@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Screening
Virtual Screening Score
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : AAPK2_HUMAN: (2020-09-03 )
MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR
Atome Classification :
(448 SA)
.........10........20........30........40.......----.50........60.........-70.-.......80........90........100.......110.......120.......130.......140....---.-----.---.150-..---.----.--.....160---..-.---...---..170.......180.......190----.--..-------.....200.......210..---.....220-.-..-.....--230.-.---.--.----.--.----...240.........250...-----.-----.-----..260.......-----270-------.--------------.......-.280.....-.--.290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(pKd)
(pKd)
(Uniprot)
MAEKQKHDG
R
V
K
I
G
H
Y
V
LGDTLGVG
T
F
G
K
V
K
IGEHQLT
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
K
R
E
I
Q
N
L
K
-
L
FR-HP
H
I
I
K
L
Y
Q
V
ISTP
T
D
F
F
M
V
M
E
Y
VSG
G
E
L
F
D
Y
I
C
KHG
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
HRDLKPE
N
V
L
---
L
-----D---AH---MN---A----
K
--
I
A
D
F
G
L
S
----
N
M-M---SDG---
E
F
L
R
TSCGSPNYAA
P
E
VISGRLYA-----G--PE-------
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
CGTLPF---DDE
H
V
P
T
--
L
-
F
K
-
K
IRG
G
--
V
--
F
-Y---
I
--
P
----
E
--
Y
----
L
N
R
S
--
V
A
T
L
L
M
H
M
L
QVDPL
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
---------D--------------
L
P
S
YLFP-EDPSYDANV-I--
D
D
E
A
V
K
E
V
C
E
KFEC
T
E
S
E
V
M
N
S
L
YSGDP
Q
D
Q
L
A
V
A
Y
H
L
I
ID
N
R
R
I
M
N
Q
A
S
E
F
Y
LASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKS
L
A
V
K
K
A
K
W
H
LGIRSQSK
P
Y
D
I
M
A
E
V
Y
R
A
M
K
QLD
F
E
W
K
V
V
N
A
Y
H
L
R
V
R
RKNPVTG
N
Y
V
K
M
S
L
Q
L
Y
L
VDN
R
S
Y
L
L
D
FKSI
D
D
E
V
V
E
QRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSG
S
L
TGSLTGS
T
L
S
SVSPRLGS
H
T
M
D
F
F
E
M
C
A
S
L
I
T
T
LAR
24
Blastp_CBE
98.28
99%
-142
- C3 -
-
6B1U
-
-
AAPK2_HUMAN
C:
[22-565]
--------
G
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
K
R
E
I
Q
N
L
K
-
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
----
K
--
I
A
D
F
G
L
S
----
N
M
-
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
---
D
D
E
H
V
P
T
--
L
-
F
K
-
K
I
R
G
G
--
V
--
F
-
Y
---
I
--
P
----
E
--
Y
----
L
N
R
S
--
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
---------
G
--------------
L
P
S
Y
L
F
P
-
E
D
P
S
Y
D
A
N
V
-
I
--
D
D
E
A
V
K
E
V
C
E
K
F
E
C
T
E
S
E
V
M
N
S
L
Y
S
G
D
P
Q
D
Q
L
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
Q
A
S
E
F
Y
L
A
S
S
P
----------
M
H
I
P
P
G
L
K
P
H
P
E
R
M
P
P
L
I
A
D
-------------------
A
V
K
K
A
K
W
H
L
G
I
R
S
Q
S
K
P
Y
D
I
M
A
E
V
Y
R
A
M
K
Q
L
D
F
E
W
K
V
V
N
A
Y
H
L
R
V
R
R
K
N
P
V
T
G
N
Y
V
K
M
S
L
Q
L
Y
L
V
D
N
R
S
Y
L
L
D
F
K
S
I
D
D
-------------------------------------------------------
P
R
L
G
S
H
T
M
D
F
F
E
M
C
A
S
L
I
T
T
L
A
R
556
HHSearch
97.94
97%
-142
- C3 -
-
6B1U
-
-
AAPK2_HUMAN
C:
[22-565]
--------
G
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
K
R
E
I
Q
N
L
K
-
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
----
K
--
I
A
D
F
G
L
S
----
N
M
-
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
---
D
D
E
H
V
P
T
--
L
-
F
K
-
K
I
R
G
G
--
V
--
F
-
Y
---
I
--
P
----
E
--
Y
----
L
N
R
S
--
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
---------
G
--------------
L
P
S
Y
L
F
P
-
E
D
P
S
Y
D
A
N
V
-
I
--
D
D
E
A
V
K
E
V
C
E
K
F
E
C
T
E
S
E
V
M
N
S
L
Y
S
G
D
P
Q
D
Q
L
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
Q
A
S
E
F
Y
L
A
S
S
P
----------
M
H
I
P
P
G
L
K
P
H
P
E
R
M
P
P
L
I
A
D
-------------------
A
V
K
K
A
K
W
H
L
G
I
R
S
Q
S
K
P
Y
D
I
M
A
E
V
Y
R
A
M
K
Q
L
D
F
E
W
K
V
V
N
A
Y
H
L
R
V
R
R
K
N
P
V
T
G
N
Y
V
K
M
S
L
Q
L
Y
L
V
D
N
R
S
Y
L
L
D
F
K
S
I
D
D
-------------------------------------------------------
P
R
L
G
S
H
T
M
D
F
F
E
M
C
A
S
L
I
T
T
L
A
R
1
PsiBlast_PDB
97.44
100%
-140
- C3 -
-
5ISO
-
-
?
A:
[9-551]
--------
G
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
K
R
E
I
Q
N
L
K
-
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
----
K
--
I
A
D
F
G
L
S
----
N
M
-
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
---
D
D
E
H
V
P
T
--
L
-
F
K
-
K
I
R
G
G
--
V
--
F
-
Y
---
I
--
P
----
E
--
Y
----
L
N
R
S
--
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
---------
D
--------------
L
P
S
Y
L
F
P
-
E
D
P
S
Y
D
A
N
V
-
I
--
D
D
E
A
V
K
E
V
C
E
K
F
E
C
T
E
S
E
V
M
N
S
L
Y
S
G
D
P
Q
D
Q
L
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
Q
A
S
E
F
Y
L
A
S
S
P
----------------
L
K
P
H
P
E
R
M
P
P
L
I
A
D
S
-------------------
V
K
K
A
K
W
H
L
G
I
R
S
Q
S
K
P
Y
D
I
M
A
E
V
Y
R
A
M
K
Q
L
D
F
E
W
K
V
V
N
A
Y
H
L
R
V
R
R
K
N
P
V
T
G
N
Y
V
K
M
S
L
Q
L
Y
L
V
D
N
R
S
Y
L
L
D
F
K
S
I
D
D
-------------------------------------------------------
P
R
L
G
S
H
T
M
D
F
F
E
M
C
A
S
L
I
T
T
L
A
-
5
PsiBlast_PDB
95.00
99%
-140
- C3 -
-
6B1U
-
-
AAPK2_HUMAN
A:
[21-563]
-------
D
G
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
K
R
E
I
Q
N
L
K
-
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
----
K
--
I
A
D
F
G
L
S
----
N
M
-
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
---
D
D
E
H
V
P
T
--
L
-
F
K
-
K
I
R
G
G
--
V
--
F
-
Y
---
I
--
P
----
E
--
Y
----
L
N
R
S
--
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
---------
G
--------------
L
P
S
Y
L
F
P
-
E
D
P
S
Y
D
A
N
V
-
I
--
D
D
E
A
V
K
E
V
C
E
K
F
---
E
S
E
V
M
N
S
L
Y
----
Q
D
Q
L
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
Q
A
S
E
F
Y
L
A
S
S
P
----------------
L
K
P
H
P
E
R
M
P
P
L
I
-----------------------
K
K
A
K
W
H
L
G
I
R
S
Q
S
K
P
Y
D
I
M
A
E
V
Y
R
A
M
K
Q
L
D
F
E
W
K
V
V
N
A
Y
H
L
R
V
R
R
K
N
P
V
T
G
N
Y
V
K
M
S
L
Q
L
Y
L
V
D
N
R
S
Y
L
L
D
F
K
S
I
D
D
-------------------------------------------------------
P
R
L
G
S
H
T
M
D
F
F
E
M
C
A
S
L
I
T
T
L
--
25
Blastp_CBE
94.36
99%
-133
- C3 -
-
4ZHX
-
-
AAPK2_HUMAN
C:
[22-564]
--------
G
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
K
R
E
I
Q
N
L
K
-
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
----
K
--
I
A
D
F
G
L
S
----
N
M
-
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
---
D
D
E
H
V
P
T
--
L
-
F
K
-
K
I
R
G
G
--
V
--
F
-
Y
---
I
--
P
----
E
--
Y
----
L
N
R
S
--
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
---------
G
--------------
L
P
S
Y
L
F
P
-
E
D
P
S
Y
D
A
N
V
-
I
--
D
D
E
A
V
K
E
V
C
---
E
C
T
E
S
E
V
M
N
S
L
Y
S
G
D
P
Q
D
Q
L
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
Q
A
S
E
F
Y
L
A
S
S
---------
S
A
M
H
I
P
P
G
L
K
P
H
P
E
R
M
P
P
L
I
A
--------------------
A
V
K
K
A
K
W
H
L
G
I
R
S
Q
S
K
P
Y
D
I
M
A
E
V
Y
R
A
M
K
Q
L
D
F
E
W
K
V
V
N
A
Y
H
L
R
V
R
R
K
N
P
V
T
G
N
Y
V
K
M
S
L
Q
L
Y
L
V
D
N
R
S
Y
L
L
D
F
K
S
I
D
----------------------------------------------------------
L
G
S
H
T
M
D
F
F
E
M
C
A
S
L
I
T
T
L
A
-
7
PsiBlast_PDB
93.79
94%
-142
- C3 -
-
5EZV
-
-
AAPK1_HUMAN (first)
A:
[22-559]
-------
D
G
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
K
R
E
I
Q
N
L
K
-
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
----
K
--
I
A
D
F
G
L
S
----
N
M
-
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
---
D
D
E
H
V
P
T
--
L
-
F
K
-
K
I
R
G
G
--
V
--
F
-
Y
---
I
--
P
----
E
--
Y
----
L
N
R
S
--
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
---------
D
--------------
L
P
S
Y
L
F
P
-
E
D
P
S
Y
D
A
N
V
-
I
--
D
D
E
A
V
K
E
V
C
E
K
F
E
C
T
E
S
E
V
M
N
S
L
Y
S
G
D
P
Q
D
Q
L
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
Q
A
S
E
F
Y
L
A
S
-------------------
R
P
H
P
E
R
V
P
F
--------------------------
K
A
K
W
H
L
G
I
R
S
Q
S
K
P
Y
D
I
M
A
E
V
Y
R
A
M
K
Q
L
D
F
E
W
K
V
V
N
A
Y
H
L
R
V
R
R
K
N
P
V
T
G
N
Y
V
K
M
S
L
Q
L
Y
L
V
D
N
R
S
Y
L
L
D
F
K
S
I
D
D
---------------------------------------------------------
L
G
S
H
T
M
D
F
F
E
M
C
A
S
L
I
T
T
L
A
-
26
Blastp_CBE
92.94
95%
-128
- C3 -
-
5EZV
-
-
AAPK1_HUMAN (first)
C:
[23-559]
--------
G
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
K
R
E
I
Q
N
L
K
-
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
----
K
--
I
A
D
F
G
L
S
----
N
M
-
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
---
D
D
E
H
V
P
T
--
L
-
F
K
-
K
I
R
G
G
--
V
--
F
-
Y
---
I
--
P
----
E
--
Y
----
L
N
R
S
--
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
---------
D
--------------
L
P
S
Y
L
F
P
-
E
D
P
S
Y
D
A
N
V
-
I
--
D
D
E
A
V
K
E
V
C
E
K
F
E
C
T
E
S
E
V
M
N
S
L
Y
S
G
D
P
--
Q
L
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
Q
A
S
E
F
Y
L
A
S
S
------------------
R
P
H
P
E
R
V
----------------------------
K
A
K
W
H
L
G
I
R
S
Q
S
K
P
Y
D
I
M
A
E
V
Y
R
A
M
K
Q
L
D
F
E
W
K
V
V
N
A
Y
H
L
R
V
R
R
K
N
P
V
T
G
N
Y
V
K
M
S
L
Q
L
Y
L
V
D
N
R
S
Y
L
L
D
F
K
S
I
D
D
E
------------------------------------------------------
P
R
L
G
S
H
T
M
D
F
F
E
M
C
A
S
L
I
T
T
L
A
-
6
PsiBlast_PDB
91.97
99%
-132
- C3 -
-
6B2E
7.4
-
AAPK2_HUMAN
A:
[22-564]
--------
G
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
K
R
E
I
Q
N
L
K
-
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
----
K
--
I
A
D
F
G
L
S
----
N
M
-
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
---
D
D
E
H
V
P
T
--
L
-
F
K
-
K
I
R
G
G
--
V
--
F
-
Y
---
I
--
P
----
E
--
Y
----
L
N
R
S
--
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
---------
G
--------------
L
P
S
Y
L
F
P
-
E
D
P
S
Y
D
A
N
V
-
I
--
D
D
E
A
V
K
E
V
C
E
K
F
E
C
T
E
S
E
V
M
N
S
L
Y
S
G
D
P
Q
-----
A
Y
H
L
I
I
D
N
R
R
I
M
N
Q
A
S
E
F
Y
L
A
S
S
P
----------------
L
K
P
H
P
E
R
M
P
P
L
I
A
----------------------
K
K
A
K
W
H
L
G
I
R
S
Q
S
K
P
Y
D
I
M
A
E
V
Y
R
A
M
K
Q
L
D
F
E
W
K
V
V
N
A
Y
H
L
R
V
R
R
K
N
P
V
T
G
N
Y
V
K
M
S
L
Q
L
Y
L
V
D
N
R
S
Y
L
L
D
F
K
S
I
D
D
---------------------------------------------------------
L
G
S
H
T
M
D
F
F
E
M
C
A
S
L
I
T
T
L
A
-
2
PsiBlast_PDB
90.40
99%
-132
- C3 -
-
4CFE
-
-
AAPK2_HUMAN
A:
[27-570]
-------
D
G
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
K
R
E
I
Q
N
L
K
-
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
----
K
--
I
A
D
F
G
L
S
----
N
M
-
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
---
D
D
E
H
V
P
T
--
L
-
F
K
-
K
I
R
G
G
--
V
--
F
-
Y
---
I
--
P
----
E
--
Y
----
L
N
R
S
--
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
---------
D
--------------
L
P
S
Y
L
F
P
-
E
D
P
S
Y
D
A
N
V
-
I
--
D
D
E
A
V
K
E
-------------------------
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
Q
A
S
E
F
Y
L
A
S
S
P
----------------
L
K
P
H
P
E
R
M
P
P
L
I
A
D
-------------------
A
V
K
K
A
K
W
H
L
G
I
R
S
Q
S
K
P
Y
D
I
M
A
E
V
Y
R
A
M
K
Q
L
D
F
E
W
K
V
V
N
A
Y
H
L
R
V
R
R
K
N
P
V
T
G
N
Y
V
K
M
S
L
Q
L
Y
L
V
D
N
R
S
Y
L
L
D
F
K
S
I
D
----------------------------------------------------------
L
G
S
H
T
M
D
F
F
E
M
C
A
S
L
I
T
T
L
A
-
21
Blastp_CBE
89.84
100%
-131
- C3 -
-
5ISO
-
-
?
C:
[9-550]
--------
G
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
K
R
E
I
Q
N
L
K
-
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
----
K
--
I
A
D
F
G
L
S
----
N
M
-
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
---
D
D
E
H
V
P
T
--
L
-
F
K
-
K
I
R
G
G
--
V
--
F
-
Y
---
I
--
P
----
E
--
Y
----
L
N
R
S
--
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
---------
D
--------------
L
P
S
Y
L
F
P
-
E
D
P
S
Y
D
A
N
V
-
I
--
D
D
E
A
V
K
E
V
C
--
F
E
-----------------
Q
L
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
Q
A
S
E
F
Y
L
A
S
S
-----------------
L
K
P
H
P
E
R
M
P
P
L
I
---------------------
A
V
K
K
A
K
W
H
L
G
I
R
S
Q
S
K
P
Y
D
I
M
A
E
V
Y
R
A
M
K
Q
L
D
F
E
W
K
V
V
N
A
Y
H
L
R
V
R
R
K
N
P
V
T
G
N
Y
V
K
M
S
L
Q
L
Y
L
V
D
N
R
S
Y
L
L
D
F
K
S
I
D
D
--------------------------------------------------------
R
L
G
S
H
T
M
D
F
F
E
M
C
A
S
L
I
T
T
L
--
22
Blastp_CBE
89.61
99%
-133
- C3 -
-
4CFF
-
-
AAPK2_HUMAN
C:
[29-570]
---------
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
K
R
E
I
Q
N
L
K
-
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
----
K
--
I
A
D
F
G
L
S
----
N
M
-
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
---
D
D
E
H
V
P
T
--
L
-
F
K
-
K
I
R
G
G
--
V
--
F
-
Y
---
I
--
P
----
E
--
Y
----
L
N
R
S
--
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
---------
D
--------------
L
P
S
Y
L
F
P
-
E
D
P
S
Y
D
A
N
V
-
I
--
D
D
E
A
V
K
E
--------------------------
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
Q
A
S
E
F
Y
L
A
S
S
P
----------------
L
K
P
H
P
E
R
M
P
P
L
I
A
D
-------------------
A
V
K
K
A
K
W
H
L
G
I
R
S
Q
S
K
P
Y
D
I
M
A
E
V
Y
R
A
M
K
Q
L
D
F
E
W
K
V
V
N
A
Y
H
L
R
V
R
R
K
N
P
V
T
G
N
Y
V
K
M
S
L
Q
L
Y
L
V
D
N
R
S
Y
L
L
D
F
K
S
I
D
----------------------------------------------------------
L
G
S
H
T
M
D
F
F
E
M
C
A
S
L
I
T
T
L
A
-
555
HHSearch
89.24
97%
-131
- C3 -
-
5ISO
-
-
?
