@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Screening
Virtual Screening Score
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : AKT1_HUMAN: (2020-09-04 )
MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
Atome Classification :
(444 SA)
.........10........20........30........40........50........60........70........80........90....----....100.......110.......120.......130.......140.......150.......-160.......---170--.-.----......180.....--..190.......200-.---.-.---.-...210.......220.......230.......240-........250.......260.......270.......280.-......290.......300.--....--.-.-310........320..---.-----....330.......340...-....-----350-.---.----..---.---....360-.--....--...-----370.......380.......390......-...-400........410---.......420....--.-----..430.......-440.......450.......460......---.470.......480
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(pKd)
(pKd)
(Uniprot)
MS
D
V
A
I
V
K
EG
W
L
H
KRG
E
Y
I
KTWR
P
R
Y
F
L
L
KND
G
T
F
IGYKERPQDV
D
Q
REAPLNNFSV
A
Q
C
Q
L
MKTERPRP
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
TFHVET
P
E
E
----
R
E
E
W
T
T
A
I
Q
T
V
A
D
G
L
K
K
Q
E
E
E
EMDFRSGSPSDNSG
A
E
E
M
E
VSLAKPKH
R
V
T
M
N
E
F
E
Y
L
K
L
LGKG-TFG
K
V
I
L
V
K
E---KA---T-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
IV--
A
K
D
E
V
A
H
T
L
TENRVL-Q---N-S---R-H
P
F
L
T
A
L
K
YSFQTH
D
R
L
C
F
V
M
E
YANG
G
E
L
F
F
H
L
S
R
--
E
RV
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
HSEKN
V
V
Y
R
D
L
K
L
E
N
L
M
LD-KDG
H
I
K
I
T
D
F
G
L
C
K
E
G
IKDG--A
T
M
K--T-F-C-G
T
P
E
Y
L
A
P
E
VLEDN---D-----YGR
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
CG-RLPF-----Y---N---Q----
D
H
---
E
---
K
L
F
E
L
I
--
L
--
M
E
EI--RFP-----RTLGP
E
A
K
S
L
L
S
G
L
L
KK
D
P
K
Q
--RLGGG
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
KKLSPPFK--P-----QVTSETDTRYF
D
-
E
E
FT
A
Q
M
I
T
ITPPDQDD
S
M
E
C
VDSERRPH---FPQFSYSASGTA
5
PsiBlast_PDB
93.96
99%
-99
- C2 -
-
6HHJ
-
-
AKT1_HUMAN
A:
[3-444]
--
D
V
A
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
K
T
W
R
P
R
Y
F
L
L
K
N
D
G
T
F
I
G
Y
K
E
R
P
Q
--
D
Q
R
E
A
P
L
N
N
F
S
V
A
Q
C
Q
L
M
K
T
E
R
P
R
P
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
T
F
H
V
E
T
P
E
E
----
R
E
E
W
T
T
A
I
Q
T
V
A
D
G
L
K
K
Q
------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
---
N
-
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
--
A
T
M
K
--
T
-
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
---
N
---
Q
----
D
H
---
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
E
F
T
A
---------------------------------------
551
HHSearch
92.93
99%
-101
- C2 -
-
6S9W
9.9
-
?
A:
[3-444]
--
D
V
A
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
K
T
W
R
P
R
Y
F
L
L
K
N
D
G
T
F
I
G
Y
K
E
R
P
Q
D
V
D
Q
R
E
A
P
L
N
N
F
S
V
A
Q
C
Q
L
M
K
T
E
R
P
R
P
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
T
F
H
V
E
T
P
E
E
----
R
E
E
W
T
T
A
I
Q
T
V
A
D
G
L
K
K
-----------------------------
K
H
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
---
N
-
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
----
A
T
M
K
--
T
-
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
---
N
---
Q
----
D
H
---
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
E
F
T
A
---------------------------------------
7
PsiBlast_PDB
92.93
99%
-101
- C2 -
-
6S9W
-
-
?
A:
[3-444]
--
D
V
A
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
K
T
W
R
P
R
Y
F
L
L
K
N
D
G
T
F
I
G
Y
K
E
R
P
Q
D
V
D
Q
R
E
A
P
L
N
N
F
S
V
A
Q
C
Q
L
M
K
T
E
R
P
R
P
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
T
F
H
V
E
T
P
E
E
----
R
E
E
W
T
T
A
I
Q
T
V
A
D
G
L
K
K
-----------------------------
K
H
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
---
N
-
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
----
A
T
M
K
--
T
-
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
---
N
---
Q
----
D
H
---
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
E
F
T
A
---------------------------------------
4
PsiBlast_PDB
90.71
99%
-97
- C2 -
-
6HHI
-
-
AKT1_HUMAN
A:
[3-444]
--
D
V
A
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
K
T
W
R
P
R
Y
F
L
L
K
N
D
G
T
F
I
G
Y
K
E
R
P
Q
D
---
R
E
A
P
L
N
N
F
S
V
A
Q
C
Q
L
M
K
T
E
R
P
R
P
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
T
F
H
V
E
T
P
E
E
----
R
E
E
W
T
T
A
I
Q
T
V
A
D
G
L
K
K
-------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-------------------
Q
---
N
-
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
-----
T
M
K
--
T
-
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
---
N
---
Q
----
D
H
---
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
E
F
T
A
---------------------------------------
2
PsiBlast_PDB
90.57
99%
-100
- C2 -
-
6HHG
-
-
AKT1_HUMAN
A:
[3-444]
--
D
V
A
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
K
T
W
R
P
R
Y
F
L
L
K
N
D
G
T
F
I
G
Y
K
E
R
P
Q
D
----
E
A
P
L
N
N
F
S
V
A
Q
C
Q
L
M
K
T
E
R
P
R
P
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
T
F
H
V
E
T
P
E
E
----
R
E
E
W
T
T
A
I
Q
T
V
A
D
G
L
K
K
-------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-------------------------
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
-----
T
M
K
--
T
-
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
---
N
---
Q
----
D
H
---
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
E
F
T
A
---------------------------------------
552
HHSearch
89.69
99%
-100
- C2 -
-
6S9X
11.6
-
?
A:
[3-443]
--
D
V
A
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
K
T
W
R
P
R
Y
F
L
L
K
N
D
G
T
F
I
G
Y
K
E
R
P
Q
D
----
E
A
P
L
N
N
F
S
V
A
Q
C
Q
L
M
K
T
E
R
P
R
P
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
T
F
H
V
E
T
P
E
E
----
R
E
E
W
T
T
A
I
Q
T
V
A
D
G
L
K
--------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-------------------
Q
---
N
-
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
------------
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
---
N
---
Q
----
D
H
---
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
E
F
T
----------------------------------------
8
PsiBlast_PDB
89.69
99%
-100
- C2 -
-
6S9X
-
-
?
A:
[3-443]
--
D
V
A
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
K
T
W
R
P
R
Y
F
L
L
K
N
D
G
T
F
I
G
Y
K
E
R
P
Q
D
----
E
A
P
L
N
N
F
S
V
A
Q
C
Q
L
M
K
T
E
R
P
R
P
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
T
F
H
V
E
T
P
E
E
----
R
E
E
W
T
T
A
I
Q
T
V
A
D
G
L
K
--------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-------------------
Q
---
N
-
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
------------
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
---
N
---
Q
----
D
H
---
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
E
F
T
----------------------------------------
6
PsiBlast_PDB
88.86
99%
-112
- C2 -
-
6HHF
-
-
AKT1_HUMAN
A:
[3-439]
--
D
V
A
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
K
T
W
R
P
R
Y
F
L
L
K
N
D
G
T
F
I
G
Y
K
E
R
P
--------
P
L
N
N
F
S
V
A
Q
C
Q
L
M
K
T
E
R
P
R
P
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
T
F
H
V
E
T
P
E
E
----
R
E
E
W
T
T
A
I
Q
T
V
A
D
G
L
K
K
Q
-------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-------------------------
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
---------------------
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
---
N
---
Q
----
D
H
---
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
---------------------------------------------
3
PsiBlast_PDB
88.25
99%
-98
- C2 -
-
6HHH
-
-
AKT1_HUMAN
A:
[2-439]
-
S
D
V
A
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
K
T
W
R
P
R
Y
F
L
L
K
N
D
G
T
F
I
G
Y
K
E
R
P
Q
D
V
---
E
A
P
L
N
N
F
S
V
A
Q
C
Q
L
M
K
T
E
R
P
R
P
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
T
F
H
V
E
T
P
E
E
----
R
E
E
W
T
T
A
I
Q
T
V
A
D
G
L
K
K
-------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
----------------
R
V
L
-
Q
---
N
-
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
------------------
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
---
N
---
Q
----
D
H
---
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
---------------------------------------------
550
HHSearch
88.01
99%
-104
- C2 -
-
4EJN
11.8
-
AKT1_HUMAN
A:
[4-438]
---
V
A
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
K
T
W
R
P
R
Y
F
L
L
K
N
D
G
T
F
I
G
Y
K
E
R
P
-------
A
P
L
N
N
F
S
V
A
Q
C
Q
L
M
K
T
E
R
P
R
P
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
T
F
H
V
E
T
P
E
E
----
R
E
E
W
T
T
A
I
Q
T
V
A
D
G
----------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
---------------
V
L
-
Q
---
N
-
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
-------
K
--
T
-
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
---
N
---
Q
----
D
H
---
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
----------------------------------------------
1
PsiBlast_PDB
88.01
99%
-104
- C2 -
-
4EJN
-
-
AKT1_HUMAN
A:
[4-438]
---
V
A
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
K
T
W
R
P
R
Y
F
L
L
K
N
D
G
T
F
I
G
Y
K
E
R
P
-------
A
P
L
N
N
F
S
V
A
Q
C
Q
L
M
K
T
E
R
P
R
P
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
T
F
H
V
E
T
P
E
E
----
R
E
E
W
T
T
A
I
Q
T
V
A
D
G
----------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
---------------
V
L
-
Q
---
N
-
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
-------
K
--
T
-
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
---
N
---
Q
----
D
H
---
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
----------------------------------------------
9
PsiBlast_PDB
86.62
100%
-113
- C2 -
-
3O96
-
-
AKT1_HUMAN
A:
[5-432]
-
S
D
V
A
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
K
T
W
R
P
R
Y
F
L
L
K
N
D
G
T
F
I
G
Y
K
E
R
P
Q
D
V
---
E
A
P
L
N
N
F
S
V
A
Q
C
Q
L
M
K
T
E
R
P
R
P
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
T
F
---
T
P
E
E
----
R
E
E
W
T
T
A
I
Q
T
V
A
D
G
L
K
K
Q
-------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
----------
N
R
V
L
-
Q
---
N
-
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
---------------------
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
---
N
---
Q
----
D
H
---
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
-------------------------------------------------------
570
Fugue
85.54
100%
-112
- C2 -
-
5KCV
9.4
-
AKT1_HUMAN
A:
[20-452]
-----
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
-
T
W
R
P
R
Y
F
L
L
K
N
D
G
T
F
I
G
Y
K
E
R
P
-------
A
P
L
N
N
F
S
V
A
Q
C
Q
L
M
K
T
E
R
P
R
P
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
T
F
H
V
E
T
P
E
E
----
R
E
E
W
T
T
A
I
Q
---------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
-------------------
V
L
-
Q
---
N
-
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
-----------------------
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
---
N
---
Q
----
D
H
---
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
----------------------------------------------
10
PsiBlast_PDB
85.36
99%
-112
- C2 -
-
5KCV
-
-
AKT1_HUMAN
A:
[20-452]
-----
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
-
T
W
R
P
R
Y
F
L
L
K
N
D
G
T
F
I
G
Y
K
E
R
P
-------
A
P
L
N
N
F
S
V
A
Q
C
Q
L
M
K
T
E
R
P
R
P
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
T
F
H
V
E
T
P
E
E
----
R
E
E
W
T
T
A
I
Q
---------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
-------------------
V
L
-
Q
---
N
-
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
-----------------------
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
---
N
---
Q
----
D
H
---
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
----------------------------------------------
20
PsiBlast_PDB
81.38
99%
-101
- C2 -
-
4GV1
7.8
-
AKT1_HUMAN
A:
[4-337]
---------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
---
N
-
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
--
A
T
M
K
--
T
-
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
---
N
---
Q
----
D
H
---
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
E
F
T
A
Q
M
I
T
I
T
P
-----
S
M
E
C
V
D
S
E
R
R
P
H
---
F
P
Q
F
D
Y
S
A
S
---
19
PsiBlast_PDB
81.06
99%
-103
- C2 -
-
6BUU
-
-
AKT1_HUMAN
A:
[1-335]
---------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
---
N
-
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
--
A
T
M
K
--
T
-
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
---
N
---
Q
----
D
H
---
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
E
F
T
A
Q
M
I
T
I
T
------------
S
E
R
R
P
H
---
F
P
Q
F
S
Y
S
A
S
G
--
553
HHSearch
81.04
99%
-101
- C2 -
-
4GV1
7.8
-
AKT1_HUMAN
A:
[5-337]
----------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
---
N
-
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
--
A
T
M
K
--
T
-
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
---
N
---
Q
----
D
H
---
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
E
F
T
A
Q
M
I
T
I
T
P
-----
S
M
E
C
V
D
S
E
R
R
P
H
---
F
P
Q
F
D
Y
S
A
S
---
11
PsiBlast_PDB
80.86
99%
-100
- C2 -
-
6NPZ
-
-
AKT1_HUMAN
A:
[20-356]
-------------------------------------------------------------------------------------------------------------------------------------------------
K
H
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
---
N
-
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
--
A
T
M
K
--
T
-
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
---
N
---
Q
----
D
H
---
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
E
F
T
A
Q
M
I
T
I
---------------
R
R
P
H
---
F
P
Q
F
S
Y
S
A
S
G
--
16
PsiBlast_PDB
80.53
99%
-100
- C2 -
-
3QKM
9.6
-
AKT1_HUMAN
A:
[5-339]
---------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
---
N
-
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
--
A
T
M
K
--
T
-
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
---
N
---
Q
----
D
H
---
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
E
F
T
A
Q
M
I
T
I
T
P
-----
S
M
E
C
V
D
S
E
R
R
P
H
---
F
P
Q
F
D
Y
S
A
S
S
--
15
PsiBlast_PDB
80.19
99%
-101
- C2 -
-
3QKL
9.0
-
AKT1_HUMAN
A:
[5-339]
---------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
---
N
-
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
--
A
T
M
K
--
T
-
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
---
N
---
Q
----
D
H
---
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
E
F
T
A
Q
M
I
T
-----------------
R
P
H
---
F
P
Q
F
D
Y
S
A
S
S
--
18
PsiBlast_PDB
80.16
99%
-98
- C2 -
-
4EKL
8.5
-
AKT1_HUMAN
A:
[5-339]
---------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
---
N
-
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
--
A
T
M
K
--
T
-
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
---
N
---
Q
----
D
H
---
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
E
F
T
A
Q
M
I
T
I
T
P
-----
S
M
E
C
V
D
S
E
R
R
P
H
---
F
P
Q
F
D
Y
S
A
S
S
--
14
PsiBlast_PDB
79.85
99%
-98
- C2 -
-
3QKK
7.4
-
AKT1_HUMAN
A:
[5-339]
---------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
---
N
-
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
--
A
T
M
K
--
T
-
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
---
N
---
Q
----
D
H
---
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
E
F
T
A
Q
M
I
T
I
--------
M
E
C
V
D
S
E
R
R
P
H
---
F
P
Q
F
D
Y
S
A
S
S
--
28
Blastp_CBE
79.52
99%
-98
- C2 -
-
3CQU
8.5
-
AKT1_HUMAN
A:
[6-340]
---------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
---
N
-
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
--
A
T
M
K
--
T
-
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
---
N
---
Q
----
D
H
---
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
E
F
T
A
Q
M
----------------
S
E
R
R
P
H
---
F
P
Q
F
D
Y
S
A
S
S
--
27
Blastp_CBE
79.51
99%
-101
- C2 -
-
3CQW
6.4
-
AKT1_HUMAN
A:
[6-340]
---------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
---
N
-
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
--
A
T
M
K
--
T
-
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
---
N
---
Q
----
D
H
---
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
E
F
T
A
Q
M
I
----------------
E
R
R
P
H
---
F
P
Q
F
D
Y
S
A
S
S
--
12
PsiBlast_PDB
79.35
99%
-98
- C2 -
-
3OCB
6.6
-
AKT1_HUMAN
A:
[5-339]
---------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
---
N
-
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
--
A
T
M
K
--
T
-
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
---
N
---
Q
----
D
H
---
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
E
F
T
A
Q
M
-------------------
R
P
H
---
F
P
Q
F
D
Y
S
A
S
S
--
22
Blastp_CBE
79.29
99%
-101
- C2 -
-
4EKK
7.3
-
AKT1_HUMAN
B:
[5-338]
---------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
---
N
-
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
--
A
T
M
K
--
T
-
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
---
N
---
Q
----
D
H
---
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
E
F
T
A
Q
M
I
---------------
S
E
R
R
P
H
---
F
P
Q
F
D
Y
S
A
S
---
23
Blastp_CBE
79.18
99%
-99
- C2 -
-
3OW4
6.7
-
AKT1_HUMAN
B:
[5-339]
---------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
---
N
-
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
--
A
T
M
K
--
T
-
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
---
N
---
Q
----
D
H
---
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
E
F
T
A
Q
M
I
T
-----------------
R
P
H
---
F
P
Q
F
D
Y
S
A
S
S
--
30
Blastp_CBE
79.17
96%
-106
- C2 -
-
6CCY
9.9
-
AKT1_HUMAN
A:
[4-339]
---------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
K
D
E
V
A
H
T
L
T
E
S
R
V
L
-
Q
---
N
-
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
--
A
T
M
K
--
T
-
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
---
N
---
Q
----
D
H
---
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
G
P
-
S
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
V
D
T
R
Y
F
D
-
E
E
F
T
A
Q
M
I
T
I
T
-----------------
E
QEM
F
R
D
F
D
Y
I
A
----
24
Blastp_CBE
78.81
99%
-102
- C2 -
-
3OCB
7.2
-
AKT1_HUMAN
B:
[5-339]
---------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
---
N
-
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
--
A
T
M
K
--
T
-
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
---
N
---
Q
----
D
H
---
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
E
F
T
A
Q
M
I
T
I
T
---------------
R
P
H
---
F
P
Q
F
D
Y
S
A
S
S
--
25
Blastp_CBE
78.74
99%
-97
- C2 -
-
3MVH
7.7
-
AKT1_HUMAN
A:
[7-338]
----------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
---
N
-
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
--
A
T
M
K
--
T
-
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
---
N
---
Q
----
D
H
---
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
E
F
T
A
Q
--------------------
R
P
H
---
F
P
Q
F
D
Y
S
A
----
26
Blastp_CBE
78.70
99%
-98
- C2 -
-
3MV5
5.9
-
AKT1_HUMAN
A:
[6-339]
---------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
---
N
-
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
--
A
T
M
K
--
T
-
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
---
N
---
Q
----
D
H
---
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
E
F
T
A
Q
M
I
------------------
R
P
H
---
F
P
Q
F
D
Y
S
A
S
---
17
PsiBlast_PDB
78.50
99%
-98
- C2 -
-
4EKK
6.9
-
AKT1_HUMAN
A:
[5-338]
---------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
---
N
-
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
--
A
T
M
K
--
T
-
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
---
N
---
Q
----
D
H
---
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
E
F
T
A
Q
M
I
---------------
S
E
R
R
P
H
---
F
P
Q
F
D
Y
S
A
S
---
554
HHSearch
78.34
85%
-110
- C2 -
-
2JDO
6.4
-
AKT2_HUMAN
A:
[6-341]
---------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
---
N
-
T
---
R
-
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
--
A
T
M
K
--
T
-
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
---
N
---
Q
----
D
H
---
E
---
R
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
G
P
-
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
--
P
-----
Q
V
T
S
E
V
D
T
R
Y
F
D
-
D
E
F
T
A
Q
S
I
T
-------------------
M
---
F
E
D
F
D
Y
I
A
D
---
13
PsiBlast_PDB
78.33
99%
-97
- C2 -
-
3OW4
6.9
-
AKT1_HUMAN
A:
[5-339]
---------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
---
N
-
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
--
A
T
M
K
--
T
-
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
---
N
---
Q
----
D
H
---
