@TOME V3
(Feb 2022)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Screening
Virtual Screening Score
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ACV1C_HUMAN: (2020-09-04 )
MTRALCSALRQALLLLAAAAELSPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPTASPNAPKLGPMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTASGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQLCVKEDCKA
Atome Classification :
(83 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190......--.200.......210....--...220......----.230.........240.......250......--.260.......270.......280.----......290.......300.......310--.--...--...--.320.......330.......340.......350.......360.......370.......380.......390.......400...-.---..-.410.......420.......430.......440......-.450.......460.......470.......480...-----....490.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(pKd)
(pKd)
(Uniprot)
M
T
R
A
L
C
S
A
L
R
Q
A
L
L
L
L
A
A
A
A
ELSPG
L
K
C
V
C
L
L
CDSSN
F
T
CQTEG
A
C
W
A
S
V
M
LTN
G
K
E
Q
V
I
K
S
C
VSLPEL
N
A
Q
V
F
C
HSSNNVT
K
T
E
C
C
F
T
D
FCN
N
I
T
L
HLPTASPNAPKLG
P
M
E
L
A
I
I
I
T
V
P
V
C
L
L
S
I
A
A
M
L
T
V
W
ACQGRQCSYRKKKRP
N
V
E
E
P
L
S
ECNLVNA
G
K
T
L
K
D
L
I
Y
D
VTASGSGSG
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
--
E
I
VGKGRFGEVWHGRWCG--E
D
V
A
V
K
IFSSR
D
----
E
R
--
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
RHE
N
I
L
G
F
I
AADNK--DNG
T
W
T
Q
L
W
L
V
S
E
Y
HEQG
S
L
Y
D
Y
L
N----R
N
I
V
T
V
A
G
M
I
K
L
A
L
S
I
A
S
G
L
A
H
L
H
M
E
I
V---G--TQG--KPA--IAHRDIKSK
N
I
L
V
K
KCET
C
A
I
ADL
G
L
A
V
KHDSI
L
N
TIDIPQNPKVGTKRYM
A
P
E
M
L
DDTMN
V
N
I
F
E
S
F
K
RAD
I
Y
S
V
G
L
V
Y
W
E
I
A
R
RC-S---VG-G
I
V
E
E
YQLP
Y
Y
DMVPSDP
S
I
E
E
M
R
K
V
V
CDQKFRPSIP
N
Q
W
-
Q
S
C
E
A
L
R
V
M
G
R
I
M
R
E
C
WYANG
A
A
R
L
T
A
L
R
I
K
K
T
I
S
Q
L
-----
C
V
K
E
DCKA
23
Blastp_CBE
95.90
81%
-112
- C2 -
-
3KCF
-
-
TGFR1_HUMAN
C:
[10-339]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
G
T
T
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
--
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
V
A
V
K
I
F
S
S
R
E
----
E
R
--
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
--
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
-
S
---
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
-
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
-----
S
Q
Q
E
G
---
22
Blastp_CBE
95.83
81%
-111
- C2 -
-
3KCF
-
-
TGFR1_HUMAN
D:
[10-339]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
G
T
T
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
--
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
V
A
V
K
I
F
S
S
R
E
----
E
R
--
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
--
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
-
S
---
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
-
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
-----
S
Q
Q
E
G
---
32
Blastp_CBE
95.62
81%
-107
- C2 -
-
2X7O
-
-
TGFR1_HUMAN
B:
[10-339]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
G
T
T
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
--
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
V
A
V
K
I
F
S
S
R
E
----
E
R
--
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
--
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
-
S
---
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
-
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
-----
S
Q
Q
E
G
---
31
Blastp_CBE
95.46
81%
-105
- C2 -
-
2X7O
-
-
TGFR1_HUMAN
C:
[10-339]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
G
T
T
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
--
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
V
A
V
K
I
F
S
S
R
E
----
E
R
--
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
--
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
-
S
---
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
-
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
-----
S
Q
Q
E
G
---
25
Blastp_CBE
95.28
81%
-112
- C2 -
-
3FAA
-
-
TGFR1_HUMAN
E:
[10-339]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
G
T
T
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
--
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
V
A
V
K
I
F
S
S
R
E
----
E
R
--
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
--
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
-
S
---
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
-
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
-----
S
Q
Q
E
G
---
27
Blastp_CBE
95.17
81%
-119
- C2 -
-
3FAA
-
-
TGFR1_HUMAN
C:
[10-339]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
G
T
T
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
--
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
V
A
V
K
I
F
S
S
R
E
----
E
R
--
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
--
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
-
S
---
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
-
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
-----
S
Q
Q
E
G
---
28
Blastp_CBE
94.91
81%
-116
- C2 -
-
3FAA
-
-
TGFR1_HUMAN
B:
[10-340]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
G
T
T
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
--
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
V
A
V
K
I
F
S
S
R
E
----
E
R
--
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
--
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---------
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
---
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
-
S
---
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
-
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
-----
S
Q
Q
E
G
I
--
30
Blastp_CBE
94.84
81%
-108
- C2 -
-
2X7O
-
-
TGFR1_HUMAN
D:
[10-339]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
G
T
T
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
--
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
V
A
V
K
I
F
S
S
R
E
----
E
R
--
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
--
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
-
S
---
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
-
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
-----
S
Q
Q
E
G
---
21
Blastp_CBE
94.73
81%
-106
- C2 -
-
3KCF
-
-
TGFR1_HUMAN
E:
[10-339]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
G
T
T
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
--
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
V
A
V
K
I
F
S
S
R
E
----
E
R
--
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
--
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
-
S
---
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
-
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
-----
S
Q
Q
E
G
---
3
PsiBlast_PDB
94.56
80%
-114
- C2 -
-
3FAA
-
-
TGFR1_HUMAN
A:
[10-339]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
G
T
T
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
--
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
V
A
V
K
I
F
S
S
R
E
----
E
R
--
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
--
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
--
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
-
S
---
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
-
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
-----
S
Q
Q
E
G
---
29
Blastp_CBE
94.51
81%
-107
- C2 -
-
2X7O
-
-
TGFR1_HUMAN
E:
[10-339]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
G
T
T
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
--
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
V
A
V
K
I
F
S
S
R
E
----
E
R
--
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
--
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
-
S
---
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
-
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
-----
S
Q
Q
E
G
---
24
Blastp_CBE
94.50
81%
-110
- C2 -
-
3KCF
-
-
TGFR1_HUMAN
B:
[10-340]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
G
T
T
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
--
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
V
A
V
K
I
F
S
S
R
E
----
E
R
--
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
--
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---------
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
---
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
-
S
---
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
