@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Screening
Virtual Screening Score
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ACVL1_HUMAN: (2020-09-04 )
MTLGSPRKGLLMLLMALVTQGDPVKPSRGPLVTCTCESPHCKGPTCRGAWCTVVLVREEGRHPQEHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDGQLALILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKISNSPEKPKVIQ
Atome Classification :
(106 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220-..--..-....230--......-----.240.......250.......260.-......270.......280.......290--.----........300.......310.....-.-.-320..---...--....330.......340.......350.......360.......370.---......380.......390.......400.......410--..-......420.......430.......440.......450.......460........470.......480.......490.......500.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(pKd)
(pKd)
(Uniprot)
MTLGSP
R
K
G
L
L
M
L
L
M
A
L
VTQGDPVKPSRG
P
L
V
T
C
TCESPHCKGPTCRG
A
W
C
T
V
V
L
V
REEGRH
P
Q
E
HR
G
C
G
N
L
H
R
E
L
CRGR
P
T
E
F
V
N
H
Y
CCDSHLCNHN
V
S
L
V
L
E
ATQPPSEQPGTDG
Q
L
A
L
I
L
G
P
V
L
A
L
L
A
L
V
A
L
G
V
L
G
L
W
H
V
R
R
R
Q
E
K
Q
R
G
L
H
S
E
LGES
S
L
I
L
K
ASEQG
D
S
M
L
G
D
L
L
DSDCTTGSGSG
L
P
F
L
V
Q
R
T
V
A
R
Q
V
A
L
V
E
C
VGKGR
Y
G
E
V
W
R
G
LW--HG--
E
S
-
V
A
V
K
I
FS--SR
D
E
Q
S
-----
W
F
R
E
T
E
I
Y
N
T
V
L
L
RHDN
I
L
G
F
I
A
S
D
-MTSRNSS
T
Q
L
W
L
I
T
H
YHEHG
S
L
Y
D
F
L
Q
----
R
----QTL
E
P
H
L
A
L
R
L
A
V
S
AACG
L
A
H
L
H
V
E
I
-
F
-G-T--QG---KPA--IAHRDFKSR
N
V
L
VKSN
L
Q
C
C
I
A
D
L
G
L
A
V
MHSQGSD
Y
L
DIGNNPRVGTK---RYM
A
P
E
V
L
D
E
Q
I
R
T
D
C
F
E
SYKW
T
D
I
W
A
F
G
L
V
L
W
E
I
A
R
R
---
T
I
-
V
N
G
I
V
E
DYRPP
F
Y
DVVPNDP
S
F
E
D
M
K
K
V
V
C
VDQQTPTIPNRLAA
D
P
V
-
L
S
G
L
A
Q
M
M
R
E
CWYPNP
S
A
R
L
T
A
L
R
I
K
K
T
L
Q
K
I
SNSPEKPKVIQ
1
PsiBlast_PDB
92.06
99%
-106
- C1 -
-
3MY0
-
-
ACVL1_HUMAN
A:
[2-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
Q
R
T
V
A
R
Q
V
A
L
V
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
L
W
--
H
G
--
E
S
-
V
A
V
K
I
F
S
--
S
R
D
E
Q
S
-----
W
F
R
E
T
E
I
Y
N
T
V
L
L
R
H
D
N
I
L
G
F
I
A
S
D
-
M
T
----
S
T
Q
L
W
L
I
T
H
Y
H
E
H
G
S
L
Y
D
F
L
Q
----
R
----
Q
T
L
E
P
H
L
A
L
R
L
A
V
S
A
A
C
G
L
A
H
L
H
V
E
I
-
F
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
F
K
S
R
N
V
L
V
K
S
N
L
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
G
S
D
Y
L
D
I
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
E
Q
I
R
T
D
C
F
E
S
Y
K
W
T
D
I
W
A
F
G
L
V
L
W
E
I
A
R
R
---
T
I
-
V
N
G
I
V
E
D
Y
R
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
K
K
V
V
C
V
D
Q
Q
T
P
T
I
P
N
R
L
A
A
D
P
V
-
L
S
G
L
A
Q
M
M
R
E
C
W
Y
P
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
Q
K
I
S
----------
4
PsiBlast_PDB
92.05
79%
-118
- C1 -
-
4C02
7.1
-
ACVR1_HUMAN
A:
[9-329]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
L
A
D
L
L
D
----
S
G
S
G
S
G
L
P
F
L
V
Q
R
T
V
A
R
Q
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
--
Q
G
--
E
N
-
V
A
V
K
I
F
S
--
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
--
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
----
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
---
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
-
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
-
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
39
Blastp_CBE
91.96
99%
-110
- C1 -
-
3MY0
-
-
ACVL1_HUMAN
F:
[2-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
Q
R
T
V
A
R
Q
V
A
L
V
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
L
W
--
H
G
--
E
S
-
V
A
V
K
I
F
S
--
S
R
D
E
Q
S
-----
W
F
R
E
T
E
I
Y
N
T
V
L
L
R
H
D
N
I
L
G
F
I
A
S
D
-
M
------
T
Q
L
W
L
I
T
H
Y
H
E
H
G
S
L
Y
D
F
L
Q
----
R
----
Q
T
L
E
P
H
L
A
L
R
L
A
V
S
A
A
C
G
L
A
H
L
H
V
E
I
-
F
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
F
K
S
R
N
V
L
V
K
S
N
L
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
G
S
D
Y
L
D
I
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
E
Q
I
R
T
D
C
F
E
S
Y
K
W
T
D
I
W
A
F
G
L
V
L
W
E
I
A
R
R
---
T
I
-
V
N
G
I
V
E
D
Y
R
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
K
K
V
V
C
V
D
Q
Q
T
P
T
I
P
N
R
L
A
A
D
P
V
-
L
S
G
L
A
Q
M
M
R
E
C
W
Y
P
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
Q
K
I
S
----------
5
PsiBlast_PDB
91.35
79%
-109
- C1 -
-
6I1S
7.8
-
ACVR1_HUMAN (first)
A:
[7-329]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
S
T
L
A
D
L
L
D
H
-----
S
G
S
G
L
P
F
L
V
Q
R
T
V
A
R
Q
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
--
Q
G
--
E
N
-
V
A
V
K
I
F
S
--
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
---
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
----
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
-
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
-
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
43
Blastp_CBE
91.29
99%
-106
- C1 -
-
3MY0
-
-
ACVL1_HUMAN
B:
[3-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
R
T
V
A
R
Q
V
A
L
V
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
L
W
--
H
G
--
E
S
-
V
A
V
K
I
F
S
--
S
R
D
E
Q
S
-----
W
F
R
E
T
E
I
Y
N
T
V
L
L
R
H
D
N
I
L
G
F
I
A
S
D
-
M
T
-----
T
Q
L
W
L
I
T
H
Y
H
E
H
G
S
L
Y
D
F
L
Q
----
R
----
Q
T
L
E
P
H
L
A
L
R
L
A
V
S
A
A
C
G
L
A
H
L
H
V
E
I
-
F
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
F
K
S
R
N
V
L
V
K
S
N
L
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
G
S
D
Y
L
D
I
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
E
Q
I
R
T
D
C
F
E
S
Y
K
W
T
D
I
W
A
F
G
L
V
L
W
E
I
A
R
R
---
T
I
-
V
N
G
I
V
E
D
Y
R
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
K
K
V
V
C
V
D
Q
Q
T
P
T
I
P
N
R
L
A
A
D
P
V
-
L
S
G
L
A
Q
M
M
R
E
C
W
Y
P
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
Q
K
I
S
N
---------
3
PsiBlast_PDB
90.02
79%
-114
- C1 -
-
3H9R
7.9
-
ACVR1_HUMAN
A:
[7-329]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
S
T
L
A
D
L
L
D
H
S
C
T
S
G
S
G
S
G
L
P
F
L
V
Q
R
T
V
A
R
Q
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
--
Q
G
--
E
N
-
V
A
V
K
I
F
S
--
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
---
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
----
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
-------------
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
-
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
-
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
2
PsiBlast_PDB
89.67
78%
-101
- C1 -
-
6EIX
7.1
-
ACVR1_HUMAN
A:
[23-334]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
S
G
L
P
F
L
V
Q
R
T
V
A
R
E
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
--
Q
G
--
E
N
-
V
A
V
K
I
F
S
--
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
----
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
-
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
-
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
D
N
S
L
D
------
72
Blastp_CBE
89.59
63%
-114
- C1 -
-
3FAA
-
-
TGFR1_HUMAN
E:
[14-336]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
--
R
G
--
E
E
-
V
A
V
K
I
F
S
--
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
----
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
---
C
S
-
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
-
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
---------
76
Blastp_CBE
89.51
63%
-119
- C1 -
-
3FAA
-
-
TGFR1_HUMAN
A:
[14-336]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
--
R
G
--
E
E
-
V
A
V
K
I
F
S
--
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
----
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
--
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
---
C
S
-
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
-
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
---------
71
Blastp_CBE
89.07
63%
-114
- C1 -
-
3KCF
-
-
TGFR1_HUMAN
