@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Screening
Virtual Screening Score
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ACVR1_HUMAN: (2020-09-04 )
MVDGVMILPVLIMIALPSPSMEDEKPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSINDGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLPTKGKSFPGTQNFHLEVGLIILSVVFAVCLLACLLGVALRKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC
Atome Classification :
(93 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220...----....--230.......240..-----.....250.......260...--....-270.......280.......290......----.300....-...310.......320.-.-.--...---.330-........340.......350.......360...----....370.......380.......390.......400.......410.-....---..420.......430...-----------.-----------...440.......450...---....460...-....470.......480.......490.......500.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(pKd)
(pKd)
(Uniprot)
MVD
G
V
M
I
L
P
V
L
I
M
IALPSPSMEDEKPKVNP
K
L
Y
M
C
V
CEGLSCGNEDHC
E
G
Q
Q
C
F
S
SLSIND
G
F
H
V
Y
Q
K
G
C
F
Q
V
Y
E
QGK
M
T
CKTPPSPGQ
A
V
ECCQGDWCNRNITAQLPTKGKSFPGTQ
N
F
H
L
E
V
G
L
I
I
L
S
V
V
F
A
V
C
L
L
A
C
L
L
G
V
A
L
R
K
F
K
R
R
N
Q
ERLNPRDVEYGTI
E
G
L
I
TTNVG
D
S
T
L
A
D
L
L
DHSCTSGSGSG
L
P
F
L
V
Q
R
T
V
A
R
Q
I
T
L
L
E
C
VGKGRYGEVWRG----SWQG--
E
N
V
A
V
K
I
F
SSRD
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
RH
E
N
I
L
G
F
--
I
A
S
D
-
M
TSRHSS
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
LT----TL
D
T
V
S
C
L
-
R
I
V
L
S
I
ASG
L
A
H
L
H
I
E
I
-
F
-G--TQG---KP
A
--
I
AHRDLKSK
N
I
L
V
KKNG
Q
C
C
I
A
D
L
G
L
A
V
MHSQST----NQLDVGNNPRVGTKRYM
A
P
E
V
L
D
E
T
I
Q
V
D
CFDSYKR
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
---
M
V
SNGIVEDYKPP
F
Y
DVV-----------P-----------NDP
S
F
E
D
M
R
K
V
V
CVDQQRP---NIPNRWFSDP-
T
L
T
S
L
A
K
L
M
K
E
C
WYQNPSA
R
L
T
A
L
R
I
K
K
T
L
T
K
I
D
N
S
L
D
K
LKTDC
3
PsiBlast_PDB
95.66
99%
-116
- C1 -
-
4C02
7.1
-
ACVR1_HUMAN
A:
[9-330]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
L
A
D
L
L
D
----
S
G
S
G
S
G
L
P
F
L
V
Q
R
T
V
A
R
Q
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
----
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
S
D
-
M
T
S
R
--
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
----
T
L
D
T
V
S
C
L
-
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
----
N
Q
L
D
V
---
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
-----------
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
---
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
D
----------
4
PsiBlast_PDB
94.54
99%
-108
- C1 -
-
6I1S
7.8
-
ACVR1_HUMAN (first)
A:
[2-330]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
T
N
V
G
D
S
T
L
A
D
L
L
D
H
-----
S
G
S
G
L
P
F
L
V
Q
R
T
V
A
R
Q
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
----
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
S
D
-
M
T
---
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
----
T
L
D
T
V
S
C
L
-
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
----
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
-----------
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
---
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
D
----------
1
PsiBlast_PDB
94.17
99%
-101
- C1 -
-
6EIX
7.1
-
ACVR1_HUMAN
A:
[23-334]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
S
G
L
P
F
L
V
Q
R
T
V
A
R
E
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
----
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
----
T
L
D
T
V
S
C
L
-
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
----
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
-----------
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
---
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
D
N
S
L
D
------
2
PsiBlast_PDB
93.81
99%
-113
- C1 -
-
3H9R
7.8
-
ACVR1_HUMAN
A:
[3-330]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
N
V
G
D
S
T
L
A
D
L
L
D
H
S
C
T
S
G
S
G
S
G
L
P
F
L
V
Q
R
T
V
A
R
Q
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
----
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
S
D
-
M
T
---
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
----
T
L
D
T
V
S
C
L
-
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
-----------------
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
-----------
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
---
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
D
----------
34
Blastp_CBE
92.44
99%
-103
- C1 -
-
5OXG
8.5
-
ACVR1_HUMAN
C:
[2-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
Q
R
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
----
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
----
T
L
D
T
V
S
C
L
-
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
----
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
-----------
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
---
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
D
----------
41
Blastp_CBE
92.23
99%
-113
- C1 -
-
3Q4U
8.8
-
ACVR1_HUMAN
B:
[2-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
Q
R
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
----
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
----
T
L
D
T
V
S
C
L
-
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
----
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
-----------
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
---
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
39
Blastp_CBE
92.06
99%
-106
- C1 -
-
3Q4U
-
-
ACVR1_HUMAN
D:
[3-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
R
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
----
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
----
T
L
D
T
V
S
C
L
-
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
----
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
-----------
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
---
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
D
----------
165
HHSearch
91.40
100%
-105
- C1 -
-
5OXG
8.5
-
ACVR1_HUMAN
C:
[6-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
----
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
----
T
L
D
T
V
S
C
L
-
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
----
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
-----------
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
---
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
27
Blastp_CBE
91.30
99%
-109
- C1 -
-
6SRH
8.1
-
ACVR1_HUMAN
B:
[7-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
----
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
----
T
L
D
T
V
S
C
L
-
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
----
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
-----------
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
---
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
D
----------
42
Blastp_CBE
91.19
99%
-110
- C1 -
-
3MTF
-
-
ACVR1_HUMAN
B:
[4-301]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
----
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
----
T
L
D
T
V
S
C
L
-
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
----
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
-----------
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
---
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
D
----------
12
PsiBlast_PDB
90.69
99%
-110
- C1 -
-
6GIN
8.7
-
ACVR1_HUMAN
A:
[6-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
----
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
----
T
L
D
T
V
S
C
L
-
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
----
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
-----------
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
---
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
D
----------
6
PsiBlast_PDB
90.58
99%
-108
- C1 -
-
3OOM
7.5
-
ACVR1_HUMAN
A:
[5-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
----
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
----
T
L
D
T
V
S
C
L
-
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
----
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
-----------
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
---
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
D
----------
25
Blastp_CBE
90.49
99%
-108
- C1 -
-
6T6D
7.2
-
?