-
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
-----
S
Q
Q
E
G
I
--
26
Blastp_CBE
94.25
81%
-109
- C2 -
-
3FAA
-
-
TGFR1_HUMAN
D:
[10-339]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
G
T
T
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
--
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
V
A
V
K
I
F
S
S
R
E
----
E
R
--
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
--
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
-
S
---
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
-
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
-----
S
Q
Q
E
G
---
2
PsiBlast_PDB
94.18
80%
-107
- C2 -
-
1IAS
-
-
TGFR1_HUMAN
A:
[10-339]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
G
T
T
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
--
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
V
A
V
K
I
F
S
S
R
E
----
E
R
--
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
--
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
-
S
---
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
-
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
-----
S
Q
Q
E
G
---
4
PsiBlast_PDB
94.02
80%
-112
- C2 -
-
3KCF
-
-
TGFR1_HUMAN
A:
[10-339]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
G
T
T
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
--
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
V
A
V
K
I
F
S
S
R
E
----
E
R
--
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
--
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
--
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
-
S
---
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
-
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
-----
S
Q
Q
E
G
---
5
PsiBlast_PDB
93.93
80%
-107
- C2 -
-
2X7O
-
-
TGFR1_HUMAN
A:
[10-339]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
G
T
T
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
--
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
V
A
V
K
I
F
S
S
R
E
----
E
R
--
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
--
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
-
S
---
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
-
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
-----
S
Q
Q
E
G
---
253
HHSearch
93.31
83%
-109
- C2 -
-
3FAA
-
-
TGFR1_HUMAN
E:
[19-339]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
--
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
V
A
V
K
I
F
S
S
R
E
----
E
R
--
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
--
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
-
S
---
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
-
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
-----
S
Q
Q
E
G
---
50
Blastp_CBE
93.02
81%
-120
- C2 -
-
5E8X
-
-
TGFR1_HUMAN
A:
[4-306]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
D
I
V
L
Q
--
E
S
V
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
V
A
V
K
I
F
S
S
R
E
----
E
R
--
S
W
F
R
E
A
E
I
F
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
--
D
N
G
T
W
T
Q
L
W
L
V
T
D
F
H
E
H
G
N
L
F
D
Y
L
N
----
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
C
D
F
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
-
S
---
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
-
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
-----
S
Q
Q
E
G
I
K
-
252
HHSearch
92.54
84%
-104
- C2 -
-
1B6C
-
-
TGFR1_HUMAN
B:
[16-339]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
--
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
V
A
V
K
I
F
S
S
R
E
----
E
R
--
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
--
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
-
S
---
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
-
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
-----
S
Q
Q
E
G
---
1
PsiBlast_PDB
92.50
80%
-103
- C2 -
-
1B6C
-
-
TGFR1_HUMAN
B:
[14-339]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
--
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
V
A
V
K
I
F
S
S
R
E
----
E
R
--
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
--
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
-
S
---
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
-
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
-----
S
Q
Q
E
G
---
254
HHSearch
91.66
81%
-119
- C2 -
-
5E8X
8.6
-
TGFR1_HUMAN
A:
[5-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
R
D
I
V
L
Q
--
E
S
V
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
V
A
V
K
I
F
S
S
R
E
----
E
R
--
S
W
F
R
E
A
E
I
F
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
--
D
N
G
T
W
T
Q
L
W
L
V
T
D
F
H
E
H
G
N
L
F
D
Y
L
N
----
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
C
D
F
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
-
S
---
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
-
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
-----
S
Q
Q
E
G
---
256
HHSearch
89.35
83%
-113
- C2 -
-
5USQ
8.9
-
TGFR1_HUMAN
A:
[3-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
T
I
V
L
Q
--
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
V
A
V
K
I
F
S
S
R
E
----
E
R
--
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
--
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
-
S
---
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
-
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
-----
S
Q
------
255
HHSearch
89.01
83%
-107
- C2 -
-
4X2J
5.5
-
TGFR1_HUMAN
A:
[3-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
R
T
I
V
L
Q
--
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
V
A
V
K
I
F
S
S
R
E
----
E
R
--
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
--
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
-
S
---
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
-
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
-----
S
Q
Q
E
G
---
57
Blastp_CBE
85.70
64%
-114
- C2 -
-
3H9R
1.7
-
ACVR1_HUMAN
A:
[10-329]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
L
L
D
H
S
C
T
S
G
S
G
S
G
L
P
F
L
V
Q
R
T
V
A
R
Q
I
T
L
L
--
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
----
E
K
--
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
-----
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
-------------
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
-
V
---
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
-
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------
55
Blastp_CBE
85.67
64%
-108
- C2 -
-
6I1S
3.5
-
ACVR1_HUMAN (first)
A:
[10-329]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
A
D
L
L
D
H
-----
S
G
S
G
L
P
F
L
V
Q
R
T
V
A
R
Q
I
T
L
L
--
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
----
E
K
--
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
-----
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
-
V
---
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
-
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------
87
Blastp_CBE
83.47
64%
-108
- C2 -
-
3Q4U
8.7
-
ACVR1_HUMAN
B:
[2-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
Q
R
T
V
A
R
D
I
T
L
L
--
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
----
E
K
--
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
--
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
-
V
---
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
-
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------
78
Blastp_CBE
83.47
64%
-101
- C2 -
-
5OXG
8.4
-
ACVR1_HUMAN
C:
[2-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
Q
R
T
V
A
R
D
I
T
L
L
--
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
----
E
K
--
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
--
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
-
V
---
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
-
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------
54
Blastp_CBE
83.27
63%
-100
- C2 -
-
6EIX
2.1
-
ACVR1_HUMAN
A:
[23-334]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
S
G
L
P
F
L
V
Q
R
T
V
A
R
E
I
T
L
L
--
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
----
E
K
--
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
--
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
-
V
---
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
-
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
DNSLD--------
63
Blastp_CBE
83.26
64%
-105
- C2 -
-
6T6D
7.0
-
?