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
E
F
T
A
Q
M
I
T
-----------------
R
P
H
---
F
P
Q
F
D
Y
S
A
S
S
--
36
Blastp_CBE
78.19
85%
-107
- C2 -
-
3E87
6.9
-
AKT2_HUMAN
B:
[1-333]
---------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
---
N
-
T
---
R
-
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
--
A
T
M
K
--
T
-
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
---
N
---
Q
----
D
H
---
E
---
R
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
G
P
-
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
--
P
-----
Q
V
T
S
E
V
D
T
R
Y
F
D
-
D
E
F
T
A
Q
S
I
T
I
-
P
P
-----------
D
Q
R
T
H
---
F
P
Q
F
D
Y
S
A
S
---
38
Blastp_CBE
78.18
85%
-107
- C2 -
-
3D0E
9.2
-
AKT2_HUMAN
B:
[1-333]
---------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
---
N
-
T
---
R
-
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
--
A
T
M
K
--
T
-
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
---
N
---
Q
----
D
H
---
E
---
R
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
G
P
-
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
--
P
-----
Q
V
T
S
E
V
D
T
R
Y
F
D
-
D
E
F
T
A
Q
S
I
T
I
-
P
P
D
----------
D
Q
R
T
H
---
F
P
Q
F
D
Y
S
A
S
---
34
Blastp_CBE
78.17
85%
-110
- C2 -
-
3E88
9.4
-
AKT2_HUMAN
B:
[1-333]
---------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
---
N
-
T
---
R
-
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
--
A
T
M
K
--
T
-
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
---
N
---
Q
----
D
H
---
E
---
R
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
G
P
-
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
--
P
-----
Q
V
T
S
E
V
D
T
R
Y
F
D
-
D
E
F
T
A
Q
S
I
T
I
--------------
D
Q
R
T
H
---
F
P
Q
F
D
Y
S
A
S
---
37
Blastp_CBE
77.99
85%
-107
- C2 -
-
3E87
6.7
-
AKT2_HUMAN
A:
[1-333]
---------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
---
N
-
T
---
R
-
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
--
A
T
M
K
--
T
-
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
---
N
---
Q
----
D
H
---
E
---
R
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
G
P
-
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
--
P
-----
Q
V
T
S
E
V
D
T
R
Y
F
D
-
D
E
F
T
A
Q
S
I
T
I
-
P
P
-----------
D
Q
R
T
H
---
F
P
Q
F
D
Y
S
A
S
---
35
Blastp_CBE
77.75
85%
-110
- C2 -
-
3E88
9.2
-
AKT2_HUMAN
A:
[1-333]
---------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
---
N
-
T
---
R
-
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
--
A
T
M
K
--
T
-
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
---
N
---
Q
----
D
H
---
E
---
R
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
G
P
-
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
--
P
-----
Q
V
T
S
E
V
D
T
R
Y
F
D
-
D
E
F
T
A
Q
S
I
T
I
--------------
D
Q
R
T
H
---
F
P
Q
F
D
Y
S
A
S
---
31
Blastp_CBE
77.66
86%
-111
- C2 -
-
1O6K
7.8
-
AKT2_HUMAN
A:
[1-333]
---------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
---
N
-
T
---
R
-
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
--
A
T
M
K
--
T
-
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
---
N
---
Q
----
D
H
---
E
---
R
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
G
P
-
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
--
P
-----
Q
V
T
S
E
V
D
T
R
Y
F
D
-
D
E
F
T
A
Q
S
I
T
----------------
Q
R
T
H
---
F
P
Q
F
D
Y
S
A
S
---
44
Blastp_CBE
77.61
84%
-107
- C2 -
-
2JDO
6.4
-
AKT2_HUMAN
A:
[6-340]
---------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
---
N
-
T
---
R
-
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
--
A
T
M
K
--
T
-
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
---
N
---
Q
----
D
H
---
E
---
R
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
G
P
-
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
--
P
-----
Q
V
T
S
E
V
D
T
R
Y
F
D
-
D
E
F
T
A
Q
S
I
T
--------------------M--
F
E
D
F
D
Y
I
A
----
32
Blastp_CBE
77.51
85%
-111
- C2 -
-
3E8D
8.8
-
AKT2_HUMAN
B:
[1-333]
---------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
---
N
-
T
---
R
-
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
--
A
T
M
K
--
T
-
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
---
N
---
Q
----
D
H
---
E
---
R
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
G
P
-
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
--
P
-----
Q
V
T
S
E
V
D
T
R
Y
F
D
-
D
E
F
T
A
Q
S
I
-----------------
Q
R
T
H
---
F
P
Q
F
D
Y
S
A
S
---
33
Blastp_CBE
77.40
85%
-112
- C2 -
-
3E8D
8.4
-
AKT2_HUMAN
A:
[1-333]
---------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
---
N
-
T
---
R
-
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
--
A
T
M
K
--
T
-
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
---
N
---
Q
----
D
H
---
E
---
R
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
G
P
-
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
--
P
-----
Q
V
T
S
E
V
D
T
R
Y
F
D
-
D
E
F
T
A
Q
S
I
-------------------
T
H
---
F
P
Q
F
D
Y
S
A
S
---
39
Blastp_CBE
77.24
85%
-109
- C2 -
-
3D0E
9.2
-
AKT2_HUMAN
A:
[1-333]
---------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
---
N
-
T
---
R
-
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
--
A
T
M
K
--
T
-
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
---
N
---
Q
----
D
H
---
E
---
R
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
G
P
-
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
--
P
-----
Q
V
T
S
E
V
D
T
R
Y
F
D
-
D
E
F
T
A
Q
S
I
T
I
-
P
P
D
----------
D
Q
R
T
H
---
F
P
Q
F
D
Y
S
A
S
---
45
Blastp_CBE
76.57
84%
-112
- C2 -
-
1O6L
7.9
-
AKT2_HUMAN
A:
[1-335]
---------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
---
N
-
T
---
R
-
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
--
A
T
M
K
--
T
-
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
---
N
---
Q
----
D
H
---
E
---
R
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
G
P
-
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
--
P
-----
Q
V
T
S
E
V
D
T
R
Y
F
D
-
D
E
F
T
A
Q
S
I
T
--------------------QEM
F
E
D
F
D
Y
I
A
----
43
Blastp_CBE
76.52
84%
-112
- C2 -
-
2JDR
8.8
-
AKT2_HUMAN
A:
[6-340]
---------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
---
N
-
T
---
R
-
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
--
A
T
M
K
--
T
-
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
---
N
---
Q
----
D
H
---
E
---
R
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
G
P
-
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
--
P
-----
Q
V
T
S
E
V
D
T
R
Y
F
D
-
D
E
F
T
A
Q
S
I
T
--------------------QEM
F
E
D
F
D
Y
I
A
----
42
Blastp_CBE
76.44
84%
-108
- C2 -
-
2UW9
6.5
-
AKT2_HUMAN
A:
[6-340]
---------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
---
N
-
T
---
R
-
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
--
A
T
M
K
--
T
-
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
---
N
---
Q
----
D
H
---
E
---
R
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
G
P
-
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
--
P
-----
Q
V
T
S
E
V
D
T
R
Y
F
D
-
D
E
F
T
A
Q
S
I
T
--------------------QEM
F
E
D
F
D
Y
I
A
----
41
Blastp_CBE
76.33
84%
-109
- C2 -
-
2X39
7.6
-
AKT2_HUMAN
A:
[6-340]
---------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
---
N
-
T
---
R
-
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
--
A
T
M
K
--
T
-
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
---
N
---
Q
----
D
H
---
E
---
R
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
G
P
-
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
--
P
-----
Q
V
T
S
E
V
D
T
R
Y
F
D
-
D
E
F
T
A
Q
S
I
T
--------------------QEM
F
E
D
F
D
Y
I
A
----
40
Blastp_CBE
76.23
84%
-114
- C2 -
-
2XH5
8.5
-
AKT2_HUMAN
A:
[6-340]
---------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
---
N
-
T
---
R
-
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
--
A
T
M
K
--
T
-
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
---
N
---
Q
----
D
H
---
E
---
R
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
G
P
-
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
--
P
-----
Q
V
T
S
E
V
D
T
R
Y
F
D
-
D
E
F
T
A
Q
S
I
T
--------------------QEM
F
E
D
F
D
Y
I
A
----
369
Blastp_CBE
65.48
41%
-95
- C2 -
-
5N1O
5.0
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
----
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
-
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
190
Blastp_CBE
65.24
42%
-83
- C2 -
-
5N7U
4.0
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
209
Blastp_CBE
65.20
42%
-87
- C2 -
-
5LCP
6.1
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
318
Blastp_CBE
65.15
41%
-86
- C2 -
-
6I2H
5.8
-
?
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
191
Blastp_CBE
65.02
42%
-85
- C2 -
-
5N7P
4.4
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
364
Blastp_CBE
64.86
41%
-85
- C2 -
-
5N3A
4.0
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
333
Blastp_CBE
64.70
41%
-89
- C2 -
-
6EH3
5.2
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
324
Blastp_CBE
64.68
41%
-89
- C2 -
-
6ERW
5.6
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
----
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
205
Blastp_CBE
64.67
42%
-90
- C2 -
-
5LCU
5.5
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
196
Blastp_CBE
64.59
42%
-86
- C2 -
-
5MHI
4.0
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
--
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
366
Blastp_CBE
64.54
41%
-86
- C2 -
-
5N37
4.8
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
329
Blastp_CBE
64.50
41%
-88
- C2 -
-
6EMB
6.4
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
198
Blastp_CBE
64.49
42%
-89
- C2 -
-
5M71
5.5
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
330
Blastp_CBE
64.48
41%
-89
- C2 -
-
6EMA
6.4
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
206
Blastp_CBE
64.44
42%
-87
- C2 -
-
5LCT
5.5
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
315
Blastp_CBE
64.41
41%
-89
- C2 -
-
5NW8
5.5
-
KAPCA_CRIGR
A:
[14-330]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
322
Blastp_CBE
64.40
41%
-88
- C2 -
-
6I2A
6.4
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
193
Blastp_CBE
64.38
42%
-84
- C2 -
-
5N1K
3.3
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
--
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
----
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
345
Blastp_CBE
64.34
41%
-89
- C2 -
-
5NTJ
3.8
-
KAPCA_CRIGR
A:
[16-335]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
326
Blastp_CBE
64.36
41%
-88
- C2 -
-
6ERT
5.7
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
207
Blastp_CBE
64.34
42%
-85
- C2 -
-
5LCR
4.9
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
192
Blastp_CBE
64.32
42%
-91
- C2 -
-
5N32
4.8
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
--
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
-
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
321
Blastp_CBE
64.31
41%
-88
- C2 -
-
6I2B
6.3
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
--
G
D
T
S
N
F
D
-
D
-------------------------------------------
371
Blastp_CBE
64.25
41%
-91
- C2 -
-
5N1M
4.0
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
--
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
208
Blastp_CBE
64.29
42%
-85
- C2 -
-
5LCQ
5.6
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
370
Blastp_CBE
64.28
41%
-84
- C2 -
-
5N1N
3.8
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
-
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
360
Blastp_CBE
64.21
41%
-88
- C2 -
-
5N3E
3.8
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
-
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
197
Blastp_CBE
64.24
42%
-90
- C2 -
-
5M75
5.9
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
199
Blastp_CBE
64.23
42%
-84
- C2 -
-
5M6Y
5.9
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
204
Blastp_CBE
64.21
42%
-85
- C2 -
-
5M0B
5.0
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
334
Blastp_CBE
64.20
41%
-93
- C2 -
-
6EH2
5.4
-
KAPCA_CRIGR
A:
[16-335]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
----
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
--
G
D
T
S
N
F
D
-
D
-------------------------------------------
327
Blastp_CBE
64.19
41%
-88
- C2 -
-
6ERS
6.1
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
---
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
201
Blastp_CBE
64.14
42%
-88
- C2 -
-
5M0U
Error
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
-----
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
320
Blastp_CBE
64.08
41%
-87
- C2 -
-
6I2C
6.1
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
---
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
200
Blastp_CBE
64.09
42%
-89
- C2 -
-
5M6V
6.4
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
186
Blastp_CBE
64.08
42%
-87
- C2 -
-
6F14
4.7
-
KAPCA_CRIGR
A:
[14-330]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
-----
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
363
Blastp_CBE
64.04
41%
-87
- C2 -
-
5N3B
3.4
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
-
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
339
Blastp_CBE
64.01
41%
-87
- C2 -
-
5OTG
5.2
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
367
Blastp_CBE
64.00
41%
-87
- C2 -
-
5N36
3.5
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
--
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
194
Blastp_CBE
63.99
42%
-85
- C2 -
-
5N1E
4.1
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
---
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
342
Blastp_CBE
63.91
41%
-86
- C2 -
-
5OK3
6.5
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
195
Blastp_CBE
63.88
42%
-89
- C2 -
-
5N1D
4.9
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
--
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
439
Blastp_CBE
63.80
43%
-102
- C2 -
-
5N23
7.2
-
KAPCA_HUMAN
A:
[41-331]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
R
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
Q
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
K
---
R
V
K
--
G
R
T
P
--
W
-
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
------
S
N
F
D
-
D
-------------------------------------------
368
Blastp_CBE
63.85
41%
-86
- C2 -
-
5N33
3.9
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
--
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
372
Blastp_CBE
63.79
41%
-85
- C2 -
-
5N1L
5.9
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
--
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
337
Blastp_CBE
63.83
41%
-88
- C2 -
-
5OUC
5.0
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
359
Blastp_CBE
63.79
41%
-90
- C2 -
-
5N3F
3.8
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
---
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
--
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
-
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
335
Blastp_CBE
63.79
41%
-84
- C2 -
-
6EGW
6.2
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
---
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
-
G
D
T
S
N
F
D
-
D
-------------------------------------------
331
Blastp_CBE
63.79
41%
-89
- C2 -
-
6EM6
6.8
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
340
Blastp_CBE
63.80
41%
-88
- C2 -
-
5OT3
6.3
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
202
Blastp_CBE
63.79
42%
-83
- C2 -
-
5M0L
4.6
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
357
Blastp_CBE
63.76
41%
-86
- C2 -
-
5N3H
4.1
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
344
Blastp_CBE
63.74
41%
-88
- C2 -
-
5O0E
6.6
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
375
Blastp_CBE
63.68
41%
-86
- C2 -
-
5N1F
4.7
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
319
Blastp_CBE
63.68
41%
-88
- C2 -
-
6I2D
6.1
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
217
Blastp_CBE
63.65
43%
-109
- C2 -
-
4NTT
4.8
-
KAPCA_MOUSE
B:
[35-329]
-------------------------------------------------------------------------------------------------------------------------------------------------
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
218
Blastp_CBE
63.60
43%
-110
- C2 -
-
4NTT
4.5
-
KAPCA_MOUSE
A:
[35-329]
-------------------------------------------------------------------------------------------------------------------------------------------------
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
351
Blastp_CBE
63.56
41%
-88
- C2 -
-
5N3O
4.9
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
361
Blastp_CBE
63.59
41%
-86
- C2 -
-
5N3D
3.7
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
--
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
362
Blastp_CBE
63.57
41%
-85
- C2 -
-
5N3C
3.8
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
-
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
323
Blastp_CBE
63.53
41%
-82
- C2 -
-
6ESA
7.2
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
48
Blastp_CBE
63.55
50%
-135
- C2 -
-
2R5T
6.8
-
SGK1_HUMAN
A:
[38-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
F
H
F
L
K
V
I
G
K
G
-
S
F
G
K
V
L
L
A
R
H
---
K
A
---
E
-
E
----
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
--------------
V
L
L
-
K
---
N
-
V
---
K
-
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
--
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
E
H
N
--
S
T
T
S
--
T
-
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
H
K
Q
---
P
-----
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
-
L
P
P
F
-----
Y
---
S
---
R
----
N
T
---
A
---
E
M
Y
D
N
I
--
L
--
N
K
P
L
--
Q
L
K
-----
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
--
R
L
-
G
A
K
-
D
D
F
-
M
E
-
I
K
S
H
V
F
F
S
L
I
N
---
W
D
D
L
I
N
K
K
I
T
P
P
F
N
--
P
-----
N
V
S
G
-----------------------------------------------------
355
Blastp_CBE
63.54
41%
-84
- C2 -
-
5N3J
4.6
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
301
Blastp_CBE
63.53
44%
-94
- C2 -
-
1RDQ
8.4
-
KAPCA_MOUSE
E:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
A
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
328
Blastp_CBE
63.51
41%
-87
- C2 -
-
6EMD
6.3
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
133
Blastp_CBE
63.50
46%
-99
- C2 -
-
1SMH
3.2
-
KAPCA_BOVIN
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
E
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
L
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
353
Blastp_CBE
63.48
41%
-85
- C2 -
-
5N3L
5.1
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
343
Blastp_CBE
63.47
41%
-86
- C2 -
-
5O5M
6.5
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
--
G
D
T
S
N
F
D
-
D
-------------------------------------------
276
Blastp_CBE
63.46
45%
-104
- C2 -
-
5VIB
7.9
-
KAPCA_BOVIN
A:
[41-350]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
----
D
T
S
N
F
D
-
D
-------------------------------------------
365
Blastp_CBE
63.45
41%
-88
- C2 -
-
5N39
4.8
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
--
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
274
Blastp_CBE
63.41
45%
-97
- C2 -
-
2C1B
6.7
-
KAPCA_BOVIN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
434
Blastp_CBE
63.39
44%
-105
- C2 -
-
4C34
9.4
-
KAPCA_BOVIN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
Y
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
------
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
341
Blastp_CBE
63.34
41%
-86
- C2 -
-
5OL3
6.3
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
414
Blastp_CBE
63.37
44%
-101
- C2 -
-
1Q8W
5.6
-
KAPCA_BOVIN
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
350
Blastp_CBE
63.36
41%
-87
- C2 -
-
5N3P
4.6
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
203
Blastp_CBE
63.34
42%
-83
- C2 -
-
5M0C
4.4
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
237
Blastp_CBE
63.29
45%
-96
- C2 -
-
3DND
4.5
-
KAPCA_BOVIN
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
D
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
269
Blastp_CBE
63.25
45%
-99
- C2 -
-
6E99
7.6
-
KAPCA_BOVIN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
286
Blastp_CBE
63.23
46%
-95
- C2 -
-
2UW0
8.9
-
KAPCA_BOVIN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
352
Blastp_CBE
63.17
41%
-84
- C2 -
-
5N3M
2.4