B:
[5-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
----
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
----
T
L
D
T
V
S
C
L
-
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
----
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
-----------
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
---
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
D
----------
19
PsiBlast_PDB
90.41
99%
-110
- C1 -
-
6ACR
7.0
-
ACVR1_HUMAN
A:
[5-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
H
Q
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
----
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
----
T
L
D
T
V
S
C
L
-
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
----
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
----
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
-----------
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
---
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
7
PsiBlast_PDB
90.31
99%
-107
- C1 -
-
3Q4U
8.6
-
ACVR1_HUMAN
A:
[4-301]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
----
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
----
T
L
D
T
V
S
C
L
-
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
----
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
-----------
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
---
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
D
----------
40
Blastp_CBE
90.30
99%
-105
- C1 -
-
3Q4U
8.9
-
ACVR1_HUMAN
C:
[6-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
----
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
----
T
L
D
T
V
S
C
L
-
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
----
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
-----------
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
---
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
D
----------
16
PsiBlast_PDB
90.23
99%
-115
- C1 -
-
6T6D
7.5
-
?
A:
[6-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
----
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
----
T
L
D
T
V
S
C
L
-
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
----
N
-
L
D
V
---
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
-----------
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
---
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
D
----------
35
Blastp_CBE
90.20
99%
-106
- C1 -
-
5OXG
8.5
-
ACVR1_HUMAN
B:
[5-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
----
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
----
T
L
D
T
V
S
C
L
-
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
----
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
-----------
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
---
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
26
Blastp_CBE
90.16
99%
-105
- C1 -
-
6SZM
7.8
-
?
B:
[7-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
----
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
----
T
L
D
T
V
S
C
L
-
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
----
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
-----------
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
---
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
D
----------
5
PsiBlast_PDB
90.07
99%
-107
- C1 -
-
3MTF
7.5
-
ACVR1_HUMAN
A:
[5-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
----
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
----
T
L
D
T
V
S
C
L
-
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
----
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
-----------
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
---
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
29
Blastp_CBE
89.97
99%
-107
- C1 -
-
6ACR
7.2
-
ACVR1_HUMAN
B:
[5-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
H
Q
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
----
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
----
T
L
D
T
V
S
C
L
-
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
------
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
----
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
-----------
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
---
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
38
Blastp_CBE
89.78
99%
-108
- C1 -
-
4BGG
8.2
-
ACVR1_HUMAN
B:
[5-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
----
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
----
T
L
D
T
V
S
C
L
-
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
------
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
----
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
-----------
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
---
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
28
Blastp_CBE
89.76
99%
-109
- C1 -
-
6GIN
8.1
-
ACVR1_HUMAN
B:
[6-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
----
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
----
T
L
D
T
V
S
C
L
-
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
----
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
-----------
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
---
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
D
----------
9
PsiBlast_PDB
89.75
99%
-108
- C1 -
-
5OXG
8.4
-
ACVR1_HUMAN
A:
[5-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
----
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
S
D
-
M
T
S
---
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
----
T
L
D
T
V
S
C
L
-
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
----
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
-----------
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
---
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
22
Blastp_CBE
89.71
99%
-104
- C1 -
-
6T8N
8.7
-
?
B:
[5-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
----
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
S
D
-
M
T
S
----
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
----
T
L
D
T
V
S
C
L
-
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
----
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
-----------
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
---
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
D
----------
18
PsiBlast_PDB
89.58
99%
-108
- C1 -
-
4DYM
6.5
-
ACVR1_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
----
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
----
T
L
D
T
V
S
C
L
-
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
----
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
-----------
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
---
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
D
----------
17
PsiBlast_PDB
89.55
99%
-108
- C1 -
-
6T8N
8.1
-
?
A:
[5-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
----
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
S
D
-
M
T
S
---
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
----
T
L
D
T
V
S
C
L
-
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
----
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
-----------
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
---
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
8
PsiBlast_PDB
89.53
99%
-106
- C1 -
-
4BGG
8.0
-
ACVR1_HUMAN
A:
[5-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
----
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
----
T
L
D
T
V
S
C
L
-
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
----
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
-----------
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
---
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
11
PsiBlast_PDB
89.37
99%
-108
- C1 -
-
6GI6
6.7
-
ACVR1_HUMAN
A:
[4-301]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
----
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
----
T
L
D
T
V
S
C
L
-
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
----
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
-----------
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
---
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
D
----------
33
Blastp_CBE
89.19
99%
-106
- C1 -
-
5OXG
8.6
-
ACVR1_HUMAN
D:
[6-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
----
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
S
D
-
M
T
---
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
----
T
L
D
T
V
S
C
L
-
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
----
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
-----------
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
---
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
D
----------
21
Blastp_CBE
88.69
99%
-105
- C1 -
-
6TN8
6.0
-
?
A:
[6-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
----
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
----
T
L
D
T
V
S
C
L
-
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
----
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
-----------
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
---
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
D
----------
167
HHSearch
88.58
100%
-114
- C1 -
-
6SRH
8.0
-
ACVR1_HUMAN
A:
[6-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
----
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
----
T
L
D
T
V
S
C
L
-
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
---------------
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
-----------
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
---
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
14
PsiBlast_PDB
88.55
99%
-112
- C1 -
-
6SRH
8.0
-
ACVR1_HUMAN
A:
[3-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
R
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
----
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
----
T
L
D
T
V
S
C
L
-
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
---------------
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
-----------
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
---
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
D
----------
13
PsiBlast_PDB
88.27
99%
-106
- C1 -
-
6GIP
7.6
-
ACVR1_HUMAN
A:
[6-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
----
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
----
T
L
D
T
V
S
C
L
-
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
----
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
-----------
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
---
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
D
----------
32
Blastp_CBE
88.18
99%
-112
- C1 -
-
5OY6
6.9
-
ACVR1_HUMAN
B:
[5-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
----
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
----
T
L
D
T
V
S
C
L
-
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
--------
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
-----------
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
---
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
36
Blastp_CBE
88.05
99%
-108
- C1 -
-
4BGG
8.1
-
ACVR1_HUMAN
D:
[6-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
----
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
S
D
-
M
------
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
----
T
L
D
T
V
S
C
L
-
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
------
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
----
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
-----------
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
---
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
23
Blastp_CBE
88.00
99%
-112
- C1 -
-
6T6D
5.9
-
?