B:
[5-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
--
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
----
E
K
--
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
--
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
-
V
---
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
-
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------
79
Blastp_CBE
83.21
64%
-102
- C2 -
-
5OXG
8.1
-
ACVR1_HUMAN
B:
[5-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
--
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
----
E
K
--
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
--
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
-
V
---
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
-
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------
71
Blastp_CBE
83.20
64%
-107
- C2 -
-
6GIN
8.7
-
ACVR1_HUMAN
A:
[6-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
--
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
----
E
K
--
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
--
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
-
V
---
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
-
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------
93
Blastp_CBE
83.09
63%
-106
- C2 -
-
6ACR
7.1
-
ACVR1_HUMAN
A:
[5-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
H
Q
I
T
L
L
--
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
----
E
K
--
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
--
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
---
G
----
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
-
V
---
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
-
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------
64
Blastp_CBE
83.09
64%
-112
- C2 -
-
6T6D
7.4
-
?
A:
[6-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
--
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
----
E
K
--
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
--
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
-
L
D
V
---
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
-
V
---
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
-
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------
257
HHSearch
83.03
64%
-106
- C2 -
-
3MDY
4.6
-
BMR1B_HUMAN
A:
[27-334]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
L
V
Q
R
T
I
A
K
Q
I
Q
M
V
--
K
Q
I
G
K
G
R
Y
G
E
V
W
M
G
K
W
R
G
--
E
K
V
A
V
K
V
F
F
T
T
E
----
E
A
--
S
W
F
R
E
T
E
I
Y
Q
T
V
L
M
R
H
E
N
I
L
G
F
I
A
A
D
I
K
--
G
T
G
S
W
T
Q
L
Y
L
I
T
D
Y
H
E
N
G
S
L
Y
D
Y
L
K
----
S
T
T
L
D
A
K
S
M
L
K
L
A
Y
S
S
V
S
G
L
C
H
L
H
T
E
I
F
---
S
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
K
F
I
---------
P
N
T
R
V
G
T
K
R
Y
M
P
P
E
V
L
D
E
S
L
N
R
N
H
F
Q
S
Y
I
M
A
D
M
Y
S
F
G
L
I
L
W
E
V
A
R
R
C
-
V
---
S
G
-
G
I
V
E
E
Y
Q
L
P
Y
H
D
L
V
P
S
D
P
S
Y
E
D
M
R
E
I
V
C
I
K
K
L
R
P
S
F
P
N
R
W
-
S
S
D
E
C
L
R
Q
M
G
K
L
M
T
E
C
W
A
H
N
P
A
S
R
L
T
A
L
R
V
K
K
T
L
A
K
M
-----
S
E
S
Q
D
---
80
Blastp_CBE
82.83
64%
-104
- C2 -
-
5OXG
8.4
-
ACVR1_HUMAN
A:
[5-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
--
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
----
E
K
--
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
--
S
---
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
-
V
---
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
-
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------
88
Blastp_CBE
82.73
64%
-104
- C2 -
-
3Q4U
8.5
-
ACVR1_HUMAN
A:
[4-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
V
A
R
D
I
T
L
L
--
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
----
E
K
--
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
--
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
-
V
---
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
-
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------
61
Blastp_CBE
82.68
64%
-107
- C2 -
-
6T6D
5.7
-
?
D:
[5-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
--
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
----
E
K
--
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
--
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
-----------
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
-
V
---
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
-
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------
258
HHSearch
82.67
64%
-101
- C2 -
-
5OXG
8.4
-
ACVR1_HUMAN
C:
[5-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
--
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
----
E
K
--
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
--
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
-
V
---
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
-
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------
89
Blastp_CBE
82.67
64%
-105
- C2 -
-
3OOM
7.4
-
ACVR1_HUMAN
A:
[5-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
--
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
----
E
K
--
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
--
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
-
V
---
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
-
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------
73
Blastp_CBE
82.66
64%
-105
- C2 -
-
5OY6
6.8
-
ACVR1_HUMAN
D:
[6-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
--
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
----
E
K
--
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
--
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
----
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
-
V
---
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
-
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------
84
Blastp_CBE
82.46
64%
-103
- C2 -
-
4BGG
8.0
-
ACVR1_HUMAN
A:
[5-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
--
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
----
E
K
--
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
--
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
-
V
---
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
-
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------
74
Blastp_CBE
82.39
64%
-105
- C2 -
-
5OY6
7.0
-
ACVR1_HUMAN
C:
[6-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
--
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
----
E
K
--
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
--
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
----
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
-
V
---
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
-
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------
60
Blastp_CBE
82.35
64%
-106
- C2 -
-
6T8N
8.4
-
?