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
332
Blastp_CBE
63.17
41%
-87
- C2 -
-
6EM2
5.4
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
406
Blastp_CBE
63.20
44%
-98
- C2 -
-
4IAK
7.3
-
KAPCA_MOUSE
A:
[46-335]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
171
Blastp_CBE
63.18
45%
-99
- C2 -
-
2OJF
6.8
-
KAPCA_BOVIN
E:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
---
T
-
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
153
Blastp_CBE
63.18
45%
-98
- C2 -
-
5UZK
9.0
-
KAPCA_HUMAN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
305
Blastp_CBE
63.17
44%
-96
- C2 -
-
2GNH
5.7
-
KAPCA_BOVIN
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
I
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
433
Blastp_CBE
63.14
44%
-102
- C2 -
-
4C35
6.6
-
KAPCA_BOVIN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
Y
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
374
Blastp_CBE
63.08
41%
-82
- C2 -
-
5N1G
2.8
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
233
Blastp_CBE
63.10
44%
-104
- C2 -
-
2ERZ
5.2
-
KAPCA_MOUSE
E:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
354
Blastp_CBE
63.09
41%
-85
- C2 -
-
5N3K
3.9
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
347
Blastp_CBE
63.08
41%
-85
- C2 -
-
5N3S
4.0
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
211
Blastp_CBE
63.07
44%
-106
- C2 -
-
6MM8
3.1
-
KAPCA_MOUSE
C:
[29-338]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
438
Blastp_CBE
62.99
44%
-98
- C2 -
-
6FRX
8.3
-
KAPCA_HUMAN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
R
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
Q
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
-----
S
N
F
D
-
D
-------------------------------------------
386
Blastp_CBE
63.06
44%
-99
- C2 -
-
4DH3
8.1
-
KAPCA_MOUSE
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
125
Blastp_CBE
63.03
46%
-92
- C2 -
-
2UW7
7.5
-
KAPCA_BOVIN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
358
Blastp_CBE
62.98
41%
-85
- C2 -
-
5N3G
4.1
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
270
Blastp_CBE
62.98
45%
-96
- C2 -
-
4IE9
5.0
-
KAPCA_BOVIN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
47
Blastp_CBE
62.99
50%
-126
- C2 -
-
3HDM
7.0
-
SGK1_HUMAN
A:
[38-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
F
H
F
L
K
V
I
G
K
G
-
S
F
G
K
V
L
L
A
R
H
---
K
A
---
E
-
E
----
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
--------------
V
L
L
-
K
---
N
-
V
---
K
-
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
--
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
E
H
N
--
S
T
T
S
--
T
-
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
H
K
Q
---
P
-----
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
-
L
P
P
F
-----
Y
---
S
---
R
----
N
T
---
A
---
E
M
Y
D
N
I
--
L
--
N
K
P
L
--
Q
L
K
-----
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
--
R
L
-
G
A
K
-
D
D
F
-
M
E
-
I
K
S
H
V
F
F
S
L
I
N
---
W
D
D
L
I
N
K
K
I
T
P
P
F
N
--
P
-----
N
V
S
G
-----------------------------------------------------
177
Blastp_CBE
62.98
45%
-93
- C2 -
-
5BX6
4.2
-
KAPCA_HUMAN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
173
Blastp_CBE
62.98
45%
-107
- C2 -
-
2F7Z
7.6
-
KAPCA_BOVIN
E:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
---
T
-
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
283
Blastp_CBE
62.95
46%
-95
- C2 -
-
2UW6
5.9
-
KAPCA_BOVIN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
410
Blastp_CBE
62.90
44%
-97
- C2 -
-
4IAC
7.0
-
KAPCA_MOUSE
A:
[46-335]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
273
Blastp_CBE
62.96
45%
-98
- C2 -
-
2VO7
8.3
-
KAPCA_BOVIN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
267
Blastp_CBE
62.95
45%
-94
- C2 -
-
1SVH
9.3
-
KAPCA_BOVIN
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
175
Blastp_CBE
62.94
45%
-99
- C2 -
-
2F7E
7.5
-
KAPCA_BOVIN
E:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
---
T
-
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
235
Blastp_CBE
62.90
45%
-94
- C2 -
-
4YXR
4.3
-
KAPCA_BOVIN
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
D
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
413
Blastp_CBE
62.91
44%
-96
- C2 -
-
1XH4
9.2
-
KAPCA_BOVIN
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
152
Blastp_CBE
62.90
45%
-98
- C2 -
-
6C0U
8.3
-
KAPCA_HUMAN
A:
[44-333]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
426
Blastp_CBE
62.83
44%
-96
- C2 -
-
3ZO1
6.2
-
KAPCA_BOVIN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
135
Blastp_CBE
62.89
46%
-96
- C2 -
-
4Z84
6.8
-
KAPCA_BOVIN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
124
Blastp_CBE
62.88
46%
-92
- C2 -
-
4AXA
8.2
-
KAPCA_BOVIN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
380
Blastp_CBE
62.83
44%
-97
- C2 -
-
5JR7
5.3
-
KAPCA_MOUSE
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
120
Blastp_CBE
62.87
46%
-101
- C2 -
-
3L9N
7.8
-
KAPCA_HUMAN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
--------
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
278
Blastp_CBE
62.84
46%
-93
- C2 -
-
2VO6
8.2
-
KAPCA_BOVIN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
401
Blastp_CBE
62.79
44%
-97
- C2 -
-
4IB3
7.0
-
KAPCA_MOUSE
A:
[46-335]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
275
Blastp_CBE
62.84
45%
-98
- C2 -
-
2C1A
6.7
-
KAPCA_BOVIN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
316
Blastp_CBE
62.81
41%
-83
- C2 -
-
6EM7
8.7
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
46
Blastp_CBE
62.83
50%
-136
- C2 -
-
3HDN
7.0
-
SGK1_HUMAN
A:
[38-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
F
H
F
L
K
V
I
G
K
G
-
S
F
G
K
V
L
L
A
R
H
---
K
A
---
E
-
E
----
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
--------------
V
L
L
-
K
---
N
-
V
---
K
-
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
--
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
E
H
N
--
S
T
T
S
--
T
-
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
H
K
Q
---
P
-----
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
-
L
P
P
F
-----
Y
---
S
---
R
----
N
T
---
A
---
E
M
Y
D
N
I
--
L
--
N
K
P
L
--
Q
L
K
-----
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
--
R
L
-
G
A
K
-
D
D
F
-
M
E
-
I
K
S
H
V
F
F
S
L
I
N
---
W
D
D
L
I
N
K
K
I
T
P
P
F
N
--
P
--------------------------------------------------------------
256
Blastp_CBE
62.81
45%
-98
- C2 -
-
1SVG
9.5
-
KAPCA_BOVIN
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
172
Blastp_CBE
62.81
45%
-99
- C2 -
-
2OH0
7.3
-
KAPCA_BOVIN
E:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
---
T
-
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
373
Blastp_CBE
62.76
41%
-85
- C2 -
-
5N1H
4.8
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
266
Blastp_CBE
62.80
45%
-98
- C2 -
-
1XH5
9.0
-
KAPCA_BOVIN
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
176
Blastp_CBE
62.79
45%
-94
- C2 -
-
5BX7
4.2
-
KAPCA_HUMAN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
423
Blastp_CBE
62.72
44%
-97
- C2 -
-
1XH7
9.4
-
KAPCA_BOVIN
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
236
Blastp_CBE
62.78
45%
-96
- C2 -
-
3DNE
5.9
-
KAPCA_BOVIN
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
D
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
147
Blastp_CBE
62.76
45%
-102
- C2 -
-
2UZT
7.5
-
KAPCA_BOVIN
A:
[26-315]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
---
T
-
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
D
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
129
Blastp_CBE
62.76
46%
-92
- C2 -
-
2JDT
6.7
-
KAPCA_BOVIN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
262
Blastp_CBE
62.72
45%
-101
- C2 -
-
4IJ9
7.5
-
KAPCA_BOVIN
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
382
Blastp_CBE
62.68
44%
-99
- C2 -
-
4HPU
7.5
-
KAPCA_MOUSE
E:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
228
Blastp_CBE
62.72
44%
-103
- C2 -
-
1REJ
6.7
-
KAPCA_MOUSE
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
292
Blastp_CBE
62.71
44%
-96
- C2 -
-
2GNJ
5.3
-
KAPCA_BOVIN
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
I
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
393
Blastp_CBE
62.70
44%
-96
- C2 -
-
3X2U
6.7
-
KAPCA_MOUSE
A:
[47-336]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
280
Blastp_CBE
62.65
46%
-95
- C2 -
-
2VNY
6.1
-
KAPCA_BOVIN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
279
Blastp_CBE
62.69
46%
-94
- C2 -
-
2VO3
8.0
-
KAPCA_BOVIN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
226
Blastp_CBE
62.68
44%
-95
- C2 -
-
3FJQ
9.6
-
KAPCA_MOUSE
E:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
136
Blastp_CBE
62.68
46%
-93
- C2 -
-
4Z83
8.1
-
KAPCA_BOVIN
E:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
167
Blastp_CBE
62.67
45%
-99
- C2 -
-
3OOG
4.5
-
KAPCA_HUMAN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
128
Blastp_CBE
62.66
46%
-97
- C2 -
-
2JDV
9.2
-
KAPCA_BOVIN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
234
Blastp_CBE
62.65
45%
-96
- C2 -
-
4YXS
5.8
-
KAPCA_BOVIN
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
D
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
349
Blastp_CBE
62.64
41%
-85
- C2 -
-
5N3Q
4.1
-
KAPCA_CRIGR
A:
[16-332]
-----------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
-
K
W
E
S
P
S
Q
N
T
A
---------------
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
227
Blastp_CBE
62.61
44%
-105
- C2 -
-
1REK
10.2
-
KAPCA_MOUSE
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
390
Blastp_CBE
62.56
44%
-97
- C2 -
-
2QCS
9.1
-
KAPCA_MOUSE
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
122
Blastp_CBE
62.61
46%
-99
- C2 -
-
3L9M
7.8
-
KAPCA_HUMAN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
123
Blastp_CBE
62.60
46%
-95
- C2 -
-
1XH9
10.0
-
KAPCA_BOVIN
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
E
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
L
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
409
Blastp_CBE
62.59
44%
-96
- C2 -
-
4IAD
7.7
-
KAPCA_MOUSE
A:
[46-335]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
377
Blastp_CBE
62.58
44%
-101
- C2 -
-
3TNQ
5.6
-
KAPCA_MOUSE
B:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
174
Blastp_CBE
62.56
45%
-94
- C2 -
-
2F7X
7.1
-
KAPCA_BOVIN
E:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
---
T
-
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
260
Blastp_CBE
62.54
45%
-95
- C2 -
-
1Q8T
4.4
-
KAPCA_BOVIN
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
161
Blastp_CBE
62.54
45%
-95
- C2 -
-
4UJ1
6.6
-
KAPCA_HUMAN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
144
Blastp_CBE
62.53
45%
-98
- C2 -
-
2UZW
5.5
-
KAPCA_BOVIN
E:
[26-315]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
---
T
-
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
D
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
427
Blastp_CBE
62.46
44%
-92
- C2 -
-
2JDS
7.5
-
KAPCA_BOVIN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
415
Blastp_CBE
62.52
43%
-95
- C2 -
-
4X6R
7.7
-
KAPCA_MOUSE
A:
[35-329]
-------------------------------------------------------------------------------------------------------------------------------------------------
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
302
Blastp_CBE
62.50
43%
-100
- C2 -
-
2QUR
5.2
-
KAPCA_MOUSE
A:
[35-329]
-------------------------------------------------------------------------------------------------------------------------------------------------
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
P
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
A
D
-
D
-------------------------------------------
231
Blastp_CBE
62.48
44%
-102
- C2 -
-
1FMO
6.1
-
KAPCA_MOUSE
E:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
132
Blastp_CBE
62.48
46%
-93
- C2 -
-
1XHA
10.0
-
KAPCA_BOVIN
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
E
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
L
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
259
Blastp_CBE
62.47
45%
-96
- C2 -
-
1Q8U
5.9
-
KAPCA_BOVIN
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
229
Blastp_CBE
62.46
44%
-99
- C2 -
-
1RE8
7.7
-
KAPCA_MOUSE
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
387
Blastp_CBE
62.40
44%
-100
- C2 -
-
4DH1
7.6
-
KAPCA_MOUSE
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
397
Blastp_CBE
62.38
44%
-96
- C2 -
-
6E21
7.3
-
KAPCA_MOUSE
A:
[46-335]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
389
Blastp_CBE
62.38
44%
-98
- C2 -
-
4DG0
6.7
-
KAPCA_MOUSE
E:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
288
Blastp_CBE
62.43
46%
-94
- C2 -
-
2UVY
7.0
-
KAPCA_BOVIN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
130
Blastp_CBE
62.42
46%
-89
- C2 -
-
2VO0
7.9
-
KAPCA_BOVIN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
160
Blastp_CBE
62.41
45%
-95
- C2 -
-
4UJ2
6.6
-
KAPCA_HUMAN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
166
Blastp_CBE
62.40
45%
-95
- C2 -
-
3OVV
6.6
-
KAPCA_HUMAN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
396
Blastp_CBE
62.33
44%
-101
- C2 -
-
4O21
7.0
-
KAPCA_MOUSE
A:
[32-321]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
436
Blastp_CBE
62.31
44%
-94
- C2 -
-
4C37
6.7
-
KAPCA_BOVIN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
Y
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
281
Blastp_CBE
62.38
46%
-91
- C2 -
-
2VNW
6.2
-
KAPCA_BOVIN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
271
Blastp_CBE
62.37
45%
-95
- C2 -
-
3ZO4
7.7
-
KAPCA_BOVIN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
220
Blastp_CBE
62.36
44%
-97
- C2 -
-
4HPT
5.8
-
KAPCA_MOUSE
E:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
265
Blastp_CBE
62.35
45%
-97
- C2 -
-
1XH6
8.7
-
KAPCA_BOVIN
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
303
Blastp_CBE
62.34
44%
-97
- C2 -
-
2GNF
4.9
-
KAPCA_BOVIN
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
I
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
294
Blastp_CBE
62.31
44%
-99
- C2 -
-
3AMA
7.6
-
KAPCA_HUMAN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
R
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
Q
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
-----
S
N
F
D
-
D
-------------------------------------------
169
Blastp_CBE
62.33
45%
-98
- C2 -
-
3L9L
8.0
-
KAPCA_HUMAN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
384
Blastp_CBE
62.32
44%
-98
- C2 -
-
4DH7
9.2
-
KAPCA_MOUSE
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
385
Blastp_CBE
62.26
44%
-97
- C2 -
-
4DH5
7.4
-
KAPCA_MOUSE
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
179
Blastp_CBE
62.31
45%
-96
- C2 -
-
3VQH
7.2
-
KAPCA_HUMAN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
257
Blastp_CBE
62.29
45%
-98
- C2 -
-
1SVE
8.1
-
KAPCA_BOVIN
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
164
Blastp_CBE
62.29
45%
-97
- C2 -
-
3OXT
6.4
-
KAPCA_HUMAN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
421
Blastp_CBE
62.21
45%
-95
- C2 -
-
4WB7
9.0
-
DNJB1_HUMAN (first)
A:
[95-384]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
300
Blastp_CBE
62.26
44%
-97
- C2 -
-
3FHI
9.7
-
KAPCA_MOUSE
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
A
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
121
Blastp_CBE
62.24
46%
-100
- C2 -
-
3L9M
8.0
-
KAPCA_HUMAN
B:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
408
Blastp_CBE
62.16
44%
-94
- C2 -
-
4IAF
7.8
-
KAPCA_MOUSE
A:
[46-335]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
402
Blastp_CBE
62.16
44%
-96
- C2 -
-
4IB1
8.0
-
KAPCA_MOUSE
A:
[46-335]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
187
Blastp_CBE
62.21
45%
-98
- C2 -
-
1YDT
6.8
-
KAPCA_BOVIN
E:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
D
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
304
Blastp_CBE
62.18
44%
-92
- C2 -
-
2GNI
5.9
-
KAPCA_BOVIN
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
I
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
404
Blastp_CBE
62.20
44%
-97
- C2 -
-
4IAZ
7.3
-
KAPCA_MOUSE
A:
[46-335]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
381
Blastp_CBE
62.15
44%
-99
- C2 -
-
4WBB
5.6
-
KAPCA_MOUSE
B:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
165
Blastp_CBE
62.19
45%
-94
- C2 -
-
3OWP
5.9
-
KAPCA_HUMAN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
287
Blastp_CBE
62.18
46%
-96
- C2 -
-
2UVZ
7.7
-
KAPCA_BOVIN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
312
Blastp_CBE
62.15
45%
-94
- C2 -
-
4WB5
8.8
-
KAPCA_HUMAN
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
261
Blastp_CBE
62.17
44%
-96
- C2 -
-
2GU8
7.4
-
KAPCA_HUMAN
A:
[27-316]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
E
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
398
Blastp_CBE
62.16
44%
-97
- C2 -
-
4XW6
7.5
-
KAPCA_MOUSE
A:
[46-335]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
185
Blastp_CBE
62.15
44%
-92
- C2 -
-
1JBP
5.9
-
KAPCA_MOUSE
E:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
E
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
163
Blastp_CBE
62.15
45%
-96
- C2 -
-
3P0M
6.6
-
KAPCA_HUMAN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
425
Blastp_CBE
62.08
44%
-95
- C2 -
-
3ZO3
7.2
-
KAPCA_BOVIN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
391
Blastp_CBE
62.13
44%
-98
- C2 -
-
3X2W
7.7
-
KAPCA_MOUSE
A:
[47-336]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
162
Blastp_CBE
62.12
45%
-97
- C2 -
-
3POO
7.6
-
KAPCA_HUMAN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
----
D
T
S
N
F
D
-
D
-------------------------------------------
430
Blastp_CBE
62.05
44%
-96
- C2 -
-
4DG3
8.1
-
KAPCA_MOUSE
E:
[61-350]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
432
Blastp_CBE
61.97
44%
-94
- C2 -
-
4C36
6.0
-
KAPCA_BOVIN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
Y
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
189
Blastp_CBE
62.11
45%
-98
- C2 -
-
1YDR
5.1
-
KAPCA_BOVIN
E:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
D
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
405
Blastp_CBE
62.04
44%
-98
- C2 -
-
4IAY
6.4
-
KAPCA_MOUSE
A:
[46-335]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
291
Blastp_CBE
62.10
44%
-96
- C2 -
-
2GNL
5.3
-
KAPCA_BOVIN
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
I
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
411
Blastp_CBE
62.08
44%
-95
- C2 -
-
3KKV
7.6
-
KAPCA_BOVIN
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
158
Blastp_CBE
62.05
45%
-93
- C2 -
-
4UJA
7.2
-
KAPCA_HUMAN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
264
Blastp_CBE
62.04
45%
-96
- C2 -
-
1XH8
10.2
-
KAPCA_BOVIN
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
255
Blastp_CBE
62.03
45%
-96
- C2 -
-
1VEB
7.9
-
KAPCA_BOVIN
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
424
Blastp_CBE
62.02
44%
-100
- C2 -
-
5VHB
7.5
-
KAPCA_BOVIN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
------------
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
168
Blastp_CBE
62.01
45%
-97
- C2 -
-
3L9L
8.1
-
KAPCA_HUMAN
B:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
282
Blastp_CBE
61.97
46%
-92
- C2 -
-
2UW8
4.5
-
KAPCA_BOVIN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
378
Blastp_CBE
61.94
44%
-94
- C2 -
-
1L3R
7.0
-
KAPCA_MOUSE
E:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
383
Blastp_CBE
61.92
44%
-96
- C2 -
-
4DH8
9.0
-
KAPCA_MOUSE
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
242
Blastp_CBE
61.95
44%
-99
- C2 -
-
3O7L
5.8
-
KAPCA_MOUSE
B:
[40-333]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
----
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
I
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
I
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
212
Blastp_CBE
61.96
44%
-99
- C2 -
-
6MM7
2.7
-
KAPCA_MOUSE
D:
[29-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
126
Blastp_CBE
61.95
46%
-94
- C2 -
-
2UW4
5.5
-
KAPCA_BOVIN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
-
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
285
Blastp_CBE
61.94
46%
-91
- C2 -
-
2UW3
5.2
-
KAPCA_BOVIN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
