@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Screening
Virtual Screening Score
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : AAPK1_HUMAN: (2020-09-03 )
MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPGSHTIEFFEMCANLIKILAQ
Atome Classification :
(443 SA)
.........10........20........30........40........50........----60........70-........80.........90........100.......110.......120.......130.......140.......150.....---.-----.---160--..---.---.--....170-..----.---...---.180.......190.......200-----.--..-------....210.......220.......230--...-..--..240.--.-....----.----..--250----.--...--.....260....-----.-----.-----.270.......280---..--------------.......----290.......--300.......310.......320.......330.......340.......350.......360..---...-----..370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(pKd)
(pKd)
(Uniprot)
MR
R
L
S
S
W
R
K
M
A
T
A
E
KQKHDG
R
V
K
I
G
H
Y
I
LGDTLGVG
T
F
G
K
V
K
VGKHELTG
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
R
R
E
I
Q
N
L
K
-
L
FRHP
H
I
I
K
L
Y
Q
V
IST
P
S
D
I
F
M
V
M
E
Y
VSG
G
E
L
F
D
Y
I
C
KNGRLD
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
HRDLKPE
N
V
L
---
L
-----D---AH---MN---A---
K
--
I
A
D
F
G
L
S
-
N
M----M---SDG---
E
F
L
R
TSCGSPNYAA
P
E
VISGRLYA-----G--PE-------VDIWSS
G
V
I
L
Y
A
L
L
CGTLPFDDD
H
V
P
T
--
L
F
K
-
K
I
--CDG--I--F-YTPQ----Y----L
N
--
P
------
S
--
V
I
S
--
L
L
K
H
M
L
QVDPM
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
D
--------------
L
P
K
YLFP----EDPSYSSTMI--
D
D
E
A
L
K
E
V
C
E
KFEC
S
E
E
E
V
L
S
C
L
YNRNHQ
D
P
L
A
V
A
Y
H
L
I
ID
N
R
R
I
M
NEAK
D
F
Y
L
ATSP
P
D
S
FLDD---HHL-----TRPHPERV
P
F
L
V
AETPRARH
T
L
D
ELNP
Q
K
S
K
H
QGV
R
K
A
K
W
H
LGIRSQSR
P
N
D
I
M
A
E
V
C
R
A
I
K
QLDY
E
W
K
VVN
P
Y
Y
L
R
V
RRKNPVTSTY
S
K
M
S
L
Q
L
Y
Q
VDS
R
T
Y
L
L
D
FRSI
D
D
E
I
TEAKSGTATPQRSGSVS
N
Y
R
S
CQRSDSDAEAQGKSS
E
V
S
L
T
S
SVTSLDSSPVDLTPRPGS
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
LAQ
2
PsiBlast_PDB
91.34
98%
-119
- C5 -
-
4RER
9.1
-
AAPK1_HUMAN
A:
[1-540]
-------------------
G
S
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
R
R
E
I
Q
N
L
K
-
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
---
K
--
I
A
D
F
G
L
S
-
N
M
----
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
--
L
F
K
-
K
I
--
C
D
G
--
I
--
F
-
Y
T
P
Q
----
Y
----
L
N
--
P
------
S
--
V
I
S
--
L
L
K
H
M
L
Q
V
D
P
M
K
-----
R
-----
A
-----
S
I
K
D
I
R
E
H
E
W
F
K
-----
Q
D
--------------
L
P
K
Y
L
F
P
----
E
D
P
S
Y
S
------
D
D
E
A
L
K
E
V
C
E
K
F
E
C
S
E
E
E
V
L
S
C
L
Y
N
R
N
H
Q
D
P
L
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
F
Y
L
A
T
S
P
P
----
D
D
---
H
H
L
-----
T
R
P
H
P
E
R
V
P
F
L
V
A
E
T
P
-------------------
R
K
A
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
Y
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
G
I
------------------------------------------------------
T
P
R
P
G
S
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
Q
570
HHSearch
91.02
96%
-119
- C5 -
-
4RER
9.1
-
AAPK1_HUMAN
A:
[2-540]
--------------------
S
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
R
R
E
I
Q
N
L
K
-
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
---
K
--
I
A
D
F
G
L
S
-
N
M
----
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
--
L
F
K
-
K
I
--
C
D
G
--
I
--
F
-
Y
T
P
Q
----
Y
----
L
N
--
P
------
S
--
V
I
S
--
L
L
K
H
M
L
Q
V
D
P
M
K
-----
R
-----
A
-----
S
I
K
D
I
R
E
H
E
W
F
K
-----
Q
D
--------------
L
P
K
Y
L
F
P
----
E
D
P
S
Y
S
------
D
D
E
A
L
K
E
V
C
E
K
F
E
C
S
E
E
E
V
L
S
C
L
Y
N
R
N
H
Q
D
P
L
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
F
Y
L
A
T
S
P
P
----
D
D
---
H
H
L
-----
T
R
P
H
P
E
R
V
P
F
L
V
A
E
T
P
-------------------
R
K
A
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
Y
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
G
I
------------------------------------------------------
T
P
R
P
G
S
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
Q
18
PsiBlast_PDB
88.59
75%
-134
- C5 -
-
5ISO
-
-
?
A:
[9-551]
-------------------
G
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
K
R
E
I
Q
N
L
K
-
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
---
K
--
I
A
D
F
G
L
S
-
N
M
----
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
T
--
L
F
K
-
K
I
--
R
G
G
--
V
--
F
-
Y
I
P
E
----
Y
----
L
N
--
R
------
S
--
V
A
T
--
L
L
M
H
M
L
Q
V
D
P
L
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
D
--------------
L
P
S
Y
L
F
P
----
E
D
P
S
Y
D
A
N
V
I
--
D
D
E
A
V
K
E
V
C
E
K
F
E
C
T
E
S
E
V
M
N
S
L
Y
S
G
D
P
Q
D
Q
L
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
Q
A
S
E
F
Y
L
A
S
S
P
------------------
L
K
P
H
P
E
R
M
P
P
L
I
A
D
S
-------------------
V
K
K
A
K
W
H
L
G
I
R
S
Q
S
K
P
Y
D
I
M
A
E
V
Y
R
A
M
K
Q
L
D
F
E
W
K
V
V
N
A
Y
H
L
R
V
R
R
K
N
P
V
T
G
N
Y
V
K
M
S
L
Q
L
Y
L
V
D
N
R
S
Y
L
L
D
F
K
S
I
D
D
---------------------------------------------------------
P
R
L
G
S
H
T
M
D
F
F
E
M
C
A
S
L
I
T
T
L
A
-
575
HHSearch
88.39
99%
-114
- C5 -
-
6C9H
8.9
-
AAPK1_HUMAN
A:
[9-493]
-------------------
G
S
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
R
R
E
I
Q
N
L
K
-
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
---
K
--
I
A
D
F
G
L
S
-
N
M
----
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
--
L
F
K
-
K
I
--
C
D
G
--
I
--
F
-
Y
T
P
Q
----
Y
----
L
N
--
P
------
S
--
V
I
S
--
L
L
K
H
M
L
Q
V
D
P
M
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
D
--------------
L
P
K
Y
L
F
P
----
E
D
P
S
Y
S
S
T
M
I
--
D
D
E
A
L
K
E
V
--------------
L
Y
N
R
N
H
Q
D
P
L
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
F
Y
L
A
T
S
P
------------------
T
R
P
H
P
E
R
V
P
F
--------------------------
K
A
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
Y
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
E
L
T
P
------------------------------------------------------
R
P
G
S
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
-
17
PsiBlast_PDB
88.10
80%
-136
- C5 -
-
5EZV
-
-
AAPK1_HUMAN (first)
A:
[22-559]
------------------
D
G
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
K
R
E
I
Q
N
L
K
-
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
---
K
--
I
A
D
F
G
L
S
-
N
M
----
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
T
--
L
F
K
-
K
I
--
R
G
G
--
V
--
F
-
Y
I
P
E
----
Y
----
L
N
--
R
------
S
--
V
A
T
--
L
L
M
H
M
L
Q
V
D
P
L
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
D
--------------
L
P
S
Y
L
F
P
----
E
D
P
S
Y
D
A
N
V
I
--
D
D
E
A
V
K
E
V
C
E
K
F
E
C
T
E
S
E
V
M
N
S
L
Y
S
G
D
P
Q
D
Q
L
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
Q
A
S
E
F
Y
L
A
S
---------------------
R
P
H
P
E
R
V
P
F
--------------------------
K
A
K
W
H
L
G
I
R
S
Q
S
K
P
Y
D
I
M
A
E
V
Y
R
A
M
K
Q
L
D
F
E
W
K
V
V
N
A
Y
H
L
R
V
R
R
K
N
P
V
T
G
N
Y
V
K
M
S
L
Q
L
Y
L
V
D
N
R
S
Y
L
L
D
F
K
S
I
D
D
-----------------------------------------------------------
L
G
S
H
T
M
D
F
F
E
M
C
A
S
L
I
T
T
L
A
-
26
Blastp_CBE
87.63
76%
-96
- C5 -
-
6B1U
-
-
AAPK2_HUMAN
C:
[22-565]
-------------------
G
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
K
R
E
I
Q
N
L
K
-
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
---
K
--
I
A
D
F
G
L
S
-
N
M
----
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
T
--
L
F
K
-
K
I
--
R
G
G
--
V
--
F
-
Y
I
P
E
----
Y
----
L
N
--
R
------
S
--
V
A
T
--
L
L
M
H
M
L
Q
V
D
P
L
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
G
--------------
L
P
S
Y
L
F
P
----
E
D
P
S
Y
D
A
N
V
I
--
D
D
E
A
V
K
E
V
C
E
K
F
E
C
T
E
S
E
V
M
N
S
L
Y
S
G
D
P
Q
D
Q
L
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
Q
A
S
E
F
Y
L
A
S
S
P
------------
M
HIPPG
L
K
P
H
P
E
R
M
P
P
L
I
A
D
-------------------
A
V
K
K
A
K
W
H
L
G
I
R
S
Q
S
K
P
Y
D
I
M
A
E
V
Y
R
A
M
K
Q
L
D
F
E
W
K
V
V
N
A
Y
H
L
R
V
R
R
K
N
P
V
T
G
N
Y
V
K
M
S
L
Q
L
Y
L
V
D
N
R
S
Y
L
L
D
F
K
S
I
D
D
---------------------------------------------------------
P
R
L
G
S
H
T
M
D
F
F
E
M
C
A
S
L
I
T
T
L
A
R
27
Blastp_CBE
87.62
76%
-132
- C5 -
-
6B1U
-
-
AAPK2_HUMAN
A:
[21-563]
------------------
D
G
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
K
R
E
I
Q
N
L
K
-
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
---
K
--
I
A
D
F
G
L
S
-
N
M
----
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
T
--
L
F
K
-
K
I
--
R
G
G
--
V
--
F
-
Y
I
P
E
----
Y
----
L
N
--
R
------
S
--
V
A
T
--
L
L
M
H
M
L
Q
V
D
P
L
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
G
--------------
L
P
S
Y
L
F
P
----
E
D
P
S
Y
D
A
N
V
I
--
D
D
E
A
V
K
E
V
C
E
K
F
---
E
S
E
V
M
N
S
L
Y
----
Q
D
Q
L
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
Q
A
S
E
F
Y
L
A
S
S
P
------------------
L
K
P
H
P
E
R
M
P
P
L
I
-----------------------
K
K
A
K
W
H
L
G
I
R
S
Q
S
K
P
Y
D
I
M
A
E
V
Y
R
A
M
K
Q
L
D
F
E
W
K
V
V
N
A
Y
H
L
R
V
R
R
K
N
P
V
T
G
N
Y
V
K
M
S
L
Q
L
Y
L
V
D
N
R
S
Y
L
L
D
F
K
S
I
D
D
---------------------------------------------------------
P
R
L
G
S
H
T
M
D
F
F
E
M
C
A
S
L
I
T
T
L
--
572
HHSearch
87.10
75%
-94
- C5 -
-
6B1U
-
-
AAPK2_HUMAN
C:
[22-565]
-------------------
G
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
K
R
E
I
Q
N
L
K
-
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
---
K
--
I
A
D
F
G
L
S
-
N
M
----
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
T
--
L
F
K
-
K
I
--
R
G
G
--
V
--
F
-
Y
I
P
E
----
Y
----
L
N
--
R
------
S
--
V
A
T
--
L
L
M
H
M
L
Q
V
D
P
L
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
G
--------------
L
P
S
Y
L
F
P
----
E
D
P
S
Y
D
A
N
V
I
--
D
D
E
A
V
K
E
V
C
E
K
F
E
C
T
E
S
E
V
M
N
S
L
Y
S
G
D
P
Q
D
Q
L
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
Q
A
S
E
F
Y
L
A
S
S
P
-------MHI
P
P
G
-----
L
K
P
H
P
E
R
M
P
P
L
I
A
D
-------------------
A
V
K
K
A
K
W
H
L
G
I
R
S
Q
S
K
P
Y
D
I
M
A
E
V
Y
R
A
M
K
Q
L
D
F
E
W
K
V
V
N
A
Y
H
L
R
V
R
R
K
N
P
V
T
G
N
Y
V
K
M
S
L
Q
L
Y
L
V
D
N
R
S
Y
L
L
D
F
K
S
I
D
D
---------------------------------------------------------
P
R
L
G
S
H
T
M
D
F
F
E
M
C
A
S
L
I
T
T
L
A
R
21
Blastp_CBE
86.31
81%
-122
- C5 -
-
5EZV
-
-
AAPK1_HUMAN (first)
C:
[23-559]
-------------------
G
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
K
R
E
I
Q
N
L
K
-
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
---
K
--
I
A
D
F
G
L
S
-
N
M
----
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
T
--
L
F
K
-
K
I
--
R
G
G
--
V
--
F
-
Y
I
P
E
----
Y
----
L
N
--
R
------
S
--
V
A
T
--
L
L
M
H
M
L
Q
V
D
P
L
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
D
--------------
L
P
S
Y
L
F
P
----
E
D
P
S
Y
D
A
N
V
I
--
D
D
E
A
V
K
E
V
C
E
K
F
E
C
T
E
S
E
V
M
N
S
L
Y
S
G
D
P
--
Q
L
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
Q
A
S
E
F
Y
L
A
S
S
--------------------
R
P
H
P
E
R
V
----------------------------
K
A
K
W
H
L
G
I
R
S
Q
S
K
P
Y
D
I
M
A
E
V
Y
R
A
M
K
Q
L
D
F
E
W
K
V
V
N
A
Y
H
L
R
V
R
R
K
N
P
V
T
G
N
Y
V
K
M
S
L
Q
L
Y
L
V
D
N
R
S
Y
L
L
D
F
K
S
I
D
D
E
--------------------------------------------------------
P
R
L
G
S
H
T
M
D
F
F
E
M
C
A
S
L
I
T
T
L
A
-
12
PsiBlast_PDB
86.12
89%
-114
- C5 -
-
6C9H
8.9
-
AAPK1_HUMAN
A:
[9-493]
-------------------
G
S
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
R
R
E
I
Q
N
L
K
-
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
---
K
--
I
A
D
F
G
L
S
-
N
M
----
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
--
L
F
K
-
K
I
--
C
D
G
--
I
--
F
-
Y
T
P
Q
----
Y
----
L
N
--
P
------
S
--
V
I
S
--
L
L
K
H
M
L
Q
V
D
P
M
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
D
--------------
L
P
K
Y
L
F
P
----
E
D
P
S
Y
S
S
T
M
I
--
D
D
E
A
L
K
E
V
--------------
L
Y
N
R
N
H
Q
D
P
L
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
F
Y
L
A
T
S
P
------------------
T
R
P
H
P
E
R
V
P
F
--------------------------
K
A
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
Y
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
E
L
T
P
---------
R
P
G
S
---------------------------------------------
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
-
25
Blastp_CBE
83.61
76%
-126
- C5 -
-
6B2E
7.4
-
AAPK2_HUMAN
A:
[22-564]
-------------------
G
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
K
R
E
I
Q
N
L
K
-
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
---
K
--
I
A
D
F
G
L
S
-
N
M
----
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
T
--
L
F
K
-
K
I
--
R
G
G
--
V
--
F
-
Y
I
P
E
----
Y
----
L
N
--
R
------
S
--
V
A
T
--
L
L
M
H
M
L
Q
V
D
P
L
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
G
--------------
L
P
S
Y
L
F
P
----
E
D
P
S
Y
D
A
N
V
I
--
D
D
E
A
V
K
E
V
C
E
K
F
E
C
T
E
S
E
V
M
N
S
L
Y
S
G
D
P
Q
-----
A
Y
H
L
I
I
D
N
R
R
I
M
N
Q
A
S
E
F
Y
L
A
S
S
P
------------------
L
K
P
H
P
E
R
M
P
P
L
I
A
----------------------
K
K
A
K
W
H
L
G
I
R
S
Q
S
K
P
Y
D
I
M
A
E
V
Y
R
A
M
K
Q
L
D
F
E
W
K
V
V
N
A
Y
H
L
R
V
R
R
K
N
P
V
T
G
N
Y
V
K
M
S
L
Q
L
Y
L
V
D
N
R
S
Y
L
L
D
F
K
S
I
D
D
-----------------------------------------------------------
L
G
S
H
T
M
D
F
F
E
M
C
A
S
L
I
T
T
L
A
-
573
HHSearch
83.20
99%
-118
- C5 -
-
6C9J
9.1
-
AAPK1_HUMAN
A:
[9-494]
-------------------
G
S
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
R
R
E
I
Q
N
L
K
-
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
---
K
--
I
A
D
F
G
L
S
-
N
M
----
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
--
L
F
K
-
K
I
--
C
D
G
--
I
--
F
-
Y
T
P
Q
----
Y
----
L
N
--
P
------
S
--
V
I
S
--
L
L
K
H
M
L
Q
V
D
P
M
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
D
--------------
L
P
K
Y
L
F
P
----
E
---------------------------------------------------------------------------------------
T
R
P
H
P
E
R
V
P
F
L
V
A
-----------------------
K
A
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
Y
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
E
L
T
P
------------------------------------------------------
R
P
G
S
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
Q
22
Blastp_CBE
82.96
76%
-123
- C5 -
-
5ISO
-
-
?
C:
[9-550]
-------------------
G
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
K
R
E
I
Q
N
L
K
-
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
---
K
--
I
A
D
F
G
L
S
-
N
M
----
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
T
--
L
F
K
-
K
I
--
R
G
G
--
V
--
F
-
Y
I
P
E
----
Y
----
L
N
--
R
------
S
--
V
A
T
--
L
L
M
H
M
L
Q
V
D
P
L
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
D
--------------
L
P
S
Y
L
F
P
----
E
D
P
S
Y
D
A
N
V
I
--
D
D
E
A
V
K
E
V
C
--
F
E
-----------------
Q
L
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
Q
A
S
E
F
Y
L
A
S
S
-------------------
L
K
P
H
P
E
R
M
P
P
L
I
---------------------
A
V
K
K
A
K
W
H
L
G
I
R
S
Q
S
K
P
Y
D
I
M
A
E
V
Y
R
A
M
K
Q
L
D
F
E
W
K
V
V
N
A
Y
H
L
R
V
R
R
K
N
P
V
T
G
N
Y
V
K
M
S
L
Q
L
Y
L
V
D
N
R
S
Y
L
L
D
F
K
S
I
D
D
----------------------------------------------------------
R
L
G
S
H
T
M
D
F
F
E
M
C
A
S
L
I
T
T
L
--
28
Blastp_CBE
82.86
76%
-89
- C5 -
-
4ZHX
-
-
AAPK2_HUMAN
C:
[22-564]
-------------------
G
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
K
R
E
I
Q
N
L
K
-
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
---
K
--
I
A
D
F
G
L
S
-
N
M
----
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
T
--
L
F
K
-
K
I
--
R
G
G
--
V
--
F
-
Y
I
P
E
----
Y
----
L
N
--
R
------
S
--
V
A
T
--
L
L
M
H
M
L
Q
V
D
P
L
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
G
--------------
L
P
S
Y
L
F
P
----
E
D
P
S
Y
D
A
N
V
I
--
D
D
E
A
V
K
E
V
C
---
E
C
T
E
S
E
V
M
N
S
L
Y
S
G
D
P
Q
D
Q
L
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
Q
A
S
E
F
Y
L
A
S
S
-----------
S
A
M
HIPPG
L
K
P
H
P
E
R
M
P
P
L
I
A
--------------------
A
V
K
K
A
K
W
H
L
G
I
R
S
Q
S
K
P
Y
D
I
M
A
E
V
Y
R
A
M
K
Q
L
D
F
E
W
K
V
V
N
A
Y
H
L
R
V
R
R
K
N
P
V
T
G
N
Y
V
K
M
S
L
Q
L
Y
L
V
D
N
R
S
Y
L
L
D
F
K
S
I
D
------------------------------------------------------------
L
G
S
H
T
M
D
F
F
E
M
C
A
S
L
I
T
T
L
A
-
571
HHSearch
82.75
75%
-123
- C5 -
-
5ISO
-
-
?