A:
[5-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
--
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
----
E
K
--
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
--
S
---
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
-
V
---
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
-
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------
72
Blastp_CBE
82.33
64%
-108
- C2 -
-
6GI6
6.7
-
ACVR1_HUMAN
A:
[4-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
V
A
R
D
I
T
L
L
--
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
----
E
K
--
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
--
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
-
V
---
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
-
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------
75
Blastp_CBE
82.21
64%
-108
- C2 -
-
5OY6
6.8
-
ACVR1_HUMAN
B:
[5-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
--
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
----
E
K
--
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
--
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
----
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
-
V
---
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
-
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------
91
Blastp_CBE
82.16
64%
-105
- C2 -
-
3MTF
7.3
-
ACVR1_HUMAN
A:
[5-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
--
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
----
E
K
--
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
--
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
-
V
---
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
-
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------
67
Blastp_CBE
82.13
64%
-108
- C2 -
-
6SRH
7.9
-
ACVR1_HUMAN
B:
[7-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
D
I
T
L
L
--
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
----
E
K
--
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
--
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
-
V
---
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
-
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------
59
Blastp_CBE
82.08
64%
-104
- C2 -
-
6T8N
8.8
-
?
B:
[5-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
--
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
----
E
K
--
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
--
S
----
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
-
V
---
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
-
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------
66
Blastp_CBE
81.99
64%
-113
- C2 -
-
6SZM
7.6
-
?
A:
[4-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
V
A
R
D
I
T
L
L
--
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
----
E
K
--
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
--
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
----------
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
-
V
---
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
-
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------
70
Blastp_CBE
81.91
64%
-106
- C2 -
-
6GIN
8.4
-
ACVR1_HUMAN
B:
[6-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
--
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
----
E
K
--
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
--
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
-
V
---
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
-
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------
86
Blastp_CBE
81.90
64%
-103
- C2 -
-
3Q4U
9.1
-
ACVR1_HUMAN
C:
[6-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
--
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
----
E
K
--
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
--
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
-
V
---
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
-
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------
65
Blastp_CBE
81.88
64%
-105
- C2 -
-
6SZM
7.7
-
?
B:
[7-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
D
I
T
L
L
--
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
----
E
K
--
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
--
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
-
V
---
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
-
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------
83
Blastp_CBE
81.87
64%
-105
- C2 -
-
4BGG
8.0
-
ACVR1_HUMAN
B:
[5-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
--
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
----
E
K
--
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
--
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
--------
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
-
V
---
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
-
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------
77
Blastp_CBE
81.79
64%
-104
- C2 -
-
5OXG
8.2
-
ACVR1_HUMAN
D:
[6-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
--
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
----
E
K
--
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
-----
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
-
V
---
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
-
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------
69
Blastp_CBE
81.54
64%
-103
- C2 -
-
6GIP
7.5
-
ACVR1_HUMAN
A:
[6-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
--
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
----
E
K
--
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
--
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
-
V
---
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
-
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------
92
Blastp_CBE
81.34
63%
-103
- C2 -
-
6ACR
7.2
-
ACVR1_HUMAN
B:
[5-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
H
Q
I
T
L
L
--
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
----
E
K
--
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
--
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
--------
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
-
V
---
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
-
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------
68
Blastp_CBE
80.56
64%
-111
- C2 -
-
6SRH
7.9
-
ACVR1_HUMAN
A:
[3-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
R
T
V
A
R
D
I
T
L
L
--
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
----
E
K
--
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
--
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
-----------
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
-
V
---
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
-
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------
76
Blastp_CBE
80.45
64%
-101
- C2 -
-
5OY6
6.4
-
ACVR1_HUMAN
A:
[6-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
--
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
----
E
K
--
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
--
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
----
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
-
V
---
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
-
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------
94
Blastp_CBE
80.34
63%
-106
- C2 -
-
4DYM
6.4
-
ACVR1_HUMAN
A:
[9-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
L
L
--
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
----
E
K
--
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
--
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
-
V
---
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
-
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------
259
HHSearch
80.26
63%
-111
- C2 -
-
6SRH
7.9
-
ACVR1_HUMAN
A:
[6-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
--
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
----
E
K
--
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
--
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
---
G
--
T
Q
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
-----------
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
-
V
---
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
-
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------
81
Blastp_CBE
79.68
64%
-105
- C2 -
-
4BGG
8.1
-
ACVR1_HUMAN
D:
[6-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
--
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
----
E
K
--
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
--------
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
--------
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
-
V
---
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
-
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------
62
Blastp_CBE
79.30
64%
-109
- C2 -
-
6T6D
7.4
-
?