392
Blastp_CBE
61.87
44%
-96
- C2 -
-
3X2V
7.9
-
KAPCA_MOUSE
A:
[47-336]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
224
Blastp_CBE
61.92
44%
-100
- C2 -
-
3IDC
6.8
-
KAPCA_MOUSE
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
299
Blastp_CBE
61.89
44%
-99
- C2 -
-
3QAL
9.3
-
KAPCA_MOUSE
E:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
A
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
422
Blastp_CBE
61.91
44%
-96
- C2 -
-
3ZO2
6.3
-
KAPCA_BOVIN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
293
Blastp_CBE
61.89
44%
-97
- C2 -
-
3AMB
7.8
-
KAPCA_HUMAN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
R
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
Q
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
-----
S
N
F
D
-
D
-------------------------------------------
284
Blastp_CBE
61.88
46%
-91
- C2 -
-
2UW5
6.9
-
KAPCA_BOVIN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
232
Blastp_CBE
61.87
44%
-98
- C2 -
-
1ATP
9.1
-
KAPCA_MOUSE
E:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
268
Blastp_CBE
61.83
45%
-97
- C2 -
-
6E9L
7.4
-
KAPCA_BOVIN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
225
Blastp_CBE
61.83
44%
-96
- C2 -
-
3IDB
7.5
-
KAPCA_MOUSE
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
146
Blastp_CBE
61.80
45%
-96
- C2 -
-
2UZU
6.1
-
KAPCA_BOVIN
E:
[26-315]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
---
T
-
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
D
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
309
Blastp_CBE
61.79
45%
-93
- C2 -
-
4WB8
8.5
-
KAPCA_HUMAN
A:
[27-316]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
145
Blastp_CBE
61.78
45%
-93
- C2 -
-
2UZV
7.5
-
KAPCA_BOVIN
A:
[26-315]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
---
T
-
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
D
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
399
Blastp_CBE
61.77
44%
-96
- C2 -
-
4XW5
7.6
-
KAPCA_MOUSE
A:
[46-335]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
222
Blastp_CBE
61.76
44%
-97
- C2 -
-
3OW3
4.1
-
KAPCA_MOUSE
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
412
Blastp_CBE
61.74
44%
-95
- C2 -
-
3BWJ
10.4
-
KAPCA_BOVIN
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
149
Blastp_CBE
61.71
45%
-99
- C2 -
-
1CDK
8.4
-
KAPCA_PIG
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
F
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
Y
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
D
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
170
Blastp_CBE
61.69
45%
-95
- C2 -
-
3AGM
8.3
-
KAPCA_HUMAN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
435
Blastp_CBE
61.68
44%
-97
- C2 -
-
4C38
6.2
-
KAPCA_BOVIN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
Y
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
403
Blastp_CBE
61.58
44%
-96
- C2 -
-
4IB0
7.9
-
KAPCA_MOUSE
A:
[46-335]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
295
Blastp_CBE
61.62
44%
-94
- C2 -
-
3QAM
8.0
-
KAPCA_MOUSE
E:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
A
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
407
Blastp_CBE
61.60
44%
-92
- C2 -
-
4IAI
8.2
-
KAPCA_MOUSE
A:
[46-335]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
181
Blastp_CBE
61.58
45%
-91
- C2 -
-
3AGL
9.2
-
KAPCA_HUMAN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
238
Blastp_CBE
61.57
44%
-102
- C2 -
-
1BX6
7.1
-
KAPCA_MOUSE
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
184
Blastp_CBE
61.55
45%
-89
- C2 -
-
3MVJ
5.6
-
KAPCA_HUMAN
A:
[61-350]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
417
Blastp_CBE
61.53
43%
-93
- C2 -
-
4DFX
8.0
-
KAPCA_MOUSE
E:
[35-329]
-------------------------------------------------------------------------------------------------------------------------------------------------
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
180
Blastp_CBE
61.44
45%
-90
- C2 -
-
3AGL
9.4
-
KAPCA_HUMAN
B:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
142
Blastp_CBE
61.43
45%
-98
- C2 -
-
1Q24
8.6
-
KAPCA_BOVIN
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
127
Blastp_CBE
61.38
46%
-95
- C2 -
-
2UVX
4.4
-
KAPCA_BOVIN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
178
Blastp_CBE
61.35
45%
-90
- C2 -
-
4UJB
6.9
-
KAPCA_HUMAN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
420
Blastp_CBE
61.30
45%
-91
- C2 -
-
4WB7
8.6
-
KAPCA_HUMAN
B:
[95-384]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
400
Blastp_CBE
61.11
44%
-91
- C2 -
-
4XW4
7.3
-
KAPCA_MOUSE
A:
[46-335]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
376
Blastp_CBE
61.10
44%
-100
- C2 -
-
3PVB
7.6
-
KAPCA_MOUSE
A:
[35-324]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
182
Blastp_CBE
61.09
45%
-95
- C2 -
-
3MVJ
5.4
-
KAPCA_HUMAN
E:
[61-350]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
289
Blastp_CBE
61.05
45%
-91
- C2 -
-
4WB6
9.1
-
KAPCA_HUMAN
B:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
R
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
272
Blastp_CBE
61.02
45%
-99
- C2 -
-
3AG9
8.1
-
KAPCA_BOVIN
B:
[41-350]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
221
Blastp_CBE
60.73
44%
-96
- C2 -
-
4DIN
7.5
-
KAPCA_MOUSE
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
148
Blastp_CBE
60.71
45%
-95
- C2 -
-
1CDK
9.1
-
KAPCA_PIG
B:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
F
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
Y
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
D
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
431
Blastp_CBE
60.70
44%
-93
- C2 -
-
4WB6
8.6
-
KAPCA_HUMAN
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
R
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
379
Blastp_CBE
60.65
44%
-94
- C2 -
-
5JR7
5.8
-
KAPCA_MOUSE
C:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
214
Blastp_CBE
60.58
44%
-99
- C2 -
-
6MM6
3.3
-
KAPCA_MOUSE
E:
[29-338]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
239
Blastp_CBE
59.81
44%
-97
- C2 -
-
1BKX
5.6
-
KAPCA_MOUSE
A:
[40-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
296
Blastp_CBE
59.70
45%
-97
- C2 -
-
3NX8
2.4
-
KAPCA_HUMAN
A:
[41-330]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
K
G
--
R
T
W
T
----
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
---
A
---
D
----
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
N
G
V
-
N
D
-
I
L
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-------------------------------------------
475
Blastp_CBE
59.15
37%
-105
- C2 -
-
2R7B
6.7
-
PDPK1_HUMAN
A:
[34-309]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
--------------
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
---
A
---
G
----
N
E
---
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
-------------------------------------------------------------------
92
Blastp_CBE
58.68
48%
-35
- C2 -
-
4Q9Z
6.0
-
KPCT_HUMAN
A:
[2-298]
----------------------------------------------------------------------------------------------------------------------------------------------------
L
K
I
E
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
F
---
K
K
---
T
-
N
----
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
--
M
D
D
D
V
E
C
T
M
V
E
K
R
V
L
-
S
---
L
-
A
W--
E
-
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
--
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
D
--
A
K
T
N
--
E
-
F
-
C
-
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
---
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
-
Q
S
P
F
-----
H
---
G
---
Q
----
D
E
---
E
---
E
L
F
H
S
I
--
R
--
M
D
N
P
--
F
Y
P
-----
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
G
V
R
G
------
D
-
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
--
P
-----
K
V
K
S
P
F
D
C
S
N
F
D
-
K
E
F
L
N
E
--------------------------------------
555
HHSearch
58.60
46%
-26
- C2 -
-
4RA5
6.7
-
KPCT_HUMAN
A:
[3-328]
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
I
E
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
F
---
K
K
---
T
-
N
----
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
--
M
D
D
D
V
E
C
T
M
V
E
K
R
V
L
-
S
L--
A
-
W
---
E
-
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
--
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
K
-
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
D
--
A
K
T
N
--
E
-
F
-
C
-
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
---
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
-
Q
S
P
F
-----
H
---
G
---
Q
----
D
E
---
E
---
E
L
F
H
S
I
--
R
--
M
D
N
P
--
F
Y
P
-----
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
G
V
-----
R
-
G
D
-
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
--
P
-----
K
V
K
S
P
F
D
C
S
N
F
D
-
K
E
F
L
N
E
K
P
R
L
S
F
A
D
R
A
L
----
I
N
S
M
D
Q
N
M
---
F
R
N
F
S
F
M
N
P
G
M
-
90
Blastp_CBE
58.53
48%
-36
- C2 -
-
4RA5
6.7
-
KPCT_HUMAN
A:
[1-298]
---------------------------------------------------------------------------------------------------------------------------------------------------
K
L
K
I
E
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
F
---
K
K
---
T
-
N
----
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
--
M
D
D
D
V
E
C
T
M
V
E
K
R
V
L
-
S
---
L
-
A
W--
E
-
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
--
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
D
--
A
K
T
N
--
E
-
F
-
C
-
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
---
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
-
Q
S
P
F
-----
H
---
G
---
Q
----
D
E
---
E
---
E
L
F
H
S
I
--
R
--
M
D
N
P
--
F
Y
P
-----
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
G
V
R
G
------
D
-
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
--
P
-----
K
V
K
S
P
F
D
C
S
N
F
D
-
K
E
F
L
N
E
--------------------------------------
96
Blastp_CBE
58.52
48%
-33
- C2 -
-
5F9E
8.7
-
KPCT_HUMAN
A:
[15-312]
---------------------------------------------------------------------------------------------------------------------------------------------------
K
L
K
I
E
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
F
---
K
K
---
T
-
N
----
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
--
M
D
D
D
V
E
C
T
M
V
E
K
R
V
L
-
S
---
L
-
A
W--
E
-
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
--
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
D
--
A
K
T
N
--
E
-
F
-
C
-
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
---
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
-
Q
S
P
F
-----
H
---
G
---
Q
----
D
E
---
E
---
E
L
F
H
S
I
--
R
--
M
D
N
P
--
F
Y
P
-----
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
G
V
R
G
------
D
-
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
--
P
-----
K
V
K
S
P
F
D
C
S
N
F
D
-
K
E
F
L
N
E
--------------------------------------
512
Blastp_CBE
58.26
37%
-102
- C2 -
-
1UU3
8.2
-
PDPK1_HUMAN
A:
[31-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
-------------
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
---
A
---
G
----
N
E
---
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
-------------------------------------------------------------------
482
Blastp_CBE
58.19
37%
-97
- C2 -
-
2PE2
2.9
-
PDPK1_HUMAN
A:
[8-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
-------------
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
---
A
---
G
----
N
E
---
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
-------------------------------------------------------------------
524
Blastp_CBE
58.15
37%
-99
- C2 -
-
3QCY
8.8
-
PDPK1_HUMAN
A:
[34-309]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
---------------
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
---
A
---
G
----
N
E
---
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
-------------------------------------------------------------------
523
Blastp_CBE
58.10
37%
-96
- C2 -
-
3QD0
8.6
-
PDPK1_HUMAN
A:
[34-309]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
-----------------
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
---
A
---
G
----
N
E
---
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
-------------------------------------------------------------------
572
Fugue
58.07
34%
-24
- C2 -
-
4AW2
2.2
-
MRCKA_RAT
A:
[1-416]
--------------------------------
S
G
E
V
R
L
R
Q
L
E
Q
F
I
L
D
G
P
A
Q
T
N
G
-------------------------------
Q
C
F
S
V
E
T
--
L
----
L
D
I
L
I
C
L
Y
D
E
C
N
N
S
P
L
R
R
E
K
N
I
L
E
Y
L
E
W
A
K
P
F
T
S
K
V
K
Q
M
---------
R
L
H
R
E
D
F
E
I
L
K
V
I
G
R
G
-
A
F
G
E
V
A
V
V
K
L
---
K
N
---
A
-
D
----
K
V
F
A
M
K
I
L
N
K
W
E
M
L
--
K
R
A
E
T
A
C
F
R
E
E
R
D
V
L
-
V
---
N
-
G
---
D
-
S
K
W
I
T
T
L
H
Y
A
F
Q
D
D
N
N
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F-
E
D
R
L
P
E
E
M
A
R
F
Y
L
A
E
M
V
I
A
I
D
S
V
H
Q
-
L
H
Y
V
H
R
D
I
K
P
D
N
I
L
M
D
-
M
N
G
H
I
R
L
A
D
F
G
S
C
L
K
L
M
E
D
G
--
T
V
Q
S
--
S
-
V
A
V
-
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
---
E
GGKGR
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
-
E
T
P
F
-----
Y
---
A
---
E
----
S
L
---
V
---
E
T
Y
G
K
I
--
M
--
N
H
K
E
--
R
F
Q
FPTQV
T
D
V
S
E
N
A
K
D
L
I
R
R
L
I
C
-
S
R
E
H
--
R
L
G
--
Q
-
N
G
I
-
E
D
-
F
K
K
H
P
F
F
S
G
I
D
---
W
D
N
I
R
N
C
E
--
A
P
Y
I
--
P
-----
E
V
S
S
P
T
D
T
S
N
F
D
----------------------
V
D
S
G
H
H
L
P
---
F
V
G
F
T
Y
T
S
S
C
V
L
483
Blastp_CBE
57.94
37%
-95
- C2 -
-
2PE1
6.0
-
PDPK1_HUMAN
A:
[8-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
-------------
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
---
A
---
G
----
N
E
---
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
-------------------------------------------------------------------
474
Blastp_CBE
57.82
37%
-101
- C2 -
-
3ION
9.4
-
PDPK1_HUMAN
A:
[34-309]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
---------------
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
---
A
---
G
----
N
E
---
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
-------------------------------------------------------------------
485
Blastp_CBE
57.66
37%
-96
- C2 -
-
1Z5M
6.8
-
PDPK1_HUMAN
A:
[8-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
-------------
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
---
A
---
G
----
N
E
---
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
-------------------------------------------------------------------
521
Blastp_CBE
57.53
37%
-96
- C2 -
-
3QD4
8.7
-
PDPK1_HUMAN
A:
[34-309]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
-----------------
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
---
A
---
G
----
N
E
---
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
-------------------------------------------------------------------
484
Blastp_CBE
57.51
37%
-97
- C2 -
-
2PE0
5.3
-
PDPK1_HUMAN
A:
[8-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
-------------
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
---
A
---
G
----
N
E
---
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
-------------------------------------------------------------------
567
HHSearch
57.31
46%
-24
- C2 -
-
5LI9
6.8
-
KPCI_HUMAN
A:
[4-342]
-----------------------------------------------------------------------------------------------------------------------------------------------------
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
---
K
K
---
T
-
D
----
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
--
D
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
-
E
---
Q
-
A
S--
N
-
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
P
G
--
D
T
T
S
--
T
-
F
-
C
-
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
------------------------TED
Y
L
F
Q
V
I
--
L
--
E
K
Q
I
--
R
I
P
-----
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
H
P
Q
T
G
F
-
A
D
-
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
--
P
-----
N
I
S
G
E
F
G
L
D
N
F
D
-
S
Q
F
T
N
E
P
V
Q
L
T
P
D
D
D
D
I
-
V
---
R
K
I
D
Q
S
E
---
F
E
G
F
E
Y
I
N
P
L
--
91
Blastp_CBE
57.25
48%
-29
- C2 -
-
4Q9Z
5.3
-
B:
[1-320]
---------------------------------------------------------------------------------------------------------------------------------------------------
K
L
K
I
E
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
F
---
K
K
---
T
-
N
----
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
--
M
D
D
D
V
E
C
T
M
V
E
K
R
V
L
-
S
---
L
-
A
W--
E
-
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
--
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
D
--
A
K
T
N
--
E
-
F
-
C
-
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
---
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
-
Q
S
P
F
-----
H
---
G
---
Q
----
D
E
---
E
---
E
L
F
H
S
I
--
R
--
M
D
N
P
--
F
Y
P
-----
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
G
V
R
G
------
D
-
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
--
P
-----
K
V
K
S
P
F
D
C
S
N
F
D
-
K
E
F
L
N
E
--------------------------------------
89
Blastp_CBE
57.07
48%
-37
- C2 -
-
4RA5
6.2
-
B:
[2-320]
----------------------------------------------------------------------------------------------------------------------------------------------------
L
K
I
E
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
F
---
K
K
---
T
-
N
----
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
--
M
D
D
D
V
E
C
T
M
V
E
K
R
V
L
-
S
---
L
-
A
W--
E
-
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
--
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
D
--
A
K
T
N
--
E
-
F
-
C
-
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
---
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
-
Q
S
P
F
-----
H
---
G
---
Q
----
D
E
---
E
---
E
L
F
H
S
I
--
R
--
M
D
N
P
--
F
Y
P
-----
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
G
V
R
G
------
D
-
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
--
P
-----
K
V
K
S
P
F
D
C
S
N
F
D
-
K
E
F
L
N
E
--------------------------------------
536
Blastp_CBE
57.02
37%
-97
- C2 -
-
3PWY
3.2
-
PDPK1_HUMAN
A:
[33-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
C
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
P
----------
S
-
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
S
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
---
A
---
G
----
N
E
---
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
-------------------------------------------------------------------
530
Blastp_CBE
57.01
37%
-91
- C2 -
-
3QC4
10.0
-
PDPK1_HUMAN
A:
[36-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
P
E
S
----------
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
---
A
---
G
----
N
E
---
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
A
A
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
-------------------------------------------------------------------
529
Blastp_CBE
56.89
37%
-95
- C2 -
-
3QC4
9.5
-
PDPK1_HUMAN
B:
[36-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
----------
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
P
E
S
----------
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
---
A
---
G
----
N
E
---
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
A
A
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
-------------------------------------------------------------------
560
HHSearch
56.65
46%
-34
- C2 -
-
3TXO
6.1
-
KPCL_HUMAN
A:
[23-349]
-------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
F
E
F
I
R
V
L
G
K
G
-
S
F
G
K
V
M
L
A
R
V
---
K
E
---
T
-
G
----
D
L
Y
A
V
K
V
L
K
K
D
V
I
L
--
Q
D
D
D
V
E
C
T
M
T
E
K
R
I
L
-
S
---
L
-
A
R--
N
-
H
P
F
L
T
Q
L
F
C
C
F
Q
T
P
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
--
S
R
R
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
K
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
H
E
G
H
C
K
L
A
D
F
G
M
C
K
E
G
I
---------------
C
-
G
T
P
D
Y
I
A
P
E
I
L
Q
E
M
---
L
-----
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
-
H
A
P
F
-----
E
---
A
---
E
----
N
E
---
D
---
D
L
F
E
A
I
--
L
--
N
D
E
V
--
V
Y
P
-----
T
W
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
--
R
L
G
S
L
T
Q
G
G
E
-
H
A
-
I
L
R
H
P
F
F
K
E
I
D
---
W
A
Q
L
N
H
R
Q
I
E
P
P
F
R
--
P
-----
R
I
K
S
R
E
D
V
S
N
F
D
-
P
D
F
I
K
E
E
P
V
L
T
P
I
D
E
G
H
----
L
P
M
I
N
Q
D
E
---
F
R
N
F
E
Y
V
S
P
---
50
Blastp_CBE
56.57
44%
-30
- C2 -
-
4DC2
3.8
-
KPCI_MOUSE