A:
[14-336]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
--
R
G
--
E
E
-
V
A
V
K
I
F
S
--
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
----
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
--
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
---
C
S
-
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
-
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
---------
78
Blastp_CBE
88.94
63%
-110
- C1 -
-
2X7O
-
-
TGFR1_HUMAN
D:
[14-336]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
--
R
G
--
E
E
-
V
A
V
K
I
F
S
--
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
----
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
---
C
S
-
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
-
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
---------
77
Blastp_CBE
88.94
63%
-110
- C1 -
-
2X7O
-
-
TGFR1_HUMAN
E:
[14-336]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
--
R
G
--
E
E
-
V
A
V
K
I
F
S
--
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
----
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
---
C
S
-
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
-
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
---------
116
Blastp_CBE
88.82
62%
-122
* C1 *
-
5E8X
8.6
-
TGFR1_HUMAN
A:
[4-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
D
I
V
L
Q
E
S
V
G
K
G
R
F
G
E
V
W
R
G
K
W
--
R
G
--
E
E
-
V
A
V
K
I
F
S
--
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
F
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
T
D
F
H
E
H
G
N
L
F
D
Y
L
N
----
R
----
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
C
D
F
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
---
C
S
-
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
-
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
----------
75
Blastp_CBE
88.80
63%
-120
- C1 -
-
3FAA
-
-
TGFR1_HUMAN
B:
[14-336]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
--
R
G
--
E
E
-
V
A
V
K
I
F
S
--
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
----
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---------
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
---
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
---
C
S
-
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
-
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
---------
68
Blastp_CBE
88.80
63%
-114
- C1 -
-
3KCF
-
-
TGFR1_HUMAN
D:
[14-336]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
--
R
G
--
E
E
-
V
A
V
K
I
F
S
--
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
----
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
---
C
S
-
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
-
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
---------
81
Blastp_CBE
88.78
63%
-109
- C1 -
-
2X7O
-
-
TGFR1_HUMAN
A:
[14-336]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
--
R
G
--
E
E
-
V
A
V
K
I
F
S
--
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
----
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
---
C
S
-
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
-
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
---------
64
Blastp_CBE
88.65
79%
-111
- C1 -
-
3MTF
-
-
ACVR1_HUMAN
B:
[4-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
--
Q
G
--
E
N
-
V
A
V
K
I
F
S
--
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
----
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
-
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
-
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
79
Blastp_CBE
88.64
63%
-109
- C1 -
-
2X7O
-
-
TGFR1_HUMAN
C:
[14-336]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
--
R
G
--
E
E
-
V
A
V
K
I
F
S
--
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
----
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
---
C
S
-
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
-
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
---------
61
Blastp_CBE
88.51
79%
-107
- C1 -
-
3Q4U
-
-
ACVR1_HUMAN
D:
[3-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
R
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
--
Q
G
--
E
N
-
V
A
V
K
I
F
S
--
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
----
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
-
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
-
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
70
Blastp_CBE
88.45
63%
-115
- C1 -
-
3KCF
-
-
TGFR1_HUMAN
B:
[14-336]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
--
R
G
--
E
E
-
V
A
V
K
I
F
S
--
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
----
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---------
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
---
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
---
C
S
-
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
-
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
---------
227
HHSearch
88.40
62%
-120
- C1 -
-
5E8X
8.6
-
TGFR1_HUMAN
A:
[5-303]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
R
D
I
V
L
Q
E
S
V
G
K
G
R
F
G
E
V
W
R
G
K
W
--
R
G
--
E
E
-
V
A
V
K
I
F
S
--
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
F
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
T
D
F
H
E
H
G
N
L
F
D
Y
L
N
----
R
----
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
C
D
F
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
---
C
S
-
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
-
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
-------
20
PsiBlast_PDB
88.38
78%
-112
- C1 -
-
6ACR
7.1
-
ACVR1_HUMAN
A:
[5-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
H
Q
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
--
Q
G
--
E
N
-
V
A
V
K
I
F
S
--
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
----
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
-----
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
-
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
-
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
6
PsiBlast_PDB
88.19
78%
-109
- C1 -
-
3MTF
7.4
-
ACVR1_HUMAN
A:
[5-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
--
Q
G
--
E
N
-
V
A
V
K
I
F
S
--
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
----
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
-
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
-
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
56
Blastp_CBE
87.82
79%
-105
- C1 -
-
5OXG
8.5
-
ACVR1_HUMAN
C:
[2-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
Q
R
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
--
Q
G
--
E
N
-
V
A
V
K
I
F
S
--
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
----
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
-
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
-
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
63
Blastp_CBE
87.58
79%
-112
- C1 -
-
3Q4U
8.8
-
ACVR1_HUMAN
B:
[2-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
Q
R
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
--
Q
G
--
E
N
-
V
A
V
K
I
F
S
--
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
----
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
-
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
-
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
50
Blastp_CBE
87.58
79%
-111
- C1 -
-
6SRH
8.1
-
ACVR1_HUMAN
B:
[7-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
--
Q
G
--
E
N
-
V
A
V
K
I
F
S
--
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
----
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
-
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
-
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
49
Blastp_CBE
87.39
79%
-108
- C1 -
-
6SZM
7.9
-
?
