@TOME V3
(Feb 2022)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Screening
Virtual Screening Score
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ACK1_HUMAN: (2020-09-03 )
MQPEEGTGWLLELLSEVQLQQYFLRLRDDLNVTRLSHFEYVKNEDLEKIGMGRPGQRRLWEAVKRRKALCKRKSWMSKVFSGKRLEAEFPPHHSQSTFRKTSPAPGGPAGEGPLQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRALQDFEEPDKLHIQMNDVITVIEGRAENYWWRGQNTRTLCVGPFPRNVVTSVAGLSAQDISQPLQNSFIHTGHGDSDPRHCWGFPDRIDELYLGNPMDPPDLLSVELSTSRPPQHLGGVKKPTYDPVSEDQDPLSSDFKRLGLRKPGLPRGLWLAKPSARVPGTKASRGSGAEVTLIDFGEEPVVPALRPCAPSLAQLAMDACSLLDETPPQSPTRALPRPLHPTPVVDWDARPLPPPPAYDDVAQDEDDFEICSINSTLVGAGVPAGPSQGQTNYAFVPEQARPPPPLEDNLFLPPQGGGKPPSSAQTAEIFQALQQECMRQLQAPAGSPAPSPSPGGDDKPQVPPRVPIPPRPTRPHVQLSPAPPGEEETSQWPGPASPPRVPPREPLSPQGSRTPSPLVPPGSSPLPPRLSSSPGKTMPTTQSFASDPKYATPQVIQAPGPRAGPCILPIVRDGKKVSSTHYYLLPERPSYLERYQRFLREAQSPEEPTPLPVPLLLPPPSTPAPAAPTATVRPMPQAALDPKANFSTNNSNPGARPPPPRATARLPQRGCPGDGPEAGRPADKIQMAMVHGVTTEECQAALQCHGWSVQRAAQYLKVEQLFGLGLRPRGECHKVLEMFDWNLEQAGCHLLGSWGPAHHKR
Atome Classification :
(365 SA)
.........10........20........30........40........50........60........70........80.......-.90........100.......110.......120--.........130.......140.......---150..--.-....160-.......170.......180..-.....190...-.-.-.-.---200........210.......220-----.-...-..-..230-.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330-------......---..----.340..--.....350.......360.......370......--.380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(pKd)
(pKd)
(Uniprot)
MQPEEGT
G
W
L
L
E
L
L
S
E
V
Q
L
Q
Q
Y
F
L
R
L
RDDLN
V
T
R
L
S
H
F
E
Y
V
K
NE
D
L
E
K
IGMGRP
G
Q
R
R
L
W
E
A
V
K
R
R
K
A
L
C
K
R
K
S
W
M
S
K
V
FSGKRLEAE-FPPHHSQSTFRKTSPAPGGPAGE
G
P
L
Q
S
L
T
C
L
----IG
E
K
D
L
R
L
L
E
K
LGDG
S
F
G
V
V
RRGEWDAPS---G
K
T
V
S
--
V
-
A
V
K
CLK
P
-
D
VLSQ
P
E
A
M
D
D
F
I
R
E
V
N
A
M
HSL-
D
H
R
N
L
I
R
L
Y
G
V
-
V
-L-T-
P
---
P
-
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
HQ------G-H
F
L
-
L
G
-
T
L
S
R
Y
-
A
V
Q
V
A
E
GM
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
IG
D
F
G
L
M
R
ALPQNDD
H
Y
V
M
Q
E
HRKV
P
F
A
WCAPESLKTRTFSHASD
T
W
M
F
G
V
T
L
W
E
M
F
TYGQE
P
---------
W
IGL
N
G
---
S
Q
----
I
L
H
K
I
D--KEGERLPRPEDC
P
Q
D
I
Y
N
V
M
V
Q
C
WAHKPEDR
P
T
F
--
V
A
L
R
D
F
L
LEAQP
T
D
M
R
A
L
Q
DFEEP
D
K
L
H
I
Q
MN
D
V
I
T
V
IEGRAEN
Y
W
WRGQN
T
R
T
L
C
VGPF
P
R
N
V
V
T
S
V
AGL
S
A
Q
D
I
S
Q
P
L
Q
NS
F
I
HTGHGDSDPRHCWGF
P
D
R
I
D
E
L
YLGNPMDPP
D
L
L
S
V
ELSTSR
P
P
Q
H
LGGVKKPTYDPVSEDQD
P
L
S
S
D
F
K
R
LGLRKPGLPR
G
L
W
LAKPSARVPGTKASRGSG
A
E
V
T
L
I
DFGEEPVVPALRPC
A
P
S
L
A
Q
L
A
M
D
A
C
S
L
L
DETPPQSPTRALPRPLHPTPVVDWDARPLPPPPAYDDVAQDEDD
F
E
I
C
SINS
T
L
VGAGVPAGPSQGQT
N
Y
A
FVPEQARPPPPLEDNLFLPPQGGGKPPSS
A
Q
T
A
E
I
F
Q
A
L
Q
Q
E
C
M
R
Q
LQAPAGSPAPSPSPGGDDKPQVPPRVPIPPRPTRP
H
V
Q
LSPAPPGEEETSQWPGPASPPRVPPREPLSPQGSRTPSPLVPPGSSPLPPRLSSSPGKTMPT
T
Q
SFASDPKYATP
Q
V
IQAPGPRAG
P
C
I
L
P
I
VRDGKKVSS
T
H
Y
Y
LLPER
P
S
Y
L
E
R
Y
Q
R
F
L
R
EAQSPEEPTPLPV
P
L
L
LPPPSTPAPAAPTATVRPMPQAALDPKANFSTNNSNPGARPPPP
R
A
TARLPQRGCPGDGPEAGR
P
A
D
K
I
Q
M
A
M
VHGV
T
T
E
E
C
Q
A
A
L
Q
CHG
W
S
V
Q
R
A
A
Q
Y
L
K
V
E
Q
L
FGLGLRP
R
G
E
C
H
K
V
L
E
M
F
DWNL
E
Q
AG
C
H
L
LGSWGPAHHKR
1
PsiBlast_PDB
91.66
100%
-110
- C5 -
-
4HZS
-
-
ACK1_HUMAN
A:
[115-446]
-------------------------------------------------------------------------------------------------------------------
Q
S
L
T
C
L
----
I
G
E
K
D
L
R
L
L
E
K
L
G
D
G
S
F
G
V
V
R
R
G
E
W
D
A
P
S
---
G
K
T
V
S
--
V
-
A
V
K
C
L
K
P
-
D
V
L
S
Q
P
E
A
M
D
D
F
I
R
E
V
N
A
M
H
S
L
-
D
H
R
N
L
I
R
L
Y
G
V
-
V
-
L
-
T
-
P
---
P
-
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
H
Q
------
G
-
H
F
L
-
L
G
-
T
L
S
R
Y
-
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
G
L
M
R
A
L
P
-------------
V
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
---------
W
I
G
L
N
G
---
S
Q
----
I
L
H
K
I
D
--
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
--
V
A
L
R
D
F
L
L
E
A
Q
P
T
D
M
R
A
L
Q
D
F
E
E
P
D
K
L
H
I
Q
M
N
D
V
I
T
V
I
E
G
R
A
E
N
Y
W
W
R
G
Q
N
T
R
T
L
C
V
G
P
F
P
R
N
V
V
T
S
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
537
HHSearch
89.77
100%
-108
- C5 -
-
4HZS
-
-
ACK1_HUMAN
B:
[119-446]
-----------------------------------------------------------------------------------------------------------------------
C
L
----
I
G
E
K
D
L
R
L
L
E
K
L
G
D
G
S
F
G
V
V
R
R
G
E
W
D
A
P
S
---
G
K
T
V
S
--
V
-
A
V
K
C
L
K
P
-
D
V
L
S
Q
P
E
A
M
D
D
F
I
R
E
V
N
A
M
H
S
L
-
D
H
R
N
L
I
R
L
Y
G
V
-
V
-
L
-
T
-
P
---
P
-
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
H
Q
------
G
-
H
F
L
-
L
G
-
T
L
S
R
Y
-
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
G
L
M
R
A
L
P
-------------
V
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
---------
W
I
G
L
N
G
---
S
Q
----
I
L
H
K
I
D
--
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
--
V
A
L
R
D
F
L
L
E
A
Q
P
T
D
M
R
A
L
Q
D
F
E
E
P
D
K
L
H
I
Q
M
N
D
V
I
T
V
I
E
G
R
A
E
N
Y
W
W
R
G
Q
N
T
R
T
L
C
V
G
P
F
P
R
N
V
V
T
S
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Blastp_CBE
82.95
100%
-116
- C5 -
-
3EQR
9.5
-
ACK1_HUMAN
B:
[1-274]
---------------------------------------------------------------------------------------------------------------------
L
T
C
L
----
I
G
E
K
D
L
R
L
L
E
K
L
G
D
G
S
F
G
V
V
R
R
G
E
W
D
A
P
S
---
G
K
T
V
S
--
V
-
A
V
K
C
L
K
P
-
D
V
L
S
Q
P
E
A
M
D
D
F
I
R
E
V
N
A
M
H
S
L
-
D
H
R
N
L
I
R
L
Y
G
V
-
V
-
L
-
T
-
P
---
P
-
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
H
Q
------
G
-
H
F
L
-
L
G
-
T
L
S
R
Y
-
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
G
L
M
R
A
L
P
Q
N
D
D
H
Y
V
M
---
R
K
V
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
---------
W
I
G
L
N
G
---
S
Q
----
I
L
H
K
I
D
--
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
--
V
A
L
R
D
F
L
L
E
A
Q
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
81.25
100%
-120
- C5 -
-
3EQR
9.4
-
ACK1_HUMAN
A:
[1-276]
---------------------------------------------------------------------------------------------------------------------
L
T
C
L
----
I
G
E
K
D
L
R
L
L
E
K
L
G
D
G
S
F
G
V
V
R
R
G
E
W
D
A
P
S
---
G
K
T
V
S
--
V
-
A
V
K
C
L
K
-------
P
E
A
M
D
D
F
I
R
E
V
N
A
M
H
S
L
-
D
H
R
N
L
I
R
L
Y
G
V
-
V
-
L
-
T
-
P
---
P
-
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
H
Q
------
G
-
H
F
L
-
L
G
-
T
L
S
R
Y
-
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
G
L
M
R
A
L
P
Q
N
D
D
H
Y
V
M
Q
E
H
R
K
V
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
---------
W
I
G
L
N
G
---
S
Q
----
I
L
H
K
I
D
--
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
--
V
A
L
R
D
F
L
L
E
A
Q
P
T
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Blastp_CBE
80.47
99%
-109
- C5 -
-
4EWH
8.3
-
ACK1_HUMAN
A:
[1-275]
---------------------------------------------------------------------------------------------------------------------
L
T
C
L
----
I
G
E
K
D
L
R
L
L
E
K
L
G
D
G
S
F
G
V
V
R
R
G
E
W
D
A
P
S
---
G
K
T
V
S
--
V
-
A
V
K
C
L
K
P
-
D
V
L
S
Q
P
E
A
M
D
D
F
I
R
E
V
N
A
M
H
S
L
-
D
H
R
N
L
I
R
L
Y
G
V
-
V
-
L
-
T
-
P
---
P
-
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
H
Q
------
G
-
H
F
L
-
L
G
-
T
L
S
R
Y
-
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
G
L
M
R
A
L
P
Q
N
D
D
H
Y
V
M
Q
E
H
R
K
V
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
---------
W
I
G
L
N
G
---
S
Q
----
I
L
H
K
I
D
--
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
--
V
A
L
R
D
F
L
L
E
A
Q
P
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
80.05
99%
-113
- C5 -
-
4EWH
8.5
-
ACK1_HUMAN
B:
[1-274]
---------------------------------------------------------------------------------------------------------------------
L
T
C
L
----
I
G
E
K
D
L
R
L
L
E
K
L
G
D
G
S
F
G
V
V
R
R
G
E
W
D
A
P
S
---
G
K
T
V
S
--
V
-
A
V
K
C
L
K
P
-
D
V
L
S
Q
P
E
A
M
D
D
F
I
R
E
V
N
A
M
H
S
L
-
D
H
R
N
L
I
R
L
Y
G
V
-
V
-
L
-
T
-
P
---
P
-
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
H
Q
------
G
-
H
F
L
-
L
G
-
T
L
S
R
Y
-
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
G
L
M
R
A
L
P
Q
N
D
D
H
Y
V
M
Q
E
H
R
K
V
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
---------
W
I
G
L
N
G
---
S
Q
----
I
L
H
K
I
D
--
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
--
V
A
L
R
D
F
L
L
E
A
Q
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
538
HHSearch
79.87
100%
-111
- C5 -
-
4EWH
8.3
-
ACK1_HUMAN
A:
[3-274]
-----------------------------------------------------------------------------------------------------------------------
C
L
----
I
G
E
K
D
L
R
L
L
E
K
L
G
D
G
S
F
G
V
V
R
R
G
E
W
D
A
P
S
---
G
K
T
V
S
--
V
-
A
V
K
C
L
K
P
-
D
V
L
S
Q
P
E
A
M
D
D
F
I
R
E
V
N
A
M
H
S
L
-
D
H
R
N
L
I
R
L
Y
G
V
-
V
-
L
-
T
-
P
---
P
-
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
H
Q
------
G
-
H
F
L
-
L
G
-
T
L
S
R
Y
-
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
G
L
M
R
A
L
P
Q
N
D
D
H
Y
V
M
Q
E
H
R
K
V
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
---------
W
I
G
L
N
G
---
S
Q
----
I
L
H
K
I
D
--
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
--
V
A
L
R
D
F
L
L
E
A
Q
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Blastp_CBE
79.52
100%
-118
- C5 -
-
3EQP
10.1
-
ACK1_HUMAN
A:
[1-274]
---------------------------------------------------------------------------------------------------------------------
L
T
C
L
----
I
G
E
K
D
L
R
L
L
E
K
L
G
D
G
S
F
G
V
V
R
R
G
E
W
D
A
P
S
---
G
K
T
V
S
--
V
-
A
V
K
C
L
-------
Q
P
E
A
M
D
D
F
I
R
E
V
N
A
M
H
S
L
-
D
H
R
N
L
I
R
L
Y
G
V
-
V
-
L
-
T
-
P
---
P
-
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
H
Q
------
G
-
H
F
L
-
L
G
-
T
L
S
R
Y
-
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
G
L
M
R
A
L
P
Q
N
D
D
H
Y
V
M
Q
E
H
R
K
V
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
---------
W
I
G
L
N
G
---
S
Q
----
I
L
H
K
I
D
--
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
--
V
A
L
R
D
F
L
L
E
A
Q
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Blastp_CBE
79.38
99%
-125
- C5 -
-
1U54
4.3
-
ACK1_HUMAN
A:
[9-284]
-------------------------------------------------------------------------------------------------------------------
Q
S
L
T
C
L
----
I
G
E
K
D
L
R
L
L
E
K
L
G
D
---
G
V
V
R
R
G
E
W
D
A
P
S
---
G
K
T
V
S
--
V
-
A
V
K
C
L
----------
A
M
D
D
F
I
R
E
V
N
A
M
H
S
L
-
D
H
R
N
L
I
R
L
Y
G
V
-
V
-
L
-
T
-
P
---
P
-
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
H
Q
------
G
-
H
F
L
-
L
G
-
T
L
S
R
Y
-
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
G
L
M
R
A
L
P
Q
N
D
D
H
Y
V
M
Q
E
H
R
-
V
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
---------
W
I
G
L
N
G
---
S
Q
----
I
L
H
K
I
D
--
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
--
V
A
L
R
D
F
L
L
E
A
Q
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
79.27
100%
-116
- C5 -
-
4ID7
7.5
-
ACK1_HUMAN
A:
[1-273]
---------------------------------------------------------------------------------------------------------------------
L
T
C
L
----
I
G
E
K
D
L
R
L
L
E
K
L
G
D
G
S
F
G
V
V
R
R
G
E
W
D
A
P
S
---
G
K
T
V
S
--
V
-
A
V
K
C
L
K
P
------
P
E
A
M
D
D
F
I
R
E
V
N
A
M
H
S
L
-
D
H
R
N
L
I
R
L
Y
G
V
-
V
-
L
-
T
-
P
---
P
-
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
H
Q
------
G
-
H
F
L
-
L
G
-
T
L
S
R
Y
-
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
G
L
M
R
A
L
P
Q
N
D
D
H
Y
V
M
Q
E
H
R
K
V
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
---------
W
I
G
L
N
G
---
S
Q
----
I
L
H
K
I
D
--
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
--
V
A
L
R
D
F
L
L
E
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
78.99
100%
-115
- C5 -
-
3EQP
10.1
-
ACK1_HUMAN
B:
[1-276]
---------------------------------------------------------------------------------------------------------------------
L
T
C
L
----
I
G
E
K
D
L
R
L
L
E
K
L
G
D
G
S
F
G
V
V
R
R
G
E
W
D
A
P
S
---
G
K
T
V
S
--
V
-
A
V
K
C
L
-------
Q
P
E
A
M
D
D
F
I
R
E
V
N
A
M
H
S
L
-
D
H
R
N
L
I
R
L
Y
G
V
-
V
-
L
-
T
-
P
---
P
-
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
H
Q
------
G
-
H
F
L
-
L
G
-
T
L
S
R
Y
-
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
G
L
M
R
A
L
P
Q
N
D
D
H
Y
V
M
Q
E
H
R
K
V
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
---------
W
I
G
L
N
G
---
S
Q
----
I
L
H
K
I
D
--
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
--
V
A
L
R
D
F
L
L
E
A
Q
P
T
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
539
HHSearch
78.15
100%
-124
- C5 -
-
4HZR
-
-
ACK1_HUMAN
B:
[7-276]
-----------------------------------------------------------------------------------------------------------------------
C
L
----
I
G
E
K
D
L
R
L
L
E
K
L
-----
G
V
V
R
R
G
E
W
D
A
P
S
---
G
K
T
V
S
--
V
-
A
V
K
C
----------
E
A
M
D
D
F
I
R
E
V
N
A
M
H
S
L
-
D
H
R
N
L
I
R
L
Y
G
V
-
V
-
L
-
T
-
P
---
P
-
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
H
Q
------
G
-
H
F
L
-
L
G
-
T
L
S
R
Y
-
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
G
L
M
R
A
L
P
Q
N
D
D
H
Y
V
M
Q
E
H
R
K
V
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
---------
W
I
G
L
N
G
---
S
Q
----
I
L
H
K
I
D
--
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
--
V
A
L
R
D
F
L
L
E
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Blastp_CBE
78.08
100%
-120
- C5 -
-
4HZR
-
-
ACK1_HUMAN
B:
[6-277]
----------------------------------------------------------------------------------------------------------------------
T
C
L
----
I
G
E
K
D
L
R
L
L
E
K
L
-----
G
V
V
R
R
G
E
W
D
A
P
S
---
G
K
T
V
S
--
V
-
A
V
K
C
----------
E
A
M
D
D
F
I
R
E
V
N
A
M
H
S
L
-
D
H
R
N
L
I
R
L
Y
G
V
-
V
-
L
-
T
-
P
---
P
-
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
H
Q
------
G
-
H
F
L
-
L
G
-
T
L
S
R
Y
-
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
G
L
M
R
A
L
P
Q
N
D
D
H
Y
V
M
Q
E
H
R
K
V
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
---------
W
I
G
L
N
G
---
S
Q
----
I
L
H
K
I
D
--
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
--
V
A
L
R
D
F
L
L
E
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
77.90
100%
-123
- C5 -
-
4HZR
-
-
ACK1_HUMAN
A:
[5-277]
---------------------------------------------------------------------------------------------------------------------
L
T
C
L
----
I
G
E
K
D
L
R
L
L
E
K
L
G
D
---
G
V
V
R
R
G
E
W
D
A
P
S
---
G
K
T
V
S
--
V
-
A
V
K
C
L
----------
A
M
D
D
F
I
R
E
V
N
A
M
H
S
L
-
D
H
R
N
L
I
R
L
Y
G
V
-
V
-
L
-
T
-
P
---
P
-
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
H
Q
------
G
-
H
F
L
-
L
G
-
T
L
S
R
Y
-
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
G
L
M
R
A
L
P
Q
N
D
D
H
Y
V
M
Q
E
H
R
K
V
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
---------
W
I
G
L
N
G
---
S
Q
----
I
L
H
K
I
D
--
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
--
V
A
L
R
D
F
L
L
E
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
77.45
99%
-122
- C5 -
-
1U4D
4.7
-
ACK1_HUMAN
A:
[11-283]
---------------------------------------------------------------------------------------------------------------------
L
T
C
L
----
I
G
E
K
D
L
R
L
L
E
K
L
G
D
G
S
F
G
V
V
R
R
G
E
W
D
A
P
S
---
G
K
T
V
S
--
V
-
A
V
K
C
---------
P
E
A
M
D
D
F
I
R
E
V
N
A
M
H
S
L
-
D
H
R
N
L
I
R
L
Y
G
V
-
V
-
L
-
T
-
P
---
P
-
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
H
Q
------
G
-
H
F
L
-
L
G
-
T
L
S
R
Y
-
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
G
L
M
R
A
L
P
Q
--
D
H
Y
V
M
-----
V
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
---------
W
I
G
L
N
G
---
S
Q
----
I
L
H
K
I
D
--
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
--
V
A
L
R
D
F
L
L
E
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Blastp_CBE
77.41
99%
-120
- C5 -
-
1U4D
4.6
-
ACK1_HUMAN
B:
[11-284]
---------------------------------------------------------------------------------------------------------------------
L
T
C
L
----
I
G
E
K
D
L
R
L
L
E
K
L
G
D
G
S
F
G
V
V
R
R
G
E
W
D
A
P
S
---
G
K
T
V
S
--
V
-
A
V
K
C
L
----------
A
M
D
D
F
I
R
E
V
N
A
M
H
S
L
-
D
H
R
N
L
I
R
L
Y
G
V
-
V
-
L
-
T
-
P
---
P
-
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
H
Q
----------
L
-
L
G
-
T
L
S
R
Y
-
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
G
L
M
R
A
L
P
Q
N
D
D
H
Y
V
M
Q
E
H
R
K
V
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
---------
W
I
G
L
N
G
---
S
Q
----
I
L
H
K
I
D
--
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
--
V
A
L
R
D
F
L
L
E
A
Q
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
77.28
99%
-127
- C5 -
-
1U54
4.2
-
ACK1_HUMAN
B:
[11-282]
---------------------------------------------------------------------------------------------------------------------
L
T
C
L
----
I
G
E
K
D
L
R
L
L
E
K
L
G
D
---
G
V
V
R
R
G
E
W
D
A
P
S
---
G
K
T
V
S
--
V
-
A
V
K
C
L
---------
E
A
M
D
D
F
I
R
E
V
N
A
M
H
S
L
-
D
H
R
N
L
I
R
L
Y
G
V
-
V
-
L
-
T
-
P
---
P
-
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
H
Q
------
G
-
H
F
L
-
L
G
-
T
L
S
R
Y
-
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
G
L
M
R
A
L
P
Q
N
D
D
H
Y
V
M
Q
E
H
R
K
V
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
---------
W
I
G
L
N
G
---
S
Q
----
I
L
H
K
I
D
--
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
--
V
A
L
R
D
F
L
L
E
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
76.87
99%
-130
- C5 -
-
1U46
-
-
ACK1_HUMAN
A:
[11-283]
---------------------------------------------------------------------------------------------------------------------
L
T
C
L
----
I
G
E
K
D
L
R
L
L
E
K
L
G
----
G
V
V
R
R
G
E
W
D
A
P
S
---
G
K
T
V
S
--
V
-
A
V
K
C
---------
P
E
A
M
D
D
F
I
R
E
V
N
A
M
H
S
L
-
D
H
R
N
L
I
R
L
Y
G
V
-
V
-
L
-
T
-
P
---
P
-
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
H
Q
------
G
-
H
F
L
-
L
G
-
T
L
S
R
Y
-
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
G
L
M
R
A
L
P
Q
-
D
D
H
Y
V
M
-----
V
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
---------
W
I
G
L
N
G
---
S
Q
----
I
L
H
K
I
D
--
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
--
V
A
L
R
D
F
L
L
E
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
74.63
100%
-121
- C5 -
-
5ZXB
11.5
-
ACK1_HUMAN
A:
[1-273]
---------------------------------------------------------------------------------------------------------------------
L
T
C
L
----
I
G
E
K
D
L
R
L
L
E
K
L
G
D
---
G
V
V
R
R
G
E
W
D
A
P
S
---
G
K
T
V
S
--
V
-
A
V
K
C
L
----------
A
M
D
D
F
I
R
E
V
N
A
M
H
S
L
-
D
H
R
N
L
I
R
L
Y
G
V
-
V
-
L
-
T
-
P
---
P
-
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
H
Q
------
G
-
H
F
L
-
L
G
-
T
L
S
R
Y
-
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
---------------------
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
---------
W
I
G
L
N
G
---
S
Q
----
I
L
H
K
I
D
--
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
--
V
A
L
R
D
F
L
L
E
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Blastp_CBE
74.24
100%
-123
- C5 -
-
5ZXB
12.6
-
ACK1_HUMAN
B:
[1-273]
---------------------------------------------------------------------------------------------------------------------
L
T
C
L
----
I
G
E
K
D
L
R
L
L
E
K
L
G
D
----
V
V
R
R
G
E
W
D
A
P
S
---
G
K
T
V
S
--
V
-
A
V
K
C
L
-------
Q
P
E
A
M
D
D
F
I
R
E
V
N
A
M
H
S
L
-
D
H
R
N
L
I
R
L
Y
G
V
-
V
-
L
-
T
-
P
---
P
-
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
H
Q
------
G
-
H
F
--
L
G
-
T
L
S
R
Y
-
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
---------------------
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
---------
W
I
G
L
N
G
---
S
Q
----
I
L
H
K
I
D
--
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
--
V
A
L
R
D
F
L
L
E
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Blastp_CBE
67.78
39%
-112
- C5 -
-
4RIX
4.7
-
D:
[14-290]
---------------------------------------------------------------------------------------------------------
P
L
T
P
S
G
E
A
P
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
-
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
161
Blastp_CBE
67.44
39%
-130
- C5 -
-
6P8Q
6.1
-
?