C:
[9-550]
--------
G
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
K
R
E
I
Q
N
L
K
-
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
----
K
--
I
A
D
F
G
L
S
----
N
M
-
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
---
D
D
E
H
V
P
T
--
L
-
F
K
-
K
I
R
G
G
--
V
--
F
-
Y
---
I
--
P
----
E
--
Y
----
L
N
R
S
--
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
---------
D
--------------
L
P
S
Y
L
F
P
-
E
D
P
S
Y
D
A
N
V
-
I
--
D
D
E
A
V
K
E
V
C
--
F
E
-----------------
Q
L
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
Q
A
S
E
F
Y
L
A
S
S
-----------------
L
K
P
H
P
E
R
M
P
P
L
I
---------------------
A
V
K
K
A
K
W
H
L
G
I
R
S
Q
S
K
P
Y
D
I
M
A
E
V
Y
R
A
M
K
Q
L
D
F
E
W
K
V
V
N
A
Y
H
L
R
V
R
R
K
N
P
V
T
G
N
Y
V
K
M
S
L
Q
L
Y
L
V
D
N
R
S
Y
L
L
D
F
K
S
I
D
D
--------------------------------------------------------
R
L
G
S
H
T
M
D
F
F
E
M
C
A
S
L
I
T
T
L
--
3
PsiBlast_PDB
88.98
99%
-131
- C3 -
-
4CFF
-
-
AAPK2_HUMAN
A:
[27-570]
-------
D
G
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
K
R
E
I
Q
N
L
K
-
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
----
K
--
I
A
D
F
G
L
S
----
N
M
-
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
---
D
D
E
H
V
P
T
--
L
-
F
K
-
K
I
R
G
G
--
V
--
F
-
Y
---
I
--
P
----
E
--
Y
----
L
N
R
S
--
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
---------
D
--------------
L
P
S
Y
L
F
P
-
E
D
P
S
Y
D
A
N
V
-
I
--
D
D
E
A
V
K
E
-------------------------
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
Q
A
S
E
F
Y
L
A
S
S
P
----------------
L
K
P
H
P
E
R
M
P
P
L
I
A
--------------------
A
V
K
K
A
K
W
H
L
G
I
R
S
Q
S
K
P
Y
D
I
M
A
E
V
Y
R
A
M
K
Q
L
D
F
E
W
K
V
V
N
A
Y
H
L
R
V
R
R
K
N
P
V
T
G
N
Y
V
K
M
S
L
Q
L
Y
L
V
D
N
R
S
Y
L
L
D
F
K
S
I
D
----------------------------------------------------------
L
G
S
H
T
M
D
F
F
E
M
C
A
S
L
I
T
T
L
A
-
23
Blastp_CBE
88.53
99%
-137
- C3 -
-
4CFE
-
-
AAPK2_HUMAN
C:
[29-570]
---------
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
K
R
E
I
Q
N
L
K
-
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
----
K
--
I
A
D
F
G
L
S
----
N
M
-
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
---
D
D
E
H
V
P
T
--
L
-
F
K
-
K
I
R
G
G
--
V
--
F
-
Y
---
I
--
P
----
E
--
Y
----
L
N
R
S
--
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
---------
D
--------------
L
P
S
Y
L
F
P
-
E
D
P
S
Y
D
---------------------------------------------
I
I
D
N
R
R
I
M
N
Q
A
S
E
F
Y
L
A
S
S
P
----------------
L
K
P
H
P
E
R
M
P
P
----------------------
L
A
V
K
K
A
K
W
H
L
G
I
R
S
Q
S
K
P
Y
D
I
M
A
E
V
Y
R
A
M
K
Q
L
D
F
E
W
K
V
V
N
A
Y
H
L
R
V
R
R
K
N
P
V
T
G
N
Y
V
K
M
S
L
Q
L
Y
L
V
D
N
R
S
Y
L
L
D
F
K
S
I
D
----------------------------------------------------------
L
G
S
H
T
M
D
F
F
E
M
C
A
S
L
I
T
T
L
A
-
4
PsiBlast_PDB
87.20
99%
-137
- C3 -
-
4ZHX
-
-
AAPK2_HUMAN
A:
[22-563]
--------
G
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
K
R
E
I
Q
N
L
K
-
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
----
K
--
I
A
D
F
G
L
S
----
N
M
-
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
---
D
D
E
H
V
P
T
--
L
-
F
K
-
K
I
R
G
G
--
V
--
F
-
Y
---
I
--
P
----
E
--
Y
----
L
N
R
S
--
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
---------
G
--------------
L
P
S
Y
L
F
P
-
E
D
P
S
Y
D
A
N
V
-
I
--
D
D
E
A
V
K
E
V
C
E
----------------------
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
Q
A
S
E
F
Y
L
A
S
------------------------------------------------------
K
A
K
W
H
L
G
I
R
S
Q
S
K
P
Y
D
I
M
A
E
V
Y
R
A
M
K
Q
L
D
F
E
W
K
V
V
N
A
Y
H
L
R
V
R
R
K
N
P
V
T
G
N
Y
V
K
M
S
L
Q
L
Y
L
V
D
N
R
S
Y
L
L
D
F
K
S
I
D
D
---------------------------------------------------------
L
G
S
H
T
M
D
F
F
E
M
C
A
S
L
I
T
T
L
--
557
HHSearch
86.52
74%
-124
- C3 -
-
4RER
9.1
-
AAPK1_HUMAN
A:
[2-540]
---------
S
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
R
R
E
I
Q
N
L
K
-
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
----
K
--
I
A
D
F
G
L
S
----
N
M
-
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
---
D
D
D
H
V
P
T
--
L
-
F
K
-
K
I
C
D
G
--
I
--
F
-
Y
---
T
--
P
----
Q
--
Y
----
L
N
P
S
--
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
-----
R
-----
A
-----
S
I
K
D
I
R
E
H
E
W
F
K
-----
Q
---------
D
--------------
L
P
K
Y
L
F
P
-
E
D
P
S
Y
S
-------
D
D
E
A
L
K
E
V
C
E
K
F
E
C
S
E
E
E
V
L
S
C
L
Y
N
R
N
H
Q
D
P
L
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
F
Y
L
A
T
S
P
P
----
D
------
D
H
H
L
T
R
P
H
P
E
R
V
P
F
L
V
A
E
T
P
-------------------
R
K
A
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
Y
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
G
I
----------------------------------------------------
T
P
R
P
G
S
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
Q
9
PsiBlast_PDB
86.48
74%
-124
- C3 -
-
4RER
9.1
-
AAPK1_HUMAN
A:
[1-540]
--------
G
S
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
R
R
E
I
Q
N
L
K
-
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
----
K
--
I
A
D
F
G
L
S
----
N
M
-
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
---
D
D
D
H
V
P
T
--
L
-
F
K
-
K
I
C
D
G
--
I
--
F
-
Y
---
T
--
P
----
Q
--
Y
----
L
N
P
S
--
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
-----
R
-----
A
-----
S
I
K
D
I
R
E
H
E
W
F
K
-----
Q
---------
D
--------------
L
P
K
Y
L
F
P
-
E
D
P
S
Y
S
-------
D
D
E
A
L
K
E
V
C
E
K
F
E
C
S
E
E
E
V
L
S
C
L
Y
N
R
N
H
Q
D
P
L
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
F
Y
L
A
T
S
P
P
-----
D
D
H
H
L
-----
T
R
P
H
P
E
R
V
P
F
L
V
A
E
T
P
-------------------
R
K
A
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
Y
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
G
I
----------------------------------------------------
T
P
R
P
G
S
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
Q
560
HHSearch
85.67
79%
-123
- C3 -
-
6C9H
8.9
-
AAPK1_HUMAN
A:
[9-493]
--------
G
S
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
R
R
E
I
Q
N
L
K
-
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
----
K
--
I
A
D
F
G
L
S
----
N
M
-
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
---
D
D
D
H
V
P
T
--
L
-
F
K
-
K
I
C
D
G
--
I
--
F
-
Y
---
T
--
P
----
Q
--
Y
----
L
N
P
S
--
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
---------
D
--------------
L
P
K
Y
L
F
P
-
E
D
P
S
Y
S
S
T
M
-
I
--
D
D
E
A
L
K
E
V
--------------
L
Y
N
R
N
H
Q
D
P
L
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
F
Y
L
A
T
S
P
----------------
T
R
P
H
P
E
R
V
P
F
--------------------------
K
A
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
Y
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
E
L
T
P
----------------------------------------------------
R
P
G
S
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
-
20
PsiBlast_PDB
84.63
71%
-123
- C3 -
-
6C9H
8.9
-
AAPK1_HUMAN
A:
[9-493]
--------
G
S
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
R
R
E
I
Q
N
L
K
-
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
----
K
--
I
A
D
F
G
L
S
----
N
M
-
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
---
D
D
D
H
V
P
T
--
L
-
F
K
-
K
I
C
D
G
--
I
--
F
-
Y
---
T
--
P
----
Q
--
Y
----
L
N
P
S
--
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
---------
D
--------------
L
P
K
Y
L
F
P
-
E
D
P
S
Y
S
S
T
M
-
I
--
D
D
E
A
L
K
E
V
--------------
L
Y
N
R
N
H
Q
D
P
L
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
F
Y
L
A
T
S
P
----------------
T
R
P
H
P
E
R
V
P
F
--------------------------
K
A
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
Y
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
E
L
--------
T
P
----------
R
P
G
S
----------------------------------
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
-
558
HHSearch
81.51
79%
-126
- C3 -
-
6C9J
9.1
-
AAPK1_HUMAN
A:
[9-494]
--------
G
S
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
R
R
E
I
Q
N
L
K
-
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
----
K
--
I
A
D
F
G
L
S
----
N
M
-
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
---
D
D
D
H
V
P
T
--
L
-
F
K
-
K
I
C
D
G
--
I
--
F
-
Y
---
T
--
P
----
Q
--
Y
----
L
N
P
S
--
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
---------
D
--------------
L
P
K
Y
L
F
P
-
E
--------------------------------------------------------------------------------------
T
R
P
H
P
E
R
V
P
F
L
V
A
-----------------------
K
A
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
Y
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
E
L
T
P
----------------------------------------------------
R
P
G
S
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
Q
28
Blastp_CBE
80.99
72%
-134
- C3 -
-
6C9G
9.3
-
AAPK1_HUMAN
A:
[9-493]
--------
G
S
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
R
R
E
I
Q
N
L
K
-
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
----
K
--
I
A
D
F
G
L
S
----
N
M
-
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
---
D
D
D
H
V
P
T
--
L
-
F
K
-
K
I
C
D
G
--
I
--
F
-
Y
---
T
--
P
----
Q
--
Y
----
L
N
P
S
--
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
---------
D
--------------
L
P
K
Y
L
F
P
-
E
---------------------------------------------------
I
D
N
R
R
I
M
N
E
A
K
D
F
---------------------------------------------------------
R
K
A
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
Y
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
E
L
--------
T
P
----------
R
P
G
S
----------------------------------
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
-
27
Blastp_CBE
80.98
72%
-125
- C3 -
-
6C9J
9.1
-
AAPK1_HUMAN
A:
[9-494]
--------
G
S
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
R
R
E
I
Q
N
L
K
-
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
----
K
--
I
A
D
F
G
L
S
----
N
M
-
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
---
D
D
D
H
V
P
T
--
L
-
F
K
-
K
I
C
D
G
--
I
--
F
-
Y
---
T
--
P
----
Q
--
Y
----
L
N
P
S
--
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
---------
D
--------------
L
P
K
Y
L
F
P
-
E
--------------------------------------------------------------------------------------
T
R
P
H
P
E
R
V
P
F
L
V
A
-----------------------
K
A
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
Y
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
E
L
--------
T
P
----------
R
P
G
S
----------------------------------
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
Q
29
Blastp_CBE
80.55
72%
-134
- C3 -
-
6C9F
9.2
-
AAPK1_HUMAN
A:
[9-493]
--------
G
S
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
R
R
E
I
Q
N
L
K
-
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
----
K
--
I
A
D
F
G
L
S
----
N
M
-
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
---
D
D
D
H
V
P
T
--
L
-
F
K
-
K
I
C
D
G
--
I
--
F
-
Y
---
T
--
P
----
Q
--
Y
----
L
N
P
S
--
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
---------
D
--------------
L
P
K
Y
L
F
P
-
E
D
-------------------------------------------------------------------------------------------------------------------------
K
A
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
Y
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
E
L
--------
T
P
----------
R
P
G
S
----------------------------------
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
-
15
PsiBlast_PDB
78.80
73%
-131
- C3 -
-
5UFU
9.4
-
AAPK1_MOUSE (first)
A:
[11-503]
--------
G
R
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
R
R
E
I
Q
N
L
K
-
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
----
K
--
I
A
D
F
G
L
S
----
N
M
-
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
---
D
D
D
H
V
P
T
--
L
-
F
K
-
K
I
C
D
G
--
I
--
F
-
Y
---
T
--
P
----
Q
--
Y
----
L
N
P
S
--
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
---------
D
--------------
L
P
K
Y
L
F
P
-
E
---------------------------------------------------------------------------------------------------------------------------
A
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
F
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
E
-------------------------------------------------------
R
P
G
S
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
Q
19
PsiBlast_PDB
78.72
80%
-129
- C3 -
-
4CFH
8.5
-
AAPK1_RAT
A:
[29-489]
---------
R
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
R
R
E
I
Q
N
L
K
-
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
----
K
--
I
A
D
F
G
L
S
----
N
M
-
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
---
D
D
D
H
V
P
T
--
L
-
F
K
-
K
I
C
D
G
--
I
--
F
-
Y
---
T
--
P
----
Q
--
Y
----
L
N
P
S
--
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
---------
D
--------------
L
P
K
Y
L
F
P
-
E
D
-------------------------------------------
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
F
Y
L
A
T
S
P
P
D
-
S
F
L
D
D
H
H
L
-----
T
R
P
H
P
E
R
V
P
F
L
V
A
E
T
P
R
A
-------------------
A
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
F
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
E
I
----------------------------------------------------------------------------
14
PsiBlast_PDB
78.30
73%
-128
- C3 -
-
5T5T
9.7
-
AAPK1_RAT
A:
[11-503]
--------
G
R
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
R
R
E
I
Q
N
L
K
-
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
----
K
--
I
A
D
F
G
L
S
----
N
M
-
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
---
D
D
D
H
V
P
T
--
L
-
F
K
-
K
I
C
D
G
--
I
--
F
-
Y
---
T
--
P
----
Q
--
Y
----
L
N
P
S
--
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
---------
D
--------------
L
P
K
Y
L
F
P
-
E
---------------------------------------------------------------------------------------------------------------------------
A
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
F
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
E
-------------------------------------------------------
R
P
G
S
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
Q
17
PsiBlast_PDB
77.63
73%
-130
- C3 -
-
6E4U
9.4
-
AAPK1_RAT
A:
[11-503]
--------
G
R
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
R
R
E
I
Q
N
L
K
-
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
----
K
--
I
A
D
F
G
L
S
----
N
M
-
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
---
D
D
D
H
V
P
T
--
L
-
F
K
-
K
I
C
D
G
--
I
--
F
-
Y
---
T
--
P
----
Q
--
Y
----
L
N
P
S
--
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
---------
D
--------------
L
P
K
Y
L
F
P
-
E
----------------------------------------------------------------------------------------------------------------------------
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
F
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
---------------------------------------------------------
P
G
S
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
Q
11
PsiBlast_PDB
77.51
73%
-132
- C3 -
-
4QFR
10.3
-
?
A:
[11-503]
--------
G
R
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
R
R
E
I
Q
N
L
K
-
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
----
K
--
I
A
D
F
G
L
S
----
N
M
-
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
---
D
D
D
H
V
P
T
--
L
-
F
K
-
K
I
C
D
G
--
I
--
F
-
Y
---
T
--
P
----
Q
--
Y
----
L
N
P
S
--
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
---------
D
--------------
L
P
K
Y
L
F
-------------------------------------------------------------------------------------------------------------------------------
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
F
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
-----------------------------------------------------------
S
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
Q
18
PsiBlast_PDB
77.50
73%
-134
- C3 -
-
6E4W
9.0
-
?
A:
[11-503]
--------
G
R
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
R
R
E
I
Q
N
L
K
-
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
----
K
--
I
A
D
F
G
L
S
----
N
M
-
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
---
D
D
D
H
V
P
T
--
L
-
F
K
-
K
I
C
D
G
--
I
--
F
-
Y
---
T
--
P
----
Q
--
Y
----
L
N
P
S
--
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
---------
D
--------------
L
P
K
Y
L
F
-------------------------------------------------------------------------------------------------------------------------------
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
F
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
-----------------------------------------------------------
S
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
Q
12
PsiBlast_PDB
77.50
73%
-134
- C3 -
-
4QFS
9.7
-
AAPK1_RAT
A:
[11-503]
--------
G
R
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
R
R
E
I
Q
N
L
K
-
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
----
K
--
I
A
D
F
G
L
S
----
N
M
-
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
---
D
D
D
H
V
P
T
--
L
-
F
K
-
K
I
C
D
G
--
I
--
F
-
Y
---
T
--
P
----
Q
--
Y
----
L
N
P
S
--
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
---------
D
--------------
L
P
K
Y
L
F
-------------------------------------------------------------------------------------------------------------------------------
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
F
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
-----------------------------------------------------------
S
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
Q
16
PsiBlast_PDB
77.26
73%
-135
- C3 -
-
6E4T
9.1
-
?
A:
[11-503]
--------
G
R
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
R
R
E
I
Q
N
L
K
-
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
----
K
--
I
A
D
F
G
L
S
----
N
M
-
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
---
D
D
D
H
V
P
T
--
L
-
F
K
-
K
I
C
D
G
--
I
--
F
-
Y
---
T
--
P
----
Q
--
Y
----
L
N
P
S
--
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
---------
D
--------------
L
P
K
Y
L
F
-------------------------------------------------------------------------------------------------------------------------------
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
F
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
-----------------------------------------------------------
S
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
Q
10
PsiBlast_PDB
77.09
73%
-129
- C3 -
-
4QFG
9.6
-
AAPK1_RAT
A:
[11-503]
--------
G
R
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
R
R
E
I
Q
N
L
K
-
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
----
K
--
I
A
D
F
G
L
S
----
N
M
-
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
---
D
D
D
H
V
P
T
--
L
-
F
K
-
K
I
C
D
G
--
I
--
F
-
Y
---
T
--
P
----
Q
--
Y
----
L
N
P
S
--
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
---------
D
--------------
L
P
K
Y
L
F
P
-------------------------------------------------------------------------------------------------------------------------------
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
F
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
E
-------------------------------------------------------
R
P
G
S
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
Q
13
PsiBlast_PDB
77.04
73%
-131
- C3 -
-
5KQ5
9.5
-
?
A:
[12-503]
---------
R
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
R
R
E
I
Q
N
L
K
-
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
----
K
--
I
A
D
F
G
L
S
----
N
M
-
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
---
D
D
D
H
V
P
T
--
L
-
F
K
-
K
I
C
D
G
--
I
--
F
-
Y
---
T
--
P
----
Q
--
Y
----
L
N
P
S
--
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
---------
D
--------------
L
P
K
Y
L
F
------------------------------------------------------------------------------------------------------------------------------
A
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
F
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
----------------------------------------------------------
P
G
S
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
Q
8
PsiBlast_PDB
76.30
74%
-111
- C3 -
-
4REW
8.9
-
AAPK1_HUMAN
A:
[1-540]
--------
G
S
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
R
R
E
I
Q
N
L
K
-
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
----
K
--
I
A
D
F
G
L
S
----
N
M
-
M
---
S
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
---
D
D
D
H
V
P
T
--
L
-
F
K
-
K
I
C
D
G
--
I
--
F
-
Y
---
T
--
P
----
Q
--
Y
----
L
N
P
S
--
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
-----
R
-----
A
-----
S
I
K
D
I
R
E
H
E
W
F
K
-----
Q
---------
D
--------------
L
P
K
Y
L
F
P
-
E
---------------------------------------------------
I
D
N
R
R
I
M
N
E
A
K
D
F
Y
L
A
T
S
P
P
------
D
H
H
L
-----
T
R
P
H
P
E
R
V
P
F
L
V
A
E
T
--------------------
R
K
A
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
Y
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
G
------------------------------------------------------
P
R
P
G
S
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
Q
30
Blastp_CBE
67.91
99%
-142
- C3 -
-
3AQV
8.3
-
AAPK2_HUMAN
A:
[4-276]
------
H
D
G
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
K
R
E
I
Q
N
L
K
-
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
----
K
--
I
A
D
F
G
L
S
----
N
M
-
M
---
S
D
G
---
E
F
L
------
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
---
D
D
E
H
V
P
T
--
L
-
F
K
-
K
I
R
G
G
--
V
--
F
-
Y
---
I
--
P
----
E
--
Y
----
L
N
R
S
--
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
---------
D
--------------
L
P
S
Y
L
F
P
-
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Blastp_CBE
64.32
99%
-147
- C3 -
-
6BX6
6.6
-
AAPK2_HUMAN
A:
[10-274]
------------
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
K
R
E
I
Q
N
L
K
-
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
---
A
H
---
M
N
---
A
----
K
--
I
A
D
F
G
L
S
---------------------------
N
Y
A
A
P
E
------
Y
A
-----
G
--
P
E
-------
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
---
D
D
E
H
V
P
T
--
L
-
F
K
-
K
I
R
G
G
--
V
--
F
-
Y
---
I
--
P
----
E
--
Y
----
L
N
R
S
--
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
-----
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
---------
D
--------------
L
P
S
Y
L
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
575
HHSearch
61.50
41%
-139
- C3 -
-
5TVT
8.7
-
MELK_HUMAN
A:
[6-328]
---------
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
L
G
--
S
D
L
P
R
-
I
K
T
E
I
E
A
L
K
-
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
----
K
--
L
I
D
F
G
L
C
----
A
K
------------------
G
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
N
V
M
A
--
L
-
Y
K
-
K
I
M
R
G
--
K
--
Y
-
D
---
V
--
P
----
K
--
W
----
L
S
P
S
--
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
---------
D
--------------
Y
N
Y
P
V
E
W
-
Q
S
K
N
-
P
F
I
H
-
L
--
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
-
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Blastp_CBE
61.13
44%
-133
- C3 -
-
5KZ7
7.7
-
MARK2_HUMAN
B:
[30-343]
-----
P
H
-----
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
----
K
T
Q
L
N
S
-
S
S
L
Q
K
-
L
F
R
E
V
R
I
M
K
-
V
L
N
-
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
-----
D
---
A
D
---
M
N
---
I
----
K
--
I
A
D
F
---------------------------
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
--
D
-----
G
--
P
E
-------
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
---
D
--
N
L
K
E
--
L
-
R
E
-
R
V
L
R
G
--
K
--
Y
-
R
---
I
--
P
----
F
--
Y
----
M
S
T
D
--
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
-----
R
-----
G
-----
T
L
E
Q
I
M
K
D
R
W
M
N
VGHED
D
---------
E
--------------
L
K
P
Y
V
E
P
-
L
-
P
D
Y
--------
K
D
P
R
R
T
E
L
M
V
S
M
G
Y
T
R
E
E
I
Q
D
S
L
-
V
G
Q
R
Y
N
E
V
M
A
T
Y
L
L
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Blastp_CBE
60.46
44%
-133
- C3 -
-
5KZ7
7.9
-
MARK2_HUMAN
A:
[30-343]
-----
P
H
-----
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
----
K
T
Q
L
N
S
-
S
S
L
Q
K
-
L
F
R
E
V
R
I
M
K
-
V
L
N
-
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
-----
D
---
A
D
---
M
N
---
I
----
K
--
I
A
D
F
---------------------------
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
--
D
-----
G
--
P
E
-------
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
---
D
--
N
L
K
E
--
L
-
R
E
-
R
V
L
R
G
--
K
--
Y
-
R
---
I
--
P
----
F
--
Y
----
M
S
T
D
--
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
-----
R
-----
G
-----
T
L
E
Q
I
M
K
D
R
W
M
N
VGHED
D
---------
E
--------------
L
K
P
Y
V
E
P
-
L
-
P
D
Y
--------
K
D
P
R
R
T
E
L
M
V
S
M
G
Y
T
R
E
E
I
Q
D
S
L
-
V
G
Q
R
Y
N
E
V
M
A
T
Y
L
L
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Blastp_CBE
59.95
42%
-128
- C3 -
-
5ES1
8.8
-
MARK4_HUMAN
A:
[12-325]
-----
P
H
-----
V
G
N
Y
R
L
L
R
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
R
E
V
A
I
K
I
I
D
----
K
T
Q
L
N
P
-
S
S
L
Q
K
-
L
F
R
E
V
R
I
M
K
-
G
L
N
-
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
A
G
E
V
F
D
Y
L
V
S
H
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
H
Y
C
H
Q
K
N
I
V
H
R
D
L
K
A
E
N
L
L
---
L
-----
D
---
A
E
---
A
N
---
I
----
K
--
I
A
D
F
G
F
S
----
N
--------------------
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-----
G
--
P
E
-------
V
D
I
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
---
D
G
H
N
L
K
E
--
L
-
R
E
-
R
V
L
R
G
--
K
--
Y
-
R
---
V
--
P
----
F
--
Y
----
M
S
T
D
--
C
E
S
I
L
R
R
F
L
V
L
N
P
A
K
-----
R
-----
C
-----
T
L
E
Q
I
M
K
D
K
W
I
N
IGYEG
E