D:
[5-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
----
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
----
T
L
D
T
V
S
C
L
-
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
---------------
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
-----------
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
---
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
31
Blastp_CBE
87.67
99%
-110
- C1 -
-
5OY6
7.2
-
ACVR1_HUMAN
C:
[6-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
----
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
----
T
L
D
T
V
S
C
L
-
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
--------
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
-----------
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
---
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
116
Blastp_CBE
87.63
65%
-125
- C1 -
-
5E8X
8.6
-
TGFR1_HUMAN
A:
[4-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
D
I
V
L
Q
E
S
V
G
K
G
R
F
G
E
V
W
R
G
----
K
W
R
G
--
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
F
Q
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
T
D
F
H
E
H
G
N
L
F
D
Y
L
N
R
Y
----
T
V
T
V
E
G
M
I
-
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
C
D
F
G
L
A
V
R
H
D
S
A
T
----
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
-
I
A
R
R
---
C
S
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
-----------
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
---
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
-----------
30
Blastp_CBE
87.58
99%
-109
- C1 -
-
5OY6
7.2
-
ACVR1_HUMAN
D:
[6-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
----
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
----
T
L
D
T
V
S
C
L
-
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
--------
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
-----------
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
---
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
D
----------
163
HHSearch
87.34
64%
-121
- C1 -
-
5E8X
8.6
-
TGFR1_HUMAN
A:
[5-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
R
D
I
V
L
Q
E
S
V
G
K
G
R
F
G
E
V
W
R
G
----
K
W
R
G
--
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
F
Q
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
T
D
F
H
E
H
G
N
L
F
D
Y
L
N
R
Y
----
T
V
T
V
E
G
M
I
-
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
C
D
F
G
L
A
V
R
H
D
S
A
T
----
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
-
I
A
R
R
---
C
S
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
-----------
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
---
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
------
37
Blastp_CBE
87.22
99%
-111
- C1 -
-
4BGG
8.1
-
ACVR1_HUMAN
C:
[6-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
----
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
----
T
L
D
T
V
S
C
L
-
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
--------
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
----
N
---
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
-----------
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
-----------
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
---
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
------------
15
PsiBlast_PDB
86.85
99%
-112
- C1 -
-
6SZM
7.7
-
?
A:
[4-301]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
----
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
----
T
L
D
T
V
S
C
L
-
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
--------------
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
-----------
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
---
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
D
----------
10
PsiBlast_PDB
86.76
99%
-106
- C1 -
-
5OY6
6.4
-
ACVR1_HUMAN
A:
[6-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
----
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
----
T
L
D
T
V
S
C
L
-
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-
F
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
--------
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
-----------
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
---
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
24
Blastp_CBE
86.48
99%
-115
- C1 -
-
6T6D
7.5
-
?
C:
[7-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
----
S
W
Q
G
--
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
-----
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
----
T
L
D
T
V
S
C
L
-
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
------------
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
---------------
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
-----------
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
---
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
107
Blastp_CBE
85.42
66%
-116
- C1 -
-
2WOU
6.4
-
TGFR1_HUMAN
A:
[3-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
----
K
W
R
G
--
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
----
T
V
T
V
E
G
M
I
-
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
----
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
-
I
A
R
R
---
C
S
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
-----------
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
---
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
-----------
108
Blastp_CBE
85.11
66%
-115
- C1 -
-
2WOT
9.2
-
TGFR1_HUMAN
A:
[3-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
----
K
W
R
G
--
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
----
T
V
T
V
E
G
M
I
-
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
----
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
-
I
A
R
R
---
C
S
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
-----------
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
---
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
-----------
111
Blastp_CBE
84.67
66%
-111
- C1 -
-
5FRI
6.3
-
TGFR1_HUMAN
A:
[3-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
----
K
W
R
G
--
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
----
T
V
T
V
E
G
M
I
-
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
----
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
-
I
A
R
R
---
C
S
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
-----------