A:
[4-272]
-----------------------------------------------------------------------------------------------------------------
P
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
-------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Blastp_CBE
67.28
39%
-112
- C5 -
-
4RIW
5.2
-
D:
[14-290]
---------------------------------------------------------------------------------------------------------
P
L
T
P
S
G
E
A
P
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
-
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Blastp_CBE
67.26
39%
-118
- C5 -
-
4RIX
4.0
-
EGFR_HUMAN
B:
[14-290]
---------------------------------------------------------------------------------------------------------
P
L
T
P
S
G
E
A
P
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
-
H
A
----
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Blastp_CBE
67.22
39%
-115
- C5 -
-
4RIW
4.7
-
EGFR_HUMAN
B:
[14-290]
---------------------------------------------------------------------------------------------------------
P
L
T
P
S
G
E
A
P
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
-
H
A
----
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Blastp_CBE
67.09
40%
-113
- C5 -
-
3W32
5.8
-
A:
[9-275]
-------------------------------------------------------------------------------------------------------------------
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
-
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
137
Blastp_CBE
66.93
39%
-115
- C5 -
-
5X2A
4.3
-
EGFR_HUMAN
B:
[9-277]
------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
-
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
166
Blastp_CBE
66.78
39%
-132
- C5 -
-
6P1D
5.9
-
?
D:
[6-272]
-------------------------------------------------------------------------------------------------------------------
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
--------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
270
Blastp_CBE
66.76
38%
-126
- C5 -
-
3W2Q
2.0
-
A:
[7-290]
----------------------------------------------------------------------------------------------------------------
A
P
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
G
A
E
E
K
E
Y
-
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
268
Blastp_CBE
66.71
39%
-116
- C5 -
-
6S89
3.3
-
?
A:
[8-289]
---------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
M
Q
L
M
P
F
G
S
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
A
A
A
E
Y
-
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
142
Blastp_CBE
66.54
39%
-131
- C5 -
-
4ZSE
5.4
-
EGFR_HUMAN
C:
[9-276]
------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
--------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
267
Blastp_CBE
66.52
39%
-119
- C5 -
-
6S8A
6.1
-
?
A:
[8-287]
---------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
M
Q
L
M
P
F
G
S
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
A
A
A
E
Y
-
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
Blastp_CBE
66.51
40%
-127
- C5 -
-
2R4B
8.2
-
ERBB4_HUMAN
A:
[19-292]
---------------------------------------------------------------------------------------------------------
P
L
T
P
S
G
T
A
P
N
Q
A
Q
L
R
I
----
L
K
E
T
E
L
K
R
V
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
-
V
P
E
---
G
E
T
V
K
--
I
-
P
V
A
I
K
I
L
-
N
------
A
N
V
E
F
M
D
E
A
L
I
M
A
S
M
-
D
H
P
H
L
V
R
L
L
G
V
-
C
-
L
-
S
-
P
---
T
-
I
Q
L
V
T
Q
L
M
P
H
G
C
L
L
E
Y
V
H
E
H
K
------
D
-
N
I
G
-
S
Q
-
L
L
L
N
W
-
C
V
Q
I
A
K
G
M
M
Y
L
E
E
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
E
G
D
E
K
E
Y
-
N
A
D
G
G
K
M
P
I
K
W
M
A
L
E
C
I
H
Y
R
K
F
T
H
Q
S
D
V
W
S
Y
G
V
T
I
W
E
L
M
T
F
G
G
K
P
---------
Y
D
G
I
P
T
---
R
E
----
I
P
D
L
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
--
K
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Blastp_CBE
66.49
39%
-115
- C5 -
-
4RIY
4.2
-
EGFR_HUMAN
B:
[14-290]
---------------------------------------------------------------------------------------------------------
P
L
T
P
S
G
E
A
P
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
-
H
A
----
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
Blastp_CBE
66.47
40%
-122
- C5 -
-
5CNN
6.2
-
B:
[8-275]
------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
Q
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
------------
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Blastp_CBE
66.47
39%
-105
- C5 -
-
4RIY
4.7
-
D:
[14-290]
---------------------------------------------------------------------------------------------------------
P
L
T
P
S
G
E
A
P
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
-
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
144
Blastp_CBE
66.40
39%
-127
- C5 -
-
4ZSE
5.5
-
EGFR_HUMAN
A:
[8-276]
-----------------------------------------------------------------------------------------------------------------
P
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
167
Blastp_CBE
66.22
39%
-134
- C5 -
-
6P1D
5.7
-
?
C:
[7-272]
--------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
--------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
168
Blastp_CBE
66.16
39%
-127
- C5 -
-
6P1D
5.8
-
?
B:
[7-272]
--------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
-------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
139
Blastp_CBE
66.16
39%
-127
- C5 -
-
5D41
6.0
-
B:
[10-276]
-------------------------------------------------------------------------------------------------------------------
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
160
Blastp_CBE
66.02
39%
-122
- C5 -
-
6P8Q
4.6
-
?
B:
[3-272]
----------------------------------------------------------------------------------------------------------------
A
P
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
-----------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
191
Blastp_CBE
65.82
39%
-133
- C5 -
-
5CAN
6.0
-
A:
[3-281]
--------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
---
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
---------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
Blastp_CBE
65.82
40%
-129
- C5 -
-
2R4B
7.8
-
B:
[19-292]
---------------------------------------------------------------------------------------------------------
P
L
T
P
S
G
T
A
P
N
Q
A
Q
L
R
I
----
L
K
E
T
E
L
K
R
V
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
-
V
P
E
---
G
E
T
V
K
--
I
-
P
V
A
I
K
I
L
--------
A
N
V
E
F
M
D
E
A
L
I
M
A
S
M
-
D
H
P
H
L
V
R
L
L
G
V
-
C
-
L
-
S
-
P
---
T
-
I
Q
L
V
T
Q
L
M
P
H
G
C
L
L
E
Y
V
H
E
H
K
------
D
-
N
I
G
-
S
Q
-
L
L
L
N
W
-
C
V
Q
I
A
K
G
M
M
Y
L
E
E
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
E
G
D
E
K
E
Y
-
N
A
D
G
G
K
M
P
I
K
W
M
A
L
E
C
I
H
Y
R
K
F
T
H
Q
S
D
V
W
S
Y
G
V
T
I
W
E
L
M
T
F
G
G
K
P
---------
Y
D
G
I
P
T
---
R
E
----
I
P
D
L
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
--
K
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
188
Blastp_CBE
65.70
39%
-133
- C5 -
-
5CAQ
5.8
-
A:
[4-279]
---------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
---
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
---------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
133
Blastp_CBE
65.70
39%
-122
- C5 -
-
5X2C
2.7
-
B:
[10-276]
-------------------------------------------------------------------------------------------------------------------
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
------------
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
177
Blastp_CBE
65.68
39%
-122
- C5 -
-
5HIB
5.8
-
A:
[3-278]
--------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
-----
E
Y
-
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
Blastp_CBE
65.61
39%
-125
- C5 -
-
5EM8
5.7
-
A:
[3-289]
--------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
----
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
--
K
E
Y
-
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
181
Blastp_CBE
65.57
39%
-136
- C5 -
-
5EM7
5.6
-
A:
[3-281]
--------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
----
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
---------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
Blastp_CBE
65.57
39%
-123
- C5 -
-
4I24
6.5
-
B:
[7-274]
------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
------------
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
169
Blastp_CBE
65.54
39%
-128
- C5 -
-
6P1D
5.3
-
?
A:
[5-272]
------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
--------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
198
Blastp_CBE
65.51
39%
-134
- C5 -
-
4RJ6
5.4
-
A:
[4-281]
---------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
-----
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
---------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
201
Blastp_CBE
65.50
40%
-123
- C5 -
-
3BCE
2.4
-
C:
[2-269]
---------------------------------------------------------------------------------------------------------------
T
A
P
N
Q
A
Q
L
R
I
----
L
K
E
T
E
L
K
R
V
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
-
V
P
E
---
G
E
T
V
K
--
I
-
P
V
A
I
K
I
L
-
N
E
T
T
G
P
K
A
N
V
E
F
M
D
E
A
L
I
M
A
S
M
-
D
H
P
H
L
V
R
L
L
G
V
-
C
-
L
-
S
-
P
---
T
-
I
Q
L
V
T
Q
L
M
P
H
G
C
L
L
E
Y
V
H
E
H
K
------
D
-
N
I
G
-
S
Q
-
L
L
L
N
W
-
C
V
Q
I
A
K
G
M
M
Y
L
E
E
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
E
-
D
E
K
E
Y
-
N
A
D
-
G
K
M
P
I
K
W
M
A
L
E
C
I
H
Y
R
K
F
T
H
Q
S
D
V
W
S
Y
G
V
T
I
W
E
L
M
T
F
G
G
K
P
---------
Y
D
G
I
P
T
---
R
E
----
I
P
D
L
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
--
K
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
143
Blastp_CBE
65.47
39%
-124
- C5 -
-
4ZSE
5.0
-
EGFR_HUMAN
B:
[7-276]
----------------------------------------------------------------------------------------------------------------
A
P
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
Blastp_CBE
65.47
39%
-115
- C5 -
-
5UGB
5.2
-
A:
[2-289]
-------------------------------------------------------------------------------------------------------------
S
G
E
A
P
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
---
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
-
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
Blastp_CBE
65.46
40%
-117
- C5 -
-
6JZ0
8.3
-
?
A:
[1-284]
--------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
-
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
-
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
112
Blastp_CBE
65.41
39%
-124
- C5 -
-
2ITN
5.2
-
A:
[1-283]
--------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
S
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
----------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
149
Blastp_CBE
65.22
39%
-120
- C5 -
-
2ITV
5.2
-
A:
[1-284]
--------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
G
A
E
E
----------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
Blastp_CBE
65.18
39%
-125
- C5 -
-
2EB3
6.0
-
A:
[8-293]
--------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
-
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
---------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
192
Blastp_CBE
65.10
39%
-131
- C5 -
-
5CAL
5.5
-
A:
[4-279]
---------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
---
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
----------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
210
Blastp_CBE
65.04
38%
-119
- C5 -
-
5UG9
5.8
-
A:
[9-274]
--------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
----
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
G
A
E
E
K
E
Y
-
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
Blastp_CBE
65.04
40%
-111
- C5 -
-
2GS6
4.3
-
A:
[1-288]
-----------------------------------------------------------------------------------------------------------
G
A
M
G
E
A
P
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
----
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
-
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
179
Blastp_CBE
64.98
39%
-131
- C5 -
-
5HCY
6.7
-
A:
[3-281]
--------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
---
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
--------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
180
Blastp_CBE
64.95
39%
-131
- C5 -
-
5HCX
6.3
-
A:
[3-282]
--------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
----
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
---------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
216
Blastp_CBE
64.92
38%
-114
- C5 -
-
5HG5
6.4
-
A:
[7-274]
------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
G
A
E
E
K
E
Y
-
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
Blastp_CBE
64.92
39%
-119
- C5 -
-
5GNK
7.4
-
A:
[6-276]
---------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
-------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
Blastp_CBE
64.90
40%
-119
- C5 -
-
5CNN
5.7
-
EGFR_HUMAN
A:
[7-275]
-----------------------------------------------------------------------------------------------------------------
P
N
Q
A
L
L
R
Q
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
E
A
---
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
--------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
138
Blastp_CBE
64.88
39%
-134
- C5 -
-
5X2A
3.9
-
EGFR_HUMAN
A:
[9-278]
------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
--------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
437
Blastp_CBE
64.87
37%
-129
- C5 -
-
4H1J
11.0
-
A:
[21-276]
-----------------------------------------------------------------------------------------------------------------------------
I
A
R
E
D
V
V
L
N
R
I
L
G
E
G
F
F
G
E
V
Y
E
G
V
Y
T
N
H
K
---
G
E
K
I
N
--
V
-
A
V
K
T
C
K
K
-
D
C
--
T
L
D
N
K
E
K
F
M
S
E
A
V
I
M
K
N
L
-
D
H
P
H
I
V
K
L
I
G
I
-
I
-
E
-
E
-
E
---
P
-
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
E
R
N
K
------
N
-
S
L
K
-
V
L
-
T
L
V
L
Y
-
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
A
S
P
E
C
V
K
L
G
D
F
G
L
S
R
-----------
A
S
V
T
R
L
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
---------
F
F
W
L
E
N
---
K
D
----
V
I
G
V
L
E
--
K
-
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
--
T
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
213
Blastp_CBE
64.84
38%
-115
- C5 -
-
5HG9
6.0
-
A:
[9-274]
--------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
----
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
G
A
E
E
K
E
Y
-
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
208
Blastp_CBE
64.84
38%
-118
- C5 -
-
5UGC
5.9
-
A:
[9-274]
--------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
----
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
G
A
E
E
K
E
Y
-
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
196
Blastp_CBE
64.82
39%
-133
- C5 -
-
4RJ8
4.6
-
A:
[4-280]
---------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-----
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
---------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
Blastp_CBE
64.80
39%
-124
- C5 -
-
3GT8
4.8
-
EGFR_HUMAN
A:
[8-275]
------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
----------------
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
Blastp_CBE
64.80
39%
-123
- C5 -
-
5CNO
6.5
-
EGFR_HUMAN
B:
[6-275]
----------------------------------------------------------------------------------------------------------------
A
P
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
E
----
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
Blastp_CBE
64.79
39%
-126
- C5 -
-
5CNO
6.8
-
EGFR_HUMAN
A:
[8-275]
------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
E
-----
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
------------
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
214
Blastp_CBE
64.73
38%
-113
- C5 -
-
5HG8
6.0
-
A:
[7-274]
------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
G
A
E
E
K
E
Y
-
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
117
Blastp_CBE
64.69
39%
-122
- C5 -
-
5J9Z
5.9
-
A:
[1-291]
--------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
----------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
225
Blastp_CBE
64.62
39%
-129
- C5 -
-
6S9B
6.2
-
?
A:
[1-288]
---------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
----
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
-------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
190
Blastp_CBE
64.57
39%
-134
- C5 -
-
5CAO
6.0
-
A:
[4-278]
---------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
----
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
-----------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
205
Blastp_CBE
64.55
39%
-125
- C5 -
-
6S9D
5.5
-
?
A:
[3-285]
--------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
--
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
------------
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
178
Blastp_CBE
64.53
39%
-127
- C5 -
-
5HCZ
5.8
-
A:
[3-281]
--------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
----
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
---------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
206
Blastp_CBE
64.52
39%
-126
- C5 -
-
6S9C
5.0
-
?