---------
E
--------------
L
K
P
Y
T
E
P
-
E
E
D
F
G
D
T
K
R
-
I
--------
E
V
M
V
G
M
G
Y
T
R
E
E
I
K
E
S
L
T
S
-
Q
K
Y
N
E
V
T
A
T
Y
L
L
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Blastp_CBE
59.39
44%
-127
- C3 -
-
5KZ8
7.8
-
MARK2_HUMAN
A:
[30-343]
-----
P
H
-----
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
----
K
T
Q
L
N
S
-
S
S
L
Q
K
-
L
F
R
E
V
R
I
M
K
-
V
L
N
-
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
-----
D
---
A
D
---
M
N
---
I
----
K
--
I
A
D
F
G
-------------------------
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-----
G
--
P
E
-------
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
---
D
G
Q
N
L
K
E
--
L
-
R
E
-
R
V
L
R
G
--
K
--
Y
-
R
---
I
--
P
----
F
--
Y
----
M
S
T
D
--
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
-----
R
-----
G
-----
T
L
E
Q
I
M
K
D
R
W
M
N
VGHED
D
---------
E
--------------
L
K
P
Y
V
E
P
-
L
-
P
D
Y
--------
K
D
P
R
R
T
E
L
M
V
S
M
G
Y
T
R
E
E
I
Q
D
S
L
-
V
G
Q
R
Y
N
E
V
M
A
T
Y
L
L
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Blastp_CBE
59.19
44%
-127
- C3 -
-
5KZ8
7.5
-
MARK2_HUMAN
B:
[30-343]
-----
P
H
-----
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
----
K
T
Q
L
N
S
-
S
S
L
Q
K
-
L
F
R
E
V
R
I
M
K
-
V
L
N
-
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
-----
D
---
A
D
---
M
N
---
I
----
K
--
I
A
D
F
---------------------------
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-----
G
--
P
E
-------
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
---
D
G
Q
N
L
K
E
--
L
-
R
E
-
R
V
L
R
G
--
K
--
Y
-
R
---
I
--
P
----
F
--
Y
----
M
S
T
D
--
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
-----
R
-----
G
-----
T
L
E
Q
I
M
K
D
R
W
M
N
VGHED
D
---------
E
--------------
L
K
P
Y
V
E
P
-
L
-
P
D
Y
--------
K
D
P
R
R
T
E
L
M
V
S
M
G
Y
T
R
E
E
I
Q
D
S
L
-
V
G
Q
R
Y
N
E
V
M
A
T
Y
L
L
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
571
HHSearch
58.74
41%
-131
- C3 -
-
5K00
10.8
-
MELK_HUMAN
A:
[4-326]
---------
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
L
G
--
S
D
L
P
R
-
I
K
T
E
I
E
A
L
K
-
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
----
K
--
L
I
D
F
G
L
C
----
A
K
-
P
-----------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
N
V
M
A
--
L
-
Y
K
-
K
I
M
R
G
--
K
--
Y
-
D
---
V
--
P
----
K
--
W
----
L
S
P
S
--
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
---------
D
--------------
Y
N
Y
P
V
E
W
-
Q
S
K
N
-
P
F
I
H
-
L
--
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
-
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
Blastp_CBE
57.84
46%
-141
- C3 -
-
5MAI
7.8
-
MELK_HUMAN
A:
[9-291]
------------
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
L
G
S
--
D
L
P
R
-
I
K
T
E
I
E
A
L
K
-
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
----
K
--
L
I
D
F
----------------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
N
V
M
A
--
L
-
Y
K
-
K
I
M
R
G
--
K
--
Y
-
D
---
V
--
P
----
K
--
W
----
L
S
P
S
--
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
---------
D
-----------------
Y
N
Y
P
V
E
W
Q
S
K
N
P
--H
L
--
D
D
D
C
V
T
E
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
Blastp_CBE
57.60
45%
-142
- C3 -
-
4UMQ
6.0
-
MELK_HUMAN
A:
[28-310]
------------
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
L
G
S
--
D
L
P
R
-
I
K
T
E
I
E
A
L
K
-
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
----
K
--
L
I
D
F
G
L
------------------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
T
A
A
A
--
L
-
V
A
-
K
I
M
R
G
--
K
--
Y
-
D
---
V
--
P
----
K
--
W
----
L
S
P
S
--
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
---------
D
-----------------
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
--
D
D
D
C
V
T
E
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
Blastp_CBE
57.35
44%
-121
- C3 -
-
5EAK
8.5
-
MARK2_HUMAN
B:
[15-325]
-------------
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
----
K
T
Q
L
N
S
-
S
S
L
Q
K
-
L
F
R
E
V
R
I
M
K
-
V
L
N
-
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
-----
D
---
A
D
---
M
N
---
I
----
K
--
I
A
D
F
G
------------------------
F
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-----
G
--
P
E
-------
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
---
D
G
Q
N
L
K
E
--
L
-
R
E
-
R
V
L
R
G
--
K
--
Y
-
R
---
I
--
P
----
F
--
Y
----
M
S
T
D
--
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
-----
R
-----
G
-----
T
L
E
Q
I
M
K
D
R
W
M
N
VGHED
D
---------
E
--------------
L
K
P
Y
V
E
P
-
L
-
P
D
Y
--------
K
D
P
R
R
T
E
L
M
V
S
M
G
Y
T
R
E
E
I
Q
D
S
L
-
V
G
Q
R
Y
N
E
V
M
A
T
Y
L
L
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Blastp_CBE
57.16
44%
-115
- C3 -
-
5EAK
8.0
-
MARK2_HUMAN
A:
[11-325]
----
Q
P
H
-----
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
----
K
T
Q
L
N
S
-
S
S
L
Q
K
-
L
F
R
E
V
R
I
M
K
-
V
L
N
-
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
-----
D
---
A
D
---
M
N
---
I
----
K
--
I
A
D
F
G
F
S
----------------------
F
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-----
G
--
P
E
-------
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
---
D
G
Q
N
L
K
E
--
L
-
R
E
-
R
V
L
R
G
--
K
--
Y
-
R
---
I
--
P
----
F
--
Y
----
M
S
T
D
--
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
-----
R
-----
G
-----
T
L
E
Q
I
M
K
D
R
W
M
N
VGHED
D
---------
E
--------------
L
K
P
Y
V
E
P
-
L
-
P
D
Y
--------
K
D
P
R
R
T
E
L
M
V
S
M
G
Y
T
R
E
E
I
Q
D
S
L
-
V
G
Q
R
Y
N
E
V
M
A
T
Y
L
L
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
Blastp_CBE
56.88
45%
-141
- C3 -
-
4UMT
10.2
-
MELK_HUMAN
A:
[28-310]
------------
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
L
G
S
--
D
L
P
R
-
I
K
T
E
I
E
A
L
K
-
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
----
K
--
L
I
D
F
G
L
------------------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
T
A
A
A
--
L
-
V
A
-
K
I
M
R
G
--
K
--
Y
-
D
---
V
--
P
----
K
--
W
----
L
S
P
S
--
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
---------
D
-----------------
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
--
D
D
D
C
V
T
E
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
Blastp_CBE
56.83
46%
-133
- C3 -
-
5MAH
6.2
-
MELK_HUMAN
A:
[9-291]
------------
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
L
G
S
--
D
L
P
R
-
I
K
T
E
I
E
A
L
K
-
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
----
K
--
L
I
D
F
G
L
C
----
A
K
-------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
--
L
-----
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
N
V
M
A
--
L
-
Y
K
-
K
I
M
R
G
--
K
--
Y
-
D
---
V
--
P
----
K
--
W
----
L
S
P
S
--
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
---------
D
-----------------
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
--
D
D
D
C
V
T
E
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
Blastp_CBE
56.83
46%
-132
- C3 -
-
5TWL
8.0
-
MELK_HUMAN
A:
[9-291]
------------
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
L
G
S
--
D
L
P
R
-
I
K
T
E
I
E
A
L
K
-
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
----
K
--
L
I
D
F
G
L
------------------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
N
V
M
A
--
L
-
Y
K
-
K
I
M
R
G
--
K
--
Y
-
D
---
V
--
P
----
K
--
W
----
L
S
P
S
--
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
---------
D
-----------------
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
--
D
D
D
C
V
T
E
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
Blastp_CBE
56.61
47%
-146
- C3 -
-
4CQG
8.6
-
MELK_MOUSE
A:
[8-266]
------------
L
K
Y
Y
E
L
Y
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
V
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
A
L
G
S
--
D
L
P
R
-
V
K
T
E
I
D
A
L
K
-
S
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
K
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
L
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
N
---
H
K
---
L
----
K
--
L
I
D
F
G
L
C
----
A
K
-----------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
----------
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
N
V
M
A
--
L
-
Y
K
-
K
I
M
R
G
--
K
--
Y
-
E
---
V
--
P
----
K
--
W
----
L
S
P
S
--
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
R
N
L
L
N
H
P
W
V
M
-----
Q
---------
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
Blastp_CBE
56.50
45%
-144
- C3 -
-
4UMR
5.8
-
MELK_HUMAN
A:
[28-310]
------------
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
L
G
S
--
D
L
P
R
-
I
K
T
E
I
E
A
L
K
-
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
----
K
--
L
I
D
F
G
L
------------------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
T
A
A
A
--
L
-
V
A
-
K
I
M
R
G
--
K
--
Y
-
D
---
V
--
P
----
K
--
W
----
L
S
P
S
--
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
---------
D
-----------------
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
--
D
D
D
C
V
T
E
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
Blastp_CBE
56.46
47%
-144
- C3 -
-
4BFM
6.3
-
MELK_MOUSE
A:
[8-266]
------------
L
K
Y
Y
E
L
Y
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
V
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
A
L
G
S
--
D
L
P
R
-
V
K
T
E
I
D
A
L
K
-
S
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
K
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
L
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
N
---
H
K
---
L
----
K
--
L
I
D
F
G
L
C
----
A
K
-----------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
----------
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
N
V
M
A
--
L
-
Y
K
-
K
I
M
R
G
--
K
--
Y
-
E
---
V
--
P
----
K
--
W
----
L
S
P
S
--
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
R
N
L
L
N
H
P
W
V
M
-----
Q
---------
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
Blastp_CBE
56.42
46%
-134
- C3 -
-
4BKZ
5.3
-
MELK_HUMAN
A:
[9-291]
------------
L
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
L
-----
L
P
R
-
I
K
T
E
I
E
A
L
K
-
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
----
K
--
L
I
D
F
G
L
C
----
A
--------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
---------
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
N
V
M
A
--
L
-
Y
K
-
K
I
M
R
G
--
K
--
Y
-
D
---
V
--
P
----
K
--
W
----
L
S
P
S
--
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
---------
D
-----------------
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
--
D
D
D
C
V
T
E
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
Blastp_CBE
56.35
46%
-130
- C3 -
-
5TVT
8.7
-
MELK_HUMAN
A:
[9-291]
------------
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
L
G
S
--
D
L
P
R
-
I
K
T
E
I
E
A
L
K
-
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
----
K
--
L
I
D
F
G
L
C
----
A
K
------------------
G
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
N
V
M
A
--
L
-
Y
K
-
K
I
M
R
G
--
K
--
Y
-
D
---
V
--
P
----
K
--
W
----
L
S
P
S
--
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
---------
D
-----------------
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
--
D
D
D
C
V
T
E
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
Blastp_CBE
56.06
46%
-133
- C3 -
-
5M5A
8.4
-
MELK_HUMAN
A:
[9-291]
------------
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
L
G
S
--
D
L
P
R
-
I
K
T
E
I
E
A
L
K
-
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
----
K
--
L
I
D
F
G
L
C
----
A
--------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
--
L
-----
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
N
V
M
A
--
L
-
Y
K
-
K
I
M
R
G
--
K
--
Y
-
D
---
V
--
P
----
K
--
W
----
L
S
P
S
--
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
---------
D
-----------------
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
--
D
D
D
C
V
T
E
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
Blastp_CBE
56.04
46%
-130
- C3 -
-
5IH9
6.7
-
MELK_HUMAN
A:
[7-289]
------------
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
------
L
P
R
-
I
K
T
E
I
E
A
L
K
-
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
----
K
--
L
I
D
F
G
L
C
----
A
K
-------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
N
V
M
A
--
L
-
Y
K
-
K
I
M
R
G
--
K
--
Y
-
D
---
V
--
P
----
K
--
W
----
L
S
P
S
--
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
---------
D
-----------------
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
--
D
D
D
C
V
T
E
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
Blastp_CBE
55.89
45%
-136
- C3 -
-
4UMU
9.5
-
MELK_HUMAN
A:
[28-310]
------------
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
L
G
S
--
D
L
P
R
-
I
K
T
E
I
E
A
L
K
-
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
----
K
--
L
I
D
F
G
L
------------------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
T
A
A
A
--
L
-
V
A
-
K
I
M
R
G
--
K
--
Y
-
D
---
V
--
P
----
K
--
W
----
L
S
P
S
--
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
---------
D
-----------------
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
--
D
D
D
C
V
T
E
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
Blastp_CBE
55.83
46%
-141
- C3 -
-
5TWZ
5.7
-
MELK_HUMAN
A:
[9-291]
------------
L
K
Y
Y
E
L
H
E
T
I
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
L
G
S
--
D
L
P
R
-
I
K
T
E
I
E
A
L
K
-
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
----
K
--
L
I
D
F
G
--------------------------
G
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
N
V
M
A
--
L
-
Y
K
-
K
I
M
R
G
--
K
--
Y
-
D
---
V
--
P
----
K
--
W
----
L
S
P
S
--
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
---------
D
-----------------
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
--
D
D
D
C
V
T
E
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
Blastp_CBE
55.76
46%
-138
- C3 -
-
5IHC
6.7
-
MELK_HUMAN
A:
[7-289]
------------
L
K
Y
Y
E
L
H
E
T
I
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
L
G
S
--
D
L
P
R
-
I
K
T
E
I
E
A
L
K
-
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
----
K
--
L
I
D
F
---------------------------
G
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
N
V
M
A
--
L
-
Y
K
-
K
I
M
R
G
--
K
--
Y
-
D
---
V
--
P
----
K
--
W
----
L
S
P
S
--
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
---------
D
-----------------
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
--
D
D
D
C
V
T
E
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
Blastp_CBE
55.58
46%
-134
- C3 -
-
5IHA
6.9
-
MELK_HUMAN
A:
[7-289]
------------
L
K
Y
Y
E
L
H
E
T
I
G
----
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
L
-------
R
-
I
K
T
E
I
E
A
L
K
-
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
----
K
--
L
I
D
F
G
L
C
----
A
K
-------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
N
V
M
A
--
L
-
Y
K
-
K
I
M
R
G
--
K
--
Y
-
D
---
V
--
P
----
K
--
W
----
L
S
P
S
--
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
---------
D
-----------------
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
--
D
D
D
C
V
T
E
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
Blastp_CBE
55.42
46%
-133
- C3 -
-
5IH8
6.5
-
MELK_HUMAN
A:
[7-289]
------------
L
K
Y
Y
E
L
H
E
T
I
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
-----
D
L
P
R
-
I
K
T
E
I
E
A
L
K
-
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
----
K
--
L
I
D
F
G
L
C
----
A
K
-------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
N
V
M
A
--
L
-
Y
K
-
K
I
M
R
G
--
K
--
Y
-
D
---
V
--
P
----
K
--
W
----
L
S
P
S
--
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
---------
D
-----------------
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
--
D
D
D
C
V
T
E
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
Blastp_CBE
55.38
46%
-130
- C3 -
-
4BL1
6.5
-
MELK_HUMAN
A:
[9-291]
------------
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
L
-----
L
P
R
-
I
K
T
E
I
E
A
L
K
-
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
----
K
--
L
I
D
F
G
L
C
----
A
K
-------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
--------
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
N
V
M
A
--
L
-
Y
K
-
K
I
M
R
G
--
K
--
Y
-
D
---
V
--
P
----
K
--
W
----
L
S
P
S
--
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
---------
D
-----------------
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
--
D
D
D
C
V
T
E
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
Blastp_CBE
55.02
46%
-136
- C3 -
-
5TWY
5.9
-
MELK_HUMAN
A:
[9-291]
------------
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
-----
D
L
P
R
-
I
K
T
E
I
E
A
L
K
-
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
----
K
--
L
I
D
F
G
L
------------------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
G
K
--------
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
N
V
M
A
--
L
-
Y
K
-
K
I
M
R
G
--
K
--
Y
-
D
---
V
--
P
----
K
--
W
----
L
S
P
S
--
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
---------
D
-----------------
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
--
D
D
D
C
V
T
E
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
Blastp_CBE
54.74
46%
-132
- C3 -
-
4BKY
8.0
-
MELK_HUMAN
A:
[9-291]
------------
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
L
----
D
L
P
R
-
I
K
T
E
I
E
A
L
K
-
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
----
K
--
L
I
D
F
G
L
C
----
A
--------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
--------
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
N
V
M
A
--
L
-
Y
K
-
K
I
M
R
G
--
K
--
Y
-
D
---
V
--
P
----
K
--
W
----
L
S
P
S
--
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
---------
D
-----------------
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
--
D
D
D
C
V
T
E
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
Blastp_CBE
54.36
46%
-126
- C3 -
-
6GVX
6.8
-
MELK_HUMAN
B:
[12-294]
------------
L
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
--
S
--
D
L
P
R
-
I
K
T
E
I
E
A
L
K
-
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
----
K
--
L
I
D
F
G
L
C
----
A
K
-
P
----------------
G
S
L
A
Y
A
A
P
E
L
I
Q
G
---------
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
N
V
M
A
--
L
-
Y
K
-
K
I
M
R
G
--
K
--
Y
-
D
---
V
--
P
----
K
--
W
----
L
S
P
S
--
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
---------
D
-----------------
Y
N
Y
P
-
V
E
W
Q
S
K
N
P
F
-
I
HL
D
D
D
C
V
T
E
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
Blastp_CBE
54.34
46%
-131
- C3 -
-
5MAG
6.6
-
MELK_HUMAN
A:
[9-291]
------------
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
-
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
L
----
D
L
P
R
-
I
K
T
E
I
E
A
L
K
-
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
----
K
--
L
I
D
F
G
L
C
----
A
K
-------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
--
L
-----
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
N
V
M
A
--
L
-
Y
K
-
K
I
M
R
G
--
K
--
Y
-
D
---
V
--
P
----
K
--
W
----
L
S
P
S
--
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
---------
D
-----------------
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
--
D
D
D
C
V
T
E
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
Blastp_CBE
54.34
46%
-128
- C3 -
-
5K00
10.8
-
MELK_HUMAN
A:
[7-289]
------------
L
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
L
G
S
--
D
L
P
R
-
I
K
T
E
I
E
A
L
K
-
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
----
K
--
L
I
D
F
G
L
C
----
A
K
-
P
-----------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
N
V
M
A
--
L
-
Y
K
-
K
I
M
R
G
--
K
--
Y
-
D
---
V
--
P
----
K
--
W
----
L
S
P
S
--
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
---------
D
-----------------
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
--
D
D
D
C
V
T
E
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
Blastp_CBE
54.05
46%
-140
- C3 -
-
5TX3
3.9
-
MELK_HUMAN
A:
[12-294]
------------
L
K
Y
Y
E
L
H
E
T
I
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
-----------
I
K
T
E
I
E
A
L
K
-
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
----
K
--
L
I
D
F
G
L
-------------------------
G
S
L
A
Y
A
A
P
E
L
I
Q
G
K
--------
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
N
V
M
A
--
L
-
Y
K
-
K
I
M
R
G
--
K
--
Y
-
D
---
V
--
P
----
K
--
W
----
L
S
P
S
--
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
---------
D
-----------------
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
--
D
D
D
C
V
T
E
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
Blastp_CBE
53.94
46%
-128
- C3 -
-
5MAF
6.6
-
MELK_HUMAN
A:
[9-291]
------------
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
L
----
D
L
P
R
-
I
K
T
E
I
E
A
L
K
-
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
----
K
--
L
I
D
F
G
L
C
----
A
K
-------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
--
L
-----
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
N
V
M
A
--
L
-
Y
K
-
K
I
M
R
G
--
K
--
Y
-
D
---
V
--
P
----
K
--
W
----
L
S
P
S
--
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
---------
D
-----------------
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
--
D
D
D
C
V
T
E
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
Blastp_CBE
53.92
46%
-134
- C3 -
-
5TWY
6.4
-
MELK_HUMAN
B:
[9-291]
------------
L
K
Y
Y
E
L
H
E
T
I
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
------
D
L
P
R
-
I
K
T
E
I
E
A
L
K
-
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
----
K
--
L
I
D
F
G
L
C
--------------------------
L
A
Y
A
A
P
E
L
I
Q
G
K
--------
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
N
V
M
A
--
L
-
Y
K
-
K
I
M
R
G
--
K
--
Y
-
D
---
V
--
P
----
K
--
W
----
L
S
P
S
--
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
---------
D
-----------------
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
--
D
D
D
C
V
T
E
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
Blastp_CBE
53.64
46%
-139
- C3 -
-
5TX3
8.0
-
MELK_HUMAN
B:
[12-294]
------------
L
K
Y
Y
E
L
H
E
T
I
G
-----
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
-------------
K
T
E
I
E
A
L
K
-
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
---
E
Y
---
H
K
---
L
----
K
--
L
I
D
----------------------------
G
S
L
A
Y
A
A
P
E
L
I
Q
G
---
L
-----
G
--
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
N
V
M
A
--
L
-
Y
K
-
K
I
M
R
G
--
K
--
Y
-
D
---
V
--
P
----
K
--
W
----
L
S
P
S
--
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
-----
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
-----
Q
---------
D
-----------------
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
--
D
D
D
C
V
T
E
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
553
Blastp_CBE
52.39
31%
-134
- C3 -
-
2WTW
8.1
-
AURKA_HUMAN
A:
[15-264]
---------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
----
K
A
Q
L
E
K
A
G
V
E
H
Q
-
L
R
R
E
V
E
I
Q
S
-
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
R
G
E
V
Y
K
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
-----
G
---
S
A
---
G
E
---
L
----
K
--
I
A
D
F
G
W
S
-----
V
-
H
---
A
P
S
---------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
------
D
--
E
K
-------
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
---
E
A
N
T
Y
Q
E
--
T
-
Y
K
-
R
I
S
R
V
--
E
--
F
-
T
---
F
--
P
----
D
--
F
----
V
T
E
G
--
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
-----
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
394
Blastp_CBE
52.31
35%
-123
- C3 -
-
2UZT
6.6
-
KAPCA_BOVIN
A:
[34-283]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
--
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
-----
F
GNLKD
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
392
Blastp_CBE
52.23
35%
-115
- C3 -
-
2UZV
7.0
-
KAPCA_BOVIN
A:
[34-283]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
--
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
-----
F
GNLKD
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
387
Blastp_CBE
51.90
35%
-121
- C3 -
-
2OH0
7.1
-
KAPCA_BOVIN
E:
[49-298]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
--
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
391
Blastp_CBE
51.33
35%
-117
- C3 -
-
2UZW
6.0
-
KAPCA_BOVIN
E:
[34-283]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
--
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
-----
F
GNLKD
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
393
Blastp_CBE
51.25
35%
-122
- C3 -
-
2UZU
6.0
-
KAPCA_BOVIN
E:
[34-283]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
--
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
-----
F
GNLKD
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
388
Blastp_CBE
51.05
35%
-121
- C3 -
-
2F7Z
7.6
-
KAPCA_BOVIN
E:
[49-298]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
--
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Blastp_CBE
51.03
44%
-67
- C3 -
-
4CZT
5.1
-
CIPKN_ARATH
D:
[4-294]
------
H
S
G
R
T
R
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
----
K
E
K
V
L
K
N
K
M
I
A
Q
-
I
K
R
E
I
S
T
M
K
-
L
I
K
-
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
-----
D
---
A
N
---
G
A
---
L
----
K
--
V
S
D
F
G
L
S
ALPQ
Q
V
-
R
---
E
D
G
----
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
-----
G
--
A
K
-------
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
---
E
D
S
N
L
T
S
--
L
-
Y
K
-
K
I
F
K
A
--
E
--
F
-
T
---
C
--
P
----
P
--
W
----
F
S
A
S
--
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