A:
[49-384]
----------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
---
K
K
---
T
-
D
----
R
I
Y
A
M
R
V
V
K
K
E
L
V
N
------
I
D
W
V
Q
T
E
K
H
V
F
E
Q
---
A
-
S
---
N
-
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
-
E
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
P
G
--
D
T
T
S
--
T
-
F
-
C
-
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
DIVGS---------------NTE
D
---
Y
L
F
Q
V
I
--
L
--
E
K
Q
I
--
R
I
P
-----
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
H
P
-
Q
T
G
F
A
D
-
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
--
P
-----
N
I
S
G
E
F
G
L
D
N
F
D
-
S
Q
F
T
N
E
P
V
Q
L
--
P
D
D
D
D
I
V
R
K
I
D
---
Q
S
E
---
F
E
G
F
E
Y
------
556
HHSearch
56.50
46%
-46
- C2 -
-
1XJD
7.8
-
A:
[16-335]
------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
D
F
I
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
F
---
K
K
---
T
-
N
----
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
--
M
D
D
D
V
E
C
T
M
V
E
K
R
V
L
-
S
L--
A
-
W
---
E
-
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
--
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
K
-
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
D
--
A
K
T
N
--
T
-
F
-
C
-
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
---
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
-
Q
S
P
F
-----
H
---
G
---
Q
----
D
E
---
E
---
E
L
F
H
S
I
--
R
--
M
D
N
P
--
F
Y
P
-----
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
G
V
-----
R
-
G
D
-
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
--------------------------------------------------
Q
N
M
---
F
R
N
F
S
F
------
95
Blastp_CBE
56.17
48%
-35
- C2 -
-
5F9E
7.8
-
B:
[16-340]
----------------------------------------------------------------------------------------------------------------------------------------------------
L
K
I
E
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
F
---
K
K
---
T
-
N
----
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
--
M
D
D
D
V
E
C
T
M
V
E
K
R
V
L
-
S
---
L
-
A
W--
E
-
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
--
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
D
--
A
K
T
N
--
E
-
F
-
C
-
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
---
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
-
Q
S
P
F
-----
H
---
G
---
Q
----
D
E
---
E
---
E
L
F
H
S
I
--
R
--
M
D
N
P
--
F
Y
P
-----
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
G
V
R
G
------
D
-
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
--
P
-----
K
V
K
S
P
F
--
S
N
F
D
---
F
L
N
E
--------------------------------------
525
Blastp_CBE
55.45
37%
-73
- C2 -
-
3QCX
6.9
-
PDPK1_HUMAN
A:
[34-309]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
------------N
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
---
A
---
G
----
N
E
---
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
-------------------------------------------------------------------
565
HHSearch
55.25
34%
-55
- C2 -
-
6ED6
7.9
-
ROCK2_HUMAN
A:
[85-413]
----------------------------------------------------------------------------------------------------------------------------------------------------
M
K
A
E
D
Y
D
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
H
---
K
A
---
S
-
Q
----
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
--
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
---
F
-
A
---
N
-
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
--
Y
-
D
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
-
G
L
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
H
G
H
L
K
L
A
D
F
G
T
C
M
K
M
D
E
T
G
M-
V
H
C
D
--
T
-
A
-
V
-
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
----F----
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
-
D
T
P
F
-----
Y
---
A
---
D
----
S
L
---
V
---
G
T
Y
S
K
I
--
M
--
D
H
K
N
SL
C
F
P
ED---
A
E
I
S
K
H
A
K
N
L
I
C
A
F
L
T
D
R
E
V
R
LG
R
N
------
G
V
-
E
E
-
I
R
Q
H
P
F
F
K
N
D
Q
---
W
H
W
D
N
I
R
E
T
A
A
P
V
V
--
P
-----
E
L
S
S
D
I
D
S
S
N
F
D
-
D
I
-------
E
T
F
P
I
P
-----
K
A
F
V
G
N
Q
L
P
---
F
I
G
F
T
Y
------
49
Blastp_CBE
55.22
49%
-42
- C2 -
-
3TXO
5.7
-
A:
[23-321]
-------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
F
E
F
I
R
V
L
G
K
G
-
S
F
G
K
V
M
L
A
R
V
---
K
E
---
T
-
G
----
D
L
Y
A
V
K
V
L
K
K
D
V
I
L
--
Q
D
D
D
V
E
C
T
M
T
E
K
R
I
L
-
S
---
L
-
A
---
R
N
H
P
F
L
T
Q
L
F
C
C
F
Q
T
P
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
--
S
R
R
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
-
D
K
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
H
E
G
H
C
K
L
A
D
F
G
M
C
K
E
G
I
---------------
C
-
G
T
P
D
Y
I
A
P
E
I
L
Q
E
M
---
L
-----
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
-
H
A
P
F
-----
E
---
A
---
E
----
N
E
---
D
---
D
L
F
E
A
I
--
L
--
N
D
E
V
--
V
Y
P
-----
T
W
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
--
R
L
G
S
L
T
-
Q
G
G
-
E
H
A
I
L
R
H
P
F
F
K
E
I
D
---
W
A
Q
L
N
H
R
Q
I
E
P
P
F
R
--
P
-----
R
I
K
S
R
E
D
V
S
N
F
D
-
P
D
F
I
K
E
--------------------------------------
522
Blastp_CBE
55.13
37%
-69
- C2 -
-
3QD3
9.0
-
PDPK1_HUMAN
A:
[34-309]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
------------N
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
---
A
---
G
----
N
E
---
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
-------------------------------------------------------------------
528
Blastp_CBE
55.03
37%
-70
- C2 -
-
3IOP
9.3
-
PDPK1_HUMAN
A:
[34-309]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
------------N
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
---
A
---
G
----
N
E
---
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
-------------------------------------------------------------------
533
Blastp_CBE
54.95
37%
-70
- C2 -
-
3RWP
8.4
-
PDPK1_HUMAN
A:
[33-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
------------N
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
---
A
---
G
----
N
E
---
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
-------------------------------------------------------------------
479
Blastp_CBE
54.85
37%
-69
- C2 -
-
3NUY
3.8
-
PDPK1_HUMAN
A:
[9-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
------------N
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
---
A
---
G
----
N
E
---
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
-------------------------------------------------------------------
481
Blastp_CBE
54.81
37%
-67
- C2 -
-
3NUS
3.6
-
PDPK1_HUMAN
A:
[9-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
------------N
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
---
A
---
G
----
N
E
---
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
-------------------------------------------------------------------
520
Blastp_CBE
54.80
37%
-68
- C2 -
-
3H9O
7.2
-
PDPK1_HUMAN
A:
[33-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
------------N
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
---
A
---
G
----
N
E
---
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
-------------------------------------------------------------------
535
Blastp_CBE
54.79
37%
-73
- C2 -
-
3NAY
7.6
-
PDPK1_HUMAN
A:
[30-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
-----------
A
N
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
---
A
---
G
----
N
E
---
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
-------------------------------------------------------------------
526
Blastp_CBE
54.78
37%
-69
- C2 -
-
3QCS
6.3
-
PDPK1_HUMAN
A:
[34-309]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
------------N
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
---
A
---
G
----
N
E
---
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
-------------------------------------------------------------------
509
Blastp_CBE
54.75
37%
-68
- C2 -
-
3NUN
5.4
-
PDPK1_HUMAN
A:
[15-290]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
------------N
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
---
A
---
G
----
N
E
---
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
-------------------------------------------------------------------
480
Blastp_CBE
54.71
37%
-68
- C2 -
-
3NUU
3.6
-
PDPK1_HUMAN
A:
[9-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
------------N
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
---
A
---
G
----
N
E
---
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
-------------------------------------------------------------------
527
Blastp_CBE
54.55
37%
-70
* C2 *
-
3QCQ
6.1
-
PDPK1_HUMAN
A:
[34-309]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
------------N
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
---
A
---
G
----
N
E
---
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
-------------------------------------------------------------------
72
Blastp_CBE
54.53
46%
4
- C2 -
-
4L43
7.7
-
KS6B1_HUMAN
A:
[10-344]
-----------------------------------------------------------------------------------------------------------------------------------------------
R
G
P
E
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
RN
A
K
D
-
T
A
H
T
K
A
E
R
N
I
L
-
E
---
E
-
V
---
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
------------------
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
---
G
---
E
----
N
R
---
K
---
K
T
I
D
K
I
--
L
--
K
C
K
L
--
N
L
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
G
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
--
P
-----
L
L
Q
S
E
E
D
V
S
Q
F
D
-
S
K
F
T
R
Q
----
T
P
V
----------
S
A
N
Q
V
----
F
L
G
F
A
Y
V
A
----
455
Blastp_CBE
54.43
38%
-32
- C2 -
-
2ACX
4.8
-
GRK6_HUMAN
B:
[178-535]
-------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
-
G
F
G
E
V
C
A
C
Q
V
---
R
A
---
T
-
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
K
--
K
R
K
G
E
A
M
A
L
N
E
K
Q
I
L
-
E
---
K
-
V
---
N
-
S
R
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M--
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
R
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
D
H
G
H
I
R
I
S
D
L
G
L
A
V
H
-
V
P
E
G
--
Q
T
I
K
--
G
-
R
-
V
-
G
T
V
G
Y
M
A
P
E
V
V
K
N
E
---
R
-----
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
-
Q
S
P
F
-----
Q
---
Q
-------------
K
---
I
K
R
E
E
V
ER
L
--
V
K
E
V
PE
E
Y
S
-----
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
--
R
L
G
C
R
G
-
G
S
A
-
R
E
-
V
K
E
H
P
L
F
K
K
L
N
---
F
K
R
L
G
A
G
M
L
E
P
P
F
K
PD
P
-----
Q
A
I
Y
C
K
D
V
L
D
I
E
-
Q
F
S
T
V
K
G
V
E
L
E
P
T
D
Q
D
----------------------------
531
Blastp_CBE
54.27
37%
-70
- C2 -
-
3SC1
4.7
-
PDPK1_HUMAN
A:
[33-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
-----------
A
N
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
---
A
---
G
----
N
E
---
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
-------------------------------------------------------------------
513
Blastp_CBE
54.27
37%
-71
- C2 -
-
1OKZ
8.7
-
PDPK1_HUMAN
A:
[31-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
------------N
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
---
A
---
G
----
N
E
---
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
-------------------------------------------------------------------
70
Blastp_CBE
54.24
47%
-28
- C2 -
-
4RA4
6.9
-
KPCA_HUMAN
A:
[16-349]
---------------------------------------------------------------------------------------------------------------------------------------------------
R
V
K
L
T
D
F
N
F
L
M
V
L
G
K
G
-
S
F
G
K
V
M
L
A
D
R
---
K
G
---
T
-
E
----
E
L
Y
A
I
K
I
L
K
K
D
V
V
I
--
Q
D
D
D
V
E
C
T
M
V
E
K
R
V
L
-
A
---
L
L
D
---
K
-
P
P
F
L
T
Q
L
H
S
C
F
Q
T
V
D
R
L
Y
F
V
M
E
Y
V
N
G
G
D
L
M
Y
H
I
Q
Q
--
V
G
K
F
K
E
P
Q
A
V
F
Y
A
A
E
I
S
I
G
L
F
F
L
H
-
K
R
G
I
I
Y
R
D
L
K
L
D
N
V
M
L
D
-
S
E
G
H
I
K
I
A
D
F
G
M
C
K
E
H
M
M
D
G
--
V
T
T
R
--
T
-
F
-
C
-
G
T
P
D
Y
I
A
P
E
I
I
A
Y
Q
---
P
-----
Y
G
K
S
V
D
W
W
A
Y
G
V
L
L
Y
E
M
L
A
G
-
Q
P
P
F
-----
D
---
G
---
E
----
D
E
---
D
---
E
L
F
Q
S
I
--
M
--
E
H
N
V
--
S
Y
P
-----
K
S
L
S
K
E
A
V
S
I
C
K
G
L
M
T
K
H
P
A
K
--
R
L
G
C
G
P
-
E
G
E
-
R
D
-
V
R
E
H
A
F
F
R
R
I
D
---
W
E
K
L
E
N
R
E
I
Q
P
P
F
K
--
P
-----
K
V
S
G
K
G
T
A
E
N
F
D
-
K
F
F
T
R
G
Q
-
P
V
L
P
P
D
Q
-----------------------------
514
Blastp_CBE
54.17
37%
-67
- C2 -
-
1OKY
8.4
-
PDPK1_HUMAN
A:
[31-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
P
E
S
---------N
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
---
A
---
G
----
N
E
---
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
-------------------------------------------------------------------
476
Blastp_CBE
54.05
37%
-68
- C2 -
-
1UU9
3.2
-
PDPK1_HUMAN
A:
[10-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
------------N
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
---
A
---
G
----
N
E
---
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
-------------------------------------------------------------------
492
Blastp_CBE
53.71
37%
-50
- C2 -
-
2BIY
5.4
-
PDPK1_HUMAN
A:
[31-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
P
E
S
KQ
A
R
A
N
--
A
-
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
---
A
---
G
----
N
E
---
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
-------------------------------------------------------------------
534
Blastp_CBE
53.62
37%
-73
- C2 -
-
3NAY
7.8
-
PDPK1_HUMAN
B:
[30-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
-----------
A
N
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
---
A
---
G
----
N
E
---
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
-------------------------------------------------------------------
468
Blastp_CBE
53.56
38%
-20
- C2 -
-
4UAL
6.5
-
MRCKB_HUMAN
A:
[77-419]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
E
I
I
K
V
I
G
R
G
-
A
F
G
E
V
A
V
V
K
M
---
K
N
---
T
-
E
----
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
--
K
R
A
E
T
A
C
F
R
E
E
R
D
V
L
-
V
---
N
-
G
---
D
-
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F-
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
-
Q
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
-
V
N
G
H
I
R
L
A
D
F
G
S
C
L
K
M
N
D
D
G
--
T
V
------
V
-
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
---
E
DGK--
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
-
E
T
P
F
-----
Y
---
A
---
E
----
S
L
---
V
---
E
T
Y
G
K
I
--
M
--
N
H
E
E
--
R
F
Q
FPSHV
T
D
V
S
E
E
A
K
D
L
I
Q
R
L
I
C
S
R
E
R
R
--
L
G
Q
N
G
I
-
E
D
F
-
K
----
K
H
A
F
F
E
G
L
N
---
W
E
N
I
--
R
N
L
E
A
P
Y
I
--
P
-----
D
V
S
S
P
S
D
T
S
N
F
D
V
D
D
D
V
L
R
N
T
E
I
L
P
P
-------------------------------
80
Blastp_CBE
53.55
47%
2
- C2 -
-
4L46
8.5
-
KS6B1_HUMAN
A:
[9-343]
----------------------------------------------------------------------------------------------------------------------------------------------
N
R
G
P
E
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
RN
A
K
D
-
T
A
H
T
K
A
E
R
N
I
L
-
E
---
E
-
V
---
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
------
H
--
T
-
F
-
C
-
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
---
G
---
E
----
N
R
---
K
---
K
T
I
D
K
I
--
L
--
K
C
K
L
--
N
L
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
G
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
--
P
-----
L
---
E
E
D
V
S
Q
F
D
-
S
K
F
T
R
Q
T
P
V
D
S
P
D
D
S
T
L
S
--------------------------
470
Blastp_CBE
53.53
38%
-19
- C2 -
-
3TKU
5.1
-
MRCKB_HUMAN
B:
[91-431]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
E
I
I
K
V
I
G
R
G
-
A
F
G
E
V
A
V
V
K
M
---
K
N
---
T
-
E
----
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
--
K
R
A
E
T
A
C
F
R
E
E
R
D
V
L
-
V
---
N
-
G
---
D
-
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F-
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
-
Q
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
-
V
N
G
H
I
R
L
A
D
F
G
S
C
L
K
M
N
D
D
G
--
T
V
Q
S
--
S
-
V
-
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
---
E
DGMGK
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
-
E
T
P
F
-----
Y
---
A
---
E
----
S
L
---
V
---
E
T
Y
G
K
I
--
M
--
N
H
E
E
--
R
F
Q
FPSHV
T
D
V
S
E
E
A
K
D
L
I
Q
R
L
I
C
S
R
E
R
R
--
L
G
Q
N
G
I
-
E
D
F
-
K
----
K
H
A
F
F
E
G
L
N
---
W
E
N
I
--
R
N
L
E
A
P
Y
I
--
P
-----
D
V
S
S
P
S
D
T
S
N
F
D
V
D
D
D
V
L
R
N
T
E
I
L
P
P
-------------------------------
510
Blastp_CBE
53.43
37%
-71
- C2 -
-
1UU8
3.1
-
PDPK1_HUMAN
A:
[31-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
-----------
A
N
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
---
A
---
G
----
N
E
---
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
-------------------------------------------------------------------
469
Blastp_CBE
53.41
38%
-21
- C2 -
-
4UAK
4.5
-
MRCKB_HUMAN
A:
[77-419]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
E
I
I
K
V
I
G
R
G
-
A
F
G
E
V
A
V
V
K
M
---
K
N
---
T
-
E
----
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
--
K
R
A
E
T
A
C
F
R
E
E
R
D
V
L
-
V
---
N
-
G
---
D
-
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F-
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
-
Q
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
-
V
N
G
H
I
R
L
A
D
F
G
S
C
L
K
M
N
D
D
G
--
T
V
Q
S
--
S
-
V
-
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
---
E
DGMGK
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
-
E
T
P
F
-----
Y
---
A
---
E
----
S
L
---
V
---
E
T
Y
G
K
I
--
M
--
N
H
E
E
--
R
F
Q
FPSHV
T
D
V
S
E
E
A
K
D
L
I
Q
R
L
I
C
S
R
E
R
R
--
L
G
Q
N
G
I
-
E
D
F
-
K
----
K
H
A
F
F
E
G
L
N
---
W
E
N
I
--
R
N
L
E
A
P
Y
I
--
P
-----
D
V
S
S
P
S
D
T
S
N
F
D
V
D
D
D
V
L
R
N
T
E
I
L
P
P
-------------------------------
471
Blastp_CBE
53.32
38%
-20
- C2 -
-
3TKU
4.9
-
MRCKB_HUMAN
A:
[91-431]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
E
I
I
K
V
I
G
R
G
-
A
F
G
E
V
A
V
V
K
M
---
K
N
---
T
-
E
----
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
--
K
R
A
E
T
A
C
F
R
E
E
R
D
V
L
-
V
---
N
-
G
---
D
-
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F-
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
-
Q
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
-
V
N
G
H
I
R
L
A
D
F
G
S
C
L
K
M
N
D
D
G
--
T
V
Q
S
--
S
-
V
-
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
---
E
DGMGK
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
-
E
T
P
F
-----
Y
---
A
---
E
----
S
L
---
V
---
E
T
Y
G
K
I
--
M
--
N
H
E
E
--
R
F
Q
FPSHV
T
D
V
S
E
E
A
K
D
L
I
Q
R
L
I
C
S
R
E
R
R
--
L
G
Q
N
G
I
-
E
D
F
-
K
----
K
H
A
F
F
E
G
L
N
---
W
E
N
I
--
R
N
L
E
A
P
Y
I
--
P
-----
D
V
S
S
P
S
D
T
S
N
F
D
V
D
D
D
V
L
R
N
T
E
I
L
P
P
-------------------------------
506
Blastp_CBE
53.24
37%
-65
- C2 -
-
2XCH
7.3
-
PDPK1_HUMAN
A:
[31-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
-----------
A
N
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
---
A
---
G
----
N
E
---
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
-------------------------------------------------------------------
466
Blastp_CBE
53.19
38%
-24
- C2 -
-
5OTF
6.4
-
MRCKB_HUMAN
A:
[77-419]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
E
I
I
K
V
I
G
R
G
-
A
F
G
E
V
A
V
V
K
M
---
K
N
---
T
-
E
----
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
--
K
R
A
E
T
A
C
F
R
E
E
R
D
V
L
-
V
---
N
-
G
---
D
-
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F-
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
-
Q
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
-
V
N
G
H
I
R
L
A
D
F
G
S
C
L
K
M
N
D
D
G
--
T
V
Q
S
--
S
-
V
-
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
---
E
DGMGK
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
-
E
T
P
F
-----
Y
---
A
---
E
----
S
L
---
V
---
E
T
Y
G
K
I
--
M
--
N
H
E
E
--
R
F
Q
FPSHV
T
D
V
S
E
E
A
K
D
L
I
Q
R
L
I
C
S
R
E
R
R
--
L
G
Q
N
G
I
-
E
D
F
-
K
----
K
H
A
F
F
E
G
L
N
---
W
E
N
I
--
R
N
L
E
A
P
Y
I
--
P
-----
D
V
S
S
P
S
D
T
S
N
F
D
V
D
D
D
V
L
R
N
T
E
I
L
P
P
-------------------------------
489
Blastp_CBE
53.17
37%
-60
- C2 -
-
3NAX
10.0
-
PDPK1_HUMAN
A:
[30-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
P
E
S
KQ
A
R
------------
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
---
A
---
G
----
N
E
---
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
-------------------------------------------------------------------
76
Blastp_CBE
53.09
46%
10
- C2 -
-
4L45
8.2
-
KS6B1_HUMAN