A:
[3-285]
--------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
--
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
-------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
219
Blastp_CBE
64.50
38%
-151
- C5 -
-
4KAB
3.8
-
FAK1_HUMAN
A:
[10-266]
-----------------------------------------------------------------------------------------------------------------------------
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
P
-----
P
A
L
A
--
V
-
A
I
K
T
C
K
N
---
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
-
I
-
T
-
E
-
N
---
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
------
Y
-
S
L
D
-
L
A
-
S
L
I
L
Y
-
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
--------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
---------
F
Q
G
V
K
N
---
N
D
----
V
I
G
R
I
E
--
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
--
T
E
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
197
Blastp_CBE
64.45
39%
-133
- C5 -
-
4RJ7
6.9
-
A:
[4-282]
---------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
------
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
---------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
140
Blastp_CBE
64.42
39%
-122
- C5 -
-
5D41
5.9
-
EGFR_HUMAN
A:
[7-276]
----------------------------------------------------------------------------------------------------------------
A
P
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
------------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
211
Blastp_CBE
64.41
38%
-120
- C5 -
-
5UG8
6.2
-
A:
[9-274]
--------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
----
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
G
A
E
E
K
E
Y
-
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
64.40
39%
-120
- C5 -
-
4LQM
4.3
-
A:
[6-284]
---------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
----
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
G
A
E
E
--------
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
141
Blastp_CBE
64.32
39%
-122
- C5 -
-
4ZSE
4.9
-
D:
[10-280]
-------------------------------------------------------------------------------------------------------------------
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
E
--
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
-------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
176
Blastp_CBE
64.14
39%
-128
- C5 -
-
5HIC
6.5
-
A:
[4-279]
---------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
---
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
---------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
374
Blastp_CBE
64.08
37%
-140
- C5 -
-
3H3C
6.5
-
A:
[5-260]
-----------------------------------------------------------------------------------------------------------------------------
I
A
R
E
D
V
V
L
N
R
I
L
G
E
G
F
F
G
E
V
Y
E
G
V
Y
T
N
H
K
---
G
E
K
I
N
--
V
-
A
V
K
T
C
K
K
-
D
C
--
T
L
D
N
K
E
K
F
M
S
E
A
V
I
M
K
N
L
-
D
H
P
H
I
V
K
L
I
G
I
-
I
-
E
-
E
-
E
---
P
-
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
E
R
N
K
------
N
-
S
L
K
-
V
L
-
T
L
V
L
Y
-
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
A
S
P
E
C
V
K
L
G
D
F
G
L
----------------
T
R
L
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
---------
F
F
W
L
E
N
---
K
D
----
V
I
G
V
L
E
--
K
-
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
--
T
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
215
Blastp_CBE
63.99
38%
-114
- C5 -
-
5HG7
5.9
-
A:
[9-274]
--------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
---
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
G
A
E
E
K
E
Y
-
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
287
Blastp_CBE
63.94
39%
-148
- C5 -
-
2J0M
7.6
-
?
B:
[18-263]
----------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
P
E
---
N
P
A
L
A
--
V
-
A
I
K
T
C
K
N
---
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
-
I
-
T
-
E
-
N
---
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
------
Y
-
S
L
D
-
L
A
-
S
L
I
L
Y
-
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
---------
F
Q
G
V
K
N
---
N
D
----
V
I
G
R
I
E
--
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
--
T
E
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
162
Blastp_CBE
63.91
39%
-131
- C5 -
-
6P1L
5.5
-
?
D:
[7-273]
--------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
------------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
170
Blastp_CBE
63.90
39%
-118
- C5 -
-
5JEB
6.8
-
A:
[14-282]
-----------------------------------------------------------------------------------------------------------------
P
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
--
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
-
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
Blastp_CBE
63.90
39%
-122
- C5 -
-
3GT8
5.4
-
EGFR_HUMAN
C:
[7-275]
-----------------------------------------------------------------------------------------------------------------
P
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
--------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
Blastp_CBE
63.87
39%
-127
- C5 -
-
3GT8
5.9
-
EGFR_HUMAN
B:
[9-275]
-------------------------------------------------------------------------------------------------------------------
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
----------------
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
Blastp_CBE
63.83
39%
-126
- C5 -
-
3GT8
4.4
-
D:
[9-275]
-------------------------------------------------------------------------------------------------------------------
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
----------------
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
164
Blastp_CBE
63.76
39%
-127
- C5 -
-
6P1L
4.9
-
?
B:
[7-272]
--------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
----------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
310
Blastp_CBE
63.71
39%
-136
- C5 -
-
2JKO
7.7
-
A:
[18-263]
----------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
P
E
---
N
P
A
M
A
--
V
-
A
I
K
T
C
K
N
---
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
-
I
-
T
-
E
-
N
---
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
------
F
-
S
L
D
-
L
A
-
S
L
I
L
Y
-
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
L
------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
---------
F
Q
G
V
K
N
---
N
D
----
V
I
G
R
I
E
--
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
--
T
E
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
150
Blastp_CBE
63.60
39%
-119
- C5 -
-
2ITU
5.1
-
A:
[1-282]
--------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
G
A
E
-----------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
377
Blastp_CBE
63.59
37%
-126
- C5 -
-
3FZR
5.7
-
A:
[5-260]
-----------------------------------------------------------------------------------------------------------------------------
I
A
R
E
D
V
V
L
N
R
I
L
G
E
G
F
F
G
E
V
Y
E
G
V
Y
T
N
H
K
---
G
E
K
I
N
--
V
-
A
V
K
T
C
K
K
-
D
C
--
T
L
D
N
K
E
K
F
M
S
E
A
V
I
M
K
N
L
-
D
H
P
H
I
V
K
L
I
G
I
-
I
-
E
-
E
-
E
---
P
-
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
E
R
N
K
------
N
-
S
L
K
-
V
L
-
T
L
V
L
Y
-
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
A
S
P
E
C
V
K
L
G
D
F
G
L
S
R
--------------
T
R
L
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
---------
F
F
W
L
E
N
---
K
D
----
V
I
G
V
L
E
--
K
-
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
--
T
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
Blastp_CBE
63.56
39%
-126
- C5 -
-
1XKK
9.5
-
A:
[32-309]
--------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
-------
V
K
--
I
-
P
V
A
I
K
E
L
-
R
E
----
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
---------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
436
Blastp_CBE
63.47
37%
-137
- C5 -
-
4H1M
9.7
-
A:
[21-276]
-----------------------------------------------------------------------------------------------------------------------------
I
A
R
E
D
V
V
L
N
R
I
L
G
E
G
F
F
G
E
V
Y
E
G
V
Y
T
N
H
K
---
G
E
K
I
N
--
V
-
A
V
K
T
C
K
K
-
D
C
--
T
L
D
N
K
E
K
F
M
S
E
A
V
I
M
K
N
L
-
D
H
P
H
I
V
K
L
I
G
I
-
I
-
E
-
E
-
E
---
P
-
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
E
R
N
K
------
N
-
S
L
K
-
V
L
-
T
L
V
L
Y
-
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
A
S
P
E
C
V
K
L
G
D
F
G
L
S
-----------------
L
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
---------
F
F
W
L
E
N
---
K
D
----
V
I
G
V
L
E
--
K
-
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
--
T
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
121
Blastp_CBE
63.46
39%
-126
- C5 -
-
3UG2
2.1
-
A:
[9-294]
---------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
S
S
---
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
------
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
-
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
Blastp_CBE
63.38
40%
-115
- C5 -
-
2J5F
4.6
-
A:
[1-280]
--------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
---------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
375
Blastp_CBE
63.37
37%
-130
- C5 -
-
3FZT
10.3
-
A:
[5-260]
-----------------------------------------------------------------------------------------------------------------------------
I
A
R
E
D
V
V
L
N
R
I
L
G
E
G
F
F
G
E
V
Y
E
G
V
Y
T
N
H
K
---
G
E
K
I
N
--
V
-
A
V
K
T
C
K
K
-
D
C
--
T
L
D
N
K
E
K
F
M
S
E
A
V
I
M
K
N
L
-
D
H
P
H
I
V
K
L
I
G
I
-
I
-
E
-
E
-
E
---
P
-
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
E
R
N
K
------
N
-
S
L
K
-
V
L
-
T
L
V
L
Y
-
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
A
S
P
E
C
V
K
L
G
D
F
G
L
S
R
--------------
T
R
L
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
---------
F
F
W
L
E
N
---
K
D
----
V
I
G
V
L
E
--
K
-
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
--
T
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
292
Blastp_CBE
63.32
39%
-127
- C5 -
-
2RGP
8.1
-
A:
[1-280]
--------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
-------
V
K
--
I
-
P
V
A
I
K
E
L
-
R
-----
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
---------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
278
Blastp_CBE
63.32
39%
-138
- C5 -
-
3PXK
4.9
-
B:
[21-266]
----------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
P
E
---
N
P
A
L
A
--
V
-
A
I
K
T
C
K
N
---
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
-
I
-
T
-
E
-
N
---
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
------
Y
-
S
L
D
-
L
A
-
S
L
I
L
Y
-
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
---------
F
Q
G
V
K
N
---
N
D
----
V
I
G
R
I
E
--
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
--
T
E
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
279
Blastp_CBE
63.30
39%
-142
- C5 -
-
3PXK
4.5
-
FAK1_HUMAN
A:
[21-266]
----------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
P
E
---
N
P
A
L
A
--
V
-
A
I
K
T
C
K
N
---
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
-
I
-
T
-
E
-
N
---
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
------
Y
-
S
L
D
-
L
A
-
S
L
I
L
Y
-
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
-------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
---------
F
Q
G
V
K
N
---
N
D
----
V
I
G
R
I
E
--
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
--
T
E
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
308
Blastp_CBE
63.18
39%
-137
- C5 -
-
4C7T
7.2
-
A:
[18-263]
----------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
P
E
---
N
P
A
M
A
--
V
-
A
I
K
T
C
K
N
---
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
-
I
-
T
-
E
-
N
---
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
------
F
-
S
L
D
-
L
A
-
S
L
I
L
Y
-
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
--------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
---------
F
Q
G
V
K
N
---
N
D
----
V
I
G
R
I
E
--
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
--
T
E
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
Blastp_CBE
63.11
39%
-124
- C5 -
-
5XDL
5.5
-
A:
[5-290]
--------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
---
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
----------------
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
Blastp_CBE
63.06
40%
-114
- C5 -
-
2ITX
4.3
-
A:
[2-284]
---------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
----
E
K
E
Y
-
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
305
Blastp_CBE
62.98
39%
-134
- C5 -
-
4D4S
6.5
-
B:
[18-263]
----------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
P
E
---
N
P
A
M
A
--
V
-
A
I
K
T
C
K
N
---
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
-
I
-
T
-
E
-
N
---
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
------
F
-
S
L
D
-
L
A
-
S
L
I
L
Y
-
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
--------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
---------
F
Q
G
V
K
N
---
N
D
----
V
I
G
R
I
E
--
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
--
T
E
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
518
Blastp_CBE
62.78
39%
-136
- C5 -
-
2J0J
5.9
-
FAK1_CHICK
A:
[398-643]
----------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
P
E
---
N
P
A
M
A
--
V
-
A
I
K
T
C
K
N
---
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
-
I
-
T
-
E
-
N
---
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
------
F
-
S
L
D
-
L
A
-
S
L
I
L
Y
-
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
E
--
D
----------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
---------
F
Q
G
V
K
N
---
N
D
----
V
I
G
R
I
E
--
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
--
T
E
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
379
Blastp_CBE
62.67
37%
-124
- C5 -
-
3ET7
6.8
-
A:
[5-260]
-----------------------------------------------------------------------------------------------------------------------------
I
A
R
E
D
V
V
L
N
R
I
L
G
E
G
F
F
G
E
V
Y
E
G
V
Y
T
N
H
K
---
G
E
K
I
N
--
V
-
A
V
K
T
C
K
K
-
D
C
--
T
L
D
N
K
E
K
F
M
S
E
A
V
I
M
K
N
L
-
D
H
P
H
I
V
K
L
I
G
I
-
I
-
E
-
E
-
E
---
P
-
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
E
R
N
K
------
N
-
S
L
K
-
V
L
-
T
L
V
L
Y
-
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
A
S
P
E
C
V
K
L
G
D
F
G
L
S
R
--------------
T
R
L
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
---------
F
F
W
L
E
N
---
K
D
----
V
I
G
V
L
E
--
K
-
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
--
T
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
Blastp_CBE
62.60
40%
-129
- C5 -
-
3POZ
7.9
-
A:
[6-278]
-------------------------------------------------------------------------------------------------------------------
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
-------
V
K
--
I
-
P
V
A
I
K
E
L
--------
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
--------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
304
Blastp_CBE
62.52
39%
-138
- C5 -
-
4D4V
3.5
-
FAK1_CHICK
A:
[18-263]
----------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
P
E
---
N
P
A
M
A
--
V
-
A
I
K
T
C
K
N
---
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
-
I
-
T
-
E
-
N
---
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
------
F
-
S
L
D
-
L
A
-
S
L
I
L
Y
-
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
------------------
G
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
---------
F
Q
G
V
K
N
---
N
D
----
V
I
G
R
I
E
--
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
--
T
E
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
291
Blastp_CBE
62.52
39%
-129
- C5 -
-
3BEL
5.9
-
A:
[1-282]
--------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
-------
V
K
--
I
-
P
V
A
I
K
E
L
-------
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
---------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
155
Blastp_CBE
62.47
39%
-124
- C5 -
-
3LZB
5.9
-
EGFR_HUMAN
A:
[8-272]
---------------------------------------------------------------------------------------------------------------------
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
-----------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
297
Blastp_CBE
62.46
39%
-138
- C5 -
-
4D5H
5.0
-
FAK1_CHICK
A:
[18-263]
----------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
P
E
---
N
P
A
M
A
--
V
-
A
I
K
T
C
K
N
---
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
-
I
-
T
-
E
-
N
---
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
------
F
-
S
L
D
-
L
A
-
S
L
I
L
Y
-
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
-------------------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
---------
F
Q
G
V
K
N
---
N
D
----
V
I
G
R
I
E
--
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
--
T
E
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
298
Blastp_CBE
62.40
39%
-132
- C5 -
-
4D58
6.9
-
?
B:
[18-263]
----------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
P
E
---
N
P
A
M
A
--
V
-
A
I
K
T
C
K
N
---
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
-
I
-
T
-
E
-
N
---
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
------
F
-
S
L
D
-
L
A
-
S
L
I
L
Y
-
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
--------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
---------
F
Q
G
V
K
N
---
N
D
----
V
I
G
R
I
E
--
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
--
T
E
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
277
Blastp_CBE
62.40
39%
-124
- C5 -
-
4GU6
7.0
-
FAK1_HUMAN
A:
[21-266]
----------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
-----
N
P
A
L
A
--
V
-
A
I
K
T
C
K
N
---
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
-
I
-
T
-
E
-
N
---
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
------
Y
-
S
L
D
-
L
A
-
S
L
I
L
Y
-
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
--
E
D
S
T
Y
Y
K
A
S
K
G
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
---------
F
Q
G
V
K
N
---
N
D
----
V
I
G
R
I
E
--
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
--
T
E
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
378
Blastp_CBE
62.37
37%
-130
- C5 -
-
3FZP
4.9
-
A:
[5-260]
-----------------------------------------------------------------------------------------------------------------------------
I
A
R
E
D
V
V
L
N
R
I
L
G
E
G
F
F
G
E
V
Y
E
G
V
Y
T
N
H
K
---
G
E
K
I
N
--
V
-
A
V
K
T
C
K
K
-
D
C
--
T
L
D
N
K
E
K
F
M
S
E
A
V
I
M
K
N
L
-
D
H
P
H
I
V
K
L
I
G
I
-
I
-
E
-
E
-
E
---
P
-
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
E
R
N
K
------
N
-
S
L
K
-
V
L
-
T
L
V
L
Y
-
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
A
S
P
E
C
V
K
L
G
D
F
G
-----------------
T
R
L
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
---------
F
F
W
L
E
N
---
K
D
----
V
I
G
V
L
E
--
K
-
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
--
T
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
309
Blastp_CBE
62.21
39%
-137
- C5 -
-
4BRX
7.4
-
FAK1_CHICK
A:
[18-263]
----------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
P
E
---
N
P
A
M
A
--
V
-
A
I
K
T
C
K
N
---
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
-
I
-
T
-
E
-
N
---
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
------
F
-
S
L
D
-
L
A
-
S
L
I
L
Y
-
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
--------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
---------
F
Q
G
V
K
N
---
N
D
----
V
I
G
R
I
E
--
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
--
T
E
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
165
Blastp_CBE
62.10
39%
-132
- C5 -
-
6P1L
5.0
-
?
A:
[6-272]
-------------------------------------------------------------------------------------------------------------------
Q
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
E
A
--
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
------------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
264
Blastp_CBE
62.00
39%
-134
- C5 -
-
2IJM
4.2
-
FAK1_HUMAN
A:
[20-265]
----------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
P
E
---
N
P
A
L
A
--
V
-
A
I
K
T
C
K
N
---
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
-
I
-
T
-
E
-
N
---
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
------
Y
-
S
L
D
-
L
A
-
S
L
I
L
Y
-
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
-----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
---------
F
Q
G
V
K
N
---
N
D
----
V
I
G
R
I
E
--
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
--
T
E
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
407
Blastp_CBE
61.92
37%
-145
- C5 -
-
5TO8
7.3
-
A:
[10-265]
-----------------------------------------------------------------------------------------------------------------------------
I
A
R
E
D
V
V
L
N
R
I
L
G
E
G
F
F
G
E
V
Y
E
G
V
Y
T
N
H
K
---
G
E
K
I
N
--
V
-
A
V
K
T
C
K
K
-
D
C
--
T
--
N
K
E
K
F
M
S
E
A
V
I
M
K
N
L
-
D
H
P
H
I
V
K
L
I
G
I
-
I
-----
E
---
P
-
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
E
R
N
K
------
N
-
S
L
K
-
V
L
-
T
L
V
L
Y
-
S
L
Q
I
C
K
A
M
A
Y
L
E
S
--
C
V
H
R
D
I
A
V
R
N
I
L
V
A
S
P
E
C
V
K
L
G
D
F
G
L
S
R
------------------
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
---------
F
F
W
L
E
N
---
K
D
----
V
I
G
V
L
E
--
K
-
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
--
T
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
293
Blastp_CBE
61.78
39%
-137
- C5 -
-
6GCX
7.6
-
FAK1_CHICK
A:
[18-263]
----------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
P
E
---
N
P
A
M
A
--
V
-
A
I
K
T
C
K
N
-----
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
-
I
-
T
-
E
-
N
---
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
------
F
-
S
L
D
-
L
A
-
S
L
I
L
Y
-
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
L
S
R
----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
---------
F
Q
G
V
K
N
---
N
D
----
V
I
G
R
I
E
--
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
--
T
E
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
262
Blastp_CBE
61.75
39%
-140
- C5 -
-
6I8Z
8.9
-
A:
[20-265]
----------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
P
E
---
N
P
A
L
A
--
V
-
A
I
K
T
C
K
N
---
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
-
I
-
T
-
E
-
N
---
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
------
Y
-
S
L
D
-
L
A
-
S
L
I
L
Y
-
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
---------
F
Q
G
V
K
N
---
N
D
----
V
I
G
R
I
E
--
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
--
T
E
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
263
Blastp_CBE
61.65
39%
-138
- C5 -
-
2IJM
4.9
-
B:
[20-265]
----------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
P
E
---
N
P
A
L
A
--
V
-
A
I
K
T
C
K
N
---
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
-
I
-
T
-
E
-
N
---
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
------
Y
-
S
L
D
-
L
A
-
S
L
I
L
Y
-
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
-----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
---------
F
Q
G
V
K
N
---
N
D
----
V
I
G
R
I
E
--
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
--
T
E
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
311
Blastp_CBE
61.64
39%
-138
- C5 -
-
2JKK
8.2
-
?
