@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Screening
Virtual Screening Score
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : AKT2_HUMAN: (2020-09-04 )
MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAECQLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPMDYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSASIRE
Atome Classification :
(443 SA)
.........10........20........30...-......40........50........60........70........80........90........100.......110.......120.......130.......--140.......150.......160........170--..---.-.----....180.......--190........200..-.---..---.-.210.......220.......230.......240.--......250.......260......-.-270.......280..-.....290......--.300..-....--.-310--........320..-----.---.-----...330.......340....-...350---.--.---...----.---...360--.--....--..370---.........380.......390-....------.-.-..400.-.......410.---......420.....--.-----.430.......440........450.......460.......---470-........480
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(pKd)
(pKd)
(Uniprot)
MN
E
V
S
V
I
K
E
G
W
L
H
KRG
E
Y
I
KTWR
P
R
Y
F
L
L
K-SDG-
S
F
IGYKERPEAPDQTLPPLNNFS
V
A
E
C
Q
L
MKTERPRP
N
T
F
V
I
R
C
L
Q
W
T
T
V
I
E
R
TFHVDS
P
D
E
R
E
E
W
M
R
A
I
Q
M
V
A
N
S
L
K
QRAPGEDPMDYKCGSPSDSS
T
T
E
E
M
E
V
A
--
V
S
KA
R
A
K
V
TMN
D
F
D
Y
L
K
L
LGKG-TF
G
K
V
I
L
V
R
E---KA---T-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I--A-
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-Q---NT---R-
H
P
F
L
T
A
L
K
Y
A
F
QTHD
R
L
C
F
V
M
E
YANG
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S-R-D
V
V
Y
R
D
I
K
L
E
N
L
M
LD-KDG
H
I
K
I
T
D
F
G
L
C
K
--EGISDG-A
T
M
K--T-F-C--G
T
P
E
Y
L
A
P
E
VLED-----N---D-----YGR
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
CG-RLPF-----Y--N---Q
D
H
----
E
---
R
L
F
E
L
I
--
L
--
M
E
EI--RFP-----RTLS
P
E
A
K
S
L
L
A
G
L
L
KK
D
P
K
Q
--RLGG------G-
P
-
S
D
A
-
K
E
-
V
M
EH
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
KLLPPFK--P-----QVTSEVDTRYFD-DEFTA
Q
S
I
T
ITPPDRYDSLG
L
L
E
LDQRTH---FP--QFSYSASIRE
6
PsiBlast_PDB
91.12
83%
-62
- C2 -
-
6HHJ
11.0
-
AKT1_HUMAN
A:
[3-444]
--
D
V
A
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
K
T
W
R
P
R
Y
F
L
L
K
-
N
D
G
-
T
F
I
G
Y
K
E
R
P
Q
--
D
Q
R
E
A
P
L
N
N
F
S
V
A
Q
C
Q
L
M
K
T
E
R
P
R
P
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
T
F
H
V
E
T
P
E
E
R
E
E
W
T
T
A
I
Q
T
V
A
D
G
L
K
K
Q
----------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
-
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
---
N
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
I
K
D
G
-
A
T
M
K
--
T
-
F
-
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
D
H
----
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
-
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
E
F
T
A
-----------------------------------------
8
PsiBlast_PDB
89.94
83%
-60
- C2 -
-
6S9W
9.8
-
?
A:
[3-444]
--
D
V
A
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
K
T
W
R
P
R
Y
F
L
L
K
-
N
D
G
-
T
F
I
G
Y
K
E
R
P
Q
D
V
D
Q
R
E
A
P
L
N
N
F
S
V
A
Q
C
Q
L
M
K
T
E
R
P
R
P
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
T
F
H
V
E
T
P
E
E
R
E
E
W
T
T
A
I
Q
T
V
A
D
G
L
K
K
---------------------------------
K
H
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
-
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
---
N
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
I
K
---
A
T
M
K
--
T
-
F
-
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
D
H
----
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
-
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
E
F
T
A
-----------------------------------------
24
Blastp_CBE
88.39
99%
-113
- C2 -
-
3D0E
9.2
-
AKT2_HUMAN
B:
[1-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
-
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
---
N
T
---
R
-
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
I
S
D
G
-
A
T
M
K
--
T
-
F
-
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
D
H
----
E
---
R
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
-
P
-
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
--
P
-----
Q
V
T
S
E
V
D
T
R
Y
F
D
-
D
E
F
T
A
Q
S
I
T
I
-
P
P
D
----------
D
Q
R
T
H
---
F
P
--
Q
F
D
Y
S
A
S
I
R
-
16
PsiBlast_PDB
88.11
99%
-117
- C2 -
-
3E88
9.2
-
AKT2_HUMAN
A:
[1-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
-
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
---
N
T
---
R
-
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
I
S
D
G
-
A
T
M
K
--
T
-
F
-
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
D
H
----
E
---
R
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
-
P
-
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
--
P
-----
Q
V
T
S
E
V
D
T
R
Y
F
D
-
D
E
F
T
A
Q
S
I
T
I
T
--------------
Q
R
T
H
---
F
P
--
Q
F
D
Y
S
A
S
I
R
-
22
Blastp_CBE
87.94
99%
-116
- C2 -
-
3E88
9.4
-
AKT2_HUMAN
B:
[1-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
-
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
---
N
T
---
R
-
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
I
S
D
G
-
A
T
M
K
--
T
-
F
-
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
D
H
----
E
---
R
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
-
P
-
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
--
P
-----
Q
V
T
S
E
V
D
T
R
Y
F
D
-
D
E
F
T
A
Q
S
I
T
I
--------------
D
Q
R
T
H
---
F
P
--
Q
F
D
Y
S
A
S
I
R
-
18
PsiBlast_PDB
87.65
99%
-117
- C2 -
-
3D0E
9.2
-
AKT2_HUMAN
A:
[1-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
-
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
---
N
T
---
R
-
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
I
S
D
G
-
A
T
M
K
--
T
-
F
-
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
D
H
----
E
---
R
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
-
P
-
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
--
P
-----
Q
V
T
S
E
V
D
T
R
Y
F
D
-
D
E
F
T
A
Q
S
I
T
I
T
P
P
-----------
D
Q
R
T
H
---
F
P
--
Q
F
D
Y
S
A
S
I
R
-
21
Blastp_CBE
87.46
99%
-117
- C2 -
-
3E8D
8.8
-
AKT2_HUMAN
B:
[1-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
-
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
---
N
T
---
R
-
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
I
S
D
G
-
A
T
M
K
--
T
-
F
-
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
D
H
----
E
---
R
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
-
P
-
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
--
P
-----
Q
V
T
S
E
V
D
T
R
Y
F
D
-
D
E
F
T
A
Q
S
I
-----------------
Q
R
T
H
---
F
P
--
Q
F
D
Y
S
A
S
I
R
-
5
PsiBlast_PDB
87.29
83%
-56
- C2 -
-
6HHI
10.3
-
AKT1_HUMAN
A:
[3-444]
--
D
V
A
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
K
T
W
R
P
R
Y
F
L
L
K
-
N
D
G
-
T
F
I
G
Y
K
E
R
P
Q
D
---
R
E
A
P
L
N
N
F
S
V
A
Q
C
Q
L
M
K
T
E
R
P
R
P
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
T
F
H
V
E
T
P
E
E
R
E
E
W
T
T
A
I
Q
T
V
A
D
G
L
K
K
-----------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
--------------------
Q
---
N
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
I
K
----
T
M
K
--
T
-
F
-
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
D
H
----
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
-
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
E
F
T
A
-----------------------------------------
15
PsiBlast_PDB
87.26
99%
-113
- C2 -
-
3E87
6.7
-
AKT2_HUMAN
A:
[1-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
-
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
---
N
T
---
R
-
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
I
S
D
G
-
A
T
M
K
--
T
-
F
-
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
D
H
----
E
---
R
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
-
P
-
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
--
P
-----
Q
V
T
S
E
V
D
T
R
Y
F
D
-
D
E
F
T
A
Q
S
I
T
I
T
P
P
------------
Q
R
T
H
---
F
P
--
Q
F
D
Y
S
A
S
I
R
-
3
PsiBlast_PDB
87.26
83%
-55
- C2 -
-
6HHG
9.3
-
AKT1_HUMAN
A:
[3-444]
--
D
V
A
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
K
T
W
R
P
R
Y
F
L
L
K
-
N
D
G
-
T
F
I
G
Y
K
E
R
P
Q
D
----
E
A
P
L
N
N
F
S
V
A
Q
C
Q
L
M
K
T
E
R
P
R
P
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
T
F
H
V
E
T
P
E
E
R
E
E
W
T
T
A
I
Q
T
V
A
D
G
L
K
K
-----------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-------------------------
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
I
K
----
T
M
K
--
T
-
F
-
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
D
H
----
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
-
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
E
F
T
A
-----------------------------------------
14
PsiBlast_PDB
87.20
99%
-115
- C2 -
-
1O6K
7.8
-
AKT2_HUMAN
A:
[1-334]
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
-
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
---
N
T
---
R
-
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
I
S
D
G
-
A
T
M
K
--
T
-
F
-
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
D
H
----
E
---
R
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
-
P
-
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
--
P
-----
Q
V
T
S
E
V
D
T
R
Y
F
D
-
D
E
F
T
A
Q
S
I
T
----------------
Q
R
T
H
---
F
P
--
Q
F
D
Y
S
A
S
I
--
570
HHSearch
87.19
96%
-115
- C2 -
-
2JDO
6.4
-
AKT2_HUMAN
A:
[6-341]
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
-
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
---
N
T
---
R
-
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
I
S
D
G
-
A
T
M
K
--
T
-
F
-
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
D
H
----
E
---
R
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
-
P
-
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
--
P
-----
Q
V
T
S
E
V
D
T
R
Y
F
D
-
D
E
F
T
A
Q
S
I
T
-------------------
M
---
F
E
--
D
F
D
Y
I
A
D
---
23
Blastp_CBE
86.90
99%
-111
- C2 -
-
3E87
6.9
-
AKT2_HUMAN
B:
[1-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
-
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
---
N
T
---
R
-
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
I
S
D
G
-
A
T
M
K
--
T
-
F
-
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
D
H
----
E
---
R
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
-
P
-
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
--
P
-----
Q
V
T
S
E
V
D
T
R
Y
F
D
-
D
E
F
T
A
Q
S
I
T
I
-
P
P
-----------
D
Q
R
T
H
---
F
P
--
Q
F
D
Y
S
A
S
I
R
-
17
PsiBlast_PDB
86.64
99%
-118
- C2 -
-
3E8D
8.4
-
AKT2_HUMAN
A:
[1-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
-
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
---
N
T
---
R
-
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
I
S
D
G
-
A
T
M
K
--
T
-
F
-
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
D
H
----
E
---
R
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
-
P
-
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
--
P
-----
Q
V
T
S
E
V
D
T
R
Y
F
D
-
D
E
F
T
A
Q
S
I
-------------------
T
H
---
F
P
--
Q
F
D
Y
S
A
S
I
R
-
19
PsiBlast_PDB
86.63
97%
-112
- C2 -
-
2JDO
6.4
-
AKT2_HUMAN
A:
[6-340]
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
-
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
---
N
T
---
R
-
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
I
S
D
G
-
A
T
M
K
--
T
-
F
-
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
D
H
----
E
---
R
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
-
P
-
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
--
P
-----
Q
V
T
S
E
V
D
T
R
Y
F
D
-
D
E
F
T
A
Q
S
I
T
--------------------M--
F
E
--
D
F
D
Y
I
A
----
9
PsiBlast_PDB
86.19
83%
-56
- C2 -
-
6S9X
10.3
-
?