A:
[10-344]
-----------------------------------------------------------------------------------------------------------------------------------------------
R
G
P
E
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
RN
A
K
D
-
T
A
H
T
K
A
E
R
N
I
L
-
E
---
E
-
V
---
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
------------------
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
---
G
---
E
----
N
R
---
K
---
K
T
I
D
K
I
--
L
--
K
C
K
L
--
N
L
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
G
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
--
P
-----
L
L
Q
S
E
E
D
V
S
Q
F
D
-
S
K
F
T
R
Q
----
T
P
V
---------
E
S
A
N
Q
V
----
F
L
G
F
E
Y
V
A
----
465
Blastp_CBE
53.05
38%
-18
- C2 -
-
3QFV
3.3
-
MRCKB_HUMAN
A:
[75-415]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
E
I
I
K
V
I
G
R
G
-
A
F
G
E
V
A
V
V
K
M
---
K
N
---
T
-
E
----
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
--
K
R
A
E
T
A
C
F
R
E
E
R
D
V
L
-
V
---
N
-
G
---
D
-
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F-
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
-
Q
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
-
V
N
G
H
I
R
L
A
D
F
G
S
C
L
K
M
N
D
D
G
--
T
V
Q
S
--
S
-
V
-
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
---
E
DGMGK
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
-
E
T
P
F
-----
Y
---
A
---
E
----
S
L
---
V
---
E
T
Y
G
K
I
--
M
--
N
H
E
E
--
R
F
Q
FPSHV
T
D
V
S
E
E
A
K
D
L
I
Q
R
L
I
C
S
R
E
R
R
--
L
G
Q
N
G
I
-
E
D
F
-
K
----
K
H
A
F
F
E
G
L
N
---
W
E
N
I
--
R
N
L
E
A
P
Y
I
--
P
-----
D
V
S
S
P
S
D
T
S
N
F
D
V
D
D
D
V
L
R
N
T
E
I
L
P
P
-------------------------------
464
Blastp_CBE
52.85
38%
-18
- C2 -
-
3QFV
4.1
-
MRCKB_HUMAN
B:
[75-415]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
E
I
I
K
V
I
G
R
G
-
A
F
G
E
V
A
V
V
K
M
---
K
N
---
T
-
E
----
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
--
K
R
A
E
T
A
C
F
R
E
E
R
D
V
L
-
V
---
N
-
G
---
D
-
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F-
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
-
Q
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
-
V
N
G
H
I
R
L
A
D
F
G
S
C
L
K
M
N
D
D
G
--
T
V
Q
S
--
S
-
V
-
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
---
E
DGMGK
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
-
E
T
P
F
-----
Y
---
A
---
E
----
S
L
---
V
---
E
T
Y
G
K
I
--
M
--
N
H
E
E
--
R
F
Q
FPSHV
T
D
V
S
E
E
A
K
D
L
I
Q
R
L
I
C
S
R
E
R
R
--
L
G
Q
N
G
I
-
E
D
F
-
K
----
K
H
A
F
F
E
G
L
N
---
W
E
N
I
--
R
N
L
E
A
P
Y
I
--
P
-----
D
V
S
S
P
S
D
T
S
N
F
D
V
D
D
D
V
L
R
N
T
E
I
L
P
P
-------------------------------
502
Blastp_CBE
52.71
37%
-104
- C2 -
-
5HO8
6.4
-
PDPK1_HUMAN
A:
[31-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
------------N
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
---
A
---
G
----
N
E
---
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
-------------------------------------------------------------------
467
Blastp_CBE
52.66
38%
-18
- C2 -
-
5OTE
6.1
-
MRCKB_HUMAN
A:
[77-419]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
E
I
I
K
V
I
G
R
G
-
A
F
G
E
V
A
V
V
K
M
---
K
N
---
T
-
E
----
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
--
K
R
A
E
T
A
C
F
R
E
E
R
D
V
L
-
V
---
N
-
G
---
D
-
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F-
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
-
Q
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
-
V
N
G
H
I
R
L
A
D
F
G
S
C
L
K
M
N
D
D
G
--
T
V
Q
S
--
S
-
V
-
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
---
E
DGK--
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
-
E
T
P
F
-----
Y
---
A
---
E
----
S
L
---
V
---
E
T
Y
G
K
I
--
M
--
N
H
E
E
--
R
F
Q
FPSHV
T
D
V
S
E
E
A
K
D
L
I
Q
R
L
I
C
S
R
E
R
R
--
L
G
Q
N
G
I
-
E
D
F
-
K
----
K
H
A
F
F
E
G
L
N
---
W
E
N
I
--
R
N
L
E
A
P
Y
I
--
P
-----
D
V
S
S
P
S
D
T
S
N
F
D
V
D
D
D
V
L
R
N
T
E
I
L
P
P
-------------------------------
503
Blastp_CBE
52.41
37%
-106
- C2 -
-
5HO7
3.5
-
PDPK1_HUMAN
A:
[31-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
P
-----------N
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
---
A
---
G
----
N
E
---
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
-------------------------------------------------------------------
71
Blastp_CBE
52.00
46%
14
- C2 -
-
4L44
7.8
-
KS6B1_HUMAN
A:
[10-344]
-----------------------------------------------------------------------------------------------------------------------------------------------
R
G
P
E
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
RN
A
K
D
-
T
A
H
T
K
A
E
R
N
I
L
-
E
---
E
-
V
---
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
-------
H
--
T
-
F
-
C
-
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
---
G
---
E
----
N
R
---
K
---
K
T
I
D
K
I
--
L
--
K
C
K
L
--
N
L
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
G
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
--
P
-----
L
L
Q
S
E
E
D
V
S
Q
-
D
-
S
K
F
T
R
Q
----
T
----------
S
E
S
A
N
Q
V
----
F
L
G
F
A
Y
V
A
----
458
Blastp_CBE
51.98
38%
-14
- C2 -
-
3NYO
4.7
-
GRK6_HUMAN
A:
[178-497]
-------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
-
G
F
G
E
V
C
A
C
Q
V
---
R
A
---
T
-
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
K
--
K
R
K
G
E
A
M
A
L
N
E
K
Q
I
L
-
E
---
K
-
V
---
N
-
S
R
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
MG
Q
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
R
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
D
H
G
H
I
R
I
S
D
L
G
L
A
V
H
-
V
P
E
G
--
Q
T
I
K
--
G
-
R
-
V
-
G
T
V
G
Y
M
A
P
E
V
V
K
N
E
---
R
-----
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
-
Q
S
P
F
-----
Q
-------------
K
---
K
---
I
K
R
E
E
V
ER
L
--
V
K
E
V
PE
E
Y
S
-----
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
--
R
L
G
C
R
G
-
G
S
A
-
R
E
-
V
K
E
H
P
L
F
K
K
L
N
---
F
K
R
L
G
A
G
M
L
E
P
P
F
K
PD
P
-----
Q
A
I
Y
C
K
D
V
L
D
I
E
-
Q
F
S
T
V
K
G
V
E
L
E
P
T
D
Q
D
----------------------------
566
HHSearch
51.97
46%
13
- C2 -
-
4L44
7.8
-
KS6B1_HUMAN
A:
[14-346]
---------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
---
V
T
GAN
T
-
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R-
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
-
E
---
E
-
V
---
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
-------
H
--
T
-
F
-
C
-
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
---
G
---
E
----
N
R
---
K
---
K
T
I
D
K
I
--
L
--
K
C
K
L
--
N
L
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
G
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
--
P
-----
L
L
Q
S
E
E
D
V
S
Q
-
D
-
S
K
F
T
R
Q
T
---------------
S
E
S
A
N
Q
V
---
F
L
G
F
A
Y
V
A
P
S
--
504
Blastp_CBE
51.73
37%
-107
- C2 -
-
5HNG
4.5
-
PDPK1_HUMAN
A:
[31-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
P
-----------N
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
---
A
---
G
----
N
E
---
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
-------------------------------------------------------------------
456
Blastp_CBE
51.71
38%
-12
- C2 -
-
2ACX
5.2
-
GRK6_HUMAN
A:
[178-532]
-------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
-
G
F
G
E
V
C
A
C
Q
V
---
R
A
---
T
-
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
K
--
K
R
K
G
E
A
M
A
L
N
E
K
Q
I
L
-
E
---
K
-
V
---
N
-
S
R
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
MG
Q
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
R
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
D
H
G
H
I
R
I
S
D
L
G
L
A
V
H
-
V
P
E
G
--
Q
T
I
K
--
G
-
R
-
V
-
G
T
V
G
Y
M
A
P
E
V
V
K
N
E
---
R
-----
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
-
Q
S
P
F
-----
Q
---
Q
---
R
----
K
K
---
K
---
I
K
R
E
E
V
ER
L
--
V
K
E
V
PE
E
Y
S
-----
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
--
R
L
G
C
R
G
-
G
S
A
-
R
E
-
V
K
E
H
P
L
F
K
K
L
N
---
F
K
R
L
G
A
G
M
L
E
P
P
F
K
PD
P
-----
Q
A
I
Y
C
K
D
V
L
D
I
E
-
Q
F
S
T
V
K
G
V
E
L
E
P
T
D
Q
D
----------------------------
561
HHSearch
51.58
46%
-4
- C2 -
-
4OTH
7.4
-
A:
[7-339]
--------------------------------------------------------------------------------------------------------------------------------------------------
S
P
L
T
L
E
D
F
K
F
L
A
V
L
G
R
G
-
H
F
G
K
V
L
L
S
E
F
---
R
P
---
S
-
G
----
E
L
F
A
I
K
A
L
K
K
G
D
I
V
--
A
R
D
E
V
E
S
L
M
C
E
K
R
I
L
-
A
---
A
-
V
TSA
G
-
H
P
F
L
V
N
L
F
G
C
F
Q
T
P
E
H
V
C
F
V
M
E
Y
S
A
G
G
D
L
M
L
H
I
H
S
---
D
V
F
S
E
P
R
A
I
F
Y
S
A
C
V
V
L
G
L
Q
F
L
H
E
H
-
K
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
-
T
E
G
Y
V
K
I
A
D
F
G
L
C
K
--------------------------------------------
T
R
A
V
D
W
W
G
L
G
V
L
L
Y
E
M
L
V
G
-
E
S
P
F
-----
P
---
G
---
D
----
D
E
---
E
---
E
V
F
D
S
I
--
V
--
N
D
E
V
--
R
Y
P
-----
R
F
L
S
A
E
A
I
G
I
M
R
R
L
L
R
R
N
P
E
R
--
R
L
G
S
S
E
-
R
D
A
-
E
D
-
V
K
K
Q
P
F
F
R
T
L
G
---
W
E
A
L
L
A
R
R
L
P
P
P
F
V
--
P
-----
T
L
S
G
R
T
D
V
S
N
F
D
-
E
E
F
T
G
E
A
P
T
L
S
P
P
R
D
A
---
R
P
L
T
A
A
E
Q
A
A
---
F
L
D
F
D
F
V
A
G
---
446
Blastp_CBE
51.43
37%
-91
- C2 -
-
5LOH
8.1
-
GWL_HUMAN
B:
[33-316]
----------------------------------------------------------------------------------------------------------------------------------------------------
P
S
I
E
E
F
S
I
V
K
P
I
S
R
G
-
A
F
G
K
V
Y
L
G
Q
K
---
G
------
G
----
K
L
Y
A
V
K
V
V
K
K
A
D
M
I
--
N
K
--------------
A
---
L
-
S
---
K
-
S
P
F
I
V
H
L
Y
Y
S
L
Q
S
A
N
N
V
Y
L
V
M
E
Y
L
I
G
G
D
V
K
S
L
L
H
I
--
Y
G
Y
F
D
E
E
M
A
V
K
Y
I
S
E
V
A
L
A
L
D
Y
L
H
-
R
H
G
I
I
H
R
D
L
K
P
D
N
M
L
I
S
-
N
E
G
H
I
K
L
T
D
F
G
L
----------------------
G
T
P
D
Y
L
A
P
E
L
L
L
G
R
---
A
-----
H
G
P
A
V
D
W
W
A
L
G
V
C
L
F
E
F
L
T
G
-
I
P
P
F
-----
N
---
D
---
E
----
T
P
---
Q
---
Q
V
F
Q
N
I
--
L
--
K
R
D
I
--
P
W
P
EGE--
E
K
L
S
D
N
A
Q
S
A
V
E
I
L
L
T
I
D
D
T
K
--
R
A
G
------
M
-
K
E
-
L
K
R
H
P
L
F
S
D
V
D
---
W
E
N
L
Q
H
Q
T
M
--
P
F
I
--
P
-----
Q
P
-------------------------------------------------------
75
Blastp_CBE
51.34
46%
-3
- C2 -
-
4L42
7.6
-
KS6B1_HUMAN
A:
[13-344]
--------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
RN
A
K
D
-
T
A
H
T
K
A
E
R
N
I
L
-
E
---
E
-
V
---
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
--
T
V
T
H
--
T
-
F
-
C
-
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
---
G
---
E
----
N
R
---
K
---
K
T
I
D
K
I
--
L
--
K
C
K
L
--
N
L
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
G
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
------------------------------------------------
E
M
---
F
R
D
F
E
Y
I
A
----
97
Blastp_CBE
51.23
45%
-1
- C2 -
-
4OTI
6.0
-
A:
[6-339]
-------------------------------------------------------------------------------------------------------------------------------------------------
K
S
P
L
T
L
E
D
F
K
F
L
A
V
L
G
R
G
-
H
F
G
K
V
L
L
S
E
F
---
R
P
---
S
-
G
----
E
L
F
A
I
K
A
L
K
K
G
D
I
V
--
A
R
D
E
V
E
S
L
M
C
E
K
R
I
L
-
A
AVT
S
-
A
---
G
-
H
P
F
L
V
N
L
F
G
C
F
Q
T
P
E
H
V
C
F
V
M
E
Y
S
A
G
G
D
L
M
L
H
I
H
S
--
D
-
V
F
S
E
P
R
A
I
F
Y
S
A
C
V
V
L
G
L
Q
F
L
H
-
E
H
K
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
-
T
E
G
Y
V
K
I
A
D
F
G
L
----------------------------------------------
T
R
A
V
D
W
W
G
L
G
V
L
L
Y
E
M
L
V
G
-
E
S
P
F
-----
P
---
G
---
D
----
D
E
---
E
---
E
V
F
D
S
I
--
V
--
N
D
E
V
--
R
Y
P
-----
R
F
L
S
A
E
A
I
G
I
M
R
R
L
L
R
R
N
P
E
R
--
R
L
G
S
S
E
-
R
D
A
-
E
D
-
V
K
K
Q
P
F
F
R
T
L
G
---
W
E
A
L
L
A
R
R
L
P
P
P
F
V
--
P
-----
T
L
S
G
R
T
D
V
S
N
F
D
-
E
E
F
T
G
E
A
P
T
L
P
P
R
D
A
R
P
----
L
T
A
A
E
Q
A
A
---
F
L
D
F
D
F
V
A
G
G
--
462
Blastp_CBE
51.14
41%
-14
- C2 -
-
4TND
4.2
-
GRK5_HUMAN
A:
[181-467]
----------------------------------------------------------------------------------------------------------------------------------------------------
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
-
G
F
G
E
V
C
A
C
Q
V
---
R
A
---
T
-
G
----
K
M
Y
A
C
K
R
L
E
K
K
R
I
K
--
K
R
K
G
E
S
M
A
L
N
E
K
Q
I
L
-
E
---
K
-
V
---
N
-
S
Q
F
V
V
N
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
F
H
I
Y
N
MG
N
P
G
F
E
E
E
R
A
L
F
Y
A
A
E
I
L
C
G
L
E
D
L
H
H
E
-
N
T
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
D
Y
G
H
I
R
I
S
D
L
G
L
A
V
K
-
I
P
E
G
--
D
L
I
R
--
G
-
R
-
V
-
G
T
V
G
Y
M
A
P
E
V
L
N
N
Q
---
R
-----
Y
G
L
S
P
D
Y
W
G
L
G
C
L
I
Y
E
M
I
E
G
-
Q
S
P
F
-----
R
---
G
---
R
KEKV
K
R
---
E
---
E
V
D
R
R
V
--
L
--
E
T
E
E
--
V
Y
S
-----
H
K
F
S
E
E
A
K
S
I
C
K
M
L
L
T
K
D
A
K
Q
--
R
L
G
C
Q
E
-
E
E
A
-
A
E
-
V
K
R
H
P
F
F
R
N
M
N
---
F
K
R
L
E
A
G
M
L
D
P
P
F
V
--
P
--------------------------------------------------------------
457
Blastp_CBE
50.87
38%
-10
- C2 -
-
3NYO
4.7
-
GRK6_HUMAN
B:
[178-497]
-------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
-
G
F
G
E
V
C
A
C
Q
V
---
R
A
---
T
-
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
K
--
K
R
K
G
E
A
M
A
L
N
E
K
Q
I
L
-
E
---
K
-
V
---
N
-
S
R
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
MG
Q
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
R
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
D
H
G
H
I
R
I
S
D
L
G
L
A
V
H
-
V
P
E
G
--
Q
T
I
K
--
G
-
R
-
V
-
G
T
V
G
Y
M
A
P
E
V
V
K
N
E
---
R
-----
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
-
Q
S
P
F
-----
Q
-------------
K
---
K
---
I
K
R
E
E
V
ER
L
--
V
K
E
V
PE
E
Y
S
-----
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
--
R
L
G
C
R
G
-
G
S
A
-
R
E
-
V
K
E
H
P
L
F
K
K
L
N
---
F
K
R
L
G
A
G
M
L
E
P
P
F
K
PD
P
-----
Q
A
I
Y
C
K
D
V
L
D
I
E
-
Q
F
S
T
V
K
G
V
E
L
E
P
T
D
Q
D
----------------------------
105
Blastp_CBE
50.73
47%
-0
- C2 -
-
4L3J
7.9
-
KS6B1_HUMAN
A:
[14-304]
---------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
RN
A
K
D
-
T
A
H
T
K
A
E
R
N
I
L
-
E
---
E
-
V
---
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
--
T
V
T
H
--
T
-
F
-
C
-
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
---
G
---
E
----
N
R
---
K
---
K
T
I
D
K
I
--
L
--
K
C
K
L
--
N
L
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
G
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
--
P
-----
L
L
Q
S
-----------------------------------------------------
104
Blastp_CBE
50.68
47%
-2
- C2 -
-
4L3L
7.9
-
KS6B1_HUMAN
A:
[14-304]
---------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
RN
A
K
D
-
T
A
H
T
K
A
E
R
N
I
L
-
E
---
E
-
V
---
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
--
T
V
T
H
--
T
-
F
-
C
-
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
---
G
---
E
----
N
R
---
K
---
K
T
I
D
K
I
--
L
--
K
C
K
L
--
N
L
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
G
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
--
P
-----
L
L
Q
S
-----------------------------------------------------
98
Blastp_CBE
50.62
45%
2
- C2 -
-
4OTH
7.4
-
A:
[6-339]
-------------------------------------------------------------------------------------------------------------------------------------------------
K
S
P
L
T
L
E
D
F
K
F
L
A
V
L
G
R
G
-
H
F
G
K
V
L
L
S
E
F
---
R
P
---
S
-
G
----
E
L
F
A
I
K
A
L
K
K
G
D
I
V
--
A
R
D
E
V
E
S
L
M
C
E
K
R
I
L
-
A
AVT
S
-
A
---
G
-
H
P
F
L
V
N
L
F
G
C
F
Q
T
P
E
H
V
C
F
V
M
E
Y
S
A
G
G
D
L
M
L
H
I
H
S
--
D
-
V
F
S
E
P
R
A
I
F
Y
S
A
C
V
V
L
G
L
Q
F
L
H
-
E
H
K
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
-
T
E
G
Y
V
K
I
A
D
F
G
L
C
K
--------------------------------------------
T
R
A
V
D
W
W
G
L
G
V
L
L
Y
E
M
L
V
G
-
E
S
P
F
-----
P
---
G
---
D
----
D
E
---
E
---
E
V
F
D
S
I
--
V
--
N
D
E
V
--
R
Y
P
-----
R
F
L
S
A
E
A
I
G
I
M
R
R
L
L
R
R
N
P
E
R
--
R
L
G
S
S
E
-
R
D
A
-
E
D
-
V
K
K
Q
P
F
F
R
T
L
G
---
W
E
A
L
L
A
R
R
L
P
P
P
F
V
--
P
-----
T
L
S
G
R
T
D
V
S
N
F
D
-
E
E
F
T
G
E
A
P
T
L
P
P
R
D
A
R
P
----
L
T
A
A
E
Q
A
A
---
F
L
D
F
D
F
V
A
G
G
--
463
Blastp_CBE
50.44
41%
-11
- C2 -
-
4TNB
4.8
-
GRK5_HUMAN
A:
[181-467]
----------------------------------------------------------------------------------------------------------------------------------------------------
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
-
G
F
G
E
V
C
A
C
Q
V
---
R
A
---
T
-
G
----
K
M
Y
A
C
K
R
L
E
K
K
R
I
K
--
K
R
K
G
E
S
M
A
L
N
E
K
Q
I
L
-
E
---
K
-
V
---
N
-
S
Q
F
V
V
N
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
F
H
I
Y
N
MG
N
P
G
F
E
E
E
R
A
L
F
Y
A
A
E
I
L
C
G
L
E
D
L
H
H
E
-
N
T
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
D
Y
G
H
I
R
I
S
D
L
G
L
A
V
K
-
I
P
E
G
--
D
L
I
R
--
G
-
R
-
V
-
G
T
V
G
Y
M
A
P
E
V
L
N
N
Q
---
R
-----
Y
G
L
S
P
D
Y
W
G
L
G
C
L
I
Y
E
M
I
E
G
-
Q
S
P
F
-----
R
---
G
---
R
KEKV
K
R
---
E
---
E
V
D
R
R
V
--
L
--
E
T
E
E
--
V
Y
S
-----
H
K
F
S
E
E
A
K
S
I
C
K
M
L
L
T
K
D
A
K
Q
--
R
L
G
C
Q
E
-
E
E
A
-
A
E
-
V
K
R
H
P
F
F
R
N
M
N
---
F
K
R
L
E
A
G
M
L
D
P
P
F
V
--
P
--------------------------------------------------------------
472
Blastp_CBE
49.72
36%
11
- C2 -
-
5UVC
7.0
-
ARBK1_HUMAN
A:
[195-543]
----------------------------------------------------------------------------------------------------------------------------------------------------
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
-
G
F
G
E
V
Y
G
C
R
K
---
A
D
---
T
-
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
K
--
M
K
Q
G
E
T
L
A
L
N
E
R
I
M
L
-
S
LVS
T
-
G
---
D
-
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
--
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
-
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
F
S
K
K
K
--
P
H
A
S
--
V
-----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V--
A
-----
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
-
H
S
P
F
-----
R
QHK
T
---
K
----
D
K
---
H
---
E
I
D
R
M
T
--
L
--
T
M
A
V
--
E
L
P
-----
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
--
R
L
G
C
L
G
-
R
G
A
-
Q
E
-
V
K
E
S
P
F
F
R
S
L
D
---
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
--
P
PRGEV
N
A
A
D
A
F
D
I
G
S
F
D
-
E
E
D
T
-
K
G
I
K
L
L
D
S
D
Q
E
----------------------------
99
Blastp_CBE
49.64
45%
-15
- C2 -
-
4OTG
8.5
-
A:
[6-339]
-------------------------------------------------------------------------------------------------------------------------------------------------
K
S
P
L
T
L
E
D
F
K
F
L
A
V
L
G
R
G
-
H
F
G
K
V
L
L
S
E
F
---
R
P
---
S
-
G
----
E
L
F
A
I
K
A
L
K
K
G
D
I
V
--
A
R
D
E
V
E
S
L
M
C
E
K
R
I
L
-
A
AVT
S
-
A
---
G
-
H
P
F
L
V
N
L
F
G
C
F
Q
T
P
E
H
V
C
F
V
M
E
Y
S
A
G
G
D
L
M
L
H
I
H
S
--
D
-
V
F
S
E
P
R
A
I
F
Y
S
A
C
V
V
L
G
L
Q
F
L
H
-
E
H
K
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
-
T
E
G
Y
V
K
I
A
D
F
G
L
C
K
E
G
M
G
Y
G
---
D
R
T
--
S
-
F
-
C
-
G
T
P
E
F
L
A
P
E
V
L
T
D
T
---
S
-----
Y
T
R
A
V
D
W
W
G
L
G
V
L
L
Y
E
M
L
V
G
-
E
S
P
F
-----
P
---
G
---
D
----
D
E
---
E
---
E
V
F
D
S
I
--
V
--
N
D
E
V
--
R
Y
P
-----
R
F
L
S
A
E
A
I
G
I
M
R
R
L
L
R
R
N
P
E
R
--
R
L
G
S
S
E
-
R
D
A
-
E
D
-
V
K
K
Q
P
F
F
R
T
L
G
---
W
E
A
L
L
A
R
R
L
P
P
P
F
V
--
P
-----
T
L
S
-------------
T
G
E
A
P
T
L
P
P
R
D
A
R
P
----
L
T
A
A
E
Q
A
A
---
F
L
D
F
D
F
V
A
G
G
C
-
65
Blastp_CBE
49.64
46%
-24
- C2 -
-
5LI9
6.6
-
KPCI_HUMAN
A:
[3-329]
----------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
---
K
K
---
T
-
D
----
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
--
D
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
---
A
-
S
---
N
-
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
-
E
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
P
G
--
D
T
-
T
--
S
-
F
-
C
-
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
D-------------------E--
D
---
Y
L
F
Q
V
I
--
L
--
E
K
Q
I
--
R
I
P
-----
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
H
P
-
Q
T
G
F
A
D
-
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
--
P
-----
N
I
S
G
E
F
G
L
D
N
F
D
-
S
Q
F
T
N
E
P
V
Q
L
--
P
D
D
D
D
I
V
R
K
I
D
---------------------
505
Blastp_CBE
49.37
37%
-80
- C2 -
-
5HKM
7.3
-
PDPK1_HUMAN
A:
[31-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
-------------
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
---
A
---
G
----
N
E
---
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
-------------------------------------------------------------------
54
Blastp_CBE
49.35
45%
-26
- C2 -
-
3ZH8
7.2
-
KPCI_HUMAN
A:
[2-337]
----------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
---
K
K
---
T
-
D
----
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
--
D
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