B:
[7-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
--
Q
G
--
E
N
-
V
A
V
K
I
F
S
--
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
----
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
-
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
-
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
19
PsiBlast_PDB
87.24
78%
-110
- C1 -
-
4DYM
6.6
-
ACVR1_HUMAN
A:
[9-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
--
Q
G
--
E
N
-
V
A
V
K
I
F
S
--
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
----
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
-
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
-
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
60
Blastp_CBE
87.22
79%
-108
- C1 -
-
4BGG
8.2
-
ACVR1_HUMAN
B:
[5-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
--
Q
G
--
E
N
-
V
A
V
K
I
F
S
--
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
----
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-------
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
-
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
-
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
48
Blastp_CBE
87.22
79%
-109
- C1 -
-
6T6D
7.1
-
?
B:
[5-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
--
Q
G
--
E
N
-
V
A
V
K
I
F
S
--
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
----
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
-
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
-
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
65
Blastp_CBE
87.21
79%
-108
- C1 -
-
6ACR
7.2
-
ACVR1_HUMAN
B:
[5-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
H
Q
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
--
Q
G
--
E
N
-
V
A
V
K
I
F
S
--
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
----
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-------
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
-
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
-
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
57
Blastp_CBE
87.20
79%
-107
- C1 -
-
5OXG
8.2
-
ACVR1_HUMAN
B:
[5-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
--
Q
G
--
E
N
-
V
A
V
K
I
F
S
--
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
----
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
-
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
-
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
8
PsiBlast_PDB
87.12
78%
-110
- C1 -
-
3Q4U
8.6
-
ACVR1_HUMAN
A:
[4-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
--
Q
G
--
E
N
-
V
A
V
K
I
F
S
--
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
----
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
-
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
-
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
10
PsiBlast_PDB
87.10
78%
-108
- C1 -
-
5OXG
8.5
-
ACVR1_HUMAN
A:
[5-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
--
Q
G
--
E
N
-
V
A
V
K
I
F
S
--
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
---
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
----
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
-
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
-
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
17
PsiBlast_PDB
87.01
78%
-116
- C1 -
-
6T6D
7.6
-
?
A:
[6-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
--
Q
G
--
E
N
-
V
A
V
K
I
F
S
--
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
----
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
-
L
D
V
---
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
-
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
-
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
7
PsiBlast_PDB
87.01
78%
-110
- C1 -
-
3OOM
7.2
-
ACVR1_HUMAN
A:
[5-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
--
Q
G
--
E
N
-
V
A
V
K
I
F
S
--
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
----
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
-
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
-
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
51
Blastp_CBE
86.97
79%
-111
- C1 -
-
6GIN
8.6
-
ACVR1_HUMAN
B:
[6-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
--
Q
G
--
E
N
-
V
A
V
K
I
F
S
--
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
----
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
-
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
-
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
13
PsiBlast_PDB
86.96
78%
-111
- C1 -
-
6GIN
8.8
-
ACVR1_HUMAN
A:
[6-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
--
Q
G
--
E
N
-
V
A
V
K
I
F
S
--
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
----
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
-
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
-
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
229
HHSearch
86.73
79%
-106
- C1 -
-
5OXG
8.5
-
ACVR1_HUMAN
C:
[6-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
--
Q
G
--
E
N
-
V
A
V
K
I
F
S
--
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
----
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
-
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
-
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
12
PsiBlast_PDB
86.72
78%
-109
- C1 -
-
6GI6
6.7
-
ACVR1_HUMAN
A:
[4-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
--
Q
G
--
E
N
-
V
A
V
K
I
F
S
--
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
----
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
-
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
-
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
9
PsiBlast_PDB
86.70
78%
-106
- C1 -
-
4BGG
8.1
-
ACVR1_HUMAN
A:
[5-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
--
Q
G
--
E
N
-
V
A
V
K
I
F
S
--
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
----
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
-
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
-
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
18
PsiBlast_PDB
86.64
78%
-109
- C1 -
-
6T8N
8.4
-
?
A:
[5-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
--
Q
G
--
E
N
-
V
A
V
K
I
F
S
--
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
---
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
----
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
-
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
-
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
44
Blastp_CBE
86.56
79%
-110
- C1 -
-
6TN8
6.0
-
?
A:
[6-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
--
Q
G
--
E
N
-
V
A
V
K
I
F
S
--
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
----
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
-
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
-
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
55
Blastp_CBE
86.55
79%
-108
- C1 -
-
5OXG
8.2
-
ACVR1_HUMAN
D:
[6-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
--
Q
G
--
E
N
-
V
A
V
K
I
F
S
--
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
---
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
----
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
-
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
-
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
45
Blastp_CBE
86.55
79%
-108
- C1 -
-
6T8N
8.8
-
?
B:
[5-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
--
Q
G
--
E
N
-
V
A
V
K
I
F
S
--
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
----
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
----
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
-
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
-
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
62
Blastp_CBE
86.50
79%
-108
- C1 -
-
3Q4U
9.1
-
ACVR1_HUMAN
C:
[6-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
--
Q
G
--
E
N
-
V
A
V
K
I
F
S
--
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
----
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
-
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
-
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
107
Blastp_CBE
85.56
63%
-115
- C1 -
-
2WOU
6.4
-
TGFR1_HUMAN
A:
[3-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
--
R
G
--
E
E
-
V
A
V
K
I
F
S
--
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
----
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
---
C
S
-
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
-
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
----------
15
PsiBlast_PDB
85.52
78%
-112
- C1 -
-
6SRH
8.1
-
ACVR1_HUMAN
A:
[3-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
R
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
--
Q
G
--
E
N
-
V
A
V
K
I
F
S
--
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
----
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
-----------
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
-
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
-
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
112
Blastp_CBE
85.40
63%
-115
- C1 -
-
1VJY
7.2
-
TGFR1_HUMAN
A:
[1-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
--
R
G
--
E
E
-
V
A
V
K
I
F
S
--
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
----
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
----
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
---
C
S
-
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
-
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
----------
53
Blastp_CBE
85.40
79%
-110
- C1 -
-
5OY6
7.2
-
ACVR1_HUMAN
C:
[6-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
--
Q
G
--
E
N
-
V
A
V
K
I
F
S
--
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
----
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
----
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
-
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
-
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
16
PsiBlast_PDB
85.39
78%
-114
- C1 -
-
6SZM
7.8
-
?
A:
[4-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
--
Q
G
--
E
N
-
V
A
V
K
I
F
S
--
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
----
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
----------
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
-
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
-
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
58
Blastp_CBE
85.33
79%
-107
- C1 -
-
4BGG
8.2
-
ACVR1_HUMAN
D:
[6-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
--
Q
G
--
E
N
-
V
A
V
K
I
F
S
--
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
------
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
----
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-------
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
-
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
-
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
14
PsiBlast_PDB
85.32
78%
-108
- C1 -
-
6GIP
7.6
-
ACVR1_HUMAN
A:
[6-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
--
Q
G
--
E
N
-
V
A
V
K
I
F
S
--
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
----
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
-
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
-
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
59
Blastp_CBE
85.26
79%
-109
- C1 -
-
4BGG
8.1
-
ACVR1_HUMAN
C:
[6-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
--
Q
G
--
E
N
-
V
A
V
K
I
F
S
--
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
----
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---------
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
---
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
------------
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
-
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
------------
232
HHSearch
85.22
79%
-112
- C1 -
-
6SRH
8.1
-
ACVR1_HUMAN
A:
[6-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
--
Q
G
--
E
N
-
V
A
V
K
I
F
S
--
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
----
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
-----------
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
-
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
-
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
54
Blastp_CBE
85.21
79%
-111
- C1 -
-
5OY6
6.9
-
ACVR1_HUMAN
B:
[5-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
--
Q
G
--
E
N
-
V
A
V
K
I
F
S
--
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
----
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
----
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
-
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
-
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
109
Blastp_CBE
85.08
63%
-116
- C1 -
-
5USQ
9.0
-
TGFR1_HUMAN
A:
[1-297]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
--
R
G
--
E
E
-
V
A
V
K
I
F
S
--
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
----
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
---
C
S
-
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
-
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
----------
52
Blastp_CBE
85.04
79%
-111
- C1 -
-
5OY6
7.2
-
ACVR1_HUMAN
D:
[6-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
--
Q
G
--
E
N
-
V
A
V
K
I
F
S
--
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
----
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
----
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
-
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
-
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
47
Blastp_CBE
84.99
79%
-114
- C1 -
-
6T6D
7.5
-
?