C:
[7-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
D
I
T
L
L
--
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
----
E
K
--
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
--
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
------------
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
-----------
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
-
V
---
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
-
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------
82
Blastp_CBE
77.29
64%
-104
- C2 -
-
4BGG
8.0
-
ACVR1_HUMAN
C:
[6-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
--
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
----
E
K
--
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
--
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---------
G
--
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
---
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
-------------
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
-
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
--------------
267
HHSearch
65.42
41%
-41
- C2 -
-
4ASX
5.4
-
AVR2A_HUMAN
A:
[24-319]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
P
L
Q
L
L
--
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
--
E
Y
V
A
V
K
I
F
P
I
Q
D
----
K
Q
--
S
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
E
K
R
--
G
T
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
----
A
N
V
V
S
W
N
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
P
---
G
LK
D
G
H
--
K
P
A
--
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
E
A
G
K
S
A
--
G
-
T
H
G
Q
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
F
Q
-
R
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
-
T
---
A
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
-
Q
K
H
A
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
-----
Q
R
L
-----
127
Blastp_CBE
64.42
39%
-33
- C2 -
-
5E92
7.6
-
TGFR2_HUMAN
A:
[11-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
L
D
--
T
L
V
G
K
G
R
F
A
E
V
Y
K
A
K
L
K
-F-
E
T
V
A
V
K
I
F
P
Y
E
E
----
Y
A
--
S
W
K
T
E
K
D
I
F
S
D
I
N
L
K
H
E
N
I
L
Q
F
L
T
A
E
E
R
--
K
T
E
L
G
K
Q
Y
W
L
I
T
A
F
H
A
K
G
N
L
Q
E
Y
L
T
----
R
H
V
I
S
W
E
D
L
R
K
L
G
S
S
L
A
R
G
I
A
H
L
H
S
D
H
T
---
P
--
C
-
G
--
R
P
K
MP
I
V
H
R
D
L
K
S
S
N
I
L
V
K
N
D
L
T
C
C
L
C
D
F
G
L
S
L
R
L
D
P
T
L
S
V
D
D
L
A
N
S
G
Q
V
G
T
A
R
Y
M
A
P
E
V
L
A
S
A
M
N
L
E
N
V
E
S
F
K
Q
T
D
V
Y
S
M
A
L
V
L
W
E
M
T
S
R
C
-
N
---
A
V
-
G
E
V
K
D
Y
E
P
P
F
G
S
K
V
R
E
H
P
C
V
A
S
M
A
D
N
V
L
A
D
A
G
R
P
E
I
P
S
F
W
-
L
N
H
Q
G
I
Q
M
V
C
E
T
L
T
E
C
W
D
H
D
P
E
A
R
L
T
A
Q
C
V
A
E
R
F
S
E
L
-------------
125
Blastp_CBE
63.50
40%
-41
* C2 *
-
2QLU
3.0
-
AVR2B_HUMAN
A:
[16-306]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
Q
L
L
--
E
I
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
M
N
--
D
F
V
A
V
K
I
F
P
L
Q
D
----
K
Q
--
S
W
Q
S
E
R
E
I
F
S
T
P
G
M
K
H
E
N
L
L
Q
F
I
A
A
E
K
R
--
G
S
N
L
E
V
E
L
W
L
I
T
A
F
H
D
K
G
S
L
T
D
Y
L
K
----
G
N
I
I
T
W
N
E
L
C
H
V
A
E
T
M
S
R
G
L
S
Y
L
H
E
D
V
P
WCR
G
--
E
G
H
--
K
P
S
--
I
A
H
R
D
F
K
S
K
N
V
L
L
K
S
D
L
T
A
V
L
A
D
F
G
L
A
V
R
F
E
P
G
K
P
P
G
D
T
--
H
G
Q
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
F
Q
-
R
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
V
S
R
C
K
A
---
A
D
-
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
E
L
Q
E
V
V
V
H
K
K
M
R
P
T
I
K
D
H
W
-
L
K
H
P
G
L
A
Q
L
C
V
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
E
E
R
V
S
---------------
269
HHSearch
63.43
41%
-37
- C2 -
-
3SOC
7.2
-
AVR2A_HUMAN
A:
[24-320]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
P
L
Q
L
L
--
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
--
E
Y
V
A
V
K
I
F
P
I
Q
D
----
K
Q
--
S
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
E
K
R
--
G
T
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
----
A
N
V
V
S
W
N
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
P
---
G
LK
D
G
H
--
K
P
A
--
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
E
A
G
K
S
A
--
G
D
T
H
G
Q
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
F
Q
-
R
