
G
V
I
V
T
I
V
A
L
--
I
C
T
I
I
L
V
S
F
Q
R
W
V
V
R
R
T
Q
S
Q
A
V
R
A
D
M
L
H
Y
---
Q
S
D
V
M
M
N
G
A
I
L
L
A
--
L
G
L
-
S
W
Y
G
W
H
R
A
D
A
L
F
A
L
G
I
G
I
Y
I
L
Y
S
A
L
R
M
G
Y
E
A
V
Q
S
L
L
D
R
A
L
P
-------
D
E
E
R
Q
E
I
I
D
I
V
T
S
W
--
P
G
V
S
G
A
H
D
L
R
T
R
Q
S
G
P
------
T
R
F
I
Q
I
H
L
E
M
E
----
D
S
L
P
L
V
Q
A
H
M
---------
V
A
D
Q
V
E
Q
A
I
L
R
R
F
P
G
S
D
V
I
I
H
Q
D
P
C
S
V
V
-------------------------------------------------------------------------------------------------------------------------
27
HHSearch
48.87
18%
-20
- C3 -
3BYP
-
?
A:
[6-87]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
P
-------
P
E
E
V
E
R
I
R
A
F
L
Q
E
R
I
R
G
R
A
L
E
V
H
D
L
K
T
R
R
A
G
P
------
R
-
S
F
L
E
F
H
L
V
V
----
R
G
D
T
-------------------------------
P
--------
V
E
E
A
H
R
L
-------------
C
D
E
---------------------------------
L
E
R
A
L
A
Q
A
F
P
G
L
----------------
Q
A
T
I
H
V
E
P
E
G
------------------------------
26
HHSearch
48.84
18%
-12
- C3 -
2ZZT
-
?
A:
[4-87]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
R
T
E
-----
L
D
M
Y
D
D
I
F
A
V
L
E
R
F
--
P
N
V
H
N
P
H
R
V
R
I
R
R
V
G
T
--------
Y
F
I
E
M
D
I
E
V
----
D
G
K
M
-------------------------------
S
--------
V
K
D
A
H
E
L
-------------
T
V
K
---------------------------------
I
R
K
E
M
L
K
R
R
D
D
I
---------------
E
D
V
T
I
H
V
E
P
L
G
N
-----------------------------
3
PsiBlast_PDB
47.94
23%
-45
- C3 -
2QFI
-
FIEF_ECOLI
A:
[22-240]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
----
L
L
I
K
I
F
A
----
W
W
Y
T
G
S
V
S
I
L
A
A
L
----
V
D
S
L
V
D
I
G
----------------------
A
S
L
T
N
L
L
V
V
R
Y
S
L
Q
P
A
D
D
N
H
S
F
G
H
G
K
A
E
S
L
--------
A
A
L
A
Q
S
MF
I
S
G
S
----
A
L
F
L
-------
F
L
T
G
I
Q
H
L
I
S
P
T
------
P
------------------
M
T
---
D
P
G
V
G
V
I
V
T
I
V
A
L
--
I
C
T
I
I
L
V
S
F
Q
R
W
V
V
RRT
Q
S
Q
A
V
R
A
D
M
L
H
Y
---
Q
S
D
V
M
M
N
G
A
I
L
L
A
--
L
G
L
-
S
W
Y
G
W
H
R
A
D
A
L
F
A
L
G
I
G
I
Y
I
L
Y
S
A
L
R
M
G
Y
E
A
V
Q
S
L
L
D
R
A
L
P
-------
D
E
E
R
Q
E
I
I
D
I
V
T
S
W
--
P
G
V
S
G
A
H
D
L
R
T
R
Q
S
G
P
------
T
R
F
I
Q
I
H
L
E
M
E
----
D
S
L
P
L
V
Q
A
H
M
---------
V
A
D
Q
V
E
Q
A
I
L
R
R
F
P
G
S
D
V
I
I
H
Q
D
P
C
S
V
V
-------------------------------------------------------------------------------------------------------------------------
25
HHSearch
44.73
14%
-14
- C3 -
3W61
-
?
A:
[3-82]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
-------
E
A
V
Q
N
R
I
V
E
A
A
E
R
V
--
P
G
V
R
G
V
I
H
L
R
A
R
Y
V
G
Q
------
D
-
I
W
A
D
M
I
I
G
V
----
D
P
E
N
-------------------------------
T
--------
V
E
Q
A
H
E
I
-------------
C
E
A
---------------------------------
V
Q
A
A
V
C
G
K
I
R
R
I
---------------
E
S
L
A
V
S
A
E
A
R
E
------------------------------
10
PsiBlast_PDB
41.24
21%
-53
- C3 -
1NY5
2
?