C:
[7-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
--
Q
G
--
E
N
-
V
A
V
K
I
F
S
--
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
----
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-------------
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
-----------
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
-
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
-
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
46
Blastp_CBE
84.94
79%
-111
- C1 -
-
6T6D
5.9
-
?
D:
[5-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
--
Q
G
--
E
N
-
V
A
V
K
I
F
S
--
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
----
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
-----------
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
-
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
-
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
108
Blastp_CBE
84.80
63%
-113
- C1 -
-
2WOT
9.2
-
TGFR1_HUMAN
A:
[3-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
--
R
G
--
E
E
-
V
A
V
K
I
F
S
--
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
----
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
---
C
S
-
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
-
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
----------
234
HHSearch
84.61
63%
-113
- C1 -
-
5USQ
9.0
-
TGFR1_HUMAN
A:
[3-297]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
--
R
G
--
E
E
-
V
A
V
K
I
F
S
--
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
----
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
---
C
S
-
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
-
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
----------
11
PsiBlast_PDB
84.53
78%
-106
- C1 -
-
5OY6
6.4
-
ACVR1_HUMAN
A:
[6-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
--
Q
G
--
E
N
-
V
A
V
K
I
F
S
--
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
----
L
----
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
----
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
-
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
-
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
99
Blastp_CBE
84.49
63%
-115
- C1 -
-
1RW8
7.3
-
TGFR1_HUMAN
A:
[1-297]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
--
R
G
--
E
E
-
V
A
V
K
I
F
S
--
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
----
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
---
C
S
-
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
-
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
----------
98
Blastp_CBE
84.49
63%
-110
- C1 -
-
5FRI
6.3
-
TGFR1_HUMAN
A:
[3-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
--
R
G
--
E
E
-
V
A
V
K
I
F
S
--
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
----
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
---
C
S
-
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
-
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
----------
91
Blastp_CBE
84.41
63%
-114
- C1 -
-
3TZM
7.6
-
TGFR1_HUMAN
A:
[6-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
--
R
G
--
E
E
-
V
A
V
K
I
F
S
--
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
----
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
--
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
---
C
S
-
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
-
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
----------
100
Blastp_CBE
84.25
63%
-110
- C1 -
-
6B8Y
8.9
-
TGFR1_HUMAN
A:
[4-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
D
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
--
R
G
--
E
E
-
V
A
V
K
I
F
S
--
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
----
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
---
C
S
-
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
-
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
----------
96
Blastp_CBE
84.11
63%
-115
- C1 -
-
4X2F
4.4
-
TGFR1_HUMAN
A:
[2-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
--
R
G
--
E
E
-
V
A
V
K
I
F
S
--
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
----
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
---
C
S
-
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
-
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
----------
97
Blastp_CBE
83.91
63%
-115
- C1 -
-
4X0M
3.2
-
TGFR1_HUMAN
A:
[2-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
--
R
G
--
E
E
-
V
A
V
K
I
F
S
--
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
----
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
---
C
S
-
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
-
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
----------
110
Blastp_CBE
83.86
63%
-115
- C1 -
-
3HMM
8.1
-
TGFR1_HUMAN
A:
[1-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
--
R
G
--
E
E
-
V
A
V
K
I
F
S
--
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
----
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
-----
G
T
K
---
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
---
C
S
-
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
-
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
----------
95
Blastp_CBE
83.72
63%
-114
- C1 -
-
4X2G
3.9
-
TGFR1_HUMAN
A:
[2-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
--
R
G
--
E
E
-
V
A
V
K
I
F
S
--
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
----
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
---
C
S
-
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
-
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
----------
103
Blastp_CBE
83.62
63%
-107
- C1 -
-
5E8Z
6.9
-
TGFR1_HUMAN
A:
[4-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
D