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
---
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
-----------
109
Blastp_CBE
84.64
66%
-117
- C1 -
-
5USQ
9.0
-
TGFR1_HUMAN
A:
[1-296]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
----
K
W
R
G
--
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
----
T
V
T
V
E
G
M
I
-
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
----
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
-
I
A
R
R
---
C
S
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
-----------
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
---
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
-----------
93
Blastp_CBE
84.60
66%
-115
- C1 -
-
3TZM
7.6
-
TGFR1_HUMAN
A:
[6-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
----
K
W
R
G
--
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
----
T
V
T
V
E
G
M
I
-
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
----
D
T
I
D
I
A
P
--
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
-
I
A
R
R
---
C
S
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
-----------
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
---
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
-----------
114
Blastp_CBE
84.54
66%
-115
- C1 -
-
1VJY
7.2
-
TGFR1_HUMAN
A:
[1-295]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
----
K
W
R
G
--
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
----
T
V
T
V
E
G
M
I
-
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
----
D
T
I
D
I
----
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
-
I
A
R
R
---
C
S
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
-----------
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
---
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
-----------
170
HHSearch
84.22
66%
-113
* C1 *
-
5USQ
9.0
-
TGFR1_HUMAN
A:
[3-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
----
K
W
R
G
--
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
----
T
V
T
V
E
G
M
I
-
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
----
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
-
I
A
R
R
---
C
S
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
-----------
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
---
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
---------
94
Blastp_CBE
84.03
66%
-112
- C1 -
-
6B8Y
8.9
-
TGFR1_HUMAN
A:
[4-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
D
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
----
K
W
R
G
--
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
----
T
V
T
V
E
G
M
I
-
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
----
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
-
I
A
R
R
---
C
S
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
-----------
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
---
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
-----------
97
Blastp_CBE
84.02
66%
-109
- C1 -
-
5E8Z
6.8
-
TGFR1_HUMAN
A:
[4-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
D
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
----
K
W
R
G
--
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
----
T
V
T
V
E
G
M
I
-
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
----
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
-
I
A
R
R
---
C
S
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
-----------
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
---
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
-----------
112
Blastp_CBE
83.91
66%
-116
- C1 -
-
3HMM
8.1
-
TGFR1_HUMAN
A:
[1-295]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
----
K
W
R
G
--
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
----
T
V
T
V
E
G
M
I
-
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
----
D
T
I
D
I
A
-----
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
-
I
A
R
R
---
C
S
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
-----------
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
---
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
-----------
105
Blastp_CBE
83.46
66%
-115
- C1 -
-
4X0M
3.2
-
TGFR1_HUMAN
A:
[2-297]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
----
K
W
R
G
--
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
----
T
V
T
V
E
G
M
I
-
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
----
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
-
I
A
R
R
---
C
S
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
-----------
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
---
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
-----------
106
Blastp_CBE
83.39
66%
-114
- C1 -
-
5QIM
7.6
-
TGFR1_HUMAN
A:
[3-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
----
K
W
R
G
--
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
----
T
V
T
V
E
G
M
I
-
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
----
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
-
I
A
R
R
---
C
S
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
-----------
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
---
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
-----------
95
Blastp_CBE
83.38
66%
-109
- C1 -
-
5QIL
7.3
-
TGFR1_HUMAN
A:
[4-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
D
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
----
K
W
R
G
--
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
----
T
V
T
V
E
G
M
I
-
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
----
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
-
I
A
R
R
---
C
S
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
-----------
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
---
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
-----------
98
Blastp_CBE
83.35
66%
-110
- C1 -
-
5E8W
9.0
-
TGFR1_HUMAN
A:
[4-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
D
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
----
K
W
R
G
--
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
----
T
V
T
V
E
G
M
I
-
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
----
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
-
I
A
R
R
---
C
S
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
-----------
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
---
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
-----------
103