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
-
T
---
A
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
-
Q
K
H
A
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
-----
Q
R
L
T
----
260
HHSearch
63.37
39%
-14
- C2 -
-
5E8Y
8.5
-
TGFR2_HUMAN
A:
[9-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
I
E
L
D
--
T
L
V
G
K
G
R
F
A
E
V
Y
K
A
K
L
K
Q
QF
E
T
V
A
V
K
I
F
P
Y
E
E
----
Y
A
--
S
W
K
T
E
K
D
I
F
S
D
I
N
L
K
H
E
N
I
L
Q
F
L
T
A
E
E
R
--
K
T
E
L
G
K
Q
Y
W
L
I
T
A
F
H
A
K
G
N
L
Q
E
Y
L
T
----
R
H
V
I
S
W
E
D
L
R
K
L
G
S
S
L
A
R
G
I
A
H
L
H
S
D
H
T
P--
C
--
G
R
P
--
K
M
P
--
I
V
H
R
D
L
K
S
S
N
I
L
V
K
N
D
L
T
C
C
L
C
D
F
G
L
S
L
R
L
D
P
T
L
S
V
D
D
L
A
N
S
G
Q
V
G
T
A
R
Y
M
A
P
E
V
L
A
S
A
M
N
L
E
N
V
E
S
F
K
Q
T
D
V
Y
S
M
A
L
V
L
W
E
M
T
S
R
C
-
N
---
A
V
-
G
E
V
K
D
Y
E
P
P
F
G
S
K
V
R
E
H
P
C
V
A
S
M
A
D
N
V
L
A
D
A
G
R
P
E
I
P
S
F
W
-
L
N
H
Q
G
I
Q
M
V
C
E
T
L
T
E
C
W
D
H
D
P
E
A
R
L
T
A
Q
C
V
A
E
R
F
S
E
L
-------------
264
HHSearch
63.02
39%
-10
- C2 -
-
5QIN
8.2
-
TGFR2_HUMAN
A:
[9-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
I
E
L
D
--
T
L
V
G
K
G
R
F
A
E
V
Y
K
A
K
L
K
-QF
E
T
V
A
V
K
I
F
P
Y
E
E
----
Y
A
--
S
W
K
T
E
K
D
I
F
S
D
I
N
L
K
H
E
N
I
L
Q
F
L
T
A
E
E
R
--
K
T
E
L
G
K
Q
Y
W
L
I
T
A
F
H
A
K
G
N
L
Q
E
Y
L
T
----
R
H
V
I
S
W
E
D
L
R
K
L
G
S
S
L
A
R
G
I
A
H
L
H
S
D
H
T
---
P
C-
G
R
P
--
K
M
P
--
I
V
H
R
D
L
K
S
S
N
I
L
V
K
N
D
L
T
C
C
L
C
D
F
G
L
S
L
R
L
D
P
T
L
S
V
D
D
L
A
N
--
Q
V
G
T
A
R
Y
M
A
P
E
V
L
A
S
A
M
N
L
E
N
V
E
S
F
K
Q
T
D
V
Y
S
M
A
L
V
L
W
E
M
T
S
R
C
-
N
---
A
V
-
G
E
V
K
D
Y
E
P
P
F
G
S
K
V
R
E
H
P
C
V
A
S
M
A
D
N
V
L
A
D
A
G
R
P
E
I
P
S
F
W
-
L
N
H
Q
G
I
Q
M
V
C
E
T
L
T
E
C
W
D
H
D
P
E
A
R
L
T
A
Q
C
V
A
E
R
F
S
E
L
-------------
128
Blastp_CBE
62.56
39%
-18
- C2 -
-
5E91
6.7
-
TGFR2_HUMAN
A:
[11-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
L
D
--
T
L
V
G
K
G
R
F
A
E
V
Y
K
A
K
L
K
---
E
T
V
A
V
K
I
F
P
Y
E
E
----
Y
A
--
S
W
K
T
E
K
D
I
F
S
D
I
N
L
K
H
E
N
I
L
Q
F
L
T
A
E
E
R
--
K
T
E
L
G
K
Q
Y
W
L
I
T
A
F
H
A
K
G
N
L
Q
E
Y
L
T
----
R
H
V
I
S
W
E
D
L
R
K
L
G
S
S
L
A
R
G
I
A
H
L
H
S
D
H
T
---
P
--
C
-
G
--
R
P
K
MP
I
V
H
R
D
L
K
S
S
N
I
L
V
K
N
D
L
T
C
C
L
C
D
F
G
L
S
L
R
L
D
P
T
L
S
V
D
D
L
A
N
S
G
Q
V
G
T
A
R
Y
M
A
P
E
V
L
A
S
A
M
N
L
E
N
V
E
S
F
K
Q
T
D
V
Y
S
M
A
L
V
L
W
E
M
T
S
R
C
-
N
---
A
V
-
G
E
V
K
D
Y
E
P
P
F
G
S
K
V
R
E
H
P
C
V
A
S
M
A
D
N
V
L
A
D
A
G
R
P
E
I
P
S
F
W
-
L
N
H
Q
G
I
Q
M
V
C
E
T
L
T
E
C
W
D
H
D
P
E
A
R
L
T
A
Q
C
V
A
E
R
F
S
E
L
-------------
129
Blastp_CBE
61.58
39%
0
- C2 -
-
5E8Y
8.5
-
TGFR2_HUMAN
A:
[11-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
L
D
--
T
L
V
G
K
G
R
F
A
E
V
Y
K
A
K
L
K
Q
QF
E
T
V
A
V
K
I
F
P
Y
E
E
----
Y
A
--
S
W
K
T
E
K
D
I
F
S
D
I
N
L
K
H
E
N
I
L
Q
F
L
T
A
E
E
R
--
K
T
E
L
G
K
Q
Y
W
L
I
T
A
F
H
A
K
G
N
L
Q
E
Y
L
T
----
R
H
V
I
S
W
E
D
L
R
K
L
G
S
S
L
A
R
G
I
A
H
L
H
S
D
H
T
---
P
--
C
-
G
--
R
P
K
MP
I
V
H
R
D
L
K
S
S
N
I
L
V
K
N
D
L
T
C
C
L
C
D
F
G
L
S
L
R
L
D
P
T
L
S
V
D
D
L
A
N
S
G
Q
V
G
T
A
R
Y
M
A
P
E
V
L
A
S
A
M
N
L
E
N
V
E
S
F
K
Q
T
D
V
Y
S
M
A
L
V
L
W
E
M
T
S
R
C
-
N
---
A
V
-
G
E
V
K
D
Y
E
P
P
F
G
S
K
V
R
E
H
P
C
V
A
S
M
A
D
N
V
L
A
D
A
G
R
P
E
I
P
S
F
W
-
L
N
H
Q
G
I
Q
M
V
C
E
T
L
T
E
C
W
D
H
D
P
E
A
R
L
T
A
Q
C
V
A
E
R
F
S
E
L
-------------
126
Blastp_CBE
60.91
39%
3
- C2 -
-
5QIN
8.2
-
TGFR2_HUMAN
A:
[11-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
L
D
--
T
L
V
G
K
G
R
F
A
E
V
Y
K
A
K
L
K
-QF
E
T
V
A
V
K
I
F
P
Y
E
E
----
Y
A
--
S
W
K
T
E
K
D
I
F
S
D
I
N
L
K
H
E
N
I
L
Q
F
L
T
A
E
E
R
--
K
T
E
L
G
K
Q
Y
W
L
I
T
A
F
H
A
K
G
N
L
Q
E
Y
L
T
----
R
H
V
I
S
W
E
D
L
R
K
L
G
S
S
L
A
R
G
I
A
H
L
H
S
D
H
T
---
P
--
C
-
G
--
R
P
K
MP
I
V
H
R
D
L
K
S
S
N
I
L
V
K
N
D
L
T
C
C
L
C
D
F
G
L
S
L
R
L
D
P
T
L
S
V
D
D
L
A
N
--
Q
V
G
T
A
R
Y
M
A
P
E
V
L
A
S
A
M
N
L
E
N
V
E
S
F
K
Q
T
D
V
Y
S
M
A
L
V
L
W
E
M
T
S
R
C
-
N
---
A
V
-
G
E
V
K
D
Y
E
P
P
F
G
S
K
V
R
E
H
P
C
V
A
S
M
A
D
N
V
L
A
D
A
G
R
P
E
I
P
S
F
W
-
L
N
H
Q
G
I
Q
M
V
C
E
T
L
T
E
C
W
D
H
D
P
E
A
R
L
T
A
Q
C
V
A
E
R
F
S
E
L
-------------
119
Blastp_CBE
57.56
41%
13
- C2 -
-
4ASX
5.4
-
AVR2A_HUMAN
B:
[14-316]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
T
E
N
L
Y
F
Q
S
M
P