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
--
R
G
--
E
E
-
V
A
V
K
I
F
S
--
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
----
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
---
C
S
-
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
-
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
----------
106
Blastp_CBE
83.58
63%
-112
- C1 -
-
5QIM
7.6
-
TGFR1_HUMAN
A:
[3-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
--
R
G
--
E
E
-
V
A
V
K
I
F
S
--
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
----
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
---
C
S
-
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
-
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
----------
115
Blastp_CBE
83.49
62%
-107
- C1 -
-
5E90
7.0
-
TGFR1_HUMAN
A:
[4-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
D
I
V
L
Q
E
S
V
G
K
G
R
F
G
E
V
W
R
G
K
W
--
R
G
--
E
E
-
V
A
V
K
I
F
S
--
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
F
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
T
D
F
H
E
H
G
N
L
F
D
Y
L
N
----
R
----
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
C
D
F
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
---
C
S
-
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
-
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
----------
94
Blastp_CBE
83.29
63%
-113
- C1 -
-
4X2J
5.6
-
TGFR1_HUMAN
A:
[2-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
--
R
G
--
E
E
-
V
A
V
K
I
F
S
--
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
----
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
---
C
S
-
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
-
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
----------
93
Blastp_CBE
83.29
63%
-113
- C1 -
-
4X2K
5.6
-
TGFR1_HUMAN
A:
[2-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
--
R
G
--
E
E
-
V
A
V
K
I
F
S
--
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
----
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
---
C
S
-
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
-
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
----------
228
HHSearch
83.24
63%
-110
- C1 -
-
4X2J
5.6
-
TGFR1_HUMAN
A:
[4-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
--
R
G
--
E
E
-
V
A
V
K
I
F
S
--
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
----
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
---
C
S
-
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
-
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
--------
101
Blastp_CBE
83.22
63%
-108
- C1 -
-
5QIL
7.3
-
TGFR1_HUMAN
A:
[4-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
D
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
--
R
G
--
E
E
-
V
A
V
K
I
F
S
--
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
----
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
---
C
S
-
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
-
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
----------
104
Blastp_CBE
83.06
63%
-108
- C1 -
-
5E8W
9.0
-
TGFR1_HUMAN
A:
[4-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
D
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
--
R
G
--
E
E
-
V
A
V
K
I
F
S
--
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
----
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
---
C
S
-
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
-
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
----------
105
Blastp_CBE
82.59
63%
-106
- C1 -
-
5E8T
2.5
-
TGFR1_HUMAN
A:
[4-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
D
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
--
R
G
--
E
E
-
V
A
V
K
I
F
S
--
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
----
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
---
C
S
-
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
-
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
----------
102
Blastp_CBE
82.53
63%
-107
- C1 -
-
5QIK
8.0
-
TGFR1_HUMAN
A:
[4-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
D
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
--
R
G
--
E
E
-
V
A
V
K
I
F
S
--
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
----
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
---
C
S
-
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
-
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
----------
66
Blastp_CBE
82.17
63%
-107
- C1 -
-
1PY5
6.2
-
TGFR1_HUMAN
A:
[26-322]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
--
R
G
--
E
E
-
V
A
V
K
I
F
S
--
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
----
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
---
C
S
-
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
-
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
----------
113
Blastp_CBE
81.40
58%
-104
- C1 -
-
3MDY
6.3
-
BMR1B_HUMAN
C:
[11-334]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
D
L
I
E
Q
S
Q
S
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
K
Q
I
Q
M
V
K
Q
I
G
K
G
R
Y
G
E
V
W
M
G
K
W
--
R
G
--
E
K
-
V
A
V
K
V
F
F
--
T
T
E
E
A
S
-----
W
F
R
E
T
E
I
Y
Q
T
V
L
M
R
H
E
N
I
L
G
F
I
A
A
D
-
I
K
G
T
G
S
W
T
Q
L
Y
L
I
T
D
Y
H
E
N
G
S
L
Y
D
Y
L
K
----
S
----
T
T
L
D
A
K
S
M
L
K
L
A
Y
S
S
V
S
G
L
C
H
L
H
T
E
I
-
F
-
S
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
K
F
I
-------
I
P
P
N
T
R
V
G
T
K
---
R
Y
M
P
P
E
V
L
D
E
S
L
N
R
N
H
F
Q
S
Y
I
M
A
D
M
Y
S
F
G
L
I
L
W
E
V
A
R
R
---
C
V
-
S
G
G
I
V
E
E
Y
Q
L
P
Y
H
D
L
V
P
S
D
P
S
Y
E
D
M
R
E
I
V
C
I
K
K
L
R
P
S
F
P
N
R
W
S
S
D
E
C
-
L
R
Q
M
G
K
L
M
T
E
C
W
A
H
N
P
A
S
R
L
T
A
L
R
V
K
K
T
L
A
K
M
S
E
S
Q
D
------
114
Blastp_CBE
81.38
58%
-105
- C1 -
-
3MDY
4.7
-
BMR1B_HUMAN
A:
[11-334]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
D
L
I
E
Q
S
Q
S
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
K
Q
I
Q
M
V
K
Q
I
G
K
G
R
Y
G
E
V
W
M
G
K
W
--
R
G
--
E
K
-
V
A
V
K
V
F
F
--
T
T
E
E
A
S
-----
W
F
R
E
T
E
I
Y
Q
T
V
L
M
R
H
E
N
I
L
G
F
I
A
A
D
-
I
K
G
T
G
S
W
T
Q
L
Y
L
I
T
D
Y
H
E
N
G
S
L
Y
D
Y
L
K
----
S
----
T
T
L
D
A
K
S
M
L
K
L
A
Y
S
S
V
S
G
L
C
H
L
H
T
E
I
-
F
-
S
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
K
F
I
---------
P
N
T
R
V
G
T
K
---
R
Y
M
P
P
E
V
L
D
E
S
L
N
R
N
H
F
Q
S
Y
I
M
A
D
M
Y
S
F
G
L
I
L
W
E
V
A
R
R
---
C
V
-
S
G
G
I
V
E
E
Y
Q
L
P
Y
H
D
L
V
P
S
D
P
S
Y
E
D
M
R
E
I
V
C
I
K
K
L
R
P
S
F
P
N
R
W
S
S
D
E
C
-
L
R
Q
M
G
K
L
M
T
E
C
W
A
H
N
P
A
S
R
L
T
A
L
R
V
K
K
T
L
A
K
M
S
E
S
Q
D
------
111
Blastp_CBE
80.91
63%
-110
- C1 -
-
3GXL
8.1
-
TGFR1_HUMAN
A:
[1-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
-------
E
-
V
A
V
K
I
F
S
--
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
----
R
----
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
-----
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
---
C
S
----
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
--
S
C
E
A
-
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
----------
233
HHSearch
78.90
59%
-107
- C1 -
-
3MDY
4.7
-
BMR1B_HUMAN
A:
[27-333]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
L
V
Q
R
T
I
A
K
Q
I
Q
M
V
K
Q
I
G
K
G
R
Y
G
E
V
W
M
G
K
W
--
R
G
--
E
K
-
V
A
V
K
V
F
F
--
T
T
E
E
A
S
-----
W
F
R
E
T
E
I
Y
Q
T
V
L
M
R
H
E
N
I
L
G
F
I
A
A
D
-
I
K
G
T
G
S
W
T
Q
L
Y
L
I
T
D
Y
H
E
N
G
S
L
Y
D
Y
L
K
----
S
----
T
T
L
D
A
K
S
M
L
K
L
A
Y
S
S
V
S
G
L
C
H
L
H
T
E
I
-
F
-
S
-
T
--
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
K
F
I
---------
P
N
T
R
V
G
T
K
---
R
Y
M
P
P
E
V
L
D
E
S
L
N
R
N
H
F
Q
S
Y
I
M
A
D
M
Y
S
F
G
L
I
L
W
E
V
A
R
R
---
C
V
-
S
G
G
I
V
E
E
Y
Q
L
P
Y
H
D
L
V
P
S
D
P
S
Y
E
D
M
R
E
I
V
C
I
K
K
L
R
P
S
F
P
N
R
W
S
S
D
E
C
-
L
R
Q
M
G
K
L
M
T
E
C
W
A
H
N
P
A
S
R
L
T
A
L
R
V
K
K
T
L
A
K
M
S
E
S
Q
-------
124
Blastp_CBE
65.42
39%
-43
- C1 -
-
2QLU
3.0
-
AVR2B_HUMAN
A:
[17-311]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
L
L
E
I
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
--
M
N
--
D
F
-
V
A
V
K
I
F
P
--
L
Q
D
K
Q
S
-----
W
Q
S
E
R
E
I
F
S
T
P
G
M
K
H
E
N
L
L
Q
F
I
A
A
E
-
K
R
G
S
N
L
E
V
E
L
W
L
I
T
A
F
H
D
K
G
S
L
T
D
Y
L
K
----
G
----
N
I
I
T
W
N
E
L
C
H
V
A
E
T
M
S
R
G
L
S
Y
L
H
E
D
V
-
P
-
W
-
C
--
R
G
EGH
K
P
S
--
I
A
H
R
D
F
K
S
K
N
V
L
L
K
S
D
L
T
A
V
L
A
D
F
G
L
A
V
R
F
E
P
G
K
P
P
G
D
--
T
H
G
Q
V
G
T
R
---
R
Y
M
A
P
E
V
L
E
G
A
I
N
F
Q
-
R
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
V
S
R
C--
K
A
-
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
E
L
Q
E
V
V
V
H
K
K
M
R
P
T
I
K
D
H
W
L
K
H
P
G
-
L
A
Q
L
C
V
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
E
E
R
V
S
L
I
R
R
S
--------
240
HHSearch
64.07
39%
-41
- C1 -
-
4ASX
5.4
-
AVR2A_HUMAN
A:
[23-319]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
P
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
--
L
N
--
E
Y
-
V
A
V
K
I
F
P
--
I
Q
D
K
Q
S
-----
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
E
-
K
R
G
T
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
----
A
----
N
V
V
S
W
N
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
-
P
-
G
-
L
KD
G
H
---
K
P
A
--
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
E
A
G
K
S
A
--
G
-
T
H
G
Q
V
G
T
R
---
R
Y
M
A
P
E
V
L
E
G
A
I
N
F
Q
R
-
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
---
C
T
A
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
Q
K
H
A
G
-
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
L
--------
241
HHSearch
63.29
39%
-40
- C1 -
-
3SOC
6.9
-
AVR2A_HUMAN
A:
[23-319]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
P
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
--
L
N
--
E
Y
-
V
A
V
K
I
F
P
--
I
Q
D
K
Q
S
-----
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
E
-
K
R
G
T
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
----
A
----
N
V
V
S
W
N
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
-
P
-
G
-
L
KD
G
H
---
K
P
A
--
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
E
A
G
K
S
A
--
G
D
T
H
G
Q
V
G
T
R
---
R
Y
M
A
P
E
V
L
E
G
A
I
N
F
Q
R
-
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
---
C
T
A
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
Q
K
H
A
G
-
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
L
--------
235
HHSearch
63.02
36%
-24
- C1 -
-
5E8Y
8.6
-
TGFR2_HUMAN
A:
[9-308]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
I
E
L
D
T
L
V
G
K
G
R
F
A
E
V
Y
K
A
K
L
--
K
Q
QF
E
T
-
V
A
V
K
I
F
P
--
Y
E
E
Y
A
S
-----
W
K
T
E
K
D
I
F
S
D
I
N
L
K
H
E
N
I
L
Q
F
L
T
A
E
-
E
R
K
T
E
L
G
K
Q
Y
W
L
I
T
A
F
H
A
K
G
N
L
Q
E
Y
L
T
----
R
----
H
V
I
S
W
E
D
L
R
K
L
G
S
S
L
A
R
G
I
A
H
L
H
S
D
H
-
T
P
C
-
G
--
R
P
---
K
M
P
--
I
V
H
R
D
L
K
S
S
N
I
L
V
K
N
D
L
T
C
C
L
C
D
F
G
L
S
L
R
L
D
P
T
L
S
V
D
D
L
A
N
S
G
Q
V
G
T
A
---
R
Y
M
A
P
E
V
L
A
S
A
M
N
L
E
N
V
E
S
F
K
Q
T
D
V
Y
S
M
A
L
V
L
W
E
M
T
S
R
---
C
N
-
A
V
G
E
V
K
D
Y
E
P
P
F
G
S
K
V
R
E
H
P
C
V
A
S
M
A
D
N
V
L
A
D
A
G
R
P
E
I
P
S
F
W
L
N
H
Q
G
-
I
Q
M
V
C
E
T
L
T
E
C
W
D
H
D
P
E
A
R
L
T
A
Q
C
V
A
E
R
F
S
E
L
-----------
126
Blastp_CBE
62.43
38%
-34
- C1 -
-
5E92
7.7
-
TGFR2_HUMAN
A:
[11-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
L
D
T
L
V
G
K
G
R
F
A
E
V
Y
K
A
K
L
K--
F
--
E
T
-
V
A
V
K
I
F
P
--
Y
E
E
Y
A
S
-----
W
K
T
E
K
D
I
F
S
D
I
N
L
K
H
E
N
I
L
Q
F
L
T
A
E
-
E
R
K
T
E
L
G
K
Q
Y
W
L
I
T
A
F
H
A
K
G
N
L
Q
E
Y
L
T
----
R
----
H
V
I
S
W
E
D
L
R
K
L
G
S
S
L
A
R
G
I
A
H
L
H
S
D
--
H
-
T
-
P
--
C
G
---
R
P
K
MP
I
V
H
R
D
L
K
S
S
N
I
L
V
K
N
D
L
T
C
C
L
C
D
F
G
L
S
L
R
L