C:
[9-550]
-------------------
G
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
K
R
E
I
Q
N
L
K
-
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
---
K
--
I
A
D
F
G
L
S
-
N
M
----
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
T
--
L
F
K
-
K
I
--
R
G
G
--
V
--
F
-
Y
I
P
E
----
Y
----
L
N
--
R
------
S
--
V
A
T
--
L
L
M
H
M
L
Q
V
D
P
L
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
D
--------------
L
P
S
Y
L
F
P
----
E
D
P
S
Y
D
A
N
V
I
--
D
D
E
A
V
K
E
V
C
--
F
E
-----------------
Q
L
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
Q
A
S
E
F
Y
L
A
S
S
-------------------
L
K
P
H
P
E
R
M
P
P
L
I
---------------------
A
V
K
K
A
K
W
H
L
G
I
R
S
Q
S
K
P
Y
D
I
M
A
E
V
Y
R
A
M
K
Q
L
D
F
E
W
K
V
V
N
A
Y
H
L
R
V
R
R
K
N
P
V
T
G
N
Y
V
K
M
S
L
Q
L
Y
L
V
D
N
R
S
Y
L
L
D
F
K
S
I
D
D
----------------------------------------------------------
R
L
G
S
H
T
M
D
F
F
E
M
C
A
S
L
I
T
T
L
--
19
PsiBlast_PDB
82.12
75%
-125
- C5 -
-
4CFE
-
-
AAPK2_HUMAN
A:
[27-570]
------------------
D
G
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
K
R
E
I
Q
N
L
K
-
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
---
K
--
I
A
D
F
G
L
S
-
N
M
----
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
T
--
L
F
K
-
K
I
--
R
G
G
--
V
--
F
-
Y
I
P
E
----
Y
----
L
N
--
R
------
S
--
V
A
T
--
L
L
M
H
M
L
Q
V
D
P
L
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
D
--------------
L
P
S
Y
L
F
P
----
E
D
P
S
Y
D
A
N
V
I
--
D
D
E
A
V
K
E
-------------------------
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
Q
A
S
E
F
Y
L
A
S
S
P
------------------
L
K
P
H
P
E
R
M
P
P
L
I
A
D
-------------------
A
V
K
K
A
K
W
H
L
G
I
R
S
Q
S
K
P
Y
D
I
M
A
E
V
Y
R
A
M
K
Q
L
D
F
E
W
K
V
V
N
A
Y
H
L
R
V
R
R
K
N
P
V
T
G
N
Y
V
K
M
S
L
Q
L
Y
L
V
D
N
R
S
Y
L
L
D
F
K
S
I
D
------------------------------------------------------------
L
G
S
H
T
M
D
F
F
E
M
C
A
S
L
I
T
T
L
A
-
14
PsiBlast_PDB
81.70
89%
-127
- C5 -
-
6C9G
9.3
-
AAPK1_HUMAN
A:
[9-493]
-------------------
G
S
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
R
R
E
I
Q
N
L
K
-
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
---
K
--
I
A
D
F
G
L
S
-
N
M
----
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
--
L
F
K
-
K
I
--
C
D
G
--
I
--
F
-
Y
T
P
Q
----
Y
----
L
N
--
P
------
S
--
V
I
S
--
L
L
K
H
M
L
Q
V
D
P
M
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
D
--------------
L
P
K
Y
L
F
P
----
E
--------------------------------------------------
I
D
N
R
R
I
M
N
E
A
K
D
F
-----------------------------------------------------------
R
K
A
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
Y
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
E
L
T
P
---------
R
P
G
S
---------------------------------------------
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
-
16
PsiBlast_PDB
81.46
98%
-123
- C5 -
-
4CFH
8.5
-
AAPK1_RAT
A:
[29-489]
--------------------
R
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
R
R
E
I
Q
N
L
K
-
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
---
K
--
I
A
D
F
G
L
S
-
N
M
----
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
--
L
F
K
-
K
I
--
C
D
G
--
I
--
F
-
Y
T
P
Q
----
Y
----
L
N
--
P
------
S
--
V
I
S
--
L
L
K
H
M
L
Q
V
D
P
M
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
D
--------------
L
P
K
Y
L
F
P
----
E
D
------------------------------------------
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
F
Y
L
A
T
S
P
P
D
S
F
L
D
D
---
H
H
L
-----
T
R
P
H
P
E
R
V
P
F
L
V
A
E
T
P
R
A
-------------------
A
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
F
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
E
I
------------------------------------------------------------------------------
13
PsiBlast_PDB
81.23
89%
-127
- C5 -
-
6C9F
9.2
-
AAPK1_HUMAN
A:
[9-493]
-------------------
G
S
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
R
R
E
I
Q
N
L
K
-
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
---
K
--
I
A
D
F
G
L
S
-
N
M
----
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
--
L
F
K
-
K
I
--
C
D
G
--
I
--
F
-
Y
T
P
Q
----
Y
----
L
N
--
P
------
S
--
V
I
S
--
L
L
K
H
M
L
Q
V
D
P
M
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
D
--------------
L
P
K
Y
L
F
P
----
E
D
--------------------------------------------------------------------------------------------------------------------------
K
A
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
Y
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
E
L
T
P
---------
R
P
G
S
---------------------------------------------
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
-
15
PsiBlast_PDB
81.22
89%
-118
- C5 -
-
6C9J
9.1
-
AAPK1_HUMAN
A:
[9-494]
-------------------
G
S
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
R
R
E
I
Q
N
L
K
-
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
---
K
--
I
A
D
F
G
L
S
-
N
M
----
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
--
L
F
K
-
K
I
--
C
D
G
--
I
--
F
-
Y
T
P
Q
----
Y
----
L
N
--
P
------
S
--
V
I
S
--
L
L
K
H
M
L
Q
V
D
P
M
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
D
--------------
L
P
K
Y
L
F
P
----
E
---------------------------------------------------------------------------------------
T
R
P
H
P
E
R
V
P
F
L
V
A
-----------------------
K
A
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
Y
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
E
L
T
P
---------
R
P
G
S
---------------------------------------------
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
Q
1
PsiBlast_PDB
80.88
99%
-104
- C5 -
-
4REW
8.9
-
AAPK1_HUMAN
A:
[1-540]
-------------------
G
S
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
R
R
E
I
Q
N
L
K
-
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
---
K
--
I
A
D
F
G
L
S
-
N
M
----
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
--
L
F
K
-
K
I
--
C
D
G
--
I
--
F
-
Y
T
P
Q
----
Y
----
L
N
--
P
------
S
--
V
I
S
--
L
L
K
H
M
L
Q
V
D
P
M
K
-----
R
-----
A
-----
S
I
K
D
I
R
E
H
E
W
F
K
-----
Q
D
--------------
L
P
K
Y
L
F
P
----
E
--------------------------------------------------
I
D
N
R
R
I
M
N
E
A
K
D
F
Y
L
A
T
S
P
P
-----
D
---
H
H
L
-----
T
R
P
H
P
E
R
V
P
F
L
V
A
E
T
--------------------
R
K
A
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
Y
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
G
--------------------------------------------------------
P
R
P
G
S
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
Q
8
PsiBlast_PDB
79.65
89%
-123
- C5 -
-
5UFU
9.4
-
AAPK1_MOUSE (first)
A:
[11-503]
-------------------
G
R
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
R
R
E
I
Q
N
L
K
-
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
---
K
--
I
A
D
F
G
L
S
-
N
M
----
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
--
L
F
K
-
K
I
--
C
D
G
--
I
--
F
-
Y
T
P
Q
----
Y
----
L
N
--
P
------
S
--
V
I
S
--
L
L
K
H
M
L
Q
V
D
P
M
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
D
--------------
L
P
K
Y
L
F
P
----
E
----------------------------------------------------------------------------------------------------------------------------
A
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
F
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
E
------------
R
P
G
S
---------------------------------------------
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
Q
7
PsiBlast_PDB
78.64
89%
-120
- C5 -
-
5T5T
9.7
-
AAPK1_RAT
A:
[11-503]
-------------------
G
R
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
R
R
E
I
Q
N
L
K
-
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
---
K
--
I
A
D
F
G
L
S
-
N
M
----
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
--
L
F
K
-
K
I
--
C
D
G
--
I
--
F
-
Y
T
P
Q
----
Y
----
L
N
--
P
------
S
--
V
I
S
--
L
L
K
H
M
L
Q
V
D
P
M
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
D
--------------
L
P
K
Y
L
F
P
----
E
----------------------------------------------------------------------------------------------------------------------------
A
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
F
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
E
------------
R
P
G
S
---------------------------------------------
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
Q
11
PsiBlast_PDB
78.57
89%
-127
- C5 -
-
6E4W
9.0
-
?
A:
[11-503]
-------------------
G
R
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
R
R
E
I
Q
N
L
K
-
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
---
K
--
I
A
D
F
G
L
S
-
N
M
----
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
--
L
F
K
-
K
I
--
C
D
G
--
I
--
F
-
Y
T
P
Q
----
Y
----
L
N
--
P
------
S
--
V
I
S
--
L
L
K
H
M
L
Q
V
D
P
M
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
D
--------------
L
P
K
Y
L
F
-----------------------------------------------------------------------------------------------------------------------------------
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
F
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
----------------
S
---------------------------------------------
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
Q
10
PsiBlast_PDB
78.54
89%
-123
- C5 -
-
6E4U
9.4
-
AAPK1_RAT
A:
[11-503]
-------------------
G
R
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
R
R
E
I
Q
N
L
K
-
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
---
K
--
I
A
D
F
G
L
S
-
N
M
----
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
--
L
F
K
-
K
I
--
C
D
G
--
I
--
F
-
Y
T
P
Q
----
Y
----
L
N
--
P
------
S
--
V
I
S
--
L
L
K
H
M
L
Q
V
D
P
M
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
D
--------------
L
P
K
Y
L
F
P
----
E
-----------------------------------------------------------------------------------------------------------------------------
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
F
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
--------------
P
G
S
---------------------------------------------
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
Q
4
PsiBlast_PDB
78.21
89%
-125
- C5 -
-
4QFR
10.3
-
?
A:
[11-503]
-------------------
G
R
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
R
R
E
I
Q
N
L
K
-
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
---
K
--
I
A
D
F
G
L
S
-
N
M
----
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
--
L
F
K
-
K
I
--
C
D
G
--
I
--
F
-
Y
T
P
Q
----
Y
----
L
N
--
P
------
S
--
V
I
S
--
L
L
K
H
M
L
Q
V
D
P
M
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
D
--------------
L
P
K
Y
L
F
-----------------------------------------------------------------------------------------------------------------------------------
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
F
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
----------------
S
---------------------------------------------
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
Q
3
PsiBlast_PDB
78.21
89%
-121
- C5 -
-
4QFG
9.6
-
AAPK1_RAT
A:
[11-503]
-------------------
G
R
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
R
R
E
I
Q
N
L
K
-
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
---
K
--
I
A
D
F
G
L
S
-
N
M
----
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
--
L
F
K
-
K
I
--
C
D
G
--
I
--
F
-
Y
T
P
Q
----
Y
----
L
N
--
P
------
S
--
V
I
S
--
L
L
K
H
M
L
Q
V
D
P
M
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
D
--------------
L
P
K
Y
L
F
P
-----------------------------------------------------------------------------------------------------------------------------------
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
F
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
E
------------
R
P
G
S
---------------------------------------------
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
Q
9
PsiBlast_PDB
78.12
89%
-128
- C5 -
-
6E4T
9.1
-
?
A:
[11-503]
-------------------
G
R
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
R
R
E
I
Q
N
L
K
-
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
---
K
--
I
A
D
F
G
L
S
-
N
M
----
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
--
L
F
K
-
K
I
--
C
D
G
--
I
--
F
-
Y
T
P
Q
----
Y
----
L
N
--
P
------
S
--
V
I
S
--
L
L
K
H
M
L
Q
V
D
P
M
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
D
--------------
L
P
K
Y
L
F
-----------------------------------------------------------------------------------------------------------------------------------
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
F
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
----------------
S
---------------------------------------------
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
Q
5
PsiBlast_PDB
77.73
89%
-126
- C5 -
-
4QFS
9.7
-
AAPK1_RAT
A:
[11-503]
-------------------
G
R
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
R
R
E
I
Q
N
L
K
-
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
---
K
--
I
A
D
F
G
L
S
-
N
M
----
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
--
L
F
K
-
K
I
--
C
D
G
--
I
--
F
-
Y
T
P
Q
----
Y
----
L
N
--
P
------
S
--
V
I
S
--
L
L
K
H
M
L
Q
V
D
P
M
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
D
--------------
L
P
K
Y
L
F
-----------------------------------------------------------------------------------------------------------------------------------
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
F
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
----------------
S
---------------------------------------------
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
Q
6
PsiBlast_PDB
77.18
89%
-124
- C5 -
-
5KQ5
9.5
-
?
A:
[12-503]
--------------------
R
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
R
R
E
I
Q
N
L
K
-
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
---
K
--
I
A
D
F
G
L
S
-
N
M
----
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
--
L
F
K
-
K
I
--
C
D
G
--
I
--
F
-
Y
T
P
Q
----
Y
----
L
N
--
P
------
S
--
V
I
S
--
L
L
K
H
M
L
Q
V
D
P
M
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
D
--------------
L
P
K
Y
L
F
----------------------------------------------------------------------------------------------------------------------------------
A
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
F
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
---------------
P
G
S
---------------------------------------------
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
Q
31
Blastp_CBE
63.77
90%
-132
- C5 -
-
3AQV
8.2
-
AAPK2_HUMAN
A:
[4-276]
-----------------
H
D
G
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
K
R
E
I
Q
N
L
K
-
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
---
K
--
I
A
D
F
G
L
S
-
N
M
----
M
---
S
D
G
---
E
F
L
------
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
T
--
L
F
K
-
K
I
--
R
G
G
--
V
--
F
-
Y
I
P
E
----
Y
----
L
N
--
R
------
S
--
V
A
T
--
L
L
M
H
M
L
Q
V
D
P
L
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
D
--------------
L
P
S
Y
L
F
P
----
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
Blastp_CBE
59.00
90%
-136
- C5 -
-
6BX6
6.6
-
AAPK2_HUMAN
A:
[10-274]
-----------------------
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
K
R
E
I
Q
N
L
K
-
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
---
K
--
I
A
D
F
G
L
S
---------------------------
N
Y
A
A
P
E
------
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
T
--
L
F
K
-
K
I
--
R
G
G
--
V
--
F
-
Y
I
P
E
----
Y
----
L
N
--
R
------
S
--
V
A
T
--
L
L
M
H
M
L
Q
V
D
P
L
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
D
--------------
L
P
S
Y
L
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
588
HHSearch
57.83
42%
-133
- C5 -
-
5TVT
8.7
-
MELK_HUMAN
A:
[5-328]
-------------------
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
L
G
--
S
D
L
P
R
-
I
K
T
E
I
E
A
L
K
-
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
---
K
--
L
I
D
F
G
L
C
-
A
K
---------------------
G
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
--
L
Y
K
-
K
I
--
M
R
G
--
K
--
Y
-
D
V
P
K
----
W
----
L
S
--
P
------
S
--
S
I
L
--
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
D
--------------
Y
N
Y
P
V
E
W
----
Q
S
K
N
-
P
F
I
H
L
--
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
-
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
586
HHSearch
55.35
42%
-124
- C5 -
-
5K00
10.8
-
MELK_HUMAN
A:
[4-326]
--------------------
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
L
G
--
S
D
L
P
R
-
I
K
T
E
I
E
A
L
K
-
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
---
K
--
L
I
D
F
G
L
C
-
A
K
----
P
-----------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
--
L
Y
K
-
K
I
--
M
R
G
--
K
--
Y
-
D
V
P
K
----
W
----
L
S
--
P
------
S
--
S
I
L
--
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
D
--------------
Y
N
Y
P
V
E
W
----
Q
S
K
N
-
P
F
I
H
L
--
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
-
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
Blastp_CBE
54.85
47%
-138
- C5 -
-
5MAI
7.5
-
MELK_HUMAN
A:
[9-291]
-----------------------
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
L
G
S
--
D
L
P
R
-
I
K
T
E
I
E
A
L
K
-
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
---
K
--
L
I
D
F
----------------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
--
L
Y
K
-
K
I
--
M
R
G
--
K
--
Y
-
D
V
P
K
----
W
----
L
S
--
P
------
S
--
S
I
L
--
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
D
-----------------
Y
N
Y
P
----
V
E
W
Q
S
K
N
P
--HL
D
D
D
C
V
T
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
Blastp_CBE
54.47
47%
-127
- C5 -
-
5TWL
8.0
-
MELK_HUMAN
A:
[9-291]
-----------------------
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
L
G
S
--
D
L
P
R
-
I
K
T
E
I
E
A
L
K
-
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
---
K
--
L
I
D
F
G
L
------------------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
--
L
Y
K
-
K
I
--
M
R
G
--
K
--
Y
-
D
V
P
K
----
W
----
L
S
--
P
------
S
--
S
I
L
--
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
D
-----------------
Y
N
Y
P
----
V
E
W
Q
S
K
N
P
F
I
HL
D
D
D
C
V
T
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
Blastp_CBE
54.42
45%
-136
- C5 -
-
4UMQ
6.1
-
MELK_HUMAN
A:
[28-310]
-----------------------
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
L
G
S
--
D
L
P
R
-
I
K
T
E
I
E
A
L
K
-
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
---
K
--
L
I
D
F
G
L
------------------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
T
A
A
A
--
L
V
A
-
K
I
--
M
R
G
--
K
--
Y
-
D
V
P
K
----
W
----
L
S
--
P
------
S
--
S
I
L
--
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
D
-----------------
Y
N
Y
P
----
V
E
W
Q
S
K
N
P
F
I
HL
D
D
D
C
V
T
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
Blastp_CBE
54.23
48%
-134
- C5 -
-
4BFM
6.3
-
MELK_MOUSE
A:
[8-266]
-----------------------
L
K
Y
Y
E
L
Y
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
V
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
A
L
G
S
--
D
L
P
R
-
V
K
T
E
I
D
A
L
K
-
S
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
K
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
L
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
N
---
H
K
---
L
---
K
--
L
I
D
F
G
L
C
-
A
K
--------------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
----------
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
--
L
Y
K
-
K
I
--
M
R
G
--
K
--
Y
-
E
V
P
K
----
W
----
L
S
--
P
------
S
--
S
I
L
--
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
R
N
L
L
N
H
P
W
V
M
-----
Q
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
Blastp_CBE
54.13
48%
-136
- C5 -
-
4CQG
8.6
-
MELK_MOUSE
A:
[8-266]
-----------------------
L
K
Y
Y
E
L
Y
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
V
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
A
L
G
S
--
D
L
P
R
-
V
K
T
E
I
D
A
L
K
-
S
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
K
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
L
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
N
---
H
K
---
L
---
K
--
L
I
D
F
G
L
C
-
A
K
--------------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
----------
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
--
L
Y
K
-
K
I
--
M
R
G
--
K
--
Y
-
E
V
P
K
----
W
----
L
S
--
P
------
S
--
S
I
L
--
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
R
N
L
L
N
H
P
W
V
M
-----
Q
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
Blastp_CBE
54.11
46%
-137
- C5 -
-
4UMT
10.2
-
MELK_HUMAN
A:
[28-310]
-----------------------
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
L
G
S
--
D
L
P
R
-
I
K
T
E
I
E
A
L
K
-
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
---
K
--
L
I
D
F
G
L
------------------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
T
A
A
A
--
L
V
A
-
K
I
--
M
R
G
--
K
--
Y
-
D
V
P
K
----
W
----
L
S
--
P
------
S
--
S
I
L
--
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
D
-----------------
Y
N
Y
P
----
V
E
W
Q
S
K
N
P
F
I
HL
D
D
D
C
V
T
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
Blastp_CBE
53.80
47%
-128
- C5 -
-
5TVT
8.7
-
MELK_HUMAN
A:
[9-291]
-----------------------
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
L
G
S
--
D
L
P
R
-
I
K
T
E
I
E
A
L
K
-
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
---
K
--
L
I
D
F
G
L
C
-
A
K
---------------------
G
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
--
L
Y
K
-
K
I
--
M
R
G
--
K
--
Y
-
D
V
P
K
----
W
----
L
S
--
P
------
S
--
S
I
L
--
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
D
-----------------
Y
N
Y
P
----
V
E
W
Q
S
K
N
P
F
I
HL
D
D
D
C
V
T
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
Blastp_CBE
53.78
45%
-140
- C5 -
-
4UMR
5.3
-
MELK_HUMAN
A:
[28-310]
-----------------------
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
L
G
S
--
D
L
P
R
-
I
K
T
E
I
E
A
L
K
-
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
---
K
--
L
I
D
F
G
L
------------------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
T
A
A
A
--
L
V
A
-
K
I
--
M
R
G
--
K
--
Y
-
D
V
P
K
----
W
----
L
S
--
P
------
S
--
S
I
L
--
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
D
-----------------
Y
N
Y
P
----
V
E
W
Q
S
K
N
P
F
I
HL
D
D
D
C
V
T
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Blastp_CBE
53.70
47%
-122
- C5 -
-
5K00
10.8
-
MELK_HUMAN
A:
[7-289]
-----------------------
L
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
L
G
S
--
D
L
P
R
-
I
K
T
E
I
E
A
L
K
-
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
---
K
--
L
I
D
F
G
L
C
-
A
K
----
P
-----------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
--
L
Y
K
-
K
I
--
M
R
G
--
K
--
Y
-
D
V
P
K
----
W
----
L
S
--
P
------
S
--
S
I
L
--
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
D
-----------------
Y
N
Y
P
----
V
E
W
Q
S
K
N
P
F
I
HL
D
D
D
C
V
T
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
Blastp_CBE
53.42
47%
-137
- C5 -
-
5TWZ
5.8
-
MELK_HUMAN
A:
[9-291]
-----------------------
L
K
Y
Y
E
L
H
E
T
I
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
L
G
S
--
D
L
P
R
-
I
K
T
E
I
E
A
L
K
-
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
---
K
--
L
I
D
F
G
--------------------------
G
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
--
L
Y
K
-
K
I
--
M
R
G
--
K
--
Y
-
D
V
P
K
----
W
----
L
S
--
P
------
S
--
S
I
L
--
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
D
-----------------
Y
N
Y
P
----
V
E
W
Q
S
K
N
P
F
I
HL
D
D
D
C
V
T
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
Blastp_CBE
53.39
47%
-128
- C5 -
-
5MAH
6.2
-
MELK_HUMAN
A:
[9-291]
-----------------------
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
L
G
S
--
D
L
P
R
-
I
K
T
E
I
E
A
L
K
-
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
---
K
--
L
I
D
F
G
L
C
-
A
K
----------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
--
L
-----
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
--
L
Y
K
-
K
I
--
M
R
G
--
K
--
Y
-
D
V
P
K
----
W
----
L
S
--
P
------
S
--
S
I
L
--
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
D
-----------------
Y
N
Y
P
----
V
E
W
Q
S
K
N
P
F
I
HL
D
D
D
C
V
T
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
Blastp_CBE
53.11
47%
-132
- C5 -
-
5IHC
6.7
-
MELK_HUMAN
A:
[7-289]
-----------------------
L
K
Y
Y
E
L
H
E
T
I
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
L
G
S
--
D
L
P
R
-
I
K
T
E
I
E
A
L
K
-
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
---
K
--
L
I
D
F
---------------------------
G
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
--
L
Y
K
-
K
I
--
M
R
G
--
K
--
Y
-
D
V
P
K
----
W
----
L
S
--
P
------
S
--
S
I
L
--
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
D
-----------------
Y
N
Y
P
----
V
E
W
Q
S
K
N
P
F
I
HL
D
D
D
C
V
T
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
Blastp_CBE
52.89
46%
-133
- C5 -
-
4UMU
9.5
-
MELK_HUMAN
A:
[28-310]
-----------------------
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
L
G
S
--
D
L
P
R
-
I
K
T
E
I
E
A
L
K
-
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
---
K
--
L
I
D
F
G
L
------------------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
T
A
A
A
--
L
V
A
-
K
I
--
M
R
G
--
K
--
Y
-
D
V
P
K
----
W
----
L
S
--
P
------
S
--
S
I
L
--
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
D
-----------------
Y
N
Y
P
----
V
E
W
Q
S
K
N
P
F
I
HL
D
D
D
C
V
T
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
Blastp_CBE
52.86
47%
-127
- C5 -
-
5IH8
6.4
-
MELK_HUMAN
A:
[7-289]
-----------------------
L
K
Y
Y
E
L
H
E
T
I
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
-----
D
L
P
R
-
I
K
T
E
I
E
A
L
K
-
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
---
K
--
L
I
D
F
G
L
C
-
A
K
----------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
--
L
Y
K
-
K
I
--
M
R
G
--
K
--
Y
-
D
V
P
K
----
W
----
L
S
--
P
------
S
--
S
I
L
--
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
D
-----------------
Y
N
Y
P
----
V
E
W
Q
S
K
N
P
F
I
HL
D
D
D
C
V
T
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
Blastp_CBE
52.85
47%
-129
- C5 -
-
5M5A
8.4
-
MELK_HUMAN
A:
[9-291]
-----------------------
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
L
G
S
--
D
L
P
R
-
I
K
T
E
I
E
A
L
K
-
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
---
K
--
L
I
D
F
G
L
C
-
A
-----------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
--
L
-----
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
--
L
Y
K
-
K
I
--
M
R
G
--
K
--
Y
-
D
V
P
K
----
W
----
L
S
--
P
------
S
--
S
I
L
--
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
D
-----------------
Y
N
Y
P
----
V
E
W
Q
S
K
N
P
F
I
HL
D
D
D
C
V
T
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
Blastp_CBE
52.64
47%
-128
- C5 -
-
4BKZ
5.4
-
MELK_HUMAN
A:
[9-291]
-----------------------
L
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
L
-----
L
P
R
-
I
K
T
E
I
E
A
L
K
-
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
---
K
--
L
I
D
F
G
L
C
-
A
-----------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
---------
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
--
L
Y
K
-
K
I
--
M
R
G
--
K
--
Y
-
D
V
P
K
----
W
----
L
S
--
P
------
S
--
S
I
L
--
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
D
-----------------
Y
N
Y
P
----
V
E
W
Q
S
K
N
P
F
I
HL
D
D
D
C
V
T
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
Blastp_CBE
52.54
47%
-127
- C5 -
-
4BKY
7.9
-
MELK_HUMAN
A:
[9-291]
-----------------------
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
L
----
D
L
P
R
-
I
K
T
E
I
E
A
L
K
-
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
---
K
--
L
I
D
F
G
L
C
-
A
-----------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
--------
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
--
L
Y
K
-
K
I
--
M
R
G
--
K
--
Y
-
D
V
P
K
----
W
----
L
S
--
P
------
S
--
S
I
L
--
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
D
-----------------
Y
N
Y
P
----
V
E
W
Q
S
K
N
P
F
I
HL
D
D
D
C
V
T
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Blastp_CBE
52.51
45%
-116
- C5 -
-
5KZ8
7.8
-
MARK2_HUMAN
A:
[30-315]
----------------
P
H
-----
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
----
K
T
Q
L
N
S
-
S
S
L
Q
K
-
L
F
R
E
V
R
I
M
K
-
V
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
-----
D
---
A
D
---
M
N
---
I
---
K
--
I
A
D
F
G
-------------------------
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-----
G
--
P
E
-------
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
K
E
--
L
R
E
-
R
V
--
L
R
G
--
K
--
Y
-
R
I
P
F
----
Y
----
M
S
--
T
------
D
--
C
E
N
--
L
L
K
K
F
L
I
L
N
P
S
K
-----
R
-----
G
-----
T
L
E
Q
I
M
K
D
R
W
M
N
VGHED
D
E
--------------
L
K
P
Y
V
E
P
LPDY
K
D
P
R
R
T
E
L
M
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
Blastp_CBE
52.26
47%
-124
- C5 -
-
5IH9
6.7
-
MELK_HUMAN
A:
[7-289]
-----------------------
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
------
L
P
R
-
I
K
T
E
I
E
A
L
K
-
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
---
K
--
L
I
D
F
G
L
C
-
A
K
----------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
--
L
Y
K
-
K
I
--
M
R
G
--
K
--
Y
-
D
V
P
K
----
W
----
L
S
--
P
------
S
--
S
I
L
--
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
D
-----------------
Y
N
Y
P
----
V
E
W
Q
S
K
N
P
F
I
HL
D
D
D
C
V
T
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Blastp_CBE
52.20
45%
-123
- C5 -
-
5KZ7
7.7
-
MARK2_HUMAN
B:
[30-315]
----------------
P
H
-----
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
----
K
T
Q
L
N
S
-
S
S
L
Q
K
-
L
F
R
E
V
R
I
M
K
-
V
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
-----
D
---
A
D
---
M
N
---
I
---
K
--
I
A
D
F
---------------------------
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
--
D
-----
G
--
P
E
-------
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
--
N
L
K
E
--
L
R
E
-
R
V
--
L
R
G
--
K
--
Y
-
R
I
P
F
----
Y
----
M
S
--
T
------
D
--
C
E
N
--
L
L
K
K
F
L
I
L
N
P
S
K
-----
R
-----
G
-----
T
L
E
Q
I
M
K
D
R
W
M
N
VGHED
D
E
--------------
L
K
P
Y
V
E
P
LPDY
K
D
P
R
R
T
E
L
M
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
Blastp_CBE
52.15
47%
-128
- C5 -
-
4BL1
6.5
-
MELK_HUMAN
A:
[9-291]
-----------------------
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
L
-----
L
P
R
-
I
K
T
E
I
E
A
L
K
-
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
---
K
--
L
I
D
F
G
L
C
-
A
K
----------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
--------
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
--
L
Y
K
-
K
I
--
M
R
G
--
K
--
Y
-
D
V
P
K
----
W
----
L
S
--
P
------
S
--
S
I
L
--
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
D
-----------------
Y
N
Y
P
----
V
E
W
Q
S
K
N
P
F
I
HL
D
D
D
C
V
T
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
Blastp_CBE
52.13
47%
-128
- C5 -
-
5IHA
6.9
-
MELK_HUMAN
A:
[7-289]
-----------------------
L
K
Y
Y
E
L
H
E
T
I
G
----
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
L
-------
R
-
I
K
T
E
I
E
A
L
K
-
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
---
K
--
L
I
D
F
G
L
C
-
A
K
----------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
--
L
Y
K
-
K
I
--
M
R
G
--
K
--
Y
-
D
V
P
K
----
W
----
L
S
--
P
------
S
--
S
I
L
--
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
D
-----------------
Y
N
Y
P
----
V
E
W
Q
S
K
N
P
F
I
HL
D
D
D
C
V
T
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Blastp_CBE
52.10
45%
-121
- C5 -
-
5KZ7
7.9
-
MARK2_HUMAN
A:
[30-315]
----------------
P
H
-----
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
----
K
T
Q
L
N
S
-
S
S
L
Q
K
-
L
F
R
E
V
R
I
M
K
-
V
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
-----
D
---
A
D
---
M
N
---
I
---
K
--
I
A
D
F
---------------------------
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
--
D
-----
G
--
P
E
-------
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
--
N
L
K
E
--
L
R
E
-
R
V
--
L
R
G
--
K
--
Y
-
R
I
P
F
----
Y
----
M
S
--
T
------
D
--
C
E
N
--
L
L
K
K
F
L
I
L
N
P
S
K
-----
R
-----
G
-----
T
L
E
Q
I
M
K
D
R
W
M
N
VGHED
D
E
--------------
L
K
P
Y
V
E
P
LPDY
K
D
P
R
R
T
E
L
M
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Blastp_CBE
52.10
45%
-115
- C5 -
-
5KZ8
7.6
-
MARK2_HUMAN
B:
[30-315]
----------------
P
H
-----
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
----
K
T
Q
L
N
S
-
S
S
L
Q
K
-
L
F
R
E
V
R
I
M
K
-
V
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
-----
D
---
A
D
---
M
N
---
I
---
K
--
I
A
D
F
---------------------------
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-----
G
--
P
E
-------
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
K
E
--
L
R
E
-
R
V
--
L
R
G
--
K
--
Y
-
R
I
P
F
----
Y
----
M
S
--
T
------
D
--
C
E
N
--
L
L
K
K
F
L
I
L
N
P
S
K
-----
R
-----
G
-----
T
L
E
Q
I
M
K
D
R
W
M
N
VGHED
D
E
--------------
L
K
P
Y
V
E
P
LPDY
K
D
P
R
R
T
E
L
M
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
Blastp_CBE
52.04
47%
-125
- C5 -
-
5MAG
6.6
-
MELK_HUMAN
A:
[9-291]
-----------------------
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
-
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
L
----
D
L
P
R
-
I
K
T
E
I
E
A
L
K
-
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
---
K
--
L
I
D
F
G
L
C
-
A
K
----------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
--
L
-----
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
--
L
Y
K
-
K
I
--
M
R
G
--
K
--
Y
-
D
V
P
K
----
W
----
L
S
--
P
------
S
--
S
I
L
--
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
D
-----------------
Y
N
Y
P
----
V
E
W
Q
S
K
N
P
F
I
HL
D
D
D
C
V
T
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
Blastp_CBE
52.01
47%
-116
- C5 -
-
6GVX
7.1
-
MELK_HUMAN
B:
[12-294]
-----------------------
L
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
--
S
--
D
L
P
R
-
I
K
T
E
I
E
A
L
K
-
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
---
K
--
L
I
D
F
G
L
C
-
A
K
----
P
----------------
G
S
L
A
Y
A
A
P
E
L
I
Q
G
---------
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
--
L
Y
K
-
K
I
--
M
R
G
--
K
--
Y
-
D
V
P
K
----
W
----
L
S
--
P
------
S
--
S
I
L
--
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
D
-----------------
Y
N
Y
P
----
V
E
W
Q
S
K
N
P
F
I
HL
D
D
D
C
V
T
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
Blastp_CBE
51.76
47%
-131
- C5 -
-
5TWY
5.9
-
MELK_HUMAN
A:
[9-291]
-----------------------
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
-----
D
L
P
R
-
I
K
T
E
I
E
A
L
K
-
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
---
K
--
L
I
D
F
G
L
------------------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
G
K
--------
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
--
L
Y
K
-
K
I
--
M
R
G
--
K
--
Y
-
D
V
P
K
----
W
----
L
S
--
P
------
S
--
S
I
L
--
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
D
-----------------
Y
N
Y
P
----
V
E
W
Q
S
K
N
P
F
I
HL
D
D
D
C
V
T
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
Blastp_CBE
51.59
45%
-111
- C5 -
-
5EAK
8.5
-
MARK2_HUMAN
B:
[15-297]
------------------------
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
----
K
T
Q
L
N
S
-
S
S
L
Q
K
-
L
F
R
E
V
R
I
M
K
-
V
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
-----
D
---
A
D
---
M
N
---
I
---
K
--
I
A
D
F
G
------------------------
F
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-----
G
--
P
E
-------
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
K
E
--
L
R
E
-
R
V
--
L
R
G
--
K
--
Y
-
R
I
P
F
----
Y
----
M
S
--
T
------
D
--
C
E
N
--
L
L
K
K
F
L
I
L
N
P
S
K
-----
R
-----
G
-----
T
L
E
Q
I
M
K
D
R
W
M
N
VGHED
D
E
--------------
L
K
P
Y
V
E
P
LPDY
K
D
P
R
R
T
E
L
M
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
Blastp_CBE
51.05
45%
-118
- C5 -
-
5ES1
8.8
-
MARK4_HUMAN
A:
[12-285]
----------------
P
H
-----
V
G
N
Y
R
L
L
R
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
R
E
V
A
I
K
I
I
D
----
K
T
Q
L
N
P
-
S
S
L
Q
K
-
L
F
R
E
V
R
I
M
K
-
G
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
A
G
E
V
F
D
Y
L
V
S
H
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
H
Y
C
H
Q
K
N
I
V
H
R
D
L
K
A
E
N
L
L
---
L
-----
D
---
A
E
---
A
N
---
I
---
K
--
I
A
D
F
G
F
S
-
N
-----------------------
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-----
G
--
P
E
-------
V
D
I
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
H
N
L
K
E
--
L
R
E
-
R
V
--
L
R
G
--
K
--
Y
-
R
V
P
F
----
Y
----
M
S
--
T
------
D
--
C
E
S
--
I
L
R
R
F
L
V
L
N
P
A
K
-----
R
-----
C
-----
T
L
E
Q
I
M
K
D
K
W
I
N
IGYEG
E
E
--------------
L
K
P
Y
T
E
P
----
E
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
Blastp_CBE
50.98
47%
-135
- C5 -
-
5TX3
3.9
-
MELK_HUMAN
A:
[12-294]
-----------------------
L
K
Y
Y
E
L
H
E
T
I
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
-----------
I
K
T
E
I
E
A
L
K
-
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
---
K
--
L
I
D
F
G
L
-------------------------
G
S
L
A
Y
A
A
P
E
L
I
Q
G
K
--------
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
--
L
Y
K
-
K
I
--
M
R
G
--
K
--
Y
-
D
V
P
K
----
W
----
L
S
--
P
------
S
--
S
I
L
--
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
D
-----------------
Y
N
Y
P
----
V
E
W
Q
S
K
N
P
F
I
HL
D
D
D
C
V
T
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
Blastp_CBE
50.93
47%
-124
- C5 -
-
5MAF
7.0
-
MELK_HUMAN
A:
[9-291]
-----------------------
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
L
----
D
L
P
R
-
I
K
T
E
I
E
A
L
K
-
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
---
K
--
L
I
D
F
G
L
C
-
A
K
----------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
--
L
-----
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
--
L
Y
K
-
K
I
--
M
R
G
--
K
--
Y
-
D
V
P
K
----
W
----
L
S
--
P
------
S
--
S
I
L
--
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
D
-----------------
Y
N
Y
P
----
V
E
W
Q
S
K
N
P
F
I
HL
D
D
D
C
V
T
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Blastp_CBE
50.85
45%
-105
- C5 -
-
5EAK
8.0
-
MARK2_HUMAN
A:
[11-297]
---------------
Q
P
H
-----
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
----
K
T
Q
L
N
S
-
S
S
L
Q
K
-
L
F
R
E
V
R
I
M
K
-
V
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
-----
D
---
A
D
---
M
N
---
I
---
K
--
I
A
D
F
G
F
S
----------------------
F
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-----
G
--
P
E
-------
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
K
E
--
L
R
E
-
R
V
--
L
R
G
--
K
--
Y
-
R
I
P
F
----
Y
----
M
S
--
T
------
D
--
C
E
N
--
L
L
K
K
F
L
I
L
N
P
S
K
-----
R
-----
G
-----
T
L
E
Q
I
M
K
D
R
W
M
N
VGHED
D
E
--------------
L
K
P
Y
V
E
P
LPDY
K
D
P
R
R
T
E
L
M
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
Blastp_CBE
50.68
47%
-132
- C5 -
-
5TX3
8.0
-
MELK_HUMAN
B:
[12-294]
-----------------------
L
K
Y
Y
E
L
H
E
T
I
G
-----
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
-------------
K
T
E
I
E
A
L
K
-
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
---
K
--
L
I
D
----------------------------
G
S
L
A
Y
A
A
P
E
L
I
Q
G
---
L
-----
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
--
L
Y
K
-
K
I
--
M
R
G
--
K
--
Y
-
D
V
P
K
----
W
----
L
S
--
P
------
S
--
S
I
L
--
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
D
-----------------
Y
N
Y
P
----
V
E
W
Q
S
K
N
P
F
I
HL
D
D
D
C
V
T
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
Blastp_CBE
50.19
47%
-129
- C5 -
-
5TWY
6.9
-
MELK_HUMAN
B:
[9-291]
-----------------------
L
K
Y
Y
E
L
H
E
T
I
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
------
D
L
P
R
-
I
K
T
E
I
E
A
L
K
-
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
---
K
--
L
I
D
F
G
L
C
--------------------------
L
A
Y
A
A
P
E
L
I
Q
G
K
--------
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
--
L
Y
K
-
K
I
--
M
R
G
--
K
--
Y
-
D
V
P
K
----
W
----
L
S
--
P
------
S
--
S
I
L
--
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
D
-----------------
Y
N
Y
P
----
V
E
W
Q
S
K
N
P
F
I
HL
D
D
D
C
V
T
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
314
Blastp_CBE
50.01
33%
-73
- C5 -
-
2UZV
6.9
-
KAPCA_BOVIN
A:
[34-332]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
--
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
-----
F
GNLKD
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
N
F
D
D
Y
E
--
E
E
E
I
R
V
S
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
313
Blastp_CBE
49.95
33%
-77
- C5 -
-
2UZW
6.1
-
KAPCA_BOVIN
E:
[34-332]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
--
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
-----
F
GNLKD
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
N
F
D
D
Y
E
--
E
E
E
I
R
V
S
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
316
Blastp_CBE
49.79
33%
-80
- C5 -
-
2UZT
6.7
-
KAPCA_BOVIN
A:
[34-332]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
--
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
-----
F
GNLKD
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
N
F
D
D
Y
E
--
E
E
E
I
R
V
S
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
Blastp_CBE
49.46
45%
-69
- C5 -
-
4CZU
4.6
-
CIPKN_ARATH
D:
[4-281]
-----------------
H
S
G
R
T
R
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
----
K
E
K
V
L
K
N
K
M
I
A
Q
-
I
K
R
E
I
S
T
M
K
-
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
-----
D
---
A
N
---
G
A
---
L
---
K
--
V
S
D
F
G
L
S
-
A
L
PQQV
R
---
E
D
G
----
L
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
-----
G
--
A
K
-------
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
S
--
L
Y
K
-
K
I
--
F
K
A
--
E
--
F
-
T
C
P
P
----
W
----
F
S
--
A
------
S
--
A
K
K
--
L
I
K
R
I
L
D
P
N
P
A
T
-----
R
-----
I
-----
T
F
A
E
V
I
E
N
E
W
F
K
-----
K
G
YK------------
A
P
K
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
281
Blastp_CBE
49.25
33%
-79
- C5 -
-
2F7Z
7.6
-
KAPCA_BOVIN
E:
[49-347]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
--
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
N
F
D
D
Y
E
--
E
E
E
I
R
V
S
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
315
Blastp_CBE
49.12
33%
-80
- C5 -
-
2UZU
6.0
-
KAPCA_BOVIN
E:
[34-332]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
--
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
-----
F
GNLKD
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
N
F
D
D
Y
E
--
E
E
E
I
R
V
S
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
279
Blastp_CBE
48.85
33%
-73
- C5 -
-
2OJF
6.5
-
KAPCA_BOVIN
E:
[49-347]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
--
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
N
F
D
D
Y
E
--
E
E
E
I
R
V
S
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
280
Blastp_CBE
48.79
33%
-78
- C5 -
-
2OH0
7.0
-
KAPCA_BOVIN
E:
[49-347]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
--
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
N
F
D
D
Y
E
--
E
E
E
I
R
V
S
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Blastp_CBE
48.71
45%
-64
- C5 -
-
4CZT
5.4
-
CIPKN_ARATH
D:
[4-281]
-----------------
H
S
G
R
T
R
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
----
K
E
K
V
L
K
N
K
M
I
A
Q
-
I
K
R
E
I
S
T
M
K
-
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
-----
D
---
A
N
---
G
A
---
L
---
K
--
V
S
D
F
G
L
S
-
A
L
PQQV
R
---
E
D
G
----
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
-----
G
--
A
K
-------
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
S
--
L
Y
K
-
K
I
--
F
K
A
--
E
--
F
-
T
C
P
P
----
W
----
F
S
--
A
------
S
--
A
K
K
--
L
I
K
R
I
L
D
P
N
P
A
T
-----
R
-----
I
-----
T
F
A
E
V
I
E
N
E
W
F
K
-----
K
G
YK------------
A
P
K
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
282
Blastp_CBE
48.58
33%
-70
- C5 -
-
2F7X
7.5
-
KAPCA_BOVIN
E:
[49-347]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
--
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
N
F
D
D
Y
E
--
E
E
E
I
R
V
S
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
283
Blastp_CBE
48.47
33%
-76
- C5 -
-
2F7E
7.3
-
KAPCA_BOVIN
E:
[49-347]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
--
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
N
F
D
D
Y
E
--
E
E
E
I
R
V
S
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
Blastp_CBE
48.31
45%
-75
- C5 -
-
4CZT
5.0
-
CIPKN_ARATH
C:
[10-277]
-----------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
----
K
E
K
V
L
K
N
K
M
I
A
Q
-
I
K
R
E
I
S
T
M
K
-
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
-----
D
---
A
N
---
G
A
---
L
---
K
--
V
S
D
F
G
L
S
-
A
L
PQQV
R
---
E
D
G
----
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
-----
G
--
A
K
-------
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
S
--
L
Y
K
-
K
I
--
F
K
A
--
E
--
F
-
T
C
P
P
----
W
----
F
S
--
A
------
S
--
A
K
K
--
L
I
K
R
I
L
D
P
N
P
A
T
-----
R
-----
I
-----
T
F
A
E
V
I
E
N
E
W
F
K
-----
K
G
YK------------
A
P
K
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
553
Blastp_CBE
48.27
32%
-124
- C5 -
-
4B8L
5.2
-
AUKBA_XENLA
A:
[11-270]
--------------------
K
F
T
I
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
N
K
F
I
M
A
L
K
V
L
F
----
K
S
Q
L
E
K
E
G
V
E
H
Q
-
L
R
R
E
I
E
I
Q
S
-
H
L
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
G
R
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
R
K
V
I
H
R
D
I
K
P
E
N
L
L
---
M
-----
G
---
Y
K
---
G
E
---
L
---
K
--
I
A
D
F
----------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
------
D
--
E
K
-------
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
--
T
H
R
-
R
I
--
V
N
V
--
D
--
L
-
K
F
P
P
----
F
----
L
S
--
D
------
G
--
S
K
D
--
L
I
S
K
L
L
R
Y
H
P
P
Q
-----
R
-----
L
-----
P
L
K
G
V
M
E
H
P
W
V
K
-----
A
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
490
Blastp_CBE
48.04
37%
-83
- C5 -
-
3BHH
4.9
-
KCC2B_HUMAN
A:
[6-266]
--------------------------
Y
Q
L
Y
E
D
I
G