L
Q
LL
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
--
E
Y
V
A
V
K
I
F
P
I
Q
D
----
K
Q
--
S
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
E
K
R
--
G
T
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
----
A
N
V
V
S
W
N
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
P
---
G
--
L
K
D
GH
K
P
A
--
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
E
A
G
K
S
A
G
D
T
--
H
G
Q
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
F
Q
-
R
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
-
T
---
A
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
-
Q
K
H
A
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
-------------
123
Blastp_CBE
57.11
41%
13
- C2 -
-
3Q4T
5.9
-
AVR2A_HUMAN
B:
[10-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
V
D
L
G
T
E
N
L
Y
F
Q
S
M
P
L
Q
LL
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
--
E
Y
V
A
V
K
I
F
P
I
Q
D
----
K
Q
--
S
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
E
K
R
--
G
T
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
----
A
N
V
V
S
W
N
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
P
---
G
--
L
K
D
GH
K
P
A
--
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
E
A
G
K
S
A
--
T
--
H
G
Q
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
F
Q
-
R
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
-
T
---
A
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
-
Q
K
H
A
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
-------------
124
Blastp_CBE
57.07
41%
14
- C2 -
-
3Q4T
4.7
-
AVR2A_HUMAN
A:
[14-316]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
T
E
N
L
Y
F
Q
S
M
P
L
Q
LL
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
--
E
Y
V
A
V
K
I
F
P
I
Q
D
----
K
Q
--
S
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
E
K
R
--
G
T
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
----
A
N
V
V
S
W
N
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
P
---
G
--
L
K
D
GH
K
P
A
--
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
E
A
G
K
S
A
G
D
T
--
H
G
Q
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
F
Q
-
R
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
-
T
---
A
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
-
Q
K
H
A
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
-------------
120
Blastp_CBE
56.89
41%
13
- C2 -
-
4ASX
5.4
-
AVR2A_HUMAN
A:
[10-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
V
D
L
G
T
E
N
L
Y
F
Q
S
M
P
L
Q
LL
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
--
E
Y
V
A
V
K
I
F
P
I
Q
D
----
K
Q
--
S
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
E
K
R
--
G
T
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
----
A
N
V
V
S
W
N
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
P
---
G
--
L
K
D
GH
K
P
A
--
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
E
A
G
K
S
A
G
-
T
--
H
G
Q
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
F
Q
-
R
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
-
T
---
A
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
-
Q
K
H
A
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
-------------
121
Blastp_CBE
56.70
41%
14
- C2 -
-
3SOC
7.1
-
AVR2A_HUMAN
B:
[10-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
V
D
L
G
T
E
N
L
Y
F
Q
S
M
P
L
Q
LL
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
--
E
Y
V
A
V
K
I
F
P
I
Q
D
----
K
Q
--
S
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
E
K
R
--
G
T
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
----
A
N
V
V
S
W
N
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
P
---
G
--
L
K
D
GH
K
P
A
--
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
E
A
G
K
S
A
--
T
--
H
G
Q
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
F
Q
-
R
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
-
T
---
A
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
-
Q
K
H
A
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
-------------
122
Blastp_CBE
56.50
41%
12
- C2 -
-
3SOC
7.2
-
AVR2A_HUMAN
A:
[14-316]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
T
E
N
L
Y
F
Q
S
M
P
L
Q
LL
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