A:
[3-443]
--
D
V
A
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
K
T
W
R
P
R
Y
F
L
L
K
-
N
D
G
-
T
F
I
G
Y
K
E
R
P
Q
D
----
E
A
P
L
N
N
F
S
V
A
Q
C
Q
L
M
K
T
E
R
P
R
P
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
T
F
H
V
E
T
P
E
E
R
E
E
W
T
T
A
I
Q
T
V
A
D
G
L
K
------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
--------------------
Q
---
N
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
I
K
-----------
F
-
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
D
H
----
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
-
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
E
F
T
------------------------------------------
28
Blastp_CBE
86.03
97%
-117
- C2 -
-
1O6L
7.9
-
AKT2_HUMAN
A:
[1-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
-
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
---
N
T
---
R
-
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
I
S
D
G
-
A
T
M
K
--
T
-
F
-
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
D
H
----
E
---
R
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
-
P
-
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
--
P
-----
Q
V
T
S
E
V
D
T
R
Y
F
D
-
D
E
F
T
A
Q
S
I
T
--------------------QEM
F
E
--
D
F
D
Y
I
A
----
7
PsiBlast_PDB
85.96
83%
-65
- C2 -
-
6HHF
10.1
-
AKT1_HUMAN
A:
[3-439]
--
D
V
A
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
K
T
W
R
P
R
Y
F
L
L
K
-
N
D
G
-
T
F
I
G
Y
K
E
R
P
--------
P
L
N
N
F
S
V
A
Q
C
Q
L
M
K
T
E
R
P
R
P
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
T
F
H
V
E
T
P
E
E
R
E
E
W
T
T
A
I
Q
T
V
A
D
G
L
K
K
Q
-----------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-------------------------
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
-----------------------
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
D
H
----
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
-
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
-----------------------------------------------
25
Blastp_CBE
85.69
97%
-118
- C2 -
-
2XH5
8.5
-
AKT2_HUMAN
A:
[6-340]
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
-
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
---
N
T
---
R
-
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
I
S
D
G
-
A
T
M
K
--
T
-
F
-
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
D
H
----
E
---
R
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
-
P
-
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
--
P
-----
Q
V
T
S
E
V
D
T
R
Y
F
D
-
D
E
F
T
A
Q
S
I
T
--------------------QEM
F
E
--
D
F
D
Y
I
A
----
20
PsiBlast_PDB
85.68
97%
-116
- C2 -
-
2JDR
8.8
-
AKT2_HUMAN
A:
[6-340]
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
-
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
---
N
T
---
R
-
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
I
S
D
G
-
A
T
M
K
--
T
-
F
-
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
D
H
----
E
---
R
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
-
P
-
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
--
P
-----
Q
V
T
S
E
V
D
T
R
Y
F
D
-
D
E
F
T
A
Q
S
I
T
--------------------QEM
F
E
--
D
F
D
Y
I
A
----
26
Blastp_CBE
85.67
97%
-115
- C2 -
-
2X39
7.6
-
AKT2_HUMAN
A:
[6-340]
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
-
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
---
N
T
---
R
-
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
I
S
D
G
-
A
T
M
K
--
T
-
F
-
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
D
H
----
E
---
R
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
-
P
-
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
--
P
-----
Q
V
T
S
E
V
D
T
R
Y
F
D
-
D
E
F
T
A
Q
S
I
T
--------------------QEM
F
E
--
D
F
D
Y
I
A
----
27
Blastp_CBE
85.53
97%
-113
- C2 -
-
2UW9
6.5
-
AKT2_HUMAN
A:
[6-340]
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
-
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
---
N
T
---
R
-
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
I
S
D
G
-
A
T
M
K
--
T
-
F
-
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
D
H
----
E
---
R
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
-
P
-
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
--
P
-----
Q
V
T
S
E
V
D
T
R
Y
F
D
-
D
E
F
T
A
Q
S
I
T
--------------------QEM
F
E
--
D
F
D
Y
I
A
----
4
PsiBlast_PDB
85.43
83%
-52
- C2 -
-
6HHH
9.0
-
AKT1_HUMAN
A:
[2-439]
-
S
D
V
A
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
K
T
W
R
P
R
Y
F
L
L
K
-
N
D
G
-
T
F
I
G
Y
K
E
R
P
Q
D
V
---
E
A
P
L
N
N
F
S
V
A
Q
C
Q
L
M
K
T
E
R
P
R
P
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
T
F
H
V
E
T
P
E
E
R
E
E
W
T
T
A
I
Q
T
V
A
D
G
L
K
K
-----------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
-----------------
R
V
L
-
Q
---
N
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
------------------
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
D
H
----
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
-
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
-----------------------------------------------
2
PsiBlast_PDB
85.24
83%
-63
- C2 -
-
4EJN
11.6
-
AKT1_HUMAN
A:
[4-438]
---
V
A
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
K
T
W
R
P
R
Y
F
L
L
K
-
N
D
G
-
T
F
I
G
Y
K
E
R
P
-------
A
P
L
N
N
F
S
V
A
Q
C
Q
L
M
K
T
E
R
P
R
P
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
T
F
H
V
E
T
P
E
E
R
E
E
W
T
T
A
I
Q
T
V
A
D
G
--------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
----------------
V
L
-
Q
---
N
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
I
K
------
K
--
T
-
F
-
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
D
H
----
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
-
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
------------------------------------------------
10
PsiBlast_PDB
83.85
82%
-70
- C2 -
-
3O96
8.9
-
AKT1_HUMAN
A:
[5-432]
-
S
D
V
A
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
K
T
W
R
P
R
Y
F
L
L
K
-
N
D
G
-
T
F
I
G
Y
K
E
R
P
Q
D
V
---
E
A
P
L
N
N
F
S
V
A
Q
C
Q
L
M
K
T
E
R
P
R
P
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
T
F
---
T
P
E
E
R
E
E
W
T
T
A
I
Q
T
V
A
D
G
L
K
K
Q
-----------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
-----------
N
R
V
L
-
Q
---
N
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
---------------------
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
D
H
----
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
-
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
---------------------------------------------------------
551
Fugue
83.46
88%
-66
- C2 -
-
5KCV
9.2
-
AKT1_HUMAN
A:
[20-452]
-----
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
-
T
W
R
P
R
Y
F
L
L
K
-
N
D
G
-
T
F
I
G
Y
K
E
R
P
-------
A
P
L
N
N
F
S
V
A
Q
C
Q
L
M
K
T
E
R
P
R
P
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
T
F
H
V
E
T
P
E
E
R
E
E
W
T
T
A
I
Q
-------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
--------------------
V
L
-
Q
---
N
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
-------------------------
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
D
H
----
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
-
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
------------------------------------------------
1
PsiBlast_PDB
82.43
83%
-66
- C2 -
-
5KCV
9.5
-
AKT1_HUMAN
A:
[20-452]
-----
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
-
T
W
R
P
R
Y
F
L
L
K
-
N
D
G
-
T
F
I
G
Y
K
E
R
P
-------
A
P
L
N
N
F
S
V
A
Q
C
Q
L
M
K
T
E
R
P
R
P
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
T
F
H
V
E
T
P
E
E
R
E
E
W
T
T
A
I
Q
-------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
--------------------
V
L
-
Q
---
N
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
-------------------------
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
D
H
----
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
-
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
------------------------------------------------
569
HHSearch
81.56
82%
5
- C2 -
-
6S9W
9.8
-
?
A:
[3-444]
--
D
V
A
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
K
T
W
R
P
R
Y
F
L
L
K
-
N
D
G
T
F
I
G
Y
K
E
R
P
Q
D
V
-
D
Q
R
E
A
P
L
N
N
F
S
V
A
Q
C
Q
L
M
K
T
E
R
P
R
P
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
T
F
H
V
E
T
P
E
E
R
E
E
W
T
T
A
I
Q
T
V
A
D
G
L
K
K
---------------------------------
K
H
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
-
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
---
N
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
I
K
---
A
T
M
K
--
T
-
F
-
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
D
H
----
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
-
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
E
F
T
A
-----------------------------------------
568
HHSearch
78.78
82%
6
- C2 -
-
6S9X
10.3
-
?
A:
[3-443]
--
D
V
A
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
K
T
W
R
P
R
Y
F
L
L
K
-
N
D
G
T
F
I
G
Y
K
E
R
P
Q
D
-----
E
A
P
L
N
N
F
S
V
A
Q
C
Q
L
M
K
T
E
R
P
R
P
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
T
F
H
V
E
T
P
E
E
R
E
E
W
T
T
A
I
Q
T
V
A
D
G
L
K
------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
--------------------
Q
---
N
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
I
K
-----------
F
-
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
D
H
----
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
-
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
E
F
T
------------------------------------------
567
HHSearch
76.65
82%
-2
- C2 -
-
4EJN
11.6
-
AKT1_HUMAN
A:
[4-438]
---
V
A
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
K
T
W
R
P
R
Y
F
L
L
K
N
D
G
T
-
F
I
G
Y
K
E
R
P
--------
A
P
L
N
N
F
S
V
A
Q
C
Q
L
M
K
T
E
R
P
R
P
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
T
F
H
V
E
T
P
E
E
R
E
E
W
T
T
A
I
Q
T
V
A
D
G
--------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
----------------
V
L
-
Q
---
N
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
I
K
------
K
--
T
-
F
-
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
D
H
----
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
-
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
------------------------------------------------
41
Blastp_CBE
75.98
85%
-31
- C2 -
-
4GV1
7.8
-
AKT1_HUMAN
A:
[3-337]
----------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
-
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
---
N
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
I
K
D
G
-
A
T
M
K
--
T
-
F
-
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
D
H
----
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
-
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
E
F
T
A
Q
M
I
T
I
T
P
-----
S
M
E
C
V
D
S
E
R
R
P
H
---
F
P
--
Q
F
D
Y
S
A
S
---
571
HHSearch
75.66
86%
-32
- C2 -
-
4GV1
7.8
-
AKT1_HUMAN
A:
[5-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
-
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
---
N
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
I
K
D
G
-
A
T
M
K
--
T
-
F
-
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
D
H
----
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
-
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
E
F
T
A
Q
M
I
T
I
T
P
-----
S
M
E
C
V
D
S
E
R
R
P
H
---
F
P
--
Q
F
D
Y
S
A
S
---
34
Blastp_CBE
75.26
85%
-33
- C2 -
-
3QKM
9.6
-
AKT1_HUMAN
A:
[5-338]
-----------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
-
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
---
N
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
I
K
D
G
-
A
T
M
K
--
T
-
F
-
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
D
H
----
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
-
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
E
F
T
A
Q
M
I
T
I
T
P
-----
S
M
E
C
V
D
S
E
R
R
P
H
---
F
P
--
Q
F
D
Y
S
A
S
---
36
Blastp_CBE
74.87
85%
-39
- C2 -
-
3QKK
7.4
-
AKT1_HUMAN
A:
[5-338]
-----------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
-
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
---
N
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
I
K
D
G
-
A
T
M
K
--
T
-
F
-
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
D
H
----
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
-
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
E
F
T
A
Q
M
I
T
I
--------
M
E
C
V
D
S
E
R
R
P
H
---
F
P
--
Q
F
D
Y
S
A
S
---
48
Blastp_CBE
74.48
85%
-35
- C2 -
-
6CCY
9.9
-
AKT1_HUMAN
A:
[4-339]
-----------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
-
K
D
E
V
A
H
T
L
T
E
S
R
V
L
-
Q
---
N
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
I
K
D
G
-
A
T
M
K
--
T
-
F
-
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
D
H
----
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
-
P
-
S
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
V
D
T
R
Y
F
D
-
E
E
F
T
A
Q
M
I
T
I
T
-----------------
E
QEM
F
R
--
D
F
D
Y
I
A
----
35
Blastp_CBE
74.43
85%
-31
- C2 -
-
3QKL
9.0
-
AKT1_HUMAN
A:
[5-338]
-----------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
-
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
---
N
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
I
K
D
G
-
A
T
M
K
--
T
-
F
-
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
D
H
----
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
-
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
E
F
T
A
Q
M
I
T
-----------------
R
P
H
---
F
P
--
Q
F
D
Y
S
A
S
---
31
Blastp_CBE
74.01
85%
-28
- C2 -
-
4EKL
8.5
-
AKT1_HUMAN
A:
[5-338]
-----------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
-
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
---
N
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
I
K
D
G
-
A
T
M
K
--
T
-
F
-
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
D
H
----
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
-
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
E
F
T
A
Q
M
I
T
I
T
P
-----
S
M
E
C
V
D
S
E
R
R
P
H
---
F
P
--
Q
F
D
Y
S
A
S
---
32
Blastp_CBE
73.91
85%
-35
- C2 -
-
4EKK
7.3
-
AKT1_HUMAN
B:
[5-338]
-----------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
-
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
---
N
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
I
K
D
G
-
A
T
M
K
--
T
-
F
-
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
D
H
----
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
-
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
E
F
T
A
Q
M
I
---------------
S
E
R
R
P
H
---
F
P
--
Q
F
D
Y
S
A
S
---
44
Blastp_CBE
73.65
86%
-31
- C2 -
-
3CQW
6.4
-
AKT1_HUMAN
A:
[6-339]
-----------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
-
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
---
N
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
I
K
D
G
-
A
T
M
K
--
T
-
F
-
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
D
H
----
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
-
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
E
F
T
A
Q
M
I
----------------
E
R
R
P
H
---
F
P
--
Q
F
D
Y
S
A
S
---
42
Blastp_CBE
73.61
86%
-32
- C2 -
-
3MVH
7.7
-
AKT1_HUMAN
A:
[7-338]
------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
-
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
---
N
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
I
K
D
G
-
A
T
M
K
--
T
-
F
-
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
D
H
----
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
-
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
E
F
T
A
Q
--------------------
R
P
H
---
F
P
--
Q
F
D
Y
S
A
----
45
Blastp_CBE
73.43
86%
-31
- C2 -
-
3CQU
8.5
-
AKT1_HUMAN
A:
[6-339]
-----------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
-
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
---
N
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
I
K
D
G
-
A
T
M
K
--
T
-
F
-
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
D
H
----
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
-
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
E
F
T
A
Q
M
----------------
S
E
R
R
P
H
---
F
P
--
Q
F
D
Y
S
A
S
---
39
Blastp_CBE
73.33
85%
-31
- C2 -
-
3OCB
7.2
-
AKT1_HUMAN
B:
[5-338]
-----------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
-
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
---
N
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
I
K
D
G
-
A
T
M
K
--
T
-
F
-
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
D
H
----
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
-
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
E
F
T
A
Q
M
I
T
I
T
---------------
R
P
H
---
F
P
--
Q
F
D
Y
S
A
S
---
37
Blastp_CBE
73.16
85%
-32
- C2 -
-
3OW4
6.7
-
AKT1_HUMAN
B:
[5-338]
-----------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
-
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
---
N
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
I
K
D
G
-
A
T
M
K
--
T
-
F
-
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
D
H
----
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
-
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
E
F
T
A
Q
M
I
T
-----------------
R
P
H
---
F
P
--
Q
F
D
Y
S
A
S
---
43
Blastp_CBE
73.08
86%
-31
- C2 -
-
3MV5
5.9
-
AKT1_HUMAN
A:
[6-339]
-----------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
-
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
---
N
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
I
K
D
G
-
A
T
M
K
--
T
-
F
-
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
D
H
----
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
-
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
E
F
T
A
Q
M
I
------------------
R
P
H
---
F
P
--
Q
F
D
Y
S
A
S
---
40
Blastp_CBE
72.82
85%
-28
- C2 -
-
3OCB
6.6
-
AKT1_HUMAN
A:
[5-338]
-----------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
-
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
---
N
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
I
K
D
G
-
A
T
M
K
--
T
-
F
-
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
D
H
----
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
-
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
E
F
T
A
Q
M
-------------------
R
P
H
---
F
P
--
Q
F
D
Y
S
A
S
---
38
Blastp_CBE
72.72
85%
-29
- C2 -
-
3OW4
6.9
-
AKT1_HUMAN
A:
[5-338]
-----------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
-
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
---
N
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
I
K
D
G
-
A
T
M
K
--
T
-
F
-
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
D
H
----
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
-
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
E
F
T
A
Q
M
I
T
-----------------
R
P
H
---
F
P
--
Q
F
D
Y
S
A
S
---
33
Blastp_CBE
72.69
85%
-25
- C2 -
-
4EKK
6.9
-
AKT1_HUMAN
A:
[5-338]
-----------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
-
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
---
N
S
---
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
I
K
D
G
-
A
T
M
K
--
T
-
F
-
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
D
H
----
E
---
K
L
F
E
L
I
--
L
--
M
E
E
I
--
R
F
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
-
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
--
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
E
F
T
A
Q
M
I
---------------
S
E
R
R
P
H
---
F
P
--
Q
F
D
Y
S
A
S
---
145
Blastp_CBE
70.36
43%
-102
- C2 -
-
5N32
4.8
-
KAPCA_CRIGR
A:
[33-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
-
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
355
Blastp_CBE
70.30
43%
-104
- C2 -
-
5N1O
5.0
-
KAPCA_CRIGR
A:
[31-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
-
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
315
Blastp_CBE
70.29
43%
-100
- C2 -
-
6EMB
6.4
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
350
Blastp_CBE
70.12
43%
-98
- C2 -
-
5N3A
4.0
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
308
Blastp_CBE
70.05
43%
-100
- C2 -
-
6I2A
6.4
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
143
Blastp_CBE
70.03
43%
-95
- C2 -
-
5N7U
4.0
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
346
Blastp_CBE
69.95
43%
-100
- C2 -
-
5N3E
3.8
-
KAPCA_CRIGR
A:
[34-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
162
Blastp_CBE
69.94
43%
-99
- C2 -
-
5LCP
6.1
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
304
Blastp_CBE
69.88
43%
-98
- C2 -
-
6I2H
5.8
-
?