----
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
I
N
----
T
K
K
L
S
A
R
D
H
-
Q
K
-
L
E
R
E
A
R
I
C
R
-
L
L
K
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
A
---
S
K
---
C
K
---
G
AAV
K
--
L
A
D
F
G
L
A
I
E
V
----
Q
---
G
D
Q
---
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
E
A
Y
G
-----
K
--
P
--------
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
K
--
L
Y
Q
-
Q
I
--
K
A
G
--
A
YD
F
-
P
S
P
E
----
W
DT--
V
T
--
P
------
E
--
A
K
N
--
L
I
N
Q
M
L
T
I
N
P
A
K
-----
R
-----
I
-----
T
A
H
E
A
L
K
H
P
W
V
C
-----
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
Blastp_CBE
48.00
45%
-66
- C5 -
-
4CZT
2.3
-
CIPKN_ARATH
A:
[4-279]
-----------------
H
S
G
R
T
R
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
----
K
E
K
V
L
K
N
K
M
I
A
Q
-
I
K
R
E
I
S
T
M
K
-
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
-----
D
---
A
N
---
G
A
---
L
---
K
--
V
S
D
F
G
L
S
-
A
L
PQQV
R
---
E
D
G
----
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
-----
G
--
A
K
-------
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
S
--
L
Y
K
-
K
I
--
F
K
A
--
E
--
F
-
T
C
P
P
----
W
----
F
S
--
A
------
S
--
A
K
K
--
L
I
K
R
I
L
D
P
N
P
A
T
-----
R
-----
I
-----
T
F
A
E
V
I
E
N
E
W
F
K
-----
K
G
YK------------
A
P
K
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
532
Blastp_CBE
47.91
37%
-75
- C5 -
-
6AYW
7.3
-
KCC2D_HUMAN
A:
[15-275]
--------------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
----
T
K
K
L
S
A
R
D
H
-
Q
K
-
L
E
R
E
A
R
I
C
R
-
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
A
---
S
K
---
S
K
---
G
AAV
K
--
L
A
D
F
G
L
A
I
E
V
----
Q
---
G
D
Q
---
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
-----
K
--
P
--------
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
--
L
Y
Q
-
Q
I
--
K
A
G
--
A
YD
F
-
P
S
P
E
----
W
DT--
V
T
--
P
------
E
--
A
K
D
--
L
I
N
K
M
L
T
I
N
P
A
K
-----
R
-----
I
-----
T
A
S
E
A
L
K
H
P
W
I
C
-----
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
529
Blastp_CBE
47.88
37%
-73
- C5 -
-
6BAB
8.5
-
KCC2D_MOUSE
B:
[15-275]
--------------------------
Y
Q
L
F
E
E
L
G
----
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
----
T
K
K
L
S
A
R
D
H
-
Q
K
-
L
E
R
E
A
R
I
C
R
-
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
A
---
S
K
---
S
K
---
G
AAV
K
--
L
A
D
F
G
L
A
I
E
V
----
Q
---
G
D
Q
---
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
-----
K
--
P
--------
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
--
L
Y
Q
-
Q
I
--
K
A
G
--
A
YD
F
-
P
S
P
E
----
W
DT--
V
T
--
P
------
E
--
A
K
D
--
L
I
N
K
M
L
T
I
N
P
A
K
-----
R
-----
I
-----
T
A
S
E
A
L
K
H
P
W
I
C
-----
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
531
Blastp_CBE
47.82
37%
-73
- C5 -
-
6AYW
7.7
-
KCC2D_HUMAN
B:
[15-275]
--------------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
----
T
K
K
L
S
A
R
D
H
-
Q
K
-
L
E
R
E
A
R
I
C
R
-
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
A
---
S
K
---
S
K
---
G
AAV
K
--
L
A
D
F
G
L
A
I
E
V
----
Q
---
G
D
Q
---
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
-----
K
--
P
--------
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
--
L
Y
Q
-
Q
I
--
K
A
G
--
A
YD
F
-
P
S
P
E
----
W
DT--
V
T
--
P
------
E
--
A
K
D
--
L
I
N
K
M
L
T
I
N
P
A
K
-----
R
-----
I
-----
T
A
S
E
A
L
K
H
P
W
I
C
-----
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
527
Blastp_CBE
47.65
37%
-73
- C5 -
-
6BAB
8.7
-
KCC2D_MOUSE
D:
[15-275]
--------------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
----
T
K
K
L
S
A
R
D
H
-
Q
K
-
L
E
R
E
A
R
I
C
R
-
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
A
---
S
K
---
S
K
---
G
AAV
K
--
L
A
D
F
G
L
A
I
E
V
----
Q
---
G
D
Q
---
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
-----
K
--
P
--------
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
--
L
Y
Q
-
Q
I
--
K
A
G
--
A
YD
F
-
P
S
P
E
----
W
DT--
V
T
--
P
------
E
--
A
K
D
--
L
I
N
K
M
L
T
I
N
P
A
K
-----
R
-----
I
-----
T
A
S
E
A
L
K
H
P
W
I
C
-----
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
533
Blastp_CBE
47.60
37%
-75
- C5 -
-
5VLO
9.6
-
KCC2D_HUMAN
B:
[15-275]
--------------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
----
T
K
K
L
S
A
R
D
H
-
Q
K
-
L
E
R
E
A
R
I
C
R
-
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
A
---
S
K
---
S
K
---
G
AAV
K
--
L
A
D
F
G
L
A
I
E
V
----
Q
---
G
D
Q
---
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
-----
K
--
P
--------
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
--
L
Y
Q
-
Q
I
--
K
A
G
--
A
YD
F
-
P
S
P
E
----
W
DT--
V
T
--
P
------
E
--
A
K
D
--
L
I
N
K
M
L
T
I
N
P
A
K
-----
R
-----
I
-----
T
A
S
E
A
L
K
H
P
W
I
C
-----
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
534
Blastp_CBE
47.48
37%
-78
- C5 -
-
5VLO
8.4
-
KCC2D_HUMAN
A:
[15-275]
--------------------------
Y
Q
L
F
E
E
L
G
---
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
----
T
K
K
L
S
A
R
D
H
-
Q
K
-
L
E
R
E
A
R
I
C
R
-
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
A
---
S
K
---
S
K
---
G
AAV
K
--
L
A
D
F
G
L
A
I
E
V
----
Q
---
G
D
Q
---
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
-----
K
--
P
--------
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
--
L
Y
Q
-
Q
I
--
K
A
G
--
A
YD
F
-
P
S
P
E
----
W
DT--
V
T
--
P
------
E
--
A
K
D
--
L
I
N
K
M
L
T
I
N
P
A
K
-----
R
-----
I
-----
T
A
S
E
A
L
K
H
P
W
I
C
-----
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
579
HHSearch
47.42
34%
-51
- C5 -
-
4CZT
5.3
-
CIPKN_ARATH
D:
[5-306]
------------------
S
G
R
T
R
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
----
K
E
K
V
L
K
N
K
M
I
A
Q
-
I
K
R
E
I
S
T
M
K
-
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
-----
D
---
A
N
---
G
A
---
L
---
K
--
V
S
D
F
G
L
S
-
A
L
----
P
---
Q
Q
V
RED
G
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
-----
G
--
A
K
-------
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
S
--
L
Y
K
-
K
I
--
F
K
A
--
E
--
F
-
T
C
P
P
----
W
----
F
S
--
A
------
S
--
A
K
K
--
L
I
K
R
I
L
D
P
N
P
A
T
-----
R
-----
I
-----
T
F
A
E
V
I
E
N
E
W
F
K
-----
K
G
--------------
Y
K
A
P
K
F
E
----
N
A
------
D
V
--
S
L
D
D
V
D
A
I
F
D
D
S
----
N
L
V
V
E
R
R
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
511
Blastp_CBE
46.89
37%
-72
- C5 -
-
5FG8
5.0
-
KCC2A_DROME
A:
[15-276]
-------------------------
N
Y
D
I
K
E
E
L
G
K
G
A
F
S
I
V
K
R
C
V
Q
K
S
T
G
F
E
F
A
A
K
I
I
N
----
T
K
K
L
T
A
R
D
F
-
Q
K
-
L
E
R
E
A
R
I
C
R
-
K
L
H
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
N
Y
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
F
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
N
G
V
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
A
---
S
K
---
A
K
---
G
AAV
K
--
L
A
D
F
G
L
A
I
E
V
----
Q
---
G
D
H
---
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
K
K
E
P
Y
------
G
--
K
S
-------
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
--
L
Y
S
-
Q
I
--
K
A
G
--
A
--
Y
-
D
Y
P
S
PEWD
T
----
V
T
--
P
------
E
--
A
K
N
--
L
I
N
Q
M
L
T
V
N
P
N
K
-----
R
-----
I
-----
T
A
A
E
A
L
K
H
P
W
I
C
-----
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
530
Blastp_CBE
46.50
37%
-69
- C5 -
-
6BAB
9.5
-
KCC2D_MOUSE
A:
[15-275]
--------------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
----
T
K
K
L
S
A
R
D
H
-
Q
K
-
L
E
R
E
A
R
I
C
R
-
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
A
---
S
K
---
S
K
---
G
AAV
K
--
L
A
D
F
G
L
A
I
E
V
----
Q
---
G
D
Q
---
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
-----
K
--
P
--------
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
--
L
Y
Q
-
Q
I
--
K
A
G
--
A
YD
F
-
P
S
P
E
----
W
DT--
V
T
--
P
------
E
--
A
K
D
--
L
I
N
K
M
L
T
I
N
P
A
K
-----
R
-----
I
-----
T
A
S
E
A
L
K
H
P
W
I
C
-----
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
510
Blastp_CBE
45.99
37%
-67
- C5 -
-
5H9B
5.8
-
KCC2A_DROME
A:
[15-276]
-------------------------
N
Y
D
I
K
E
E
L
G
K
G
A
F
S
I
V
K
R
C
V
Q
K
S
T
G
F
E
F
A
A
K
I
I
N
----
T
K
K
L
T
A
R
D
F
-
Q
K
-
L
E
R
E
A
R
I
C
R
-
K
L
H
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
N
Y
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
F
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
N
G
V
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
A
---
S
K
---
A
K
---
G
AAV
K
--
L
A
D
F
G
L
A
I
E
V
----
Q
---
G
D
H
---
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
K
K
E
P
Y
------
G
--
K
S
-------
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
--
L
Y
S
-
Q
I
--
K
A
G
--
A
--
Y
-
D
Y
P
S
PEWD
T
----
V
T
--
P
------
E
--
A
K
N
--
L
I
N
Q
M
L
T
V
N
P
N
K
-----
R
-----
I
-----
T
A
A
E
A
L
K
H
P
W
I
C
-----
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
528
Blastp_CBE
45.97
37%
-69
- C5 -
-
6BAB
9.4
-
KCC2D_MOUSE
C:
[15-275]
--------------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
----
Q
E
Y
A
A
K
I
I
N
----
T
K
K
L
S
A
R
D
H
-
Q
K
-
L
E
R
E
A
R
I
C
R
-
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
A
---
S
K
---
S
K
---
G
AAV
K
--
L
A
D
F
G
L
A
I
E
V
----
Q
---
G
D
Q
---
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
-----
K
--
P
--------
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
--
L
Y
Q
-
Q
I
--
K
A
G
--
A
YD
F
-
P
S
P
E
----
W
DT--
V
T
--
P
------
E
--
A
K
D
--
L
I
N
K
M
L
T
I
N
P
A
K
-----
R
-----
I
-----
T
A
S
E
A
L
K
H
P
W
I
C
-----
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
581
HHSearch
45.75
34%
-49
- C5 -
-
4CZU
3.0
-
CIPKN_ARATH
B:
[5-295]
------------------
S
G
R
T
R
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
----
K
E
K
V
L
K
N
K
M
I
A
Q
-
I
K
R
E
I
S
T
M
K
-
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
-----
D
---
A
N
---
G
A
---
L
---
K
--
V
S
D
F
G
L
S
-
A
L
----
P
---
Q
Q
V
RED
G
L
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
-----
G
--
A
K
-------
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
S
--
L
Y
K
-
K
I
--
F
K
A
--
E
--
F
-
T
C
P
P
----
W
----
F
S
--
A
------
S
--
A
K
K
--
L
I
K
R
I
L
D
P
N
P
A
T
-----
R
-----
I
-----
T
F
A
E
V
I
E
N
E
W
F
K
-----
K
G
--------------
Y
K
A
P
K
F
E
------------------
D
D
V
D
A
I
F
D
D
S
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
141
Blastp_CBE
45.21
35%
-50
- C5 -
-
3T3V
4.3
-
?
A:
[33-311]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
---
R
--
I
I
D
F
G
L
S
-
T
H
----
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
--
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
L
P
Q
----
W
KK--
V
S
--
E
------
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
--------------
T
K
---------
D
V
P
S
L
D
N
A
I
L
--
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
190
Blastp_CBE
45.14
32%
-65
- C5 -
-
5M75
5.8
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
254
Blastp_CBE
44.99
36%
-95
- C5 -
-
4NTT
4.3
-
KAPCA_MOUSE
B:
[48-297]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
175
Blastp_CBE
44.86
38%
-59
- C5 -
-
3MWU
7.5
-
?
A:
[30-302]
--------------------------------
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
----
K
A
S
A
K
N
K
D
T
-
S
T
-
I
L
R
E
V
E
L
L
K
-
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
-----
E
---
S
K
EKD
C
D
---
I
---
K
--
I
I
D
F
G
L
S
-
T
C
----
F
---
Q
Q
N
-------
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
D
--
I
L
K
-
R
V
--
E
T
G
KY
A
--
F
-
D
L
P
Q
----
W
RT--
I
S
--
D
------
D
--
A
K
D
--
L
I
R
K
M
L
T
F
H
P
S
L
-----
R
-----
I
-----
T
A
T
Q
C
L
E
H
P
W
I
Q
-----
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
150
Blastp_CBE
44.84
35%
-46
- C5 -
-
4IFG
7.8
-
?
A:
[56-336]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
---
R
--
I
I
D
F
G
L
S
-
T
H
----
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
--
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
L
P
Q
----
W
KK--
V
S
--
E
------
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
--------------
T
K
---------
D
V
P
S
L
D
N
A
I
L
--
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
184
Blastp_CBE
44.78
32%
-61
- C5 -
-
5N7P
4.6
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
140
Blastp_CBE
44.77
35%
-51
- C5 -
-
3UPX
6.4
-
?
A:
[33-319]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
---
R
--
I
I
D
F
G
L
S
-
T
H
----
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
--
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
L
P
Q
----
W
KK--
V
S
--
E
------
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
--------------
T
K
----------
V
P
S
L
D
N
A
I
L
--
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
121
Blastp_CBE
44.69
36%
-54
- C5 -
-
4IEB
4.8
-
?
A:
[56-330]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
---
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
M
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
---
R
--
I
I
D
F
G
L
S
-
T
H
----
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
--
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
-
P
Q
----
W
KK--
V
S
--
E
------
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
--------------
T
K
E
Q
I
S
V
----
D
V
P
S
L
D
N
A
I
L
--
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
183
Blastp_CBE
44.65
32%
-61
- C5 -
-
5N7U
3.5
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
163
Blastp_CBE
44.64
35%
-47
- C5 -
-
5JN2
7.1
-
?
A:
[74-356]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
---
R
--
I
I
D
F
G
L
S
-
T
H
----
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
--
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
L
P
Q
----
W
KK--
V
S
--
E
------
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
--------------
T
K
----------
V
P
S
L
D
N
A
I
L
--
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
144
Blastp_CBE
44.57
35%
-48
- C5 -
-
3SX9
5.4
-
?
A:
[33-310]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
---
R
--
I
I
D
F
G
L
S
-
T
H
----
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
--
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
L
P
Q
----
W
KK--
V
S
--
E
------
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
--------------
T
K
---------
D
V
P
S
L
D
N
A
I
L
--
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
139
Blastp_CBE
44.47
35%
-52
- C5 -
-
3UPZ
4.3
-
?
A:
[33-306]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
---
R
--
I
I
D
F
G
L
S
-
T
H
----
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
--
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
L
P
Q
----
W
KK--
V
S
--
E
------
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
--------------
T
K
----------
V
P
S
L
D
N
A
I
L
--
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
124
Blastp_CBE
44.47
35%
-48
- C5 -
-
5W9E
6.9
-
?
A:
[33-314]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
---
R
--
I
I
D
F
G
L
S
-
T
H
----
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
--
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
L
P
Q
----
W
KK--
V
S
--
E
------
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
--------------
T
K
---------
D
V
P
S
L
D
N
A
I
L
--
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
412
Blastp_CBE
44.37
32%
-62
- C5 -
-
5OTG
4.9
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
446
Blastp_CBE
44.43
32%
-61
- C5 -
-
5N1H
3.8
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
155
Blastp_CBE
44.42
35%
-53
- C5 -
-
3HX4
4.9
-
?
A:
[57-330]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
-------
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
---
R
--
I
I
D
F
G
L
S
-
T
H
----
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
--
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
L
P
Q
----
W
KK--
V
S
--
E
------
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
--------------
T
K
E
Q
I
S
V
----
D
V
P
S
L
D
N
A
I
L
--
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
162
Blastp_CBE
44.40
35%
-51
- C5 -
-
5T6A
7.0
-
?
A:
[74-371]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
---
R
--
I
I
D
F
G
L
S
-
T
H
----
F
---
E
A
----
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
--
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
L
P
Q
----
W
KK--
V
S
--
E
------
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
--------------
T
K
-----------
P
S
L
D
N
A
I
L
--
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
192
Blastp_CBE
44.37
32%
-62
- C5 -
-
5M6Y
5.5
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
160
Blastp_CBE
44.38
35%
-58
- C5 -
-
5T6K
1.9
-
?
A:
[74-369]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
---
R
--
I
I
D
F
G
L
S
-
T
H
----
F
---
E
A
----
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
--
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
L
P
Q
----
W
KK--
V
S
--
E
------
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
---------------------------
P
S
L
D
N
A
I
L
--
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
135
Blastp_CBE
44.37
35%
-48
- C5 -
-
4JBV
6.7
-
?
A:
[33-306]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
---
R
--
I
I
D
F
G
L
S
-
T
H
----
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
--
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
L
P
Q
----
W
KK--
V
S
--
E
------
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
--------------
T
K
---------
D
V
P
S
L
D
N
A
I
L
--
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
132
Blastp_CBE
44.36
35%
-46
- C5 -
-
4TZR
5.9
-
?
A:
[33-306]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
---
R
--
I
I
D
F
G
L
S
-
T
H
----
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
--
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
L
P
Q
----
W
KK--
V
S
--
E
------
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
--------------
T
K
---------
D
V
P
S
L
D
N
A
I
L
--
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
188
Blastp_CBE
44.35
32%
-62
- C5 -
-
5N1D
4.5
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
193
Blastp_CBE
44.33
32%
-61
- C5 -
-
5M6V
6.4
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
151
Blastp_CBE
44.30
35%
-48
- C5 -
-
3KU2
4.6
-
?
A:
[56-336]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
---
R
--
I
I
D
F
G
L
S
-
T
H
----
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
--
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
L
P
Q
----
W
KK--
V
S
--
E
------
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
--------------
T
K
E
Q
I
S
V
----
D
V
P
S
L
D
N
A
I
L
--
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
428
Blastp_CBE
44.28
32%
-61
- C5 -
-
5N3J
4.4
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
407
Blastp_CBE
44.18
32%
-72
- C5 -
-
6EH2
5.1
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
---
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
------
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
--
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
148
Blastp_CBE
44.24
35%
-48
- C5 -
-
4IHP
6.5
-
?
A:
[56-337]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
---
R
--
I
I
D
F
G
L
S
-
T
H
----
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
--
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
L
P
Q
----
W
KK--
V
S
--
E
------
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
--------------
T
K
E
Q
I
S
------
V
P
S
L
D
N
A
I
L
--
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
127
Blastp_CBE
44.24
35%
-50
- C5 -
-
5W80
6.9
-
?
A:
[33-313]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
---
R
--
I
I
D
F
G
L
S
-
T
H
----
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
--
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
L
P
Q
----
W
KK--
V
S
--
E
------
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
--------------
T
K
----
V
----
D
V
P
S
L
D
N
A
I
L
--
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
125
Blastp_CBE
44.24
35%
-52
- C5 -
-
5W91
6.6
-
?
A:
[33-314]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
---
R
--
I
I
D
F
G
L
S
-
T
H
----
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
--
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
L
P
Q
----
W
KK--
V
S
--
E
------
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
--------------
T
K
----------
V
P
S
L
D
N
A
I
L
--
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
199
Blastp_CBE
44.23
32%
-63
- C5 -
-
5LCT
5.2
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
433
Blastp_CBE
44.21
32%
-59
- C5 -
-
5N3E
3.4
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
432
Blastp_CBE
44.19
32%
-69
- C5 -
-
5N3F
3.6
-
KAPCA_CRIGR
A:
[41-336]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
--
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
-
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
164
Blastp_CBE
44.18
35%
-50
- C5 -
-
5JMS
6.3
-
?
A:
[74-358]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
---
R
--
I
I
D
F
G
L
S
-
T
H
----
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
--
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
L
P
Q
----
W
KK--
V
S
--
E
------
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
--------------
T
K
----------
V
P
S
L
D
N
A
I
L
--
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
225
Blastp_CBE
44.16
36%
-83
- C5 -
-
6MM7
2.7
-
KAPCA_MOUSE
D:
[37-298]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
128
Blastp_CBE
44.16
35%
-45
- C5 -
-
4YJN
4.3
-
?
A:
[33-306]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
---
R
--
I
I
D
F
G
L
S
-
T
H
----
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
--
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
L
P
Q
----
W
KK--
V
S
--
E
------
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
--------------
T
K
E
---------
V
P
S
L
D
N
A
I
L
--
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
438
Blastp_CBE
44.15
32%
-57
- C5 -
-
5N39
4.7
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
131
Blastp_CBE
44.13
35%
-50
- C5 -
-
4WG3
7.5
-
?
A:
[33-306]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
---
R
--
I
I
D
F
G
L
S
-
T
H
----
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
--
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
L
P
Q
----
W
KK--
V
S
--
E
------
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
--------------
T
K
---------
D
V
P
S
L
D
N
A
I
L
--
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
126
Blastp_CBE
44.10
35%
-44
- C5 -
-
5W8R
7.2
-
?
A:
[33-312]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
---
R
--
I
I
D
F
G
L
S
-
T
H
----
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
--
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
L
P
Q
----
W
KK--
V
S
--
E
------
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
--------------
T
K
E
Q
--
V
----
D
V
P
S
L
D
N
A
I
L
--
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
198
Blastp_CBE
44.09
32%
-65
- C5 -
-
5LCU
5.3
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
149
Blastp_CBE
44.07
35%
-48
- C5 -
-
4IH8
5.8
-
?