-----
R
-----
I
-----
T
F
A
E
V
I
E
N
E
W
F
K
-----
K
--------------------------
G
Y
K
A
P
-
K
F
E
N
A
D
V
S
L
-
D
--
D
V
D
A
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
390
Blastp_CBE
50.94
35%
-117
- C3 -
-
2F7E
7.3
-
KAPCA_BOVIN
E:
[49-298]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
--
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
Blastp_CBE
50.80
44%
-71
- C3 -
-
4CZU
4.6
-
CIPKN_ARATH
D:
[4-294]
------
H
S
G
R
T
R
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
----
K
E
K
V
L
K
N
K
M
I
A
Q
-
I
K
R
E
I
S
T
M
K
-
L
I
K
-
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
-----
D
---
A
N
---
G
A
---
L
----
K
--
V
S
D
F
G
L
S
ALPQ
Q
V
-
R
---
E
D
G
----
L
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
-----
G
--
A
K
-------
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
---
E
D
S
N
L
T
S
--
L
-
Y
K
-
K
I
F
K
A
--
E
--
F
-
T
---
C
--
P
----
P
--
W
----
F
S
A
S
--
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
-----
R
-----
I
-----
T
F
A
E
V
I
E
N
E
W
F
K
-----
K
--------------------------
G
Y
K
A
P
-
K
F
E
N
A
D
V
S
L
-
D
--
D
V
D
A
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
386
Blastp_CBE
50.68
35%
-116
- C3 -
-
2OJF
6.5
-
KAPCA_BOVIN
E:
[49-298]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
--
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
389
Blastp_CBE
50.28
35%
-109
- C3 -
-
2F7X
7.4
-
KAPCA_BOVIN
E:
[49-298]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
--
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
Blastp_CBE
50.23
44%
-66
- C3 -
-
4CZT
2.3
-
CIPKN_ARATH
A:
[4-290]
------
H
S
G
R
T
R
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
----
K
E
K
V
L
K
N
K
M
I
A
Q
-
I
K
R
E
I
S
T
M
K
-
L
I
K
-
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
-----
D
---
A
N
---
G
A
---
L
----
K
--
V
S
D
F
G
L
S
ALPQ
Q
V
-
R
---
E
D
G
----
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
-----
G
--
A
K
-------
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
---
E
D
S
N
L
T
S
--
L
-
Y
K
-
K
I
F
K
A
--
E
--
F
-
T
---
C
--
P
----
P
--
W
----
F
S
A
S
--
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
-----
R
-----
I
-----
T
F
A
E
V
I
E
N
E
W
F
K
-----
K
--------------------------
G
Y
K
A
P
-
K
F
E
N
--
V
S
L
-
D
--
D
V
D
A
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Blastp_CBE
49.93
44%
-71
- C3 -
-
4CZU
5.2
-
CIPKN_ARATH
A:
[4-290]
------
H
S
G
R
T
R
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
----
K
E
K
V
L
K
N
K
M
I
A
Q
-
I
K
R
E
I
S
T
M
K
-
L
I
K
-
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
-----
D
---
A
N
---
G
A
---
L
----
K
--
V
S
D
F
G
L
S
ALPQ
Q
V
-
R
---
E
D
G
----
L
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
-----
G
--
A
K
-------
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
---
E
D
S
N
L
T
S
--
L
-
Y
K
-
K
I
F
K
A
--
E
--
F
-
T
---
C
--
P
----
P
--
W
----
F
S
A
S
--
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
-----
R
-----
I
-----
T
F
A
E
V
I
E
N
E
W
F
K
-----
K
--------------------------
G
Y
K
A
P
-
K
F
E
N
------
D
--
D
V
D
A
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Blastp_CBE
49.52
44%
-74
- C3 -
-
4CZT
4.9
-
CIPKN_ARATH
C:
[10-290]
------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
----
K
E
K
V
L
K
N
K
M
I
A
Q
-
I
K
R
E
I
S
T
M
K
-
L
I
K
-
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
-----
D
---
A
N
---
G
A
---
L
----
K
--
V
S
D
F
G
L
S
ALPQ
Q
V
-
R
---
E
D
G
----
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
-----
G
--
A
K
-------
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
---
E
D
S
N
L
T
S
--
L
-
Y
K
-
K
I
F
K
A
--
E
--
F
-
T
---
C
--
P
----
P
--
W
----
F
S
A
S
--
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
-----
R
-----
I
-----
T
F
A
E
V
I
E
N
E
W
F
K
-----
K
--------------------------
G
Y
K
A
P
-
K
F
E
N
A
D
V
S
L
-
D
--
D
V
D
A
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
225
Blastp_CBE
49.23
37%
-83
- C3 -
-
6AYW
7.3
-
KCC2D_HUMAN
A:
[15-275]
---------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
----
T
K
K
L
S
A
R
D
H
-
Q
K
-
L
E
R
E
A
R
I
C
R
-
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
A
---
S
K
---
S
K
---
G
AAV-
K
--
L
A
D
F
G
L
A
I---
E
V
-
Q
---
G
D
Q
---
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
-----
K
--
P
--------
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
---
W
D
E
D
Q
H
R
--
L
-
Y
Q
-
Q
I
K
A
G
--
A
--
Y
-
D
---
F
--
P
SPEW
D
--
T
----
V
T
P
E
--
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
-----
R
-----
I
-----
T
A
S
E
A
L
K
H
P
W
I
C
-----
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
227
Blastp_CBE
49.15
37%
-86
- C3 -
-
5VLO
8.4
-
KCC2D_HUMAN
A:
[15-275]
---------------
Y
Q
L
F
E
E
L
G
---
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
----
T
K
K
L
S
A
R
D
H
-
Q
K
-
L
E
R
E
A
R
I
C
R
-
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
A
---
S
K
---
S
K
---
G
AAV-
K
--
L
A
D
F
G
L
A
I---
E
V
-
Q
---
G
D
Q
---
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
-----
K
--
P
--------
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
---
W
D
E
D
Q
H
R
--
L
-
Y
Q
-
Q
I
K
A
G
--
A
--
Y
-
D
---
F
--
P
SPEW
D
--
T
----
V
T
P
E
--
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
-----
R
-----
I
-----
T
A
S
E
A
L
K
H
P
W
I
C
-----
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
Blastp_CBE
49.15
44%
-72
- C3 -
-
4CZT
5.3
-
CIPKN_ARATH
B:
[4-290]
------
H
S
G
R
T
R
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
----
K
E
K
V
L
K
N
K
M
I
A
Q
-
I
K
R
E
I
S
T
M
K
-
L
I
K
-
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
-----
D
---
A
N
---
G
A
---
L
----
K
--
V
S
D
F
G
L
S
ALPQ
Q
V
-
R
---
E
D
G
----
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
-----
G
--
A
K
-------
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
---
E
D
S
N
L
T
S
--
L
-
Y
K
-
K
I
F
K
A
--
E
--
F
-
T
---
C
--
P
----
P
--
W
----
F
S
A
S
--
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
-----
R
-----
I
-----
T
F
A
E
V
I
E
N
E
W
F
K
-----
K
--------------------------
G
Y
K
A
P
-
K
F
E
-------
D
--
D
V
D
A
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
564
HHSearch
49.03
34%
-56
- C3 -
-
4CZT
5.4
-
CIPKN_ARATH
D:
[5-306]
-------
S
G
R
T
R
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
----
K
E
K
V
L
K
N
K
M
I
A
Q
-
I
K
R
E
I
S
T
M
K
-
L
I
K
-
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
-----
D
---
A
N
---
G
A
---
L
----
K
--
V
S
D
F
G
L
S
----
A
L
-
P
---
Q
Q
V
RED
G
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
-----
G
--
A
K
-------
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
---
E
D
S
N
L
T
S
--
L
-
Y
K
-
K
I
F
K
A
--
E
--
F
-
T
---
C
--
P
----
P
--
W
----
F
S
A
S
--
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
-----
R
-----
I
-----
T
F
A
E
V
I
E
N
E
W
F
K
-----
K
---------
G
--------------
Y
K
A
P
K
F
E
-
N
A
-
D
V
S
L
D
D
--------
V
D
A
I
F
D
D
S
----
N
L
V
V
E
R
--------------------
R
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
Blastp_CBE
48.93
44%
-66
- C3 -
-
4CZU
5.6
-
CIPKN_ARATH
B:
[4-290]
------
H
S
G
R
T
R
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
----
K
E
K
V
L
K
N
K
M
I
A
Q
-
I
K
R
E
I
S
T
M
K
-
L
I
K
-
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
-----
D
---
A
N
---
G
A
---
L
----
K
--
V
S
D
F
G
L
S
ALPQ
Q
V
-
R
---
E
D
G
----
L
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
-----
G
--
A
K
-------
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
---
E
D
S
N
L
T
S
--
L
-
Y
K
-
K
I
F
K
A
--
E
--
F
-
T
---
C
--
P
----
P
--
W
----
F
S
A
S
--
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
-----
R
-----
I
-----
T
F
A
E
V
I
E
N
E
W
F
K
-----
K
--------------------------
G
Y
K
A
P
-
K
F
E
-------
D
--
D
V
D
A
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
220
Blastp_CBE
48.92
37%
-81
- C3 -
-
6BAB
8.7
-
KCC2D_MOUSE
D:
[15-275]
---------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
----
T
K
K
L
S
A
R
D
H
-
Q
K
-
L
E
R
E
A
R
I
C
R
-
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
A
---
S
K
---
S
K
---
G
AAV-
K
--
L
A
D
F
G
L
A
I---
E
V
-
Q
---
G
D
Q
---
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
-----
K
--
P
--------
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
---
W
D
E
D
Q
H
R
--
L
-
Y
Q
-
Q
I
K
A
G
--
A
--
Y
-
D
---
F
--
P
SPEW
D
--
T
----
V
T
P
E
--
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
-----
R
-----
I
-----
T
A
S
E
A
L
K
H
P
W
I
C
-----
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
226
Blastp_CBE
48.67
37%
-83
- C3 -
-
5VLO
9.6
-
KCC2D_HUMAN
B:
[15-275]
---------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
----
T
K
K
L
S
A
R
D
H
-
Q
K
-
L
E
R
E
A
R
I
C
R
-
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
A
---
S
K
---
S
K
---
G
AAV-
K
--
L
A
D
F
G
L
A
I---
E
V
-
Q
---
G
D
Q
---
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
-----
K
--
P
--------
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
---
W
D
E
D
Q
H
R
--
L
-
Y
Q
-
Q
I
K
A
G
--
A
--
Y
-
D
---
F
--
P
SPEW
D
--
T
----
V
T
P
E
--
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
-----
R
-----
I
-----
T
A
S
E
A
L
K
H
P
W
I
C
-----
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
224
Blastp_CBE
48.43
37%
-82
- C3 -
-
6AYW
7.7
-
KCC2D_HUMAN
B:
[15-275]
---------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
----
T
K
K
L
S
A
R
D
H
-
Q
K
-
L
E
R
E
A
R
I
C
R
-
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
A
---
S
K
---
S
K
---
G
AAV-
K
--
L
A
D
F
G
L
A
I---
E
V
-
Q
---
G
D
Q
---
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
-----
K
--
P
--------
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
---
W
D
E
D
Q
H
R
--
L
-
Y
Q
-
Q
I
K
A
G
--
A
--
Y
-
D
---
F
--
P
SPEW
D
--
T
----
V
T
P
E
--
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
-----
R
-----
I
-----
T
A
S
E
A
L
K
H
P
W
I
C
-----
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
405
Blastp_CBE
48.36
38%
-103
- C3 -
-
5JZJ
6.7
-
B:
[38-294]
---------------
Y
K
V
G
R
T
I
G
D
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
I
K
----
K
S
K
C
R
G
K
E
H
M
---
I
Q
N
E
V
S
I
L
R
-
R
V
K
-
H
P
N
I
V
L
L
I
E
E
M
D
V
P
T
E
L
Y
L
V
M
E
L
V
K
G
G
D
L
F
D
A
I
T
S
T
N
K
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
L
L
---
V
-----
Y
---
E
H
---
Q
D
---
G
SKSL
K
--
L
G
D
F
G
L
A
----
T
I
-
V
----
D
G
---
P
-
L
Y
T
V
C
G
T
P
T
Y
V
A
P
E
I
I
A
E
T
G
Y
------
G
--
L
K
-------
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
R-----
E
V
----
L
-
F
D
-
Q
I
L
M
G
--
Q
--
V
-
D
---
F
--
P
SPYW
D
--
N
----
V
S
D
S
--
A
K
E
L
I
T
M
M
L
L
V
D
V
D
Q
-----
R
-----
F
-----
S
A
V
Q
V
L
E
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
174
Blastp_CBE
48.30
38%
-91
- C3 -
-
3BHH
4.9
-
KCC2B_HUMAN
A:
[6-266]
---------------
Y
Q
L
Y
E
D
I
G
----
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
I
N
----
T
K
K
L
S
A
R
D
H
-
Q
K
-
L
E
R
E
A
R
I
C
R
-
L
L
K
-
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
A
---
S
K
---
C
K
---
G
AAV-
K
--
L
A
D
F
G
L
A
I---
E
V
-
Q
---
G
D
Q
---
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
E
A
Y
G
-----
K
--
P
--------
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
---
W
D
E
D
Q
H
K
--
L
-
Y
Q
-
Q
I
K
A
G
--
A
--
Y
-
D
---
F
--
P
SPEW
D
--
T
----
V
T
P
E
--
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
-----
R
-----
I
-----
T
A
H
E
A
L
K
H
P
W
V
C
-----
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
222
Blastp_CBE
48.29
37%
-82
- C3 -
-
6BAB
8.5
-
KCC2D_MOUSE
B:
[15-275]
---------------
Y
Q
L
F
E
E
L
G
----
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
----
T
K
K
L
S
A
R
D
H
-
Q
K
-
L
E
R
E
A
R
I
C
R
-
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
A
---
S
K
---
S
K
---
G
AAV-
K
--
L
A
D
F
G
L
A
I---
E
V
-
Q
---
G
D
Q
---
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
-----
K
--
P
--------
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
---
W
D
E
D
Q
H
R
--
L
-
Y
Q
-
Q
I
K
A
G
--
A
--
Y
-
D
---
F
--
P
SPEW
D
--
T
----
V
T
P
E
--
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
-----
R
-----
I
-----
T
A
S
E
A
L
K
H
P
W
I
C
-----
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
Blastp_CBE
48.26
44%
-71
- C3 -
-
4CZU
5.1
-
CIPKN_ARATH
C:
[9-294]
-----------
R
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
----
K
E
K
V
L
K
N
K
M
I
A
Q
-
I
K
R
E
I
S
T
M
K
-
L
I
K
-
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
-----
D
---
A
N
---
G
A
---
L
----
K
--
V
S
D
F
G
L
S
ALPQ
Q
V
-
R
---
E
D
G
----
L
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
-----
G
--
A
K
-------
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
---
E
D
S
N
L
T
S
--
L
-
Y
K
-
K
I
F
K
A
--
E
--
F
-
T
---
C
--
P
----
P
--
W
----
F
S
A
S
--
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
-----
R
-----
I
-----
T
F
A
E
V
I
E
N
E
W
F
K
-----
K
--------------------------
G
Y
K
A
P
-
K
F
E
N
A
D
V
S
L
-
D
--
D
V
D
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
376
Blastp_CBE
48.06
38%
-93
- C3 -
-
5JZN
6.9
-
B:
[21-277]
---------------
Y
K
V
G
R
T
I
G
D
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
I
K
----
K
S
K
C
R
G
K
E
H
M
---
I
Q
N
E
V
S
I
L
R
-
R
V
K
-
H
P
N
I
V
L
L
I
E
E
M
D
V
P
T
E
L
Y
L
V
M
E
L
V
K
G
G
D
L
F
D
A
I
T
S
T
N
K
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
L
L
---
V
-----
Y
---
E
H
---
Q
D
---
G
SKSL
K
--
L
G
D
F
G
L
A
----
T
I
-
V
----
D
G
---
P
-
L
Y
T
V
C
G
T
P
T
Y
V
A
P
E
I
I
A
E
T
G
Y
------
G
--
L
K
-------
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
RGS--
Q
E
V
----
L
-
F
D
-
Q
I
L
M
G
--
Q
--
V
-
D
---
F
--
P
SPYW
D
--
N
----
V
S
D
S
--
A
K
E
L
I
T
M
M
L
L
V
D
V
D
Q
-----
R
-----
F
-----
S
A
V
Q
V
L
E
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
406
Blastp_CBE
48.00
38%
-94
- C3 -
-
5JZJ
6.9
-
DCLK1_HUMAN
A:
[38-294]
---------------
Y
K
V
G
R
T
I
G
D
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
I
K
----
K
S
K
C
R
G
K
E
H
M
---
I
Q
N
E
V
S
I
L
R
-
R
V
K
-
H
P
N
I
V
L
L
I
E
E
M
D
V
P
T
E
L
Y
L
V
M
E
L
V
K
G
G
D
L
F
D
A
I
T
S
T
N
K
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
L
L
---
V
-----
Y
---
E
H
---
Q
D
---
G
SKSL
K
--
L
G
D
F
G
L
A
----
T
I
-
V
----
D
G
---
P
-
L
Y
T
V
C
G
T
P
T
Y
V
A
P
E
I
I
A
E
T
G
Y
------
G
--
L
K
-------
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
RGS---
E
V
----
L
-
F
D
-
Q
I
L
M
G
--
Q
--
V
-
D
---
F
--
P
SPYW
D
--
N
----
V
S
D
S
--
A
K
E
L
I
T
M
M
L
L
V
D
V
D
Q
-----
R
-----
F
-----
S
A
V
Q
V
L
E
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
223
Blastp_CBE
47.87
37%
-78
- C3 -
-
6BAB
9.5
-
KCC2D_MOUSE
A:
[15-275]
---------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
----
T
K
K
L
S
A
R
D
H
-
Q
K
-
L
E
R
E
A
R
I
C
R
-
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
A
---
S
K
---
S
K
---
G
AAV-
K
--
L
A
D
F
G
L
A
I---
E
V
-
Q
---
G
D
Q
---
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
-----
K
--
P
--------
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
---
W
D
E
D
Q
H
R
--
L
-
Y
Q
-
Q
I
K
A
G
--
A
--
Y
-
D
---
F
--
P
SPEW
D
--
T
----
V
T
P
E
--
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
-----
R
-----
I
-----
T
A
S
E
A
L
K
H
P
W
I
C
-----
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
177
Blastp_CBE
47.73
38%
-79
- C3 -
-
5FG8
4.8
-
KCC2A_DROME
A:
[15-276]
--------------
N
Y
D
I
K
E
E
L
G
K
G
A
F
S
I
V
K
R
C
V
Q
K
S
T
G
F
E
F
A
A
K
I
I
N
----
T
K
K
L
T
A
R
D
F
-
Q
K
-
L
E
R
E
A
R
I
C
R
-
K
L
H
-
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
N
Y
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
F
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
N
G
V
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
A
---
S
K
---
A
K
---
G
AAV-
K
--
L
A
D
F
G
L
A
I---
E
V
-
Q
---
G
D
H
---
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
K
K
E
P
Y
------
G
--
K
S
-------
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
---
W
D
E
D
Q
H
R
--
L
-
Y
S
-
Q
I
K
A
G
--
A
--
Y
-
D
---
Y
--
P
SPEW
D
--
T
----
V
T
P
E
--
A
K
N
L
I
N
Q
M
L
T
V
N
P
N
K
-----
R
-----
I
-----
T
A
A
E
A
L
K
H
P
W
I
C
-----
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
424
Blastp_CBE
47.72
36%
-80
- C3 -
-
2V7O
6.5
-
KCC2G_HUMAN
A:
[33-293]
---------------
Y
Q
L
F
E
E
L
G
K
G
-
F
S
V
V
R
R
C
V
K
K
T
P
T
Q
E
Y
A
A
K
I
I
N
----
T
K
K
L
S
A
R
D
H
-
Q
K
-
L
E
R
E
A
R
I
C
R
-
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
H
Q
I
L
E
S
V
N
H
I
H
Q
H
D
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
A
---
S
K
---
C
K
---
G
AAV-
K
--
L
A
D
F
G
L
A
I---
E
V
-
Q
---
G
E
Q
---
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
-----
K
--
P
--------
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
---
W
D
E
D
Q
H
K
--
L
-
Y
Q
-
Q
I
K
A
G
--
A
--
Y
-
D
---
F
--
P
SPEW
D
--
T
----
V
T
P
E
--
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
-----
R
-----
I
-----
T
A
D
Q
A
L
K
H
P
W
V
C
-----
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
219
Blastp_CBE
47.58
37%
-84
- C3 -
-
5HU3
5.1
-
KCC2A_DROME
A:
[15-274]
--------------
N
Y
D
I
K
E
E
L
G
K
G
A
F
S
I
V
K
R
C
V
Q
K
S
T
G
F
E
F
A
A
K
I
I
N
----
T
K
K
L
T
A
R
D
F
-
Q
K
-
L
E
R
E
A
R
I
C
R
-
K
L
H
-
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
N
Y
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
F
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
N
G
V
V
H
R
N
L
K
P
E
N
L
L
---
L
-----
A
---
S
K
---
A
K
---
G
AAV-
K
--
L
A
D
F
G
L
A
I---
E
V
-
Q
---
G
D
H
---
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
K
K
E
P
Y
------
G
--
K
S
-------
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
---
W
D
E
D
Q
H
R
--
L
-
Y
S
-
Q
I
K
A
G
--
A
--
Y
-
D
---
Y
--
P
SPEW
D
--
T
----
V
T
P
E
--
A
K
N
L
I
N
Q
M
L
T
V
N
P
N
K
-----
R
-----
I
-----
T
A
A
E
A
L
K
H
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
377
Blastp_CBE
47.26
38%
-88
- C3 -
-
5JZN
6.0
-
DCLK1_HUMAN
A:
[21-277]
---------------
Y
K
V
G
R
T
I
G
D
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
I
K
----
K
S
K
C
R
G
K
E
H
M
---
I
Q
N
E
V
S
I
L
R
-
R
V
K
-
H
P
N
I
V
L
L
I
E
E
M
D
V
P
T
E
L
Y
L
V
M
E
L
V
K
G
G
D
L
F
D
A
I
T
S
T
N
K
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
L
L
---
V
-----
Y
---
E
H
---
Q
D
---
G
SKSL
K
--
L
G
D
F
G
L
A
----
T
I
-
V
----
D
G
---
P
-
L
Y
T
V
C
G
T
P
T
Y
V
A
P
E
I
I
A
E
T
G
Y
------
G
--
L
K
-------
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
RGS-
D
Q
E
V
----
L
-
F
D
-
Q
I
L
M
G
--
Q
--
V
-
D
---
F
--
P
SPYW
D
--
N
----
V
S
D
S
--
A
K
E
L
I
T
M
M
L
L
V
D
V
D
Q
-----
R
-----
F
-----
S
A
V
Q
V
L
E
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
229
Blastp_CBE
47.01
37%
-79
- C3 -
-
2VN9
6.8
-
KCC2D_HUMAN
A:
[6-266]
---------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
----
T
K
K
L
S
A
R
D
H
-
Q
K
-
L
E
R
E
A
R
I
C
R
-
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
A
---
S
K
---
S
K
---
G
AAV-
K
--
L
A
D
F
G
L
A
I---
E
V
-
Q
---
G
D
Q
---
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
-----
K
--
P
--------
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
---
W
D
E
D
Q
H
R
--
L
-
Y
Q
-
Q
I
K
A
G
--
A
--
Y
-
D
---
F
--
P
SPEW
D
--
T
----
V
T
P
E
--
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
-----
R
-----
I
-----
T
A
S
E
A
L
K
H
P
W
I
C
-----
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
567
HHSearch
46.98
34%
-57
- C3 -
-
4CZU
5.4
-
CIPKN_ARATH
B:
[5-295]
-------
S
G
R
T
R
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
----
K
E
K
V
L
K
N
K
M
I
A
Q
-
I
K
R
E
I
S
T
M
K
-
L
I
K
-
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
-----
D
---
A
N
---
G
A
---
L
----
K
--
V
S
D
F
G
L
S
----
A
L
-
P
---
Q
Q
V
RED
G
L
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
-----
G
--
A
K
-------
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
---
E
D
S
N
L
T
S
--
L
-
Y
K
-
K
I
F
K
A
--
E
--
F
-
T
---
C
--
P
----
P
--
W
----
F
S
A
S
--
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
-----
R
-----
I
-----
T
F
A
E
V
I
E
N
E
W
F
K
-----
K
---------
G
--------------
Y
K
A
P
K
F
E
--------------
D
-
D
-
V
D
A
I
F
D
D
S
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
256
Blastp_CBE
46.65
34%
-103
- C3 -
-
5M75
5.8
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
250
Blastp_CBE
46.61
34%
-97
- C3 -
-
5N7P
4.5
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
180
Blastp_CBE
46.61
36%
-64
- C3 -
-
3MWU
7.5
-
?
A:
[30-315]
---------------------
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
----
K
A
S
A
K
N
K
D
T
-
S
T
-
I
L
R
E
V
E
L
L
K
-
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
-----
E
---
S
K
EKD
C
D
---
I
----
K
--
I
I
D
F
G
L
S
----
T
C
-
F
---
Q
Q
N
-------
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
---
Y
G
K
N
E
Y
D
--
I
-
L
K
-
R
V
E
T
G
KY
A
--
F
-
D
---
L
--
P
----
Q
--
W
RT--
I
S
D
D
--
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
-----
R
-----
I
-----
T
A
T
Q
C
L
E
H
P
W
I
Q
-----
K
YSSETPTIS
D
--------------
L
P
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
178
Blastp_CBE
46.47
36%
-57
- C3 -
-
4Y5Q
5.0
-
?
A:
[30-315]
---------------------
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
----
K
A
S
A
K
N
K
D
T
-
S
T
-
I
L
R
E
V
E
L
L
K
-
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
-----
E
---
S
K
EKD
C
D
---
I
----
K
--
I
I
D
F
G
L
S
----
T
C
-
F
---
Q
Q
N
---
T
---
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
---
Y
G
K
N
E
Y
D
--
I
-
L
K
-
R
V
E
T
G
KY
A
--
F
-
D
---
L
--
P
----
Q
--
W
RT--
I
S
D
D
--
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
-----
R
-----
I
-----
T
A
T
Q
C
L
E
H
P
W
I
Q
-----
K
YSSETPTIS
D
--------------
L
P
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
176
Blastp_CBE
46.47
38%
-74
- C3 -
-
5H9B
5.8
-
KCC2A_DROME
A:
[15-276]
--------------
N
Y
D
I
K
E
E
L
G
K
G
A
F
S
I
V
K
R
C
V
Q
K
S
T
G
F
E
F
A
A
K
I
I
N
----
T
K
K
L
T
A
R
D
F
-
Q
K
-
L
E
R
E
A
R
I
C
R
-
K
L
H
-
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
N
Y
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
F
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
N
G
V
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
A
---
S
K
---
A
K
---
G
AAV-
K
--
L
A
D
F
G
L
A
I---
E
V
-
Q
---
G
D
H
---
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
K
K
E
P
Y
------
G
--
K
S
-------
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
---
W
D
E
D
Q
H
R
--
L
-
Y
S
-
Q
I
K
A
G
--
A
--
Y
-
D
---
Y
--
P
SPEW
D
--
T
----
V
T
P
E
--
A
K
N
L
I
N
Q
M
L
T
V
N
P
N
K
-----
R
-----
I
-----
T
A
A
E
A
L
K
H
P
W
I
C
-----
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
179
Blastp_CBE
46.30
36%
-65
- C3 -
-
3NCG
7.3
-
?
A:
[30-332]
---------------------
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
----
K
A
S
A
K
N
K
D
T
-
S
T
-
I
L
R
E
V
E
L
L
K
-
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
-----
E
---
S
K
EKD
C
D
---
I
----
K
--
I
I
D
F
G
L
S
----
T
C
-
F
---
Q
Q
N
---
T
-----
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
---
Y
G
K
N
E
Y
D
--
I
-
L
K
-
R
V
E
T
G
KY
A
--
F
-
D
---
L
--
P
----
Q
--
W
RT--
I
S
D
D
--
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
-----
R
-----
I
-----
T
A
T
Q
C
L
E
H
P
W
I
Q
-----
K
YSSETPTIS
D
--------------
L
P
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
249
Blastp_CBE
46.27
34%
-96
- C3 -
-
5N7U
3.5
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
264
Blastp_CBE
46.22
34%
-104
- C3 -
-
5LCU
5.4
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
156
Blastp_CBE
46.14
33%
-50
- C3 -
-
5JN2
7.1
-
?
A:
[75-397]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
----
R
--
I
I
D
F
G
L
S
----
T
H
-
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
G
A
N
E
Y
D
--
I
-
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
---
L
--
P
----
Q
--
W
KK--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
---------
Y
--------------
T
K
-------
V
P
S
L
D
N
A
I
-
L
--
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
262
Blastp_CBE
46.12
34%
-98
- C3 -
-
5M0C
4.3
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
259
Blastp_CBE
46.03
34%
-98
- C3 -
-
5M6V
6.3
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
221
Blastp_CBE
45.98
37%
-77
- C3 -
-
6BAB
9.4
-
KCC2D_MOUSE
C:
[15-275]
---------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
----
Q
E
Y
A
A
K
I
I
N
----
T
K
K
L
S
A
R
D
H
-
Q
K
-
L
E
R
E
A
R
I
C
R
-
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
A
---
S
K
---
S
K
---
G
AAV-
K
--
L
A
D
F
G
L
A
I---
E
V
-
Q
---
G
D
Q
---
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
-----
K
--
P
--------
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
---
W
D
E
D
Q
H
R
--
L
-
Y
Q
-
Q
I
K
A
G
--
A
--
Y
-
D
---
F
--
P
SPEW
D
--
T
----
V
T
P
E
--
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
-----
R
-----
I
-----
T
A
S
E
A
L
K
H
P
W
I
C
-----
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
253
Blastp_CBE
45.95
34%
-94
- C3 -
-
5N1E
3.9
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
258
Blastp_CBE
45.96
34%
-99
- C3 -
-
5M6Y
5.5
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
141
Blastp_CBE
45.95
33%
-51
- C3 -
-
3UPX
6.5
-
?