A:
[60-272]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
I
L
K
W
I
K
E
R
S
P
E
T
E
V
-
I
V
I
T
G
H
GT
I
K
T
A
V
E
A
----
M
K
M
G
A
Y
D
F
L
T
K
P
C
M
L
E
E
I
E
L
T
I
N
K
A
I
E
H
R
-
K
L
R
K
E
N
E
L
--
L
R
R
E
K
D
L
--------
K
E
E
E
Y
V
F
E
S
P
-
K
M
K
E
I
L
E
K
I
K
K
I
S
----
C
--
A
E
C
P
----
V
L
I
T
G
E
S
G
V
G
K
E
V
V
A
R
L
I
H
K
L
S
D
R
S
----------------------
K
E
P
F
V
A
L
N
V
A
S
I
P
R
D
I
F
E
A
E
L
F
G
Y
E
K
G
A
F
T
--------
G
A
V
-----
S
S
K
E
----
G
F
F
E
L
A
-
D
G
G
T
L
F
L
D
E
I
G
E
L
S
L
E
------
A
Q
A
----
K
L
L
--
R
V
I
E
S
G
K
F
Y
---
R
L
G
G
R
K
E
I
E
V
N
V
R
I
L
A
A
T
N
R
N
I
K
E
L
V
K
E
G
---
K
F
R
E
D
L
Y
Y
R
L
G
V
---
I
E
I
E
I
P
P
L
R
E
R
K
E
D
I
I
P
L
A
N
H
F
L
K
K
F
S
R
K
Y
A
K
E
V
E
G
F
T
K
S
A
Q
E
L
L
L
S
Y
P
W
Y
G
N
V
R
E
L
K
N
V
-------
I
E
R
A
V
L
F
S
E
G
K
F
I
D
--
R
G
E
L
S
C
L
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
33.58
27%
119
- C3 -
5A3D
2
RAD14_YEAST
A:
[57-114]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
D
E
D
L
F
H
R
L
E
K
P
N
P
H
S
G
T
F
A
R
M
Q
L
F
--
V
R
C
E
V
E
A
----
F
A
F
K
K
W
G
--
G
E
E
G
L
D
E
E
W
Q
R
R
E
E
G
K
A
H
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
32.96
27%
111
- C3 -
5A39
-
RAD14_YEAST
A:
[57-114]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
D
E
D
L
F
H
R
L
E
K
P
N
P
H
S
G
T
F
A
R
M
Q
L
F
--
V
R
C
E
V
E
A
----
F
A
F
K
K
W
G
--
G
E
E
G
L
D
E
E
W
Q
R
R
E
E
G
K
A
H
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
30.64
23%
-26
- C3 -
3H90
-
FIEF_ECOLI
A:
[115-201]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
A
L
I
C
T
I
I
L
----
V
S
F
Q
R
W
V
----
V
R
R
T
Q
S
Q
A
V
R
A
D
M
----
L
H
Y
Q
S
D
V
M
----------------------
M
N
G
A
I
L
L
A
L
G
L
S
W
--------
Y
G
W
H
R
A
D
A
L
--------
F
A
L
-----
G
I
G
I
----
Y
I
L
Y
S
A
-
L
R
M
-
G
Y
E
A
V
Q
S
L
L
D
R
A
------
L
P
D
----
E
E
R
Q
E
I
I
D
I
V
T
S
W
P
---
G
V
S
G
A
H
D
L
R
T
R
Q
S
G
P
T
R
F
I
Q
I
H
L
E
M
E
D
S
L
---
P
L
V
Q
A
H
M
V
A
D
Q
V
---
E
Q
A
I
L
R
R
F
P
G
S
D
V
I
I
H
Q
D
P
C
S
V
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
27.60
21%
-9
* C3 *
3J1Z
-
?
P:
[124-210]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
A
I
V
L
T
L
A
L
----
V
L
L
Q
K
R
A
----
L
A
A
T
N
S
T
V
V
E
A
D
S
----
L
H
Y
K
S
D
L
F
----------------------
L
N
A
A
V
L
L
A
L
V
L
S
Q
--------
Y
G
W
W
W
A
D
G
L
--------
F
A
V
-----
L
I
A
C
----
Y
I
G
Q
Q
A
-
F
D
L
-
G
Y
R
S
I
Q
A
L
L
D
R
E
------
L
D
E
----
D
T
R
Q
R
I
K
L
I
A
K
E
D
P
---
R
V
L
G
L
H
D
L
R
T
R
Q
A
G
K
T
V
F
I
Q
F
H
L
E
L
D
G
N
L
---
S
L
N
E
A
H
S
I
T
D
T
T
---
G
L
R
V
K
A
A
F
E
D
A
E
V
I
I
H
Q
D
P
V
Q
V
E
P
T
T
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
24.98
42%
336
- C3 -
3UZS
-
ARBK1_BOVIN
A:
[522-549]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
T
V
F
D
------
T
I
N
A
E
T
D
R
---------------------------------
L
E
A
R
K
K
T
K
N
K
Q
L
---------------
G
H
---------------------------------------
17
PsiBlast_PDB
24.89
42%
346
- C3 -
3PVW
-
ARBK1_BOVIN
A:
[522-549]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
T
V
F
D
------
T
I
N
A
E
T
D
R
---------------------------------
L
E
A
R
K
K
T
K
N
K
Q
L
---------------
G
H
---------------------------------------