A:
[56-350]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
-----SKD
A
N
---
I
---
R
--
I
I
D
F
G
L
S
-
T
H
----
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
--
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
L
P
Q
----
W
KK--
V
S
--
E
------
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
--------------
T
-----------
V
P
S
L
D
N
A
I
L
--
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
356
Blastp_CBE
43.99
36%
-89
- C5 -
-
3DND
4.2
-
KAPCA_BOVIN
A:
[48-297]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
-----
F
GNLKD
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
187
Blastp_CBE
44.03
32%
-59
- C5 -
-
5N1E
3.9
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
415
Blastp_CBE
43.96
32%
-62
- C5 -
-
5OK3
6.3
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
173
Blastp_CBE
43.99
38%
-54
- C5 -
-
4Y5Q
5.0
-
?
A:
[30-302]
--------------------------------
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
----
K
A
S
A
K
N
K
D
T
-
S
T
-
I
L
R
E
V
E
L
L
K
-
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
-----
E
---
S
K
EKD
C
D
---
I
---
K
--
I
I
D
F
G
L
S
-
T
C
----
F
---
Q
Q
N
---
T
---
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
D
--
I
L
K
-
R
V
--
E
T
G
KY
A
--
F
-
D
L
P
Q
----
W
RT--
I
S
--
D
------
D
--
A
K
D
--
L
I
R
K
M
L
T
F
H
P
S
L
-----
R
-----
I
-----
T
A
T
Q
C
L
E
H
P
W
I
Q
-----
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
153
Blastp_CBE
43.99
35%
-44
- C5 -
-
4MXA
5.3
-
?
A:
[34-313]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
Y
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
---
R
--
I
I
D
F
G
L
S
-
T
H
----
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
--
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
L
P
Q
----
W
KK--
V
S
--
E
------
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
--------------
T
K
E
Q
I
S
V
----
D
V
P
S
L
D
N
A
I
L
--
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
205
Blastp_CBE
43.96
36%
-87
- C5 -
-
5UZK
9.2
-
KAPCA_HUMAN
A:
[49-298]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
441
Blastp_CBE
43.97
32%
-61
- C5 -
-
5N33
3.6
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
189
Blastp_CBE
43.96
32%
-58
- C5 -
-
5MHI
3.4
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
174
Blastp_CBE
43.94
38%
-61
- C5 -
-
3NCG
7.3
-
?
A:
[30-319]
--------------------------------
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
----
K
A
S
A
K
N
K
D
T
-
S
T
-
I
L
R
E
V
E
L
L
K
-
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
-----
E
---
S
K
EKD
C
D
---
I
---
K
--
I
I
D
F
G
L
S
-
T
C
----
F
---
Q
Q
N
---
T
-----
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
D
--
I
L
K
-
R
V
--
E
T
G
KY
A
--
F
-
D
L
P
Q
----
W
RT--
I
S
--
D
------
D
--
A
K
D
--
L
I
R
K
M
L
T
F
H
P
S
L
-----
R
-----
I
-----
T
A
T
Q
C
L
E
H
P
W
I
Q
-----
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
136
Blastp_CBE
43.94
35%
-47
- C5 -
-
3V5T
6.7
-
?
A:
[33-306]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
---
R
--
I
I
D
F
G
L
S
-
T
H
----
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
--
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
L
P
Q
----
W
KK--
V
S
--
E
------
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
--------------
T
K
---------
D
V
P
S
L
D
N
A
I
L
--
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
448
Blastp_CBE
43.86
32%
-62
- C5 -
-
5N1F
5.0
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
437
Blastp_CBE
43.85
32%
-58
- C5 -
-
5N3A
3.9
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
202
Blastp_CBE
43.92
32%
-64
- C5 -
-
5LCP
5.9
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
416
Blastp_CBE
43.85
32%
-63
- C5 -
-
5O5M
6.3
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
------
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
439
Blastp_CBE
43.90
32%
-60
* C5 *
-
5N37
4.9
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
434
Blastp_CBE
43.86
32%
-58
- C5 -
-
5N3D
3.8
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
181
Blastp_CBE
43.85
35%
-93
- C5 -
-
6F14
4.6
-
KAPCA_CRIGR
A:
[39-298]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
----
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
394
Blastp_CBE
43.78
32%
-65
- C5 -
-
6I2B
6.1
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
------
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
422
Blastp_CBE
43.76
32%
-61
- C5 -
-
5N3Q
3.6
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
295
Blastp_CBE
43.82
37%
-86
- C5 -
-
4BDB
3.5
-
CHK2_HUMAN
A:
[17-287]
-------------------------
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
---------
L
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
---
K
--
I
T
D
F
G
H
S
-
K
I
----
L
----
E
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
--
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
E
----
V
WAE-
V
S
--
E
------
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
391
Blastp_CBE
43.81
32%
-63
- C5 -
-
6I2H
5.6
-
?
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
406
Blastp_CBE
43.79
32%
-62
- C5 -
-
6EH3
5.3
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
237
Blastp_CBE
43.78
33%
-65
- C5 -
-
1REK
10.6
-
KAPCA_MOUSE
A:
[48-346]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
191
Blastp_CBE
43.76
32%
-65
- C5 -
-
5M71
5.2
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
123
Blastp_CBE
43.76
35%
-48
- C5 -
-
5W9R
7.1
-
?
A:
[33-320]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
---
R
--
I
I
D
F
G
L
S
-
T
H
----
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
--
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
L
P
Q
----
W
KK--
V
S
--
E
------
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
--------------
T
K
---------
D
V
P
S
L
D
N
A
I
L
--
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
413
Blastp_CBE
43.74
32%
-59
- C5 -
-
5OT3
6.1
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
130
Blastp_CBE
43.73
35%
-45
- C5 -
-
4WG4
7.4
-
?
A:
[33-312]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
---
R
--
I
I
D
F
G
L
S
-
T
H
----
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
--
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
L
P
Q
----
W
KK--
V
S
--
E
------
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
--------------
T
K
---------
D
V
P
S
L
D
N
A
I
L
--
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
417
Blastp_CBE
43.72
32%
-62
- C5 -
-
5O0E
6.5
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
197
Blastp_CBE
43.71
32%
-60
- C5 -
-
5M0B
5.0
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
420
Blastp_CBE
43.69
32%
-60
- C5 -
-
5N3S
3.6
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
221
Blastp_CBE
43.67
36%
-86
- C5 -
-
3L9L
7.9
-
KAPCA_HUMAN
A:
[49-298]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
440
Blastp_CBE
43.65
32%
-58
- C5 -
-
5N36
3.3
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
392
Blastp_CBE
43.61
32%
-55
- C5 -
-
6I2D
6.1
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
507
Blastp_CBE
43.51
31%
-81
- C5 -
-
4B8M
7.3
-
AUKBA_XENLA
A:
[11-281]
--------------------
K
F
T
I
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
N
K
F
I
M
A
L
K
V
L
F
----
K
S
Q
L
E
K
E
G
V
E
H
Q
-
L
R
R
E
I
E
I
Q
S
-
H
L
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
G
R
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
R
K
V
I
H
R
D
I
K
P
E
N
L
L
---
M
-----
G
---
Y
K
---
G
E
---
L
---
K
--
I
A
D
F
G
W
S
-------
V
---
H
A
P
---
S
L
R
R
R
M
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
------
D
--
E
K
-------
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
--
T
H
R
-
R
I
--
V
N
V
--
D
--
L
-
K
F
P
P
----
F
----
L
S
--
D
------
G
--
S
K
D
--
L
I
S
K
L
L
R
Y
H
P
P
Q
-----
R
-----
L
-----
P
L
K
G
V
M
E
H
P
W
V
K
-----
A
N
--------------
S
R
R
V
L
-------
P
P
V
Y
Q
S
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
514
Blastp_CBE
43.50
36%
-57
- C5 -
-
4YZB
5.7
-
?
A:
[38-310]
--------------------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
V
T
G
Q
E
Y
A
V
K
V
I
S
----
K
R
---
Q
K
T
D
K
E
L
-
L
L
K
E
V
E
L
L
K
-
K
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
NKR
K
D
---
A
N
---
I
---
R
--
I
I
D
F
G
L
S
-
T
H
----
F
---
E
S
T
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
F
D
--
I
L
K
-
K
V
--
E
K
G
KF
T
--
F
-
D
L
P
Q
----
W
----
K
K
--
V
------
S
EP
A
K
D
--
L
I
R
K
M
L
A
Y
V
P
T
M
-----
R
-----
I
-----
S
A
R
D
A
L
E
H
E
W
L
K
-----
T
------------------
T
D
S
I
----
D
V
P
S
L
E
S
T
I
L
--
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
442
Blastp_CBE
43.59
32%
-62
- C5 -
-
5N1O
4.8
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
-
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
404
Blastp_CBE
43.52
32%
-59
- C5 -
-
6EM6
6.1
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
401
Blastp_CBE
43.52
32%
-55
- C5 -
-
6EMD
6.0
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
410
Blastp_CBE
43.58
32%
-62
- C5 -
-
5OUC
4.9
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
196
Blastp_CBE
43.57
32%
-60
- C5 -
-
5M0C
4.3
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
396
Blastp_CBE
43.50
32%
-60
- C5 -
-
6ESA
6.4
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
390
Blastp_CBE
43.50
32%
-60
- C5 -
-
6EM7
7.8
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
388
Blastp_CBE
43.48
35%
-91
- C5 -
-
5NW8
5.2
-
KAPCA_CRIGR
A:
[39-298]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
424
Blastp_CBE
43.46
32%
-56
- C5 -
-
5N3O
4.1
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
447
Blastp_CBE
43.45
32%
-59
- C5 -
-
5N1G
4.0
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
219
Blastp_CBE
43.52
36%
-87
- C5 -
-
3OOG
4.3
-
KAPCA_HUMAN
A:
[49-298]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
200
Blastp_CBE
43.51
32%
-62
- C5 -
-
5LCR
5.3
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
261
Blastp_CBE
43.50
37%
-81
- C5 -
-
2YCQ
7.7
-
CHK2_HUMAN
A:
[11-281]
-------------------------
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
----------
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
---
K
--
I
T
D
F
G
H
S
-
K
I
----
L
---
G
E
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
--
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
E
----
V
WAE-
V
S
--
E
------
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
488
Blastp_CBE
43.39
36%
-88
- C5 -
-
4DFX
7.2
-
KAPCA_MOUSE
E:
[48-297]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
304
Blastp_CBE
43.44
37%
-77
- C5 -
-
2WTJ
3.6
-
CHK2_HUMAN
A:
[17-287]
-------------------------
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
-------
P
A
L
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
---
K
--
I
T
D
F
G
H
S
-
K
I
----
L
----
E
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
--
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
E
----
V
WAE-
V
S
--
E
------
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
201
Blastp_CBE
43.47
32%
-60
- C5 -
-
5LCQ
5.6
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
309
Blastp_CBE
43.43
37%
-79
- C5 -
-
2CN5
6.4
-
CHK2_HUMAN
A:
[17-287]
-------------------------
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
R
---------
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
---
K
--
I
T
D
F
G
H
S
-
K
I
----
L
---
G
E
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
--
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
E
----
V
WAE-
V
S
--
E
------
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
260
Blastp_CBE
43.46
37%
-86
- C5 -
-
2YCS
6.6
-
CHK2_HUMAN
A:
[11-281]
-------------------------
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
----------
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
---
K
--
I
T
D
F
G
H
S
-
K
I
----
L
-----
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
--
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
E
----
V
WAE-
V
S
--
E
------
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
227
Blastp_CBE
43.45
36%
-89
- C5 -
-
6MM6
3.1
-
KAPCA_MOUSE
E:
[37-299]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
257
Blastp_CBE
43.44
37%
-83
- C5 -
-
2YIT
7.5
-
CHK2_HUMAN
A:
[11-281]
-------------------------
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
---------
L
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
---
K
--
I
T
D
F
G
H
S
-
K
I
----
L
---
G
E
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
--
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
E
----
V
WAE-
V
S
--
E
------
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
303
Blastp_CBE
43.43
37%
-79
- C5 -
-
2XBJ
7.3
-
CHK2_HUMAN
A:
[17-287]
-------------------------
E
Y
I
M
S
K
T
L
G
S
G
A
-
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
--------
A
L
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
---
K
--
I
T
D
F
G
H
S
-
K
I
----
L
-----
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
--
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
E
----
V
WAE-
V
S
--
E
------
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
405
Blastp_CBE
43.42
32%
-61
- C5 -
-
6EM2
5.2
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
445
Blastp_CBE
43.41
32%
-57
- C5 -
-
5N1L
5.2
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
486
Blastp_CBE
43.32
36%
-86
- C5 -
-
4X6R
7.4
-
KAPCA_MOUSE
A:
[48-297]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
431
Blastp_CBE
43.32
32%
-62
- C5 -
-
5N3G
4.1
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
299
Blastp_CBE
43.39
37%
-87
- C5 -
-
4A9S
5.0
-
CHK2_HUMAN
A:
[17-287]
-------------------------
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
-------
P
A
L
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
---
K
--
I
T
D
F
G
H
S
-
K
I
----
L
-----
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
--
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
E
----
V
WAE-
V
S
--
E
------
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
287
Blastp_CBE
43.36
37%
-83
- C5 -
-
4BDJ
5.3
-
CHK2_HUMAN
A:
[17-287]
-------------------------
E
Y
I
M
S
K
T
L
-----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
----------
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
---
K
--
I
T
D
F
G
H
S
-
K
I
----
L
----
E
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
--
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
E
----
V
WAE-
V
S
--
E
------
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
266
Blastp_CBE
43.37
36%
-93
- C5 -
-
1YDS
4.5
-
KAPCA_BOVIN
E:
[48-297]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
-----
F
GNLKD
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
334
Blastp_CBE
43.33
36%
-86
- C5 -
-
3L9M
6.6
-
KAPCA_HUMAN
A:
[49-298]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
K
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
220
Blastp_CBE
43.36
36%
-90
- C5 -
-
3L9L
7.8
-
KAPCA_HUMAN
B:
[49-298]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
301
Blastp_CBE
43.32
37%
-79
- C5 -
-
2XM9
7.8
-
CHK2_HUMAN
A:
[17-287]
-------------------------
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
-------
P
A
L
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
---
K
--
I
T
D
F
G
H
S
-
K
I
----
L
---
G
E
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
--
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
E
----
V
WAE-
V
S
--
E
------
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
355
Blastp_CBE
43.29
36%
-88
- C5 -
-
3DNE
4.9
-
KAPCA_BOVIN
A:
[48-297]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
-----
F
GNLKD
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
305
Blastp_CBE
43.33
37%
-76
- C5 -
-
2WTI
6.4
-
CHK2_HUMAN
A:
[17-287]
-------------------------
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
-------
P
A
L
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
---
K
--
I
T
D
F
G
H
S
-
K
I
----
L
----
E
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
--
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
E
----
V
WAE-
V
S
--
E
------
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
255
Blastp_CBE
43.32
36%
-96
- C5 -
-
4NTT
4.8
-
KAPCA_MOUSE
A:
[48-297]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
408
Blastp_CBE
43.31
32%
-57
- C5 -
-
6EGW
6.3
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
---
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
-----
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
143
Blastp_CBE
43.30
35%
-45
- C5 -
-
3SXF
7.6
-
?
A:
[33-317]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
---
R
--
I
I
D
F
G
L
S
-
T
H
----
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
--
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
L
P
Q
----
W
KK--
V
S
--
E
------
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
--------------
T
K
E
Q
I
S
V
----
D
V
P
S
L
D
N
A
I
L
--
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
120
Blastp_CBE
43.29
37%
-60
- C5 -
-
3MA6
4.1
-
?
A:
[39-292]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
---
R
--
I
I
D
F
G
L
S
-
T
H
----
F
---
E
-
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
--
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
L
P
Q
----
W
KK--
V
S
--
E
------
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
513
Blastp_CBE
43.28
36%
-56
- C5 -
-
4YZB
6.1
-
?
B:
[38-310]
--------------------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
V
T
G
Q
E
Y
A
V
K
V
I
S
----
K
R
---
Q
K
T
D
K
E
L
-
L
L
K
E
V
E
L
L
K
-
K
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
NKR
K
D
---
A
N
---
I
---
R
--
I
I
D
F
G
L
S
-
T
H
----
F
---
E
S
T
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
F
D
--
I
L
K
-
K
V
--
E
K
G
KF
T
--
F
-
D
L
P
Q
----
W
----
K
K
--
V
------
S
EP
A
K
D
--
L
I
R
K
M
L
A
Y
V
P
T
M
-----
R
-----
I
-----
S
A
R
D
A
L
E
H
E
W
L
K
-----
T
--------------------
S
I
----
D
V
P
S
L
E
S
T
I
L
--
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
399
Blastp_CBE
43.21
32%
-57
- C5 -
-
6ERT
5.5
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
154
Blastp_CBE
43.24
35%
-44
- C5 -
-
4MX9
5.1
-
?
A:
[34-313]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
Y
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
---
R
--
I
I
D
F
G
L
S
-
T
H
----
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
--
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
L
P
Q
----
W
KK--
V
S
--
E
------
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
--------------
T
K
E
Q
I
S
V
----
D
V
P
S
L
D
N
A
I
L
--
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
133
Blastp_CBE
43.24
35%
-48
- C5 -
-
4ONA
6.3
-
?
A:
[33-306]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
---
R
--
I
I
D
F
G
L
S
-
T
H
----
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
--
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
L
P
Q
----
W
KK--
V
S
--
E
------
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
--------------
T
K
E
Q
I
S
V
----
D
V
P
S
L
D
N
A
I
L
--
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
403
Blastp_CBE
43.16
32%
-59
- C5 -
-
6EMA
5.6
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
402
Blastp_CBE
43.16
32%
-62
- C5 -
-
6EMB
6.1
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
395
Blastp_CBE
43.21
32%
-62
- C5 -
-
6I2A
6.2
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
393
Blastp_CBE
43.15
32%
-59
- C5 -
-
6I2C
5.9
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
--
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
286
Blastp_CBE
43.20
37%
-79
- C5 -
-
4BDK
3.7
-
CHK2_HUMAN
A:
[17-287]
-------------------------
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
--------
A
L
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
---
K
--
I
T
D
F
G
H
S
-
K
I
----
L
---
G
E
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
--
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
E
----
V
WAE-
V
S
--
E
------
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
216
Blastp_CBE
43.17
36%
-87
- C5 -
-
3OXT
5.8
-
KAPCA_HUMAN
A:
[49-298]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
426
Blastp_CBE
43.11
32%
-59
- C5 -
-
5N3L
4.5
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
436
Blastp_CBE
43.18
32%
-58
- C5 -
-
5N3B
3.2
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
176
Blastp_CBE
43.17
38%
-57
- C5 -
-
3IGO
5.7
-
?
A:
[30-297]
--------------------------------
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
----
K
A
S
A
K
N
K
-
T
-
S
T
-
I
L
R
E
V
E
L
L
K
-
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
-----
E
---
S
K
EKD
C
D
---
I
---
K
--
I
I
D
F
G
L
S
-
T
C
----
F
---
Q
Q
N
---
T
-------
T
A
Y
Y
I
A
P
E
V
L
R
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
D
--
I
L
K
-
R
V
--
E
T
G
KY
A
--
F
-
D
L
P
Q
----
W
RT--
I
S
--
D
------
D
--
A
K
D
--
L
I
R
K
M
L
T
F
H
P
S
L
-----
R
-----
I
-----
T
A
T
Q
C
L
E
H
P
W
I
Q
-----
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
397
Blastp_CBE
43.10
32%
-64
- C5 -
-
6ERW
5.7
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
---
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
195
Blastp_CBE
43.15
32%
-59
- C5 -
-
5M0L
4.3
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
435
Blastp_CBE
43.04
32%
-57
- C5 -
-
5N3C
3.7
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
423
Blastp_CBE
43.04
32%
-59
- C5 -
-
5N3P
4.2
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
414
Blastp_CBE
43.11
32%
-57
- C5 -
-
5OL3
6.4
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
353
Blastp_CBE
43.10
36%
-91
- C5 -
-
4YXS
5.2
-
KAPCA_BOVIN
A:
[48-297]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
-----
F
GNLKD
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134
Blastp_CBE
43.09
35%
-46
- C5 -
-
4M84
4.1
-
?
A:
[33-306]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
---
R
--
I
I
D
F
G
L
S
-
T
H
----
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
--
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
L
P
Q
----
W
KK--
V
S
--
E
------
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
--------------
T
K
E
Q
I
S
V
----
D
V
P
S
L
D
N
A
I
L
--
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
297
Blastp_CBE
43.03
37%
-77
- C5 -
-
4A9U
6.5
-
CHK2_HUMAN
A:
[17-287]
-------------------------
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
------
D
P
A
L
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
---
K
--
I
T
D
F
G
H
S
-
K
I
----
L
-----
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
--
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
E
----
V
WAE-
V
S
--
E
------
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
213
Blastp_CBE
43.04
36%
-88
- C5 -
-
4UJ1
5.9
-
KAPCA_HUMAN
A:
[49-298]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
269
Blastp_CBE
43.03
36%
-86
- C5 -
-
1JBP
6.1
-
KAPCA_MOUSE
E:
[48-297]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
E
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
210
Blastp_CBE
43.05
36%
-85
- C5 -
-
4UJA
7.1
-
KAPCA_HUMAN
A:
[49-298]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
185
Blastp_CBE
43.04
32%
-61
- C5 -
-
5N32
4.9
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
-
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
142
Blastp_CBE
43.03
35%
-45
- C5 -
-
3T3U
6.1
-
?