A:
[18-263]
----------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
P
E
---
N
P
A
M
A
--
V
-
A
I
K
T
C
K
N
---
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
-
I
-
T
-
E
-
N
---
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
------
F
-
S
L
D
-
L
A
-
S
L
I
L
Y
-
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
L
S
R
----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
---------
F
Q
G
V
K
N
---
N
D
----
V
I
G
R
I
E
--
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
--
T
E
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
276
Blastp_CBE
61.49
39%
-140
- C5 -
-
4GU6
7.5
-
B:
[21-266]
----------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
P
E
---
N
P
A
L
A
--
V
-
A
I
K
T
C
K
N
---
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
-
I
-
T
-
E
-
N
---
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
------
Y
-
S
L
D
-
L
A
-
S
L
I
L
Y
-
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
---------
F
Q
G
V
K
N
---
N
D
----
V
I
G
R
I
E
--
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
--
T
E
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
286
Blastp_CBE
61.40
39%
-136
- C5 -
-
2JKQ
7.9
-
A:
[18-263]
----------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
P
E
---
N
P
A
L
A
--
V
-
A
I
K
T
C
K
N
---
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
-
I
-
T
-
E
-
N
---
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
------
Y
-
S
L
D
-
L
A
-
S
L
I
L
Y
-
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
-----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
---------
F
Q
G
V
K
N
---
N
D
----
V
I
G
R
I
E
--
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
--
T
E
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
281
Blastp_CBE
61.36
39%
-139
- C5 -
-
2JKM
8.2
-
A:
[18-263]
----------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
P
E
---
N
P
A
M
A
--
V
-
A
I
K
T
C
K
N
---
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
-
I
-
T
-
E
-
N
---
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
------
Y
-
S
L
D
-
L
A
-
S
L
I
L
Y
-
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
---------
F
Q
G
V
K
N
---
N
D
----
V
I
G
R
I
E
--
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
--
T
E
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
289
Blastp_CBE
61.24
39%
-139
- C5 -
-
4EBW
7.0
-
A:
[46-291]
----------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
-----
N
P
A
L
A
--
V
-
A
I
K
T
C
K
N
---
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
-
I
-
T
-
E
-
N
---
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
------
Y
-
S
L
D
-
L
A
-
S
L
I
L
Y
-
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
-----------------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
---------
F
Q
G
V
K
N
---
N
D
----
V
I
G
R
I
E
--
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
--
T
E
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
303
Blastp_CBE
61.14
39%
-133
- C5 -
-
4D4V
4.6
-
B:
[18-263]
----------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
P
E
---
N
P
A
M
A
--
V
-
A
I
K
T
C
K
N
---
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
-
I
-
T
-
E
-
N
---
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
------
F
-
S
L
D
-
L
A
-
S
L
I
L
Y
-
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
-------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
---------
F
Q
G
V
K
N
---
N
D
----
V
I
G
R
I
E
--
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
--
T
E
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
163
Blastp_CBE
61.09
39%
-127
- C5 -
-
6P1L
6.0
-
?
C:
[7-272]
--------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
----
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
P
E
---
G
E
K
V
K
--
I
-
P
V
A
I
K
E
L
-
R
-------
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
------
D
-
N
I
G
-
S
Q
-
Y
L
L
N
W
-
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
------------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
---------
Y
D
G
I
P
A
---
S
E
----
I
S
S
I
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
-----
R
E
L
I
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
544
HHSearch
60.99
36%
-55
- C5 -
-
2QOC
5.0
-
A:
[13-280]
-----------------------------------------------------------------------------------------------------------------------------
L
D
A
T
N
I
S
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
P
S
---
K
K
E
I
S
--
V
-
A
I
K
T
L
K
V
-
G
Y
T
--
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
-
D
H
P
N
I
I
R
L
E
G
V
-
V
-
T
-
K
-
S
---
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
H
D
------
A
-
Q
F
T
-
V
I
-
Q
L
V
G
M
-
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
-----------
K
I
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
---------
Y
W
E
M
S
N
---
Q
D
----
V
I
K
A
V
D
--
E
-
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
--
E
Q
I
V
S
I
L
D
K
L
I
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
283
Blastp_CBE
60.94
39%
-141
- C5 -
-
4I4F
7.7
-
A:
[23-268]
----------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
------
P
A
L
A
--
V
-
A
I
K
T
C
K
N
---
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
-
I
-
T
-
E
-
N
---
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
------
Y
-
S
L
D
-
L
A
-
S
L
I
L
Y
-
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
----------------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
---------
F
Q
G
V
K
N
---
N
D
----
V
I
G
R
I
E
--
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
--
T
E
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
406
Blastp_CBE
60.90
37%
-141
- C5 -
-
5TOB
6.4
-
A:
[10-265]
-----------------------------------------------------------------------------------------------------------------------------
I
A
R
E
D
V
V
L
N
R
I
L
G
E
G
F
F
G
E
V
Y
E
G
V
Y
T
-
H
K
---
G
E
K
I
N
--
V
-
A
V
K
T
C
K
--------
D
N
K
E
K
F
M
S
E
A
V
I
M
K
N
L
-
D
H
P
H
I
V
K
L
I
G
I
-
I
-----
E
---
P
-
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
E
R
N
K
------
N
-
S
L
K
-
V
L
-
T
L
V
L
Y
-
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
A
S
P
E
C
V
K
L
G
D
F
G
--------------------
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
---------
F
F
W
L
E
N
---
K
D
----
V
I
G
V
L
E
--
K
-
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
--
T
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
464
Blastp_CBE
60.83
41%
-64
- C5 -
-
3U4W
10.9
-
A:
[7-258]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
-------
T
T
R
--
V
-
A
I
K
T
L
K
P
-
G
T
M
S
-
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
-
E
-
E
---
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
------
G
-
K
Y
L
R
L
P
-
Q
L
V
D
M
-
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--
E
D
N
E
Y
T
A
R
Q
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
---------
Y
P
G
M
V
N
---
R
E
----
V
L
D
Q
V
E
--
R
-
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
--
E
Y
L
Q
A
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
290
Blastp_CBE
60.79
39%
-136
- C5 -
-
4EBV
6.3
-
A:
[46-291]
----------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
P
E
---
N
P
A
L
A
--
V
-
A
I
K
T
C
K
N
---
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
-
I
-
T
-
E
-
N
---
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
------
Y
-
S
L
D
-
L
A
-
S
L
I
L
Y
-
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
-----------------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
---------
F
Q
G
V
K
N
---
N
D
----
V
I
G
R
I
E
--
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
--
T
E
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
261
Blastp_CBE
60.67
40%
-69
- C5 -
-
1QCF
6.5
-
HCK_HUMAN
A:
[188-439]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
----
W
M
A
T
Y
---
N
K
H
T
K
--
V
-
A
V
K
T
M
K
P
-
G
S
M
S
----
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
-
T
-
K
-
E
---
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
------
G
-
S
K
Q
P
L
P
-
K
L
I
D
F
-
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--
E
D
N
E
Y
T
A
R
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
---------
Y
P
G
M
S
N
---
P
E
----
V
I
R
A
L
E
--
R
-
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
--
E
Y
I
Q
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
322
Blastp_CBE
60.57
39%
-76
- C5 -
-
5ZJ6
9.0
-
HCK_HUMAN
A:
[23-277]
-----------------------------------------------------------------------------------------------------------------------------
I
P
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
----
W
M
A
T
Y
---
N
K
H
T
K
--
V
-
A
V
K
T
M
K
P
-
G
S
M
S
----
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
-
T
-
K
-
E
---
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
------
G
-
S
K
Q
P
L
P
-
K
L
I
D
F
-
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--
E
D
N
E
Y
T
A
R
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
---------
Y
P
G
M
S
N
---
P
E
----
V
I
R
A
L
E
--
R
-
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
--
E
Y
I
Q
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
321
Blastp_CBE
60.55
39%
-75
- C5 -
-
5ZJ6
8.9
-
HCK_HUMAN
B:
[23-277]
-----------------------------------------------------------------------------------------------------------------------------
I
P
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
----
W
M
A
T
Y
---
N
K
H
T
K
--
V
-
A
V
K
T
M
K
P
-
G
S
M
S
----
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
-
T
-
K
-
E
---
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
------
G
-
S
K
Q
P
L
P
-
K
L
I
D
F
-
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--
E
D
N
E
Y
T
A
R
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
---------
Y
P
G
M
S
N
---
P
E
----
V
I
R
A
L
E
--
R
-
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
--
E
Y
I
Q
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
288
Blastp_CBE
60.34
39%
-68
- C5 -
-
2HK5
9.0
-
HCK_HUMAN
A:
[12-266]
-----------------------------------------------------------------------------------------------------------------------------
I
P
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
----
W
M
A
T
Y
---
N
K
H
T
K
--
V
-
A
V
K
T
M
K
P
-
G
S
M
S
----
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
-
T
-
K
-
E
---
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
------
G
-
S
K
Q
P
L
P
-
K
L
I
D
F
-
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--
E
D
N
E
Y
T
A
R
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
---------
Y
P
G
M
S
N
---
P
E
----
V
I
R
A
L
E
--
R
-
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
--
E
Y
I
Q
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
273
Blastp_CBE
60.27
39%
-138
- C5 -
-
3BZ3
6.4
-
A:
[15-260]
----------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
P
-------
L
A
--
V
-
A
I
K
T
C
K
N
---
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
-
I
-
T
-
E
-
N
---
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
------
Y
-
S
L
D
-
L
A
-
S
L
I
L
Y
-
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
---------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
---------
F
Q
G
V
K
N
---
N
D
----
V
I
G
R
I
E
--
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
--
T
E
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
228
Blastp_CBE
60.18
40%
-68
- C5 -
-
5H0E
9.5
-
HCK_HUMAN
A:
[188-439]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
----
W
M
A
T
Y
---
N
K
H
T
K
--
V
-
A
V
K
T
M
K
P
-
G
S
M
S
----
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
-
T
-
K
-
E
---
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
------
G
-
S
K
Q
P
L
P
-
K
L
I
D
F
-
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--
E
D
N
E
Y
T
A
R
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
---------
Y
P
G
M
S
N
---
P
E
----
V
I
R
A
L
E
--
R
-
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
--
E
Y
I
Q
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
477
Blastp_CBE
60.15
41%
-63
- C5 -
-
4U5J
5.8
-
SRC_CHICK
A:
[18-269]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
-------
T
T
R
--
V
-
A
I
K
T
L
K
P
-
G
T
M
S
-
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
-
E
-
E
---
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
------
G
-
K
Y
L
R
L
P
-
Q
L
V
D
M
-
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--
E
--------
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
---------
Y
P
G
M
V
N
---
R
E
----
V
L
D
Q
V
E
--
R
-
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
--
E
Y
L
Q
A
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
285
Blastp_CBE
59.94
39%
-133
- C5 -
-
1MP8
6.2
-
A:
[23-268]
----------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
P
-----
P
A
L
A
--
V
-
A
I
K
T
C
K
N
---
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
-
I
-
T
-
E
-
N
---
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
------
Y
-
S
L
D
-
L
A
-
S
L
I
L
Y
-
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
---------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
---------
F
Q
G
V
K
N
---
N
D
----
V
I
G
R
I
E
--
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
--
T
E
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
226
Blastp_CBE
59.92
40%
-68
- C5 -
-
5H0H
10.0
-
HCK_HUMAN
A:
[188-439]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
----
W
M
A
T
Y
---
N
K
H
T
K
--
V
-
A
V
K
T
M
K
P
-
G
S
M
S
----
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
-
T
-
K
-
E
---
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
------
G
-
S
K
Q
P
L
P
-
K
L
I
D
F
-
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--
E
D
N
E
Y
T
A
R
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
---------
Y
P
G
M
S
N
---
P
E
----
V
I
R
A
L
E
--
R
-
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
--
E
Y
I
Q
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
229
Blastp_CBE
59.83
40%
-66
- C5 -
-
5H0B
10.1
-
HCK_HUMAN
A:
[188-439]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
----
W
M
A
T
Y
---
N
K
H
T
K
--
V
-
A
V
K
T
M
K
P
-
G
S
M
S
----
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
-
T
-
K
-
E
---
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
------
G
-
S
K
Q
P
L
P
-
K
L
I
D
F
-
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--
E
D
N
E
Y
T
A
R
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
---------
Y
P
G
M
S
N
---
P
E
----
V
I
R
A
L
E
--
R
-
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
--
E
Y
I
Q
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
230
Blastp_CBE
59.47
40%
-65
- C5 -
-
5H09
9.9
-
HCK_HUMAN
A:
[188-439]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
----
W
M
A
T
Y
---
N
K
H
T
K
--
V
-
A
V
K
T
M
K
P
-
G
S
M
S
----
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
-
T
-
K
-
E
---
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
------
G
-
S
K
Q
P
L
P
-
K
L
I
D
F
-
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--
E
D
N
E
Y
T
A
R
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
---------
Y
P
G
M
S
N
---
P
E
----
V
I
R
A
L
E
--
R
-
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
--
E
Y
I
Q
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
227
Blastp_CBE
59.33
40%
-65
- C5 -
-
5H0G
9.5
-
HCK_HUMAN
A:
[188-439]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
----
W
M
A
T
Y
---
N
K
H
T
K
--
V
-
A
V
K
T
M
K
P
-
G
S
M
S
----
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
-
T
-
K
-
E
---
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
------
G
-
S
K
Q
P
L
P
-
K
L
I
D
F
-
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--
E
D
N
E
Y
T
A
R
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
---------
Y
P
G
M
S
N
---
P
E
----
V
I
R
A
L
E
--
R
-
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
--
E
Y
I
Q
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
545
HHSearch
58.92
36%
-57
- C5 -
-
4P5Q
6.8
-
A:
[29-302]
------------------------------------------------------------------------------------------------------------------------
E
----
L
D
A
T
N
I
S
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
P
S
---
K
K
E
I
S
--
V
-
A
I
K
T
L
K
V
-
G
Y
T
--
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
-
D
H
P
N
I
I
R
L
E
G
V
-
V
-
T
-
K
-
S
---
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
H
D
------
A
-
Q
F
T
-
V
I
-
Q
L
V
G
M
-
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
----------------
I
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
---------
Y
W
E
M
S
N
---
Q
D
----
V
I
K
A
V
D
--
E
-
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
--
E
Q
I
V
S
I
L
D
K
L
I
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
505
Blastp_CBE
58.87
41%
-63
- C5 -
-
3DQX
4.1
-
SRC_CHICK
A:
[18-269]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
-------
T
T
R
--
V
-
A
I
K
T
L
K
P
-
G
T
M
S
-
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
-
E
-
E
---
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
------
G
-
K
Y
L
R
L
P
-
Q
L
V
D
M
-
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--
E
--------
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
---------
Y
P
G
M
V
N
---
R
E
----
V
L
D
Q
V
E
--
R
-
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
--
E
Y
L
Q
A
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
242
Blastp_CBE
58.82
40%
-75
- C5 -
-
3VS4
8.3
-
HCK_HUMAN
A:
[188-439]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
----
W
M
A
T
Y
---
N
K
H
T
K
--
V
-
A
V
K
T
M
K
P
-
G
S
M
S
----
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
-
T
-
K
-
E
---
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
------
G
-
S
K
Q
P
L
P
-
K
L
I
D
F
-
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--
E
-----------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
---------
Y
P
G
M
S
N
---
P
E
----
V
I
R
A
L
E
--
R
-
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
--
E
Y
I
Q
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
246
Blastp_CBE
58.73
40%
-76
- C5 -
-
3VS2
8.7
-
HCK_HUMAN
A:
[188-439]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
----
W
M
A
T
Y
---
N
K
H
T
K
--
V
-
A
V
K
T
M
K
P
-
G
S
M
S
----
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
-
T
-
K
-
E
---
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
------
G
-
S
K
Q
P
L
P
-
K
L
I
D
F
-
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
---------
Y
P
G
M
S
N
---
P
E
----
V
I
R
A
L
E
--
R
-
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
--
E
Y
I
Q
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
326
Blastp_CBE
58.70
38%
-107
- C5 -
-
2J0L
5.7
-
A:
[18-263]
----------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
P
E
---
N
P
A
M
A
--
V
-
A
I
K
T
C
K
N
---
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
-
I
-
T
-
E
-
N
---
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
------
F
-
S
L
D
-
L
A
-
S
L
I
L
Y
-
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
E
D
S
T
K
Y
---
A
S
K
G
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
---------
F
Q
G
V
K
N
---
N
D
----
V
I
G
R
I
E
--
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
--
T
E
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
500
Blastp_CBE
58.63
41%
-64
- C5 -
-
3EN4
6.7
-
SRC_CHICK
B:
[18-269]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
-------
T
T
R
--
V
-
A
I
K
T
L
K
P
-
G
T
M
S
-
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
-
E
-
E
---
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
------
G
-
K
Y
L
R
L
P
-
Q
L
V
D
M
-
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
-------------
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
---------
Y
P
G
M
V
N
---
R
E
----
V
L
D
Q
V
E
--
R
-
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
--
E
Y
L
Q
A
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
465
Blastp_CBE
58.50
41%
-65
- C5 -
-
5XP7
6.5
-
SRC_CHICK
B:
[18-269]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
-------
T
T
R
--
V
-
A
I
K
T
L
K
P
-
G
T
M
S
-
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
-
E
-
E
---
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
------
G
-
K
Y
L
R
L
P
-
Q
L
V
D
M
-
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--
E
-----------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
---------
Y
P
G
M
V
N
---
R
E
----
V
L
D
Q
V
E
--
R
-
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
--
E
Y
L
Q
A
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
491
Blastp_CBE
58.43
41%
-68
- C5 -
-
3G6G
12.0
-
SRC_CHICK
A:
[18-269]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
-------
T
T
R
--
V
-
A
I
K
T
L
K
P
-
G
T
M
S
-
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
-
E
-
E
---
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
------
G
-
K
Y
L
R
L
P
-
Q
L
V
D
M
-
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
----------------
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
---------
Y
P
G
M
V
N
---
R
E
----
V
L
D
Q
V
E
--
R
-
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
--
E
Y
L
Q
A
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
258
Blastp_CBE
58.42
40%
-74
- C5 -
-
2C0O
10.5
-
HCK_HUMAN
A:
[188-439]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
----
W
M
A
T
Y
---
N
K
H
T
K
--
V
-
A
V
K
T
M
K
P
-
G
S
M
S
----
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
-
T
-
K
-
E
---
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
------
G
-
S
K
Q
P
L
P
-
K
L
I
D
F
-
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
---------
Y
P
G
M
S
N
---
P
E
----
V
I
R
A
L
E
--
R
-
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
--
E
Y
I
Q
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
314
Blastp_CBE
58.40
40%
-25
- C5 -
-
3PP0
9.8
-
B:
[5-274]
----------------------------------------------------------------------------------------------------------------
A
P
N
Q
A
L
L
R
I
----
L
K
E
T
E
L
R
K
V
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
-
I
P
D
---
G
E
N
V
K
IP
V
-
A
I
K
V
L
R
E
-
N
--
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
G
V
-
G
S
P
Y
V
S
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
V
T
Q
L
M
P
Y
G
C
L
L
D
H
V
R
E
N
R
------
G
-
R
L
G
-
S
Q
-
D
L
L
N
W
-
C
M
Q
I
A
K
G
M
S
Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
D
I
D
E
T
E
Y
-
H
A
--
G
K
V
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
K
P
---------
Y
D
G
I
P
A
---
R
E
----
I
P
D
L
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
S
E
C
R
P
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
260
Blastp_CBE
58.30
40%
-74
- C5 -
-
2C0I
10.8
-
HCK_HUMAN
A:
[188-439]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
----
W
M
A
T
Y
---
N
K
H
T
K
--
V
-
A
V
K
T
M
K
P
-
G
S
M
S
----
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
-
T
-
K
-
E
---
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
------
G
-
S
K
Q
P
L
P
-
K
L
I
D
F
-
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
---------
Y
P
G
M
S
N
---
P
E
----
V
I
R
A
L
E
--
R
-
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
--
E
Y
I
Q
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
256
Blastp_CBE
58.25
40%
-77
- C5 -
-
2C0T
10.8
-
HCK_HUMAN
A:
[188-439]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
----
W
M
A
T
Y
---
N
K
H
T
K
--
V
-
A
V
K
T
M
K
P
-
G
S
M
S
----
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
-
T
-
K
-
E
---
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
------
G
-
S
K
Q
P
L
P
-
K
L
I
D
F
-
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
---------
Y
P
G
M
S
N
---
P
E
----
V
I
R
A
L
E
--
R
-
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
--
E
Y
I
Q
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
243
Blastp_CBE
58.26
40%
-72
- C5 -
-
3VS3
8.8
-
HCK_HUMAN
B:
[188-439]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
----
W
M
A
T
Y
---
N
K
H
T
K
--
V
-
A
V
K
T
M
K
P
-
G
S
M
S
----
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
-
T
-
K
-
E
---
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
------
G
-
S
K
Q
P
L
P
-
K
L
I
D
F
-
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--
E
----------
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
---------
Y
P
G
M
S
N
---
P
E
----
V
I
R
A
L
E
--
R
-
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
--
E
Y
I
Q
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
254
Blastp_CBE
58.25
40%
-80
- C5 -
-
3VRY
8.6
-
HCK_HUMAN
A:
[188-439]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
----
W
M
A
T
Y
---
N
K
H
T
K
--
V
-
A
V
K
T
M
K
P
-
G
S
M
S
----
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
-
T
-
K
-
E
---
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
------
G
-
S
K
Q
P
L
P
-
K
L
I
D
F
-
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
---------
Y
P
G
M
S
N
---
P
E
----
V
I
R
A
L
E
--
R
-
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
--
E
Y
I
Q
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
468
Blastp_CBE
58.22
41%
-61
- C5 -
-
5XP5
4.3
-
SRC_CHICK
A:
[18-269]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
-------
T
T
R
--
V
-
A
I
K
T
L
K
P
-
G
T
M
S
-