---
A
-
S
---
N
-
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
-
E
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
P
G
--
D
T
-
T
--
S
-
F
-
C
-
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
DIVG----------------TE-
D
---
Y
L
F
Q
V
I
--
L
--
E
K
Q
I
--
R
I
P
-----
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
H
P
-
Q
T
G
F
A
D
-
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
--
P
-----
N
I
S
G
E
F
---------
F
T
N
--------
D
D
D
D
I
V
R
K
I
D
---
Q
S
E
---
F
E
G
F
E
Y
------
53
Blastp_CBE
49.34
45%
-28
- C2 -
-
3ZH8
6.7
-
KPCI_HUMAN
B:
[2-337]
----------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
---
K
K
---
T
-
D
----
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
--
D
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
---
A
-
S
---
N
-
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
-
E
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
P
G
--
D
T
-
T
--
S
-
F
-
C
-
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
DIVG----------------TE-
D
---
Y
L
F
Q
V
I
--
L
--
E
K
Q
I
--
R
I
P
-----
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
H
P
-
Q
T
G
F
A
D
-
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
--
P
-----
N
I
S
G
E
F
---------
F
T
N
--------
D
D
D
D
I
V
R
K
I
D
---
Q
S
E
---
F
E
G
F
E
Y
------
61
Blastp_CBE
49.06
46%
-23
- C2 -
-
3A8W
6.7
-
KPCI_HUMAN
B:
[6-332]
----------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
---
K
K
---
T
-
D
----
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
--
D
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
---
A
-
S
---
N
-
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
-
E
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
---
G
--
D
T
-
T
--
S
-
F
-
C
-
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
DI------------------E--
D
---
Y
L
F
Q
V
I
--
L
--
E
K
Q
I
--
R
I
P
-----
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
H
P
-
Q
T
G
F
A
D
-
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
--
P
-----
N
I
S
G
E
F
G
L
D
N
F
D
-
S
Q
F
T
N
E
P
V
Q
L
--
P
D
D
D
D
I
V
R
K
I
D
---------------------
85
Blastp_CBE
48.92
48%
-4
- C2 -
-
3WF7
8.1
-
KS6B1_HUMAN
A:
[21-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
RN
A
K
D
-
T
A
H
T
K
A
E
R
N
I
L
-
E
---
E
-
V
---
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
-----
V
T
--
H
-
F
-
C
-
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
---
G
---
E
----
N
R
---
K
---
K
T
I
D
K
I
--
L
--
K
C
K
L
--
N
L
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
G
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
--
P
-----
L
L
Q
------------------------------------------------------
52
Blastp_CBE
48.78
45%
-25
- C2 -
-
3ZH8
3.3
-
KPCI_HUMAN
C:
[2-337]
----------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
---
K
K
---
T
-
D
----
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
--
D
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
---
A
-
S
---
N
-
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
-
E
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
P
G
--
D
T
-
T
--
S
-
F
-
C
-
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
DIVG----------------TE-
D
---
Y
L
F
Q
V
I
--
L
--
E
K
Q
I
--
R
I
P
-----
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
H
P
-
Q
T
G
F
A
D
-
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
--
P
-----
N
I
-------------
F
T
N
--------
D
D
D
D
I
V
R
K
I
D
---
Q
S
E
---
F
E
G
F
E
Y
------
453
Blastp_CBE
48.76
39%
-17
- C2 -
-
6BDL
3.1
-
B:
[30-326]
---------------------------------------------------------------------------------------------------------------------------------------------------
N
L
K
L
S
D
F
N
I
I
D
T
L
G
V
G
-
G
F
G
R
V
E
L
V
Q
L
---
K
S
---
E
E
S
----
K
T
F
A
M
K
I
L
K
K
R
H
I
V
--
D
T
R
Q
Q
E
H
I
R
S
E
K
Q
I
M
-
Q
---
G
-
A
---
H
-
S
D
F
I
V
R
L
Y
R
T
F
K
D
S
K
Y
L
Y
M
L
M
E
A
C
L
G
G
E
L
W
T
I
L
R
D
--
R
G
S
F
E
D
S
T
T
R
F
Y
T
A
C
V
V
E
A
F
A
Y
L
H
S
-
K
G
I
I
Y
R
D
L
K
P
E
N
L
I
L
D
-
H
R
G
Y
A
K
L
V
D
F
G
F
A
K
---
K
I
G
--
F
G
K
K
--
T
W
F
-
C
-
G
T
P
E
Y
V
A
P
E
I
I
L
N
K
---
G
-----
H
D
I
S
A
D
Y
W
S
L
G
I
L
M
Y
E
L
L
T
G
-
S
P
P
F
-----
S
---
G
---
P
----
D
P
---
M
---
K
T
Y
N
I
I
--
L
RG
I
D
M
I
--
E
F
P
-----
K
K
I
A
K
N
A
A
N
L
I
K
K
L
C
R
D
N
P
S
E
--
R
L
G
N
L
K
-
N
G
V
-
K
D
-
I
Q
K
H
K
W
F
E
G
F
N
---
W
E
G
L
R
K
G
T
L
T
P
P
I
I
--
P
-----
S
V
A
S
P
T
D
T
S
N
F
D
---------------------------------------------
495
Blastp_CBE
48.71
36%
15
- C2 -
-
6C2Y
8.2
-
ARBK1_HUMAN
A:
[186-639]
----------------------------------------------------------------------------------------------------------------------------------------------------
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
-
G
F
G
E
V
Y
G
C
R
K
---
A
D
---
T
-
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
K
--
M
K
Q
G
E
T
L
A
L
N
E
R
I
M
L
-
S
LVS
T
-
G
---
D
-
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
--
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
-
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
F
S
K
K
K
--
P
H
A
S
--
V
-----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V--
A
-----
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
-
H
S
P
F
-----
R
---
Q
HKT
K
----
D
K
---
H
---
E
I
D
R
M
T
--
L
----
A
V
--
E
L
P
-----
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
--
R
L
G
C
L
G
-
R
G
A
-
Q
E
-
V
K
E
S
P
F
F
R
S
L
D
---
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
--
P
PRGEV
N
A
A
D
A
F
D
I
G
S
F
D
-
E
E
D
T
-
K
G
I
K
L
L
D
S
D
Q
E
----------------------------
112
Blastp_CBE
48.69
45%
-12
- C2 -
-
4CRS
5.5
-
A:
[1-338]
--------------------------------------------------------------------------------------------------------------------------------------------
S
M
S
Q
Q
R
F
Q
F
N
L
Q
D
F
R
C
C
A
V
L
L
R
G
-
H
F
G
K
V
L
L
A
E
Y
---
K
N
---
T
-
N
----
E
M
F
A
I
K
A
L
K
K
G
D
I
V
--
A
R
D
E
V
D
S
L
M
C
E
K
R
I
F
-
E
TVN
S
-
V
---
R
-
H
P
F
L
V
N
L
F
A
C
F
Q
T
K
E
H
V
C
F
V
M
E
Y
A
A
G
G
D
L
M
M
H
I
H
T
--
D
-
V
F
S
E
P
R
A
V
F
Y
A
A
C
V
V
L
G
L
Q
Y
L
H
E
H
K
-
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
-
T
E
G
F
V
K
I
A
D
F
G
L
C
K
E
G
M
G
Y
G
---
D
R
T
--
S
-
F
-
C
-
G
T
P
E
F
L
A
P
E
V
L
T
E
T
---
S
-----
Y
T
R
A
V
D
W
W
G
L
G
V
L
I
Y
E
M
L
V
G
-
E
S
P
F
-----
P
---
G
---
D
----
D
E
---
E
---
E
V
F
D
S
I
--
V
--
N
D
E
V
--
R
Y
P
-----
R
F
L
S
T
E
A
I
S
I
M
R
R
L
L
R
R
N
P
E
R
--
R
L
G
A
S
E
-
K
D
A
-
E
D
-
V
K
K
H
P
F
F
R
L
I
D
---
W
S
A
L
M
D
K
K
V
K
P
P
F
I
--
P
-----
T
I
R
G
R
E
D
V
S
N
F
D
-
D
E
F
T
S
E
A
-
P
I
L
P
P
R
E
P
---
R
I
L
----------
F
R
D
F
D
Y
I
A
----
62
Blastp_CBE
48.69
46%
-25
- C2 -
-
3A8W
7.3
-
KPCI_HUMAN
A:
[6-332]
----------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
---
K
K
---
T
-
D
----
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
------
I
D
W
V
Q
T
E
K
H
V
F
E
Q
---
A
-
S
---
N
-
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
-
E
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
P
G
--
D
T
-
T
--
S
-
F
-
C
-
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
DI------------------E--
D
---
Y
L
F
Q
V
I
--
L
--
E
K
Q
I
--
R
I
P
-----
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
H
P
-
Q
T
G
F
A
D
-
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
--
P
-----
N
I
S
G
E
F
G
L
D
N
F
D
-
S
Q
F
T
N
E
P
V
Q
L
--
P
D
D
D
D
I
V
R
K
I
D
---------------------
88
Blastp_CBE
48.34
48%
-7
- C2 -
-
3WE4
5.0
-
KS6B1_HUMAN
A:
[21-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
RN
A
K
D
-
T
A
H
T
K
A
E
R
N
I
L
-
E
---
E
-
V
---
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
-----
V
T
--
H
-
F
-
C
-
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
---
G
---
E
----
N
R
---
K
---
K
T
I
D
K
I
--
L
--
K
C
K
L
--
N
L
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
G
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
--
P
-----
L
L
Q
------------------------------------------------------
69
Blastp_CBE
48.09
46%
-25
- C2 -
-
5LI1
6.7
-
KPCI_HUMAN
A:
[7-333]
----------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
---
K
K
---
T
-
D
----
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
--
D
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
---
A
-
S
---
N
-
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
-
E
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
P
G
--
D
T
-
T
--
S
-
F
-
C
-
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
DIV-----------------E--
D
---
Y
L
F
Q
V
I
--
L
--
E
K
Q
I
--
R
I
P
-----
R
-
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
H
P
-
Q
T
G
F
A
D
-
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
--
P
-----
N
I
S
G
E
F
G
L
D
N
F
D
-
S
Q
F
T
N
E
P
V
Q
L
--
P
D
D
D
D
I
V
R
K
I
D
---------------------
64
Blastp_CBE
48.02
45%
-27
- C2 -
-
5LIH
6.5
-
KPCI_HUMAN
A:
[2-337]
----------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
---
K
K
---
T
-
D
----
R
I
Y
A
M
K
V
V
K
K
E
L
V
---------
W
V
Q
T
E
K
H
V
F
E
Q
---
A
-
S
---
N
-
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
-
E
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
P
G
--
D
T
-
T
--
S
-
F
-
C
-
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
DIV-----------------NTE
D
---
Y
L
F
Q
V
I
--
L
--
E
K
Q
I
--
R
I
P
-----
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
H
P
-
Q
T
G
F
A
D
-
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
--
P
-----
N
I
S
G
E
F
G
L
D
N
F
D
-
S
Q
F
T
N
E
P
V
Q
L
--
P
D
D
D
D
I
V
R
K
I
D
---
Q
S
E
---
F
E
G
F
E
Y
------
115
Blastp_CBE
47.97
46%
16
- C2 -
-
4NW5
7.9
-
KS6A3_HUMAN
A:
[30-322]
-------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
----
K
I
---
S
-
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
--
V
R
D
R
V
-
R
T
K
M
E
R
D
I
L
-
V
---
E
-
V
---
N
-
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S
I
D
H
E
--
K
K
A
Y
--
S
-
F
-
C
-
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
---
G
---
K
----
D
R
---
K
---
E
T
M
T
M
I
--
L
--
K
A
K
L
--
G
M
P
-----
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
A
G
P
-
D
G
V
-
E
E
-
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
--
P
------------
T
F
Y
F
D
---------------------------------------------
114
Blastp_CBE
47.89
46%
13
- C2 -
-
4NW6
8.0
-
KS6A3_HUMAN
A:
[30-322]
-------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
----
K
I
---
S
-
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
--
V
R
D
R
V
-
R
T
K
M
E
R
D
I
L
-
V
---
E
-
V
---
N
-
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S
I
D
H
E
--
K
K
A
Y
--
S
-
F
-
C
-
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
---
G
---
K
----
D
R
---
K
---
E
T
M
T
M
I
--
L
--
K
A
K
L
--
G
M
P
-----
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
A
G
P
-
D
G
V
-
E
E
-
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
--
P
------------
T
F
Y
F
D
---------------------------------------------
490
Blastp_CBE
47.64
36%
20
- C2 -
-
5HE3
4.7
-
ARBK1_BOVIN
A:
[157-610]
----------------------------------------------------------------------------------------------------------------------------------------------------
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
-
G
F
G
E
V
Y
G
C
R
K
---
A
D
---
T
-
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
K
--
M
K
Q
G
E
T
L
A
L
N
E
R
I
M
L
-
S
LVS
T
-
G
---
D
-
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
--
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
-
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
F
S
K
K
K
--
P
H
A
S
--
V
-----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V--
A
-----
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
-
H
S
P
F
-----
R
---
Q
HKT
K
----
D
K
---
H
---
E
I
D
R
M
T
--
L
--
T
M
A
V
--
E
L
P
-----
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
--
R
L
G
C
L
G
-
R
G
A
-
Q
E
-
V
K
E
S
P
F
F
R
S
L
D
---
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
--
P
PRGEV
N
A
A
D
A
F
D
I
G
S
F
D
-
E
E
D
T
-
K
G
I
K
L
L
D
S
D
Q
E
----------------------------
100
Blastp_CBE
47.39
46%
-31
- C2 -
-
1XJD
7.1
-
A:
[16-335]
------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
D
F
I
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
F
---
K
K
---
T
-
N
----
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
--
M
D
D
D
V
E
C
T
M
V
E
K
R
V
L
-
S
---
L
-
A
W--
E
-
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
--
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
-
G
--
D
A
K
T
--
N
-
F
-
C
-
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
---
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
-
Q
S
P
F
-----
H
---
G
---
Q
----
D
E
---
E
---
E
L
F
H
S
I
--
R
--
M
D
N
P
--
F
Y
P
-----
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
G
V
R
G
------
D
-
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
-------------------
N
F
D
-
K
E
F
L
-------
F
A
-------------------------------
102
Blastp_CBE
47.22
46%
4
- C2 -
-
5D9K
7.0
-
KS6A3_HUMAN
A:
[30-323]
-------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
----
K
I
---
S
-
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
--
V
R
D
R
V
-
R
T
K
M
E
R
D
I
L
-
V
---
E
-
V
---
N
-
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
------------------
C
-
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
---
G
---
K
----
D
R
---
K
---
E
T
M
T
M
I
--
L
--
K
A
K
L
--
G
M
P
-----
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
A
G
P
-
D
G
V
-
E
E
-
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
--
P
-----
A
------
T
F
Y
F
D
-
P
-------------------------------------------
537
Blastp_CBE
47.18
37%
-56
- C2 -
-
4XX9
6.2
-
PDPK1_HUMAN
A:
[32-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
P
E
S
--
K
Q
A
R
--
A
N
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
---
A
---
G
----
N
E
---
G
---
L
I
F
A
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
-------------------------------------------------------------------
116
Blastp_CBE
47.10
46%
14
- C2 -
-
4NUS
7.7
-
KS6A3_HUMAN
A:
[30-322]
-------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
----
K
I
---
S
-
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
--
V
R
D
R
V
-
R
T
K
M
E
R
D
I
L
-
V
---
E
-
V
---
N
-
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S
I
D
H
E
--
K
K
A
Y
--
S
-
F
-
C
-
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
---
G
---
K
----
D
R
---
K
---
E
T
M
T
M
I
--
L
--
K
A
K
L
--
G
M
P
-----
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
A
G
P
-
D
G
V
-
E
E
-
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
--
P
-----
A
------
T
F
Y
F
D
---------------------------------------------
113
Blastp_CBE
47.10
46%
13
- C2 -
-
5D9L
5.2
-
KS6A3_HUMAN
A:
[30-322]
-------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
----
K
I
---
S
-
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
--
V
R
D
R
V
-
R
T
K
M
E
R
D
I
L
-
V
---
E
-
V
---
N
-
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
-------------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
---
G
---
K
----
D
R
---
K
---
E
T
M
T
M
I
--
L
--
K
A
K
L
--
G
M
P
-----
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
A
G
P
-
D
G
V
-
E
E
-
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
--
P
-----
A
T
G
R
P
E
D
T
F
Y
F
D
---------------------------------------------
579
Fugue
46.99
40%
15
- C2 -
-
1CDK
8.0
-
KAPCA_PIG
A:
[8-350]
---------------------
K
G
-----------------------------------------------------------------------------------------
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
------
H
--
L
D
Q
F
E
R
I
K
T
L
G
T
-G
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
G-----
N
H
F
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
AV-------
N
-
F
P
F
L
V
K
L
E
Y
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I--
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q-
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
-
K
----
G
--
R
TW
T
-
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
S
-KGY-------
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y-
P
P
F
-----
F
AD----------
Q
P
---
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
S-----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
L
K
-
D
G
V
-
N
D
-
I
K
N
H
K
W
F
A
---TTD
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
Y
E
E
E
E
I
R
V
S
I
--------
N
E
K
C
G
K
E
F
S
E
---
F
-----------
448
Blastp_CBE
46.95
39%
-10
- C2 -
-
6C0T
6.1
-
A:
[30-326]
---------------------------------------------------------------------------------------------------------------------------------------------------
N
L
K
L
S
D
F
N
I
I
D
T
L
G
V
G
-
G
F
G
R
V
E
L
V
Q
L
---
K
S
---
E
E
S
----
K
T
F
A
M
K
I
L
K
K
R
H
I
V
--
D
T
R
Q
Q
E
H
I
R
S
E
K
Q
I
M
-
Q
---
G
-
A
---
H
-
S
D
F
I
V
R
L
Y
R
T
F
K
D
S
K
Y
L
Y
M
L
M
E
A
C
L
G
G
E
L
W
T
I
L
R
D
--
R
G
S
F
E
D
S
T
T
R
F
Y
T
A
C
V
V
E
A
F
A
Y
L
H
S
-
K
G
I
I
Y
R
D
L
K
P
E
N
L
I
L
D
-
H
R
G
Y
A
K
L
V
D
F
G
F
A
K
---
K
I
G
--
F
G
K
K
--
T
W
F
-
C
-
G
T
P
E
Y
V
A
P
E
I
I
L
N
K
---
G
-----
H
D
I
S
A
D
Y
W
S
L
G
I
L
M
Y
E
L
L
T
G
-
S
P
P
F
-----
S
---
G
---
P
----
D
P
---
M
---
K
T
Y
N
I
I
--
L
RG
I
D
M
I
--
E
F
P
-----
K
K
I
A
K
N
A
A
N
L
I
K
K
L
C
R
D
N
P
S
E
--
R
L
G
N
L
K
-
N
G
V
-
K
D
-
I
Q
K
H
K
W
F
E
G
F
N
---
W
E
G
L
R
K
G
T
L
T
P
P
I
I
--
P
-----
S
V
A
S
P
T
D
T
S
N
F
D
---------------------------------------------
478
Blastp_CBE
46.44
37%
-51
- C2 -
-
1H1W
5.2
-
PDPK1_HUMAN
A:
[11-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
P
------
A
R
--
A
N
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
---
A
---
G
----
N
E
---
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
-------------------------------------------------------------------
454
Blastp_CBE
46.32
39%
-11
- C2 -
-
6BDL
3.0
-
KGP1_HUMAN
A:
[30-326]
---------------------------------------------------------------------------------------------------------------------------------------------------
N
L
K
L
S
D
F
N
I
I
D
T
L
G
V
G
-
G
F
G
R
V
E
L
V
Q
L
---
K
S
---
E
E
S
----
K
T
F
A
M
K
I
L
K
K
R
H
I
V
--
D
T
R
Q
Q
E
H
I
R
S
E
K
Q
I
M
-
Q
---
G
-
A
---
H
-
S
D
F
I
V
R
L
Y
R
T
F
K
D
S
K
Y
L
Y
M
L
M
E
A
C
L
G
G
E
L
W
T
I
L
R
D
--
R
G
S
F
E
D
S
T
T
R
F
Y
T
A
C
V
V
E
A
F
A
Y
L
H
S
-
K
G
I
I
Y
R
D
L
K
P
E
N
L
I
L
D
-
H
R
G
Y
A
K
L
V
D
F
G
F
A
K
---
K
I
G
--
F
G
K
K
--
T
W
F
-
C
-
G
T
P
E
Y
V
A
P
E
I
I
L
N
K
---
G
-----
H
D
I
S
A
D
Y
W
S
L
G
I
L
M
Y
E
L
L
T
G
-
S
P
P
F
-----
S
---
G
---
P
----
D
P
---
M
---
K
T
Y
N
I
I
--
L
RG
I
D
M
I
--
E
F
P
-----
K
K
I
A
K
N
A
A
N
L
I
K
K
L
C
R
D
N
P
S
E
--
R
L
G
N
L
K
-
N
G
V
-
K
D
-
I
Q
K
H
K
W
F
E
G
F
N
---
W
E
G
L
R
K
G
T
L
T
P
P
I
I
--
P
-----
S
V
A
S
P
T
D
T
S
N
F
D
---------------------------------------------
57
Blastp_CBE
46.22
46%
-22
- C2 -
-
6ILZ
4.5
-
KPCI_HUMAN
C:
[11-332]
---------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
----------
D
----
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
--
D
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
---
A
-
S
---
N
-
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
-
E
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
P
G
--
D
T
-
T
--
S
-
F
-
C
-
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
DI---------------------
D
---
Y
L
F
Q
V
I
--
L
--
E
K
Q
I
--
R
I
P
-----
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
H
P
-
Q
T
G
F
A
D
-
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
--
P
-----
N
I
S
G
E
F
G
L
D
N
F
D
-
S
Q
F
--
E
P
V
Q
L
--
P
D
D
D
D
I
V
R
K
I
D
---------------------
55
Blastp_CBE
46.21
46%
-24
- C2 -
-
6ILZ
4.3
-
KPCI_HUMAN
G:
[11-332]
---------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
----------
D
----
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
--
D
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
---
A
-
S
---
N
-
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
-
E
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
P
G
--
D
T
-
T
--
S
-
F
-
C
-
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
DIV--------------------
D
---
Y
L
F
Q
V
I
--
L
--
E
K
Q
I
--
R
I
P
-----
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
H
P
-
Q
T
G
F
A
D
-
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
--
P
-----
N
I
S
---
G
L
D
N
F
D
-
S
Q
F
T
--
P
V
Q
L
--
P
D
D
D
D
I
V
R
K
I
D
---------------------
101
Blastp_CBE
46.12
46%