A:
[33-317]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
---
R
--
I
I
D
F
G
L
S
-
T
H
----
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
--
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
L
P
Q
----
W
KK--
V
S
--
E
------
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
--------------
T
K
E
Q
I
S
V
----
D
V
P
S
L
D
N
A
I
L
--
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
263
Blastp_CBE
43.00
37%
-86
- C5 -
-
2W0J
6.0
-
CHK2_HUMAN
A:
[11-282]
-------------------------
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
----------
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
---
K
--
I
T
D
F
G
H
S
-
K
I
----
L
-----
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
--
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
E
----
V
WAE-
V
S
--
E
------
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
400
Blastp_CBE
42.99
32%
-59
- C5 -
-
6ERS
5.9
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
--
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
262
Blastp_CBE
42.96
37%
-78
- C5 -
-
2W7X
7.2
-
CHK2_HUMAN
A:
[11-281]
-------------------------
E
Y
I
M
S
K
T
L
G
S
G
A
-
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
----------
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
---
K
--
I
T
D
F
G
H
S
-
K
I
----
L
---
G
E
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
--
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
E
----
V
WAE-
V
S
--
E
------
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
112
Blastp_CBE
42.97
36%
-78
- C5 -
-
2JC6
5.4
-
KCC1D_HUMAN
A:
[12-283]
-----
S
W
K
K
Q
A
E
D
I
K
K
I
F
E
F
K
---------
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
P
----
K
K
A
-------
S
S
-
I
E
N
E
I
A
V
L
R
-
K
I
K
H
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
---
Y
YSQ--
D
---
E
E
---
S
K
---
I
---
M
--
I
S
-------------------------------
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
-----
K
--
A
--------
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
S
K
--
L
F
E
-
Q
I
--
L
K
A
EY
E
--
F
-
D
S
P
Y
----
W
DD--
I
S
--
D
------
S
--
A
K
D
--
F
I
R
N
L
M
E
K
D
P
N
K
-----
R
-----
Y
-----
T
C
E
Q
A
A
R
H
P
W
I
A
-----
G
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
186
Blastp_CBE
42.96
32%
-56
- C5 -
-
5N1K
3.7
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
-
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
273
Blastp_CBE
42.94
33%
-77
- C5 -
-
5VI9
6.8
-
KAPCA_BOVIN
A:
[49-347]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
------------------------------
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
292
Blastp_CBE
42.87
37%
-88
- C5 -
-
4BDE
4.3
-
CHK2_HUMAN
A:
[17-287]
-------------------------
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
--------
A
L
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
---
K
--
I
T
D
F
G
H
S
-
K
I
----
L
-----
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
--
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
E
----
V
WAE-
V
S
--
E
------
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
430
Blastp_CBE
42.86
32%
-58
- C5 -
-
5N3H
3.4
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
270
Blastp_CBE
42.83
37%
-76
- C5 -
-
2XK9
7.3
-
CHK2_HUMAN
A:
[10-280]
-------------------------
E
Y
I
M
S
K
T
L
G
S
G
A
-
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
----------
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
---
K
--
I
T
D
F
G
H
S
-
K
I
----
L
---
G
E
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
--
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
E
----
V
WAE-
V
S
--
E
------
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
119
Blastp_CBE
42.85
37%
-52
- C5 -
-
3MA6
5.6
-
?
B:
[39-292]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
-
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
---
R
--
I
I
D
F
G
L
S
-
T
H
----
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
--
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
L
P
Q
----
W
KK--
V
S
--
E
------
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
274
Blastp_CBE
42.84
37%
-77
- C5 -
-
2YCF
6.7
-
CHK2_HUMAN
A:
[11-281]
-------------------------
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
----------
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
---
K
--
I
T
D
F
G
H
S
-
K
I
----
L
---
G
E
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
--
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
E
----
V
WAE-
V
S
--
E
------
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
161
Blastp_CBE
42.83
35%
-61
- C5 -
-
5T6I
6.5
-
?
A:
[74-374]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
--
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SK-
A
N
---
I
---
R
--
I
I
D
F
G
L
S
-
T
H
----
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
--
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
L
P
Q
----
W
KK--
V
S
--
E
------
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
--------------
T
-----------
V
P
S
L
D
N
A
I
L
--
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
366
Blastp_CBE
42.78
33%
-68
- C5 -
-
3AMB
7.4
-
KAPCA_HUMAN
A:
[49-347]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
Q
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
K
--
V
A
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
----------
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
444
Blastp_CBE
42.73
32%
-58
- C5 -
-
5N1M
3.6
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
224
Blastp_CBE
42.80
36%
-88
- C5 -
-
6MM8
3.1
-
KAPCA_MOUSE
C:
[37-297]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
288
Blastp_CBE
42.79
37%
-75
- C5 -
-
4BDI
3.0
-
CHK2_HUMAN
A:
[17-287]
-------------------------
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
--------
A
L
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
---
K
--
I
T
D
F
G
H
S
-
K
I
----
L
---
G
E
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
--
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
E
----
V
WAE-
V
S
--
E
------
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
293
Blastp_CBE
42.76
37%
-89
- C5 -
-
4BDD
4.8
-
CHK2_HUMAN
A:
[17-287]
-------------------------
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
----------
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
---
K
--
I
T
D
F
G
H
S
-
K
I
----
L
-----
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
--
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
E
----
V
WAE-
V
S
--
E
------
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
145
Blastp_CBE
42.78
35%
-45
- C5 -
-
3N51
7.3
-
?
A:
[33-321]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
---
R
--
I
I
D
F
G
L
S
-
T
H
----
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
--
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
L
P
Q
----
W
KK--
V
S
--
E
------
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
--------------
T
K
E
Q
I
S
V
----
D
V
P
S
L
D
N
A
I
L
--
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
306
Blastp_CBE
42.77
37%
-81
- C5 -
-
2WTD
6.2
-
CHK2_HUMAN
A:
[17-287]
-------------------------
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
-------
P
A
L
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
---
K
--
I
T
D
F
G
H
S
-
K
I
----
L
-----
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
--
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
E
----
V
WAE-
V
S
--
E
------
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
456
Blastp_CBE
42.68
33%
-59
- C5 -
-
4HPU
6.7
-
KAPCA_MOUSE
E:
[48-346]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
222
Blastp_CBE
42.76
36%
-84
- C5 -
-
3AGM
7.2
-
KAPCA_HUMAN
A:
[49-298]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
249
Blastp_CBE
42.73
36%
-82
- C5 -
-
3AGL
8.5
-
KAPCA_HUMAN
A:
[49-298]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
321
Blastp_CBE
42.71
33%
-73
- C5 -
-
3AG9
8.2
-
KAPCA_BOVIN
B:
[49-347]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
------------------------
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
146
Blastp_CBE
42.74
35%
-43
- C5 -
-
3I7B
7.3
-
?
A:
[33-309]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
---
R
--
I
I
D
F
G
L
S
-
T
H
----
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
--
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
L
P
Q
----
W
KK--
V
S
--
E
------
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
--------------
T
K
E
Q
I
S
V
----
D
V
P
S
L
D
N
A
I
L
--
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
122
Blastp_CBE
42.73
35%
-42
- C5 -
-
6BFA
5.6
-
?
A:
[33-306]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
---
R
--
I
I
D
F
G
L
S
-
T
H
----
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
--
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
L
P
Q
----
W
KK--
V
S
--
E
------
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
--------------
T
K
E
Q
I
S
V
----
D
V
P
S
L
D
N
A
I
L
--
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
152
Blastp_CBE
42.71
38%
-54
- C5 -
-
2WEI
6.7
-
?
A:
[30-282]
--------------------------------
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
----
K
A
S
A
K
N
K
D
T
-
S
T
-
I
L
R
E
V
E
L
L
K
-
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
-----
E
---
S
K
EKD
C
D
---
I
---
K
--
I
I
D
F
G
L
S
-
T
C
----
F
---
Q
Q
N
---
T
K
M
K
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
D
--
I
L
K
-
R
V
--
E
T
G
KY
A
--
F
-
D
L
P
Q
----
W
RT--
I
S
--
D
------
D
--
A
K
D
--
L
I
R
K
M
L
T
F
H
P
S
L
-----
R
-----
I
-----
T
A
T
Q
C
L
E
H
P
W
I
Q
-----
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
496
Blastp_CBE
42.70
36%
-78
- C5 -
-
4WB7
9.0
-
KAPCA_HUMAN
B:
[103-352]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
384
Blastp_CBE
42.64
36%
-90
- C5 -
-
2JDV
7.2
-
KAPCA_BOVIN
A:
[49-298]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
K
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
332
Blastp_CBE
42.65
36%
-88
- C5 -
-
3L9N
6.3
-
KAPCA_HUMAN
A:
[49-301]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
K
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
307
Blastp_CBE
42.68
37%
-79
- C5 -
-
2WTC
5.8
-
CHK2_HUMAN
A:
[17-287]
-------------------------
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
-------
P
A
L
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
---
K
--
I
T
D
F
G
H
S
-
K
I
----
L
-----
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
--
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
E
----
V
WAE-
V
S
--
E
------
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
291
Blastp_CBE
42.65
37%
-75
- C5 -
-
4BDF
4.8
-
CHK2_HUMAN
A:
[17-287]
-------------------------
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
----------
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
---
K
--
I
T
D
F
G
H
S
-
K
I
----
L
---
G
E
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
--
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
E
----
V
WAE-
V
S
--
E
------
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
238
Blastp_CBE
42.67
33%
-57
- C5 -
-
1REJ
6.4
-
KAPCA_MOUSE
A:
[48-346]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
268
Blastp_CBE
42.66
37%
-81
- C5 -
-
2YCR
6.5
-
CHK2_HUMAN
A:
[11-281]
-------------------------
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
----------
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
---
K
--
I
T
D
F
G
H
S
-
K
I
----
L
---
G
E
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
--
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
E
----
V
WAE-
V
S
--
E
------
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
265
Blastp_CBE
42.65
36%
-89
- C5 -
-
1YDT
6.8
-
KAPCA_BOVIN
E:
[48-297]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
-----
F
GNLKD
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
354
Blastp_CBE
42.64
36%
-86
- C5 -
-
4YXR
4.1
-
KAPCA_BOVIN
A:
[48-297]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
-----
F
GNLKD
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
308
Blastp_CBE
42.60
37%
-83
- C5 -
-
2CN8
5.2
-
CHK2_HUMAN
A:
[17-287]
-------------------------
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
----------
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
---
K
--
I
T
D
F
G
H
S
-
K
I
----
L
-----
T
---
S
L
M
R
T
L
C
--
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
---
V
--
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
E
----
V
WAE-
V
S
--
E
------
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
485
Blastp_CBE
42.62
36%
-85
- C5 -
-
4WB8
8.8
-
KAPCA_HUMAN
A:
[35-284]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
264
Blastp_CBE
42.59
33%
-55
- C5 -
-
6C0U
7.6
-
KAPCA_HUMAN
A:
[52-350]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
290
Blastp_CBE
42.58
37%
-78
- C5 -
-
4BDG
3.9
-
CHK2_HUMAN
A:
[17-287]
-------------------------
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
----------
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
---
K
--
I
T
D
F
G
H
S
-
K
I
----
L
---
G
E
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
--
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
E
----
V
WAE-
V
S
--
E
------
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
272
Blastp_CBE
42.60
33%
-73
- C5 -
-
5VIB
8.0
-
KAPCA_BOVIN
A:
[49-351]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
-------------
F
D
D
Y
E
--
E
E
E
I
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
245
Blastp_CBE
42.59
36%
-83
- C5 -
-
5BX6
4.4
-
KAPCA_HUMAN
A:
[49-298]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
214
Blastp_CBE
42.58
36%
-85
- C5 -
-
3POO
7.0
-
KAPCA_HUMAN
A:
[49-302]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
234
Blastp_CBE
42.54
33%
-61
- C5 -
-
3IDC
6.2
-
KAPCA_MOUSE
A:
[48-346]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
171
Blastp_CBE
42.53
33%
-57
- C5 -
-
1CDK
8.5
-
KAPCA_PIG
A:
[48-346]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
F
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
Y
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
-----
F
GNLKD
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
N
F
D
D
Y
E
--
E
E
E
I
R
V
S
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
376
Blastp_CBE
42.48
33%
-56
- C5 -
-
1RDQ
7.8
-
KAPCA_MOUSE
E:
[48-346]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
A
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
492
Blastp_CBE
42.42
36%
-86
- C5 -
-
4O21
6.3
-
KAPCA_MOUSE
A:
[40-289]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
298
Blastp_CBE
42.48
37%
-69
- C5 -
-
4A9T
6.5
-
CHK2_HUMAN
A:
[17-287]
-------------------------
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
-------
P
A
L
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
---
K
--
I
T
D
F
G
H
S
-
K
I
----
L
---
G
E
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
--
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
E
----
V
WAE-
V
S
--
E
------
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
537
Blastp_CBE
42.37
35%
-69
- C5 -
-
4FTU
7.2
-
CHK1_HUMAN
A:
[10-270]
----------------------------
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
----
M
----------
N
-
I
K
K
E
I
C
I
N
K
-
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
-----
D
---
E
R
---
D
N
---
L
---
K
--
I
S
D
F
G
L
A
-
T
V
----
F
RYN
N
R
E
---
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
--
E
P
-------
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
---
P
S
--
D
S
C
-
Q
E
--
Y
S
D
--
W
--
K
-
E
K
K
T
----
Y
----
L
N
--
P
WKKIDS
A
--
P
L
A
--
L
L
H
K
I
L
V
E
N
P
S
A
-----
R
-----
I
-----
T
I
P
D
I
K
K
D
R
W
Y
N
-----
K
P
--------------
L
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
371
Blastp_CBE
42.47
36%
-89
- C5 -
-
4Z84
6.2
-
KAPCA_BOVIN
A:
[49-298]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
K
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
480
Blastp_CBE
42.46
33%
-58
- C5 -
-
4IAK
6.5
-
KAPCA_MOUSE
A:
[54-352]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
357
Blastp_CBE
42.40
35%
-86
- C5 -
-
3QAL
8.1
-
KAPCA_MOUSE
E:
[48-297]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
AFGNL
K
-----
N
-----
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
218
Blastp_CBE
42.44
36%
-84
- C5 -
-
3OVV
6.5
-
KAPCA_HUMAN
A:
[49-298]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
385
Blastp_CBE
42.42
36%
-84
- C5 -
-
2JDT
6.3
-
KAPCA_BOVIN
A:
[49-298]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
K
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
178
Blastp_CBE
42.40
34%
-61
- C5 -
-
2GNL
5.6
-
KAPCA_BOVIN
A:
[48-346]
-------------------------------
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
K
--
V
A
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
235
Blastp_CBE
42.39
33%
-57
- C5 -
-
3IDB
6.1
-
KAPCA_MOUSE
A:
[48-346]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
194
Blastp_CBE
42.38
32%
-60
- C5 -
-
5M0U
Error
-
KAPCA_CRIGR
A:
[41-349]
---------------------
A
Q
L
D
H
F
D
R
I
K
T
L
G
----
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
239
Blastp_CBE
42.37
33%
-55
- C5 -
-
1RE8
8.2
-
KAPCA_MOUSE
A:
[48-346]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
383
Blastp_CBE
42.30
36%
-87
- C5 -
-
2UVX
4.0
-
KAPCA_BOVIN
A:
[49-298]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
K
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
251
Blastp_CBE
42.35
33%
-56
- C5 -
-
1BX6
6.5
-
KAPCA_MOUSE
A:
[48-346]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
Blastp_CBE
42.33
36%
-70
- C5 -
-
6T6F
5.6
-
?
B:
[5-290]
------
W
K
K
Q
A
E
D
I
K
K
I
F
E
F
K
---------
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
P
----
K
K
A
L
K
G
K
E
--
S
S
-
I
E
N
E
I
A
V
L
R
-
K
I
K
H
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
---
Y
YSQ--
D
---
E
E
---
S
K
---
I
---
M
--
I
S
D
F
G
----------------------------
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
-----
K
--
A
--------
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
S
K
--
L
F
E
-
Q
I
--
L
K
A
EY
E
--
F
-
D
S
P
Y
----
W
DD--
I
S
--
D
------
S
--
A
K
D
--
F
I
R
N
L
M
E
K
D
P
N
K
-----
R
-----
Y
-----
T
C
E
Q
A
A
R
H
P
W
I
A
-----
G
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
547
Blastp_CBE
42.32
35%
-64
- C5 -
-
4FT7
6.8
-
CHK1_HUMAN
A:
[10-270]
----------------------------
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
----
M
----------
N
-
I
K
K
E
I
C
I
N
K
-
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
-----
D
---
E
R
---
D
N
---
L
---
K
--
I
S
D
F
G
L
A
-
T
V
----
F
RYN
N
R
E
---
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
--
E
P
-------
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
---
P
S
--
D
S
C
-
Q
E
--
Y
S
D
--
W
--
K
-
E
K
K
T
----
Y
----
L
N
--
P
WKKIDS
A
--
P
L
A
--
L
L
H
K
I
L
V
E
N
P
S
A
-----
R
-----
I
-----
T
I
P
D
I
K
K
D
R
W
Y
N
-----
K
P
--------------
L
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
247
Blastp_CBE
42.30
36%
-84
- C5 -
-
3VQH
7.0
-
KAPCA_HUMAN
A:
[49-298]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
472
Blastp_CBE
42.28
33%
-59
- C5 -
-
4XW6
6.7
-
KAPCA_MOUSE
A:
[54-352]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
324
Blastp_CBE
42.27
33%
-59
- C5 -
-
2C1A
6.6
-
KAPCA_BOVIN
A:
[49-347]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
498
Blastp_CBE
42.17
33%
-66
- C5 -
-
5VHB
7.6
-
KAPCA_BOVIN
A:
[49-347]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
---------
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
523
Blastp_CBE
42.25
33%
-69
- C5 -
-
6FRX
7.6
-
KAPCA_HUMAN
A:
[49-347]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
Q
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
K
--
V
A
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
----------
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
250
Blastp_CBE
42.24
36%
-87
- C5 -
-
2GU8
7.1
-
KAPCA_HUMAN
A:
[35-284]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
E
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
504
Blastp_CBE
42.14
33%
-54
- C5 -
-
1XH4
9.2
-
KAPCA_BOVIN
A:
[48-346]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
470
Blastp_CBE
42.14
36%
-82
- C5 -
-
1L3R
6.6
-
KAPCA_MOUSE
E:
[48-297]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
367
Blastp_CBE
42.14
33%
-71
- C5 -
-
3AMA
6.8
-
KAPCA_HUMAN
A:
[49-347]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
Q
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
K
--
V
A
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
----------
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
331
Blastp_CBE
42.17
36%
-87
- C5 -
-
1XH9
8.9
-
KAPCA_BOVIN
A:
[48-297]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
E
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
K
--
V
T
D
F
G
L
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
466
Blastp_CBE
42.15
33%
-55
- C5 -
-
3X2W
7.0
-
KAPCA_MOUSE
A:
[55-353]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
333
Blastp_CBE
42.14
36%
-86
- C5 -
-
3L9M
6.8
-
KAPCA_HUMAN
B:
[49-298]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
K
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
170
Blastp_CBE
42.13
33%
-54
- C5 -
-
1CDK
8.4
-
KAPCA_PIG
B:
[48-346]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
F
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
Y
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
-----
F
GNLKD
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
N
F
D
D
Y
E
--
E
E
E
I
R
V
S
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129
Blastp_CBE
42.13
35%
-45
- C5 -
-
4WG5
8.3
-
?
A:
[33-306]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
---
R
--
I
I
D
F
G
L
S
-
T
H
----
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
--
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
L
P
Q
----
W
KK--
V
S
--
E
------
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
--------------
T
K
E
Q
I
S
V
----
D
V
P
S
L
D
N
A
I
L
--
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
258
Blastp_CBE
42.12
37%
-79
- C5 -
-
2YIR
7.3
-
CHK2_HUMAN
A:
[11-281]
-------------------------
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
---------
L
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
---
K
--
I
T
D
F
G
H
S
-
K
I
----
L
---
G
E
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
--
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
E
----
V
WAE-
V
S
--
E
------
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
259
Blastp_CBE
42.10
37%
-79
- C5 -
-
2YIQ
7.4
-
CHK2_HUMAN
A:
[11-281]
-------------------------
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
------------
V
E
T
E
I
E
I
L
K
-
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
---
K
--
I
T
D
F
G
H
S
-
K
I
----
L
---
G
E
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
--
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
E
----
V
WAE-
V
S
--
E
------
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
469
Blastp_CBE
42.11
36%
-81
- C5 -
-
3TNQ
5.0
-
KAPCA_MOUSE
B:
[48-297]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
215
Blastp_CBE
42.10
36%
-86
- C5 -
-
3P0M
6.3
-
KAPCA_HUMAN
A:
[49-298]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
550
Blastp_CBE
41.88
35%
-65
- C5 -
-
4FSR
7.8
-
CHK1_HUMAN
A:
[10-270]
----------------------------
L
V
Q
T
L
G
E
G
--
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
----
M
K
---------
N
-
I
K
K
E
I
C
I
N
K
-
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
-----
D
---
E
R
---
D
N
---
L
---
K
--
I
S
D
F
G
L
A
-
T
V
----
F
RYN
N
R
E
---
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
--
E
P
-------
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
---
P
S
--
D
S
C
-
Q
E
--
Y
S
D
--
W
--
K
-
E
K
K
T
----
Y
----
L
N
--
P
WKKIDS
A
--
P
L
A
--
L
L
H
K
I
L
V
E
N
P
S
A
-----
R
-----
I
-----
T
I
P
D
I
K
K
D
R
W
Y
N
-----
K
P
--------------
L
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
508
Blastp_CBE
42.09
33%
-53
- C5 -
-
1XH7
9.9
-
KAPCA_BOVIN
A:
[48-346]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
477
Blastp_CBE
42.00
33%
-51
- C5 -
-
4IB0
7.0
-
KAPCA_MOUSE
A:
[54-352]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
212
Blastp_CBE
42.08
36%
-84
- C5 -
-
4UJ2
6.5
-
KAPCA_HUMAN
A:
[49-298]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
328
Blastp_CBE
42.03
33%
-58
- C5 -
-
1XH6
9.7
-
KAPCA_BOVIN
A:
[48-346]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
294
Blastp_CBE
42.06
37%
-83
- C5 -
-
4BDC
3.2
-
CHK2_HUMAN
A:
[17-287]
-------------------------
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
----------
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
---
K
--
I
T
D
F
G
H
S
-
K
I
----
L
----
E
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
--
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
E
----
V
WAE-
V
S
--
E
------
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
476
Blastp_CBE
41.97
33%
-57
- C5 -
-
4IB1
7.1
-
KAPCA_MOUSE
A:
[54-352]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
289
Blastp_CBE
42.03
37%
-82
- C5 -
-
4BDH
3.7
-
CHK2_HUMAN
A:
[17-287]
-------------------------
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
----------
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
---
K
--
I
T
D
F
G
H
S
-
K
I
----
L
---
G
E
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
--
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
E
----
V
WAE-
V
S
--
E
------
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
267
Blastp_CBE
42.05
36%
-89
- C5 -
-
1YDR
5.1
-
KAPCA_BOVIN
E:
[48-297]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
-----
F
GNLKD
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
177
Blastp_CBE
42.04
33%
-59
- C5 -
-
2QUR
5.1
-
KAPCA_MOUSE
A:
[48-346]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLP
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
A
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
516
Blastp_CBE
41.93
36%
-50
- C5 -
-
4YUQ
5.8
-
?