A:
[34-360]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
----
R
--
I
I
D
F
G
L
S
----
T
H
-
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
G
A
N
E
Y
D
--
I
-
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
---
L
--
P
----
Q
--
W
KK--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
---------
Y
--------------
T
K
-------
V
P
S
L
D
N
A
I
-
L
--
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
542
Blastp_CBE
45.88
36%
-93
- C3 -
-
3SOA
3.4
-
KCC2A_HUMAN
A:
[13-271]
---------------
Y
Q
L
F
E
E
L
G
K
G
--
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
M
I
I
N
----
T
K
K
L
S
A
R
D
H
-
Q
K
-
L
E
R
E
A
R
I
C
R
-
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
H
H
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
N
L
K
P
E
N
L
L
---
L
-----
A
---
S
K
---
L
K
---
G
AAV-
K
--
L
A
D
F
G
L
A
I---
E
V
-
E
---
G
E
Q
---
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
-----
K
--
P
--------
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
---
W
D
E
D
Q
H
R
--
L
-
Y
Q
-
Q
I
K
A
G
--
A
--
Y
-
D
---
F
--
P
SPEW
D
--
T
----
V
T
P
E
--
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
-----
R
-----
I
-----
T
A
A
E
A
L
K
H
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
165
Blastp_CBE
45.86
32%
-49
- C3 -
-
4MXA
5.3
-
?
A:
[34-354]
--------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
Y
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
----
R
--
I
I
D
F
G
L
S
----
T
H
-
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
G
A
N
E
Y
D
--
I
-
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
---
L
--
P
----
Q
--
W
KK--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
---------
Y
--------------
T
K
E
Q
I
S
V
-
D
V
P
S
L
D
N
A
I
-
L
--
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
254
Blastp_CBE
45.85
34%
-99
- C3 -
-
5N1D
4.5
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
142
Blastp_CBE
45.84
33%
-51
- C3 -
-
3T3V
4.3
-
?
A:
[34-352]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
----
R
--
I
I
D
F
G
L
S
----
T
H
-
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
G
A
N
E
Y
D
--
I
-
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
---
L
--
P
----
Q
--
W
KK--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
---------
Y
--------------
T
K
------
D
V
P
S
L
D
N
A
I
-
L
--
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
257
Blastp_CBE
45.80
34%
-103
- C3 -
-
5M71
5.2
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
157
Blastp_CBE
45.80
33%
-52
- C3 -
-
5JMS
6.2
-
?
A:
[75-399]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
----
R
--
I
I
D
F
G
L
S
----
T
H
-
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
G
A
N
E
Y
D
--
I
-
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
---
L
--
P
----
Q
--
W
KK--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
---------
Y
--------------
T
K
-------
V
P
S
L
D
N
A
I
-
L
--
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
144
Blastp_CBE
45.75
33%
-49
- C3 -
-
3SXF
7.6
-
?
A:
[34-358]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
----
R
--
I
I
D
F
G
L
S
----
T
H
-
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
G
A
N
E
Y
D
--
I
-
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
---
L
--
P
----
Q
--
W
KK--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
---------
Y
--------------
T
K
E
Q
I
S
V
-
D
V
P
S
L
D
N
A
I
-
L
--
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
126
Blastp_CBE
45.74
33%
-52
- C3 -
-
5W91
6.6
-
?
A:
[34-355]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
----
R
--
I
I
D
F
G
L
S
----
T
H
-
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
G
A
N
E
Y
D
--
I
-
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
---
L
--
P
----
Q
--
W
KK--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
---------
Y
--------------
T
K
-------
V
P
S
L
D
N
A
I
-
L
--
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
140
Blastp_CBE
45.72
33%
-53
- C3 -
-
3UPZ
4.3
-
?
A:
[34-347]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
----
R
--
I
I
D
F
G
L
S
----
T
H
-
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
G
A
N
E
Y
D
--
I
-
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
---
L
--
P
----
Q
--
W
KK--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
---------
Y
--------------
T
K
-------
V
P
S
L
D
N
A
I
-
L
--
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
115
Blastp_CBE
45.70
33%
-50
- C3 -
-
4IEB
4.8
-
?
A:
[57-371]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
---
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
M
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
----
R
--
I
I
D
F
G
L
S
----
T
H
-
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
G
A
N
E
Y
D
--
I
-
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
------
P
----
Q
--
W
KK--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
---------
Y
--------------
T
K
E
Q
I
S
V
-
D
V
P
S
L
D
N
A
I
-
L
--
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
291
Blastp_CBE
45.67
35%
-93
- C3 -
-
3L9L
7.9
-
KAPCA_HUMAN
A:
[49-298]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
143
Blastp_CBE
45.69
33%
-50
- C3 -
-
3T3U
6.3
-
?
A:
[34-358]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
----
R
--
I
I
D
F
G
L
S
----
T
H
-
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
G
A
N
E
Y
D
--
I
-
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
---
L
--
P
----
Q
--
W
KK--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
---------
Y
--------------
T
K
E
Q
I
S
V
-
D
V
P
S
L
D
N
A
I
-
L
--
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
325
Blastp_CBE
45.68
35%
-102
- C3 -
-
4NTT
4.3
-
KAPCA_MOUSE
B:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
251
Blastp_CBE
45.67
34%
-98
- C3 -
-
5N32
4.9
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
-
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
166
Blastp_CBE
45.66
32%
-49
- C3 -
-
4MX9
5.1
-
?
A:
[34-354]
--------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
Y
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
----
R
--
I
I
D
F
G
L
S
----
T
H
-
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
G
A
N
E
Y
D
--
I
-
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
---
L
--
P
----
Q
--
W
KK--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
---------
Y
--------------
T
K
E
Q
I
S
V
-
D
V
P
S
L
D
N
A
I
-
L
--
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
111
Blastp_CBE
45.61
38%
-98
- C3 -
-
2JC6
5.4
-
KCC1D_HUMAN
A:
[24-283]
---------------
F
E
F
K
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
P
----
K
K
A
-------
S
S
-
I
E
N
E
I
A
V
L
R
-
K
I
K
-
H
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
---
Y
YSQ--
D
---
E
E
---
S
K
---
I
----
M
--
I
S
-------------------------------
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
-----
K
--
A
--------
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
---
Y
D
E
N
D
S
K
--
L
-
F
E
-
Q
I
L
K
A
--
E
--
Y
-
E
---
F
DS
P
----
Y
--
W
DD--
I
S
D
S
--
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
-----
R
-----
Y
-----
T
C
E
Q
A
A
R
H
P
W
I
A
-----
G
---------
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
181
Blastp_CBE
45.57
36%
-62
- C3 -
-
3IGO
5.8
-
?
A:
[30-310]
---------------------
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
----
K
A
S
A
K
N
K
-
T
-
S
T
-
I
L
R
E
V
E
L
L
K
-
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
-----
E
---
S
K
EKD
C
D
---
I
----
K
--
I
I
D
F
G
L
S
----
T
C
-
F
---
Q
Q
N
---
T
-------
T
A
Y
Y
I
A
P
E
V
L
R
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
---
Y
G
K
N
E
Y
D
--
I
-
L
K
-
R
V
E
T
G
KY
A
--
F
-
D
---
L
--
P
----
Q
--
W
RT--
I
S
D
D
--
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
-----
R
-----
I
-----
T
A
T
Q
C
L
E
H
P
W
I
Q
-----
K
YSSETPTIS
D
--------------
L
P
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
255
Blastp_CBE
45.54
34%
-93
- C3 -
-
5MHI
3.5
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
240
Blastp_CBE
45.50
36%
-97
- C3 -
-
2GNL
5.5
-
KAPCA_BOVIN
A:
[48-297]
--------------------
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
K
--
V
A
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
265
Blastp_CBE
45.49
34%
-100
- C3 -
-
5LCT
5.2
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
267
Blastp_CBE
45.46
34%
-95
- C3 -
-
5LCQ
5.6
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
372
Blastp_CBE
45.39
35%
-98
- C3 -
-
2C1A
6.6
-
KAPCA_BOVIN
A:
[49-298]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
266
Blastp_CBE
45.43
34%
-99
- C3 -
-
5LCR
5.3
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
123
Blastp_CBE
45.42
33%
-47
- C3 -
-
6BFA
5.4
-
?
A:
[34-347]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
----
R
--
I
I
D
F
G
L
S
----
T
H
-
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
G
A
N
E
Y
D
--
I
-
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
---
L
--
P
----
Q
--
W
KK--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
---------
Y
--------------
T
K
E
Q
I
S
V
-
D
V
P
S
L
D
N
A
I
-
L
--
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
343
Blastp_CBE
45.36
35%
-96
- C3 -
-
3DND
4.2
-
KAPCA_BOVIN
A:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
-----
F
GNLKD
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
202
Blastp_CBE
45.39
37%
-93
- C3 -
-
4BDB
3.5
-
CHK2_HUMAN
A:
[17-287]
--------------
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
---------
L
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
----
K
--
I
T
D
F
G
H
S
----
K
I
-
L
----
E
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
---
S
E
H
R
T
Q
V
--
S
-
L
K
D
Q
I
T
S
G
--
K
--
Y
N
F
---
I
--
P
----
E
--
V
WAE-
V
S
E
K
--
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
---------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134
Blastp_CBE
45.37
33%
-50
- C3 -
-
4ONA
6.3
-
?
A:
[34-347]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
----
R
--
I
I
D
F
G
L
S
----
T
H
-
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
G
A
N
E
Y
D
--
I
-
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
---
L
--
P
----
Q
--
W
KK--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
---------
Y
--------------
T
K
E
Q
I
S
V
-
D
V
P
S
L
D
N
A
I
-
L
--
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
135
Blastp_CBE
45.36
33%
-50
- C3 -
-
4M84
4.1
-
?
A:
[34-347]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
----
R
--
I
I
D
F
G
L
S
----
T
H
-
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
G
A
N
E
Y
D
--
I
-
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
---
L
--
P
----
Q
--
W
KK--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
---------
Y
--------------
T
K
E
Q
I
S
V
-
D
V
P
S
L
D
N
A
I
-
L
--
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
260
Blastp_CBE
45.35
34%
-98
- C3 -
-
5M0U
Error
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
----
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
146
Blastp_CBE
45.29
33%
-48
- C3 -
-
3N51
7.2
-
?
A:
[34-362]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
----
R
--
I
I
D
F
G
L
S
----
T
H
-
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
G
A
N
E
Y
D
--
I
-
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
---
L
--
P
----
Q
--
W
KK--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
---------
Y
--------------
T
K
E
Q
I
S
V
-
D
V
P
S
L
D
N
A
I
-
L
--
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
149
Blastp_CBE
45.25
33%
-50
- C3 -
-
4IHP
6.5
-
?
A:
[57-378]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
----
R
--
I
I
D
F
G
L
S
----
T
H
-
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
G
A
N
E
Y
D
--
I
-
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
---
L
--
P
----
Q
--
W
KK--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
---------
Y
--------------
T
K
E
Q
I
S
---
V
P
S
L
D
N
A
I
-
L
--
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
127
Blastp_CBE
45.23
33%
-47
- C3 -
-
5W8R
7.2
-
?
A:
[34-353]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
----
R
--
I
I
D
F
G
L
S
----
T
H
-
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
G
A
N
E
Y
D
--
I
-
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
---
L
--
P
----
Q
--
W
KK--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
---------
Y
--------------
T
K
E
Q
--
V
-
D
V
P
S
L
D
N
A
I
-
L
--
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
310
Blastp_CBE
45.21
35%
-96
- C3 -
-
3IDC
6.2
-
KAPCA_MOUSE
A:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
244
Blastp_CBE
45.20
34%
-101
- C3 -
-
6F14
4.6
-
KAPCA_CRIGR
A:
[39-298]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
----
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
261
Blastp_CBE
45.15
34%
-95
- C3 -
-
5M0L
4.3
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
238
Blastp_CBE
45.15
34%
-84
- C3 -
-
5XZV
3.3
-
?
B:
[199-466]
----------------
I
I
D
E
V
V
G
Q
G
A
F
A
T
V
K
K
A
I
E
R
T
T
G
K
T
F
A
V
K
I
I
S
----
K
R
K
------
M
D
G
-
V
T
R
E
L
E
V
L
Q
-
K
L
N
-
H
P
R
I
V
R
L
K
G
F
Y
E
D
T
E
S
Y
Y
M
V
M
E
F
V
S
G
G
D
L
M
D
F
V
A
A
H
G
A
V
G
E
D
A
G
R
E
I
S
R
Q
I
L
T
A
I
K
Y
I
H
S
M
G
I
S
H
R
D
L
K
P
D
N
I
L
---
I
EQ---
D
---
D
P
---
V
L
---
V
----
K
--
I
T
D
F
G
L
----------------------
T
F
C
G
T
L
A
Y
V
A
P
E
V
I
----------------RNEYSSL
V
D
M
W
S
M
G
C
L
V
Y
V
I
L
T
G
H
L
P
F
---
S
G
S
T
Q
D
Q
--
L
-
Y
K
-
Q
I
G
R
G
--
S
--
Y
-
H
EGP
L
--
K
----
D
--
F
R---
I
S
E
E
--
A
R
D
F
I
D
S
L
L
Q
V
D
P
N
N
-----
R
-----
S
-----
T
A
A
K
A
L
N
H
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
417
Blastp_CBE
45.12
35%
-96
- C3 -
-
2JDV
7.2
-
KAPCA_BOVIN
A:
[49-298]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
K
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
151
Blastp_CBE
45.06
33%
-48
- C3 -
-
4IFG
7.8
-
?
A:
[57-377]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
----
R
--
I
I
D
F
G
L
S
----
T
H
-
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
G
A
N
E
Y
D
--
I
-
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
---
L
--
P
----
Q
--
W
KK--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
---------
Y
--------------
T
K
------
D
V
P
S
L
D
N
A
I
-
L
--
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
273
Blastp_CBE
45.05
35%
-100
- C3 -
-
1YDS
4.5
-
KAPCA_BOVIN
E:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
-----
F
GNLKD
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110
Blastp_CBE
44.99
38%
-95
- C3 -
-
2JC6
5.5
-
KCC1D_HUMAN
C:
[24-283]
---------------
F
E
F
K
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
P
----
K
K
A
--------
S
-
I
E
N
E
I
A
V
L
R
-
K
I
K
-
H
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
---
Y
YSQ--
D
---
E
E
---
S
K
---
I
----
M
--
I
S
-------------------------------
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
-----
K
--
A
--------
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
---
Y
D
E
N
D
S
K
--
L
-
F
E
-
Q
I
L
K
A
--
E
--
Y
-
E
---
F
DS
P
----
Y
--
W
DD--
I
S
D
S
--
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
-----
R
-----
Y
-----
T
C
E
Q
A
A
R
H
P
W
I
A
-----
G
---------
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129
Blastp_CBE
44.96
33%
-49
- C3 -
-
4YJN
4.3
-
?
A:
[34-347]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
----
R
--
I
I
D
F
G
L
S
----
T
H
-
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
G
A
N
E
Y
D
--
I
-
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
---
L
--
P
----
Q
--
W
KK--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
---------
Y
--------------
T
K
E
------
V
P
S
L
D
N
A
I
-
L
--
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
252
Blastp_CBE
44.92
34%
-89
- C3 -
-
5N1K
3.7
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
-
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
147
Blastp_CBE
44.93
33%
-47
- C3 -
-
3I7B
7.3
-
?
A:
[34-350]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
----
R
--
I
I
D
F
G
L
S
----
T
H
-
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
G
A
N
E
Y
D
--
I
-
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
---
L
--
P
----
Q
--
W
KK--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
---------
Y
--------------
T
K
E
Q
I
S
V
-
D
V
P
S
L
D
N
A
I
-
L
--
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
404
Blastp_CBE
44.87
35%
-96
- C3 -
-
4Z84
6.2
-
KAPCA_BOVIN
A:
[49-298]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
K
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
122
Blastp_CBE
44.92
33%
-50
- C3 -
-
3HX4
4.8
-
?
A:
[58-371]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
-------
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
----
R
--
I
I
D
F
G
L
S
----
T
H
-
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
G
A
N
E
Y
D
--
I
-
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
---
L
--
P
----
Q
--
W
KK--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
---------
Y
--------------
T
K
E
Q
I
S
V
-
D
V
P
S
L
D
N
A
I
-
L
--
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
375
Blastp_CBE
44.90
35%
-93
- C3 -
-
3L9M
6.6
-
KAPCA_HUMAN
A:
[49-298]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
K
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
130
Blastp_CBE
44.89
33%
-48
- C3 -
-
4WG5
8.3
-
?
A:
[34-347]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
----
R
--
I
I
D
F
G
L
S
----
T
H
-
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
G
A
N
E
Y
D
--
I
-
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
---
L
--
P
----
Q
--
W
KK--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
---------
Y
--------------
T
K
E
Q
I
S
V
-
D
V
P
S
L
D
N
A
I
-
L
--
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
138
Blastp_CBE
44.87
33%
-46
- C3 -
-
3V5P
6.2
-
?
A:
[34-356]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
----
R
--
I
I
D
F
G
L
S
----
T
H
-
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
G
A
N
E
Y
D
--
I
-
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
---
L
--
P
----
Q
--
W
KK--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
---------
Y
--------------
T
K
-------
V
P
S
L
D
N
A
I
-
L
--
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
416
Blastp_CBE
44.86
35%
-94
- C3 -
-
2UVX
4.0
-
KAPCA_BOVIN
A:
[49-298]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
K
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
313
Blastp_CBE
44.83
35%
-96
- C3 -
-
1REK
10.6
-
KAPCA_MOUSE
A:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
121
Blastp_CBE
44.81
37%
-68
- C3 -
-
3MA6
4.1
-
?
A:
[39-292]
--------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
----
R
--
I
I
D
F
G
L
S
----
T
H
-
F
---
E
-
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
G
A
N
E
Y
D
--
I
-
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
---
L
--
P
----
Q
--
W
KK--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
301
Blastp_CBE
44.80
35%
-90
- C3 -
-
6MM7
3.0
-
KAPCA_MOUSE
D:
[37-298]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
194
Blastp_CBE
44.78
37%
-91
- C3 -
-
4BDJ
5.3
-
CHK2_HUMAN
A:
[17-287]
--------------
E
Y
I
M
S
K
T
L
-----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
----------
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
----
K
--
I
T
D
F
G
H
S
----
K
I
-
L
----
E
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
---
S
E
H
R
T
Q
V
--
S
-
L
K
D
Q
I
T
S
G
--
K
--
Y
N
F
---
I
--
P
----
E
--
V
WAE-
V
S
E
K
--
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
---------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
317
Blastp_CBE
44.74
35%
-96
- C3 -
-
1FMO
5.1
-
KAPCA_MOUSE
E:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
365
Blastp_CBE
44.73
35%
-92
- C3 -
-
6E9L
7.4
-
KAPCA_BOVIN
A:
[49-298]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
485
Blastp_CBE
44.66
34%
-93
- C3 -
-
1RDQ
7.7
-
KAPCA_MOUSE
E:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
A
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
275
Blastp_CBE
44.72
35%
-94
- C3 -
-
5UZK
9.2
-
KAPCA_HUMAN
A:
[49-298]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
340
Blastp_CBE
44.65
35%
-98
- C3 -
-
4YXS
5.2
-
KAPCA_BOVIN
A:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
-----
F
GNLKD
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
342
Blastp_CBE
44.64
35%
-95
- C3 -
-
3DNE
4.9
-
KAPCA_BOVIN
A:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
-----
F
GNLKD
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
371
Blastp_CBE
44.63
35%
-96
- C3 -
-
2C1B
6.6
-
KAPCA_BOVIN
A:
[49-298]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
328
Blastp_CBE
44.63
35%
-92
- C3 -
-
1JBP
6.1
-
KAPCA_MOUSE
E:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
E
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
283
Blastp_CBE
44.66
35%
-96
- C3 -
-
4UJ1
5.9
-
KAPCA_HUMAN
A:
[49-298]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
290
Blastp_CBE
44.65
35%
-96
- C3 -
-
3L9L
7.8
-
KAPCA_HUMAN
B:
[49-298]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
145
Blastp_CBE
44.64
33%
-49
- C3 -
-
3SX9
5.6
-
?
A:
[34-351]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
----
R
--
I
I
D
F
G
L
S
----
T
H
-
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
G
A
N
E
Y
D
--
I
-
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
---
L
--
P
----
Q
--
W
KK--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
---------
Y
--------------
T
K
------
D
V
P
S
L
D
N
A
I
-
L
--
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
246
Blastp_CBE
44.63
35%
-96
- C3 -
-
1CDK
8.5
-
KAPCA_PIG
A:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
F
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
Y
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
-----
F
GNLKD
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
379
Blastp_CBE
44.61
35%
-66
- C3 -
-
4YZB
5.7
-
?
A:
[38-310]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
V
T
G
Q
E
Y
A
V
K
V
I
S
----
K
R
---
Q
K
T
D
K
E
L
-
L
L
K
E
V
E
L
L
K
-
K
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
NKR
K
D
---
A
N
---
I
----
R
--
I
I
D
F
G
L
S
----
T
H
-
F
---
E
S
T
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
G
A
N
E
F
D
--
I
-
L
K
-
K
V
E
K
G
KF
T
--
F
-
D
---
L
--
P
----
Q
--
W
KK--
V
S
E
P
--
A
K
D
L
I
R
K
M
L
A
Y
V
P
T
M
-----
R
-----
I
-----
S
A
R
D
A
L
E
H
E
W
L
K
-----
T
---------------------------
T
D
S
I
-
D
V
P
S
L
E
S
T
I
-
L
--
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
128
Blastp_CBE
44.60
33%
-50
- C3 -
-
5W80
6.9
-
?
A:
[34-354]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
----
R
--
I
I
D
F
G
L
S
----
T
H
-
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
G
A
N
E
Y
D
--
I
-
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
---
L
--
P
----
Q
--
W
KK--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
---------
Y
--------------
T
K
----
V
-
D
V
P
S
L
D
N
A
I
-
L
--
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
322
Blastp_CBE
44.56
35%
-93
- C3 -
-
1BX6
6.7
-
KAPCA_MOUSE
A:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
132
Blastp_CBE
44.56
33%
-52
- C3 -
-
4WG3
7.5
-
?
A:
[34-347]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
----
R
--
I
I
D
F
G
L
S
----
T
H
-
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
G
A
N
E
Y
D
--
I
-
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
---
L
--
P
----
Q
--
W
KK--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
---------
Y
--------------
T
K
------
D
V
P
S
L
D
N
A
I
-
L
--
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
167
Blastp_CBE
44.54
37%
-62
- C3 -
-
2WEI
6.7
-
?
A:
[30-282]
---------------------
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
----
K
A
S
A
K
N
K
D
T
-
S
T
-
I
L
R
E
V
E
L
L
K
-
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
-----
E
---
S
K
EKD
C
D
---
I
----
K
--
I
I
D
F
G
L
S
----
T
C
-
F
---
Q
Q
N
---
T
K
M
K
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
---
Y
G
K
N
E
Y
D
--
I
-
L
K
-
R
V
E
T
G
KY
A
--
F
-
D
---
L
--
P
----
Q
--
W
RT--
I
S
D
D
--
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
-----
R
-----
I
-----
T
A
T
Q
C
L
E
H
P
W
I
Q
-----
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
154
Blastp_CBE
44.54
33%
-64
- C3 -
-
5T6I
6.5
-
?
A:
[75-505]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
--
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SK-
A
N
---
I
----
R
--
I
I
D
F
G
L
S
----
T
H
-
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
G
A
N
E
Y
D
--
I
-
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
---
L
--
P
----
Q
--
W
KK--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
---------
Y
--------------
T
--------
V
P
S
L
D
N
A
I
-
L
--
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
-
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
396
Blastp_CBE
44.53
35%
-88
- C3 -
-
2GNI
5.3
-
KAPCA_BOVIN
A:
[48-297]
--------------------
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
K
--
V
A
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
378
Blastp_CBE
44.46
35%
-66
- C3 -
-
4YZB
6.1
-
?
B:
[38-310]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
V
T
G
Q
E
Y
A
V
K
V
I
S
----
K
R
---
Q
K
T
D
K
E
L
-
L
L
K
E
V
E
L
L
K
-
K
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
NKR
K
D
---
A
N
---
I
----
R
--
I
I
D
F
G
L
S
----
T
H
-
F
---
E
S
T
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
G
A
N
E
F
D
--
I
-
L
K
-
K
V
E
K
G
KF
T
--
F
-
D
---
L
--
P
----
Q
--
W
KK--
V
S
E
P
--
A
K
D
L
I
R
K
M
L
A
Y
V
P
T
M
-----
R
-----
I
-----
S
A
R
D
A
L
E
H
E
W
L
K
-----
T
-----------------------------
S
I
-
D
V
P
S
L
E
S
T
I
-
L
--
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
339
Blastp_CBE
44.50
35%
-93
- C3 -
-
1SVH
8.5
-
KAPCA_BOVIN
A:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
120
Blastp_CBE
44.48
37%
-62
- C3 -
-
3MA6
5.6
-
?