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
-
E
-
E
---
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
------
G
-
K
Y
L
R
L
P
-
Q
L
V
D
M
-
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--
E
--------
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
---------
Y
P
G
M
V
N
---
R
E
----
V
L
D
Q
V
E
--
R
-
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
--
E
Y
L
Q
A
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
245
Blastp_CBE
58.20
40%
-80
- C5 -
-
3VS2
8.5
-
HCK_HUMAN
B:
[188-439]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
----
W
M
A
T
Y
---
N
K
H
T
K
--
V
-
A
V
K
T
M
K
P
-
G
S
M
S
----
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
-
T
-
K
-
E
---
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
------
G
-
S
K
Q
P
L
P
-
K
L
I
D
F
-
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
---------
Y
P
G
M
S
N
---
P
E
----
V
I
R
A
L
E
--
R
-
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
--
E
Y
I
Q
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
504
Blastp_CBE
58.11
41%
-59
- C5 -
-
3DQX
4.0
-
SRC_CHICK
B:
[18-269]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
-------
T
T
R
--
V
-
A
I
K
T
L
K
P
-
G
T
M
S
-
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
-
E
-
E
---
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
------
G
-
K
Y
L
R
L
P
-
Q
L
V
D
M
-
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--
E
-------
Q
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
---------
Y
P
G
M
V
N
---
R
E
----
V
L
D
Q
V
E
--
R
-
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
--
E
Y
L
Q
A
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
244
Blastp_CBE
58.11
40%
-80
- C5 -
-
3VS3
9.1
-
HCK_HUMAN
A:
[188-439]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
----
W
M
A
T
Y
---
N
K
H
T
K
--
V
-
A
V
K
T
M
K
P
-
G
S
M
S
----
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
-
T
-
K
-
E
---
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
------
G
-
S
K
Q
P
L
P
-
K
L
I
D
F
-
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
---------
Y
P
G
M
S
N
---
P
E
----
V
I
R
A
L
E
--
R
-
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
--
E
Y
I
Q
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
255
Blastp_CBE
58.10
40%
-78
- C5 -
-
2C0T
10.0
-
HCK_HUMAN
B:
[188-439]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
----
W
M
A
T
Y
---
N
K
H
T
K
--
V
-
A
V
K
T
M
K
P
-
G
S
M
S
----
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
-
T
-
K
-
E
---
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
------
G
-
S
K
Q
P
L
P
-
K
L
I
D
F
-
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
---------
Y
P
G
M
S
N
---
P
E
----
V
I
R
A
L
E
--
R
-
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
--
E
Y
I
Q
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
469
Blastp_CBE
58.01
41%
-69
- C5 -
-
5K9I
6.5
-
SRC_CHICK
B:
[18-269]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
-------
T
T
R
--
V
-
A
I
K
T
L
K
P
-
G
T
M
S
-
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
-
E
-
E
---
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
------
G
-
K
Y
L
R
L
P
-
Q
L
V
D
M
-
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
---------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
---------
Y
P
G
M
V
N
---
R
E
----
V
L
D
Q
V
E
--
R
-
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
--
E
Y
L
Q
A
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
492
Blastp_CBE
57.98
41%
-67
- C5 -
-
3F6X
5.1
-
SRC_CHICK
D:
[18-269]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
-------
T
T
R
--
V
-
A
I
K
T
L
K
P
-
G
T
M
S
-
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
-
E
-
E
---
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
------
G
-
K
Y
L
R
L
P
-
Q
L
V
D
M
-
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--
E
----------
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
---------
Y
P
G
M
V
N
---
R
E
----
V
L
D
Q
V
E
--
R
-
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
--
E
Y
L
Q
A
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
506
Blastp_CBE
57.94
41%
-75
- C5 -
-
3D7T
8.3
-
SRC_CHICK
B:
[18-269]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
-------
T
T
R
--
V
-
A
I
K
T
L
K
P
-
G
T
M
S
-
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
-
E
-
E
---
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
------
G
-
K
Y
L
R
L
P
-
Q
L
V
D
M
-
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
-------------
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
---------
Y
P
G
M
V
N
---
R
E
----
V
L
D
Q
V
E
--
R
-
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
--
E
Y
L
Q
A
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
238
Blastp_CBE
57.96
40%
-80
- C5 -
-
3VS6
8.2
-
HCK_HUMAN
A:
[188-439]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
----
W
M
A
T
Y
---
N
K
H
T
K
--
V
-
A
V
K
T
M
K
P
-
G
S
M
S
----
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
-
T
-
K
-
E
---
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
------
G
-
S
K
Q
P
L
P
-
K
L
I
D
F
-
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
---------
Y
P
G
M
S
N
---
P
E
----
V
I
R
A
L
E
--
R
-
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
--
E
Y
I
Q
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
248
Blastp_CBE
57.95
40%
-80
- C5 -
-
3VS1
8.6
-
HCK_HUMAN
A:
[188-439]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
----
W
M
A
T
Y
---
N
K
H
T
K
--
V
-
A
V
K
T
M
K
P
-
G
S
M
S
----
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
-
T
-
K
-
E
---
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
------
G
-
S
K
Q
P
L
P
-
K
L
I
D
F
-
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
---------
Y
P
G
M
S
N
---
P
E
----
V
I
R
A
L
E
--
R
-
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
--
E
Y
I
Q
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
249
Blastp_CBE
57.94
40%
-74
- C5 -
-
3VS0
7.9
-
HCK_HUMAN
B:
[188-439]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
----
W
M
A
T
Y
---
N
K
H
T
K
--
V
-
A
V
K
T
M
K
P
-
G
S
M
S
----
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
-
T
-
K
-
E
---
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
------
G
-
S
K
Q
P
L
P
-
K
L
I
D
F
-
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
---------
Y
P
G
M
S
N
---
P
E
----
V
I
R
A
L
E
--
R
-
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
--
E
Y
I
Q
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
467
Blastp_CBE
57.92
41%
-61
- C5 -
-
5XP5
4.4
-
SRC_CHICK
B:
[18-269]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
-------
T
T
R
--
V
-
A
I
K
T
L
K
P
-
G
T
M
S
-
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
-
E
-
E
---
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
------
G
-
K
Y
L
R
L
P
-
Q
L
V
D
M
-
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--
E
--------
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
---------
Y
P
G
M
V
N
---
R
E
----
V
L
D
Q
V
E
--
R
-
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
--
E
Y
L
Q
A
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
253
Blastp_CBE
57.84
40%
-84
- C5 -
-
3VRY
8.6
-
HCK_HUMAN
B:
[188-439]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
----
W
M
A
T
Y
---
N
K
H
T
K
--
V
-
A
V
K
T
M
K
P
-
G
S
M
S
----
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
-
T
-
K
-
E
---
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
------
G
-
S
K
Q
P
L
P
-
K
L
I
D
F
-
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
---------
Y
P
G
M
S
N
---
P
E
----
V
I
R
A
L
E
--
R
-
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
--
E
Y
I
Q
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
252
Blastp_CBE
57.79
40%
-80
- C5 -
-
3VRZ
9.2
-
HCK_HUMAN
A:
[188-439]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
----
W
M
A
T
Y
---
N
K
H
T
K
--
V
-
A
V
K
T
M
K
P
-
G
S
M
S
----
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
-
T
-
K
-
E
---
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
------
G
-
S
K
Q
P
L
P
-
K
L
I
D
F
-
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
---------
Y
P
G
M
S
N
---
P
E
----
V
I
R
A
L
E
--
R
-
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
--
E
Y
I
Q
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
241
Blastp_CBE
57.73
40%
-82
- C5 -
-
3VS4
8.5
-
HCK_HUMAN
B:
[188-439]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
----
W
M
A
T
Y
---
N
K
H
T
K
--
V
-
A
V
K
T
M
K
P
-
G
S
M
S
----
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
-
T
-
K
-
E
---
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
------
G
-
S
K
Q
P
L
P
-
K
L
I
D
F
-
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
---------
Y
P
G
M
S
N
---
P
E
----
V
I
R
A
L
E
--
R
-
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
--
E
Y
I
Q
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
435
Blastp_CBE
57.52
39%
-76
- C5 -
-
2OG8
10.2
-
LCK_HUMAN
A:
[5-259]
-----------------------------------------------------------------------------------------------------------------------------
V
P
R
E
T
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
H
T
-------
K
--
V
-
A
V
K
S
L
K
Q
-
G
S
M
S
P
----
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
-
V
-
T
-
Q
-
E
---
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
------
G
I
K
L
T
-
I
N
-
K
L
L
D
M
-
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
-------------------
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
---------
Y
P
G
M
T
N
---
P
E
----
V
I
Q
N
L
E
--
R
-
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
--
D
Y
L
R
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
259
Blastp_CBE
57.42
40%
-71
- C5 -
-
2C0I
11.0
-
HCK_HUMAN
B:
[188-439]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
----
W
M
A
T
Y
---
N
K
H
T
K
--
V
-
A
V
K
T
M
K
P
-
G
S
M
S
----
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
-
T
-
K
-
E
---
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
------
G
-
S
K
Q
P
L
P
-
K
L
I
D
F
-
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
---------
Y
P
G
M
S
N
---
P
E
----
V
I
R
A
L
E
--
R
-
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
--
E
Y
I
Q
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
487
Blastp_CBE
57.35
41%
-66
- C5 -
-
3UQG
4.0
-
SRC_CHICK
A:
[18-269]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
-------
T
T
R
--
V
-
A
I
K
T
L
K
P
-
G
T
M
S
-
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
-
E
-
E
---
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
------
G
-
K
Y
L
R
L
P
-
Q
L
V
D
M
-
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
---------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
---------
Y
P
G
M
V
N
---
R
E
----
V
L
D
Q
V
E
--
R
-
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
--
E
Y
L
Q
A
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
476
Blastp_CBE
57.38
41%
-62
- C5 -
-
4U5J
5.7
-
SRC_CHICK
B:
[18-269]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
-------
T
T
R
--
V
-
A
I
K
T
L
K
P
-
G
T
M
S
-
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
-
E
-
E
---
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
------
G
-
K
Y
L
R
L
P
-
Q
L
V
D
M
-
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--
E
--------
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
---------
Y
P
G
M
V
N
---
R
E
----
V
L
D
Q
V
E
--
R
-
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
--
E
Y
L
Q
A
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
240
Blastp_CBE
57.35
40%
-74
- C5 -
-
3VS5
8.3
-
HCK_HUMAN
A:
[188-439]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
----
W
M
A
T
Y
---
N
K
H
T
K
--
V
-
A
V
K
T
M
K
P
-
G
S
M
S
----
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
-
T
-
K
-
E
---
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
------
G
-
S
K
Q
P
L
P
-
K
L
I
D
F
-
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
---------
Y
P
G
M
S
N
---
P
E
----
V
I
R
A
L
E
--
R
-
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
--
E
Y
I
Q
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
494
Blastp_CBE
57.32
41%
-64
- C5 -
-
3F6X
4.7
-
SRC_CHICK
B:
[18-269]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
R
L
E
V
K
L
G
Q
G
C
-
G
E
V
W
M
G
T
W
N
G
-------
T
T
R
--
V
-
A
I
K
T
L
K
P
-
G
T
M
S
-
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
-
E
-
E
---
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
------
G
-
K
Y
L
R
L
P
-
Q
L
V
D
M
-
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
-------------
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
---------
Y
P
G
M
V
N
---
R
E
----
V
L
D
Q
V
E
--
R
-
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
--
E
Y
L
Q
A
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
237
Blastp_CBE
57.31
40%
-79
- C5 -
-
3VS6
8.0
-
HCK_HUMAN
B:
[188-439]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
----
W
M
A
T
Y
---
N
K
H
T
K
--
V
-
A
V
K
T
M
K
P
-
G
S
M
S
----
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
-
T
-
K
-
E
---
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
------
G
-
S
K
Q
P
L
P
-
K
L
I
D
F
-
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
---------
Y
P
G
M
S
N
---
P
E
----
V
I
R
A
L
E
--
R
-
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
--
E
Y
I
Q
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
502
Blastp_CBE
57.28
41%
-70
- C5 -
-
3EL8
8.1
-
SRC_CHICK
A:
[18-269]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
-------
T
T
R
--
V
-
A
I
K
T
L
K
P
-
G
T
M
S
-
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
-
E
-
E
---
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
------
G
-
K
Y
L
R
L
P
-
Q
L
V
D
M
-
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
---------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
---------
Y
P
G
M
V
N
---
R
E
----
V
L
D
Q
V
E
--
R
-
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
--
E
Y
L
Q
A
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
508
Blastp_CBE
57.27
41%
-69
- C5 -
-
2OIQ
9.7
-
SRC_CHICK
A:
[18-269]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
-------
T
T
R
--
V
-
A
I
K
T
L
K
P
-
G
T
M
S
-
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
-
E
-
E
---
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
------
G
-
K
Y
L
R
L
P
-
Q
L
V
D
M
-
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
---------------
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
---------
Y
P
G
M
V
N
---
R
E
----
V
L
D
Q
V
E
--
R
-
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
--
E
Y
L
Q
A
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
463
Blastp_CBE
57.22
41%
-73
- C5 -
-
3U51
8.7
-
SRC_CHICK
A:
[7-258]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
-------
T
T
R
--
V
-
A
I
K
T
L
K
P
-
G
T
M
S
-
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
-
E
-
E
---
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
------
G
-
K
Y
L
R
L
P
-
Q
L
V
D
M
-
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
---------
Y
P
G
M
V
N
---
R
E
----
V
L
D
Q
V
E
--
R
-
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
--
E
Y
L
Q
A
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
455
Blastp_CBE
57.18
41%
-61
- C5 -
-
2BDJ
9.6
-
SRC_HUMAN
A:
[11-262]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
-------
T
T
R
--
V
-
A
I
K
T
L
K
P
-
G
T
M
S
-
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
-
E
-
E
---
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
------
G
-
K
Y
L
R
L
P
-
Q
L
V
D
M
-
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--
E
-----------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
---------
Y
P
G
M
V
N
---
R
E
----
V
L
D
Q
V
E
--
R
-
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
--
E
Y
L
Q
A
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
550
HHSearch
57.13
37%
-65
- C5 -
-
6JMF
6.9
-
A:
[107-371]
-----------------------------------------------------------------------------------------------------------------------
W
V
----
L
N
H
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
-
D
-----
N
T
L
--
V
-
A
V
K
S
C
R
E
-
T
L
--
P
P
D
L
K
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
H
P
N
I
V
R
L
I
G
V
-
C
-
T
-
Q
-
K
---
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
G
------
A
-
R
L
R
-
V
K
-
T
L
L
Q
M
-
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
-
A
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
---------
Y
P
N
L
S
N
---
Q
Q
----
T
R
E
F
V
E
--
K
-
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
--
S
T
I
Y
Q
E
L
Q
S
I
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
247
Blastp_CBE
57.17
40%
-84
- C5 -
-
3VS1
8.3
-
HCK_HUMAN
B:
[188-439]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
----
W
M
A
T
Y
---
N
K
H
T
K
--
V
-
A
V
K
T
M
K
P
-
G
S
M
S
----
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
-
T
-
K
-
E
---
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
------
G
-
S
K
Q
P
L
P
-
K
L
I
D
F
-
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
---------
Y
P
G
M
S
N
---
P
E
----
V
I
R
A
L
E
--
R
-
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
--
E
Y
I
Q
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
257
Blastp_CBE
57.14
40%
-74
- C5 -
-
2C0O
10.5
-
HCK_HUMAN
B:
[188-439]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
----
W
M
A
T
Y
---
N
K
H
T
K
--
V
-
A
V
K
T
M
K
P
-
G
S
M
S
----
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
-
T
-
K
-
E
---
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
------
G
-
S
K
Q
P
L
P
-
K
L
I
D
F
-
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
---------
Y
P
G
M
S
N
---
P
E
----
V
I
R
A
L
E
--
R
-
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
--
E
Y
I
Q
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
466
Blastp_CBE
57.15
41%
-66
- C5 -
-
5XP7
4.8
-
SRC_CHICK
A:
[18-269]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
-------
T
T
R
--
V
-
A
I
K
T
L
K
P
-
G
T
M
S
-
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
-
E
-
E
---
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
------
G
-
K
Y
L
R
L
P
-
Q
L
V
D
M
-
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
---------
Y
P
G
M
V
N
---
R
E
----
V
L
D
Q
V
E
--
R
-
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
--
E
Y
L
Q
A
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
529
Blastp_CBE
57.10
39%
-64
- C5 -
-
2OF4
6.2
-
LCK_HUMAN
A:
[10-264]
-----------------------------------------------------------------------------------------------------------------------------
V
P
R
E
T
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
H
T
-------
K
--
V
-
A
V
K
S
L
K
Q
-
G
S
M
S
P
----
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
-
V
-
T
-
Q
-
E
---
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
------
G
I
K
L
T
-
I
N
-
K
L
L
D
M
-
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
--
E
D
N
E
Y
T
A
R
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
---------
Y
P
G
M
T
N
---
P
E
----
V
I
Q
N
L
E
--
R
-
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
--
D
Y
L
R
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
234
Blastp_CBE
57.14
40%
-75
- C5 -
-
4LUD
4.5
-
HCK_HUMAN
A:
[188-439]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
----
W
M
A
T
Y
---
N
K
H
T
K
--
V
-
A
V
K
T
M
K
P
----
S
----
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
-
T
-
K
-
E
---
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
------
G
-
S
K
Q
P
L
P
-
K
L
I
D
F
-
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
---------
Y
P
G
M
S
N
---
P
E
--------
L
E
--
R
-
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
--
E
Y
I
Q
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
239
Blastp_CBE
57.13
40%
-71
- C5 -
-
3VS5
8.5
-
HCK_HUMAN
B:
[188-439]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
----
W
M
A
T
Y
---
N
K
H
T
K
--
V
-
A
V
K
T
M
K
P
-
G
S
M
S
----
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
-
T
-
K
-
E
---
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
------
G
-
S
K
Q
P
L
P
-
K
L
I
D
F
-
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
---------
Y
P
G
M
S
N
---
P
E
----
V
I
R
A
L
E
--
R
-
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
--
E
Y
I
Q
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
472
Blastp_CBE
57.11
41%
-72
- C5 -
-
5J5S
9.4
-
SRC_CHICK
A:
[18-269]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
-------
T
T
R
--
V
-
A
I
K
T
L
K
P
-
G
T
M
S
-
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
-
E
-
E
---
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
------
G
-
K
Y
L
R
L
P
-
Q
L
V
D
M
-
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
--------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
---------
Y
P
G
M
V
N
---
R
E
----
V
L
D
Q
V
E
--
R
-
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
--
E
Y
L
Q
A
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
470
Blastp_CBE
57.10
41%
-64
- C5 -
-
5K9I
6.1
-
SRC_CHICK
A:
[18-269]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
-------
T
T
R
--
V
-
A
I
K
T
L
K
P
-
G
T
M
S
-
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
-
E
-
E
---
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
------
G
-
K
Y
L
R
L
P
-
Q
L
V
D
M
-
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
---------
Y
P
G
M
V
N
---
R
E
----
V
L
D
Q
V
E
--
R
-
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
--
E
Y
L
Q
A
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
423
Blastp_CBE
56.98
41%
-68
- C5 -
-
3GEQ
6.2
-
SRC_CHICK
B:
[18-269]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
-------
T
T
R
--
V
-
A
I
K
T
L
K
P
-
G
T
M
S
-
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
-
E
-
E
---
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
------
G
-
K
Y
L
R
L
P
-
Q
L
V
D
M
-
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
A
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
---------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
---------
Y
P
G
M
V
N
---
R
E
----
V
L
D
Q
V
E
--
R
-
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
--
E
Y
L
Q
A
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
478
Blastp_CBE
56.94
41%
-70
- C5 -
-
4O2P
7.9
-
SRC_CHICK
B:
[18-269]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
R
L
E
V
K
L
G
Q
G
-
F
G
E
V
W
M
G
T
W
N
G
-------
T
T
R
--
V
-
A
I
K
T
L
K
P
-
G
T
M
S
-
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
-
E
-
E
---
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
------
G
-
K
Y
L
R
L
P
-
Q
L
V
D
M
-
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
---------
Y
P
G
M
V
N
---
R
E
----
V
L
D
Q
V
E
--
R
-
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
--
E
Y
L
Q
A
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
530
Blastp_CBE
56.90
39%
-61
- C5 -
-
2OF2
7.0
-
LCK_HUMAN
A:
[10-264]
-----------------------------------------------------------------------------------------------------------------------------
V
P
R
E
T
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
H
T
-------
K
--
V
-
A
V
K
S
L
K
Q
-
G
S
M
S
P
----
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
-
V
-
T
-
Q
-
E
---
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
------
G
I
K
L
T
-
I
N
-
K
L
L
D
M
-
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
--
E
D
N
E
Y
T
A
R
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
---------
Y
P
G
M
T
N
---
P
E
----
V
I
Q
N
L
E
--
R
-
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
--
D
Y
L
R
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
454
Blastp_CBE
56.86
39%
-61
- C5 -
-
3KEX
5.0
-
ERBB3_HUMAN
A:
[4-269]
-------------------------------------------------------------------------------------------------------------------
K
V
L
A
R
I
----
F
K
E
T
E
L
R
K
L
K
V
L
G
S
G
V
F
G
T
V
H
K
G
V
W
-
I
P
E
---
G
E
S
I
K
--
I
-
P
V
-
C
I
K
V
I
E
D
K
S
G
R
Q
S
F
Q
A
V
T
D
H
M
L
A
I
G
S
L
-
D
H
A
H
I
V
R
L
L
G
L
-
C
-
P
-
G
-
S
---
S
-
L
Q
L
V
T
Q
Y
L
P
L
G
S
L
L
D
H
V
R
Q
H
R
------
G
-
A
L
G
-
P
Q
-
L
L
L
N
W
-
G
V
Q
I
A
K
G
M
Y
Y
L
E
E
H
G
M
V
H
R
N
L
A
A
R
N
V
L
L
K
S
P
S
Q
V
Q
V
A
D
F
G
V
A
D
L
L
P
P
D
D
K
Q
L
L
------
T
P
I
K
W
M
A
L
E
S
I
H
F
G
K
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
E
P
---------
Y
A
G
L
R
L
---
A
E
----
V
P
D
L
L
E
--
K
-
G
E
R
L
A
Q
P
Q
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
E
N
I
R
P
T
F
--
K
E
L
A
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
493
Blastp_CBE
56.85
41%
-60
- C5 -
-
3F6X
5.1
-
SRC_CHICK
C:
[18-269]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
-------
T
T
R
--
V
-
A
I
K
T
L
K
P
------
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
-
E
-
E
---
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
------
G
-
K
Y
L
R
L
P
-
Q
L
V
D
M
-
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--
E
----------
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
---------
Y
P
G
M
V
N
---
R
E
----
V
L
D
Q
V
E
--
R
-
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
--
E
Y
L
Q
A
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
434
Blastp_CBE
56.82
39%
-70
- C5 -
-
2OG8
9.5
-
?