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
312
Blastp_CBE
69.80
43%
-100
- C2 -
-
6ERT
5.7
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
158
Blastp_CBE
69.78
43%
-103
- C2 -
-
5LCU
5.5
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
319
Blastp_CBE
69.77
43%
-101
- C2 -
-
6EH3
5.2
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
357
Blastp_CBE
69.74
43%
-101
- C2 -
-
5N1M
4.0
-
KAPCA_CRIGR
A:
[33-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
144
Blastp_CBE
69.73
43%
-97
- C2 -
-
5N7P
4.4
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
353
Blastp_CBE
69.67
43%
-99
- C2 -
-
5N36
3.5
-
KAPCA_CRIGR
A:
[33-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
352
Blastp_CBE
69.67
43%
-99
- C2 -
-
5N37
4.8
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
166
Blastp_CBE
69.65
43%
-102
- C2 -
-
5UZK
9.0
-
KAPCA_HUMAN
A:
[33-330]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
148
Blastp_CBE
69.52
43%
-99
- C2 -
-
5N1D
4.9
-
KAPCA_CRIGR
A:
[33-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
316
Blastp_CBE
69.51
43%
-100
- C2 -
-
6EMA
6.4
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
354
Blastp_CBE
69.49
43%
-97
- C2 -
-
5N33
3.9
-
KAPCA_CRIGR
A:
[33-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
153
Blastp_CBE
69.45
43%
-99
- C2 -
-
5M6V
6.4
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
149
Blastp_CBE
69.44
43%
-97
- C2 -
-
5MHI
4.0
-
KAPCA_CRIGR
A:
[33-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
150
Blastp_CBE
69.41
43%
-102
- C2 -
-
5M75
5.9
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
179
Blastp_CBE
69.38
43%
-97
- C2 -
-
3OVV
6.6
-
KAPCA_HUMAN
A:
[33-330]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
174
Blastp_CBE
69.37
43%
-97
- C2 -
-
4UJ1
6.6
-
KAPCA_HUMAN
A:
[33-330]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
331
Blastp_CBE
69.35
43%
-101
- C2 -
-
5NTJ
3.8
-
KAPCA_CRIGR
A:
[35-335]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
159
Blastp_CBE
69.34
43%
-99
- C2 -
-
5LCT
5.5
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
363
Blastp_CBE
69.27
43%
-100
- C2 -
-
5NW8
5.5
-
KAPCA_CRIGR
A:
[33-330]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
185
Blastp_CBE
69.32
43%
-96
- C2 -
-
5BX6
4.2
-
KAPCA_HUMAN
A:
[33-330]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
330
Blastp_CBE
69.31
43%
-100
- C2 -
-
5O0E
6.6
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
347
Blastp_CBE
69.29
43%
-97
- C2 -
-
5N3D
3.7
-
KAPCA_CRIGR
A:
[33-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
298
Blastp_CBE
69.26
42%
-100
- C2 -
-
4YXR
4.3
-
KAPCA_BOVIN
A:
[34-329]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
D
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
283
Blastp_CBE
69.27
42%
-103
- C2 -
-
1SVG
9.5
-
KAPCA_BOVIN
A:
[34-329]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
259
Blastp_CBE
69.26
42%
-106
- C2 -
-
5VIB
7.9
-
KAPCA_BOVIN
A:
[35-350]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
----
D
T
S
N
F
D
-
D
---------------------------------------------
141
Blastp_CBE
69.22
43%
-101
- C2 -
-
4Z84
6.8
-
KAPCA_BOVIN
A:
[35-330]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
349
Blastp_CBE
69.21
43%
-100
- C2 -
-
5N3B
3.4
-
KAPCA_CRIGR
A:
[34-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
361
Blastp_CBE
69.16
43%
-100
- C2 -
-
5N1F
4.7
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
290
Blastp_CBE
69.18
42%
-105
- C2 -
-
1YDS
4.9
-
KAPCA_BOVIN
E:
[34-329]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
D
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
328
Blastp_CBE
69.19
43%
-98
- C2 -
-
5OK3
6.5
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
217
Blastp_CBE
69.18
43%
-115
- C2 -
-
4NTT
4.8
-
KAPCA_MOUSE
B:
[40-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
325
Blastp_CBE
69.14
43%
-99
- C2 -
-
5OTG
5.2
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
351
Blastp_CBE
69.13
43%
-100
- C2 -
-
5N39
4.8
-
KAPCA_CRIGR
A:
[33-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
348
Blastp_CBE
69.17
43%
-97
- C2 -
-
5N3C
3.8
-
KAPCA_CRIGR
A:
[34-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
358
Blastp_CBE
69.12
43%
-97
- C2 -
-
5N1L
5.9
-
KAPCA_CRIGR
A:
[33-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
323
Blastp_CBE
69.13
43%
-100
- C2 -
-
5OUC
5.0
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
263
Blastp_CBE
69.16
42%
-104
- C2 -
-
6E99
7.6
-
KAPCA_BOVIN
A:
[35-330]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
161
Blastp_CBE
69.14
43%
-97
- C2 -
-
5LCQ
5.6
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
268
Blastp_CBE
69.13
42%
-101
- C2 -
-
2C1B
6.7
-
KAPCA_BOVIN
A:
[35-330]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
317
Blastp_CBE
69.09
43%
-101
- C2 -
-
6EM6
6.8
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
151
Blastp_CBE
69.12
43%
-101
- C2 -
-
5M71
5.5
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
157
Blastp_CBE
69.11
43%
-96
- C2 -
-
5M0B
5.0
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
310
Blastp_CBE
69.08
43%
-102
- C2 -
-
6ERW
5.6
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
----
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
187
Blastp_CBE
69.10
43%
-98
- C2 -
-
3VQH
7.2
-
KAPCA_HUMAN
A:
[33-330]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
433
Blastp_CBE
69.01
42%
-108
- C2 -
-
4C34
9.4
-
KAPCA_BOVIN
A:
[35-330]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
Y
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
------
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
178
Blastp_CBE
69.09
43%
-96
- C2 -
-
3OWP
5.9
-
KAPCA_HUMAN
A:
[33-330]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
180
Blastp_CBE
69.08
43%
-103
- C2 -
-
3OOG
4.5
-
KAPCA_HUMAN
A:
[33-330]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
341
Blastp_CBE
69.07
43%
-97
- C2 -
-
5N3J
4.6
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
184
Blastp_CBE
69.05
43%
-96
- C2 -
-
5BX7
4.2
-
KAPCA_HUMAN
A:
[33-330]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
420
Blastp_CBE
68.94
42%
-101
- C2 -
-
1XH7
9.4
-
KAPCA_BOVIN
A:
[34-329]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
326
Blastp_CBE
68.98
43%
-100
- C2 -
-
5OT3
6.3
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
152
Blastp_CBE
69.01
43%
-95
- C2 -
-
5M6Y
5.9
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
389
Blastp_CBE
68.94
43%
-103
- C2 -
-
4IB3
7.0
-
KAPCA_MOUSE
A:
[46-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
224
Blastp_CBE
69.00
43%
-103
- C2 -
-
2F7E
7.5
-
KAPCA_BOVIN
E:
[35-330]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
---
T
-
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
423
Blastp_CBE
68.92
42%
-101
- C2 -
-
1XH4
9.2
-
KAPCA_BOVIN
A:
[34-329]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
147
Blastp_CBE
68.99
43%
-95
- C2 -
-
5N1E
4.1
-
KAPCA_CRIGR
A:
[32-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
297
Blastp_CBE
68.98
42%
-101
- C2 -
-
4YXS
5.8
-
KAPCA_BOVIN
A:
[34-329]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
D
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
371
Blastp_CBE
68.90
43%
-104
- C2 -
-
4HPU
7.5
-
KAPCA_MOUSE
E:
[40-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
129
Blastp_CBE
68.95
44%
-97
- C2 -
-
4AXA
8.2
-
KAPCA_BOVIN
A:
[35-330]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
267
Blastp_CBE
68.94
42%
-103
- C2 -
-
2VO7
8.3
-
KAPCA_BOVIN
A:
[35-330]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
257
Blastp_CBE
68.92
42%
-102
- C2 -
-
1XH5
9.0
-
KAPCA_BOVIN
A:
[34-329]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
313
Blastp_CBE
68.90
43%
-99
- C2 -
-
6ERS
6.1
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
---
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
305
Blastp_CBE
68.90
43%
-101
- C2 -
-
6I2D
6.1
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
209
Blastp_CBE
68.92
43%
-109
- C2 -
-
6MM8
3.1
-
KAPCA_MOUSE
C:
[29-338]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
142
Blastp_CBE
68.90
43%
-100
- C2 -
-
6F14
4.7
-
KAPCA_CRIGR
A:
[33-330]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
-----
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
199
Blastp_CBE
68.89
43%
-108
- C2 -
-
1REJ
6.7
-
KAPCA_MOUSE
A:
[40-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
235
Blastp_CBE
68.85
43%
-106
- C2 -
-
2UZT
7.5
-
KAPCA_BOVIN
A:
[20-315]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
---
T
-
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
D
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
306
Blastp_CBE
68.81
43%
-98
- C2 -
-
6I2C
6.1
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
---
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
418
Blastp_CBE
68.83
42%
-100
- C2 -
-
3ZO1
6.2
-
KAPCA_BOVIN
A:
[35-330]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
398
Blastp_CBE
68.76
43%
-103
- C2 -
-
4IAC
7.0
-
KAPCA_MOUSE
A:
[46-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
367
Blastp_CBE
68.77
43%
-96
- C2 -
-
4WB5
8.8
-
KAPCA_HUMAN
A:
[32-329]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
160
Blastp_CBE
68.82
43%
-97
- C2 -
-
5LCR
4.9
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
359
Blastp_CBE
68.77
43%
-98
- C2 -
-
5N1H
4.8
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
130
Blastp_CBE
68.81
44%
-97
- C2 -
-
2UW7
7.5
-
KAPCA_BOVIN
A:
[35-330]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
300
Blastp_CBE
68.80
42%
-100
- C2 -
-
3DND
4.5
-
KAPCA_BOVIN
A:
[34-329]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
D
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
405
Blastp_CBE
68.72
43%
-101
- C2 -
-
3X2U
6.7
-
KAPCA_MOUSE
A:
[47-336]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
424
Blastp_CBE
68.70
42%
-104
- C2 -
-
1Q8W
5.6
-
KAPCA_BOVIN
A:
[34-329]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
432
Blastp_CBE
68.69
42%
-107
- C2 -
-
4C35
6.6
-
KAPCA_BOVIN
A:
[35-330]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
Y
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
139
Blastp_CBE
68.77
43%
-98
- C2 -
-
4Z83
8.1
-
KAPCA_BOVIN
E:
[34-329]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
314
Blastp_CBE
68.73
43%
-99
- C2 -
-
6EMD
6.3
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
327
Blastp_CBE
68.76
43%
-98
- C2 -
-
5OL3
6.3
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
343
Blastp_CBE
68.75
43%
-98
- C2 -
-
5N3H
4.1
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
375
Blastp_CBE
68.74
43%
-104
- C2 -
-
4DH3
8.0
-
KAPCA_MOUSE
A:
[40-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
336
Blastp_CBE
68.70
43%
-99
- C2 -
-
5N3P
4.6
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
394
Blastp_CBE
68.67
43%
-103
- C2 -
-
4IAK
7.3
-
KAPCA_MOUSE
A:
[46-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
409
Blastp_CBE
68.66
43%
-101
- C2 -
-
4DG3
8.1
-
KAPCA_MOUSE
E:
[61-350]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
136
Blastp_CBE
68.73
44%
-104
- C2 -
-
1SMH
3.2
-
KAPCA_BOVIN
A:
[34-329]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
E
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
L
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
173
Blastp_CBE
68.72
43%
-97
- C2 -
-
4UJ2
6.6
-
KAPCA_HUMAN
A:
[33-330]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
220
Blastp_CBE
68.71
43%
-103
- C2 -
-
2OJF
6.8
-
KAPCA_BOVIN
E:
[35-330]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
---
T
-
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
154
Blastp_CBE
68.70
43%
-100
- C2 -
-
5M0U
Error
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
-----
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
397
Blastp_CBE
68.69
43%
-101
- C2 -
-
4IAD
7.7
-
KAPCA_MOUSE
A:
[46-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
337
Blastp_CBE
68.68
43%
-101
- C2 -
-
5N3O
4.9
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
146
Blastp_CBE
68.67
43%
-95
- C2 -
-
5N1K
3.3
-
KAPCA_CRIGR
A:
[33-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
----
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
287
Blastp_CBE
68.66
42%
-100
- C2 -
-
1Q8T
4.4
-
KAPCA_BOVIN
A:
[34-329]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
338
Blastp_CBE
68.61
43%
-97
- C2 -
-
5N3M
2.4
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
345
Blastp_CBE
68.59
43%
-99
- C2 -
-
5N3F
3.8
-
KAPCA_CRIGR
A:
[32-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
--
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
-
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
362
Blastp_CBE
68.52
43%
-96
- C2 -
-
6EM7
8.7
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
309
Blastp_CBE
68.61
43%
-94
- C2 -
-
6ESA
7.2
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
339
Blastp_CBE
68.60
43%
-98
- C2 -
-
5N3L
5.1
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
265
Blastp_CBE
68.57
42%
-100
- C2 -
-
3ZO4
7.7
-
KAPCA_BOVIN
A:
[35-330]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
216
Blastp_CBE
68.59
43%
-109
- C2 -
-
2ERZ
5.2
-
KAPCA_MOUSE
E:
[41-330]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
256
Blastp_CBE
68.57
42%
-102
- C2 -
-
1XH6
8.7
-
KAPCA_BOVIN
A:
[34-329]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
340
Blastp_CBE
68.54
43%
-98
- C2 -
-
5N3K
3.9
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
191
Blastp_CBE
68.58
43%
-103
- C2 -
-
4HPT
5.8
-
KAPCA_MOUSE
E:
[40-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
419
Blastp_CBE
68.50
42%