B:
[39-292]
--------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
-
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
----
R
--
I
I
D
F
G
L
S
----
T
H
-
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
G
A
N
E
Y
D
--
I
-
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
---
L
--
P
----
Q
--
W
KK--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
288
Blastp_CBE
44.45
35%
-91
- C3 -
-
3OVV
6.5
-
KAPCA_HUMAN
A:
[49-298]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
360
Blastp_CBE
44.47
35%
-93
- C3 -
-
1Q8U
6.1
-
KAPCA_BOVIN
A:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
136
Blastp_CBE
44.46
33%
-49
- C3 -
-
4JBV
6.6
-
?
A:
[34-347]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
----
R
--
I
I
D
F
G
L
S
----
T
H
-
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
G
A
N
E
Y
D
--
I
-
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
---
L
--
P
----
Q
--
W
KK--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
---------
Y
--------------
T
K
------
D
V
P
S
L
D
N
A
I
-
L
--
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
124
Blastp_CBE
44.45
33%
-49
- C3 -
-
5W9R
7.1
-
?
A:
[34-361]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
----
R
--
I
I
D
F
G
L
S
----
T
H
-
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
G
A
N
E
Y
D
--
I
-
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
---
L
--
P
----
Q
--
W
KK--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
---------
Y
--------------
T
K
------
D
V
P
S
L
D
N
A
I
-
L
--
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
319
Blastp_CBE
44.40
35%
-93
- C3 -
-
6C0U
7.8
-
KAPCA_HUMAN
A:
[52-301]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
190
Blastp_CBE
44.42
37%
-87
- C3 -
-
2YCQ
7.7
-
CHK2_HUMAN
A:
[11-281]
--------------
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
----------
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
----
K
--
I
T
D
F
G
H
S
----
K
I
-
L
---
G
E
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
---
S
E
H
R
T
Q
V
--
S
-
L
K
D
Q
I
T
S
G
--
K
--
Y
N
F
---
I
--
P
----
E
--
V
WAE-
V
S
E
K
--
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
---------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
303
Blastp_CBE
44.39
35%
-96
- C3 -
-
6MM6
3.1
-
KAPCA_MOUSE
E:
[37-299]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
216
Blastp_CBE
44.39
37%
-87
- C3 -
-
2CN5
6.4
-
CHK2_HUMAN
A:
[17-287]
--------------
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
R
---------
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
----
K
--
I
T
D
F
G
H
S
----
K
I
-
L
---
G
E
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
---
S
E
H
R
T
Q
V
--
S
-
L
K
D
Q
I
T
S
G
--
K
--
Y
N
F
---
I
--
P
----
E
--
V
WAE-
V
S
E
K
--
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
---------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
315
Blastp_CBE
44.37
35%
-90
- C3 -
-
1RE8
8.2
-
KAPCA_MOUSE
A:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
186
Blastp_CBE
44.39
37%
-88
- C3 -
-
2YIT
7.3
-
CHK2_HUMAN
A:
[11-281]
--------------
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
---------
L
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
----
K
--
I
T
D
F
G
H
S
----
K
I
-
L
---
G
E
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
---
S
E
H
R
T
Q
V
--
S
-
L
K
D
Q
I
T
S
G
--
K
--
Y
N
F
---
I
--
P
----
E
--
V
WAE-
V
S
E
K
--
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
---------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
326
Blastp_CBE
44.35
35%
-102
- C3 -
-
4NTT
4.8
-
KAPCA_MOUSE
A:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
395
Blastp_CBE
44.38
35%
-90
- C3 -
-
2GNF
4.9
-
KAPCA_BOVIN
A:
[48-297]
--------------------
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
K
--
V
A
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
293
Blastp_CBE
44.37
35%
-92
- C3 -
-
5BX7
4.3
-
KAPCA_HUMAN
A:
[49-298]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
418
Blastp_CBE
44.36
35%
-90
- C3 -
-
2JDT
6.3
-
KAPCA_BOVIN
A:
[49-298]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
K
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
139
Blastp_CBE
44.35
33%
-48
- C3 -
-
3V51
6.3
-
?
A:
[34-348]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
----
R
--
I
I
D
F
G
L
S
----
T
H
-
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
G
A
N
E
Y
D
--
I
-
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
---
L
--
P
----
Q
--
W
KK--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
---------
Y
--------------
T
K
------
D
V
P
S
L
D
N
A
I
-
L
--
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
401
Blastp_CBE
44.29
34%
-92
- C3 -
-
3QAL
8.1
-
KAPCA_MOUSE
E:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
AFGNL
K
-----
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
189
Blastp_CBE
44.34
37%
-93
- C3 -
-
2YCS
6.6
-
CHK2_HUMAN
A:
[11-281]
--------------
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
----------
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
----
K
--
I
T
D
F
G
H
S
----
K
I
-
L
-----
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
---
S
E
H
R
T
Q
V
--
S
-
L
K
D
Q
I
T
S
G
--
K
--
Y
N
F
---
I
--
P
----
E
--
V
WAE-
V
S
E
K
--
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
---------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
368
Blastp_CBE
44.28
35%
-95
- C3 -
-
3ZO4
7.6
-
KAPCA_BOVIN
A:
[49-298]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
330
Blastp_CBE
44.29
35%
-93
- C3 -
-
1XH9
8.9
-
KAPCA_BOVIN
A:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
E
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
K
--
V
T
D
F
G
L
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
314
Blastp_CBE
44.32
35%
-94
- C3 -
-
1REJ
6.4
-
KAPCA_MOUSE
A:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
125
Blastp_CBE
44.31
33%
-49
- C3 -
-
5W9E
6.9
-
?
A:
[34-355]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
----
R
--
I
I
D
F
G
L
S
----
T
H
-
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
G
A
N
E
Y
D
--
I
-
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
---
L
--
P
----
Q
--
W
KK--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
---------
Y
--------------
T
K
------
D
V
P
S
L
D
N
A
I
-
L
--
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
402
Blastp_CBE
44.25
35%
-93
- C3 -
-
4Z83
6.9
-
KAPCA_BOVIN
E:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
K
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
373
Blastp_CBE
44.25
35%
-96
- C3 -
-
3L9N
6.3
-
KAPCA_HUMAN
A:
[49-301]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
K
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
280
Blastp_CBE
44.30
35%
-92
- C3 -
-
4UJA
7.1
-
KAPCA_HUMAN
A:
[49-298]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
274
Blastp_CBE
44.29
35%
-97
- C3 -
-
1YDR
5.1
-
KAPCA_BOVIN
E:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
-----
F
GNLKD
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
263
Blastp_CBE
44.28
34%
-95
- C3 -
-
5M0B
4.9
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
336
Blastp_CBE
44.27
35%
-91
- C3 -
-
1XH8
10.9
-
KAPCA_BOVIN
A:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
306
Blastp_CBE
44.25
35%
-93
- C3 -
-
4HPT
6.2
-
KAPCA_MOUSE
E:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
206
Blastp_CBE
44.23
37%
-93
- C3 -
-
4A9S
5.0
-
CHK2_HUMAN
A:
[17-287]
--------------
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
-------
P
A
L
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
----
K
--
I
T
D
F
G
H
S
----
K
I
-
L
-----
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
---
S
E
H
R
T
Q
V
--
S
-
L
K
D
Q
I
T
S
G
--
K
--
Y
N
F
---
I
--
P
----
E
--
V
WAE-
V
S
E
K
--
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
---------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
272
Blastp_CBE
44.21
35%
-97
- C3 -
-
1YDT
6.8
-
KAPCA_BOVIN
E:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
-----
F
GNLKD
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
245
Blastp_CBE
44.20
35%
-93
- C3 -
-
1CDK
8.4
-
KAPCA_PIG
B:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
F
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
Y
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
-----
F
GNLKD
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
370
Blastp_CBE
44.15
35%
-97
- C3 -
-
2VO7
8.1
-
KAPCA_BOVIN
A:
[49-298]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
381
Blastp_CBE
44.19
35%
-58
- C3 -
-
4YUQ
5.8
-
?
A:
[38-310]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
V
T
G
Q
E
Y
A
V
K
V
I
S
----
K
R
Q
--------
L
-
L
L
K
E
V
E
L
L
K
-
K
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
NKR
K
D
---
A
N
---
I
----
R
--
I
I
D
F
G
L
S
----
T
H
-
F
---
E
S
T
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
G
A
N
E
F
D
--
I
-
L
K
-
K
V
E
K
G
KF
T
--
F
-
D
---
L
--
P
----
Q
--
W
KK--
V
S
E
P
--
A
K
D
L
I
R
K
M
L
A
Y
V
P
T
M
-----
R
-----
I
-----
S
A
R
D
A
L
E
H
E
W
L
K
-----
T
---------
T
--------------
D
---
D
S
I
-
D
V
P
S
L
E
S
T
I
-
L
--
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
358
Blastp_CBE
44.12
35%
-93
- C3 -
-
1SVE
7.9
-
KAPCA_BOVIN
A:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
131
Blastp_CBE
44.15
33%
-47
- C3 -
-
4WG4
7.4
-
?
A:
[34-353]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
----
R
--
I
I
D
F
G
L
S
----
T
H
-
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
G
A
N
E
Y
D
--
I
-
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
---
L
--
P
----
Q
--
W
KK--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
---------
Y
--------------
T
K
------
D
V
P
S
L
D
N
A
I
-
L
--
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
338
Blastp_CBE
44.10
35%
-93
- C3 -
-
1XH5
9.3
-
KAPCA_BOVIN
A:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
337
Blastp_CBE
44.13
35%
-94
- C3 -
-
1XH6
9.6
-
KAPCA_BOVIN
A:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
200
Blastp_CBE
44.12
37%
-99
- C3 -
-
4BDD
4.8
-
CHK2_HUMAN
A:
[17-287]
--------------
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
----------
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
----
K
--
I
T
D
F
G
H
S
----
K
I
-
L
-----
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
---
S
E
H
R
T
Q
V
--
S
-
L
K
D
Q
I
T
S
G
--
K
--
Y
N
F
---
I
--
P
----
E
--
V
WAE-
V
S
E
K
--
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
---------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
192
Blastp_CBE
44.12
37%
-93
- C3 -
-
2W0J
6.0
-
CHK2_HUMAN
A:
[11-282]
--------------
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
----------
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
----
K
--
I
T
D
F
G
H
S
----
K
I
-
L
-----
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
---
S
E
H
R
T
Q
V
--
S
-
L
K
D
Q
I
T
S
G
--
K
--
Y
N
F
---
I
--
P
----
E
--
V
WAE-
V
S
E
K
--
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
---------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
323
Blastp_CBE
44.07
35%
-99
- C3 -
-
1BKX
5.1
-
KAPCA_MOUSE
A:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
300
Blastp_CBE
44.10
35%
-95
- C3 -
-
6MM8
3.1
-
KAPCA_MOUSE
C:
[37-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
361
Blastp_CBE
44.05
35%
-91
- C3 -
-
1Q8T
4.7
-
KAPCA_BOVIN
A:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
241
Blastp_CBE
44.07
36%
-90
- C3 -
-
2GNJ
5.4
-
KAPCA_BOVIN
A:
[48-297]
--------------------
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
K
--
V
A
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
199
Blastp_CBE
44.06
37%
-97
- C3 -
-
4BDE
4.3
-
CHK2_HUMAN
A:
[17-287]
--------------
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
--------
A
L
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
----
K
--
I
T
D
F
G
H
S
----
K
I
-
L
-----
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
---
S
E
H
R
T
Q
V
--
S
-
L
K
D
Q
I
T
S
G
--
K
--
Y
N
F
---
I
--
P
----
E
--
V
WAE-
V
S
E
K
--
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
---------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
412
Blastp_CBE
43.99
35%
-89
- C3 -
-
2VO0
7.0
-
KAPCA_BOVIN
A:
[49-298]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
K
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
193
Blastp_CBE
44.05
37%
-87
- C3 -
-
4BDK
3.7
-
CHK2_HUMAN
A:
[17-287]
--------------
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
--------
A
L
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
----
K
--
I
T
D
F
G
H
S
----
K
I
-
L
---
G
E
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
---
S
E
H
R
T
Q
V
--
S
-
L
K
D
Q
I
T
S
G
--
K
--
Y
N
F
---
I
--
P
----
E
--
V
WAE-
V
S
E
K
--
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
---------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
311
Blastp_CBE
44.02
35%
-92
- C3 -
-
3IDB
6.1
-
KAPCA_MOUSE
A:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
284
Blastp_CBE
44.02
35%
-92
- C3 -
-
3POO
7.0
-
KAPCA_HUMAN
A:
[49-302]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
374
Blastp_CBE
44.04
35%
-93
- C3 -
-
3L9M
6.8
-
KAPCA_HUMAN
B:
[49-298]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
K
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
184
Blastp_CBE
44.02
37%
-90
- C3 -
-
2YCR
6.5
-
CHK2_HUMAN
A:
[11-281]
--------------
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
----------
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
----
K
--
I
T
D
F
G
H
S
----
K
I
-
L
---
G
E
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
---
S
E
H
R
T
Q
V
--
S
-
L
K
D
Q
I
T
S
G
--
K
--
Y
N
F
---
I
--
P
----
E
--
V
WAE-
V
S
E
K
--
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
---------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
312
Blastp_CBE
44.01
35%
-92
- C3 -
-
3FJQ
9.0
-
KAPCA_MOUSE
E:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
295
Blastp_CBE
43.99
35%
-91
- C3 -
-
4UJB
6.7
-
KAPCA_HUMAN
A:
[49-298]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
357
Blastp_CBE
43.94
35%
-93
- C3 -
-
1SVG
8.6
-
KAPCA_BOVIN
A:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
289
Blastp_CBE
43.98
35%
-93
- C3 -
-
3OOG
4.3
-
KAPCA_HUMAN
A:
[49-298]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
385
Blastp_CBE
43.97
35%
-60
- C3 -
-
4YSJ
6.1
-
?
A:
[38-310]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
V
T
G
Q
E
Y
A
V
K
V
I
S
----
K
R
-----------
L
L
K
E
V
E
L
L
K
-
K
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
NKR
K
D
---
A
N
---
I
----
R
--
I
I
D
F
G
L
S
----
T
H
-
F
---
E
S
T
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
G
A
N
E
F
D
--
I
-
L
K
-
K
V
E
K
G
KF
T
--
F
-
D
---
L
--
P
----
Q
--
W
KK--
V
S
E
P
--
A
K
D
L
I
R
K
M
L
A
Y
V
P
T
M
-----
R
-----
I
-----
S
A
R
D
A
L
E
H
E
W
L
K
-----
T
---------
T
-------------------
S
I
-
D
V
P
S
L
E
S
T
I
-
L
--
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
137
Blastp_CBE
43.96
33%
-48
- C3 -
-
3V5T
6.8
-
?
A:
[34-347]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
----
R
--
I
I
D
F
G
L
S
----
T
H
-
F
---
E
A
S
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
G
A
N
E
Y
D
--
I
-
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
---
L
--
P
----
Q
--
W
KK--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
---------
Y
--------------
T
K
------
D
V
P
S
L
D
N
A
I
-
L
--
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
116
Blastp_CBE
43.96
39%
-79
- C3 -
-
4FG8
4.2
-
KCC1A_HUMAN
B:
[20-279]
---------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
----
K
--------------
N
E
I
A
V
L
H
-
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
-----
D
---
E
D
---
S
K
---
I
----
M
--
I
S
D
F
G
---------------
G
---
S
V
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
-----
K
--
A
--------
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
---
Y
D
E
N
D
A
K
--
L
-
F
E
-
Q
I
L
K
A
--
E
--
Y
-
E
---
F
DS
P
----
Y
--
W
DD--
I
S
D
S
--
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
-----
R
-----
F
-----
T
C
E
Q
A
L
Q
H
P
W
I
A
-----
G
---------
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
366
Blastp_CBE
43.91
35%
-92
- C3 -
-
6E99
7.5
-
KAPCA_BOVIN
A:
[49-298]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
307
Blastp_CBE
43.95
35%
-92
- C3 -
-
4DIN
7.4
-
KAPCA_MOUSE
A:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
198
Blastp_CBE
43.94
37%
-84
- C3 -
-
4BDF
4.8
-
CHK2_HUMAN
A:
[17-287]
--------------
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
----------
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
----
K
--
I
T
D
F
G
H
S
----
K
I
-
L
---
G
E
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
---
S
E
H
R
T
Q
V
--
S
-
L
K
D
Q
I
T
S
G
--
K
--
Y
N
F
---
I
--
P
----
E
--
V
WAE-
V
S
E
K
--
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
---------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
407
Blastp_CBE
43.86
35%
-87
- C3 -
-
3AMB
7.0
-
KAPCA_HUMAN
A:
[49-303]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
Q
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
K
--
V
A
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
286
Blastp_CBE
43.91
35%
-94
- C3 -
-
3OXT
5.8
-
KAPCA_HUMAN
A:
[49-298]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
408
Blastp_CBE
43.90
35%
-93
- C3 -
-
3AMA
6.5
-
KAPCA_HUMAN
A:
[49-303]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
Q
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
K
--
V
A
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
197
Blastp_CBE
43.88
37%
-86
- C3 -
-
4BDG
3.9
-
CHK2_HUMAN
A:
[17-287]
--------------
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
----------
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
----
K
--
I
T
D
F
G
H
S
----
K
I
-
L
---
G
E
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
---
S
E
H
R
T
Q
V
--
S
-
L
K
D
Q
I
T
S
G
--
K
--
Y
N
F
---
I
--
P
----
E
--
V
WAE-
V
S
E
K
--
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
---------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
341
Blastp_CBE
43.87
35%
-93
- C3 -
-
4YXR
4.1
-
KAPCA_BOVIN
A:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
-----
F
GNLKD
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
324
Blastp_CBE
43.86
35%
-94
- C3 -
-
2GU8
7.1
-
KAPCA_HUMAN
A:
[35-284]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
E
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
367
Blastp_CBE
43.81
35%
-92
- C3 -
-
4IE9
4.9
-
KAPCA_BOVIN
A:
[49-298]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
213
Blastp_CBE
43.85
37%
-88
- C3 -
-
2WTD
6.2
-
CHK2_HUMAN
A:
[17-287]
--------------
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
-------
P
A
L
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
----
K
--
I
T
D
F
G
H
S
----
K
I
-
L
-----
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
---
S
E
H
R
T
Q
V
--
S
-
L
K
D
Q
I
T
S
G
--
K
--
Y
N
F
---
I
--
P
----
E
--
V
WAE-
V
S
E
K
--
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
---------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
113
Blastp_CBE
43.84
38%
-86
- C3 -
-
6T6F
5.5
-
?
A:
[16-290]
---------------
F
E
F
K
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
P
----
K
K
A
L
K
G
K
E
--
S
S
-
I
E
N
E
I
A
V
L
R
-
K
I
K
-
H
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
---
Y
YSQ--
D
---
E
E
---
S
K
---
I
----
M
--
I
S
D
F
G
L
S
--------------------------
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
-----
K
--
A
--------
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
---
Y
D
E
N
D
S
K
--
L
-
F
E
-
Q
I
L
K
A
--
E
--
Y
-
E
---
F
DS
P
----
Y
--
W
DD--
I
S
D
S
--
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
-----
R
-----
Y
-----
T
C
E
Q
A
A
R
H
P
W
I
A
-----
G
---------
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
413
Blastp_CBE
43.83
35%
-90
- C3 -
-
4AXA
6.8
-
KAPCA_BOVIN
A:
[49-298]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
K
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
397
Blastp_CBE
43.77
35%
-93
- C3 -
-
2GNH
5.9
-
KAPCA_BOVIN
A:
[48-297]
--------------------
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
K
--
V
A
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
112
Blastp_CBE
43.81
38%
-91
- C3 -
-
6T6F
5.7
-
?
B:
[16-290]
---------------
F
E
F
K
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
P
----
K
K
A
L
K
G
K
E
--
S
S
-
I
E
N
E
I
A
V
L
R
-
K
I
K
-
H
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
---
Y
YSQ--
D
---
E
E
---
S
K
---
I
----
M
--
I
S
D
F
G
----------------------------
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
-----
K
--
A
--------
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
---
Y
D
E
N
D
S
K
--
L
-
F
E
-
Q
I
L
K
A
--
E
--
Y
-
E
---
F
DS
P
----
Y
--
W
DD--
I
S
D
S
--
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
-----
R
-----
Y
-----
T
C
E
Q
A
A
R
H
P
W
I
A
-----
G
---------
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
294
Blastp_CBE
43.80
35%
-90
- C3 -
-
5BX6
4.4
-
KAPCA_HUMAN
A:
[49-298]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
119
Blastp_CBE
43.78
39%
-87
- C3 -
-
4FG9
5.9
-
KCC1A_HUMAN
A:
[20-279]
---------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
----
K
E
------------
E
N
E
I
A
V
L
H
-
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
-----
D
---
E
D
---
S
K
---
I
----
M
--
I
S
D
F
-----------------------------
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
-----
K
--
A
--------
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
---
Y
D
E
N
D
A
K
--
L
-
F
E
-
Q
I
L
K
A
--
E
--
Y
-
E
---
F
DS
P
----
Y
--
W
DD--
I
S
D
S
--
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
-----
R
-----
F
-----
T
C
E
Q
A
L
Q
H
P
W
I
A
-----
G
---------
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
285
Blastp_CBE
43.77
35%
-92
- C3 -
-
3P0M
6.3
-
KAPCA_HUMAN
A:
[49-298]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
296
Blastp_CBE
43.74
35%
-91
- C3 -
-
3VQH
7.0
-
KAPCA_HUMAN
A:
[49-298]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
334
Blastp_CBE
43.72
35%
-94
- C3 -
-
4IJ9
6.8
-
KAPCA_BOVIN
A:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
380
Blastp_CBE
43.64
35%
-57
- C3 -
-
4YUQ
5.8
-
?
B:
[38-310]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
V
T
G
Q
E
Y
A
V
K
V
I
S
----
K
R
Q
----------
L
L
K
E
V
E
L
L
K
-
K
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
NKR
K
D
---
A
N
---
I
----
R
--
I
I
D
F
G
L
S
----
T
H
-
F
---
E
S
T
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
G
A
N
E
F
D
--
I
-
L
K
-
K
V
E
K
G
KF
T
--
F
-
D
---
L
--
P
----
Q
--
W
KK--
V
S
E
P
--
A
K
D
L
I
R
K
M
L
A
Y
V
P
T
M
-----
R
-----
I
-----
S
A
R
D
A
L
E
H
E
W
L
K
-----
T
---------
T
--------------
D
---
D
S
I
-
D
V
P
S
L
E
S
T
I
-
L
--
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
185
Blastp_CBE
43.67
37%
-82
- C3 -
-
2YCF
6.9
-
CHK2_HUMAN
A:
[11-281]
--------------
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
----------
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
----
K
--
I
T
D
F
G
H
S
----
K
I
-
L
---
G
E
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
---
S
E
H
R
T
Q
V
--
S
-
L
K
D
Q
I
T
S
G
--
K
--
Y
N
F
---
I
--
P
----
E
--
V
WAE-
V
S
E
K
--
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
---------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
214
Blastp_CBE
43.66
37%
-86
- C3 -
-
2WTC
5.9
-
CHK2_HUMAN
A:
[17-287]
--------------
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
-------
P
A
L
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
----
K
--
I
T
D
F
G
H
S
----
K
I
-
L
-----
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
---
S
E
H
R
T
Q
V
--
S
-
L
K
D
Q
I
T
S
G
--
K
--
Y
N
F
---
I
--
P
----
E
--
V
WAE-
V
S
E
K
--
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
---------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
208
Blastp_CBE
43.64
37%
-85
- C3 -
-
2XM9
7.8
-
CHK2_HUMAN
A:
[17-287]
--------------
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
-------
P
A
L
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
----
K
--
I
T
D
F
G
H
S
----
K
I
-
L
---
G
E
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
---
S
E
H
R
T
Q
V
--
S
-
L
K
D
Q
I
T
S
G
--
K
--
Y
N
F
---
I
--
P
----
E
--
V
WAE-
V
S
E
K
--
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
---------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
271
Blastp_CBE
43.61
37%
-73
- C3 -
-
3HZT
5.7
-
?