Blastp_CBE
83.28
66%
-115
- C1 -
-
4X2G
3.9
-
TGFR1_HUMAN
A:
[2-297]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
----
K
W
R
G
--
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
----
T
V
T
V
E
G
M
I
-
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
----
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
-
I
A
R
R
---
C
S
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
-----------
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
---
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
-----------
110
Blastp_CBE
83.22
66%
-115
- C1 -
-
1RW8
7.3
-
TGFR1_HUMAN
A:
[1-296]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
----
K
W
R
G
--
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
----
T
V
T
V
E
G
M
I
-
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
----
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
-
I
A
R
R
---
C
S
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
-----------
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
---
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
-----------
104
Blastp_CBE
83.20
66%
-116
- C1 -
-
4X2F
4.4
-
TGFR1_HUMAN
A:
[2-297]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
----
K
W
R
G
--
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
----
T
V
T
V
E
G
M
I
-
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
----
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
-
I
A
R
R
---
C
S
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
-----------
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
---
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
-----------
92
Blastp_CBE
83.07
64%
-106
- C1 -
-
3MDY
8.6
-
BMR1B_HUMAN
A:
[10-334]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
R
D
L
I
E
Q
S
Q
S
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
K
Q
I
Q
M
V
K
Q
I
G
K
G
R
Y
G
E
V
W
M
G
----
K
W
R
G
--
E
K
V
A
V
K
V
F
F
T
T
E
E
A
S
-----
W
F
R
E
T
E
I
Y
Q
T
V
L
M
R
H
E
N
I
L
G
F
--
I
A
A
D
-
I
K
G
T
G
S
W
T
Q
L
Y
L
I
T
D
Y
H
E
N
G
S
L
Y
D
Y
L
K
S
T
----
T
L
D
A
K
S
M
L
-
K
L
A
Y
S
S
V
S
G
L
C
H
L
H
T
E
I
-
F
-
S
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
K
F
I
-------------
P
N
T
R
V
G
T
K
R
Y
M
P
P
E
V
L
D
E
S
L
N
R
N
H
F
Q
S
Y
I
M
A
D
M
Y
S
F
G
L
I
L
W
E
-
V
A
R
R
---
C
V
S
G
G
I
V
E
E
Y
Q
L
P
Y
H
D
L
V
-----------
P
-----------
S
D
P
S
Y
E
D
M
R
E
I
V
C
I
K
K
L
R
P
---
S
F
P
N
R
W
S
S
D
E
-
C
L
R
Q
M
G
K
L
M
T
E
C
W
A
H
N
P
A
S
R
L
T
A
L
R
V
K
K
T
L
A
K
M
S
E
S
Q
D
------
99
Blastp_CBE
82.94
66%
-107
- C1 -
-
5E8T
2.5
-
TGFR1_HUMAN
A:
[4-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
D
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
----
K
W
R
G
--
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
----
T
V
T
V
E
G
M
I
-
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
----
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
-
I
A
R
R
---
C
S
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
-----------
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
---
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
-----------
102
Blastp_CBE
82.72
66%
-114
- C1 -
-
4X2J
5.6
-
TGFR1_HUMAN
A:
[2-297]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
----
K
W
R
G
--
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
----
T
V
T
V
E
G
M
I
-
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
----
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
-
I
A
R
R
---
C
S
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
-----------
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
---
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
-----------
101
Blastp_CBE
82.72
66%
-114
- C1 -
-
4X2K
5.6
-
TGFR1_HUMAN
A:
[2-297]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
----
K
W
R
G
--
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
----
T
V
T
V
E
G
M
I
-
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
----
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
-
I
A
R
R
---
C
S
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
-----------
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
---
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
-----------
96
Blastp_CBE
82.66
66%
-109
- C1 -
-
5QIK
8.0
-
TGFR1_HUMAN
A:
[4-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
D
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
----
K
W
R
G
--
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
----
T
V
T
V
E
G
M
I
-
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
----
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
-
I
A
R
R
---
C
S
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
-----------
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
---
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
-----------
115
Blastp_CBE
82.60
65%
-108
- C1 -
-
5E90
7.1
-
TGFR1_HUMAN
A:
[4-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
D
I
V
L
Q
E
S
V
G
K
G
R
F
G
E
V
W
R
G
----
K
W
R
G
--
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
F
Q
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
T
D
F
H
E
H
G
N
L
F
D
Y
L
N
R
Y
----
T
V
T
V
E
G
M
I
-
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
C
D
F
G
L
A
V
R
H
D
S
A
T
----
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
-
I
A
R
R
---
C
S
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
-----------
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
---
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
-----------
91
Blastp_CBE
82.60
64%
-106
- C1 -
-
3MDY
8.6
-
BMR1B_HUMAN
C:
[10-334]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
R
D
L
I
E
Q
S
Q
S
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
K
Q
I
Q
M
V
K
Q
I
G
K
G
R
Y
G
E
V
W
M
G
----
K
W
R
G
--
E
K
V
A
V
K
V
F
F
T
T
E
E
A
S
-----
W
F
R
E
T
E
I
Y
Q
T
V
L
M
R
H
E
N
I
L
G
F
--
I
A
A
D
-
I
K
G
T
G
S
W
T
Q
L
Y
L
I
T
D
Y
H
E
N
G
S
L
Y
D
Y
L
K
S
T
----
T
L
D
A
K
S
M
L
-
K
L
A
Y
S
S
V
S
G
L
C
H
L
H
T
E
I
-
F
-
S
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
K
F
I
-----------
I
P
P
N
T
R
V
G
T
K
R
Y
M
P
P
E
V
L
D
E
S
L
N
R
N
H
F
Q
S
Y
I
M
A
D
M
Y
S
F
G
L
I
L
W
E
-
V
A
R
R
---
C
V
S
G
G
I
V
E
E
Y
Q
L
P
Y
H
D
L
V
-----------
P
-----------
S
D
P
S
Y
E
D
M
R
E
I
V
C
I
K
K
L
R
P
---
S
F
P
N
R
W
S
S
D
E
-
C
L
R
Q
M
G
K
L
M
T
E
C
W
A
H
N
P
A
S
R
L
T
A
L
R
V
K
K
T
L
A
K
M
S
E
S
Q
D
------
164
HHSearch
82.57
65%