-97
- C2 -
-
2JDS
7.5
-
KAPCA_BOVIN
A:
[35-330]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
218
Blastp_CBE
68.56
43%
-116
- C2 -
-
4NTT
4.5
-
KAPCA_MOUSE
A:
[40-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
121
Blastp_CBE
68.56
44%
-101
- C2 -
-
3L9N
7.8
-
KAPCA_HUMAN
A:
[33-330]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
--------
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
379
Blastp_CBE
68.55
43%
-102
- C2 -
-
2QCS
9.1
-
KAPCA_MOUSE
A:
[40-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
269
Blastp_CBE
68.54
42%
-102
- C2 -
-
2C1A
6.7
-
KAPCA_BOVIN
A:
[35-330]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
369
Blastp_CBE
68.53
43%
-102
- C2 -
-
5JR7
5.3
-
KAPCA_MOUSE
A:
[40-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
299
Blastp_CBE
68.52
42%
-100
- C2 -
-
3DNE
5.9
-
KAPCA_BOVIN
A:
[34-329]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
D
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
360
Blastp_CBE
68.46
43%
-95
- C2 -
-
5N1G
2.8
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
370
Blastp_CBE
68.45
43%
-105
- C2 -
-
4WBB
5.6
-
KAPCA_MOUSE
B:
[40-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
320
Blastp_CBE
68.50
43%
-106
- C2 -
-
6EH2
5.4
-
KAPCA_CRIGR
A:
[35-335]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
----
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
--
G
D
T
S
N
F
D
-
D
---------------------------------------------
232
Blastp_CBE
68.49
43%
-102
- C2 -
-
2UZW
5.5
-
KAPCA_BOVIN
E:
[20-315]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
---
T
-
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
D
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
182
Blastp_CBE
68.48
43%
-100
- C2 -
-
3L9L
8.0
-
KAPCA_HUMAN
A:
[33-330]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
413
Blastp_CBE
68.40
43%
-97
- C2 -
-
4WB7
9.0
-
DNJB1_HUMAN (first)
A:
[87-384]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
407
Blastp_CBE
68.40
42%
-101
- C2 -
-
2GNH
5.7
-
KAPCA_BOVIN
A:
[34-329]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
I
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
134
Blastp_CBE
68.47
44%
-97
- C2 -
-
2JDT
6.7
-
KAPCA_BOVIN
A:
[35-330]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
237
Blastp_CBE
68.46
43%
-103
- C2 -
-
1CDK
8.4
-
KAPCA_PIG
A:
[34-329]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
F
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
Y
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
D
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
255
Blastp_CBE
68.45
42%
-101
- C2 -
-
1XH8
10.2
-
KAPCA_BOVIN
A:
[34-329]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
387
Blastp_CBE
68.39
43%
-101
- C2 -
-
4XW5
7.6
-
KAPCA_MOUSE
A:
[46-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
197
Blastp_CBE
68.43
43%
-101
- C2 -
-
3FJQ
9.6
-
KAPCA_MOUSE
E:
[40-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
181
Blastp_CBE
68.43
43%
-97
- C2 -
-
3L9L
8.1
-
KAPCA_HUMAN
B:
[33-330]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
248
Blastp_CBE
68.40
44%
-99
- C2 -
-
2UW0
8.9
-
KAPCA_BOVIN
A:
[35-330]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
416
Blastp_CBE
68.34
42%
-104
- C2 -
-
5VHB
7.5
-
KAPCA_BOVIN
A:
[35-330]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
------------
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
318
Blastp_CBE
68.41
43%
-100
- C2 -
-
6EM2
5.4
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
175
Blastp_CBE
68.40
43%
-99
- C2 -
-
3POO
7.6
-
KAPCA_HUMAN
A:
[33-330]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
----
D
T
S
N
F
D
-
D
---------------------------------------------
186
Blastp_CBE
68.39
43%
-93
- C2 -
-
4UJB
6.9
-
KAPCA_HUMAN
A:
[33-330]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
177
Blastp_CBE
68.39
43%
-100
- C2 -
-
3OXT
6.4
-
KAPCA_HUMAN
A:
[33-330]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
390
Blastp_CBE
68.32
43%
-101
- C2 -
-
4IB1
8.0
-
KAPCA_MOUSE
A:
[46-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
242
Blastp_CBE
68.38
44%
-100
- C2 -
-
2VNY
6.1
-
KAPCA_BOVIN
A:
[35-330]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
253
Blastp_CBE
68.36
42%
-106
- C2 -
-
4IJ9
7.5
-
KAPCA_BOVIN
A:
[34-329]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
251
Blastp_CBE
68.37
43%
-104
- C2 -
-
3QAL
9.3
-
KAPCA_MOUSE
E:
[40-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
A
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
214
Blastp_CBE
68.36
43%
-102
- C2 -
-
6MM5
2.8
-
KAPCA_MOUSE
E:
[29-318]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
176
Blastp_CBE
68.35
43%
-98
- C2 -
-
3P0M
6.6
-
KAPCA_HUMAN
A:
[33-330]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
204
Blastp_CBE
68.34
43%
-107
- C2 -
-
1FMO
6.1
-
KAPCA_MOUSE
E:
[40-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
124
Blastp_CBE
68.33
44%
-100
- C2 -
-
1XH9
10.0
-
KAPCA_BOVIN
A:
[34-329]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
E
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
L
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
200
Blastp_CBE
68.32
43%
-105
- C2 -
-
1RE8
7.7
-
KAPCA_MOUSE
A:
[40-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
282
Blastp_CBE
68.30
42%
-101
- C2 -
-
1VEB
7.9
-
KAPCA_BOVIN
A:
[34-329]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
262
Blastp_CBE
68.27
42%
-100
- C2 -
-
6E9L
7.4
-
KAPCA_BOVIN
A:
[35-330]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
195
Blastp_CBE
68.27
43%
-105
- C2 -
-
3IDC
6.8
-
KAPCA_MOUSE
A:
[40-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
402
Blastp_CBE
68.19
42%
-101
- C2 -
-
2GNF
4.9
-
KAPCA_BOVIN
A:
[34-329]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
I
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
289
Blastp_CBE
68.24
42%
-102
- C2 -
-
1YDT
6.8
-
KAPCA_BOVIN
E:
[34-329]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
D
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
302
Blastp_CBE
68.21
42%
-100
- C2 -
-
2GNJ
5.3
-
KAPCA_BOVIN
A:
[34-329]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
I
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
373
Blastp_CBE
68.23
43%
-103
- C2 -
-
4DH7
9.2
-
KAPCA_MOUSE
A:
[40-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
286
Blastp_CBE
68.22
42%
-99
- C2 -
-
1Q8U
5.9
-
KAPCA_BOVIN
A:
[34-329]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
133
Blastp_CBE
68.21
44%
-102
- C2 -
-
2JDV
9.2
-
KAPCA_BOVIN
A:
[35-330]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
392
Blastp_CBE
68.14
43%
-102
- C2 -
-
4IAZ
7.3
-
KAPCA_MOUSE
A:
[46-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
393
Blastp_CBE
68.19
43%
-103
- C2 -
-
4IAY
6.4
-
KAPCA_MOUSE
A:
[46-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
380
Blastp_CBE
68.13
43%
-105
- C2 -
-
3TNQ
5.6
-
KAPCA_MOUSE
B:
[40-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
376
Blastp_CBE
68.18
43%
-106
- C2 -
-
4DH1
7.6
-
KAPCA_MOUSE
A:
[40-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
364
Blastp_CBE
68.17
43%
-96
- C2 -
-
4WB8
8.5
-
KAPCA_HUMAN
A:
[19-316]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
223
Blastp_CBE
68.16
43%
-100
- C2 -
-
2F7X
7.1
-
KAPCA_BOVIN
E:
[35-330]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
---
T
-
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
190
Blastp_CBE
68.14
43%
-98
- C2 -
-
6C0U
8.3
-
KAPCA_HUMAN
A:
[36-333]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
245
Blastp_CBE
68.12
44%
-99
- C2 -
-
2UW6
5.9
-
KAPCA_BOVIN
A:
[35-330]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
228
Blastp_CBE
68.12
43%
-91
- C2 -
-
3MVJ
5.6
-
KAPCA_HUMAN
A:
[53-350]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
196
Blastp_CBE
68.13
43%
-102
- C2 -
-
3IDB
7.5
-
KAPCA_MOUSE
A:
[40-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
225
Blastp_CBE
68.12
43%
-102
- C2 -
-
2GU8
7.4
-
KAPCA_HUMAN
A:
[27-316]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
E
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
243
Blastp_CBE
68.10
44%
-96
- C2 -
-
2VNW
6.2
-
KAPCA_BOVIN
A:
[35-330]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
383
Blastp_CBE
68.11
43%
-106
- C2 -
-
4O21
7.0
-
KAPCA_MOUSE
A:
[32-321]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
417
Blastp_CBE
68.03
42%
-100
- C2 -
-
3ZO3
7.2
-
KAPCA_BOVIN
A:
[35-330]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
240
Blastp_CBE
68.10
44%
-97
- C2 -
-
2VO6
8.2
-
KAPCA_BOVIN
A:
[35-330]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
381
Blastp_CBE
68.08
43%
-100
- C2 -
-
1L3R
7.0
-
KAPCA_MOUSE
E:
[40-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
198
Blastp_CBE
68.07
43%
-110
- C2 -
-
1REK
10.2
-
KAPCA_MOUSE
A:
[40-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
404
Blastp_CBE
68.06
43%
-101
- C2 -
-
3X2V
7.9
-
KAPCA_MOUSE
A:
[47-336]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
385
Blastp_CBE
68.05
43%
-100
- C2 -
-
6E21
7.3
-
KAPCA_MOUSE
A:
[46-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
374
Blastp_CBE
67.99
43%
-101
- C2 -
-
4DH5
7.4
-
KAPCA_MOUSE
A:
[40-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
372
Blastp_CBE
67.99
43%
-101
- C2 -
-
4DH8
9.0
-
KAPCA_MOUSE
A:
[40-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
415
Blastp_CBE
68.03
42%
-101
- C2 -
-
3ZO2
6.3
-
KAPCA_BOVIN
A:
[35-330]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
333
Blastp_CBE
67.99
43%
-97
- C2 -
-
5N3S
4.0
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
307
Blastp_CBE
68.02
43%
-99
- C2 -
-
6I2B
6.3
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
--
G
D
T
S
N
F
D
-
D
---------------------------------------------
156
Blastp_CBE
68.01
43%
-95
- C2 -
-
5M0C
4.4
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
189
Blastp_CBE
68.00
43%
-94
- C2 -
-
3AGL
9.2
-
KAPCA_HUMAN
A:
[33-330]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
171
Blastp_CBE
67.99
43%
-95
- C2 -
-
4UJA
7.2
-
KAPCA_HUMAN
A:
[33-330]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
250
Blastp_CBE
67.97
44%
-99
- C2 -
-
2UVY
7.0
-
KAPCA_BOVIN
A:
[35-330]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
344
Blastp_CBE
67.92
43%
-97
- C2 -
-
5N3G
4.1
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
122
Blastp_CBE
67.95
44%
-100
- C2 -
-
3L9M
8.0
-
KAPCA_HUMAN
B:
[33-330]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
241
Blastp_CBE
67.94
44%
-98
- C2 -
-
2VO3
8.0
-
KAPCA_BOVIN
A:
[35-330]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
183
Blastp_CBE
67.93
43%
-97
- C2 -
-
3AGM
8.5
-
KAPCA_HUMAN
A:
[33-330]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
429
Blastp_CBE
67.84
42%
-99
- C2 -
-
4C37
6.7
-
KAPCA_BOVIN
A:
[35-330]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
Y
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
291
Blastp_CBE
67.92
42%
-101
- C2 -
-
1YDR
5.1
-
KAPCA_BOVIN
E:
[34-329]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
D
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
335
Blastp_CBE
67.90
43%
-98
- C2 -
-
5N3Q
4.1
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
421
Blastp_CBE
67.82
42%
-100
- C2 -
-
3KKV
7.6
-
KAPCA_BOVIN
A:
[34-329]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
378
Blastp_CBE
67.89
43%
-103
- C2 -
-
4DG0
6.7
-
KAPCA_MOUSE
E:
[40-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
399
Blastp_CBE
67.88
43%
-101
- C2 -
-
4X6R
7.9
-
KAPCA_MOUSE
A:
[40-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
206
Blastp_CBE
67.86
43%
-107
- C2 -
-
2QUR
5.2
-
KAPCA_MOUSE
A:
[40-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
P
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
A
D
-
D
---------------------------------------------
428
Blastp_CBE
67.77
42%
-101
- C2 -
-
4C38
6.2
-
KAPCA_BOVIN
A:
[35-330]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
Y
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
261
Blastp_CBE
67.83
43%
-99
- C2 -
-
1RDQ
8.4
-
KAPCA_MOUSE
E:
[40-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
A
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
222
Blastp_CBE
67.84
43%
-110
- C2 -
-
2F7Z
7.6
-
KAPCA_BOVIN
E:
[35-330]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
---
T
-
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
188
Blastp_CBE
67.83
43%
-93
- C2 -
-
3AGL
9.4
-
KAPCA_HUMAN
B:
[33-330]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
234
Blastp_CBE
67.82
43%
-100
- C2 -
-
2UZU
6.1
-
KAPCA_BOVIN
E:
[20-315]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
---
T
-
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
D
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
193
Blastp_CBE
67.81
43%
-102
- C2 -
-
3OW3
4.1
-
KAPCA_MOUSE
A:
[40-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
128
Blastp_CBE
67.81
44%
-94
- C2 -
-
2VO0
7.9
-
KAPCA_BOVIN
A:
[35-330]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
249
Blastp_CBE
67.79
44%
-100
- C2 -
-
2UVZ
7.7
-
KAPCA_BOVIN
A:
[35-330]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
135
Blastp_CBE
67.77
44%
-97
- C2 -
-
1XHA
10.0
-
KAPCA_BOVIN
A:
[34-329]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
E
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
L
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
414
Blastp_CBE
67.75
43%
-95
- C2 -
-
4WB6
8.6
-
KAPCA_HUMAN
A:
[32-329]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
R
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
215
Blastp_CBE
67.73
43%
-104
- C2 -
-
3O7L
5.8
-
KAPCA_MOUSE
B:
[40-333]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
----
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
I
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
I
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
301
Blastp_CBE
67.70
42%
-100
- C2 -
-
2GNL
5.3
-
KAPCA_BOVIN
A:
[34-329]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
I
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
221
Blastp_CBE
67.69
43%
-103
- C2 -
-
2OH0
7.3
-
KAPCA_BOVIN
E:
[35-330]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
---
T
-
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
386
Blastp_CBE
67.68
43%
-102
- C2 -
-
4XW6
7.5
-
KAPCA_MOUSE
A:
[46-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
226
Blastp_CBE
67.64
43%
-98
- C2 -
-
3MVJ
5.4
-
KAPCA_HUMAN
E:
[53-350]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
131
Blastp_CBE
67.65
44%
-98
- C2 -
-
2UW4
5.5
-
KAPCA_BOVIN
A:
[35-330]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
-
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
329
Blastp_CBE
67.61
43%
-98
- C2 -
-
5O5M
6.5
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
--
G
D
T
S
N
F
D
-
D
---------------------------------------------
210
Blastp_CBE
67.64
43%
-102
- C2 -
-
6MM7
2.7
-
KAPCA_MOUSE
D:
[29-330]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
412
Blastp_CBE
67.63
43%
-93
- C2 -
-
4WB7
8.6
-
KAPCA_HUMAN
B:
[87-384]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
236
Blastp_CBE
67.61
43%
-100
- C2 -
-
1CDK
9.1
-
KAPCA_PIG
B:
[34-329]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
F
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
Y
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
D
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
391
Blastp_CBE
67.54
43%
-102
- C2 -
-
4IB0
7.9
-
KAPCA_MOUSE
A:
[46-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
205
Blastp_CBE
67.58
43%
-103
- C2 -
-
1ATP
9.1
-
KAPCA_MOUSE
E:
[40-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
202
Blastp_CBE
67.56
43%
-102
- C2 -
-
1Q24
8.6
-
KAPCA_BOVIN
A:
[34-329]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
123
Blastp_CBE
67.56
44%
-100
- C2 -
-
3L9M
7.8
-
KAPCA_HUMAN
A:
[33-330]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
233
Blastp_CBE
67.55
43%
-98
- C2 -
-
2UZV
7.5
-
KAPCA_BOVIN
A:
[20-315]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
---
T
-
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
D
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
403
Blastp_CBE
67.48
43%
-103
- C2 -
-
3X2W
7.7
-
KAPCA_MOUSE
A:
[47-336]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
247
Blastp_CBE
67.54
44%
-95
- C2 -
-
2UW3
5.2
-
KAPCA_BOVIN
A:
[35-330]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
422
Blastp_CBE
67.50
42%
-97
- C2 -
-
3BWJ
10.4
-
KAPCA_BOVIN
A:
[34-329]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
285
Blastp_CBE
67.48
42%
-102
- C2 -
-
1STC
8.5
-
KAPCA_BOVIN
E:
[34-329]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
396
Blastp_CBE
67.45
43%
-100
- C2 -
-
4IAF
7.8
-
KAPCA_MOUSE
A:
[46-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
431
Blastp_CBE
67.44
42%
-99
- C2 -
-
4C36
6.0
-
KAPCA_BOVIN
A:
[35-330]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
Y
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
395
Blastp_CBE
67.36
43%
-98
- C2 -
-
4IAI
8.2
-
KAPCA_MOUSE
A:
[46-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
246
Blastp_CBE
67.36
44%
-97
- C2 -
-
2UW5
6.9
-
KAPCA_BOVIN
A:
[35-330]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
244
Blastp_CBE
67.33
44%
-97
- C2 -
-
2UW8
4.5
-
KAPCA_BOVIN
A:
[35-330]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
252
Blastp_CBE
67.31
43%
-94
- C2 -
-
4WB6
9.1
-
KAPCA_HUMAN
B:
[32-329]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
R
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
165
Blastp_CBE
67.25
43%
-98
- C2 -
-
1JBP
5.9
-
KAPCA_MOUSE
E:
[40-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
E
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
212
Blastp_CBE
67.23
43%
-104
- C2 -
-
6MM6
3.3
-
KAPCA_MOUSE
E:
[29-338]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
388
Blastp_CBE
67.16
43%
-97
- C2 -
-
4XW4
7.3
-
KAPCA_MOUSE
A:
[46-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
294
Blastp_CBE
67.16
43%
-99
- C2 -
-
3NX8
2.4
-
KAPCA_HUMAN
A:
[33-330]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
L
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
321
Blastp_CBE
67.08
43%
-97
- C2 -
-
6EGW
6.2
-
KAPCA_CRIGR
A:
[35-332]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
---
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
-
G
D
T
S
N
F
D
-
D
---------------------------------------------
266
Blastp_CBE
67.08
42%
-102
- C2 -
-
3AG9
8.1
-
KAPCA_BOVIN
B:
[35-350]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
132
Blastp_CBE
67.08
44%
-99
- C2 -
-
2UVX
4.4
-
KAPCA_BOVIN
A:
[35-330]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
401
Blastp_CBE
67.07
43%
-100
- C2 -
-
4DFX
7.9
-
KAPCA_MOUSE
E:
[40-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
406
Blastp_CBE
67.02
42%
-97
- C2 -
-
2GNI
5.9
-
KAPCA_BOVIN
A:
[34-329]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
I
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
260
Blastp_CBE
66.98
42%
-103
- C2 -
-
5VI9
6.8
-
KAPCA_BOVIN
A:
[35-351]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
------
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
-
D
T
S
N
F
------------------------------------------------
427
Blastp_CBE
66.94
42%
-98
- C2 -
-
6FRX
8.3
-
KAPCA_HUMAN
A:
[33-330]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
R
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
Q
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
-----
S
N
F
D
-
D
---------------------------------------------
368
Blastp_CBE
66.87
43%
-99
- C2 -
-
5JR7
5.8
-
KAPCA_MOUSE
C:
[40-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
293
Blastp_CBE
66.85
42%
-101
- C2 -
-
3AMA
7.6
-
KAPCA_HUMAN
A:
[33-330]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
R
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
Q
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
-----
S
N
F
D
-
D
---------------------------------------------
239
Blastp_CBE
66.77
43%
-99
- C2 -
-
3QAM
8.0
-
KAPCA_MOUSE
E:
[40-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
A
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
384
Blastp_CBE
66.72
43%
-104
- C2 -
-
3PVB
7.6
-
KAPCA_MOUSE
A:
[35-324]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
434
Blastp_CBE
66.60
42%
-101
- C2 -
-
5N23
7.2
-
KAPCA_HUMAN
A:
[33-331]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
R
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
Q
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
-
P
--
W
-
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
------
S
N
F
D
-
D
---------------------------------------------
207
Blastp_CBE
66.66
43%
-105
- C2 -
-
1BX6
7.1
-
KAPCA_MOUSE
A:
[40-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
192
Blastp_CBE
66.62
43%
-101
- C2 -
-
4DIN
7.5
-
KAPCA_MOUSE
A:
[40-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
208
Blastp_CBE
66.60
43%
-102
- C2 -
-
1BKX
5.6
-
KAPCA_MOUSE
A:
[40-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
288
Blastp_CBE
66.50
43%
-103
- C2 -
-
3FHI
9.7
-
KAPCA_MOUSE
A:
[40-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
A
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
---------------------------------------------
292
Blastp_CBE
66.17
42%
-98
- C2 -
-
3AMB
7.8
-
KAPCA_HUMAN
A:
[33-330]
------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
R
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
Q
-
Q
---
A
V
---
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
K
--
R
--
V
K
G
-
R
T
W
T
----
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
-----
S
N
F
D
-
D
---------------------------------------------
572
HHSearch
64.38
45%
-35
- C2 -
-
4RA5
6.7
-
KPCT_HUMAN
A:
[2-328]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
I
E
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
F
---
K
K
---
T
-
N
----
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
--
M
-
D
D
D
V
E
C
T
M
V
E
K
R
V
L
-
S
L--
A
W
---
E
-
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
--
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
-
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
K
--
E
N
M
L
G
D
-
A
K
T
N
--
E
-
F
-
C
--
G
T
P
D
Y
I
A
P
E
I
L
L
G
-----
Q
---
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
-
Q
S
P
F
-----
H
--
G
---
Q
D
E
----
E
---
E
L
F
H
S
I
--
R
--
M
D
N
P
--
F
Y
P
-----
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
G
V
------------
R
-
G
D
-
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
--
P
-----
K
V
K
S
P
F
D
C
S
N
F
D
-
K
E
F
L
N
E
K
P
R
L
S
F
A
D
R
A
----
L
I
N
S
M
D
Q
N
M
---
F
R
--
N
F
S
F
M
N
P
G
M
-
555
Fugue
64.35
35%
-29
- C2 -
-
4AW2
2.2
-
MRCKA_RAT
A:
[1-416]
---------------
S
G
E
V
R
L
R
Q
L
E
Q
F
I
L
D
-
G
--------------
P
A
Q
T
N
G
Q
C
F
S
--------------------
V
E
T
L
L
D
I
L
I
C
L
Y
D
E
C
N
N
S
P
L
R
R
E
-------------------
K
N
I
L
E
Y
L
E
W
A
K
P
F
T
S
K
V
K
Q
M
-----------
R
L
H
R
E
D
F
E
I
L
K
V
I
G
R
G
-
A
F
G
E
V
A
V
V
K
L
---
K
N
---
A
-
D
----
K
V
F
A
M
K
I
L
N
K
W
E
M
L
--
K
-
R
A
E
T
A
C
F
R
E
E
R
D
V
L
-
V
---
N
G
---
D
-
S
K
W
I
T
T
L
H
Y
A
F
Q
D
D
N
N
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F-
E
D
R
L
P
E
E
M
A
R
F
Y
L
A
E
M
V
I
A
I
D
S
V
H
Q
-
L
-
H
Y
V
H
R
D
I
K
P
D
N
I
L
M
D
-
M
N
G
H
I
R
L
A
D
F
G
S
C
L
--
K
L
M
E
D
G
-
T
V
Q
S
--
S
-
V
A
V
--
G
T
P
D
Y
I
S
P
E
I
L
Q
A
-----
M
---
E
GGKGR
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
-
E
T
P
F
-----
Y
--
A
---
E
S
L
----
V
---
E
T
Y
G
K
I
--
M
--
N
H
K
E
--
R
F
Q
FPTQV
T
D
V
S
E
N
A
K
D
L
I
R
R
L
I
C
-
S
R
E
H
--
R
L
G
---------
Q
-
N
G
I
-
E
D
-
F
K
K
H
P
F
F
S
G
I
D
---
W
D
N
I
R
N
C
E
--
A
P
Y
I
--
P
-----
E
V
S
S
P
T
D
T
S
N
F
D
------------------------
V
D
S
G
H
H
---
L
P
FV
G
F
T
Y
T
S
S
C
V
L
586
HHSearch
63.99
47%
-37
- C2 -
-
5LI1
7.1
-
KPCI_HUMAN
A:
[7-346]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
---
K
K
---
T
-
D
----
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
--
D
-
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
-
E
---
Q
A
S--
N
-
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
--
E
G
L
R
P
G
-
D
T
T
S
--
T
-
F
-
C
--
G
T
P
N
Y
I
A
P
E
I
L
R
G
-----
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
-----
D
--
I
-----------TED
Y
L
F
Q
V
I
--
L
--
E
K
Q
I
--
R
I
P
-----
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
------
H
-
P
Q
T
G
F
-
A
D
-
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
--
P
-----
N
I
S
G
E
F
G
L
D
N
F
D
-
S
Q
F
T
N
E
P
V
Q
L
T
P
D
D
D
D
-
I
---
V
R
K
I
D
Q
S
E
---
F
E
--
G
F
E
Y
I
N
P
L
--
584
HHSearch
63.80
47%
-32
- C2 -
-
5LI9
6.8
-
KPCI_HUMAN
A:
[3-342]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
---
K
K
---
T
-
D
----
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
--
D
-
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
-
E
---
Q
A
S--
N
-
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
--
E
G
L
R
P
G
-
D
T
T
S
--
T
-
F
-
C
--
G
T
P
N
Y
I
A
P
E
I
L
R
G
-----
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
--------------------TED
Y
L
F
Q
V
I
--
L
--
E
K
Q
I
--
R
I
P
-----
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
------
H
-
P
Q
T
G
F
-
A
D
-
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
--
P
-----
N
I
S
G
E
F
G
L
D
N
F
D
-
S
Q
F
T
N
E
P
V
Q
L
T
P
D
D
D
D
----
I
V
R
K
I
D
Q
S
E
---
F
E
--
G
F
E
Y
I
N
P
L
--
99
Blastp_CBE
63.56
47%
-43
- C2 -
-
4Q9Z
6.0
-
KPCT_HUMAN
A:
[2-298]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
I
E
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
F
---
K
K
---
T
-
N
----
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
--
M
-
D
D
D
V
E
C
T
M
V
E
K
R
V
L
-
S
---
L
A
W--
E
-
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
--
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
-
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
K
--
E
N
M
L
G
D
-
A
K
T
N
--
E
-
F
-
C
--
G
T
P
D
Y
I
A
P
E
I
L
L
G
-----
Q
---
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
-
Q
S
P
F
-----
H
--
G
---
Q
D
E
----
E
---
E
L
F
H
S
I
--
R
--
M
D
N
P
--
F
Y
P
-----
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
G
V
------------
R
-
G
D
-
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
--
P
-----
K
V
K
S
P
F
D
C
S
N
F
D
-
K
E
F
L
N
E
----------------------------------------
97
Blastp_CBE
63.22
47%
-43
- C2 -
-
4RA5
6.7
-
KPCT_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
L
K
I
E
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
F
---
K
K
---
T
-
N
----
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
--
M
-
D
D
D
V
E
C
T
M
V
E
K
R
V
L
-
S
---
L
A
W--
E
-
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
--
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
-
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
K
--
E
N
M
L
G
D
-
A
K
T
N
--
E
-
F
-
C
--
G
T
P
D
Y
I
A
P
E
I
L
L
G
-----
Q
---
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
-
Q
S
P
F
-----
H
--
G
---
Q
D
E
----
E
---
E
L
F
H
S
I
--
R
--
M
D
N
P
--
F
Y
P
-----
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
G
V
------------
R
-
G
D
-
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
--
P
-----
K
V
K
S
P
F
D
C
S
N
F
D
-
K
E
F
L
N
E
----------------------------------------
550
Blastp_CBE
62.92
39%
-118
- C2 -
-
5LVP
5.5
-
PDPK1_HUMAN
C:
[33-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
-
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
S
----------
N
-
F
-
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
-----
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
N
E
----
G
---
L
I
F
A
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
-
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
--
P
P
---------------------------------------------------------------------
500
Blastp_CBE
62.93
36%
-115
- C2 -
-
3H9O
7.2
-
PDPK1_HUMAN
A:
[27-308]
----------------------------------------------------------------------------------------------------------------------------------------------------
R
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
-
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
S
----------
N
-
F
-
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
-----
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
N
E
----
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
-
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
--
P
P
---------------------------------------------------------------------
521
Blastp_CBE
62.92
39%
-118
- C2 -
-
3QD3
9.0
-
PDPK1_HUMAN
A:
[34-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
-
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
S
----------
N
-
F
-
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
-----
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
N
E
----
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
-
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
--
P
P
---------------------------------------------------------------------
474
Blastp_CBE
62.91
39%
-118
- C2 -
-
2PE2
2.9
-
PDPK1_HUMAN
A:
[8-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
-
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
S
------------
F
-
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
-----
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
N
E
----
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
-
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
--
P
P
---------------------------------------------------------------------
519
Blastp_CBE
62.89
39%
-115
* C2 *
-
3RWP
8.4
-
PDPK1_HUMAN
A:
[33-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
-
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
S
----------
N
-
F
-
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
-----
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
N
E
----
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
-
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
--
P
P
---------------------------------------------------------------------
524
Blastp_CBE
62.78
39%
-117
- C2 -
-
3QCX
6.9
-
PDPK1_HUMAN
A:
[34-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
-
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
S
----------
N
-
F
-
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
-----
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
N
E
----
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
-
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
--
P
P
---------------------------------------------------------------------
523
Blastp_CBE
62.83
39%
-117
- C2 -
-
3QCY
8.8
-
PDPK1_HUMAN
A:
[34-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
-
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
S
--------------
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
-----
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
N
E
----
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
-
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
--
P
P
---------------------------------------------------------------------
98
Blastp_CBE
62.82
47%
-37
- C2 -
-
4Q9Z
5.3
-
B:
[1-320]
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
L
K
I
E
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
F
---
K
K
---
T
-
N
----
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
--
M
-
D
D
D
V
E
C
T
M
V
E
K
R
V
L
-
S
---
L
A
W--
E
-
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
--
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
-
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
K
--
E
N
M
L
G
D
-
A
K
T
N
--
E
-
F
-
C
--
G
T
P
D
Y
I
A
P
E
I
L
L
G
-----
Q
---
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
-
Q
S
P
F
-----
H
--
G
---
Q
D
E
----
E
---
E
L
F
H
S
I
--
R
--
M
D
N
P
--
F
Y
P
-----
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
G
V
------------
R
-
G
D
-
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
--
P
-----
K
V
K
S
P
F
D
C
S
N
F
D
-
K
E
F
L
N
E
----------------------------------------
96
Blastp_CBE
62.78
47%
-45
- C2 -
-
4RA5
6.2
-
B:
[2-320]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
I
E
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
F
---
K
K
---
T
-
N
----
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
--
M
-
D
D
D
V
E
C
T
M
V
E
K
R
V
L
-
S
---
L
A
W--
E
-
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
--
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
-
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
K
--
E
N
M
L
G
D
-
A
K
T
N
--
E
-
F
-
C
--
G
T
P
D
Y
I
A
P
E
I
L
L
G
-----
Q
---
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
-
Q
S
P
F
-----
H
--
G
---
Q
D
E
----
E
---
E
L
F
H
S
I
--
R
--
M
D
N
P
--
F
Y
P
-----
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
G
V
------------
R
-
G
D
-
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
--
P
-----
K
V
K
S
P
F
D
C
S
N
F
D
-
K
E
F
L
N
E
----------------------------------------
527
Blastp_CBE
62.76
39%
-118
- C2 -
-
3IOP
9.3
-
PDPK1_HUMAN
A:
[34-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
-
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
S
----------
N
-
F
-
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
-----
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
N
E
----
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
-
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
--
P
P
---------------------------------------------------------------------
525
Blastp_CBE
62.74
39%
-119
- C2 -
-
3QCS
6.3
-
PDPK1_HUMAN
A:
[34-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
-
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
S
----------
N
-
F
-
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
-----
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
N
E
----
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
-
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
--
P
P
---------------------------------------------------------------------
53
Blastp_CBE
62.68
46%
-32
- C2 -
-
4DC2
3.8
-
KPCI_MOUSE
A:
[49-384]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
---
K
K
---
T
-
D
----
R
I
Y
A
M
R
V
V
K
K
E
L
V
N
-------
I
D
W
V
Q
T
E
K
H
V
F
E
Q
---
A
S
---
N
-
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
--
E
G
L
R
P
G
-
D
T
T
S
--
T
-
F
-
C
--
G
T
P
N
Y
I
A
P
E
I
L
R
G
-----
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
DIVGS----------NTE-
D
---
Y
L
F
Q
V
I
--
L
--
E
K
Q
I
--
R
I
P
-----
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
------
H
-
P
-
Q
T
G
F
A
D
-
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
--
P
-----
N
I
S
G
E
F
G
L
D
N
F
D
-
S
Q
F
T
N
E
P
V
Q
L
T
-
P
D
D
D
D
I
--
V
R
K
I
D
Q
-
S
E
---
F
E
--
G
F
E
Y
------
93
Blastp_CBE
62.67
46%
-40
- C2 -
-
5F9E
8.7
-
KPCT_HUMAN
A:
[15-312]
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
L
K
I
E
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
F
---
K
K
---
T
-
N
----
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
--
M
-
D
D
D
V
E
C
T
M
V
E
K
R
V
L
-
S
---
L
A
W--
E
-
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
--
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
-
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
K
--
E
N
M
L
G
D
-
A
K
T
N
--
E
-
F
-
C
--
G
T
P
D
Y
I
A
P
E
I
L
L
G
-----
Q
---
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
-
Q
S
P
F
-----
H
--
G
---
Q
D
E
----
E
---
E
L
F
H
S
I
--
R
--
M
D
N
P
--
F
Y
P
-----
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
G
V
------------
R
-
G
D
-
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
--
P
-----
K
V
K
S
P
F
D
C
S
N
F
D
-
K
E
F
L
N
E
----------------------------------------
530
Blastp_CBE
62.63
39%
-121
- C2 -
-
1UU3
8.2
-
PDPK1_HUMAN
A:
[31-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
-
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
S
------------
F
-
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
-----
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
N
E
----
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
-
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
--
P
P
---------------------------------------------------------------------
480
Blastp_CBE
62.54
39%
-115
- C2 -
-
3NUS
3.6
-
PDPK1_HUMAN
A:
[9-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
-
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
S
----------
N
-
F
-
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
-----
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
N
E
----
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
-
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
--
P
P
---------------------------------------------------------------------
479
Blastp_CBE
62.54
39%
-116
- C2 -
-
3NUU
3.6
-
PDPK1_HUMAN
A:
[9-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
-
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
S
----------
N
-
F
-
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
-----
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
N
E
----
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
-
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
--
P
P
---------------------------------------------------------------------
475
Blastp_CBE
62.54
39%
-115
- C2 -
-
2PE1
6.0
-
PDPK1_HUMAN
A:
[8-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
-
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
S
------------
F
-
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
-----
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
N
E
----
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
-
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
--
P
P
---------------------------------------------------------------------
476
Blastp_CBE
62.50
39%
-117
- C2 -
-
2PE0
5.3
-
PDPK1_HUMAN
A:
[8-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
-
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
S
------------
F
-
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
-----
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
N
E
----
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
-
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
--
P
P
---------------------------------------------------------------------
526
Blastp_CBE
62.44
39%
-116
- C2 -
-
3QCQ
6.1
-
PDPK1_HUMAN
A:
[34-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
-
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
S
----------
N
-
F
-
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
-----
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
N
E
----
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
-
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
--
P
P
---------------------------------------------------------------------
522
Blastp_CBE
62.35
39%
-114
- C2 -
-
3QD0
8.6
-
PDPK1_HUMAN
A:
[34-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
-
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
S
-----------------
G
T
A
Q
Y
V
S
P
E
L
L
T
E
-----
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
N
E
----
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
-
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
--
P
P
---------------------------------------------------------------------
488
Blastp_CBE
62.33
39%
-115
- C2 -
-
3NUN
5.4
-
PDPK1_HUMAN
A:
[15-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
-
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
S
----------
N
-
F
-
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
-----
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
N
E
----
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
-
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
--
P
P
---------------------------------------------------------------------
477
Blastp_CBE
62.20
39%
-115
- C2 -
-
1Z5M
6.8
-
PDPK1_HUMAN
A:
[8-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
-
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
S
------------
F
-
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
-----
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
N
E
----
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
-
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
--
P
P
---------------------------------------------------------------------
478
Blastp_CBE
62.16
39%
-116
- C2 -
-
3NUY
3.8
-
PDPK1_HUMAN
A:
[9-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
-
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
S
----------
N
-
F
-
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
-----
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
N
E
----
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
-
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
--
P
P
---------------------------------------------------------------------
520
Blastp_CBE
62.08
39%
-113
- C2 -
-
3QD4
8.7
-
PDPK1_HUMAN
A:
[34-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
-
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
S
-----------------
G
T
A
Q
Y
V
S
P
E
L
L
T
E
-----