B:
[5-259]
-----------------------------------------------------------------------------------------------------------------------------
V
P
R
E
T
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
H
T
-------
K
--
V
-
A
V
K
S
L
K
Q
-
G
S
M
S
P
----
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
-
V
-
T
-
Q
-
E
---
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
------
G
I
K
L
T
-
I
N
-
K
L
L
D
M
-
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
------------------
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
---------
Y
P
G
M
T
N
---
P
E
----
V
I
Q
N
L
E
--
R
-
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
--
D
Y
L
R
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
235
Blastp_CBE
56.71
40%
-70
- C5 -
-
3VS7
6.5
-
HCK_HUMAN
B:
[188-439]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
----
W
M
A
T
Y
---
N
K
H
T
K
--
V
-
A
V
K
T
M
K
P
-
G
S
M
S
----
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
-
T
-
K
-
E
---
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
------
G
-
S
K
Q
P
L
P
-
K
L
I
D
F
-
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
-----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
---------
Y
P
G
M
S
N
---
P
E
----
V
I
R
A
L
E
--
R
-
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
--
E
Y
I
Q
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
397
Blastp_CBE
56.62
41%
-39
- C5 -
-
1M52
10.1
-
ABL1_MOUSE
B:
[19-267]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
-
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
536
Blastp_CBE
56.52
40%
-62
- C5 -
-
3ACJ
4.5
-
LCK_HUMAN
A:
[21-270]
----------------------------------------------------------------------------------------------------------------------------------
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
H
T
-------
K
--
V
-
A
V
K
S
L
K
Q
-
G
S
M
S
-
P
D
A
---
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
-
V
-
T
-
Q
-
E
---
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
------
G
I
K
L
T
-
I
N
-
K
L
L
D
M
-
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
--
T
A
R
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
---------
Y
P
G
M
T
N
---
P
E
----
V
I
Q
N
L
E
--
R
-
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
--
D
Y
L
R
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
462
Blastp_CBE
56.51
41%
-71
- C5 -
-
3U51
8.3
-
B:
[7-258]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
-------
T
T
R
--
V
-
A
I
K
T
L
K
P
-
G
T
M
S
-
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
-
E
-
E
---
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
------
G
-
K
Y
L
R
L
P
-
Q
L
V
D
M
-
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
--------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
---------
Y
P
G
M
V
N
---
R
E
----
V
L
D
Q
V
E
--
R
-
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
--
E
Y
L
Q
A
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
453
Blastp_CBE
56.49
39%
-58
- C5 -
-
3KEX
4.9
-
B:
[4-270]
-------------------------------------------------------------------------------------------------------------------
K
V
L
A
R
I
----
F
K
E
T
E
L
R
K
L
K
V
L
G
S
G
V
F
G
T
V
H
K
G
V
W
-
I
P
E
---
G
E
S
I
K
--
I
-
P
V
-
C
I
K
V
I
E
D
K
S
G
R
Q
S
F
Q
A
V
T
D
H
M
L
A
I
G
S
L
-
D
H
A
H
I
V
R
L
L
G
L
-
C
-
P
-
G
-
S
---
S
-
L
Q
L
V
T
Q
Y
L
P
L
G
S
L
L
D
H
V
R
Q
H
R
------
G
-
A
L
G
-
P
Q
-
L
L
L
N
W
-
G
V
Q
I
A
K
G
M
Y
Y
L
E
E
H
G
M
V
H
R
N
L
A
A
R
N
V
L
L
K
S
P
S
Q
V
Q
V
A
D
F
G
V
A
D
L
L
P
P
D
D
K
Q
--------
T
P
I
K
W
M
A
L
E
S
I
H
F
G
K
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
E
P
---------
Y
A
G
L
R
L
---
A
E
----
V
P
D
L
L
E
--
K
-
G
E
R
L
A
Q
P
Q
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
E
N
I
R
P
T
F
--
K
E
L
A
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
498
Blastp_CBE
56.46
41%
-68
- C5 -
-
3EN5
6.3
-
SRC_CHICK
B:
[18-269]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
-------
T
T
R
--
V
-
A
I
K
T
L
K
P
-
G
T
M
S
-
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
-
E
-
E
---
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
------
G
-
K
Y
L
R
L
P
-
Q
L
V
D
M
-
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
---------
Y
P
G
M
V
N
---
R
E
----
V
L
D
Q
V
E
--
R
-
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
--
E
Y
L
Q
A
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
513
Blastp_CBE
56.42
41%
-76
- C5 -
-
5T0P
6.4
-
SRC_CHICK
A:
[18-269]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
-------
T
T
R
--
V
-
A
I
K
T
L
K
P
-
G
T
M
S
-
P
E
A
---
F
L
Q
E
A
Q
C
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
-
E
-
E
---
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
------
G
-
K
Y
L
R
L
P
-
Q
L
V
D
M
-
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
---------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
---------
Y
P
G
M
V
N
---
R
E
----
V
L
D
Q
V
E
--
R
-
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
--
E
Y
L
Q
A
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
398
Blastp_CBE
56.45
41%
-33
- C5 -
-
1M52
10.0
-
ABL1_MOUSE
A:
[19-267]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
-
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
236
Blastp_CBE
56.42
40%
-72
- C5 -
-
3VS7
6.5
-
HCK_HUMAN
A:
[188-439]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
----
W
M
A
T
Y
---
N
K
H
T
K
--
V
-
A
V
K
T
M
K
P
-
G
S
M
S
----
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
-
T
-
K
-
E
---
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
------
G
-
S
K
Q
P
L
P
-
K
L
I
D
F
-
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
---------
Y
P
G
M
S
N
---
P
E
----
V
I
R
A
L
E
--
R
-
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
--
E
Y
I
Q
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
233
Blastp_CBE
56.34
40%
-71
- C5 -
-
4LUD
5.8
-
HCK_HUMAN
B:
[188-439]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
----
W
M
A
T
Y
---
N
K
H
T
K
--
V
-
A
V
K
T
M
K
P
-
G
--
S
----
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
-
T
-
K
-
E
---
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
------
G
-
S
K
Q
P
L
P
-
K
L
I
D
F
-
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
---------
Y
P
G
M
S
N
---
P
E
----
V
I
R
A
L
E
--
R
-
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
--
E
Y
I
Q
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
422
Blastp_CBE
56.31
40%
-68
- C5 -
-
2PL0
9.3
-
LCK_HUMAN
A:
[25-274]
----------------------------------------------------------------------------------------------------------------------------------
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
H
T
-------
K
--
V
-
A
V
K
S
L
K
Q
-
G
S
M
S
-
P
D
A
---
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
-
V
-
T
-
Q
-
E
---
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
------
G
I
K
L
T
-
I
N
-
K
L
L
D
M
-
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
--
E
D
N
E
Y
T
A
R
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
---------
Y
P
G
M
T
N
---
P
E
----
V
I
Q
N
L
E
--
R
-
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
--
D
Y
L
R
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
474
Blastp_CBE
56.30
41%
-71
- C5 -
-
4YBJ
10.1
-
SRC_CHICK
B:
[18-269]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
-------
T
T
R
--
V
-
A
I
K
------
T
M
S
-
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
-
E
-
E
---
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
------
G
-
K
Y
L
R
L
P
-
Q
L
V
D
M
-
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
---------
Y
P
G
M
V
N
---
R
E
----
V
L
D
Q
V
E
--
R
-
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
--
E
Y
L
Q
A
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
250
Blastp_CBE
56.29
40%
-70
- C5 -
-
3VS0
8.6
-
HCK_HUMAN
A:
[188-439]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
----
W
M
A
T
Y
---
N
K
H
T
K
--
V
-
A
V
K
T
M
K
P
-
G
S
M
S
----
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
-
T
-
K
-
E
---
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
------
G
-
S
K
Q
P
L
P
-
K
L
I
D
F
-
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
---------
Y
P
G
M
S
N
---
P
E
----
V
I
R
A
L
E
--
R
-
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
--
E
Y
I
Q
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
512
Blastp_CBE
56.28
41%
-72
- C5 -
-
5T0P
6.3
-
SRC_CHICK
B:
[18-269]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
-------
T
T
R
--
V
-
A
I
K
T
L
K
P
-
G
T
M
S
-
P
E
A
---
F
L
Q
E
A
Q
C
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
-
E
-
E
---
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
------
G
-
K
Y
L
R
L
P
-
Q
L
V
D
M
-
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
---------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
---------
Y
P
G
M
V
N
---
R
E
----
V
L
D
Q
V
E
--
R
-
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
--
E
Y
L
Q
A
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
339
Blastp_CBE
56.09
40%
-33
- C5 -
-
2ZV8
3.8
-
LYN_MOUSE
A:
[9-264]
-----------------------------------------------------------------------------------------------------------------------------
I
P
R
E
S
I
K
L
V
K
K
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-------
N
S
T
K
--
V
-
A
V
K
T
L
K
P
-
G
T
M
S
----
V
Q
A
F
L
E
E
A
N
L
M
K
T
L
-
Q
H
D
K
L
V
R
L
Y
A
V
-
V
-
T
-
K
-
E
E--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
------
G
G
K
V
L
-
L
P
-
K
L
I
D
F
-
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
I
---------
R
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
N
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
---------
Y
P
G
R
T
N
---
A
D
----
V
M
S
A
L
---
S
Q
G
Y
R
M
P
R
M
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
--
D
Y
L
Q
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
490
Blastp_CBE
56.08
41%
-67
- C5 -
-
3G6G
12.5
-
SRC_CHICK
B:
[18-269]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
-------
T
T
R
--
V
-
A
I
K
T
L
K
P
-
G
T
M
S
-
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
-
E
-
E
---
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
------
G
-
K
Y
L
R
L
P
-
Q
L
V
D
M
-
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
-----------------
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
---------
Y
P
G
M
V
N
---
R
E
----
V
L
D
Q
V
E
--
R
-
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
--
E
Y
L
Q
A
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
501
Blastp_CBE
56.04
41%
-68
- C5 -
-
3EN4
6.6
-
SRC_CHICK
A:
[18-269]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
-------
T
T
R
--
V
-
A
I
K
T
L
K
P
---
M
S
-
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
-
E
-
E
---
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
------
G
-
K
Y
L
R
L
P
-
Q
L
V
D
M
-
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
---------
Y
P
G
M
V
N
---
R
E
----
V
L
D
Q
V
E
--
R
-
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
--
E
Y
L
Q
A
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
471
Blastp_CBE
55.98
41%
-68
- C5 -
-
5J5S
8.4
-
SRC_CHICK
B:
[18-269]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
R
L
E
V
K
L
G
Q
--
F
G
E
V
W
M
G
T
W
N
G
-------
T
T
R
--
V
-
A
I
K
T
L
K
P
-
G
T
M
S
-
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
-
E
-
E
---
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
------
G
-
K
Y
L
R
L
P
-
Q
L
V
D
M
-
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
--------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
---------
Y
P
G
M
V
N
---
R
E
----
V
L
D
Q
V
E
--
R
-
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
--
E
Y
L
Q
A
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
395
Blastp_CBE
55.98
41%
-33
- C5 -
-
1OPJ
10.9
-
ABL1_MOUSE
B:
[19-267]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
-
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
531
Blastp_CBE
55.96
40%
-60
- C5 -
-
3KXZ
6.7
-
LCK_HUMAN
A:
[23-272]
----------------------------------------------------------------------------------------------------------------------------------
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
H
T
-------
K
--
V
-
A
V
K
S
L
K
Q
-
G
S
M
S
-
P
D
A
---
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
-
V
-
T
-
Q
-
E
---
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
------
G
I
K
L
T
-
I
N
-
K
L
L
D
M
-
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
--
T
A
R
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
---------
Y
P
G
M
T
N
---
P
E
----
V
I
Q
N
L
E
--
R
-
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
--
D
Y
L
R
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
424
Blastp_CBE
55.93
41%
-63
- C5 -
-
3GEQ
6.2
-
SRC_CHICK
A:
[18-269]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
-------
T
T
R
--
V
-
A
I
K
T
L
K
P
-
G
T
M
S
-
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
-
E
-
E
---
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
------
G
-
K
Y
L
R
L
P
-
Q
L
V
D
M
-
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
A
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
----------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
---------
Y
P
G
M
V
N
---
R
E
----
V
L
D
Q
V
E
--
R
-
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
--
E
Y
L
Q
A
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
231
Blastp_CBE
55.94
40%
-75
- C5 -
-
4LUE
9.3
-
HCK_HUMAN
B:
[188-439]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
----
W
M
A
T
Y
---
N
K
H
T
K
--
V
-
A
V
K
T
M
K
P
-------------
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
-
T
-
K
-
E
---
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
------
G
-
S
K
Q
P
L
P
-
K
L
I
D
F
-
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------
P
I
K
W
T
A
P
E
A
I
N
---
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
---------
Y
P
G
M
S
N
---
P
E
----
V
I
R
A
L
E
--
R
-
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
--
E
Y
I
Q
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
232
Blastp_CBE
55.93
40%
-72
- C5 -
-
4LUE
9.1
-
HCK_HUMAN
A:
[188-439]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
----
W
M
A
T
Y
---
N
K
H
T
K
--
V
-
A
V
K
T
M
K
P
-
G
S
----------
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
-
T
-
K
-
E
---
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
------
G
-
S
K
Q
P
L
P
-
K
L
I
D
F
-
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
---------
Y
P
G
M
S
N
---
P
E
----
V
I
R
A
L
E
--
R
-
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
--
E
Y
I
Q
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
495
Blastp_CBE
55.91
41%
-62
- C5 -
-
3F6X
7.1
-
SRC_CHICK
A:
[18-269]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
-------
T
T
R
--
V
-
A
I
K
T
L
------
S
-
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
-
E
-
E
---
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
------
G
-
K
Y
L
R
L
P
-
Q
L
V
D
M
-
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--
E
----------
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
---------
Y
P
G
M
V
N
---
R
E
----
V
L
D
Q
V
E
--
R
-
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
--
E
Y
L
Q
A
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
485
Blastp_CBE
55.88
41%
-66
- C5 -
-
4AGW
8.8
-
SRC_CHICK
A:
[18-269]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
-------
T
T
R
--
V
-
A
I
K
T
L
K
P
-
G
T
M
S
-
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
-
E
-
E
---
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
------
G
-
K
Y
L
R
L
P
-
Q
L
V
D
M
-
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
---------
Y
P
G
M
V
N
---
R
E
----
V
L
D
Q
V
E
--
R
-
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
--
E
Y
L
Q
A
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
369
Blastp_CBE
55.84
41%
-37
- C5 -
-
4TWP
7.5
-
ABL1_HUMAN
B:
[9-257]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
-
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
416
Blastp_CBE
55.82
41%
-35
- C5 -
-
2HZI
10.4
-
ABL1_HUMAN
A:
[18-266]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
-
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
555
HHSearch
55.61
37%
-62
- C5 -
-
3CBL
8.1
-
A:
[109-373]
-----------------------------------------------------------------------------------------------------------------------
W
V
----
L
N
H
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
-
D
-----
N
T
L
--
V
-
A
V
K
S
C
R
E
-
T
L
--
P
P
D
L
K
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
H
P
N
I
V
R
L
I
G
V
-
C
-
T
-
Q
-
K
---
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
G
------
A
-
R
L
R
-
V
K
-
T
L
L
Q
M
-
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
-
A
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
---------
Y
P
N
L
S
N
---
Q
Q
----
T
R
E
F
V
E
--
K
-
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
--
S
T
I
Y
Q
E
L
Q
S
I
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
433
Blastp_CBE
55.57
40%
-75
- C5 -
-
3BYS
9.4
-
LCK_HUMAN
A:
[21-270]
----------------------------------------------------------------------------------------------------------------------------------
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
H
T
-------
K
--
V
-
A
V
K
S
L
K
Q
-
G
S
M
S
-
P
D
A
---
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
-
V
-
T
-
Q
-
E
---
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
------
G
I
K
L
T
-
I
N
-
K
L
L
D
M
-
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
-------------------
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
---------
Y
P
G
M
T
N
---
P
E
----
V
I
Q
N
L
E
--
R
-
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
--
D
Y
L
R
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
488
Blastp_CBE
55.59
41%
-66
- C5 -
-
3UQF
7.1
-
SRC_CHICK
B:
[18-269]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
-------
T
T
R
--
V
-
A
I
K
T
---------
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
-
E
-
E
---
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
------
G
-
K
Y
L
R
L
P
-
Q
L
V
D
M
-
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
--------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
---------
Y
P
G
M
V
N
---
R
E
----
V
L
D
Q
V
E
--
R
-
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
--
E
Y
L
Q
A
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
337
Blastp_CBE
55.57
40%
-31
- C5 -
-
2ZVA
7.1
-
LYN_MOUSE
A:
[9-264]
-----------------------------------------------------------------------------------------------------------------------------
I
P
R
E
S
I
K
L
V
K
K
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-------
N
S
T
K
--
V
-
A
V
K
T
L
K
P
-
G
T
M
S
----
V
Q
A
F
L
E
E
A
N
L
M
K
T
L
-
Q
H
D
K
L
V
R
L
Y
A
V
-
V
-
T
-
K
-
E
E--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
------
G
G
K
V
L
-
L
P
-
K
L
I
D
F
-
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
I
--
E
----
T
A
R
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
N
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
---------
Y
P
G
R
T
N
---
A
D
----
V
M
S
A
L
---
S
Q
G
Y
R
M
P
R
M
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
--
D
Y
L
Q
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
432
Blastp_CBE
55.55
40%
-70
- C5 -
-
3BYU
9.9
-
LCK_HUMAN
A:
[21-270]
----------------------------------------------------------------------------------------------------------------------------------
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
H
T
-------
K
--
V
-
A
V
K
S
L
K
Q
-
G
S
M
S
-
P
D
A
---