-109
- C1 -
-
4X2J
5.6
-
TGFR1_HUMAN
A:
[4-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
----
K
W
R
G
--
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
----
T
V
T
V
E
G
M
I
-
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
----
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
-
I
A
R
R
---
C
S
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
-----------
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
---
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
-------
113
Blastp_CBE
81.56
66%
-112
- C1 -
-
3GXL
8.1
-
TGFR1_HUMAN
A:
[1-295]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
----
K
W
-----
E
V
A
V
K
I
F
S
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
----
T
V
T
V
E
G
M
I
-
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
----
D
T
I
D
-----
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
-
I
A
R
R
---
C
S
---
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
-----------
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
---
N
I
P
N
R
--
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
-----------
66
Blastp_CBE
80.66
66%
-107
- C1 -
-
1PY5
6.2
-
TGFR1_HUMAN
A:
[26-321]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
----
K
W
R
G
--
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
-----
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
--
I
A
A
D
-
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
----
T
V
T
V
E
G
M
I
-
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-
V
-
G
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
----
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
-
I
A
R
R
---
C
S
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
-----------
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
---
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
-----------
169
HHSearch
79.52
64%
-106
- C1 -
-
3MDY
8.6
-
BMR1B_HUMAN
A:
[30-333]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
Q
R
T
I
A
K
Q
I
Q
M
V
K
Q
I
G
K
G
R
Y
G
E
V
W
M
G
----
K
W
R
G
--
E
K
V
A
V
K
V
F
F
T
T
E
E
A
S
-----
W
F
R
E
T
E
I
Y
Q
T
V
L
M
R
H
E
N
I
L
G
F
--
I
A
A
D
-
I
K
G
T
G
S
W
T
Q
L
Y
L
I
T
D
Y
H
E
N
G
S
L
Y
D
Y
L
K
S
T
----
T
L
D
A
K
S
M
L
-
K
L
A
Y
S
S
V
S
G
L
C
H
L
H
T
E
I
-
F
-
S
--
T
Q
G
---
K
P
A
--
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
K
F
I
-------------
P
N
T
R
V
G
T
K
R
Y
M
P
P
E
V
L
D
E
S
L
N
R
N
H
F
Q
S
Y
I
M
A
D
M
Y
S
F
G
L
I
L
W
E
-
V
A
R
R
---
C
V
S
G
G
I
V
E
E
Y
Q
L
P
Y
H
D
L
V
-----------
P
-----------
S
D
P
S
Y
E
D
M
R
E
I
V
C
I
K
K
L
R
P
---
S
F
P
N
R
W
S
S
D
E
-
C
L
R
Q
M
G
K
L
M
T
E
C
W
A
H
N
P
A
S
R
L
T
A
L
R
V
K
K
T
L
A
K
M
S
E
S
Q
-------
124
Blastp_CBE
65.04
38%
-40
- C1 -
-
2QLU
3.0
-
AVR2B_HUMAN
A:
[17-311]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
L
L
E
I
K
A
R
G
R
F
G
C
V
W
K
A
----
Q
L
M
N
--
D
F
V
A
V
K
I
F
P
L
Q
D
K
Q
S
-----
W
Q
S
E
R
E
I
F
S
T
P
G
M
K
H
E
N
L
L
Q
F
--
I
A
A
E
-
K
R
G
S
N
L
E
V
E
L
W
L
I
T
A
F
H
D
K
G
S
L
T
D
Y
L
K
G
N
----
I
I
T
W
N
E
L
C
-
H
V
A
E
T
M
S
R
G
L
S
Y
L
H
E
D
V
-
P
-
W
--
C
R
G
EGH
K
P
S
--
I
A
H
R
D
F
K
S
K
N
V
L
L
K
S
D
L
T
A
V
L
A
D
F
G
L
A
V
R
F
E
P
G
K
----
P
P
G
D
--
T
H
G
Q
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
F
Q
-
R
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
V
S
R
C
---
K
A
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
-----------
G
-----------
Q
H
P
S
L
E
E
L
Q
E
V
V
V
H
K
K
M
R
P
---
T
I
K
D
H
W
L
K
H
P
-
G
L
A
Q
L
C
V
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
E
E
R
V
S
L
I
R
R
S
--------
118
Blastp_CBE
64.42
40%
-37
- C1 -
-
4ASX
5.4
-
AVR2A_HUMAN
B:
[26-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
----
Q
L
L
N
--
E
Y
V
A
V
K
I
F
P
I
Q
D
K
Q
S
-----
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
--
I
G
A
E
-
K
R
G
T
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
A
N
----
V
V
S
W
N
E
L
C
-
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
-
P
-
G
--
L
K
D
GH-
K
P
A
--
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
E
A
G
K
----
S
A
G
D
T
--
H
G
Q
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
F
Q
-
R
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
-
L
A
S
R
C--
T
A
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
-----------
G
-----------
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
---
V
L
R
D
Y
W
Q
K
H
A
-
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
-----------
120
Blastp_CBE
64.39
40%
-40
- C1 -
-
3SOC
7.1
-
AVR2A_HUMAN
B:
[26-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
----
Q
L
L
N
--
E
Y
V
A
V
K
I
F
P
I
Q
D
K
Q
S
-----
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
--
I
G
A
E
-
K
R
G
T
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
A
N
----
V
V
S
W
N
E
L
C
-
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
-
P
-
G
--
L
K
D
GH-
K
P
A
--
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
E
A
G
K
----
S
A
--
T
--
H
G
Q
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
F
Q
-
R
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
-
L
A
S
R
C--
T
A
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
-----------
G
-----------
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
---
V
L
R
D
Y
W
Q
K
H
A
-
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
-----------
123
Blastp_CBE
64.33
40%
-36
- C1 -
-
3Q4T
7.7
-
AVR2A_HUMAN
A:
[26-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
----
Q
L
L
N
--
E
Y
V
A
V
K
I
F
P
I
Q
D
K
Q
S
-----
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
--
I
G
A
E
-
K
R
G
T
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
A
N
----
V
V
S
W
N
E
L
C
-
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
-
P
-
G
--
L
K
D
GH-
K
P
A
--
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
E
A
G
K
----
S
A
G
D
T
--
H
G
Q
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
F
Q
-
R
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
-
L
A
S
R
C--
T
A
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
-----------
G
-----------
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
---
V
L
R
D
Y
W
Q
K
H
A
-
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
-----------
119
Blastp_CBE
64.06
40%
-37
- C1 -
-
4ASX
5.4
-
AVR2A_HUMAN
A:
[26-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
----
Q
L
L
N
--
E
Y
V
A
V
K
I
F
P
I
Q
D
K
Q
S
-----
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