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
N
E
----
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
-
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
--
P
P
---------------------------------------------------------------------
532
Blastp_CBE
62.02
39%
-107
- C2 -
-
1OKY
8.4
-
PDPK1_HUMAN
A:
[31-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
-
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
S
P
E
S
-------
N
-
F
-
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
-----
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
N
E
----
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
-
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
--
P
P
---------------------------------------------------------------------
467
Blastp_CBE
61.93
39%
-114
- C2 -
-
1UU9
3.2
-
PDPK1_HUMAN
A:
[10-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
-
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
S
----------
N
-
F
-
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
-----
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
N
E
----
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
-
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
--
P
P
---------------------------------------------------------------------
531
Blastp_CBE
61.79
39%
-116
- C2 -
-
1OKZ
8.7
-
PDPK1_HUMAN
A:
[31-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
-
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
S
----------
N
-
F
-
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
-----
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
N
E
----
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
-
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
--
P
P
---------------------------------------------------------------------
534
Blastp_CBE
61.60
39%
-108
- C2 -
-
3QC4
10.1
-
PDPK1_HUMAN
A:
[36-311]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
-
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
S
P
E
S
---------
F
-
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
-----
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
N
E
----
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
A
A
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
-
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
--
P
P
---------------------------------------------------------------------
573
HHSearch
61.34
45%
-54
- C2 -
-
1XJD
7.8
-
A:
[16-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
D
F
I
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
F
---
K
K
---
T
-
N
----
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
--
M
-
D
D
D
V
E
C
T
M
V
E
K
R
V
L
-
S
L--
A
W
---
E
-
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
--
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
-
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
K
--
E
N
M
L
G
D
-
A
K
T
N
--
T
-
F
-
C
--
G
T
P
D
Y
I
A
P
E
I
L
L
G
-----
Q
---
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
-
Q
S
P
F
-----
H
--
G
---
Q
D
E
----
E
---
E
L
F
H
S
I
--
R
--
M
D
N
P
--
F
Y
P
-----
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
G
V
------------
R
-
G
D
-
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
--------------------------------------------------
Q
N
M
---
F
R
--
N
F
S
F
------
92
Blastp_CBE
61.05
46%
-44
- C2 -
-
5F9E
7.8
-
B:
[16-340]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
I
E
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
F
---
K
K
---
T
-
N
----
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
--
M
-
D
D
D
V
E
C
T
M
V
E
K
R
V
L
-
S
---
L
A
W--
E
-
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
--
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
-
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
K
--
E
N
M
L
G
D
-
A
K
T
N
--
E
-
F
-
C
--
G
T
P
D
Y
I
A
P
E
I
L
L
G
-----
Q
---
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
-
Q
S
P
F
-----
H
--
G
---
Q
D
E
----
E
---
E
L
F
H
S
I
--
R
--
M
D
N
P
--
F
Y
P
-----
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
G
V
------------
R
-
G
D
-
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
--
P
-----
K
V
K
S
P
F
--
S
N
F
D
---
F
L
N
E
----------------------------------------
533
Blastp_CBE
60.75
39%
-115
- C2 -
-
3QC4
9.6
-
PDPK1_HUMAN
B:
[36-311]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
-----------
V
T
R
E
R
D
V
M
-
S
---
R
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
S
P
E
S
---------
F
-
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
-----
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
N
E
----
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
A
A
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
-
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
--
P
P
---------------------------------------------------------------------
578
HHSearch
60.62
45%
-40
- C2 -
-
3TXO
6.1
-
KPCL_HUMAN
A:
[23-349]
---------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
F
E
F
I
R
V
L
G
K
G
-
S
F
G
K
V
M
L
A
R
V
---
K
E
---
T
-
G
----
D
L
Y
A
V
K
V
L
K
K
D
V
I
L
--
Q
-
D
D
D
V
E
C
T
M
T
E
K
R
I
L
-
S
---
L
A
R--
N
-
H
P
F
L
T
Q
L
F
C
C
F
Q
T
P
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
--
S
R
R
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
-
K
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
H
E
G
H
C
K
L
A
D
F
G
M
C
K
--
E
G
I
--------------
C
--
G
T
P
D
Y
I
A
P
E
I
L
Q
E
-----
M
---
L
-----
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
-
H
A
P
F
-----
E
--
A
---
E
N
E
----
D
---
D
L
F
E
A
I
--
L
--
N
D
E
V
--
V
Y
P
-----
T
W
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
--
R
L
G
S
------
L
T
Q
-
G
G
E
-
H
A
-
I
L
R
H
P
F
F
K
E
I
D
---
W
A
Q
L
N
H
R
Q
I
E
P
P
F
R
--
P
-----
R
I
K
S
R
E
D
V
S
N
F
D
-
P
D
F
I
K
E
E
P
V
L
T
P
I
D
E
G
-
H
---
L
P
M
I
N
Q
D
E
---
F
R
--
N
F
E
Y
V
S
P
---
50
Blastp_CBE
60.52
52%
-66
- C2 -
-
3HDM
7.0
-
SGK1_HUMAN
A:
[38-320]
---------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
F
H
F
L
K
V
I
G
K
G
-
S
F
G
K
V
L
L
A
R
H
---
K
A
---
E
-
E
----
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
----------------
V
L
L
K
---
N
V
---
K
-
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
--
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
-
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
--
E
N
I
E
H
N
-
S
T
T
S
--
T
-
F
-
C
--
G
T
P
E
Y
L
A
P
E
V
L
H
K
-----
Q
---
P
-----
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
-
L
P
P
F
-----
Y
--
S
---
R
N
T
----
A
---
E
M
Y
D
N
I
--
L
--
N
K
P
L
--
Q
L
K
-----
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
--
R
L
G
A
------
K
---
D
D
F
-
M
E
-
I
K
S
H
V
F
F
S
L
I
N
---
W
D
D
L
I
N
K
K
I
T
P
P
F
N
--
P
-----
N
V
S
G
-------------------------------------------------------
585
HHSearch
60.49
35%
-57
- C2 -
-
6ED6
7.9
-
ROCK2_HUMAN
A:
[84-413]
-----------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
K
A
E
D
Y
D
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
H
---
K
A
---
S
-
Q
----
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
--
K
-
R
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
---
F
A
---
N
-
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
---
Y
D
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
-
G
L
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
H
G
H
L
K
L
A
D
F
G
T
C
M
--
K
M
D
E
T
G
M
V
H
C
D
--
T
-
A
-
V
--
G
T
P
D
Y
I
S
P
E
V
L
K
S
-----
Q
----F----
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
-
D
T
P
F
-----
Y
--
A
---
D
S
L
----
V
---
G
T
Y
S
K
I
--
M
--
D
H
K
N
SL
C
F
P
ED---
A
E
I
S
K
H
A
K
N
L
I
C
A
F
L
T
D
R
E
V
R
LG
R
N
-------------
G
V
-
E
E
-
I
R
Q
H
P
F
F
K
N
D
Q
---
W
H
W
D
N
I
R
E
T
A
A
P
V
V
--
P
-----
E
L
S
S
D
I
D
S
S
N
F
D
-
D
I
-------
E
T
F
P
I
P
-
K
A
F
----
V
G
N
Q
L
P
---
F
I
--
G
F
T
Y
------
79
Blastp_CBE
60.45
46%
-45
- C2 -
-
4RA4
6.9
-
KPCA_HUMAN
A:
[16-333]
-----------------------------------------------------------------------------------------------------------------------------------------------------
R
V
K
L
T
D
F
N
F
L
M
V
L
G
K
G
-
S
F
G
K
V
M
L
A
D
R
---
K
G
---
T
-
E
----
E
L
Y
A
I
K
I
L
K
K
D
V
V
I
--
Q
-
D
D
D
V
E
C
T
M
V
E
K
R
V
L
-
A
---
L
L
D--
K
-
P
P
F
L
T
Q
L
H
S
C
F
Q
T
V
D
R
L
Y
F
V
M
E
Y
V
N
G
G
D
L
M
Y
H
I
Q
Q
--
V
G
K
F
K
E
P
Q
A
V
F
Y
A
A
E
I
S
I
G
L
F
F
L
H
K
-
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
M
L
D
-
S
E
G
H
I
K
I
A
D
F
G
M
C
K
--
E
H
M
M
D
G
-
V
T
T
R
--
T
-
F
-
C
--
G
T
P
D
Y
I
A
P
E
I
I
A
Y
-----
Q
---
P
-----
Y
G
K
S
V
D
W
W
A
Y
G
V
L
L
Y
E
M
L
A
G
-
Q
P
P
F
-----
D
--
G
---
E
D
E
----
D
---
E
L
F
Q
S
I
--
M
--
E
H
N
V
--
S
Y
P
-----
K
S
L
S
K
E
A
V
S
I
C
K
G
L
M
T
K
H
P
A
K
--
R
L
G
C
------
G
-
P
-
E
G
E
-
R
D
-
V
R
E
H
A
F
F
R
R
I
D
---
W
E
K
L
E
N
R
E
I
Q
P
P
F
K
--
P
-----
K
------------------
G
Q
P
V
L
P
P
D
Q
---
L
V
I
A
N
I
D
Q
--------------------
52
Blastp_CBE
60.17
44%
-46
- C2 -
-
3TXO
6.1
-
KPCL_HUMAN
A:
[23-348]
---------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
F
E
F
I
R
V
L
G
K
G
-
S
F
G
K
V
M
L
A
R
V
---
K
E
---
T
-
G
----
D
L
Y
A
V
K
V
L
K
K
D
V
I
L
--
Q
-
D
D
D
V
E
C
T
M
T
E
K
R
I
L
-
S
---
L
A
---
R
N
H
P
F
L
T
Q
L
F
C
C
F
Q
T
P
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
--
S
R
R
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
-
K
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
H
E
G
H
C
K
L
A
D
F
G
M
C
K
--
E
G
I
--------------
C
--
G
T
P
D
Y
I
A
P
E
I
L
Q
E
-----
M
---
L
-----
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
-
H
A
P
F
-----
E
--
A
---
E
N
E
----
D
---
D
L
F
E
A
I
--
L
--
N
D
E
V
--
V
Y
P
-----
T
W
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
--
R
L
G
S
------
L
-
T
-
Q
G
G
-
E
H
A
I
L
R
H
P
F
F
K
E
I
D
---
W
A
Q
L
N
H
R
Q
I
E
P
P
F
R
--
P
-----
R
I
K
S
R
E
D
V
S
N
F
D
-
P
D
F
I
K
E
E
-
P
V
L
P
I
D
E
----
G
H
L
P
M
I
N
Q
D
E
---
F
R
--
N
F
E
Y
V
S
----
51
Blastp_CBE
60.15
52%
-67
- C2 -
-
2R5T
6.8
-
SGK1_HUMAN
A:
[38-320]
---------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
F
H
F
L
K
V
I
G
K
G
-
S
F
G
K
V
L
L
A
R
H
---
K
A
---
E
-
E
----
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
----------------
V
L
L
K
---
N
V
---
K
-
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
--
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
-
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
--
E
N
I
E
H
N
-
S
T
T
S
--
T
-
F
-
C
--
G
T
P
E
Y
L
A
P
E
V
L
H
K
-----
Q
---
P
-----
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
-
L
P
P
F
-----
Y
--
S
---
R
N
T
----
A
---
E
M
Y
D
N
I
--
L
--
N
K
P
L
--
Q
L
K
-----
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
--
R
L
G
A
------
K
---
D
D
F
-
M
E
-
I
K
S
H
V
F
F
S
L
I
N
---
W
D
D
L
I
N
K
K
I
T
P
P
F
N
--
P
-----
N
V
S
G
-------------------------------------------------------
49
Blastp_CBE
59.35
52%
-71
- C2 -
-
3HDN
7.0
-
SGK1_HUMAN
A:
[38-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
F
H
F
L
K
V
I
G
K
G
-
S
F
G
K
V
L
L
A
R
H
---
K
A
---
E
-
E
----
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
----------------
V
L
L
K
---
N
V
---
K
-
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
--
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
-
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
--
E
N
I
E
H
N
-
S
T
T
S
--
T
-
F
-
C
--
G
T
P
E
Y
L
A
P
E
V
L
H
K
-----
Q
---
P
-----
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
-
L
P
P
F
-----
Y
--
S
---
R
N
T
----
A
---
E
M
Y
D
N
I
--
L
--
N
K
P
L
--
Q
L
K
-----
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
--
R
L
G
A
------
K
---
D
D
F
-
M
E
-
I
K
S
H
V
F
F
S
L
I
N
---
W
D
D
L
I
N
K
K
I
T
P
P
F
N
--
P
----------------------------------------------------------------
77
Blastp_CBE
59.19
46%
-1
- C2 -
-
4L43
7.7
-
KS6B1_HUMAN
A:
[10-344]
-------------------------------------------------------------------------------------------------------------------------------------------------
R
G
P
E
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
RN
A
-
K
D
-
T
A
H
T
K
A
E
R
N
I
L
-
E
---
E
V
---
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
--
E
S
------------------
G
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
--
G
---
E
N
R
----
K
---
K
T
I
D
K
I
--
L
--
K
C
K
L
--
N
L
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
------
G
-
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
--
P
-----
L
L
Q
S
E
E
D
V
S
Q
F
D
-
S
K
F
T
R
Q
----
T
P
V
----------
S
A
N
Q
V
----
F
L
--
G
F
A
Y
V
A
----
543
Blastp_CBE
58.89
38%
-32
- C2 -
-
4UAK
4.5
-
MRCKB_HUMAN
A:
[77-398]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
E
I
I
K
V
I
G
R
G
-
A
F
G
E
V
A
V
V
K
M
---
K
N
---
T
-
E
----
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
--
K
-
R
A
E
T
A
C
F
R
E
E
R
D
V
L
-
V
---
N
G
---
D
-
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F-
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
-
L
-
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
-
V
N
G
H
I
R
L
A
D
F
G
S
C
L
--
K
M
N
D
D
G
-
T
V
Q
S
--
S
-
V
-
A
V-
G
T
P
D
Y
I
S
P
E
I
L
Q
A
MEDGM
G
---
K
-----
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
-
E
T
P
F
-----
Y
--
A
---
E
S
L
----
V
---
E
T
Y
G
K
I
--
M
--
N
H
E
E
--
R
F
Q
FPSHV
T
D
V
S
E
E
A
K
D
L
I
Q
R
L
I
C
S
R
E
R
R
--
L
G
Q
N
------
G
-
I
-
E
D
F
-
K
----
K
H
A
F
F
E
G
L
N
---
W
E
N
I
--
R
N
L
E
A
P
Y
I
--
P
-----
D
V
S
S
P
S
D
T
S
N
F
D
---------------
S
H
T
G
F
S
G
L
H
L
----------------------
542
Blastp_CBE
58.85
38%
-26
- C2 -
-
4UAL
6.5
-
MRCKB_HUMAN
A:
[77-398]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
E
I
I
K
V
I
G
R
G
-
A
F
G
E
V
A
V
V
K
M
---
K
N
---
T
-
E
----
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