A:
[12-295]
---------------------
L
G
S
G
A
Y
G
E
V
L
L
C
K
D
K
L
T
G
A
E
R
A
I
K
I
I
K
----
K
S
S
V
T
T
T
S
N
S
G
A
-
L
L
D
E
V
A
V
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
R
N
Y
Y
L
V
M
E
V
Y
R
G
G
E
L
F
D
E
I
I
L
R
Q
K
F
S
E
V
D
A
A
V
I
M
K
Q
V
L
S
G
T
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
---
S
R
DAL
I
----
K
--
I
V
D
F
G
L
S
----
A
H
-
F
---
E
V
-----------
G
T
A
Y
Y
I
A
P
E
V
L
--
R
K
K
Y
-----
D
--
E
K
-------
C
D
V
W
S
C
G
V
I
L
Y
I
L
L
C
G
Y
P
P
F
---
G
G
Q
T
D
Q
E
--
I
-
L
K
-
R
V
E
K
G
--
K
--
F
-
S
---
F
DP
P
----
D
--
W
----
T
Q
V
S
DE
A
K
Q
L
V
K
L
M
L
T
Y
E
P
S
K
-----
R
-----
I
-----
S
A
E
E
A
L
N
H
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
550
Blastp_CBE
43.63
37%
-83
- C3 -
-
3TXO
6.1
-
A:
[23-266]
-------------
D
N
F
E
F
I
R
V
L
G
K
G
S
F
G
K
V
M
L
A
R
V
K
E
T
G
D
L
Y
A
V
K
V
L
K
----
K
D
V
I
L
Q
D
D
D
V
E
C
-
T
M
T
E
K
R
I
L
S
-
L
A
R
N
H
P
F
L
T
Q
L
F
C
C
F
Q
T
P
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
S
R
R
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
K
G
I
I
Y
R
D
L
K
L
D
N
V
L
---
L
-----
D
---
H
E
---
G
H
---
C
----
K
--
L
A
D
F
G
M
C
----
K
E
G
I
---------------
C
G
T
P
D
Y
I
A
P
E
I
L
Q
E
M
L
Y
------
G
--
P
A
-------
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
A
P
F
---
E
A
E
N
E
D
D
--
L
-
F
E
-
A
I
L
N
D
--
E
--
V
-
V
---
Y
--
P
----
T
--
W
----
L
H
E
D
--
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
-----
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
299
Blastp_CBE
43.59
35%
-87
- C3 -
-
4WB6
8.8
-
KAPCA_HUMAN
B:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
R
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
292
Blastp_CBE
43.59
35%
-90
- C3 -
-
3AGM
7.0
-
KAPCA_HUMAN
A:
[49-298]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
201
Blastp_CBE
43.61
37%
-91
- C3 -
-
4BDC
3.3
-
CHK2_HUMAN
A:
[17-287]
--------------
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
----------
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
----
K
--
I
T
D
F
G
H
S
----
K
I
-
L
----
E
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
---
S
E
H
R
T
Q
V
--
S
-
L
K
D
Q
I
T
S
G
--
K
--
Y
N
F
---
I
--
P
----
E
--
V
WAE-
V
S
E
K
--
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
---------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
183
Blastp_CBE
43.60
37%
-82
- C3 -
-
2XK9
6.7
-
CHK2_HUMAN
A:
[10-280]
--------------
E
Y
I
M
S
K
T
L
G
S
G
A
-
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
----------
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
----
K
--
I
T
D
F
G
H
S
----
K
I
-
L
---
G
E
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
---
S
E
H
R
T
Q
V
--
S
-
L
K
D
Q
I
T
S
G
--
K
--
Y
N
F
---
I
--
P
----
E
--
V
WAE-
V
S
E
K
--
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
---------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
211
Blastp_CBE
43.59
37%
-85
- C3 -
-
2WTJ
3.6
-
CHK2_HUMAN
A:
[17-287]
--------------
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
-------
P
A
L
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
----
K
--
I
T
D
F
G
H
S
----
K
I
-
L
----
E
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
---
S
E
H
R
T
Q
V
--
S
-
L
K
D
Q
I
T
S
G
--
K
--
Y
N
F
---
I
--
P
----
E
--
V
WAE-
V
S
E
K
--
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
---------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
415
Blastp_CBE
43.58
35%
-86
- C3 -
-
2UW4
3.6
-
KAPCA_BOVIN
A:
[49-298]
--------------------
T
L
G
T
G
S
-
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
K
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
421
Blastp_CBE
43.50
34%
-93
- C3 -
-
1Q24
7.6
-
KAPCA_BOVIN
A:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
282
Blastp_CBE
43.56
35%
-92
- C3 -
-
4UJ2
6.5
-
KAPCA_HUMAN
A:
[49-298]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
410
Blastp_CBE
43.49
35%
-93
- C3 -
-
1SMH
3.1
-
KAPCA_BOVIN
A:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
E
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
L
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
191
Blastp_CBE
43.51
37%
-83
- C3 -
-
2W7X
7.3
-
CHK2_HUMAN
A:
[11-281]
--------------
E
Y
I
M
S
K
T
L
G
S
G
A
-
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
----------
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
----
K
--
I
T
D
F
G
H
S
----
K
I
-
L
---
G
E
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
---
S
E
H
R
T
Q
V
--
S
-
L
K
D
Q
I
T
S
G
--
K
--
Y
N
F
---
I
--
P
----
E
--
V
WAE-
V
S
E
K
--
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
---------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
239
Blastp_CBE
43.49
34%
-105
- C3 -
-
5XZV
4.8
-
RAD53_YEAST
A:
[199-465]
----------------
I
I
D
E
V
V
G
Q
G
A
F
A
T
V
K
K
A
I
E
R
T
T
G
K
T
F
A
V
K
I
I
S
----
K
R
K
V
--
I
G
N
M
D
G
-
V
T
R
E
L
E
V
L
Q
-
K
L
N
-
H
P
R
I
V
R
L
K
G
F
Y
E
D
T
E
S
Y
Y
M
V
M
E
F
V
S
G
G
D
L
M
D
F
V
A
A
H
G
A
V
G
E
D
A
G
R
E
I
S
R
Q
I
L
T
A
I
K
Y
I
H
S
M
G
I
S
H
R
D
L
K
P
D
N
I
L
---
I
EQ---
D
---
D
P
---
V
L
---
V
----
K
--
I
T
D
F
G
L
A
----
K
---------------------
L
A
Y
V
A
P
E
V
I
----------------NEYSSL-
V
D
M
W
S
M
G
C
L
V
Y
V
I
L
T
G
H
L
P
F
-----
S
T
Q
D
Q
--
L
-
Y
K
-
Q
I
G
R
G
--
S
--------
L
--
K
----
D
--
F
R---
I
S
E
E
--
A
R
D
F
I
D
S
L
---
D
P
N
N
-----------------
T
A
A
K
A
L
N
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
212
Blastp_CBE
43.49
37%
-83
- C3 -
-
2WTI
6.4
-
CHK2_HUMAN
A:
[17-287]
--------------
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
-------
P
A
L
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
----
K
--
I
T
D
F
G
H
S
----
K
I
-
L
----
E
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
---
S
E
H
R
T
Q
V
--
S
-
L
K
D
Q
I
T
S
G
--
K
--
Y
N
F
---
I
--
P
----
E
--
V
WAE-
V
S
E
K
--
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
---------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
210
Blastp_CBE
43.49
37%
-83
- C3 -
-
2XBJ
7.3
-
CHK2_HUMAN
A:
[17-287]
--------------
E
Y
I
M
S
K
T
L
G
S
G
A
-
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
--------
A
L
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
----
K
--
I
T
D
F
G
H
S
----
K
I
-
L
-----
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
---
S
E
H
R
T
Q
V
--
S
-
L
K
D
Q
I
T
S
G
--
K
--
Y
N
F
---
I
--
P
----
E
--
V
WAE-
V
S
E
K
--
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
---------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
359
Blastp_CBE
43.47
35%
-93
- C3 -
-
1STC
8.6
-
KAPCA_BOVIN
E:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
369
Blastp_CBE
43.45
35%
-92
- C3 -
-
3AG9
8.2
-
KAPCA_BOVIN
B:
[49-315]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
411
Blastp_CBE
43.44
34%
-91
- C3 -
-
3QAM
7.8
-
KAPCA_MOUSE
E:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
A
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
356
Blastp_CBE
43.43
35%
-91
- C3 -
-
1VEB
8.0
-
KAPCA_BOVIN
A:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
234
Blastp_CBE
43.39
34%
-106
- C3 -
-
4PDS
3.7
-
RAD53_YEAST
B:
[28-306]
----------------
I
I
D
E
V
---
G
A
F
A
T
V
K
K
A
I
E
R
T
T
G
K
T
F
S
V
K
I
I
------------------
V
T
R
E
L
E
V
L
Q
-
K
L
N
-
H
P
R
I
V
R
L
K
G
F
Y
-----
Y
Y
M
V
M
E
F
V
S
G
G
D
L
M
D
F
V
A
A
H
G
A
V
G
E
D
A
G
R
E
I
S
R
Q
I
L
T
A
I
K
Y
I
H
S
M
G
I
S
H
R
D
L
K
P
D
N
I
L
---
I
EQ---
D
---
D
P
---
V
L
---
V
----
K
--
I
T
A
F
G
L
A
----
K
V
-------------------
T
L
A
Y
V
A
P
E
V
I
----------------NEYSSL-
V
D
M
W
S
M
G
C
L
V
Y
V
I
L
T
G
H
L
P
F
---
S
G
S
T
Q
D
Q
--
L
-
Y
K
-
Q
I
G
R
G
--
S
--
Y
-
H
EGP
L
--
K
----
D
--
F
R---
I
S
E
E
--
A
R
D
F
I
D
S
L
L
Q
V
D
P
N
N
-----
R
-----
S
-----
T
A
A
K
A
L
N
H
P
W
I
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
204
Blastp_CBE
43.39
37%
-84
- C3 -
-
4A9U
6.5
-
CHK2_HUMAN
A:
[17-287]
--------------
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
------
D
P
A
L
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
----
K
--
I
T
D
F
G
H
S
----
K
I
-
L
-----
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
---
S
E
H
R
T
Q
V
--
S
-
L
K
D
Q
I
T
S
G
--
K
--
Y
N
F
---
I
--
P
----
E
--
V
WAE-
V
S
E
K
--
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
---------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
243
Blastp_CBE
43.33
39%
-100
- C3 -
-
2W4O
4.5
-
KCC4_HUMAN
A:
[61-308]
---------------------
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
L
K
----
K
----------------
I
G
V
L
L
-
R
L
S
-
H
P
N
I
I
K
L
K
E
I
F
E
T
P
T
E
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
K
G
Y
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
Y
ATPAP
D
---
A
P
---
L
---------
K
--
I
A
D
F
---------------------------
G
T
P
G
Y
C
A
P
E
I
L
R
G
C
A
Y
------
G
--
P
E
-------
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
---
Y
D
E
R
G
D
Q
F-
M
-
F
R
-
R
I
L
N
C
--
E
--
Y
-
Y
---
F
IS
P
----
W
--
W
DE--
V
S
L
N
--
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
-----
R
-----
L
-----
T
T
F
Q
A
L
Q
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
195
Blastp_CBE
43.32
37%
-83
- C3 -
-
4BDI
3.1
-
CHK2_HUMAN
A:
[17-287]
--------------
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
--------
A
L
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
----
K
--
I
T
D
F
G
H
S
----
K
I
-
L
---
G
E
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
---
S
E
H
R
T
Q
V
--
S
-
L
K
D
Q
I
T
S
G
--
K
--
Y
N
F
---
I
--
P
----
E
--
V
WAE-
V
S
E
K
--
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
---------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
187
Blastp_CBE
43.32
37%
-85
- C3 -
-
2YIR
7.1
-
CHK2_HUMAN
A:
[11-281]
--------------
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
---------
L
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
----
K
--
I
T
D
F
G
H
S
----
K
I
-
L
---
G
E
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
---
S
E
H
R
T
Q
V
--
S
-
L
K
D
Q
I
T
S
G
--
K
--
Y
N
F
---
I
--
P
----
E
--
V
WAE-
V
S
E
K
--
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
---------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
117
Blastp_CBE
43.30
39%
-85
- C3 -
-
4FG8
5.8
-
KCC1A_HUMAN
A:
[20-279]
---------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
----
K
-------------
E
N
E
I
A
V
L
H
-
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
-----
D
---
E
D
---
S
K
---
I
----
M
--
I
S
D
F
----------------------------
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
-----
K
--
A
--------
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
---
Y
D
E
N
D
A
K
--
L
-
F
E
-
Q
I
L
K
A
--
E
--
Y
-
E
---
F
DS
P
----
Y
--
W
DD--
I
S
D
S
--
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
-----
R
-----
F
-----
T
C
E
Q
A
L
Q
H
P
W
I
A
-----
G
---------
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
308
Blastp_CBE
43.26
35%
-93
- C3 -
-
3OW3
4.8
-
KAPCA_MOUSE
A:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
414
Blastp_CBE
43.19
35%
-87
- C3 -
-
2UW7
5.7
-
KAPCA_BOVIN
A:
[49-298]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
K
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
287
Blastp_CBE
43.15
35%
-88
- C3 -
-
3OWP
5.8
-
KAPCA_HUMAN
A:
[49-298]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
188
Blastp_CBE
43.17
37%
-86
- C3 -
-
2YIQ
7.4
-
CHK2_HUMAN
A:
[11-281]
--------------
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
------------
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
----
K
--
I
T
D
F
G
H
S
----
K
I
-
L
---
G
E
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
---
S
E
H
R
T
Q
V
--
S
-
L
K
D
Q
I
T
S
G
--
K
--
Y
N
F
---
I
--
P
----
E
--
V
WAE-
V
S
E
K
--
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
---------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
196
Blastp_CBE
43.16
37%
-90
- C3 -
-
4BDH
3.7
-
CHK2_HUMAN
A:
[17-287]
--------------
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
----------
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
----
K
--
I
T
D
F
G
H
S
----
K
I
-
L
---
G
E
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
---
S
E
H
R
T
Q
V
--
S
-
L
K
D
Q
I
T
S
G
--
K
--
Y
N
F
---
I
--
P
----
E
--
V
WAE-
V
S
E
K
--
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
---------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
209
Blastp_CBE
43.15
37%
-105
- C3 -
-
2XM8
6.1
-
CHK2_HUMAN
A:
[17-287]
--------------
E
Y
I
M
S
K
T
L
-----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-----------------
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
----
K
--
I
T
D
F
G
H
S
----
K
I
-
L
-----
T
---
S
L
M
R
T
L
C
G
---
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
---
S
E
H
R
T
Q
V
--
S
-
L
K
D
Q
I
T
S
G
--
K
--
Y
N
F
---
I
--
P
----
E
--
V
WAE-
V
S
E
K
--
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
---------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
333
Blastp_CBE
43.14
35%
-86
- C3 -
-
3MVJ
5.2
-
KAPCA_HUMAN
A:
[69-318]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
320
Blastp_CBE
43.13
35%
-89
- C3 -
-
2ERZ
5.1
-
KAPCA_MOUSE
E:
[49-298]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
242
Blastp_CBE
43.12
32%
-68
- C3 -
-
2QUR
5.1
-
KAPCA_MOUSE
A:
[48-342]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLP
N
-----
G
V
N
D
I
K
N
H
K
W
F
A
-----
T
---------
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
-
G
D
T
S
-
N
A
D
D
-
Y
--
E
E
E
E
I
R
V
I
N
E
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
297
Blastp_CBE
43.08
35%
-88
- C3 -
-
3AGL
8.5
-
KAPCA_HUMAN
B:
[49-298]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
158
Blastp_CBE
43.07
33%
-57
- C3 -
-
5DVR
3.4
-
?
A:
[75-505]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
--
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
SKD
A
N
---
I
----
R
--
I
I
D
F
G
L
S
----
T
H
-
F
---
E
A
----
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
G
A
N
E
Y
D
--
I
-
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
---
L
--
P
----
Q
--
W
KK--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
-----
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
---------
Y
------------------------
P
S
L
D
N
A
I
-
L
--
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
331
Blastp_CBE
43.00
35%
-92
- C3 -
-
3MVJ
4.8
-
KAPCA_HUMAN
E:
[69-318]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
205
Blastp_CBE
43.00
37%
-76
- C3 -
-
4A9T
6.2
-
CHK2_HUMAN
A:
[17-287]
--------------
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
-------
P
A
L
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
----
K
--
I
T
D
F
G
H
S
----
K
I
-
L
---
G
E
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
---
S
E
H
R
T
Q
V
--
S
-
L
K
D
Q
I
T
S
G
--
K
--
Y
N
F
---
I
--
P
----
E
--
V
WAE-
V
S
E
K
--
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
---------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
384
Blastp_CBE
42.94
35%
-57
- C3 -
-
4YSJ
6.1
-
?
B:
[38-310]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
V
T
G
Q
E
Y
A
V
K
V
I
S
----
K
R
-----------
L
L
K
E
V
E
L
L
K
-
K
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
NKR
K
D
---
A
N
---
I
----
R
--
I
I
D
F
G
L
S
----
T
H
-
F
---
E
S
T
---
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
G
A
N
E
F
D
--
I
-
L
K
-
K
V
E
K
G
KF
T
--
F
-
D
---
L
--
P
----
Q
--
W
KK--
V
S
E
P
--
A
K
D
L
I
R
K
M
L
A
Y
V
P
T
M
-----
R
-----
I
-----
S
A
R
D
A
L
E
H
E
W
L
K
-----
T
---------
T
--------------
D
A
--
D
S
I
-
D
V
P
S
L
E
S
T
I
-
L
--
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
486
Blastp_CBE
42.99
34%
-87
- C3 -
-
3FHI
8.2
-
KAPCA_MOUSE
A:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
A
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
362
Blastp_CBE
42.97
34%
-92
- C3 -
-
3O7L
5.5
-
KAPCA_MOUSE
B:
[48-301]
--------------------
T
L
G
T
G
---
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
I
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
I
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
118
Blastp_CBE
42.95
39%
-88
- C3 -
-
4FG9
6.2
-
KCC1A_HUMAN
B:
[20-279]
---------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
----
K
---------------
E
I
A
V
L
H
-
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
-----
D
---
E
D
---
S
K
---
I
----
M
--
I
S
D
F
---------------------
V
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
-----
K
--
A
--------
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
---
Y
D
E
N
D
A
K
--
L
-
F
E
-
Q
I
L
K
A
--
E
--
Y
-
E
---
F
DS
P
----
Y
--
W
DD--
I
S
D
S
--
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
-----
R
-----
F
-----
T
C
E
Q
A
L
Q
H
P
W
I
A
-----
G
---------
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
215
Blastp_CBE
42.94
37%
-92
- C3 -
-
2CN8
5.2
-
CHK2_HUMAN
A:
[17-287]
--------------
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
----------
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
----
K
--
I
T
D
F
G
H
S
----
K
I
-
L
-----
T
---
S
L
M
R
T
L
C
--
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
---
S
E
H
---
V
--
S
-
L
K
D
Q
I
T
S
G
--
K
--
Y
N
F
---
I
--
P
----
E
--
V
WAE-
V
S
E
K
--
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
---------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
207
Blastp_CBE
42.93
37%
-83
- C3 -
-
4A9R
4.1
-
CHK2_HUMAN
A:
[17-287]
--------------
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
-------
P
A
L
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
----
K
--
I
T
D
F
G
H
S
----
K
I
-
L
---
G
E
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
---
S
E
H
R
T
Q
V
--
S
-
L
K
D
Q
I
T
S
G
--
K
--
Y
N
F
---
I
--
P
----
E
--
V
WAE-
V
S
E
K
--
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
---------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
114
Blastp_CBE
42.93
39%
-86
- C3 -
-
4FG7
4.5
-
KCC1A_HUMAN
A:
[20-277]
---------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
---------------
S
-
M
E
N
E
I
A
V
L
H
-
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
-----
D
---
E
D
---
S
K
---
I
----
M
--
I
S
D
F
G
L
S
----
K
M
-
E
---
D
P
-----------
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
--
S
-----
K
--
A
--------
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
---
Y
D
E
N
D
A
K
--
L
-
F
E
-
Q
I
L
K
A
--
E
--
Y
-
E
---
F
DS
P
----
Y
--
W
DD--
I
S
D
S
--
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
-----
R
-----
F
-----
T
C
E
Q
A
L
Q
H
P
W
I
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
298
Blastp_CBE
42.90
35%
-88
- C3 -
-
3AGL
8.5
-
KAPCA_HUMAN
A:
[49-298]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
203
Blastp_CBE
42.88
37%
-87
- C3 -
-
4BDA
4.7
-
CHK2_HUMAN
A:
[17-287]
--------------
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
----------
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
---
S
Q
---
E
E
DCL
I
----
K
--
I
T
D
F
G
H
S
----
K
I
-
L
----
E
T
---
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
---
S
E
H
R
T
Q
V
--
S
-
L
K
D
Q
I
T
S
G
--
K
--
Y
N
F
---
I
--
P
----
E
--
V
WAE-
V
S
E
K
--
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
-----
R
-----
F
-----
T
T
E
E
A
L
R
H
P
W
L
Q
-----
D
---------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
541
Blastp_CBE
42.87
35%
-87
- C3 -
-
3NX8
3.5
-
KAPCA_HUMAN
A:
[49-298]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
N
-
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
Blastp_CBE
42.86
40%
-72
- C3 -
-
3F3Z
5.7
-
?