D
P
T
L
S
V
D
D
L
A
N
S
G
Q
V
G
T
A
---
R
Y
M
A
P
E
V
L
A
S
A
M
N
L
E
N
V
E
S
F
K
Q
T
D
V
Y
S
M
A
L
V
L
W
E
M
T
S
R
---
C
N
-
A
V
G
E
V
K
D
Y
E
P
P
F
G
S
K
V
R
E
H
P
C
V
A
S
M
A
D
N
V
L
A
D
A
G
R
P
E
I
P
S
F
W
L
N
H
Q
G
-
I
Q
M
V
C
E
T
L
T
E
C
W
D
H
D
P
E
A
R
L
T
A
---------------------
238
HHSearch
61.88
36%
-19
- C1 -
-
5QIN
7.8
-
TGFR2_HUMAN
A:
[9-308]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
I
E
L
D
T
L
V
G
K
G
R
F
A
E
V
Y
K
A
K
L
--
K
-QF
E
T
-
V
A
V
K
I
F
P
--
Y
E
E
Y
A
S
-----
W
K
T
E
K
D
I
F
S
D
I
N
L
K
H
E
N
I
L
Q
F
L
T
A
E
-
E
R
K
T
E
L
G
K
Q
Y
W
L
I
T
A
F
H
A
K
G
N
L
Q
E
Y
L
T
----
R
----
H
V
I
S
W
E
D
L
R
K
L
G
S
S
L
A
R
G
I
A
H
L
H
S
D
H
-
T
-
P
C
G
--
R
P
---
K
M
P
--
I
V
H
R
D
L
K
S
S
N
I
L
V
K
N
D
L
T
C
C
L
C
D
F
G
L
S
L
R
L
D
P
T
L
S
V
D
D
L
A
N
--
Q
V
G
T
A
---
R
Y
M
A
P
E
V
L
A
S
A
M
N
L
E
N
V
E
S
F
K
Q
T
D
V
Y
S
M
A
L
V
L
W
E
M
T
S
R
---
C
N
-
A
V
G
E
V
K
D
Y
E
P
P
F
G
S
K
V
R
E
H
P
C
V
A
S
M
A
D
N
V
L
A
D
A
G
R
P
E
I
P
S
F
W
L
N
H
Q
G
-
I
Q
M
V
C
E
T
L
T
E
C
W
D
H
D
P
E
A
R
L
T
A
Q
C
V
A
E
R
F
S
E
L
-----------
127
Blastp_CBE
61.39
38%
-33
- C1 -
-
5E91
6.5
-
TGFR2_HUMAN
A:
[11-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
L
D
T
L
V
G
K
G
R
F
A
E
V
Y
K
A
K
L
K-----
E
T
-
V
A
V
K
I
F
P
--
Y
E
E
Y
A
S
-----
W
K
T
E
K
D
I
F
S
D
I
N
L
K
H
E
N
I
L
Q
F
L
T
A
E
-
E
R
K
T
E
L
G
K
Q
Y
W
L
I
T
A
F
H
A
K
G
N
L
Q
E
Y
L
T
----
R
----
H
V
I
S
W
E
D
L
R
K
L
G
S
S
L
A
R
G
I
A
H
L
H
S
D
--
H
-
T
-
P
--
C
G
---
R
P
K
MP
I
V
H
R
D
L
K
S
S
N
I
L
V
K
N
D
L
T
C
C
L
C
D
F
G
L
S
L
R
L
D
P
T
L
S
V
D
D
L
A
N
S
G
Q
V
G
T
A
---
R
Y
M
A
P
E
V
L
A
S
A
M
N
L
E
N
V
E
S
F
K
Q
T
D
V
Y
S
M
A
L
V
L
W
E
M
T
S
R
---
C
N
-
A
V
G
E
V
K
D
Y
E
P
P
F
G
S
K
V
R
E
H
P
C
V
A
S
M
A
D
N
V
L
A
D
A
G
R
P
E
I
P
S
F
W
L
N
H
Q
G
-
I
Q
M
V
C
E
T
L
T
E
C
W
D
H
D
P
E
A
R
L
T
A
---------------------
118
Blastp_CBE
60.85
41%
-32
- C1 -
-
4ASX
5.4
-
AVR2A_HUMAN
B:
[28-306]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
--
L
N
--
E
Y
-
V
A
V
K
I
F
P
--
I
Q
D
K
Q
S
-----
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
E
-
K
R
G
T
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
----
A
----
N
V
V
S
W
N
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
-
P
-
G
-
L
--
K
D
GH-
K
P
A
--
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
E
A
G
K
S
A
G
D
--
T
H
G
Q
V
G
T
R
---
R
Y
M
A
P
E
V
L
E
G
A
I
N
F
Q
-
R
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C--
T
A
-
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
Q
K
H
A
G
-
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
---------------------
125
Blastp_CBE
60.50
38%
-28
- C1 -
-
5QIN
7.8
-
TGFR2_HUMAN
A:
[11-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
L
D
T
L
V
G
K
G
R
F
A
E
V
Y
K
A
K
L
K-
Q
F
--
E
T
-
V
A
V
K
I
F
P
--
Y
E
E
Y
A
S
-----
W
K
T
E
K
D
I
F
S
D
I
N
L
K
H
E
N
I
L
Q
F
L
T
A
E
-
E
R
K
T
E
L
G
K
Q
Y
W
L
I
T
A
F
H
A
K
G
N
L
Q
E
Y
L
T
----
R
----
H
V
I
S
W
E
D
L
R
K
L
G
S
S
L
A
R
G
I
A
H
L
H
S
D
--
H
-
T
-
P
--
C
G
---
R
P
K
MP
I
V
H
R
D
L
K
S
S
N
I
L
V
K
N
D
L
T
C
C
L
C
D
F
G
L
S
L
R
L
D
P
T
L
S
V
D
D
L
A
N
--
Q
V
G
T
A
---
R
Y
M
A
P
E
V
L
A
S
A
M
N
L
E
N
V
E
S
F
K
Q
T
D
V
Y
S
M
A
L
V
L
W
E
M
T
S
R
---
C
N
-
A
V
G
E
V
K
D
Y
E
P
P
F
G
S
K
V
R
E
H
P
C
V
A
S
M
A
D
N
V
L
A
D
A
G
R
P
E
I
P
S
F
W
L
N
H
Q
G
-
I
Q
M
V
C
E
T
L
T
E
C
W
D
H
D
P
E
A
R
L
T
A
---------------------
123
Blastp_CBE
59.62
41%
-31
- C1 -
-
3Q4T
4.7
-
AVR2A_HUMAN
A:
[28-306]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
--
L
N
--
E
Y
-
V
A
V
K
I
F
P
--
I
Q
D
K
Q
S
-----
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
E
-
K
R
G
T
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
----
A
----
N
V
V
S
W
N
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
-
P
-
G
-
L
--
K
D
GH-
K
P
A
--
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
E
A
G
K
S
A
G
D
--
T
H
G
Q
V
G
T
R
---
R
Y
M
A
P
E
V
L
E
G
A
I
N
F
Q
-
R
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C--
T
A
-
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
Q
K
H
A
G
-
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
---------------------
120
Blastp_CBE
58.93
41%
-34
- C1 -
-
3SOC
7.0
-
AVR2A_HUMAN
B:
[28-306]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
--
L
N
--
E
Y
-
V
A
V
K
I
F
P
--
I
Q
D
K
Q
S
-----
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
E
-
K
R
G
T
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
----
A
----
N
V
V
S
W
N
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
-
P
-
G
-
L
--
K
D
GH-
K
P
A
--
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
E
A
G
K
S
A
----
T
H
G
Q
V
G
T
R
---
R
Y
M
A
P
E
V
L
E
G
A
I
N
F
Q
-
R
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C--
T
A
-
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
Q
K
H
A
G
-
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
---------------------
119
Blastp_CBE
58.55
41%
-30
- C1 -
-
4ASX
5.4
-
AVR2A_HUMAN
A:
[28-306]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
--
L
N
--
E
Y
-
V
A
V
K
I
F
P
--
I
Q
D
K
Q
S
-----
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
E
-
K
R
G
T
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
----
A
----
N
V
V
S
W
N
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
-
P
-
G
-
L
--
K
D
GH-
K
P
A
--
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
E
A
G
K
S
A
G
---
T
H
G
Q
V
G
T
R
---
R
Y
M
A
P
E
V
L
E
G
A
I
N
F
Q
-
R
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C--
T
A
-
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
Q
K
H
A
G
-
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
---------------------
122
Blastp_CBE
58.45
41%
-30
- C1 -
-
3Q4T
5.9
-
AVR2A_HUMAN
B:
[28-306]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