6
- C2 -
-
5D9K
6.6
-
KS6A3_HUMAN
B:
[30-323]
-------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
----
K
I
---
S
-
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
--
V
R
D
R
V
-
R
T
K
M
E
R
D
I
L
-
V
---
E
-
V
---
N
-
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
-----------------
C
-
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
---
G
---
K
----
D
R
---
K
---
E
T
M
T
M
I
--
L
--
K
A
K
L
--
G
M
P
-----
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
A
G
P
-
D
G
V
-
E
E
-
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
--
P
------------
T
F
Y
F
D
-
P
-------------------------------------------
63
Blastp_CBE
45.82
45%
-11
- C2 -
-
5LIH
6.0
-
KPCI_HUMAN
B:
[2-337]
----------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
---
K
K
---
T
-
D
----
R
I
Y
A
M
K
V
V
K
K
E
L
-----------
V
Q
T
E
K
H
V
F
E
Q
---
A
-
S
---
N
-
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
-
E
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
P
G
--
D
T
-
T
--
S
-
F
-
C
-
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
DI------------------E--
D
---
Y
L
F
Q
V
I
--
L
--
E
K
Q
I
--
R
I
P
-----
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
H
P
-
Q
T
G
F
A
D
-
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
--
P
-----
N
I
S
G
E
F
G
L
D
N
F
D
-
S
Q
F
T
N
E
P
V
Q
L
--
P
D
D
D
D
I
V
R
K
I
D
---
Q
S
E
---
F
E
G
F
E
Y
------
532
Blastp_CBE
45.61
37%
-51
- C2 -
-
3RWQ
6.8
-
PDPK1_HUMAN
A:
[33-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
P
------
A
R
--
A
N
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
---
A
---
G
----
N
E
---
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
-------------------------------------------------------------------
477
Blastp_CBE
45.48
37%
-50
- C2 -
-
1UVR
3.5
-
PDPK1_HUMAN
A:
[11-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
P
------
A
R
--
A
N
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
---
A
---
G
----
N
E
---
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
M
E
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
-------------------------------------------------------------------
82
Blastp_CBE
44.92
47%
7
- C2 -
-
3A62
9.3
-
KS6B1_HUMAN
A:
[13-300]
---------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
---------------
K
A
E
R
N
I
L
-
E
---
E
-
V
---
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
---------------
F
-
C
-
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
---
G
---
E
----
N
R
---
K
---
K
T
I
D
K
I
--
L
--
K
C
K
L
--
N
L
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
G
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
--
P
-----
L
--------------------------------------------------------
58
Blastp_CBE
44.62
46%
-17
- C2 -
-
6ILZ
4.0
-
KPCI_HUMAN
A:
[11-332]
---------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
----------
D
----
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
--
D
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
---
A
-
S
---
N
-
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
-
E
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
P
G
--
D
T
-
T
--
S
-
F
-
C
-
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
DIV--------------------
D
---
Y
L
F
Q
V
I
--
L
--
E
K
Q
I
--
R
I
P
-----
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
H
P
-
Q
T
G
F
A
D
-
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
--
P
-----
N
I
S
G
E
F
G
L
D
N
F
D
-
S
Q
F
T
N
E
P
V
Q
L
--
P
D
D
D
D
I
V
R
K
I
D
---------------------
138
Blastp_CBE
44.56
46%
11
- C2 -
-
3UBD
7.3
-
KS6A3_MOUSE
A:
[24-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
----
K
I
---
S
-
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
--
V
R
D
R
V
-------
D
I
L
-
V
---
E
-
V
---
N
-
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
-----
E
--
K
K
A
Y
--
S
-
F
-
C
-
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
---
G
---
K
----
D
R
---
K
---
E
T
M
T
M
I
--
L
--
K
A
K
L
--
G
M
P
-----
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
A
G
P
-
D
G
V
-
E
E
-
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
--
P
--------------------------------------------------------------
139
Blastp_CBE
44.37
46%
13
- C2 -
-
4GUE
7.5
-
KS6A3_MOUSE
A:
[25-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
----
K
I
---
S
-
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
--
V
R
D
R
V
---------
L
-
V
---
E
-
V
---
N
-
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
-----
E
--
K
K
A
Y
--
S
-
F
-
C
-
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
---
G
---
K
----
D
R
---
K
---
E
T
M
T
M
I
--
L
--
K
A
K
L
--
G
M
P
-----
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
A
G
P
-
D
G
V
-
E
E
-
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
--
P
--------------------------------------------------------------
140
Blastp_CBE
44.03
46%
17
- C2 -
-
4EL9
6.8
-
KS6A3_MOUSE
A:
[25-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
----
K
I
---
S
-
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
--
V
R
D
R
V
------
R
D
I
L
-
V
---
E
-
V
---
N
-
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S
---
E
--
K
K
A
Y
--
S
-
F
-
C
-
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
---
G
---
K
----
D
R
---
K
---
E
T
M
T
M
I
--
L
--
K
A
K
L
--
G
M
P
-----
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
A
G
P
-
D
G
V
-
E
E
-
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
--
P
--------------------------------------------------------------
111
Blastp_CBE
44.01
45%
9
- C2 -
-
2Z7Q
5.1
-
KS6A1_HUMAN
A:
[25-308]
----------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
S
H
------
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
---
V
T
RPD
S
-
G
----
H
L
Y
A
M
K
V
L
---------------------
I
L
-
A
---
D
-
V
---
N
-
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
-------------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
Q
---
G
-----
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
-
S
L
P
F
-----
Q
---
G
---
K
----
D
R
---
K
---
E
T
M
T
L
I
--
L
--
K
A
K
L
--
G
M
P
-----
Q
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
--
R
L
G
S
G
P
-
D
G
A
-
E
E
-
I
K
R
H
V
F
Y
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
--
P
--------------------------------------------------------------
103
Blastp_CBE
43.86
46%
8
- C2 -
-
3G51
7.5
-
KS6A3_MOUSE
A:
[24-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
----
K
I
---
S
-
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
--
V
----------
R
D
I
L
-
V
---
E
-
V
---
N
-
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S
I
------------------
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
---
G
---
K
----
D
R
---
K
---
E
T
M
T
M
I
--
L
--
K
A
K
L
--
G
M
P
-----
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
A
G
P
-
D
G
V
-
E
E
-
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
--
P
--------------------------------------------------------------
109
Blastp_CBE
43.49
45%
10
- C2 -
-
2Z7S
6.6
-
KS6A1_HUMAN
A:
[25-308]
----------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
S
H
------
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
---
V
T
RPD
S
-
G
----
H
L
Y
A
M
K
V
L
K
--------------------
I
L
-
A
---
D
-
V
---
N
-
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
-------------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
Q
---
G
-----
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
-
S
L
P
F
-----
Q
---
G
---
K
----
D
R
---
K
---
E
T
M
T
L
I
--
L
--
K
A
K
L
--
G
M
P
-----
Q
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
--
R
L
G
S
G
P
-
D
G
A
-
E
E
-
I
K
R
H
V
F
Y
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
--
P
--------------------------------------------------------------
56
Blastp_CBE
43.09
46%
-21
- C2 -
-
6ILZ
5.5
-
KPCI_HUMAN
E:
[12-332]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
----------
D
----
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
--
D
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
---
A
-
S
---
N
-
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
-
E
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
P
G
--
D
T
-
T
--
S
-
F
-
C
-
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
DI---------------------
D
---
Y
L
F
Q
V
I
--
L
--
E
K
Q
I
--
R
I
P
-----
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
H
P
-
Q
T
G
F
A
D
-
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
--
P
-----
N
I
S
G
E
F
G
L
D
N
F
D
-
S
Q
F
T
--
P
V
Q
L
--
P
D
D
D
D
I
V
R
K
I
D
---------------------
110
Blastp_CBE
42.93
45%
20
- C2 -
-
2Z7R
7.5
-
KS6A1_HUMAN
A:
[25-308]
----------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
S
H
------
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
---
V
T
RPD
S
-
G
----
H
L
Y
A
M
K
V
L
K
K
A
T
L
K
--
V
------------
I
L
-
A
---
D
-
V
---
N
-
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
-------------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
Q
---
G
-----
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
-
S
L
P
F
-----
Q
---
G
---
K
----
D
R
---
K
---
E
T
M
T
L
I
--
L
--
K
A
K
L
--
G
M
P
-----
Q
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
--
R
L
G
S
G
P
-
D
G
A
-
E
E
-
I
K
R
H
V
F
Y
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
--
P
--------------------------------------------------------------
87
Blastp_CBE
42.60
48%
1
- C2 -
-
3WF5
6.7
-
KS6B1_HUMAN
A:
[21-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
-------------
T
K
A
E
R
N
I
L
-
E
---
E
-
V
---
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
---
T
V
T
--
H
-
F
-
C
-
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
---
G
---
E
----
N
R
---
K
---
K
T
I
D
K
I
--
L
--
K
C
K
L
--
N
L
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
G
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
--
P
-----
L
L
Q
S
-----------------------------------------------------
86
Blastp_CBE
42.56
48%
2
- C2 -
-
3WF6
6.5
-
KS6B1_HUMAN
A:
[21-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
-------------
T
K
A
E
R
N
I
L
-
E
---
E
-
V
---
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
---
T
V
T
--
H
-
F
-
C
-
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
---
G
---
E
----
N
R
---
K
---
K
T
I
D
K
I
--
L
--
K
C
K
L
--
N
L
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
G
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
--
P
-----
L
L
Q
S
-----------------------------------------------------
308
Blastp_CBE
42.38
45%
17
- C2 -
-
6G77
7.1
-
KS6A6_HUMAN
A:
[30-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
---
K
T
GPD
A
-
G
----
Q
L
Y
A
M
K
V
L
K
K
A
S
L
K
--
V
R
D
---------
D
I
L
-
V
---
E
-
V
---
N
-
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
--
E
V
L
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
Q
L
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
I
G
H
I
K
L
T
D
F
G
L
S
K
E
S
V
D
Q
E
--
K
K
A
Y
--
S
-
F
-
C
-
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
-----
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
---
G
---
K
----
D
R
---
N
---
E
T
M
N
M
I
--
L
--
K
A
K
L
--
G
M
P
-----
Q
F
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
--
G
S
-
E
G
V
-
E
E
-
I
K
R
H
L
F
F
A
N
I
D
---
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
--
P
--------------------------------------------------------------
84
Blastp_CBE
41.95
48%
14
- C2 -
-
3WF8
7.5
-
KS6B1_HUMAN
A:
[21-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
RN
A
K
D
-
T
A
H
T
K
A
E
R
N
I
L
-
E
---
E
-
V
---
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
---
T
V
T
--
H
-
F
-
C
-
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
---
G
---
E
----
N
R
---
K
---
K
T
I
D
K
I
--
L
--
K
C
K
L
--
N
L
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
G
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
--
P
-----
L
L
-------------------------------------------------------
79
Blastp_CBE
41.89
47%
13
- C2 -
-
3A60
8.6
-
KS6B1_HUMAN
A:
[13-299]
---------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
A
M
------------
K
A
E
R
N
I
L
-
E
---
E
-
V
---
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
--------------------
T
I
E
Y
M
A
P
E
I
L
M
R
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
---
G
---
E
----
N
R
---
K
---
K
T
I
D
K
I
--
L
--
K
C
K
L
--
N
L
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
G
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
--
P
--------------------------------------------------------------
313
Blastp_CBE
41.87
45%
13
- C2 -
-
6G78
6.7
-
KS6A6_HUMAN
B:
[30-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
---
K
T
GPD
A
-
G
----
Q
L
Y
A
M
K
V
L
K
K
A
S
L
K
--
V
R
D
---------
D
I
L
-
V
---
E
-
V
---
N
-
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
--
E
V
L
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
Q
L
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
I
G
H
I
K
L
T
D
F
G
L
S
K
E
S
V
-----------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
-----
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
---
G
---
K
----
D
R
---
N
---
E
T
M
N
M
I
--
L
--
K
A
K
L
--
G
M
P
-----
Q
F
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
--
G
S
-
E
G
V
-
E
E
-
I
K
R
H
L
F
F
A
N
I
D
---
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
--
P
--------------------------------------------------------------
77
Blastp_CBE
41.44
47%
18
- C2 -
-
3A61
7.5
-
KS6B1_HUMAN
A:
[15-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
----------------
K
A
E
R
N
I
L
-
E
---
E
-
V
---
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
-----------------------
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
---
G
---
E
----
N
R
---
K
---
K
T
I
D
K
I
--
L
--
K
C
K
L
--
N
L
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
G
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
--
P
--------------------------------------------------------------
78
Blastp_CBE
41.16
47%
21
- C2 -
-
3A60
9.1
-
KS6B1_HUMAN
B:
[13-300]
---------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
--------------------------------
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
----------------
C
-
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
---
G
---
E
----
N
R
---
K
---
K
T
I
D
K
I
--
L
--
K
C
K
L
--
N
L
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
G
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
--
P
-----
L
--------------------------------------------------------
307
Blastp_CBE
41.10
45%
24
- C2 -
-
6G77
8.2
-
KS6A6_HUMAN
B:
[30-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
---
K
T
GPD
A
-
G
----
Q
L
Y
A
M
K
V
L
K
K
A
S
L
K
--
V
R
D
---------
D
I
L
-
V
---
E
-
V
---
N
-
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
--
E
V
L
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
Q
L
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
I
G
H
I
K
L
T
D
F
G
L
S
K
E
S
V
D
Q
E
--
K
K
A
Y
--
S
-
F
-
C
-
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
-----
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
---
G
---
K
----
D
R
---
N
---
E
T
M
N
M
I
--
L
--
K
A
K
L
--
G
M
P
-----
Q
F
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
--
G
S
-
E
G
V
-
E
E
-
I
K
R
H
L
F
F
A
N
I
D
---
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
--
P
--------------------------------------------------------------
314
Blastp_CBE
40.94
45%
16
- C2 -
-
6G78
8.5
-
KS6A6_HUMAN
A:
[30-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
---
K
T
GPD
A
-
G
----
Q
L
Y
A
M
K
V
L
K
K
A
S
L
K
--
V
R
D
---------
D
I
L
-
V
---
E
-
V
---
N
-
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
--
E
V
L
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
Q
L
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
I
G
H
I
K
L
T
D
F
G
L
S
K
E
S
V
D
Q
---------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
-----
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
---
G
---
K
----
D
R
---
N
---
E
T
M
N
M
I
--
L
--
K
A
K
L
--
G
M
P
-----
Q
F
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
--
G
S
-
E
G
V
-
E
E
-
I
K
R
H
L
F
F
A
N
I
D
---
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
--
P
--------------------------------------------------------------
83
Blastp_CBE
40.81
48%
15
- C2 -
-
3WF9
7.4
-
KS6B1_HUMAN
A:
[21-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
RN
A
K
D
-
T
A
H
T
K
A
E
R
N
I
L
-
E
---
E
-
V
---
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
---
T
V
T
--
H
-
F
-
C
-
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
---
G
---
E
----
N
R
---
K
---
K
T
I
D
K
I
--
L
--
K
C
K
L
--
N
L
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
G
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
--
P
-----
L
L
-------------------------------------------------------
429
Blastp_CBE
40.22
46%
-7
- C2 -
-
6G76
5.8
-
KS6A6_HUMAN
A:
[30-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
---
K
T
GPD
A
-
G
----
Q
L
Y
A
M
K
V
L
K
K
A
S
L
K
--
V
R
D
---------
D
I
L
-
V
---
E
-
V
---
N
-
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
--
E
V
L
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
Q
L
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
I
G
H
I
K
L
T
D
F
G
L
S
K
E
S
V
-
D
Q
--
E
K
K
A
--
Y
-
F
-
C
-
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
-----
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
---
G
---
K
----
D
R
---
N
---
E
T
M
N
M
I
--
L
--
K
A
K
L
--
G
M
P
-----
Q
F
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
--
G
S
-
E
G
V
-
E
E
-
I
K
R
H
L
F
F
A
N
I
D
---
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
--
P
--------------------------------------------------------------
428
Blastp_CBE
39.51
46%
8
- C2 -
-
6G76
6.8
-
KS6A6_HUMAN
B:
[30-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
---
K
T
GPD
A
-
G
----
Q
L
Y
A
M
K
V
L
K
K
A
S
L
K
--
V
----------
R
D
I
L
-
V
---
E
-
V
---
N
-
H
P
F
I
V
K
L
H
Y
A
F
Q
T
--
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
--
E
V
L
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
Q
L
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
I
G
H
I
K
L
T
D
F
G
L
S
K
E
S
V
-
D
-----------------
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
-----
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
---
G
---
K
----
D
R
---
N
---
E
T
------------
L
--
G
M
P
-----
Q
F
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
--
G
S
-
E
G
V
-
E
E
-
I
K
R
H
L
F
F
A
N
I
D
---
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
--
P
--------------------------------------------------------------
107
Blastp_CBE
39.16
49%
26
- C2 -
-
4RLO
9.0
-
KS6B1_HUMAN
B:
[7-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
--------------------------------
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
------------------
T
I
E
Y
M
A
P
E
I
L
M
R
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
---
G
---
E
----
N
R
---
K
---
K
T
I
D
K
I
--
L
--
K
C
K
L
--
N
L
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
G
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
--
P
--------------------------------------------------------------
81
Blastp_CBE
26.85
43%
33
- C2 -
-
3PFQ
Error
-
KPCB_RAT
A:
[146-647]
---------------------------------------------------------------------------------------
F
N
V
P
-
P
P
E
GSEG
N
E
E
L
R
Q
K
F
E
R
A
K
I
G
Q
G
T
K
A
P
E
E
K
T
A
N
T
I
S
K
F
D
N
N
G
N
R
D
----------
R
M
K
L
T
D
F
N
F
L
M
V
L
G
K
G
-
S
F
G
K
V
M
L
S
E
R
---
K
G
---
T
-
D
----
E
L
Y
A
V
K
I
L
K
K
D
V
V
I
--
Q
D
D
D
V
E
C
T
M
V
E
K
R
V
L
-
A
L--
P
-
G
---
K
-
P
P
F
L
T
Q
L
H
S
C
F
Q
T
M
D
R
L
Y
F
V
M
E
Y
V
N
G
G
D
L
M
Y
H
I
Q
Q
--
V
G
R
F
K
E
P
H
A
V
F
Y
A
A
E
I
A
I
G
L
F
F
L
Q
S
-
K
G
I
I
Y
R
D
L
K
L
D
N
V
M
L
D
-
S
E
G
H
I
K
I
A
D
F
G
M
C
K
E
N
I
W
D
G
--
V
T
T
K
----
F
-
C
-
G
T
P
D
Y
I
A
P
E
I
I
A
Y
Q
---
P
-----
Y
G
K
S
V
D
W
W
A
F
G
V
L
L
Y
E
M
L
A
G
-
Q
A
P
F
-----
E
---
G
---
E
----
D
E
---
D
---
E
L
F
Q
S
I
--
M
--
E
H
N
V
--
A
Y
P
-----
K
S
M
S
K
E
A
V
A
I
C
K
G
L
M
T
K
H
P
G
K
--
R
L
G
C
G
P
-
E
G
E
-
R
D
-
I
K
E
H
A
F
F
R
Y
I
D
---
W
E
K
L
E
R
K
E
I
Q
P
P
Y
K
--
P
-----
K
A
S
G
R
-
N
A
E
N
F
D
-
R
F
F
T
-
R
H
P
P
V
L
P
P
D
Q
E
----------------------------
-
* C *
-
:
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
:
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------