A:
[10-271]
--------------
Y
Y
T
L
E
N
T
I
G
R
G
S
W
G
E
V
K
I
A
V
Q
K
G
T
R
I
R
R
A
A
K
K
I
P
----
K
Y
F
V
E
D
V
D
---
R
-
F
K
Q
E
I
E
I
M
K
-
S
L
D
-
H
P
N
I
I
R
L
Y
E
T
F
E
D
N
T
D
I
Y
L
V
M
E
L
C
T
G
G
E
L
F
E
R
V
V
H
K
R
V
F
R
E
S
D
A
A
R
I
M
K
D
V
L
S
A
V
A
Y
C
H
K
L
N
V
A
H
R
D
L
K
P
E
N
F
L
---
F
LTD--
S
---
P
D
---
S
P
---
L
----
K
--
L
I
D
F
G
L
A
----
A
R
-
F
---
K
P
G
---
K
M
M
R
T
K
V
G
T
P
Y
Y
V
S
P
Q
V
L
E
G
-
L
Y
------
G
--
P
E
-------
C
D
E
W
S
A
G
V
M
M
Y
V
L
L
C
G
Y
P
P
F
---
S
---
A
P
T
DE
V
-
M
L
-
K
I
R
E
G
--
T
--
F
-
T
---
F
--
P
----
E
KD
W
----
L
N
V
S
PQ
A
E
S
L
I
R
R
L
L
T
K
S
P
K
Q
-----
R
-----
I
-----
T
S
L
Q
A
L
E
H
E
W
F
E
-----
K
---------
Q
--------------
L
S
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
554
Blastp_CBE
42.77
35%
-78
- C3 -
-
4FTU
7.0
-
CHK1_HUMAN
A:
[8-268]
---------------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
----
M
----------
N
-
I
K
K
E
I
C
I
N
K
-
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
-----
D
---
E
R
---
D
N
---
L
----
K
--
I
S
D
F
G
L
A
----
T
V
-
F
RYN
N
R
E
---
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
--
E
P
-------
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
---
D
Q
P
S
D
S
C
--
Q
E
Y
S
-
D
W
K
E
K
--
K
--
T
-
Y
---
L
--
N
----
P
--
W
KK--
I
D
S
A
--
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
-----
R
-----
I
-----
T
I
P
D
I
K
K
D
R
W
Y
N
-----
K
---------
P
--------------
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
318
Blastp_CBE
42.74
35%
-90
- C3 -
-
1ATP
8.7
-
KAPCA_MOUSE
E:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
409
Blastp_CBE
42.71
35%
-88
- C3 -
-
1XHA
8.7
-
KAPCA_BOVIN
A:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
E
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
L
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
218
Blastp_CBE
42.37
35%
-81
- C3 -
-
4MVF
7.9
-
CDPK2_PLAFK
A:
[51-323]
------
H
S
G
K
L
E
-
D
K
Y
I
I
D
E
K
L
G
Q
G
T
Y
G
C
V
Y
K
G
I
D
K
V
T
N
Q
L
Y
A
I
K
E
E
K
----
K
D
R
L
K
N
---
I
N
R
-
F
F
Q
E
I
E
I
M
K
-
K
L
D
-
H
P
N
I
V
K
L
Y
E
T
Y
E
N
D
N
Y
I
Y
L
I
M
E
L
C
S
G
R
E
L
F
D
S
I
I
E
N
G
S
F
T
E
K
N
A
A
T
I
M
K
Q
I
F
S
A
I
F
Y
L
H
S
L
N
I
V
H
R
D
L
K
P
E
N
F
L
---
F
-----
Q
---
S
E
---
N
K
DSL
L
----
K
--
I
I
D
F
G
L
S
----
K
N
-
L
-----------------------------
K
Y
-------
D
--
K
K
-------
C
D
I
W
S
S
G
V
I
M
Y
T
L
L
C
G
Y
P
P
F
---
Y
-------------------------
C
---
F
--
Y
----
E
--
N
DWGS
I
S
S
D
--
A
K
N
L
I
T
K
L
L
T
Y
N
P
N
E
-----
R
-----
C
-----
T
I
E
E
A
L
N
H
P
W
I
T
-----
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
164
Blastp_CBE
42.21
40%
-82
- C3 -
-
2JAM
6.3
-
KCC1G_HUMAN
A:
[11-264]
---------------
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
----
K
---------
S
S
-
L
E
N
E
I
A
V
L
K
-
K
I
K
-
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
G
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y--
L
-----
T
---
P
E
---
E
N
---
S
----
K
IM
I
T
D
F
G
L
S
----
K
M
-
E
---
Q
N
G
----
I
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
-----
K
--
A
--------
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
---
Y
E
E
T
E
S
K
--
L
-
F
E
-
K
I
K
E
G
--
Y
YE
F
-
E
---
S
--
P
----
F
--
W
DD--
I
S
E
S
--
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
-----
R
-----
Y
-----
T
C
E
K
A
L
S
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
552
Blastp_CBE
41.76
35%
-71
- C3 -
-
4FSN
7.8
-
CHK1_HUMAN
A:
[7-267]
---------------
W
D
L
V
Q
T
L
G
E
G
A
-
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
----
M
---------
E
N
-
I
K
K
E
I
C
I
N
K
-
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
-----
D
---
E
R
---
D
N
---
L
----
K
--
I
S
D
F
G
L
A
----
T
V
-
F
RYN
N
R
E
---
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
--
E
P
-------
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
---
D
Q
P
S
D
S
C
--
Q
E
Y
S
-
D
W
K
E
K
--
K
--
T
-
Y
---
L
--
N
----
P
--
W
KK--
I
D
S
A
--
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
-----
R
-----
I
-----
T
I
P
D
I
K
K
D
R
W
Y
N
-----
K
---------
P
--------------
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
163
Blastp_CBE
41.69
40%
-77
- C3 -
-
2JAM
5.9
-
KCC1G_HUMAN
B:
[11-264]
---------------
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
----
K
---------
S
S
-
L
E
N
E
I
A
V
L
K
-
K
I
K
-
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
G
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y--
L
-----
T
---
P
E
---
E
N
---
S
----
K
IM
I
T
D
F
G
L
S
----
K
M
-
E
---
Q
N
G
----
I
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
-----
K
--
A
--------
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
---
Y
E
E
T
E
S
K
--
L
-
F
E
-
K
I
K
E
G
--
Y
YE
F
-
E
---
S
--
P
----
F
--
W
DD--
I
S
E
S
--
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
-----
R
-----
Y
-----
T
C
E
K
A
L
S
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
235
Blastp_CBE
41.33
34%
-92
- C3 -
-
4PDS
5.1
-
RAD53_YEAST
A:
[34-305]
----------------
I
I
D
E
V
-------
T
V
K
K
A
I
E
R
T
T
G
K
T
F
S
V
K
I
I
------------------
V
T
R
E
L
E
V
L
Q
-
K
L
N
-
H
P
R
I
V
R
L
K
G
F
Y
---
E
S
Y
Y
M
V
M
E
F
V
S
G
G
D
L
M
D
F
V
A
A
H
G
A
V
G
E
D
A
G
R
E
I
S
R
Q
I
L
T
A
I
K
Y
I
H
S
M
G
I
S
H
R
D
L
K
P
D
N
I
L
---
I
EQ---
D
---
D
P
---
V
L
---
V
----
K
--
I
T
A
F
G
L
A
----
K
V
---------------------
A
Y
V
A
P
E
V
I
R
---------------RNEYSSL
V
D
M
W
S
M
G
C
L
V
Y
V
I
L
T
G
H
L
P
F
---
S
G
S
T
Q
D
Q
--
L
-
Y
K
-
Q
I
G
R
G
--
S
--
Y
-
H
EGP
L
--
K
----
D
--
F
R---
I
S
E
E
--
A
R
D
F
I
D
S
L
L
Q
V
D
P
N
N
-----
R
-----
S
-----
T
A
A
K
A
L
N
H
P
W
I
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
527
Blastp_CBE
41.29
37%
-56
- C3 -
-
3LIJ
4.0
-
?
A:
[45-303]
---------------------
L
G
S
---
G
E
V
L
L
C
R
D
K
V
T
H
V
E
R
A
I
K
I
I
R
----
K
------
S
S
N
S
K
-
L
L
E
E
V
A
V
L
K
-
L
L
D
-
H
P
N
I
M
K
L
Y
D
F
F
E
D
K
R
N
Y
Y
L
V
M
E
C
Y
K
G
G
E
L
F
D
E
I
I
H
R
M
K
F
N
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
---
S
K
---
E
K
DAL
I
----
K
--
I
V
D
F
G
L
S
----
A
V
-
F
---
E
N
Q
---
K
K
M
K
E
R
L
G
T
A
Y
Y
I
A
P
E
V
L
--
R
K
K
Y
-----
D
--
E
K
-------
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
---
G
G
Q
T
D
Q
E
--
I
-
L
R
-
K
V
E
K
G
KY
T
--
F
-
D
---
S
--
P
----
E
--
W
----
K
N
V
S
EG
A
K
D
L
I
K
Q
M
L
Q
F
D
S
Q
R
-----
R
-----
I
-----
S
A
Q
Q
A
L
E
H
P
W
I
K
-----
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
472
Blastp_CBE
40.76
34%
-66
- C3 -
-
5N39
1.6
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
468
Blastp_CBE
40.57
34%
-65
- C3 -
-
5N3D
3.2
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
471
Blastp_CBE
40.50
34%
-66
- C3 -
-
5N3A
Error
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
476
Blastp_CBE
40.40
34%
-71
- C3 -
-
5N1O
3.1
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
-
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
467
Blastp_CBE
40.37
34%
-66
- C3 -
-
5N3E
2.2
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
462
Blastp_CBE
40.34
34%
-65
- C3 -
-
5N3J
2.0
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
473
Blastp_CBE
40.26
34%
-69
- C3 -
-
5N37
2.0
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
430
Blastp_CBE
40.12
34%
-70
- C3 -
-
6ESA
2.5
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
479
Blastp_CBE
40.04
34%
-65
- C3 -
-
5N1L
2.6
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
482
Blastp_CBE
39.95
34%
-67
- C3 -
-
5N1F
0.2
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
423
Blastp_CBE
39.95
34%
-70
- C3 -
-
6EM7
3.2
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
474
Blastp_CBE
39.91
34%
-64
- C3 -
-
5N36
1.8
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
469
Blastp_CBE
39.89
34%
-63
- C3 -
-
5N3C
1.2
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
480
Blastp_CBE
39.88
34%
-66
- C3 -
-
5N1H
3.3
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
437
Blastp_CBE
39.87
34%
-71
- C3 -
-
6EMA
3.7
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
449
Blastp_CBE
39.85
34%
-70
- C3 -
-
5OK3
2.1
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
446
Blastp_CBE
39.83
34%
-72
- C3 -
-
5OTG
3.3
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
470
Blastp_CBE
39.73
34%
-66
- C3 -
-
5N3B
2.3
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
422
Blastp_CBE
39.73
34%
-72
- C3 -
-
5NW8
3.0
-
KAPCA_CRIGR
A:
[39-298]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
232
Blastp_CBE
39.60
38%
-28
- C3 -
-
2Y7J
6.0
-
PHKG2_HUMAN
B:
[100-365]
-------------------
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
VTA---
S
P
E
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
-
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
-----
D
---
D
N
---
M
Q
---
I
----
R
--
L
S
D
F
G
F
S
----
C
H
-
L
---
E
P
G
---
E
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
D
E
THPGY
G
--
K
E
-------
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
---
W
H
R
R
Q
I
L
--
M
-
L
R
-
M
I
M
E
G
QY
Q
--
F
-
S
---
S
--
P
----
E
--
W
----
D
D
R
S
ST
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
-----
R
-----
L
-----
T
A
E
Q
A
L
Q
H
P
F
F
E
-----
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
465
Blastp_CBE
39.59
34%
-65
- C3 -
-
5N3G
1.1
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
436
Blastp_CBE
39.45
34%
-72
- C3 -
-
6EMB
2.5
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
460
Blastp_CBE
39.50
34%
-63
- C3 -
-
5N3L
2.4
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
456
Blastp_CBE
39.47
34%
-65
- C3 -
-
5N3Q
2.6
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
433
Blastp_CBE
39.45
34%
-68
- C3 -
-
6ERT
2.5
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
442
Blastp_CBE
39.27
34%
-66
- C3 -
-
6EGW
5.7
-
KAPCA_CRIGR
A:
[41-301]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
---
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
457
Blastp_CBE
39.23
34%
-63
- C3 -
-
5N3P
2.8
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
475
Blastp_CBE
39.13
34%
-65
- C3 -
-
5N33
1.9
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
454
Blastp_CBE
39.14
34%
-64
- C3 -
-
5N3S
2.9
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
439
Blastp_CBE
39.13
34%
-65
- C3 -
-
6EM2
2.9
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
484
Blastp_CBE
39.12
35%
-73
- C3 -
-
4FT3
5.7
-
CHK1_HUMAN
A:
[8-268]
---------------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
----
M
---------
E
N
-
I
K
K
E
I
C
I
N
K
-
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
-----
D
---
E
R
---
D
N
---
L
----
K
--
I
S
D
F
G
L
A
----
T
V
-
F
RY-
N
N
R
---
E
R
L
L
N
K
M
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
--
E
P
-------
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
---
D
Q
P
S
D
S
Q
--
E
-
Y
S
-
D
W
K
E
K
--
K
--
T
-
Y
---
L
--
N
----
P
--
W
KK--
I
D
S
A
--
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
-----
R
-----
I
-----
T
I
P
D
I
K
K
D
R
W
Y
N
-----
K
---------
P
--------------
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
458
Blastp_CBE
39.09
34%
-60
- C3 -
-
5N3O
2.3
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
435
Blastp_CBE
39.06
34%
-63
- C3 -
-
6EMD
4.7
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
508
Blastp_CBE
39.04
35%
-61
- C3 -
-
4X6R
3.4
-
KAPCA_MOUSE
A:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
481
Blastp_CBE
39.03
34%
-67
- C3 -
-
5N1G
3.7
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
426
Blastp_CBE
39.01
34%
-63
- C3 -
-
6I2D
4.7
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
448
Blastp_CBE
39.00
34%
-66
- C3 -
-
5OL3
5.3
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
489
Blastp_CBE
38.96
35%
-64
- C3 -
-
4WB5
4.7
-
KAPCA_HUMAN
A:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
452
Blastp_CBE
38.93
34%
-70
- C3 -
-
5NTJ
3.4
-
KAPCA_CRIGR
A:
[41-303]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
447
Blastp_CBE
38.91
34%
-67
- C3 -
-
5OT3
4.3
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
513
Blastp_CBE
38.82
35%
-67
- C3 -
-
4XW6
3.2
-
KAPCA_MOUSE
A:
[54-303]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
464
Blastp_CBE
38.75
34%
-62
- C3 -
-
5N3H
3.5
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
450
Blastp_CBE
38.81
34%
-65
- C3 -
-
5O5M
5.1
-
KAPCA_CRIGR
A:
[41-302]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
496
Blastp_CBE
38.80
35%
-65
- C3 -
-
4HPU
2.9
-
KAPCA_MOUSE
E:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
438
Blastp_CBE
38.75
34%
-65
- C3 -
-
6EM6
2.7
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
427
Blastp_CBE
38.67
34%
-67
- C3 -
-
6I2C
3.0
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
--
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
521
Blastp_CBE
38.63
35%
-64
- C3 -
-
4IAK
4.3
-
KAPCA_MOUSE
A:
[54-303]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
526
Blastp_CBE
38.52
35%
-65
- C3 -
-
4WB8
6.0
-
KAPCA_HUMAN
A:
[35-284]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
525
Blastp_CBE
38.50
35%
-60
- C3 -
-
4IAC
3.8
-
KAPCA_MOUSE
A:
[54-303]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
434
Blastp_CBE
38.48
34%
-67
- C3 -
-
6ERS
3.0
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
--
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
539
Blastp_CBE
38.47
35%
-64
- C3 -
-
2JDS
2.7
-
KAPCA_BOVIN
A:
[49-298]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
428
Blastp_CBE
38.46
34%
-62
- C3 -
-
6I2B
5.7
-
KAPCA_CRIGR
A:
[41-302]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
533
Blastp_CBE
38.41
35%
-63
- C3 -
-
1XH4
Error
-
KAPCA_BOVIN
A:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
505
Blastp_CBE
38.38
35%
-62
- C3 -
-
3X2W
4.0
-
KAPCA_MOUSE
A:
[55-304]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
230
Blastp_CBE
38.32
38%
-18
- C3 -
-
2Y7J
6.2
-
PHKG2_HUMAN
D:
[100-365]
-------------------
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V---
R
L
S
P
E
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
-
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
-----
D
---
D
N
---
M
Q
---
I
----
R
--
L
S
D
F
G
F
S
----
C
H
-
L
---
E
P
G
---
E
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
D
E
THPGY
G
--
K
E
-------
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
---
W
H
R
R
Q
I
L
--
M
-
L
R
-
M
I
M
E
G
QY
Q
--
F
-
S
---
S
--
P
----
E
--
W
----
D
D
R
S
ST
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
-----
R
-----
L
-----
T
A
E
Q
A
L
Q
H
P
F
F
E
-----
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
524
Blastp_CBE
38.29
35%
-61
- C3 -
-
4IAD
4.1
-
KAPCA_MOUSE
A:
[54-303]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
510
Blastp_CBE
38.27
35%
-64
- C3 -
-
4DFX
3.6
-
KAPCA_MOUSE
E:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
498
Blastp_CBE
38.26
35%
-63
- C3 -
-
4DH7
3.5
-
KAPCA_MOUSE
A:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
522
Blastp_CBE
38.23
35%
-62
- C3 -
-
4IAI
4.0
-
KAPCA_MOUSE
A:
[54-303]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
532
Blastp_CBE
38.22
35%
-64
- C3 -
-
3BWJ
4.1
-
KAPCA_BOVIN
A:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
537
Blastp_CBE
38.19
35%
-62
- C3 -
-
3ZO3
5.1
-
KAPCA_BOVIN
A:
[49-298]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
490
Blastp_CBE
38.17
35%
-56
- C3 -
-
4WB6
4.7
-
KAPCA_HUMAN
A:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
R
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
483
Blastp_CBE
38.11
35%
-72
- C3 -
-
4GH2
8.0
-
CHK1_HUMAN
A:
[8-268]
---------------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
----------------
N
-
I
K
K
E
I
C
I
N
K
-
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
-----
D
---
E
R
---
D
N
---
L
----
K
--
I
S
D
F
G
L
A
----
T
V
-
F
RY-
N
N
R
---
E
R
L
L
N
K
M
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
--
E
P
-------
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
---
D
Q
P
S
D
S
Q
--
E
-
Y
S
-
D
W
K
E
K
--
K
--
T
-
Y
---
L
--
N
----
P
--
W
KK--
I
D
S
A
--
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
-----
R
-----
I
-----
T
I
P
D
I
K
K
D
R
W
Y
N
-----
K
---------
P
--------------
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
503
Blastp_CBE
38.07
35%
-63
- C3 -
-
4DG0
2.8
-
KAPCA_MOUSE
E:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
517
Blastp_CBE
38.06
35%
-64
- C3 -
-
4IB1
4.2
-
KAPCA_MOUSE
A:
[54-303]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
538
Blastp_CBE
38.03
35%
-66
- C3 -
-
3ZO1
4.0
-
KAPCA_BOVIN
A:
[49-298]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
499
Blastp_CBE
38.00
35%
-57
- C3 -
-
4DH5
2.9
-
KAPCA_MOUSE
A:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
507
Blastp_CBE
37.98
35%
-63
* C3 *
-
3X2U
3.1
-
KAPCA_MOUSE
A:
[55-304]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
536
Blastp_CBE
37.97
35%
-62
- C3 -
-
5VHB
1.6
-
KAPCA_BOVIN
A:
[49-303]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
519
Blastp_CBE
37.93
35%
-62
- C3 -
-
4IAZ
2.7
-
KAPCA_MOUSE
A:
[54-303]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
518
Blastp_CBE
37.86
35%
-59
- C3 -
-
4IB0
4.4
-
KAPCA_MOUSE
A:
[54-303]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
500
Blastp_CBE
37.84
35%
-63
- C3 -
-
4DH3
3.4
-
KAPCA_MOUSE
A:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
516
Blastp_CBE
37.80
35%
-61
- C3 -
-
4IB3
5.2
-
KAPCA_MOUSE
A:
[54-303]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
520
Blastp_CBE
37.72
35%
-62
- C3 -
-
4IAY
3.9
-
KAPCA_MOUSE
A:
[54-303]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
540
Blastp_CBE
37.77
35%
-61
- C3 -
-
1XH7
0.7
-
KAPCA_BOVIN
A:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
531
Blastp_CBE
37.76
35%
-59
- C3 -
-
3KKV
Error
-
KAPCA_BOVIN
A:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
504
Blastp_CBE
37.72
35%
-60
- C3 -
-
2QCS
5.0
-
KAPCA_MOUSE
A:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
529
Blastp_CBE
37.66
35%
-61
- C3 -
-
4O21
2.6
-
KAPCA_MOUSE
A:
[40-289]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
535
Blastp_CBE
37.65
35%
-65
- C3 -
-
3ZO2
3.6
-
KAPCA_BOVIN
A:
[49-298]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
523
Blastp_CBE
37.62
35%
-60
- C3 -
-
4IAF
4.0
-
KAPCA_MOUSE
A:
[54-303]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
534
Blastp_CBE
37.61
35%
-65
- C3 -
-
1Q8W
2.8
-
KAPCA_BOVIN
A:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
514
Blastp_CBE
37.60
35%
-63
- C3 -
-
4XW5
4.1
-
KAPCA_MOUSE
A:
[54-303]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
506
Blastp_CBE
37.36
35%
-62
- C3 -
-
3X2V
3.7
-
KAPCA_MOUSE
A:
[55-304]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
530
Blastp_CBE
37.35
35%
-61
- C3 -
-
4DG3
4.0
-
KAPCA_MOUSE
E:
[69-318]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
231
Blastp_CBE
37.15
38%
-10
- C3 -
-
2Y7J
5.9
-
PHKG2_HUMAN
C:
[100-365]
-------------------
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
VTAE
R
L
S
P
E
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
-
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
-----
D
---
D
N
---
M
Q
---
I
----
R
--
L
S
D
F
G
F
S
----
C
H
-
L
---
E
P
G
---
E
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
D
E
THPGY
G
--
K
E
-------
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
---
W
H
R
R
Q
I
L
--
M
-
L
R
-
M
I
M
E
G
QY
Q
--
F
-
S
---
S
--
P
----
E
--
W
----
D
D
R
S
ST
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
-----
R
-----
L
-----
T
A
E
Q
A
L
Q
H
P
F
F
E
-----
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
494
Blastp_CBE
37.14
35%
-63
- C3 -
-
5JR7
3.7
-
KAPCA_MOUSE
A:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
233
Blastp_CBE
37.13
38%
-11
- C3 -
-
2Y7J
6.5
-
PHKG2_HUMAN
A:
[100-365]
-------------------
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
VTAE
R
L
S
P
E
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
-
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
-----
D
---
D
N
---
M
Q
---
I
----
R
--
L
S
D
F
G
F
S
----
C
H
-
L
---
E
P
G
---
E
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
D
E
THPGY
G
--
K
E
-------
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
---
W
H
R
R
Q
I
L
--
M
-
L
R
-
M
I
M
E
G
QY
Q
--
F
-
S
---
S
--
P
----
E
--
W
----
D
D
R
S
ST
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
-----
R
-----
L
-----
T
A
E
Q
A
L
Q
H
P
F
F
E
-----
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
491
Blastp_CBE
37.04
35%
-59
- C3 -
-
3TNQ
4.7
-
KAPCA_MOUSE
B:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
515
Blastp_CBE
36.96
35%
-57
- C3 -
-
4XW4
4.3
-
KAPCA_MOUSE
A:
[54-303]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
551
Blastp_CBE
36.87
35%
-60
- C3 -
-
6FRX
5.2
-
KAPCA_HUMAN
A:
[49-303]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
Q
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
K
--
V
A
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
495
Blastp_CBE
36.52
35%
-60
- C3 -
-
4WBB
3.5
-
KAPCA_MOUSE
B:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
511
Blastp_CBE
36.49
35%
-63
- C3 -
-
3PVB
1.8
-
KAPCA_MOUSE
A:
[43-292]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
512
Blastp_CBE
36.28
35%
-59
- C3 -
-
6E21
3.0
-
KAPCA_MOUSE
A:
[54-303]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
493
Blastp_CBE
36.13
35%
-59
- C3 -
-
5JR7
1.8
-
KAPCA_MOUSE
C:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
545
Blastp_CBE
35.87
35%
-46
- C3 -
-
4WB7
5.0
-
KAPCA_HUMAN
B:
[103-352]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
546
Blastp_CBE
35.76
35%
-46
- C3 -
-
4WB7
5.7
-
DNJB1_HUMAN (first)
A:
[103-352]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
429
Blastp_CBE
31.62
34%
-73
- C3 -
-
6I2A
Error
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
451
Blastp_CBE
31.50
34%
-72
- C3 -
-
5O0E
Error
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
444
Blastp_CBE
31.48
34%
-72
- C3 -
-
5OUC
Error
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
440
Blastp_CBE
31.45
34%
-71
- C3 -
-
6EH3
Error
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
425
Blastp_CBE
31.25
34%
-70
- C3 -
-
6I2H
Error
-
?
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
431
Blastp_CBE
30.97
34%
-71
- C3 -
-
6ERW
Error
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
---
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
466
Blastp_CBE
30.79
34%
-69
- C3 -
-
5N3F
Error
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
--
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
-
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
441
Blastp_CBE
30.74
34%
-72
- C3 -
-
6EH2
Error
-
KAPCA_CRIGR
A:
[41-305]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
---
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
478
Blastp_CBE
30.73
34%
-65
- C3 -
-
5N1M
Error
-
KAPCA_CRIGR
A:
[41-300]
----------
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
501
Blastp_CBE
29.61
35%
-65
- C3 -
-
4DH1
Error
-
KAPCA_MOUSE
A:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
492
Blastp_CBE
29.25
35%
-62
- C3 -
-
1L3R
Error
-
KAPCA_MOUSE
E:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
497
Blastp_CBE
28.91
35%
-59
- C3 -
-
4DH8
Error
-
KAPCA_MOUSE
A:
[48-297]
--------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
-
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
---
Q
Q
---
G
Y
---
I
----
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
---
K
G
R
---
T
W
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
-------
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
Q
--
I
-
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
---
F
--
P
----
S
--
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-----
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
549
Blastp_CBE
22.30
35%
-22
- C3 -
-
4FSY
Error
-
CHK1_HUMAN
A:
[8-268]
---------------
W
D
L
V
Q
T
L
G
E
G
--
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
--------------
P
E
N
-
I
K
K
E
I
I
N
-
K
-
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
-----
D
---
E
R
---
D
N
---
L
----
K
--
I
S
D
F
G
L
A
----
T
V
-
F
RYN
N
R
E
---
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
--
E
P
-------
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
---
D
Q
P
S
D
S
C
--
Q
E
Y
S
-
D
W
K
E
K
--
K
--
T
-
Y
---
L
--
N
----
P
--
W
KK--
I
D
S
A
--
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
-----
R
-----
I
-----
T
I
P
D
I
K
K
D
R
W
Y
N
-----
K
---------
P
--------------
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
:
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
:
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------