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
-
V
-
T
-
Q
-
E
---
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
------
G
I
K
L
T
-
I
N
-
K
L
L
D
M
-
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
-----------------
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
---------
Y
P
G
M
T
N
---
P
E
----
V
I
Q
N
L
E
--
R
-
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
--
D
Y
L
R
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
549
HHSearch
55.51
37%
-63
- C5 -
-
3BKB
8.1
-
A:
[109-373]
-----------------------------------------------------------------------------------------------------------------------
W
V
----
L
N
H
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
-
D
-----
N
T
L
--
V
-
A
V
K
S
C
R
E
-
T
L
P
--
P
D
L
K
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
H
P
N
I
V
R
L
I
G
V
-
C
-
T
-
Q
-
K
---
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
G
------
A
-
R
L
R
-
V
K
-
T
L
L
Q
M
-
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
-
A
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
---------
Y
P
N
L
S
N
---
Q
Q
----
T
R
E
F
V
E
--
K
-
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
--
S
T
I
Y
Q
E
L
Q
S
I
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
532
Blastp_CBE
55.49
40%
-56
- C5 -
-
3AD6
5.0
-
LCK_HUMAN
A:
[21-270]
----------------------------------------------------------------------------------------------------------------------------------
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
H
T
-------
K
--
V
-
A
V
K
S
L
K
Q
-
G
S
M
S
-
P
D
A
---
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
-
V
-
T
-
Q
-
E
---
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
------
G
I
K
L
T
-
I
N
-
K
L
L
D
M
-
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
--
T
A
R
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
---------
Y
P
G
M
T
N
---
P
E
----
V
I
Q
N
L
E
--
R
-
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
--
D
Y
L
R
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
535
Blastp_CBE
55.43
40%
-58
- C5 -
-
3ACK
4.9
-
LCK_HUMAN
A:
[21-270]
----------------------------------------------------------------------------------------------------------------------------------
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
H
T
-------
K
--
V
-
A
V
K
S
L
K
Q
-
G
S
M
S
-
P
D
A
---
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
-
V
-
T
-
Q
-
E
---
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
------
G
I
K
L
T
-
I
N
-
K
L
L
D
M
-
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
--
T
A
R
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
---------
Y
P
G
M
T
N
---
P
E
----
V
I
Q
N
L
E
--
R
-
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
--
D
Y
L
R
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
419
Blastp_CBE
55.46
41%
-35
- C5 -
-
3IK3
12.1
-
ABL1_MOUSE
B:
[14-262]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
-
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
533
Blastp_CBE
55.43
40%
-58
- C5 -
-
3AD5
5.3
-
LCK_HUMAN
A:
[21-270]
----------------------------------------------------------------------------------------------------------------------------------
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
H
T
-------
K
--
V
-
A
V
K
S
L
K
Q
-
G
S
M
S
-
P
D
A
---
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
-
V
-
T
-
Q
-
E
---
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
------
G
I
K
L
T
-
I
N
-
K
L
L
D
M
-
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
--
T
A
R
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
---------
Y
P
G
M
T
N
---
P
E
----
V
I
Q
N
L
E
--
R
-
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
--
D
Y
L
R
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
534
Blastp_CBE
55.41
40%
-62
- C5 -
-
3AD4
4.7
-
LCK_HUMAN
A:
[21-270]
----------------------------------------------------------------------------------------------------------------------------------
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
H
T
-------
K
--
V
-
A
V
K
S
L
K
Q
-
G
S
M
S
-
P
D
A
---
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
-
V
-
T
-
Q
-
E
---
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
------
G
I
K
L
T
-
I
N
-
K
L
L
D
M
-
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
--
T
A
R
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
---------
Y
P
G
M
T
N
---
P
E
----
V
I
Q
N
L
E
--
R
-
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
--
D
Y
L
R
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
341
Blastp_CBE
55.37
41%
-35
- C5 -
-
4ZOG
7.3
-
ABL1_HUMAN
A:
[13-261]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
-
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
351
Blastp_CBE
55.34
41%
-31
- C5 -
-
3UE4
7.1
-
ABL1_HUMAN
B:
[16-264]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
--
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
-
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
427
Blastp_CBE
55.22
41%
-33
- C5 -
-
2G2H
9.6
-
ABL1_HUMAN
B:
[16-264]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
-
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
352
Blastp_CBE
55.22
41%
-29
- C5 -
-
3UE4
6.7
-
ABL1_HUMAN
A:
[16-264]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
-
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
360
Blastp_CBE
55.18
41%
-34
- C5 -
-
4WA9
8.6
-
ABL1_HUMAN
B:
[15-263]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
-
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
428
Blastp_CBE
55.13
41%
-32
- C5 -
-
2G2H
9.4
-
ABL1_HUMAN
A:
[16-264]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
-
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
356
Blastp_CBE
54.97
41%
-23
- C5 -
-
2G1T
7.4
-
ABL1_HUMAN
C:
[16-264]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
-
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
481
Blastp_CBE
54.91
41%
-73
- C5 -
-
4FIC
4.6
-
SRC_CHICK
A:
[18-269]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
R
L
E
V
K
L
G
Q
---
G
E
V
W
M
G
T
W
N
G
-------
T
T
R
--
V
-
A
I
K
T
L
K
P
-------------
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
-
E
-
E
---
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
------
G
-
K
Y
L
R
L
P
-
Q
L
V
D
M
-
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
---------
Y
P
G
M
V
N
---
R
E
----
V
L
D
Q
V
E
--
R
-
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
--
E
Y
L
Q
A
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
381
Blastp_CBE
54.91
41%
-33
- C5 -
-
3OY3
11.2
-
ABL1_MOUSE
A:
[14-262]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
-
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
370
Blastp_CBE
54.88
41%
-35
- C5 -
-
4TWP
7.1
-
ABL1_HUMAN
A:
[9-257]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
------
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
355
Blastp_CBE
54.88
41%
-22
- C5 -
-
2G1T
7.2
-
ABL1_HUMAN
D:
[16-264]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
-
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
503
Blastp_CBE
54.82
41%
-64
- C5 -
-
3EL7
9.6
-
SRC_CHICK
A:
[18-269]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
R
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
N
G
-------
T
T
R
--
V
-
A
I
K
T
L
K
P
--
T
M
S
-
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
-
E
-------
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
------
G
-
K
Y
L
R
L
P
-
Q
L
V
D
M
-
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
--------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
---------
Y
P
G
M
V
N
---
R
E
----
V
L
D
Q
V
E
--
R
-
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
--
E
Y
L
Q
A
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
338
Blastp_CBE
54.78
40%
-31
- C5 -
-
2ZV9
5.6
-
LYN_MOUSE
A:
[9-264]
-----------------------------------------------------------------------------------------------------------------------------
I
P
R
E
S
I
K
L
V
K
K
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-------
N
S
T
K
--
V
-
A
V
K
T
L
K
P
-
G
T
M
S
----
V
Q
A
F
L
E
E
A
N
L
M
K
T
L
-
Q
H
D
K
L
V
R
L
Y
A
V
-
V
-
T
-
K
-
E
E--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
------
G
G
K
V
L
-
L
P
-
K
L
I
D
F
-
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
I
----------
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
N
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
---------
Y
P
G
R
T
N
---
A
D
----
V
M
S
A
L
---
S
Q
G
Y
R
M
P
R
M
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
--
D
Y
L
Q
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
357
Blastp_CBE
54.75
41%
-26
- C5 -
-
2G1T
7.0
-
ABL1_HUMAN
B:
[16-264]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
-
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
396
Blastp_CBE
54.71
41%
-30
- C5 -
-
1OPJ
10.8
-
ABL1_MOUSE
A:
[19-267]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
-
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
402
Blastp_CBE
54.63
41%
-29
- C5 -
-
1FPU
8.6
-
ABL1_MOUSE
A:
[19-267]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
-
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
430
Blastp_CBE
54.60
41%
-32
- C5 -
-
2G2F
3.8
-
ABL1_HUMAN
A:
[16-264]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
-
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
527
Blastp_CBE
54.58
40%
-64
* C5 *
-
1YOL
6.4
-
SRC_HUMAN
B:
[15-266]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
R
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
N
G
-------
T
T
R
--
V
-
A
I
K
T
L
K
P
-
G
T
M
S
-
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
-
E
-
E
---
P
-
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
G
E
T
------
G
-
K
Y
L
R
L
P
-
Q
L
V
D
M
-
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
---------
Y
P
G
M
V
N
---
R
E
----
V
L
D
Q
V
E
--
R
-
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
--
E
Y
L
Q
A
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
383
Blastp_CBE
54.56
41%
-36
- C5 -
-
6HD6
11.1
-
ABL1_MOUSE
A:
[19-267]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
---
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
393
Blastp_CBE
54.54
41%
-32
- C5 -
-
3K5V
10.8
-
ABL1_MOUSE
A:
[19-267]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
-
D
-
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
421
Blastp_CBE
54.51
41%
-40
- C5 -
-
2Z60
8.4
-
ABL1_MOUSE
A:
[14-262]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
----
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
400
Blastp_CBE
54.47
41%
-34
- C5 -
-
1IEP
10.6
-
ABL1_MOUSE
A:
[19-267]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
-
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
358
Blastp_CBE
54.47
41%
-22
- C5 -
-
2G1T
7.2
-
ABL1_HUMAN
A:
[16-264]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
-
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
54.47
45%
-34
- C5 -
-
4CSV
10.2
-
?
A:
[8-257]
-----------------------------------------------------------------------------------------------------------------------------
I
P
R
S
E
I
T
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
---
R
---
N
Y
N
I
E
--
V
-
A
V
K
T
L
K
E
-
G
T
M
S
----
V
E
E
F
L
Q
E
A
Q
I
M
K
K
L
-
K
H
P
N
L
V
Q
L
Y
G
V
-
C
-
T
-
K
E
P
---
P
-
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
C
-----------
V
-
N
A
Q
A
L
L
D
M
-
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
V
K
V
A
D
F
G
-------------------
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
---------
Y
P
G
M
S
G
---
S
E
----
V
I
E
Q
V
E
--
R
-
G
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
441
Blastp_CBE
54.39
41%
-31
- C5 -
-
4XEY
7.9
-
ABL1_HUMAN
A:
[126-374]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
----
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
-
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
371
Blastp_CBE
54.38
40%
-37
- C5 -
-
3A4O
7.6
-
LYN_HUMAN
X:
[10-265]
-----------------------------------------------------------------------------------------------------------------------------
I
P
R
E
S
I
K
L
V
K
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-------
N
S
T
K
--
V
-
A
V
K
T
L
K
P
-
G
T
M
S
----
V
Q
A
F
L
E
E
A
N
L
M
K
T
L
-
Q
H
D
K
L
V
R
L
Y
A
V
-
V
-
T
R
E
-
E
---
P
-
I
Y
I
I
T
E
Y
M
A
K
G
S
L
L
D
F
L
K
S
D
E
------
G
G
K
V
L
-
L
P
-
K
L
I
D
F
-
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
-----------
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
D
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
---------
Y
P
G
R
T
N
---
A
D
----
V
M
T
A
L
---
S
Q
G
Y
R
M
P
R
V
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
--
D
Y
L
Q
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
431
Blastp_CBE
54.32
41%
-31
- C5 -
-
2F4J
7.1
-
ABL1_HUMAN
A:
[15-263]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
-
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
408
Blastp_CBE
54.34
41%
-26
- C5 -
-
3QRK
8.3
-
ABL1_HUMAN
A:
[19-267]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
-
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
420
Blastp_CBE
54.33
41%
-36
- C5 -
-
3IK3
11.8
-
ABL1_MOUSE
A:
[14-262]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
-
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
--------
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
385
Blastp_CBE
54.32
41%
-31
- C5 -
-
6HD4
11.1
-
ABL1_MOUSE
A:
[19-267]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
-
D
-
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
480
Blastp_CBE
54.31
41%
-67
- C5 -
-
4FIC
4.8
-
SRC_CHICK
B:
[18-269]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
-------
T
T
R
--
V
-
A
I
K
T
L
-------------------
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
-
E
-
E
---
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
------
G
-
K
Y
L
R
L
P
-
Q
L
V
D
M
-
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
---------
Y
P
G
M
V
N
---
R
E
----
V
L
D
Q
V
E
--
R
-
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
--
E
Y
L
Q
A
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
380
Blastp_CBE
54.26
41%
-36
- C5 -
-
3OY3
11.5
-
ABL1_MOUSE
B:
[14-262]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
-
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
442
Blastp_CBE
54.21
41%
-66
- C5 -
-
6ATE
5.4
-
SRC_HUMAN
A:
[18-269]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
-------
T
T
R
--
V
-
A
I
K
T
L
--------
P
E
A
---
F
--
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
-
E
-
E
---
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
------
G
-
K
Y
L
R
L
P
-
Q
L
V
D
M
-
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
----------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
---------
Y
P
G
M
V
N
---
R
E
----
V
L
D
Q
V
E
--
R
-
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
--
E
Y
L
Q
A
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
330
Blastp_CBE
54.22
41%
-36
- C5 -
-
6NPV
10.9
-
ABL1_HUMAN
A:
[27-275]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
----------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
364
Blastp_CBE
54.23
41%
-31
- C5 -
-
3KFA
12.9
-
ABL1_MOUSE
A:
[14-262]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
-
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
325
Blastp_CBE
54.22
40%
-28
- C5 -
-
5XY1
6.5
-
LYN_HUMAN
A:
[9-264]
-----------------------------------------------------------------------------------------------------------------------------
I
P
R
E
S
I
K
L
V
K
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-------
N
S
T
K
--
V
-
A
V
K
T
L
K
P
-
G
T
M
S
----
V
Q
A
F
L
E
E
A
N
L
M
K
T
L
-
Q
H
D
K
L
V
R
L
Y
A
V
-
V
-
T
R
E
-
E
---
P
-
I
Y
I
I
T
E
Y
M
A
K
G
S
L
L
D
F
L
K
S
D
E
------
G
G
K
V
L
-
L
P
-
K
L
I
D
F
-
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
--------------
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
D
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
---------
Y
P
G
R
T
N
---
A
D
----
V
M
T
A
L
---
S
Q
G
Y
R
M
P
R
V
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
--
D
Y
L
Q
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
409
Blastp_CBE
54.21
41%
-30
- C5 -
-
3QRI
8.4
-
ABL1_HUMAN
B:
[19-267]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
------
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
404
Blastp_CBE
54.19
41%
-35
- C5 -
-
3DK3
8.2
-
ABL1_MOUSE
A:
[12-260]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
-----
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
F
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
P
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
332
Blastp_CBE
54.13
41%
-30
- C5 -
-
6NPU
10.9
-
ABL1_HUMAN
A:
[27-275]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
----------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
390
Blastp_CBE
54.11
41%
-27
- C5 -
-
3MS9
11.1
-
ABL1_MOUSE
B:
[19-267]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
----
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
336
Blastp_CBE
54.07
41%
-31
- C5 -
-
3PYY
11.2
-
ABL1_HUMAN
A:
[27-275]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
-----
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
410
Blastp_CBE
54.01
41%
-29
- C5 -
-
3QRI
10.1
-
ABL1_HUMAN
A:
[19-267]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
-
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
528
Blastp_CBE
54.03
40%
-60
- C5 -
-
1YOL
2.7
-
SRC_HUMAN
A:
[15-266]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
R
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
N
G
-------
T
T
R
--
V
-
A
I
K
T
L
K
P
-
G
T
M
S
-
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
-
E
-
E
---
P
-
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
G
E
T
------
G
-
K
Y
L
R
L
P
-
Q
L
V
D
M
-
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
---------
Y
P
G
M
V
N
---
R
E
----
V
L
D
Q
V
E
--
R
-
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
--
E
Y
L
Q
A
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
354
Blastp_CBE
54.02
41%
-26
- C5 -
-
2HIW
9.1
-
ABL1_HUMAN
A:
[16-264]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
-
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
363
Blastp_CBE
54.01
41%
-32
- C5 -
-
3KFA
12.9
-
ABL1_MOUSE
B:
[14-262]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
-
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
328
Blastp_CBE
54.00
41%
-24
- C5 -
-
2HZ0
9.6
-
ABL1_HUMAN
A:
[14-262]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
-
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
557
HHSearch
53.81
36%
-5
- C5 -
-
5A46
5.6
-
B:
[35-322]
-----------------------------------------------------------------------------------------------------------------------
W
E
----
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
L
A
E
A
I
G
L
-DKP
N
R
V
T
K
--
V
-
A
V
K
M
L
K
S
-
D
A
T
--
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
-
C
-
T
-
Q
-
D
---
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
PPHNPE
E
-
Q
L
S
-
S
K
-
D
L
V
S
C
-
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
-
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
---------
Y
P
G
V
P
V
---
E
E
----
L
F
K
L
L
K
---
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
--
K
Q
L
V
E
D
L
D
R
I
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
347
Blastp_CBE
53.83
41%
-30
- C5 -
-
2HYY
10.6
-
ABL1_HUMAN
B:
[14-262]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
--
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
53.81
45%
-40
- C5 -
-
4UEU
3.8
-
?