A:
[38-310]
--------------------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
V
T
G
Q
E
Y
A
V
K
V
I
S
----
K
R
Q
--------
L
-
L
L
K
E
V
E
L
L
K
-
K
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
NKR
K
D
---
A
N
---
I
---
R
--
I
I
D
F
G
L
S
-
T
H
----
F
---
E
S
T
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
F
D
--
I
L
K
-
K
V
--
E
K
G
KF
T
--
F
-
D
L
P
Q
----
W
----
K
K
--
V
------
S
EP
A
K
D
--
L
I
R
K
M
L
A
Y
V
P
T
M
-----
R
-----
I
-----
S
A
R
D
A
L
E
H
E
W
L
K
-----
T
T
--------------
D
---
D
S
I
----
D
V
P
S
L
E
S
T
I
L
--
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
230
Blastp_CBE
42.03
33%
-56
- C5 -
-
4HPT
5.8
-
KAPCA_MOUSE
E:
[48-346]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
455
Blastp_CBE
42.01
33%
-55
- C5 -
-
4WBB
5.8
-
KAPCA_MOUSE
B:
[48-346]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
364
Blastp_CBE
42.00
33%
-56
- C5 -
-
4Z83
6.9
-
KAPCA_BOVIN
E:
[48-346]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
K
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
368
Blastp_CBE
41.99
33%
-56
- C5 -
-
3QAM
7.8
-
KAPCA_MOUSE
E:
[48-346]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
A
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
479
Blastp_CBE
41.90
33%
-58
- C5 -
-
4IAY
6.6
-
KAPCA_MOUSE
A:
[54-352]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
546
Blastp_CBE
41.87
35%
-65
- C5 -
-
4FT9
6.1
-
CHK1_HUMAN
A:
[10-270]
----------------------------
L
V
Q
T
L
G
E
G
--
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
----
M
---------
E
N
-
I
K
K
E
I
C
I
N
K
-
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
-----
D
---
E
R
---
D
N
---
L
---
K
--
I
S
D
F
G
L
A
-
T
V
----
F
RYN
N
R
E
---
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
--
E
P
-------
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
---
P
S
--
D
S
C
-
Q
E
--
Y
S
D
--
W
--
K
-
E
K
K
T
----
Y
----
L
N
--
P
WKKIDS
A
--
P
L
A
--
L
L
H
K
I
L
V
E
N
P
S
A
-----
R
-----
I
-----
T
I
P
D
I
K
K
D
R
W
Y
N
-----
K
P
--------------
L
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
473
Blastp_CBE
41.97
33%
-57
- C5 -
-
4XW5
7.0
-
KAPCA_MOUSE
A:
[54-352]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
483
Blastp_CBE
41.95
33%
-55
- C5 -
-
4IAD
6.7
-
KAPCA_MOUSE
A:
[54-352]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
545
Blastp_CBE
41.83
35%
-66
- C5 -
-
4FTI
8.4
-
CHK1_HUMAN
A:
[10-270]
----------------------------
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
----
M
---------
E
N
-
I
K
K
E
I
C
I
N
K
-
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
-----
D
---
E
R
---
D
N
---
L
---
K
--
I
S
D
F
G
L
A
-
T
V
----
F
RYN
N
R
E
---
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
--
E
P
-------
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
---
P
S
--
D
S
C
-
Q
E
--
Y
S
D
--
W
--
K
-
E
K
K
T
----
Y
----
L
N
--
P
WKKIDS
A
--
P
L
A
--
L
L
H
K
I
L
V
E
N
P
S
A
-----
R
-----
I
-----
T
I
P
D
I
K
K
D
R
W
Y
N
-----
K
P
--------------
L
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
484
Blastp_CBE
41.93
33%
-54
- C5 -
-
4IAC
6.3
-
KAPCA_MOUSE
A:
[54-352]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
503
Blastp_CBE
41.83
33%
-56
- C5 -
-
3BWJ
9.3
-
KAPCA_BOVIN
A:
[48-346]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
310
Blastp_CBE
41.91
33%
-57
- C5 -
-
3MVJ
4.8
-
KAPCA_HUMAN
E:
[69-367]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
464
Blastp_CBE
41.90
33%
-54
- C5 -
-
2QCS
8.8
-
KAPCA_MOUSE
A:
[48-346]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
241
Blastp_CBE
41.87
33%
-59
- C5 -
-
1FMO
5.2
-
KAPCA_MOUSE
E:
[48-346]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
111
Blastp_CBE
41.88
36%
-74
- C5 -
-
2JC6
5.5
-
KCC1D_HUMAN
C:
[12-283]
-----
S
W
K
K
Q
A
E
D
I
K
K
I
F
E
F
K
---------
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
P
----
K
K
A
--------
S
-
I
E
N
E
I
A
V
L
R
-
K
I
K
H
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
---
Y
YSQ--
D
---
E
E
---
S
K
---
I
---
M
--
I
S
-------------------------------
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
-----
K
--
A
--------
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
S
K
--
L
F
E
-
Q
I
--
L
K
A
EY
E
--
F
-
D
S
P
Y
----
W
DD--
I
S
--
D
------
S
--
A
K
D
--
F
I
R
N
L
M
E
K
D
P
N
K
-----
R
-----
Y
-----
T
C
E
Q
A
A
R
H
P
W
I
A
-----
G
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110
Blastp_CBE
41.87
36%
-66
- C5 -
-
6T6F
5.6
-
?
A:
[5-290]
------
W
K
K
Q
A
E
D
I
K
K
I
F
E
F
K
---------
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
P
----
K
K
A
L
K
G
K
E
--
S
S
-
I
E
N
E
I
A
V
L
R
-
K
I
K
H
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
---
Y
YSQ--
D
---
E
E
---
S
K
---
I
---
M
--
I
S
D
F
G
L
S
--------------------------
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
-----
K
--
A
--------
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
S
K
--
L
F
E
-
Q
I
--
L
K
A
EY
E
--
F
-
D
S
P
Y
----
W
DD--
I
S
--
D
------
S
--
A
K
D
--
F
I
R
N
L
M
E
K
D
P
N
K
-----
R
-----
Y
-----
T
C
E
Q
A
A
R
H
P
W
I
A
-----
G
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
380
Blastp_CBE
41.82
36%
-84
- C5 -
-
4AXA
6.8
-
KAPCA_BOVIN
A:
[49-298]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
K
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
370
Blastp_CBE
41.82
36%
-86
- C5 -
-
1SMH
3.1
-
KAPCA_BOVIN
A:
[48-297]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
E
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
L
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
525
Blastp_CBE
41.85
33%
-98
- C5 -
-
4PDS
3.7
-
RAD53_YEAST
B:
[28-306]
---------------------------
I
I
D
E
V
---
G
A
F
A
T
V
K
K
A
I
E
R
T
T
G
K
T
F
S
V
K
I
I
------------------
V
T
R
E
L
E
V
L
Q
-
K
L
N
H
P
R
I
V
R
L
K
G
F
Y
-----
Y
Y
M
V
M
E
F
V
S
G
G
D
L
M
D
F
V
A
A
H
G
A
V
G
E
D
A
G
R
E
I
S
R
Q
I
L
T
A
I
K
Y
I
H
S
M
G
I
S
H
R
D
L
K
P
D
N
I
L
---
I
EQ---
D
---
D
P
---
V
L
---
V
---
K
--
I
T
A
F
G
L
A
-
K
V
----------------------
T
L
A
Y
V
A
P
E
V
I
----------------NEYSSL-
V
D
M
W
S
M
G
C
L
V
Y
V
I
L
T
G
H
L
P
F
S
G
S
T
Q
D
Q
--
L
Y
K
-
Q
I
--
G
R
G
--
S
--
Y
-
H
E
G
P
----
L
KDFR
I
S
--
E
------
E
--
A
R
D
--
F
I
D
S
L
L
Q
V
D
P
N
N
-----
R
-----
S
-----
T
A
A
K
A
L
N
H
P
W
I
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
300
Blastp_CBE
41.83
37%
-76
- C5 -
-
4A9R
3.8
-
CHK2_HUMAN
A:
[17-287]
-------------------------
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
-------
P
A
L
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
---
K
--
I
T
D
F
G
H
S
-
K
I
----
L
---
G
E
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
--
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
E
----
V
WAE-
V
S
--
E
------
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
114
Blastp_CBE
41.82
38%
-78
- C5 -
-
4FG7
4.5
-
KCC1A_HUMAN
A:
[20-277]
--------------------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
---------------
S
-
M
E
N
E
I
A
V
L
H
-
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
-----
D
---
E
D
---
S
K
---
I
---
M
--
I
S
D
F
G
L
S
-
K
M
----
E
---
D
P
-----------
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
--
S
--------
K
A
-------
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
--
L
F
E
-
Q
I
--
L
K
A
EY
E
--
F
-
D
S
P
Y
----
W
DD--
I
S
--
D
------
S
--
A
K
D
--
F
I
R
H
L
M
E
K
D
P
E
K
-----
R
-----
F
-----
T
C
E
Q
A
L
Q
H
P
W
I
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
451
Blastp_CBE
41.81
36%
-86
- C5 -
-
4WB5
8.6
-
KAPCA_HUMAN
A:
[48-297]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
349
Blastp_CBE
41.75
33%
-55
- C5 -
-
1SVE
7.9
-
KAPCA_BOVIN
A:
[48-346]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
377
Blastp_CBE
41.78
36%
-83
- C5 -
-
2VO0
7.0
-
KAPCA_BOVIN
A:
[49-298]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
K
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
252
Blastp_CBE
41.77
33%
-60
- C5 -
-
1BKX
5.1
-
KAPCA_MOUSE
A:
[48-346]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
115
Blastp_CBE
41.76
38%
-70
- C5 -
-
4FG8
4.2
-
KCC1A_HUMAN
B:
[20-279]
--------------------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
----
K
--------------
N
E
I
A
V
L
H
-
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
-----
D
---
E
D
---
S
K
---
I
---
M
--
I
S
D
F
G
---------------
G
---
S
V
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
--------
K
A
-------
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
--
L
F
E
-
Q
I
--
L
K
A
EY
E
--
F
-
D
S
P
Y
----
W
DD--
I
S
--
D
------
S
--
A
K
D
--
F
I
R
H
L
M
E
K
D
P
E
K
-----
R
-----
F
-----
T
C
E
Q
A
L
Q
H
P
W
I
A
-----
G
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
348
Blastp_CBE
41.75
33%
-57
- C5 -
-
1SVG
8.6
-
KAPCA_BOVIN
A:
[48-346]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
248
Blastp_CBE
41.73
36%
-81
- C5 -
-
3AGL
8.5
-
KAPCA_HUMAN
B:
[49-298]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
217
Blastp_CBE
41.71
36%
-82
- C5 -
-
3OWP
5.9
-
KAPCA_HUMAN
A:
[49-298]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
505
Blastp_CBE
41.60
33%
-57
- C5 -
-
1Q8W
5.2
-
KAPCA_BOVIN
A:
[48-346]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
375
Blastp_CBE
41.69
33%
-55
- C5 -
-
3FHI
8.2
-
KAPCA_MOUSE
A:
[48-346]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
A
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
501
Blastp_CBE
41.58
33%
-57
- C5 -
-
2JDS
7.5
-
KAPCA_BOVIN
A:
[49-347]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
465
Blastp_CBE
41.67
36%
-83
- C5 -
-
3PVB
6.7
-
KAPCA_MOUSE
A:
[43-292]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
471
Blastp_CBE
41.65
33%
-54
- C5 -
-
6E21
7.7
-
KAPCA_MOUSE
A:
[54-352]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
520
Blastp_CBE
41.53
36%
-52
- C5 -
-
4YSJ
6.1
-
?
A:
[38-310]
--------------------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
V
T
G
Q
E
Y
A
V
K
V
I
S
----
K
R
-----------
L
L
K
E
V
E
L
L
K
-
K
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
NKR
K
D
---
A
N
---
I
---
R
--
I
I
D
F
G
L
S
-
T
H
----
F
---
E
S
T
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
F
D
--
I
L
K
-
K
V
--
E
K
G
KF
T
--
F
-
D
L
P
Q
----
W
----
K
K
--
V
------
S
EP
A
K
D
--
L
I
R
K
M
L
A
Y
V
P
T
M
-----
R
-----
I
-----
S
A
R
D
A
L
E
H
E
W
L
K
-----
T
T
-------------------
S
I
----
D
V
P
S
L
E
S
T
I
L
--
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
536
Blastp_CBE
41.51
35%
-63
- C5 -
-
4FSN
7.8
-
CHK1_HUMAN
A:
[9-269]
----------------------------
L
V
Q
T
L
G
E
G
A
-
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
----
M
---------
E
N
-
I
K
K
E
I
C
I
N
K
-
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
-----
D
---
E
R
---
D
N
---
L
---
K
--
I
S
D
F
G
L
A
-
T
V
----
F
RYN
N
R
E
---
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
--
E
P
-------
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
---
P
S
--
D
S
C
-
Q
E
--
Y
S
D
--
W
--
K
-
E
K
K
T
----
Y
----
L
N
--
P
WKKIDS
A
--
P
L
A
--
L
L
H
K
I
L
V
E
N
P
S
A
-----
R
-----
I
-----
T
I
P
D
I
K
K
D
R
W
Y
N
-----
K
P
--------------
L
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
468
Blastp_CBE
41.60
33%
-54
- C5 -
-
3X2U
6.4
-
KAPCA_MOUSE
A:
[55-353]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
463
Blastp_CBE
41.51
33%
-59
- C5 -
-
4DG0
7.0
-
KAPCA_MOUSE
E:
[48-346]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
497
Blastp_CBE
41.59
36%
-77
- C5 -
-
4WB7
9.0
-
DNJB1_HUMAN (first)
A:
[103-352]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
323
Blastp_CBE
41.58
33%
-57
- C5 -
-
2C1B
6.7
-
KAPCA_BOVIN
A:
[49-347]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
232
Blastp_CBE
41.57
33%
-55
- C5 -
-
3OW3
4.7
-
KAPCA_MOUSE
A:
[48-346]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
493
Blastp_CBE
41.56
36%
-81
- C5 -
-
3NX8
3.5
-
KAPCA_HUMAN
A:
[49-298]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
N
-
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
482
Blastp_CBE
41.53
33%
-56
- C5 -
-
4IAF
6.8
-
KAPCA_MOUSE
A:
[54-352]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
296
Blastp_CBE
41.51
37%
-79
- C5 -
-
4BDA
4.7
-
CHK2_HUMAN
A:
[17-287]
-------------------------
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
----------
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
---
K
--
I
T
D
F
G
H
S
-
K
I
----
L
----
E
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
--
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
E
----
V
WAE-
V
S
--
E
------
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
351
Blastp_CBE
41.50
33%
-56
- C5 -
-
1Q8U
6.0
-
KAPCA_BOVIN
A:
[48-346]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
382
Blastp_CBE
41.49
36%
-80
- C5 -
-
2UW4
3.6
-
KAPCA_BOVIN
A:
[49-298]
-------------------------------
T
L
G
T
G
S
-
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
K
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
467
Blastp_CBE
41.48
33%
-56
- C5 -
-
3X2V
7.0
-
KAPCA_MOUSE
A:
[55-353]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
242
Blastp_CBE
41.47
33%
-56
- C5 -
-
1ATP
8.6
-
KAPCA_MOUSE
E:
[48-346]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
460
Blastp_CBE
41.46
33%
-55
- C5 -
-
4DH3
8.2
-
KAPCA_MOUSE
A:
[48-346]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
325
Blastp_CBE
41.45
33%
-58
- C5 -
-
4IJ9
6.8
-
KAPCA_BOVIN
A:
[48-346]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
478
Blastp_CBE
41.36
33%
-54
- C5 -
-
4IAZ
6.8
-
KAPCA_MOUSE
A:
[54-352]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
474
Blastp_CBE
41.44
33%
-53
- C5 -
-
4XW4
6.4
-
KAPCA_MOUSE
A:
[54-352]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
329
Blastp_CBE
41.43
33%
-54
- C5 -
-
1XH5
9.3
-
KAPCA_BOVIN
A:
[48-346]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
500
Blastp_CBE
41.33
33%
-59
- C5 -
-
3ZO1
6.0
-
KAPCA_BOVIN
A:
[49-347]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
330
Blastp_CBE
41.41
33%
-54
- C5 -
-
1SVH
8.5
-
KAPCA_BOVIN
A:
[48-346]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
475
Blastp_CBE
41.39
33%
-54
- C5 -
-
4IB3
6.6
-
KAPCA_MOUSE
A:
[54-352]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
113
Blastp_CBE
41.38
38%
-62
- C5 -
-
3F3Z
5.7
-
?