--
I
G
A
E
-
K
R
G
T
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
A
N
----
V
V
S
W
N
E
L
C
-
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
-
P
-
G
--
L
K
D
GH-
K
P
A
--
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
E
A
G
K
----
S
A
G
-
T
--
H
G
Q
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
F
Q
-
R
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
-
L
A
S
R
C--
T
A
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
-----------
G
-----------
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
---
V
L
R
D
Y
W
Q
K
H
A
-
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
-----------
174
HHSearch
63.99
37%
-17
- C1 -
-
5E8Y
8.6
-
TGFR2_HUMAN
A:
[9-308]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
I
E
L
D
T
L
V
G
K
G
R
F
A
E
V
Y
K
A
----
K
L
K
Q
QF
E
T
V
A
V
K
I
F
P
Y
E
E
Y
A
S
-----
W
K
T
E
K
D
I
F
S
D
I
N
L
K
H
E
N
I
L
Q
F
--
L
T
A
E
-
E
R
K
T
E
L
G
K
Q
Y
W
L
I
T
A
F
H
A
K
G
N
L
Q
E
Y
L
T
R
H
----
V
I
S
W
E
D
L
R
-
K
L
G
S
S
L
A
R
G
I
A
H
L
H
S
D
H
-
T
P
C
--
G
R
P
---
K
M
P
--
I
V
H
R
D
L
K
S
S
N
I
L
V
K
N
D
L
T
C
C
L
C
D
F
G
L
S
L
R
L
D
P
T
L
----
S
V
D
D
L
A
N
S
G
Q
V
G
T
A
R
Y
M
A
P
E
V
L
A
S
A
M
N
L
E
N
V
E
S
F
K
Q
T
D
V
Y
S
M
A
L
V
L
W
E
-
M
T
S
R
---
C
N
A
V
G
E
V
K
D
Y
E
P
P
F
G
S
K
V
-----------
R
-----------
E
H
P
C
V
A
S
M
A
D
N
V
L
A
D
A
G
R
P
---
E
I
P
S
F
W
L
N
H
Q
-
G
I
Q
M
V
C
E
T
L
T
E
C
W
D
H
D
P
E
A
R
L
T
A
Q
C
V
A
E
R
F
S
E
L
-----------
122
Blastp_CBE
63.12
40%
-36
- C1 -
-
3Q4T
7.3
-
AVR2A_HUMAN
B:
[26-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
----
Q
L
L
N
--
E
Y
V
A
V
K
I
F
P
I
Q
D
K
Q
S
-----
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
--
I
G
A
E
-
K
R
G
T
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
A
N
----
V
V
S
W
N
E
L
C
-
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
-
P
-
G
--
L
K
D
GH-
K
P
A
--
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
E
A
G
K
----
S
A
--
T
--
H
G
Q
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
F
Q
-
R
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
-
L
A
S
R
C--
T
A
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
-----------
G
-----------
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
---
V
L
R
D
Y
W
Q
K
H
A
-
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
-----------
175
HHSearch
62.88
37%
-13
- C1 -
-
5QIN
7.8
-
TGFR2_HUMAN
A:
[9-308]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
I
E
L
D
T
L
V
G
K
G
R
F
A
E
V
Y
K
A
----
K
L
K
-QF
E
T
V
A
V
K
I
F
P
Y
E
E
Y
A
S
-----
W
K
T
E
K
D
I
F
S
D
I
N
L
K
H
E
N
I
L
Q
F
--
L
T
A
E
-
E
R
K
T
E
L
G
K
Q
Y
W
L
I
T
A
F
H
A
K
G
N
L
Q
E
Y
L
T
R
H
----
V
I
S
W
E
D
L
R
-
K
L
G
S
S
L
A
R
G
I
A
H
L
H
S
D
H
-
T
-
P
C-
G
R
P
---
K
M
P
--
I
V
H
R
D
L
K
S
S
N
I
L
V
K
N
D
L
T
C
C
L
C
D
F
G
L
S
L
R
L
D
P
T
L
----
S
V
D
D
L
A
N
--
Q
V
G
T
A
R
Y
M
A
P
E
V
L
A
S
A
M
N
L
E
N
V
E
S
F
K
Q
T
D
V
Y
S
M
A
L
V
L
W
E
-
M
T
S
R
---
C
N
A
V
G
E
V
K
D
Y
E
P
P
F
G
S
K
V
-----------
R
-----------
E
H
P
C
V
A
S
M
A
D
N
V
L
A
D
A
G
R
P
---
E
I
P
S
F
W
L
N
H
Q
-
G
I
Q
M
V
C
E
T
L
T
E
C
W
D
H
D
P
E
A
R
L
T
A
Q
C
V
A
E
R
F
S
E
L
-----------
121
Blastp_CBE
62.60
40%
-33
- C1 -
-
3SOC
7.2
-
AVR2A_HUMAN
A:
[26-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
----
Q
L
L
N
--
E
Y
V
A
V
K
I
F
P
I
Q
D
K
Q
S
-----
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
--
I
G
A
E
-
K
R
G
T
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
A
N
----
V
V
S
W
N
E
L
C
-
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
-
P
-
G
--
L
K
D
GH-
K
P
A
--
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
E
A
G
K
----
S
A
G
D
T
--
H
G
Q
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
F
Q
-
R
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
-
L
A
S
R
C--
T
A
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
-----------
G
-----------
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
---
V
L
R
D
Y
W
Q
K
H
A
-
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
-----------
179
HHSearch
62.27
40%
-42
- C1 -
-
4ASX
5.4
-
AVR2A_HUMAN
A:
[24-319]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
P
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
----
Q
L
L
N
--
E
Y
V
A
V
K
I
F
P
I
Q
D
K
Q
S
-----
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
--
I
G
A
E
-
K
R
G
T
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
A
N
----
V
V
S
W
N
E
L
C
-
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
-
P
-
G
LK
D
G
H
---
K
P
A
--
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
E
A
G
K
----
S
A
--
G
-
T
H
G
Q
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
F
Q
-
R
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
-
L
A
S
R
-------------
C
T
A
A
D
G
P
V
DEYMLPFEEEI
G
-----------
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
---
V
L
R
D
Y
W
Q
K
H
A
-
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
L
--------
128
Blastp_CBE
62.27
38%
-9
- C1 -
-
5E8Y
8.6
-
TGFR2_HUMAN
A:
[11-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
L
D
T
L
V
G
K
G
R
F
A
E
V
Y
K
A
KLKQ--
Q
F
--
E
T
V
A
V
K
I
F
P
Y
E
E
Y
A
S
-----
W
K
T
E
K
D
I
F
S
D
I
N
L
K
H
E
N
I
L
Q
F
--
L
T
A
E
-
E
R
K
T
E
L
G
K
Q
Y
W
L
I
T
A
F
H
A
K
G
N
L
Q
E
Y
L
T
R
H
----
V
I
S
W
E
D
L
R
-
K
L
G
S
S
L
A
R
G
I
A
H
L
H
S
D
--
H
-
T
--
P
C
G
---
R
P
K
MP
I
V
H
R
D
L
K
S
S
N
I
L
V
K
N
D
L
T
C
C
L
C
D
F
G
L
S
L
R
L
D
P
T
L
----
S
V
D
D
L
A
N
S
G
Q
V
G
T
A
R
Y
M
A
P
E
V
L
A
S
A
M
N
L
E
N
V
E
S
F
K
Q
T
D
V
Y
S
M
A
L
V
L
W
E
-
M
T
S
R
---
C
N
A
V
G
E
V
K
D
Y
E
P
P
F
G
S
K
V
-----------
R
-----------
E
H
P
C
V
A
S
M
A
D
N
V
L
A
D
A
G
R
P
---
E
I
P
S
F
W
L
N
H
Q
-
G
I
Q
M
V
C
E
T
L
T
E
C
W
D
H
D
P
E
A
R
L
T
A
Q
C
V
A
E
R
F
S
E
L
-----------
125
Blastp_CBE
62.17
38%
-15
- C1 -
-
5QIN
7.8
-
TGFR2_HUMAN
A:
[11-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
L
D
T
L
V
G
K
G
R
F
A
E
V
Y
K
A
KLK---
Q
F
--
E
T
V
A
V
K
I
F
P
Y
E
E
Y
A
S
-----
W
K
T
E
K
D
I
F
S
D
I
N
L
K
H
E
N
I
L
Q
F
--
L
T
A
E
-
E
R
K
T
E
L
G
K
Q
Y
W
L
I
T
A
F
H
A
K
G
N
L
Q
E
Y
L
T
R
H
----
V
I
S
W
E
D
L
R
-
K
L
G
S
S
L
A
R
G
I
A
H
L
H
S
D
--
H
-
T
--
P
C
G
---
R
P
K
MP
I
V
H
R
D
L
K
S
S
N
I
L
V
K
N
D
L
T
C
C
L
C
D
F
G
L
S
L
R
L
D
P
T
L
----
S
V
D
D
L
A
N
--
Q
V
G
T
A
R
Y
M
A
P
E
V
L
A
S
A
M
N
L
E
N
V
E
S
F
K
Q
T
D
V
Y
S
M
A
L
V
L
W
E
-
M
T
S
R
---
C
N
A
V
G
E
V
K
D
Y
E
P
P
F
G
S
K
V
-----------
R
-----------
E
H
P
C