A:
[8-257]
-----------------------------------------------------------------------------------------------------------------------------
I
P
R
S
E
I
T
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
---
R
---
N
Y
N
I
E
--
V
-
A
V
K
T
L
K
E
-
G
T
M
S
----
V
E
E
F
L
Q
E
A
Q
I
M
K
K
L
-
K
H
P
N
L
V
Q
L
Y
G
V
-
C
-
T
-
K
E
P
---
P
-
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
C
E
------
G
-
H
T
V
-
N
A
Q
A
L
L
D
M
-
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
V
K
V
A
D
F
G
L
A
R
L
I
------------
A
K
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
---------
Y
P
G
M
S
G
---
S
E
----
V
I
E
Q
V
E
--
R
-
G
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
415
Blastp_CBE
53.78
41%
-38
- C5 -
-
2HZI
10.3
-
ABL1_HUMAN
B:
[18-266]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
-----
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
399
Blastp_CBE
53.75
41%
-29
- C5 -
-
1IEP
10.7
-
ABL1_MOUSE
B:
[19-267]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
-
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
345
Blastp_CBE
53.75
41%
-28
- C5 -
-
2HYY
10.4
-
ABL1_HUMAN
D:
[14-262]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
---
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
541
HHSearch
53.67
34%
-19
- C5 -
-
5FM3
5.6
-
A:
[59-351]
-----------------------------------------------------------------------------------------------------------------------
W
E
----
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
K
GR-
A
G
Y
T
T
--
V
-
A
V
K
M
L
K
E
-
N
A
--
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
-
C
-
S
-
Q
-
D
---
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
---------
A
L
T
-
M
G
-
D
L
I
S
F
-
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
Y
-
V
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
G
G
N
P
---------
Y
P
G
I
P
P
---
E
R
----
L
F
N
L
L
K
--
T
-
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
--
A
D
I
S
K
D
L
E
K
M
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
373
Blastp_CBE
53.66
41%
-31
- C5 -
-
6BL8
7.2
-
ABL1_HUMAN
A:
[9-257]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
-
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
F
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
P
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
519
Blastp_CBE
53.61
41%
23
- C5 -
-
4BBF
7.8
-
D:
[10-286]
-------------------------------------------------------------------------------------------------------------------------------
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
---
D
N
T
G
E
--
V
V
A
V
K
K
L
Q
H
----
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
-
Q
H
D
N
I
V
K
Y
K
G
V
-
C
-
Y
-
S
-
A
GRR
N
-
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
------
E
-
R
I
D
-
H
I
-
K
L
L
Q
Y
-
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
N
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
KSPPAEFMR
M
I
G
-
N
D
---
K
Q
GQMI
V
F
H
L
I
E
LL
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
RD
L
A
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
414
Blastp_CBE
53.63
41%
-26
- C5 -
-
3CS9
12.0
-
ABL1_HUMAN
A:
[18-266]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
-----
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
334
Blastp_CBE
53.62
41%
-31
- C5 -
-
6NPE
10.5
-
ABL1_HUMAN
A:
[27-275]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
----------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
368
Blastp_CBE
53.61
41%
-36
- C5 -
-
2QOH
8.1
-
ABL1_MOUSE
A:
[14-262]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
----
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
438
Blastp_CBE
53.58
41%
-28
- C5 -
-
3QRJ
9.5
-
ABL1_HUMAN
B:
[19-267]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
-
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
522
Blastp_CBE
53.49
41%
21
- C5 -
-
4BBF
7.8
-
JAK2_HUMAN
A:
[10-286]
-------------------------------------------------------------------------------------------------------------------------------
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
---
D
N
T
G
E
--
V
V
A
V
K
K
L
Q
H
----
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
-
Q
H
D
N
I
V
K
Y
K
G
V
-
C
-
Y
-
S
-
A
GRR
N
-
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
------
E
-
R
I
D
-
H
I
-
K
L
L
Q
Y
-
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
N
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
KSPPAEFMR
M
I
G
-
N
D
---
K
Q
GQMI
V
F
H
L
I
E
LL
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
RD
L
A
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
486
Blastp_CBE
53.43
41%
-61
- C5 -
-
3UQG
4.1
-
SRC_CHICK
B:
[18-269]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
R
L
E
V
K
L
G
Q
----
E
V
W
M
G
T
W
N
G
-------
T
T
R
--
V
-
A
I
K
T
L
K
-----
S
-
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
-
E
-
E
---
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
------
G
-
K
Y
L
R
L
P
-
Q
L
V
D
M
-
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
---------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
---------
Y
P
G
M
V
N
---
R
E
----
V
L
D
Q
V
E
--
R
-
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
--
E
Y
L
Q
A
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
411
Blastp_CBE
53.41
41%
-30
- C5 -
-
3CS9
11.1
-
ABL1_HUMAN
D:
[18-266]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-----------
T
--
V
-
A
V
K
T
L
K
E
-
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
323
Blastp_CBE
53.36
43%
-37
- C5 -
-
4XLI
7.1
-
B:
[9-254]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
----
G
E
V
Y
V
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
-
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
L
-
E
-
P
---
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
S
------
R
-
E
E
V
-
T
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
D
L
L
E
--
K
-
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
319
Blastp_CBE
53.35
43%
-38
- C5 -
-
2XYN
4.3
-
ABL2_HUMAN
B:
[33-278]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
---
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
L
-
E
-
P
---
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
E
E
V
-
T
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
D
L
L
E
--
K
-
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
403
Blastp_CBE
53.28
41%
-34
- C5 -
-
3DK3
8.5
-
ABL1_MOUSE
B:
[12-260]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
-----
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
F
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
P
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
520
Blastp_CBE
53.23
41%
19
- C5 -
-
4BBF
7.6
-
JAK2_HUMAN
C:
[10-286]
-------------------------------------------------------------------------------------------------------------------------------
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
---
D
N
T
G
E
--
V
V
A
V
K
K
L
Q
H
----
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
-
Q
H
D
N
I
V
K
Y
K
G
V
-
C
-
Y
-
S
-
A
GRR
N
-
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
------
E
-
R
I
D
-
H
I
-
K
L
L
Q
Y
-
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
N
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
KSPPAEFMR
M
I
G
-
N
D
---
K
Q
GQMI
V
F
H
L
I
E
LL
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
RD
L
A
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
348
Blastp_CBE
53.25
41%
-26
- C5 -
-
2HYY
10.3
-
ABL1_HUMAN
A:
[14-262]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
--
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
426
Blastp_CBE
53.23
41%
-29
- C5 -
-
2G2I
3.8
-
ABL1_HUMAN
A:
[16-264]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
---
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
-
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
346
Blastp_CBE
53.16
41%
-31
- C5 -
-
2HYY
10.9
-
ABL1_HUMAN
C:
[14-262]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
--
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-----
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
526
Blastp_CBE
53.13
41%
16
- C5 -
-
4BBE
7.6
-
JAK2_HUMAN
A:
[10-286]
-------------------------------------------------------------------------------------------------------------------------------
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
---
D
N
T
G
E
--
V
V
A
V
K
K
L
Q
H
----
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
-
Q
H
D
N
I
V
K
Y
K
G
V
-
C
-
Y
-
S
-
A
GRR
N
-
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
------
E
-
R
I
D
-
H
I
-
K
L
L
Q
Y
-
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
N
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
KSPPAEFMR
M
I
G
-
N
D
---
K
Q
GQMI
V
F
H
L
I
E
LL
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
RD
L
A
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
312
Blastp_CBE
53.08
40%
-30
- C5 -
-
3RCD
8.3
-
ERBB2_HUMAN
C:
[9-279]
--------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
----
L
K
E
T
E
L
R
K
V
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
-
I
P
D
---
G
E
N
V
K
IP
V
-
A
I
K
V
L
R
-------
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
G
V
-
G
S
P
Y
V
S
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
V
T
Q
L
M
P
Y
G
C
L
L
D
H
V
R
E
N
R
------
G
-
R
L
G
-
S
Q
-
D
L
L
N
W
-
C
M
Q
I
A
K
G
M
S
Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
------------------
V
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
K
P
---------
Y
D
G
I
P
A
---
R
E
----
I
P
D
L
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
S
E
C
R
P
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
340
Blastp_CBE
53.05
41%
-27
- C5 -
-
4ZOG
7.4
-
ABL1_HUMAN
B:
[13-261]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
-
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
--
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
388
Blastp_CBE
52.88
41%
-30
- C5 -
-
3MSS
11.0
-
ABL1_MOUSE
B:
[19-267]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
-----------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
---
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
386
Blastp_CBE
52.88
41%
-29
- C5 -
-
3MSS
10.9
-
ABL1_MOUSE
D:
[19-267]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
-----------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
---
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
521
Blastp_CBE
52.85
41%
23
- C5 -
-
4BBF
7.8
-
JAK2_HUMAN
B:
[10-286]
-------------------------------------------------------------------------------------------------------------------------------
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
---
D
N
T
G
E
--
V
V
A
V
K
K
L
Q
H
----
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
-
Q
H
D
N
I
V
K
Y
K
G
V
-
C
-
Y
-
S
-
A
GRR
N
-
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
------
E
-
R
I
D
-
H
I
-
K
L
L
Q
Y
-
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
N
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
KSPPAEFMR
M
I
G
-
N
D
---
K
Q
GQMI
V
F
H
L
I
E
LL
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
RD
L
A
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
389
Blastp_CBE
52.84
41%
-33
- C5 -
-
3MSS
11.2
-
ABL1_MOUSE
A:
[19-267]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
-----------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
---
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
387
Blastp_CBE
52.83
41%
-33
- C5 -
-
3MSS
11.0
-
ABL1_MOUSE
C:
[19-267]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
-----------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
---
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
425
Blastp_CBE
52.77
41%
-36
- C5 -
-
2G2I
3.4
-
ABL1_HUMAN
B:
[16-264]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
----
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
-
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
343
Blastp_CBE
52.71
41%
-32
- C5 -
-
2HZ4
7.8
-
ABL1_HUMAN
B:
[14-262]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
-----
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
-
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
353
Blastp_CBE
52.67
41%
-25
- C5 -
-
2HIW
9.3
-
ABL1_HUMAN
B:
[16-264]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
-
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
367
Blastp_CBE
52.66
41%
-32
- C5 -
-
2QOH
8.2
-
ABL1_MOUSE
B:
[14-262]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
----
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
401
Blastp_CBE
52.62
41%
-30
- C5 -
-
1FPU
7.1
-
ABL1_MOUSE
B:
[19-267]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
-
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-------
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
316
Blastp_CBE
52.60
43%
-32
- C5 -
-
3HMI
6.8
-
A:
[33-278]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
-
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
L
-
E
-
P
---
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
E
E
V
-
T
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
D
L
L
E
--
K
-
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
391
Blastp_CBE
52.56
41%
-33
- C5 -
-
3MS9
11.0
-
ABL1_MOUSE
A:
[19-267]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
-----------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
----
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
524
Blastp_CBE
52.49
41%
22
- C5 -
-
4BBE
6.9
-
JAK2_HUMAN
C:
[10-286]
-------------------------------------------------------------------------------------------------------------------------------
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
---
D
N
T
G
E
--
V
V
A
V
K
K
L
Q
H
----
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
-
Q
H
D
N
I
V
K
Y
K
G
V
-
C
-
Y
-
S
-
A
GRR
N
-
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
------
E
-
R
I
D
-
H
I
-
K
L
L
Q
Y
-
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
N
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
KSPPAEFMR
M
I
G
-
N
D
---
K
Q
GQMI
V
F
H
L
I
E
LL
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
RD
L
A
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
384
Blastp_CBE
52.49
41%
-31
- C5 -
-
6HD4
11.1
-
ABL1_MOUSE
B:
[19-267]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
----
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
392
Blastp_CBE
52.43
41%
-31
- C5 -
-
3K5V
10.8
-
ABL1_MOUSE
B:
[19-267]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
----
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
382
Blastp_CBE
52.43
41%
-30
- C5 -
-
6HD6
10.7
-
ABL1_MOUSE
B:
[19-267]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
----
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
317
Blastp_CBE
52.42
43%
-25
- C5 -
-
3GVU
11.1
-
A:
[33-278]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
-
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
L
-
E
-
P
---
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
E
E
V
-
T
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
-----
G
D
T
Y
T
----
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
D
L
L
E
--
K
-
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
418
Blastp_CBE
52.41
41%
-36
- C5 -
-
2E2B
11.1
-
ABL1_HUMAN
A:
[19-267]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
-----
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
------
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
320
Blastp_CBE
52.33
43%
-39
- C5 -
-
2XYN
7.3
-
ABL2_HUMAN
A:
[33-278]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
---
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
L
-
E
-
P
---
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
E
E
V
-
T
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
D
L
L
E
--
K
-
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
509
Blastp_CBE
52.20
41%
23
- C5 -
-
6BBV
6.6
-
A:
[12-288]
-------------------------------------------------------------------------------------------------------------------------------
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
---
D
N
T
G
E
--
V
V
A
V
K
K
L
Q
H
----
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
-
Q
H
D
N
I
V
K
Y
K
G
V
-
C
-
Y
-
S
-
A
GRR
N
-
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
------
E
-
R
I
D
-
H
I
-
K
L
L
Q
Y
-
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
KSPPAEFMR
M
I
G
N
D
K
QGQ
S
I
----
V
T
H
L
I
E
LL
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
RD
L
A
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
313
Blastp_CBE
52.11
40%
-29
- C5 -
-
3RCD
8.6
-
ERBB2_HUMAN
A:
[9-279]
--------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
----
L
K
E
T
E
L
R
K
V
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
-
I
P
D
---
G
E
N
V
K
IP
V
-
A
I
K
V
L
R
-------
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
G
V
-
G
S
P
Y
V
S
R
L
L
G
I
-
C
-
L
-
T
-
S
---
T
-
V
Q
L
V
T
Q
L
M
P
Y
G
C
L
L
D
H
V
R
E
N
R
------
G
-
R
L
G
-
S
Q
-
D
L
L
N
W
-
C
M
Q
I
A
K
G
M
S
Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
------------------
V
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
K
P
---------
Y
D
G
I
P
A
---
R
E
----
I
P
D
L
L
E
--
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
S
E
C
R
P
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
417
Blastp_CBE
52.10
41%
-34
- C5 -
-
2E2B
11.7
-
ABL1_HUMAN
B:
[19-267]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
------
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
--------
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
394
Blastp_CBE
52.07
41%
-29
- C5 -
-
2HZN
6.6
-
ABL1_MOUSE
A:
[19-267]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
---
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
---
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
523
Blastp_CBE
51.90
41%
16
- C5 -
-
4BBE
7.1
-
D:
[10-286]
-------------------------------------------------------------------------------------------------------------------------------
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
---
D
N
T
G
E
--
V
V
A
V
K
K
L
Q
H
----
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
-
Q
H
D
N
I
V
K
Y
K
G
V
-
C
-
Y
-
S
-
A
GRR
N
-
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
------
E
-
R
I
D
-
H
I
-
K
L
L
Q
Y
-
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
N
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
KSPPAEFMR
M
I
G
-
N
D
---
K
Q
GQMI
V
F
H
L
I
E
LL
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
RD
L
A
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
510
Blastp_CBE
51.90
41%
23
- C5 -
-
5TQ8
9.6
-
A:
[12-288]
-------------------------------------------------------------------------------------------------------------------------------
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
---
D
N
T
G
E
--
V
V
A
V
K
K
L
Q
H
----
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
-
Q
H
D
N
I
V
K
Y
K
G
V
-
C
-
Y
-
S
-
A
GRR
N
-
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
------
E
-
R
I
D
-
H
I
-
K
L
L
Q
Y
-
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
KSPPAEFMR
M
I
G
N
D
K
QGQ
S
I
----
V
T
H
L
I
E
LL
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
RD
L
A
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
349
Blastp_CBE
51.87
41%
-34
- C5 -
-
4YC8
3.4
-
ABL1_HUMAN
B:
[16-264]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
------
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
-
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
318
Blastp_CBE
51.87
43%
-37
- C5 -
-
2XYN
5.5
-
C:
[33-278]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
---
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
L
-
E
-
P
---
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
E
E
V
-
T
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
D
L
L
E
--
K
-
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
511
Blastp_CBE
51.69
41%
24
- C5 -
-
5TQ5
8.0
-
A:
[12-288]
-------------------------------------------------------------------------------------------------------------------------------
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
---
D
N
T
G
E
--
V
V
A
V
K
K
L
Q
H
----
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
-
Q
H
D
N
I
V
K
Y
K
G
V
-
C
-
Y
-
S
-
A
GRR
N
-
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
------
E
-
R
I
D
-
H
I
-
K
L
L
Q
Y
-
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
KSPPAEFMR
M
I
G
N
D
K
QGQ
S
I
----
V
T
H
L
I
E
LL
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
RD
L
A
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
497
Blastp_CBE
51.49
41%
-74
- C5 -
-
3EN6
5.8
-
SRC_CHICK
B:
[18-269]
--------------------------------------------------------------------------------------------------------------------------------
E
S
L
R
L
E
V
K
L
G
Q
--
F
G
E
V
W
M
G
T
W
N
G
-------
T
T
R
--
V
-
A
I
K
T
L
------------------
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
-
S
---------
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
------
G
-
K
Y
L
R
L
P
-
Q
L
V
D
M
-
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
----------------------
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
---------
Y
P
G
M
V
N
---
R
E
----
V
L
D
Q
V
E
--
R
-
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
--
E
Y
L
Q
A
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
359
Blastp_CBE
51.45
41%
-30
- C5 -
-
3OXZ
11.7
-
ABL1_MOUSE
A:
[14-262]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
-----------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
------------
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
362
Blastp_CBE
51.39
41%
-28
- C5 -
-
5HU9
11.4
-
ABL1_HUMAN
A:
[18-266]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
-
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-----------
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
525
Blastp_CBE
51.34
41%
23
- C5 -
-
4BBE
6.5
-
JAK2_HUMAN
B:
[10-286]
-------------------------------------------------------------------------------------------------------------------------------
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
L
Q
---
D
N
T
G
E
--
V
V
A
V
K
K
L
Q
H
----
S
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
-
Q
H
D
N
I
V
K
Y
K
G
V
-
C
-
Y
-
S
-
A
GRR
N
-
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
------
E
-
R
I
D
-
H
I
-
K
L
L
Q
Y
-
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
N
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
KSPPAEFMR
M
I
G
-
N
D
---
K
Q
GQMI
V
F
H
L
I
E
LL
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
RD
L
A
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
372
Blastp_CBE
51.11
41%
-31
- C5 -
-
6BL8
6.2
-
ABL1_HUMAN
B:
[9-257]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
---
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
-
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
F
T
A
H
-
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
P
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
440
Blastp_CBE
51.08
41%
-35
- C5 -
-
4XEY
7.6
-
ABL1_HUMAN
B:
[126-374]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
------
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
----
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
429
Blastp_CBE
51.04
41%
-24
- C5 -
-
2G2F
3.6
-
ABL1_HUMAN
B:
[16-264]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
-----
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
E
-
D
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
350
Blastp_CBE
50.85
41%
-34
- C5 -
-
4YC8
3.1
-
ABL1_HUMAN
A:
[16-264]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
------
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
-----
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
324
Blastp_CBE
50.65
43%
-38
- C5 -
-
4XLI
7.9
-
ABL2_MOUSE
A:
[9-254]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
K
-----
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
L
-
E
-
P
---
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
S
------
R
-
E
E
V
-
T
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
D
L
L
E
--
K
-
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
412
Blastp_CBE
50.53
41%
-28
- C5 -
-
3CS9
11.6
-
ABL1_HUMAN
C:
[18-266]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
------
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
--------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
413
Blastp_CBE
50.42
41%
-21
- C5 -
-
3CS9
11.7
-
ABL1_HUMAN
B:
[18-266]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
----
T
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
--------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
333
Blastp_CBE
50.36
41%
-29
- C5 -
-
6NPE
10.4
-
ABL1_HUMAN
B:
[27-275]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
-----------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
-------------------
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
331
Blastp_CBE
49.85
41%
-28
- C5 -
-
6NPU
10.9
-
ABL1_HUMAN
B:
[27-275]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
-----------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
-----------------
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
329
Blastp_CBE
49.38
41%
-26
- C5 -
-
6NPV
11.0
-
ABL1_HUMAN
B:
[27-275]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
-----------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
-----------------
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
559
Fugue
49.27
31%
6
- C5 -
-
3CD3
8.2
-
A:
[1-376]
----------------------------------
S
M
I
P
E
V
Q
K
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
E
L
L
V
H
S
G
D
F
L
V
R
E
S
Q
E
Y
V
L
S
V
P
R
H
F
I
I
N
L
Y
R
L
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
P
L
S
G
V
V
L
H
R
A
V
P
K
DKWV
L
N
H
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
---
R
---
A
D
N
T
L
--
V
-
A
V
K
S
C
R
P
-------
D
L
K
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
H
P
N
I
V
R
L
I
G
V
-
C
T
Q
-
K
-
Q
---
P
-
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
G
------
A
-
R
L
R
-
V
K
-
T
L
L
Q
M
-
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
--
D
G
V
A
A
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
---------
Y
P
N
L
S
N
---
Q
Q
----
T
R
E
F
V
E
--
K
-
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
--
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
361
Blastp_CBE
48.96
41%
-22
- C5 -
-
4WA9
4.8
-
ABL1_HUMAN
A:
[15-263]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
-------------------------
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
-------
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
--
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
327
Blastp_CBE
48.92
41%
-33
- C5 -
-
2HZ0
9.5
-
ABL1_HUMAN
B:
[14-262]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
------
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
-----
M
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
335
Blastp_CBE
48.90
41%
-23
- C5 -
-
3PYY
10.8
-
ABL1_HUMAN
B:
[27-275]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
-----------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
-----------------
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
L
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
459
Blastp_CBE
46.72
41%
-45
- C5 -
-
3DK6
7.3
-
ABL1_MOUSE
A:
[12-260]
---------------------------------------------------------------------------------------------------------------------------------
D
I
T
M
K
H
K
L
--
G
Q
F
G
E
V
Y
E
G
V
W
K
K
Y
S
------
L
T
--
V
-
A
V
K
T
L
------
E
----
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
-
T
R
E
-
P
---
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------
R
-
Q
E
V
-
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
T
A
H
A
---
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
---------
Y
P
G
I
D
P
---
S
Q
----
V
Y
E
L
L
E
--
K
D
-
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
--
A
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------