--
E
Y
V
A
V
K
I
F
P
I
Q
D
----
K
Q
--
S
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
E
K
R
--
G
T
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
----
A
N
V
V
S
W
N
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
P
---
G
--
L
K
D
GH
K
P
A
--
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
E
A
G
K
S
A
G
D
T
--
H
G
Q
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
F
Q
-
R
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
-
T
---
A
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
-
Q
K
H
A
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
-------------
132
Blastp_CBE
52.15
38%
-14
- C2 -
-
3G2F
6.2
-
BMPR2_HUMAN
A:
[17-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
--
E
L
I
G
R
G
R
Y
G
A
V
Y
K
G
S
L
D
E
--
R
P
V
A
V
K
V
F
S
F
A
N
----
R
Q
--
N
F
I
N
E
K
N
I
Y
R
V
P
L
M
E
H
D
N
I
A
R
F
I
V
G
D
E
R
VT
A
D
G
R
M
E
Y
L
-
L
V
M
E
Y
Y
P
N
G
S
L
C
K
Y
L
S
----
L
H
T
S
D
W
V
S
S
C
R
L
A
H
S
V
T
R
G
L
A
Y
L
H
T
E
L
P
R--
G
--
D
H
Y
--
K
P
A
--
I
S
H
R
D
L
N
S
R
N
V
L
V
K
N
D
G
T
C
V
I
S
D
F
G
L
S
M
R
L
T
G
--
N
R
L
V
R
P
---
E
V
G
T
I
R
Y
M
A
P
E
V
L
E
G
A
V
N
L
R
D
E
S
A
L
K
Q
V
D
M
Y
A
L
G
L
I
Y
W
E
I
F
M
R
C
-
T
DLF
P
G
-
E
S
V
P
E
Y
Q
M
A
F
Q
T
E
V
G
N
H
P
T
F
E
D
M
Q
V
L
V
S
R
E
K
Q
R
P
K
F
P
E
A
W
K
E
N
S
L
A
V
R
S
L
K
E
T
I
E
D
C
W
D
Q
D
A
E
A
R
L
T
A
-----------------------
131
Blastp_CBE
51.46
38%
-10
- C2 -
-
3G2F
6.1
-
BMPR2_HUMAN
B:
[17-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
--
E
L
I
G
R
G
R
Y
G
A
V
Y
K
G
S
L
D
E
--
R
P
V
A
V
K
V
F
S
F
A
N
----
R
Q
--
N
F
I
N
E
K
N
I
Y
R
V
P
L
M
E
H
D
N
I
A
R
F
I
V
G
D
E
R
VT
A
D
G
R
M
E
Y
L
-
L
V
M
E
Y
Y
P
N
G
S
L
C
K
Y
L
S
----
L
H
T
S
D
W
V
S
S
C
R
L
A
H
S
V
T
R
G
L
A
Y
L
H
T
E
L
P
R--
G
--
D
H
Y
--
K
P
A
--
I
S
H
R
D
L
N
S
R
N
V
L
V
K
N
D
G
T
C
V
I
S
D
F
G
L
S
M
R
L
T
G
--
N
R
L
-------
V
G
T
I
R
Y
M
A
P
E
V
L
E
G
A
V
N
L
R
D
E
S
A
L
K
Q
V
D
M
Y
A
L
G
L
I
Y
W
E
I
F
M
R
C
-
T
DLF
P
G
-
E
S
V
P
E
Y
Q
M
A
F
Q
T
E
V
G
N
H
P
T
F
E
D
M
Q
V
L
V
S
R
E
K
Q
R
P
K
F
P
E
A
W
K
E
N
S
L
A
V
R
S
L
K
E
T
I
E
D
C
W
D
Q
D
A
E
A
R
L
T
A
-----------------------
134
Blastp_CBE
36.53
34%
-13
- C2 -
-
3P86
7.3
-
CTR1_ARATH
A:
[41-233]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
--
E
K
I
G
A
G
S
F
G
T
V
H
R
A
E
W
H
G
--
S
D
V
A
V
K
I
L
M
E
Q
D
FHA-
E
R
VN
E
F
L
R
E
V
A
I
M
K
R
--
L
R
H
P
N
I
V
L
F
M
G
A
V
T
Q
--
P
----
P
N
L
S
I
V
T
E
Y
L
S
R
G
S
L
Y
R
L
L
H
KSGA
R
E
Q
L
D
E
R
R
R
L
S
M
A
Y
D
V
A
K
G
M
N
Y
L
H
-----------
N
R
--
N
P
P
--
I
V
H
R
N
L
K
S
P
N
L
L
V
D
K
K
Y
T
V
K
V
C
D
F
---------------------
G
T
P
E
W
M
A
P
E
V
L
R
D
E
------
P
S
N
E
K
S
D
V
Y
S
F
G
V
I
L
W
E
L
A
------------------------------------------------------------------------------------------------------
136
Blastp_CBE
36.25
33%
-33
- C2 -
-
3OMV
4.3
-
RAF1_HUMAN
A:
[35-230]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
E
V
M
L
S
--
T
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
---
D
V
A
V
K
I
L
K
V
V
D
PTPE
Q
F
--
Q
A
F
R
N
-
E
V
A
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
M
T
K
--
D
N
-----
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
K
H
L
H
VQ--
E
T
K
F
Q
M
F
Q
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---------------
N
--
I
I
H
R
D
M
K
S
N
N
I
F
L
H
E
G
L
T
V
K
I
G
D
F
G
L
A
T
V
--------------
P
T
G
S
V
L
W
M
A
P
E
V
I
--
R
M
Q
D
N
N
P
F
S
F
Q
-
S
D
V
Y
S
Y
G
I
V
L
Y
E
L
-------------------------------------------------------------------------------------------------------
133
Blastp_CBE
36.14
35%
-3
- C2 -
-
3PPZ
8.1
-
CTR1_ARATH
A:
[41-233]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
--
E
K
I
G
A
G
S
F
G
T
V
H
R
A
E
W
H
G
--
S
D
V
A
V
K
I
L
M
E
--A---
E
R
VN
E
F
L
R
E
V
A
I
M
K
R
--
L
R
H
P
N
I
V
L
F
M
G
A
V
T
Q
--
P
----
P
N
L
S
I
V
T
E
Y
L
S
R
G
S
L
Y
R
L
L
H
KSGA
R
E
Q
L
D
E
R
R
R
L
S
M
A
Y
D
V
A
K
G
M
N
Y
L
H
-----------
N
R
--
N
P
P
--
I
V
H
R
D
L
K
S
P
N
L
L
V
D
K
K
Y
T
V
K
V
C
D
F
G
L
S
R
L
K
A
S
F
L
S
K
S
K
-----
A
A
G
T
P
E
W
M
A
P
E
V
L
R
D
E
------
P
S
N
E
K
S
D
V
Y
S
F
G
V
I
L
W
E
L
A
------------------------------------------------------------------------------------------------------