V
A
S
M
A
D
N
V
L
A
D
A
G
R
P
---
E
I
P
S
F
W
L
N
H
Q
-
G
I
Q
M
V
C
E
T
L
T
E
C
W
D
H
D
P
E
A
R
L
T
A
Q
C
V
A
E
R
F
S
E
L
-----------
127
Blastp_CBE
61.89
38%
-9
- C1 -
-
5E91
6.5
-
TGFR2_HUMAN
A:
[11-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
L
D
T
L
V
G
K
G
R
F
A
E
V
Y
K
A
KLK-------
E
T
V
A
V
K
I
F
P
Y
E
E
Y
A
S
-----
W
K
T
E
K
D
I
F
S
D
I
N
L
K
H
E
N
I
L
Q
F
--
L
T
A
E
-
E
R
K
T
E
L
G
K
Q
Y
W
L
I
T
A
F
H
A
K
G
N
L
Q
E
Y
L
T
R
H
----
V
I
S
W
E
D
L
R
-
K
L
G
S
S
L
A
R
G
I
A
H
L
H
S
D
--
H
-
T
--
P
C
G
---
R
P
K
MP
I
V
H
R
D
L
K
S
S
N
I
L
V
K
N
D
L
T
C
C
L
C
D
F
G
L
S
L
R
L
D
P
T
L
----
S
V
D
D
L
A
N
S
G
Q
V
G
T
A
R
Y
M
A
P
E
V
L
A
S
A
M
N
L
E
N
V
E
S
F
K
Q
T
D
V
Y
S
M
A
L
V
L
W
E
-
M
T
S
R
---
C
N
A
V
G
E
V
K
D
Y
E
P
P
F
G
S
K
V
-----------
R
-----------
E
H
P
C
V
A
S
M
A
D
N
V
L
A
D
A
G
R
P
---
E
I
P
S
F
W
L
N
H
Q
-
G
I
Q
M
V
C
E
T
L
T
E
C
W
D
H
D
P
E
A
R
L
T
A
Q
C
V
A
E
R
F
S
E
L
E
H
---------
181
HHSearch
61.67
40%
-40
- C1 -
-
3SOC
7.2
-
AVR2A_HUMAN
A:
[24-319]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
P
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
----
Q
L
L
N
--
E
Y
V
A
V
K
I
F
P
I
Q
D
K
Q
S
-----
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
--
I
G
A
E
-
K
R
G
T
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
A
N
----
V
V
S
W
N
E
L
C
-
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
-
P
-
G
LK
D
G
H
---
K
P
A
--
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
E
A
G
K
----
S
A
--
G
D
T
H
G
Q
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
F
Q
-
R
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
-
L
A
S
R
---
C
----------
T
A
A
D
G
P
V
-----------
D
EYMLPFEEEIG
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
---
V
L
R
D
Y
W
Q
K
H
A
-
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
L
--------
126
Blastp_CBE
61.57
38%
-8
- C1 -
-
5E92
7.7
-
TGFR2_HUMAN
A:
[11-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
L
D
T
L
V
G
K
G
R
F
A
E
V
Y
K
A
KLK----
F
--
E
T
V
A
V
K
I
F
P
Y
E
E
Y
A
S
-----
W
K
T
E
K
D
I
F
S
D
I
N
L
K
H
E
N
I
L
Q
F
--
L
T
A
E
-
E
R
K
T
E
L
G
K
Q
Y
W
L
I
T
A
F
H
A
K
G
N
L
Q
E
Y
L
T
R
H
----
V
I
S
W
E
D
L
R
-
K
L
G
S
S
L
A
R
G
I
A
H
L
H
S
D
--
H
-
T
--
P
C
G
---
R
P
K
MP
I
V
H
R
D
L
K
S
S
N
I
L
V
K
N
D
L
T
C
C
L
C
D
F
G
L
S
L
R
L
D
P
T
L
----
S
V
D
D
L
A
N
S
G
Q
V
G
T
A
R
Y
M
A
P
E
V
L
A
S
A
M
N
L
E
N
V
E
S
F
K
Q
T
D
V
Y
S
M
A
L
V
L
W
E
-
M
T
S
R
---
C
N
A
V
G
E
V
K
D
Y
E
P
P
F
G
S
K
V
-----------
R
-----------
E
H
P
C
V
A
S
M
A
D
N
V
L
A
D
A
G
R
P
---
E
I
P
S
F
W
L
N
H
Q
-
G
I
Q
M
V
C
E
T
L
T
E
C
W
D
H
D
P
E
A
R
L
T
A
Q
C
V
A
E
R
F
S
E
L
E
H
---------
131
Blastp_CBE
52.54
38%
-28
- C1 -
-
3G2F
6.3
-
BMPR2_HUMAN
A:
[15-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
L
L
E
L
I
G
R
G
R
Y
G
A
V
Y
K
G
----
S
L
D
E
--
R
P
V
A
V
K
V
F
S
F
A
N
R
Q
N
-----
F
I
N
E
K
N
I
Y
R
V
P
L
M
E
H
D
N
I
A
R
F
--
I
V
G
D
E
R
V
T
A
D
G
R
M
E
Y
L
L
V
M
E
Y
Y
P
N
G
S
L
C
K
Y
L
S
L
H
----
T
S
D
W
V
S
S
C
-
R
L
A
H
S
V
T
R
G
L
A
Y
L
H
T
E
L
P
R
-
G
--
D
H
Y
---
K
P
A
--
I
S
H
R
D
L
N
S
R
N
V
L
V
K
N
D
G
T
C
V
I
S
D
F
G
L
S
M
R
L
T
G
N
R
LVRP---------
E
V
G
T
I
R
Y
M
A
P
E
V
L
E
G
A
V
N
L
R
D
E
S
A
L
K
Q
V
D
M
Y
A
L
G
L
I
Y
W
E
-
I
F
M
R
CTD
L
F
P
G
E
S
V
P
E
Y
Q
M
A
F
Q
T
E
V
-----------
G
-----------
N
H
P
T
F
E
D
M
Q
V
L
V
S
R
E
K
Q
R
P
---
K
F
P
E
A
W
K
E
N
S
L
A
V
R
S
L
K
E
T
I
E
D
C
W
D
Q
D
A
E
A
R
L
T
A
---------------------
130
Blastp_CBE
52.17
38%
-28
- C1 -
-
3G2F
6.0
-
BMPR2_HUMAN
B:
[15-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
L
L
E
L
I
G
R
G
R
Y
G
A
V
Y
K
G
----
S
L
D
E
--
R
P
V
A
V
K
V
F
S
F
A
N
R
Q
N
-----
F
I
N
E
K
N
I
Y
R
V
P
L
M
E
H
D
N
I
A
R
F
--
I
V
G
D
E
R
V
T
A
D
G
R
M
E
Y
L
L
V
M
E
Y
Y
P
N
G
S
L
C
K
Y
L
S
L
H
----
T
S
D
W
V
S
S
C
-
R
L
A
H
S
V
T
R
G
L
A
Y
L
H
T
E
L
P
R
-
G
--
D
H
Y
---
K
P
A
--
I
S
H
R
D
L
N
S
R
N
V
L
V
K
N
D
G
T
C
V
I
S
D
F
G
L
S
M
R
L
T
G
N
R
L-------------
V
G
T
I
R
Y
M
A
P
E
V
L
E
G
A
V
N
L
R
D
E
S
A
L
K
Q
V
D
M
Y
A
L
G
L
I
Y
W
E
-
I
F
M
R
CTD
L
F
P
G
E
S
V
P
E
Y
Q
M
A
F
Q
T
E
V
-----------
G
-----------
N
H
P
T
F
E
D
M
Q
V
L
V
S
R
E
K
Q
R
P
---
K
F
P
E
A
W
K
E
N
S
L
A
V
R
S
L
K
E
T
I
E
D
C
W
D
Q
D
A
E
A
R
L
T
A
---------------------
146
Blastp_CBE
42.63
31%
-28
- C1 -
-
6OKO
9.0
-
RIPK3_MOUSE
A:
[14-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
-
L
V
S
R
---
E
E
L
K
K
L
E
F
V
G
K
G
G
F
G
V
V
F
R
A
HHR-
T
W
-
N
--
H
D
V
A
V
K
I
V
N
S
K
-
K
I
S
-----
W
----
E
V
K
A
M
V
N
L
R
N
E
N
V
L
L
L
LG
V
T
E
D
-
L
Q
W
D
F
V
S
G
Q
A
-
L
V
T
R
F
M
E
N
G
S
L
A
G
L
L
Q
P
E
----
A
P
R
P
W
P
L
L
C
R
L
L
Q
E
V
V
L
G
M
C
Y
L
H
----------
S
L
---
D
P
P
--
L
L
H
R
D
L
K
P
S
N
I
L
L
D
P
E
L
H
A
K
L
A
D
F
-------------------------
G
T
L
A
Y
L
D
P
E
L
L
---
F
K
V
N
-
L
K
A
S
K
A
S
D
V
Y
S
F
G
I
L
V
W
A
-
V
L
A
G
---
R
E
A
E
L
V
-----------------------------------
D
--------------
Q
S
R
P
PLT
E
L
P
P
G
S
P
E
T
P
-
G
L
E
K
L
K
E
L
M
I
H
C
W
-------------------------------
145
Blastp_CBE
40.74
31%
-28
- C1 -
-
6OKO
8.1
-
RIPK3_MOUSE
B:
[13-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
P
-
L
V
S
R
---
E
E
L
K
K
L
E
F
V
G
K
G
G
F
G
V
V
F
R
A
HHR-
T
W
-
N
--
H
D
V
A
V
K
I
V
N
S
K
-
K
I
S
-----
W
----
E
V
K
A
M
V
N
L
R
N
E
N
V
L
L
L
LG
V
T
E
D
-
L
Q
W
D
F
V
S
G
Q
A
-
L
V
T
R
F
M
E
N
G
S
L
A
G
L
L
Q
P
E
----
A
P
R
P
W
P
L
L
C
R
L
L
Q
E
V
V
L
G
M
C
Y
L
H
----------
S
L
---
D
P
P
--
L
L
H
R
D
L
K
P
S
N
I
L
L
D
P
E
L
H
A
K
L
A
D
F
---------------------------
L
A
Y
L
D
P
E
L
L
---
F
K
V
N
-
L
K
A
S
K
A
S
D
V
Y
S
F
G
I
L
V
W
A
-
V
L
A
G
---
R
E
A
E
L
--------------------------------------------------
R
Q
S
R
P
PLT
E
L
P
P
G
S
P
E
T
P
-
G
L
E
K
L
K
E
L
M
I
H
C
W
-------------------------------
132
Blastp_CBE
34.03
32%
-28
- C1 -
-
3PPZ
8.0
-
CTR1_ARATH
A:
[39-233]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
I
K
E
K
I
G
A
G
S
F
G
T
V
H
R
A
----
E
W
H
G
--
S
D
V
A
V
K
I
L
M
E
----
A
ERVNE
F
L
R
E
V
A
I
M
K
R
--
L
R
H
P
N
I
V
L
F
-------
M
G
A
V
T
Q
P
P
N
L
S
I
V
T
E
Y
L
S
R
G
S
L
Y
R
L
L
H
K
S
GARE
Q
L
D
E
R
R
R
L
-
S
M
A
Y
D
V
A
K
G
M
N
Y
L
H
----------
N
R
---
N
P
P
--
I
V
H
R
D
L
K
S
P
N
L
L
V
D
K
K
Y
T
V
K
V
C
D
F
G
L
S
R
L
K
A
S
F
L
----
S
K
A
K
------
A
G
T
P
E
W
M
A
P
E
V
L
R
D
E
------
P
S
N
E
K
S
D
V
Y
S
F
G
V
I
L
W
E
-
L
A
---------------------------------------------------------------------------------------------------------------------------