A:
[10-269]
-------------------------
Y
Y
T
L
E
N
T
I
G
R
G
S
W
G
E
V
K
I
A
V
Q
K
G
T
R
I
R
R
A
A
K
K
I
P
----
K
Y
F
V
E
D
V
D
---
R
-
F
K
Q
E
I
E
I
M
K
-
S
L
D
H
P
N
I
I
R
L
Y
E
T
F
E
D
N
T
D
I
Y
L
V
M
E
L
C
T
G
G
E
L
F
E
R
V
V
H
K
R
V
F
R
E
S
D
A
A
R
I
M
K
D
V
L
S
A
V
A
Y
C
H
K
L
N
V
A
H
R
D
L
K
P
E
N
F
L
---
F
LTD--
S
---
P
D
---
S
P
---
L
---
K
--
L
I
D
F
G
L
A
-
A
R
----
F
---
K
P
G
---
K
M
M
R
T
K
V
G
T
P
Y
Y
V
S
P
Q
V
L
E
G
-
L
Y
------
G
--
P
E
-------
C
D
E
W
S
A
G
V
M
M
Y
V
L
L
C
G
Y
P
P
F
S
---
A
P
T
DE
V
M
L
-
K
I
--
R
E
G
--
T
--
F
-
T
F
P
E
KD--
W
----
L
N
VS
P
------
Q
--
A
E
S
--
L
I
R
R
L
L
T
K
S
P
K
Q
-----
R
-----
I
-----
T
S
L
Q
A
L
E
H
E
W
F
E
-----
K
Q
--------------
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
236
Blastp_CBE
41.36
33%
-55
- C5 -
-
3FJQ
9.0
-
KAPCA_MOUSE
E:
[48-346]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
548
Blastp_CBE
41.25
35%
-67
- C5 -
-
4FT5
6.5
-
CHK1_HUMAN
A:
[10-270]
----------------------------
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
----
M
----------
N
-
I
K
K
E
I
C
I
N
K
-
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
-----
D
---
E
R
---
D
N
---
L
---
K
--
I
S
D
F
G
L
A
-
T
V
----
F
RYN
N
R
E
---
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
--
E
P
-------
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
---
P
S
--
D
S
C
-
Q
E
--
Y
S
D
--
W
--
K
-
E
K
K
T
----
Y
----
L
N
--
P
WKKIDS
A
--
P
L
A
--
L
L
H
K
I
L
V
E
N
P
S
A
-----
R
-----
I
-----
T
I
P
D
I
K
K
D
R
W
Y
N
-----
K
P
--------------
L
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
231
Blastp_CBE
41.34
33%
-56
- C5 -
-
4DIN
7.3
-
KAPCA_MOUSE
A:
[48-346]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
481
Blastp_CBE
41.33
33%
-55
- C5 -
-
4IAI
7.4
-
KAPCA_MOUSE
A:
[54-352]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
369
Blastp_CBE
41.32
36%
-81
- C5 -
-
1XHA
8.7
-
KAPCA_BOVIN
A:
[48-297]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
E
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
L
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
362
Blastp_CBE
41.31
33%
-56
- C5 -
-
2GNH
5.9
-
KAPCA_BOVIN
A:
[48-346]
-------------------------------
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
K
--
V
A
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
386
Blastp_CBE
41.24
33%
-46
- C5 -
-
4WB6
8.5
-
KAPCA_HUMAN
A:
[48-346]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
R
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
N
F
D
D
Y
E
--
E
E
E
I
R
V
S
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
458
Blastp_CBE
41.29
33%
-56
- C5 -
-
4DH7
8.0
-
KAPCA_MOUSE
A:
[48-346]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
352
Blastp_CBE
41.23
33%
-55
- C5 -
-
1Q8T
4.7
-
KAPCA_BOVIN
A:
[48-346]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
361
Blastp_CBE
41.27
33%
-52
- C5 -
-
2GNI
5.3
-
KAPCA_BOVIN
A:
[48-346]
-------------------------------
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
K
--
V
A
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
327
Blastp_CBE
41.26
33%
-54
- C5 -
-
1XH8
10.9
-
KAPCA_BOVIN
A:
[48-346]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
459
Blastp_CBE
41.25
33%
-52
- C5 -
-
4DH5
6.8
-
KAPCA_MOUSE
A:
[48-346]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
322
Blastp_CBE
41.24
33%
-59
- C5 -
-
2VO7
8.0
-
KAPCA_BOVIN
A:
[49-347]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
381
Blastp_CBE
41.13
36%
-80
- C5 -
-
2UW7
5.7
-
KAPCA_BOVIN
A:
[49-298]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
K
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
350
Blastp_CBE
41.23
33%
-58
- C5 -
-
1STC
8.5
-
KAPCA_BOVIN
E:
[48-346]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
243
Blastp_CBE
41.20
33%
-53
- C5 -
-
2ERZ
5.2
-
KAPCA_MOUSE
E:
[49-347]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
347
Blastp_CBE
41.16
33%
-54
- C5 -
-
1VEB
8.0
-
KAPCA_BOVIN
A:
[48-346]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
179
Blastp_CBE
41.18
34%
-52
- C5 -
-
2GNJ
5.4
-
KAPCA_BOVIN
A:
[48-346]
-------------------------------
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
K
--
V
A
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
544
Blastp_CBE
41.17
35%
-68
- C5 -
-
4FTJ
6.7
-
CHK1_HUMAN
A:
[10-270]
----------------------------
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
------------------
I
K
K
E
I
C
I
N
K
-
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
-----
D
---
E
R
---
D
N
---
L
---
K
--
I
S
D
F
G
L
A
-
T
V
----
F
RYN
N
R
E
---
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
--
E
P
-------
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
---
P
S
--
D
S
C
-
Q
E
--
Y
S
D
--
W
--
K
-
E
K
K
T
----
Y
----
L
N
--
P
WKKIDS
A
--
P
L
A
--
L
L
H
K
I
L
V
E
N
P
S
A
-----
R
-----
I
-----
T
I
P
D
I
K
K
D
R
W
Y
N
-----
K
P
--------------
L
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
320
Blastp_CBE
41.13
33%
-57
- C5 -
-
3ZO4
7.6
-
KAPCA_BOVIN
A:
[49-347]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
118
Blastp_CBE
41.16
38%
-77
- C5 -
-
4FG9
5.9
-
KCC1A_HUMAN
A:
[20-279]
--------------------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
----
K
E
------------
E
N
E
I
A
V
L
H
-
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
-----
D
---
E
D
---
S
K
---
I
---
M
--
I
S
D
F
-----------------------------
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
--------
K
A
-------
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
--
L
F
E
-
Q
I
--
L
K
A
EY
E
--
F
-
D
S
P
Y
----
W
DD--
I
S
--
D
------
S
--
A
K
D
--
F
I
R
H
L
M
E
K
D
P
E
K
-----
R
-----
F
-----
T
C
E
Q
A
L
Q
H
P
W
I
A
-----
G
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
253
Blastp_CBE
41.15
33%
-58
- C5 -
-
3O7L
5.5
-
KAPCA_MOUSE
B:
[48-346]
-------------------------------
T
L
G
T
G
---
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
I
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
I
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
N
F
D
D
Y
E
--
E
E
E
I
R
V
S
I
------
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
461
Blastp_CBE
41.05
33%
-56
- C5 -
-
4DH1
6.7
-
KAPCA_MOUSE
A:
[48-346]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
204
Blastp_CBE
41.13
33%
-51
- C5 -
-
4WB6
8.8
-
KAPCA_HUMAN
B:
[48-346]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
R
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
452
Blastp_CBE
41.03
33%
-54
- C5 -
-
4DG3
6.8
-
KAPCA_MOUSE
E:
[69-367]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
N
F
D
D
Y
E
--
E
E
E
I
A
V
S
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
457
Blastp_CBE
41.07
33%
-55
- C5 -
-
4DH8
8.2
-
KAPCA_MOUSE
A:
[48-346]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
318
Blastp_CBE
41.06
33%
-54
- C5 -
-
6E99
7.5
-
KAPCA_BOVIN
A:
[49-347]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
117
Blastp_CBE
41.05
38%
-78
- C5 -
-
4FG9
6.2
-
KCC1A_HUMAN
B:
[20-279]
--------------------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
----
K
---------------
E
I
A
V
L
H
-
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
-----
D
---
E
D
---
S
K
---
I
---
M
--
I
S
D
F
---------------------
V
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
--------
K
A
-------
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
--
L
F
E
-
Q
I
--
L
K
A
EY
E
--
F
-
D
S
P
Y
----
W
DD--
I
S
--
D
------
S
--
A
K
D
--
F
I
R
H
L
M
E
K
D
P
E
K
-----
R
-----
F
-----
T
C
E
Q
A
L
Q
H
P
W
I
A
-----
G
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
317
Blastp_CBE
41.03
33%
-53
- C5 -
-
6E9L
7.4
-
KAPCA_BOVIN
A:
[49-347]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
360
Blastp_CBE
41.02
33%
-53
- C5 -
-
2GNF
4.9
-
KAPCA_BOVIN
A:
[48-346]
-------------------------------
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
K
--
V
A
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
312
Blastp_CBE
40.98
33%
-51
- C5 -
-
3MVJ
5.2
-
KAPCA_HUMAN
A:
[69-367]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
454
Blastp_CBE
40.97
33%
-59
- C5 -
-
5JR7
5.1
-
KAPCA_MOUSE
A:
[48-346]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
116
Blastp_CBE
40.94
38%
-76
- C5 -
-
4FG8
5.8
-
KCC1A_HUMAN
A:
[20-279]
--------------------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
----
K
-------------
E
N
E
I
A
V
L
H
-
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
-----
D
---
E
D
---
S
K
---
I
---
M
--
I
S
D
F
----------------------------
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
--------
K
A
-------
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
--
L
F
E
-
Q
I
--
L
K
A
EY
E
--
F
-
D
S
P
Y
----
W
DD--
I
S
--
D
------
S
--
A
K
D
--
F
I
R
H
L
M
E
K
D
P
E
K
-----
R
-----
F
-----
T
C
E
Q
A
L
Q
H
P
W
I
A
-----
G
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
509
Blastp_CBE
40.87
33%
-57
- C5 -
-
3ZO2
6.7
-
KAPCA_BOVIN
A:
[49-347]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
499
Blastp_CBE
40.85
33%
-54
- C5 -
-
3ZO3
7.0
-
KAPCA_BOVIN
A:
[49-347]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
551
Blastp_CBE
40.78
35%
-65
- C5 -
-
4FSQ
8.6
-
CHK1_HUMAN
A:
[10-270]
----------------------------
L
V
Q
T
L
G
----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
------------------
I
K
K
E
I
C
I
N
K
-
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
-----
D
---
E
R
---
D
N
---
L
---
K
--
I
S
D
F
G
L
A
-
T
V
----
F
RYN
N
R
E
---
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
--
E
P
-------
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
---
P
S
--
D
S
C
-
Q
E
--
Y
S
D
--
W
--
K
-
E
K
K
T
----
Y
----
L
N
--
P
WKKIDS
A
--
P
L
A
--
L
L
H
K
I
L
V
E
N
P
S
A
-----
R
-----
I
-----
T
I
P
D
I
K
K
D
R
W
Y
N
-----
K
P
--------------
L
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
379
Blastp_CBE
40.72
33%
-56
- C5 -
-
1Q24
7.5
-
KAPCA_BOVIN
A:
[48-346]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
168
Blastp_CBE
40.69
39%
-74
- C5 -
-
2JAM
6.2
-
KCC1G_HUMAN
A:
[11-264]
--------------------------
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
----
K
---------
S
S
-
L
E
N
E
I
A
V
L
K
-
K
I
K
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
G
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y--
L
-----
T
---
P
E
---
E
N
---
S
---
K
IM
I
T
D
F
G
L
S
-
K
M
----
E
---
Q
N
G
----
I
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
-----
K
--
A
--------
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
T
E
S
K
--
L
F
E
-
K
I
--
K
E
G
--
Y
YE
F
-
E
S
P
F
----
W
DD--
I
S
--
E
------
S
--
A
K
D
--
F
I
C
H
L
L
E
K
D
P
N
E
-----
R
-----
Y
-----
T
C
E
K
A
L
S
H
P
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
502
Blastp_CBE
40.68
33%
-54
- C5 -
-
3KKV
7.5
-
KAPCA_BOVIN
A:
[48-346]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
319
Blastp_CBE
40.60
33%
-54
- C5 -
-
4IE9
4.9
-
KAPCA_BOVIN
A:
[49-347]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
552
Blastp_CBE
40.54
35%
-66
- C5 -
-
4FSM
7.4
-
CHK1_HUMAN
A:
[10-270]
----------------------------
L
V
Q
T
L
G
E
---
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
----------------
N
-
I
K
K
E
I
C
I
N
K
-
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
-----
D
---
E
R
---
D
N
---
L
---
K
--
I
S
D
F
G
L
A
-
T
V
----
F
RYN
N
R
E
---
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
--
E
P
-------
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
---
P
S
--
D
S
C
-
Q
E
--
Y
S
D
--
W
--
K
-
E
K
K
T
----
Y
----
L
N
--
P
WKKIDS
A
--
P
L
A
--
L
L
H
K
I
L
V
E
N
P
S
A
-----
R
-----
I
-----
T
I
P
D
I
K
K
D
R
W
Y
N
-----
K
P
--------------
L
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
515
Blastp_CBE
40.41
36%
-48
- C5 -
-
4YUQ
5.8
-
?
B:
[38-310]
--------------------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
V
T
G
Q
E
Y
A
V
K
V
I
S
----
K
R
Q
----------
L
L
K
E
V
E
L
L
K
-
K
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
NKR
K
D
---
A
N
---
I
---
R
--
I
I
D
F
G
L
S
-
T
H
----
F
---
E
S
T
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
F
D
--
I
L
K
-
K
V
--
E
K
G
KF
T
--
F
-
D
L
P
Q
----
W
----
K
K
--
V
------
S
EP
A
K
D
--
L
I
R
K
M
L
A
Y
V
P
T
M
-----
R
-----
I
-----
S
A
R
D
A
L
E
H
E
W
L
K
-----
T
T
--------------
D
---
D
S
I
----
D
V
P
S
L
E
S
T
I
L
--
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
453
Blastp_CBE
40.47
33%
-55
- C5 -
-
5JR7
5.7
-
KAPCA_MOUSE
C:
[48-346]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
A
-
K
R
----
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
--
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
S
----
H
----
F
S
--
S
------
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
----
G
D
T
S
-
N
F
D
D
Y
--
E
E
E
E
I
R
V
I
N
E
K
--
C
G
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
167
Blastp_CBE
40.41
39%
-69
- C5 -
-
2JAM
5.8
-
KCC1G_HUMAN
B:
[11-264]
--------------------------
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
----
K
---------
S
S
-
L
E
N
E
I
A
V
L
K
-
K
I
K
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
G
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y--
L
-----
T
---
P
E
---
E
N
---
S
---
K
IM
I
T
D
F
G
L
S
-
K
M
----
E
---
Q
N
G
----
I
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
-----
K
--
A
--------
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
T
E
S
K
--
L
F
E
-
K
I
--
K
E
G
--
Y
YE
F
-
E
S
P
F
----
W
DD--
I
S
--
E
------
S
--
A
K
D
--
F
I
C
H
L
L
E
K
D
P
N
E
-----
R
-----
Y
-----
T
C
E
K
A
L
S
H
P
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
169
Blastp_CBE
40.28
39%
-91
- C5 -
-
2W4O
4.5
-
KCC4_HUMAN
A:
[61-308]
--------------------------------
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
L
K
----
K
----------------
I
G
V
L
L
-
R
L
S
H
P
N
I
I
K
L
K
E
I
F
E
T
P
T
E
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
K
G
Y
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
Y
ATPAP
D
---
A
P
---
L
--------
K
--
I
A
D
F
---------------------------
G
T
P
G
Y
C
A
P
E
I
L
R
G
C
A
Y
------
G
--
P
E
-------
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
D
E
R
G
D
Q
F-
M
F
R
-
R
I
LN
C
E
Y
--
Y
--
F
-
I
S
P
W
----
W
----
D
E
--
V
------
S
--
L
N
A
KD
L
V
R
K
L
I
V
L
D
P
K
K
-----
R
-----
L
-----
T
T
F
Q
A
L
Q
H
P
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
519
Blastp_CBE
40.22
36%
-48
- C5 -
-
4YSJ
6.1
-
?
B:
[38-310]
--------------------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
V
T
G
Q
E
Y
A
V
K
V
I
S
----
K
R
-----------
L
L
K
E
V
E
L
L
K
-
K
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
NKR
K
D
---
A
N
---
I
---
R
--
I
I
D
F
G
L
S
-
T
H
----
F
---
E
S
T
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
F
D
--
I
L
K
-
K
V
--
E
K
G
KF
T
--
F
-
D
L
P
Q
----
W
----
K
K
--
V
------
S
EP
A
K
D
--
L
I
R
K
M
L
A
Y
V
P
T
M
-----
R
-----
I
-----
S
A
R
D
A
L
E
H
E
W
L
K
-----
T
T
--------------
D
A
--
D
S
I
----
D
V
P
S
L
E
S
T
I
L
--
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
541
Blastp_CBE
40.15
35%
-66
- C5 -
-
4FTM
7.3
-
CHK1_HUMAN
A:
[10-270]
----------------------------
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
----------------
N
-
I
K
K
E
I
C
I
N
K
-
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
-----
D
---
E
R
---
D
N
---
L
---
K
--
I
S
D
F
G
L
A
-
T
V
----
F
RYN
N
R
E
---
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
--
E
P
-------
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
---
P
S
--
D
S
C
-
Q
E
--
Y
S
D
--
W
--
K
-
E
K
K
T
----
Y
----
L
N
--
P
WKKIDS
A
--
P
L
A
--
L
L
H
K
I
L
V
E
N
P
S
A
-----
R
-----
I
-----
T
I
P
D
I
K
K
D
R
W
Y
N
-----
K
P
--------------
L
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
543
Blastp_CBE
40.02
35%
-68
- C5 -
-
4FTK
8.6
-
CHK1_HUMAN
A:
[10-270]
----------------------------
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
----------------
N
-
I
K
K
E
I
C
I
N
K
-
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
-----
D
---
E
R
---
D
N
---
L
---
K
--
I
S
D
F
G
L
A
-
T
V
----
F
RYN
N
R
E
---
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
--
E
P
-------
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
---
P
S
--
D
S
C
-
Q
E
--
Y
S
D
--
W
--
K
-
E
K
K
T
----
Y
----
L
N
--
P
WKKIDS
A
--
P
L
A
--
L
L
H
K
I
L
V
E
N
P
S
A
-----
R
-----
I
-----
T
I
P
D
I
K
K
D
R
W
Y
N
-----
K
P
--------------
L
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
166
Blastp_CBE
39.82
37%
-65
- C5 -
-
4MVF
7.9
-
CDPK2_PLAFK
A:
[51-323]
-----------------
H
S
G
K
L
E
-
D
K
Y
I
I
D
E
K
L
G
Q
G
T
Y
G
C
V
Y
K
G
I
D
K
V
T
N
Q
L
Y
A
I
K
E
E
K
----
K
D
R
L
K
N
---
I
N
R
-
F
F
Q
E
I
E
I
M
K
-
K
L
D
H
P
N
I
V
K
L
Y
E
T
Y
E
N
D
N
Y
I
Y
L
I
M
E
L
C
S
G
R
E
L
F
D
S
I
I
E
N
G
S
F
T
E
K
N
A
A
T
I
M
K
Q
I
F
S
A
I
F
Y
L
H
S
L
N
I
V
H
R
D
L
K
P
E
N
F
L
---
F
-----
Q
---
S
E
---
N
K
DSL
L
---
K
--
I
I
D
F
G
L
S
-
K
N
----
L
-----------------------------
K
Y
-------
D
--
K
K
-------
C
D
I
W
S
S
G
V
I
M
Y
T
L
L
C
G
Y
P
P
F
Y
---------------------
C
--
F
-
Y
E
N
D
----
W
GS--
I
S
--
S
------
D
--
A
K
N
--
L
I
T
K
L
L
T
Y
N
P
N
E
-----
R
-----
C
-----
T
I
E
E
A
L
N
H
P
W
I
T
-----
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
540
Blastp_CBE
39.74
35%
-65
- C5 -
-
4FTO
6.6
-
CHK1_HUMAN
A:
[10-270]
----------------------------
L
V
Q
T
L
G
----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
---------------
E
N
-
I
K
K
E
I
C
I
N
K
-
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
----
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
-----
D
---
E
R
---
D
N
---
L
---
K
--
I
S
D
F
G
L
A
-
T
V
----
F
RYN
N
R
E
---
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
--
E
P
-------
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
---
P
S
--
D
S
C
-
Q
E
--
Y
S
D
--
W
--
K
-
E
K
K
T
----
Y
----
L
N
--
P
WKKIDS
A
--
P
L
A
--
L
L
H
K
I
L
V
E
N
P
S
A
-----
R
-----
I
-----
T
I
P
D
I
K
K
D
R
W
Y
N
-----
K
P
--------------
L
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
539
Blastp_CBE
39.73
35%
-64
- C5 -
-
4FTR
7.5
-
CHK1_HUMAN
A:
[10-270]
----------------------------
L
V
Q
T
L
G
E
--
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
---------------
E
N
-
I
K
K
E
I
C
I
N
K
-
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
-----
D
---
E
R
---
D
N
---
L
---
K
--
I
S
D
F
G
L
A
-
T
V
----
F
RYN
N
R
E
---
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
--
E
P
-------
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
---
P
S
--
D
S
C
-
Q
E
--
Y
S
D
--
W
--
K
-
E
K
K
T
----
Y
----
L
N
--
P
WKKIDS
A
--
P
L
A
--
L
L
H
K
I
L
V
E
N
P
S
A
-----
R
-----
I
-----
T
I
P
D
I
K
K
D
R
W
Y
N
-----
K
P
--------------
L
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
542
Blastp_CBE
39.67
35%
-68
- C5 -
-
4FTL
9.3
-
CHK1_HUMAN
A:
[10-270]
----------------------------
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
----------------
N
-
I
K
K
E
I
C
I
N
K
-
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
-----
D
---
E
R
---
D
N
---
L
---
K
--
I
S
D
F
G
L
A
-
T
V
----
F
RYN
N
R
E
---
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
--
E
P
-------
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
---
P
S
--
D
S
C
-
Q
E
--
Y
S
D
--
W
--
K
-
E
K
K
T
----
Y
----
L
N
--
P
WKKIDS
A
--
P
L
A
--
L
L
H
K
I
L
V
E
N
P
S
A
-----
R
-----
I
-----
T
I
P
D
I
K
K
D
R
W
Y
N
-----
K
P
--------------
L
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
526
Blastp_CBE
39.60
33%
-87
- C5 -
-
4PDS
5.1
-
RAD53_YEAST
A:
[34-305]
---------------------------
I
I
D
E
V
-------
T
V
K
K
A
I
E
R
T
T
G
K
T
F
S
V
K
I
I
------------------
V
T
R
E
L
E
V
L
Q
-
K
L
N
H
P
R
I
V
R
L
K
G
F
Y
---
E
S
Y
Y
M
V
M
E
F
V
S
G
G
D
L
M
D
F
V
A
A
H
G
A
V
G
E
D
A
G
R
E
I
S
R
Q
I
L
T
A
I
K
Y
I
H
S
M
G
I
S
H
R
D
L
K
P
D
N
I
L
---
I
EQ---
D
---
D
P
---
V
L
---
V
---
K
--
I
T
A
F
G
L
A
-
K
V
------------------------
A
Y
V
A
P
E
V
I
R
---------------RNEYSSL
V
D
M
W
S
M
G
C
L
V
Y
V
I
L
T
G
H
L
P
F
S
G
S
T
Q
D
Q
--
L
Y
K
-
Q
I
--
G
R
G
--
S
--
Y
-
H
E
G
P
----
L
KDFR
I
S
--
E
------
E
--
A
R
D
--
F
I
D
S
L
L
Q
V
D
P
N
N
-----
R
-----
S
-----
T
A
A
K
A
L
N
H
P
W
I
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
538
Blastp_CBE
39.45
35%
-62
- C5 -
-
4FTT
7.0
-
CHK1_HUMAN
A:
[10-270]
----------------------------
L
V
Q
T
L
G
E
---
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
---------------
N
-
I
K
K
E
I
C
I
N
K
-
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
-----
D
---
E
R
---
D
N
---
L
---
K
--
I
S
D
F
G
L
A
-
T
V
----
F
RYN
N
R
E
---
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
--
E
P
-------
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
---
P
S
--
D
S
C
-
Q
E
--
Y
S
D
--
W
--
K
-
E
K
K
T
----
Y
----
L
N
--
P
WKKIDS
A
--
P
L
A
--
L
L
H
K
I
L
V
E
N
P
S
A
-----
R
-----
I
-----
T
I
P
D
I
K
K
D
R
W
Y
N
-----
K
P
--------------
L
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
277
Blastp_CBE
38.51
38%
-21
- C5 -
-
2Y7J
6.0
-
PHKG2_HUMAN
B:
[100-365]
------------------------------
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
VTA---
S
P
E
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
-----
D
---
D
N
---
M
Q
---
I
---
R
--
L
S
D
F
G
F
S
-
C
H
----
L
---
E
P
G
---
E
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
D
E
THPGY
G
--
K
E
-------
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
I
L
--
M
L
R
-
M
I
--
M
E
G
QY
Q
--
F
-
S
S
P
E
----
W
----
D
D
--
R
------
S
ST
V
K
D
--
L
I
S
R
L
L
Q
V
D
P
E
A
-----
R
-----
L
-----
T
A
E
Q
A
L
Q
H
P
F
F
E
-----
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
275
Blastp_CBE
38.17
38%
-8
- C5 -
-
2Y7J
6.2
-
PHKG2_HUMAN
D:
[100-365]
------------------------------
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V---
R
L
S
P
E
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
-----
D
---
D
N
---
M
Q
---
I
---
R
--
L
S
D
F
G
F
S
-
C
H
----
L
---
E
P
G
---
E
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
D
E
THPGY
G
--
K
E
-------
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
I
L
--
M
L
R
-
M
I
--
M
E
G
QY
Q
--
F
-
S
S
P
E
----
W
----
D
D
--
R
------
S
ST
V
K
D
--
L
I
S
R
L
L
Q
V
D
P
E
A
-----
R
-----
L
-----
T
A
E
Q
A
L
Q
H
P
F
F
E
-----
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
276
Blastp_CBE
37.26
38%
-5
- C5 -
-
2Y7J
5.8
-
PHKG2_HUMAN
C:
[100-365]
------------------------------
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
VTAE
R
L
S
P
E
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
-----
D
---
D
N
---
M
Q
---
I
---
R
--
L
S
D
F
G
F
S
-
C
H
----
L
---
E
P
G
---
E
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
D
E
THPGY
G
--
K
E
-------
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
I
L
--
M
L
R
-
M
I
--
M
E
G
QY
Q
--
F
-
S
S
P
E
----
W
----
D
D
--
R
------
S
ST
V
K
D
--
L
I
S
R
L
L
Q
V
D
P
E
A
-----
R
-----
L
-----
T
A
E
Q
A
L
Q
H
P
F
F
E
-----
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
278
Blastp_CBE
37.09
38%
-8
- C5 -
-
2Y7J
6.5
-
PHKG2_HUMAN
A:
[100-365]
------------------------------
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
VTAE
R
L
S
P
E
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
-----
D
---
D
N
---
M
Q
---
I
---
R
--
L
S
D
F
G
F
S
-
C
H
----
L
---
E
P
G
---
E
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
D
E
THPGY
G
--
K
E
-------
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
I
L
--
M
L
R
-
M
I
--
M
E
G
QY
Q
--
F
-
S
S
P
E
----
W
----
D
D
--
R
------
S
ST
V
K
D
--
L
I
S
R
L
L
Q
V
D
P
E
A
-----
R
-----
L
-----
T
A
E
Q
A
L
Q
H
P
F
F
E
-----
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
524
Blastp_CBE
20.97
36%
-8
- C5 -
-
4FSY
Error
-
CHK1_HUMAN
A:
[10-270]
----------------------------
L
V
Q
T
L
G
E
G
--
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
--------------
P
E
N
-
I
K
K
E
I
I
N
-
K
-
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
-----
D
---
E
R
---
D
N
---
L
---
K
--
I
S
D
F
G
L
A
-
T
V
----
F
RYN
N
R
E
---
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
--
E
P
-------
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
---
P
S
--
D
S
C
-
Q
E
--
Y
S
D
--
W
--
K
-
E
K
K
T
----
Y
----
L
N
--
P
WKKIDS
A
--
P
L
A
--
L
L
H
K
I
L
V
E
N
P
S
A
-----
R
-----
I
-----
T
I
P
D
I
K
K
D
R
W
Y
N
-----
K
P
--------------
L
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
:
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
:
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
:
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
:
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------