--
L
N
--
E
Y
-
V
A
V
K
I
F
P
--
I
Q
D
K
Q
S
-----
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
E
-
K
R
G
T
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
----
A
----
N
V
V
S
W
N
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
-
P
-
G
-
L
--
K
D
GH-
K
P
A
--
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
E
A
G
K
S
A
----
T
H
G
Q
V
G
T
R
---
R
Y
M
A
P
E
V
L
E
G
A
I
N
F
Q
-
R
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C--
T
A
-
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
Q
K
H
A
G
-
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
---------------------
121
Blastp_CBE
57.42
41%
-29
- C1 -
-
3SOC
6.9
-
AVR2A_HUMAN
A:
[28-306]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
--
L
N
--
E
Y
-
V
A
V
K
I
F
P
--
I
Q
D
K
Q
S
-----
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
E
-
K
R
G
T
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
----
A
----
N
V
V
S
W
N
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
-
P
-
G
-
L
--
K
D
GH-
K
P
A
--
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
E
A
G
K
S
A
G
D
--
T
H
G
Q
V
G
T
R
---
R
Y
M
A
P
E
V
L
E
G
A
I
N
F
Q
-
R
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C--
T
A
-
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
Q
K
H
A
G
-
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
---------------------
128
Blastp_CBE
56.24
38%
-3
- C1 -
-
5E8Y
8.6
-
TGFR2_HUMAN
A:
[11-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
L
D
T
L
V
G
K
G
R
F
A
E
V
Y
K
A
K
L
KQ
Q
F
--
E
T
-
V
A
V
K
I
F
P
--
Y
E
E
Y
A
S
-----
W
K
T
E
K
D
I
F
S
D
I
N
L
K
H
E
N
I
L
Q
F
L
T
A
E
-
E
R
K
T
E
L
G
K
Q
Y
W
L
I
T
A
F
H
A
K
G
N
L
Q
E
Y
L
T
----
R
----
H
V
I
S
W
E
D
L
R
K
L
G
S
S
L
A
R
G
I
A
H
L
H
S
D
--
H
-
T
-
P
--
C
G
---
R
P
K
MP
I
V
H
R
D
L
K
S
S
N
I
L
V
K
N
D
L
T
C
C
L
C
D
F
G
L
S
L
R
L
D
P
T
L
S
V
D
D
L
A
N
S
G
Q
V
G
T
A
---
R
Y
M
A
P
E
V
L
A
S
A
M
N
L
E
N
V
E
S
F
K
Q
T
D
V
Y
S
M
A
L
V
L
W
E
M
T
S
R
---
C
N
-
A
V
G
E
V
K
D
Y
E
P
P
F
G
S
K
V
R
E
H
P
C
V
A
S
M
A
D
N
V
L
A
D
A
G
R
P
E
I
P
S
F
W
L
N
H
Q
G
-
I
Q
M
V
C
E
T
L
T
E
C
W
D
H
D
P
E
A
R
L
T
A
---------------------
130
Blastp_CBE
53.01
37%
-39
- C1 -
-
3G2F
6.1
-
BMPR2_HUMAN
B:
[14-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
K
L
L
E
L
I
G
R
G
R
Y
G
A
V
Y
K
G
S
L
--
D
E
--
R
P
-
V
A
V
K
V
F
S
--
F
A
N
R
Q
N
-----
F
I
N
E
K
N
I
Y
R
V
P
L
M
E
H
D
N
I
A
R
F
I
V
G
D
E
R
V
T
A
D
G
R
M
E
Y
L
L
V
M
E
Y
Y
P
N
G
S
L
C
K
Y
L
S
----
L
----
H
T
S
D
W
V
S
S
C
R
L
A
H
S
V
T
R
G
L
A
Y
L
H
T
E
L
P
R
-
G
-
D
--
H
Y
---
K
P
A
--
I
S
H
R
D
L
N
S
R
N
V
L
V
K
N
D
G
T
C
V
I
S
D
F
G
L
S
-
M
R
L
T
G
N
R
L
--------
V
G
T
I
---
R
Y
M
A
P
E
V
L
E
G
A
V
N
L
R
D
E
S
A
L
K
Q
V
D
M
Y
A
L
G
L
I
Y
W
E
I
F
M
R
CTD
L
F
-
P
G
E
S
V
P
E
Y
Q
M
A
F
Q
T
E
V
G
N
H
P
T
F
E
D
M
Q
V
L
V
S
R
E
K
Q
R
P
K
F
P
E
A
W
K
E
N
S
L
A
V
R
S
L
K
E
T
I
E
D
C
W
D
Q
D
A
E
A
R
L
T
A
---------------------
131
Blastp_CBE
52.58
37%
-39
- C1 -
-
3G2F
6.3
-
BMPR2_HUMAN
A:
[14-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
K
L
L
E
L
I
G
R
G
R
Y
G
A
V
Y
K
G
S
L
--
D
E
--
R
P
-
V
A
V
K
V
F
S
--
F
A
N
R
Q
N
-----
F
I
N
E
K
N
I
Y
R
V
P
L
M
E
H
D
N
I
A
R
F
I
V
G
D
E
R
V
T
A
D
G
R
M
E
Y
L
L
V
M
E
Y
Y
P
N
G
S
L
C
K
Y
L
S
----
L
----
H
T
S
D
W
V
S
S
C
R
L
A
H
S
V
T
R
G
L
A
Y
L
H
T
E
L
P
R
-
G
-
D
--
H
Y
---
K
P
A
--
I
S
H
R
D
L
N
S
R
N
V
L
V
K
N
D
G
T
C
V
I
S
D
F
G
L
S
-
M
R
L
T
G
N
R
L
V
R
P
----
E
V
G
T
I
---
R
Y
M
A
P
E
V
L
E
G
A
V
N
L
R
D
E
S
A
L
K
Q
V
D
M
Y
A
L
G
L
I
Y
W
E
I
F
M
R
CTD
L
F
-
P
G
E
S
V
P
E
Y
Q
M
A
F
Q
T
E
V
G
N
H
P
T
F
E
D
M
Q
V
L
V
S
R
E
K
Q
R
P
K
F
P
E
A
W
K
E
N
S
L
A
V
R
S
L
K
E
T
I
E
D
C
W
D
Q
D
A
E
A
R
L
T
A
---------------------
143
Blastp_CBE
37.04
31%
-54
- C1 -
-
5XY1
5.1
-
A:
[14-203]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
L
V
K
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
N
--
S
T
K
V
A
V
K
T
L
K
PG
T
M
S
V
Q
A
-----
F
L
E
E
A
N
L
M
K
T
--
L
Q
H
D
K
L
V
R
L
Y
A
---
V
V
T
R
E
E
P
--
I
Y
I
I
T
E
Y
M
A
K
G
S
L
L
D
F
L
K
----
S
DEGG
K
V
L
L
P
K
L
-
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
----------------
R
K
N
--
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
------------------
K
FPI
K
W
T
A
P
E
A
----
I
N
F
G
C
F
T
I
K
--
S
D
V
W
S
F
G
I
L
L
Y
E
I
----------------------------------------------------------------------------------------------------
144
Blastp_CBE
34.94
31%
-53
- C1 -
-
3A4O
6.2
-
X:
[15-204]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
L
V
K
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
N
--
S
T
K
V
A
V
K
T
L
K
PG
T
M
S
V
Q
A
-----
F
L
E
E
A
N
L
M
K
T
--
L
Q
H
D
K
L
V
R
L
Y
A
---
V
V
T
R
E
E
P
--
I
Y
I
I
T
E
Y
M
A
K
G
S
L
L
D
F
L
K
----
S
DEGG
K
V
L
L
P
K
L
-
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
----------------
R
K
N
--
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
---------------
E
G
A
K
FPI
K
W
T
A
P
E
A
----
I
N
F
G
C
F
T
I
K
--
S
D
V
W
S
F
G
I
L
L
Y
E
I
----------------------------------------------------------------------------------------------------
133
Blastp_CBE
32.94
33%
-29
- C1 -
-
3PPZ
8.0
-
CTR1_ARATH
A:
[43-233]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
G
A
G
S
F
G
T
V
H
R
A
E
W
--
H
G
--
S
D
-
V
A
V
K
I
L
M
--
E
----
A
ERVNE
F
L
R
E
V
A
I
M
K
R
--
L
R
H
P
N
I
V
L
F
M
G
A
V
-
T
Q
P
P
N
L
S
----
I
V
T
E
Y
L
S
R
G
S
L
Y
R
L
L
H
KSGA
R
----
E
Q
L
D
E
R
R
R
L
S
M
A
Y
D
V
A
K
G
M
N
Y
L
H
-----------
N
R
---
N
P
P
--
I
V
H
R
D
L
K
S
P
N
L
L
V
D
K
K
Y
T
V
K
V
C
D
F
G
L
S
R
L
K
A
S
T
--
F
L
S
K
A
----
A
G
T
P
---
E
W
M
A
P
E
V
L
R
D
E
------
P
S
N
E
K
S
D
V
Y
S
F
G
V
I
L
W
E
L
A
---------------------------------------------------------------------------------------------------