--
K
-
R
A
E
T
A
C
F
R
E
E
R
D
V
L
-
V
---
N
G
---
D
-
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F-
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
-
L
-
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
-
V
N
G
H
I
R
L
A
D
F
G
S
C
L
--
K
M
N
D
D
G
-
T
V
------
V
-
A
V-
G
T
P
D
Y
I
S
P
E
I
L
Q
A
MED--
G
---
K
-----
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
-
E
T
P
F
-----
Y
--
A
---
E
S
L
----
V
---
E
T
Y
G
K
I
--
M
--
N
H
E
E
--
R
F
Q
FPSHV
T
D
V
S
E
E
A
K
D
L
I
Q
R
L
I
C
S
R
E
R
R
--
L
G
Q
N
------
G
-
I
-
E
D
F
-
K
----
K
H
A
F
F
E
G
L
N
---
W
E
N
I
--
R
N
L
E
A
P
Y
I
--
P
-----
D
V
S
S
P
S
D
T
S
N
F
D
V---------
I
L
P
P
--
H
T
G
F
S
G
L
H
L
----------------------
80
Blastp_CBE
58.78
47%
-6
- C2 -
-
4L46
8.1
-
KS6B1_HUMAN
A:
[9-346]
------------------------------------------------------------------------------------------------------------------------------------------------
N
R
G
P
E
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
RN
A
-
K
D
-
T
A
H
T
K
A
E
R
N
I
L
-
E
---
E
V
---
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
--
E
S
I
H
D
-----
H
--
T
-
F
-
C
--
G
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
--
G
---
E
N
R
----
K
---
K
T
I
D
K
I
--
L
--
K
C
K
L
--
N
L
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
------
G
-
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
--
P
-----
L
---
E
E
D
V
S
Q
F
D
-
S
K
F
T
R
Q
T
P
V
D
S
P
D
D
--------------------------------
540
Blastp_CBE
58.57
38%
-30
- C2 -
-
5OTF
6.4
-
MRCKB_HUMAN
A:
[77-398]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
E
I
I
K
V
I
G
R
G
-
A
F
G
E
V
A
V
V
K
M
---
K
N
---
T
-
E
----
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
--
K
-
R
A
E
T
A
C
F
R
E
E
R
D
V
L
-
V
---
N
G
---
D
-
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F-
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
-
L
-
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
-
V
N
G
H
I
R
L
A
D
F
G
S
C
L
--
K
M
N
D
D
G
-
T
V
Q
S
--
S
-
V
-
A
V-
G
T
P
D
Y
I
S
P
E
I
L
Q
A
MEDGM
G
---
K
-----
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
-
E
T
P
F
-----
Y
--
A
---
E
S
L
----
V
---
E
T
Y
G
K
I
--
M
--
N
H
E
E
--
R
F
Q
FPSHV
T
D
V
S
E
E
A
K
D
L
I
Q
R
L
I
C
S
R
E
R
R
--
L
G
Q
N
------
G
-
I
-
E
D
F
-
K
----
K
H
A
F
F
E
G
L
N
---
W
E
N
I
--
R
N
L
E
A
P
Y
I
--
P
-----
D
V
S
S
P
S
D
T
S
N
F
D
V--------
E
I
L
P
P
G
S
H
T
G
F
S
G
L
H
L
----------------------
538
Blastp_CBE
58.25
39%
-77
- C2 -
-
3NAY
7.6
-
PDPK1_HUMAN
A:
[30-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
-
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
S
--------A-
N
-
F
-
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
-----
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
N
E
----
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
-
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
--
P
P
---------------------------------------------------------------------
76
Blastp_CBE
58.12
46%
7
- C2 -
-
4L44
7.8
-
KS6B1_HUMAN
A:
[10-344]
-------------------------------------------------------------------------------------------------------------------------------------------------
R
G
P
E
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
RN
A
-
K
D
-
T
A
H
T
K
A
E
R
N
I
L
-
E
---
E
V
---
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
--
E
S
I
H
------
H
--
T
-
F
-
C
--
G
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
--
G
---
E
N
R
----
K
---
K
T
I
D
K
I
--
L
--
K
C
K
L
--
N
L
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
------
G
-
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
--
P
-----
L
L
Q
S
E
E
D
V
S
Q
-
D
-
S
K
F
T
R
Q
----
T
----------
S
E
S
A
N
Q
V
----
F
L
--
G
F
A
Y
V
A
----
548
Blastp_CBE
57.85
38%
-26
- C2 -
-
3TKU
4.9
-
MRCKB_HUMAN
A:
[91-419]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
E
I
I
K
V
I
G
R
G
-
A
F
G
E
V
A
V
V
K
M
---
K
N
---
T
-
E
----
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
--
K
-
R
A
E
T
A
C
F
R
E
E
R
D
V
L
-
V
---
N
G
---
D
-
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F-
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
-
L
-
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
-
V
N
G
H
I
R
L
A
D
F
G
S
C
L
--
K
M
N
D
D
G
-
T
V
Q
S
--
S
-
V
-
A
V-
G
T
P
D
Y
I
S
P
E
I
L
Q
A
MEDGM
G
---
K
-----
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
-
E
T
P
F
-----
Y
--
A
---
E
S
L
----
V
---
E
T
Y
G
K
I
--
M
--
N
H
E
E
--
R
F
Q
FPSHV
T
D
V
S
E
E
A
K
D
L
I
Q
R
L
I
C
S
R
E
R
R
--
L
G
Q
N
------
G
-
I
-
E
D
F
-
K
----
K
H
A
F
F
E
G
L
N
---
W
E
N
I
--
R
N
L
E
A
P
Y
I
--
P
-----
D
V
S
S
P
S
D
T
S
N
F
D
V------------
P
G
S
H
T
G
F
S
G
L
H
L
----------------------
456
Blastp_CBE
57.83
39%
-24
- C2 -
-
3NYO
4.7
-
GRK6_HUMAN
A:
[178-496]
---------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
-
G
F
G
E
V
C
A
C
Q
V
---
R
A
---
T
-
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
K
--
K
-
R
K
G
E
A
M
A
L
N
E
K
Q
I
L
-
E
---
K
V
---
N
-
S
R
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
MG
Q
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
-
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
D
H
G
H
I
R
I
S
D
L
G
L
A
V
--
H
-
V
P
E
G
-
Q
T
I
K
--
G
-
R
-
V
--
G
T
V
G
Y
M
A
P
E
V
V
K
N
-----
E
---
R
-----
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
-
Q
S
P
F
-----
Q
--------
K
----
K
---
I
K
R
E
E
V
ER
L
--
V
K
E
V
PE
E
Y
S
-----
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
--
R
L
G
C
------
R
-
G
-
G
S
A
-
R
E
-
V
K
E
H
P
L
F
K
K
L
N
---
F
K
R
L
G
A
G
M
L
E
P
P
F
K
PD
P
-----
Q
A
I
Y
C
K
D
V
L
D
I
E
-
Q
F
S
T
V
K
G
V
E
L
E
P
T
D
Q
-------------------------------
547
Blastp_CBE
57.82
38%
-25
- C2 -
-
3TKU
5.1
-
MRCKB_HUMAN
B:
[91-419]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
E
I
I
K
V
I
G
R
G
-
A
F
G
E
V
A
V
V
K
M
---
K
N
---
T
-
E
----
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
--
K
-
R
A
E
T
A
C
F
R
E
E
R
D
V
L
-
V
---
N
G
---
D
-
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F-
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
-
L
-
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
-
V
N
G
H
I
R
L
A
D
F
G
S
C
L
--
K
M
N
D
D
G
-
T
V
Q
S
--
S
-
V
-
A
V-
G
T
P
D
Y
I
S
P
E
I
L
Q
A
MEDGM
G
---
K
-----
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
-
E
T
P
F
-----
Y
--
A
---
E
S
L
----
V
---
E
T
Y
G
K
I
--
M
--
N
H
E
E
--
R
F
Q
FPSHV
T
D
V
S
E
E
A
K
D
L
I
Q
R
L
I
C
S
R
E
R
R
--
L
G
Q
N
------
G
-
I
-
E
D
F
-
K
----
K
H
A
F
F
E
G
L
N
---
W
E
N
I
--
R
N
L
E
A
P
Y
I
--
P
-----
D
V
S
S
P
S
D
T
S
N
F
D
V------------
P
G
S
H
T
G
F
S
G
L
H
L
----------------------
582
HHSearch
57.78
46%
8
- C2 -
-
4L44
7.8
-
KS6B1_HUMAN
A:
[14-346]
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
---
V
T
GAN
T
-
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
--
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
-
E
---
E
V
---
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
--
E
S
I
H
------
H
--
T
-
F
-
C
--
G
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
--
G
---
E
N
R
----
K
---
K
T
I
D
K
I
--
L
--
K
C
K
L
--
N
L
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
------
G
-
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
--
P
-----
L
L
Q
S
E
E
D
V
S
Q
-
D
-
S
K
F
T
R
Q
T
---------------
S
E
S
A
N
Q
V
---
F
L
--
G
F
A
Y
V
A
P
S
--
535
Blastp_CBE
57.67
39%
-73
- C2 -
-
3SC1
4.7
-
PDPK1_HUMAN
A:
[33-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
-
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
S
--------A-
N
-
F
-
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
-----
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
N
E
----
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
-
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
--
P
P
---------------------------------------------------------------------
537
Blastp_CBE
57.33
39%
-79
- C2 -
-
3NAY
7.8
-
PDPK1_HUMAN
B:
[30-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
-
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
S
--------A-
N
-
F
-
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
-----
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
N
E
----
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
-
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
--
P
P
---------------------------------------------------------------------
459
Blastp_CBE
57.21
39%
-35
- C2 -
-
2ACX
4.8
-
GRK6_HUMAN
B:
[178-534]
---------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
-
G
F
G
E
V
C
A
C
Q
V
---
R
A
---
T
-
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
K
--
K
-
R
K
G
E
A
M
A
L
N
E
K
Q
I
L
-
E
---
K
V
---
N
-
S
R
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M--
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
-
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
D
H
G
H
I
R
I
S
D
L
G
L
A
V
--
H
-
V
P
E
G
-
Q
T
I
K
--
G
-
R
-
V
--
G
T
V
G
Y
M
A
P
E
V
V
K
N
-----
E
---
R
-----
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
-
Q
S
P
F
-----
Q
--
Q
----------
K
---
I
K
R
E
E
V
ER
L
--
V
K
E
V
PE
E
Y
S
-----
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
--
R
L
G
C
------
R
-
G
-
G
S
A
-
R
E
-
V
K
E
H
P
L
F
K
K
L
N
---
F
K
R
L
G
A
G
M
L
E
P
P
F
K
PD
P
-----
Q
A
I
Y
C
K
D
V
L
D
I
E
-
Q
F
S
T
V
K
G
V
E
L
E
P
T
D
Q
-------------------------------
518
Blastp_CBE
57.11
39%
-69
- C2 -
-
2XCH
7.3
-
PDPK1_HUMAN
A:
[31-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
-
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
S
--------A-
N
-
F
-
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
-----
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
N
E
----
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
-
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
--
P
P
---------------------------------------------------------------------
528
Blastp_CBE
57.04
39%
-73
- C2 -
-
1UU8
3.1
-
PDPK1_HUMAN
A:
[31-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
-
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
S
--------A-
N
-
F
-
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
-----
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
N
E
----
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
-
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
--
P
P
---------------------------------------------------------------------
541
Blastp_CBE
57.02
38%
-19
- C2 -
-
5OTE
6.1
-
MRCKB_HUMAN
A:
[77-398]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
E
I
I
K
V
I
G
R
G
-
A
F
G
E
V
A
V
V
K
M
---
K
N
---
T
-
E
----
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
--
K
-
R
A
E
T
A
C
F
R
E
E
R
D
V
L
-
V
---
N
G
---
D
-
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F-
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
-
L
-
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
-
V
N
G
H
I
R
L
A
D
F
G
S
C
L
--
K
M
N
D
D
G
-
T
V
Q
S
--
S
-
V
-
A
V-
G
T
P
D
Y
I
S
P
E
I
L
Q
A
MED--
G
---
K
-----
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
-
E
T
P
F
-----
Y
--
A
---
E
S
L
----
V
---
E
T
Y
G
K
I
--
M
--
N
H
E
E
--
R
F
Q
FPSHV
T
D
V
S
E
E
A
K
D
L
I
Q
R
L
I
C
S
R
E
R
R
--
L
G
Q
N
------
G
-
I
-
E
D
F
-
K
----
K
H
A
F
F
E
G
L
N
---
W
E
N
I
--
R
N
L
E
A
P
Y
I
--
P
-----
D
V
S
S
P
S
D
T
S
N
F
D
----------
I
L
P
P
G
S
H
T
G
F
S
G
L
H
L
----------------------
499
Blastp_CBE
56.91
37%
-59
- C2 -
-
3PWY
3.2
-
PDPK1_HUMAN
A:
[23-308]
------------------------------------------------------------------------------------------------------------------------------------------------
P
P
Q
P
R
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
-
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
C
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
VL
S
P
-----------
S
-
F
-
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
-----
K
---
S
-----
A
S
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
N
E
----
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
-
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
--
P
P
---------------------------------------------------------------------
545
Blastp_CBE
56.87
38%
-21
- C2 -
-
3QFV
3.3
-
MRCKB_HUMAN
A:
[75-403]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
E
I
I
K
V
I
G
R
G
-
A
F
G
E
V
A
V
V
K
M
---
K
N
---
T
-
E
----
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
--
K
-
R
A
E
T
A
C
F
R
E
E
R
D
V
L
-
V
---
N
G
---
D
-
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F-
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
-
L
-
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
-
V
N
G
H
I
R
L
A
D
F
G
S
C
L
--
K
M
N
D
D
G
-
T
V
Q
S
--
S
-
V
-
A
V-
G
T
P
D
Y
I
S
P
E
I
L
Q
A
MEDGM
G
---
K
-----
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
-
E
T
P
F
-----
Y
--
A
---
E
S
L
----
V
---
E
T
Y
G
K
I
--
M
--
N
H
E
E
--
R
F
Q
FPSHV
T
D
V
S
E
E
A
K
D
L
I
Q
R
L
I
C
S
R
E
R
R
--
L
G
Q
N
------
G
-
I
-
E
D
F
-
K
----
K
H
A
F
F
E
G
L
N
---
W
E
N
I
--
R
N
L
E
A
P
Y
I
--
P
-----
D
V
S
S
P
S
D
T
S
N
F
D
V------------
P
G
S
H
T
G
F
S
G
L
H
L
----------------------
544
Blastp_CBE
56.82
38%
-27
- C2 -
-
3QFV
4.1
-
MRCKB_HUMAN
B:
[75-396]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
E
I
I
K
V
I
G
R
G
-
A
F
G
E
V
A
V
V
K
M
---
K
N
---
T
-
E
----
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
--
K
-
R
A
E
T
A
C
F
R
E
E
R
D
V
L
-
V
---
N
G
---
D
-
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F-
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
-
L
-
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
-
V
N
G
H
I
R
L
A
D
F
G
S
C
L
--
K
M
N
D
D
G
-
T
V
Q
S
--
S
-
V
-
A
V-
G
T
P
D
Y
I
S
P
E
I
L
Q
A
MEDGM
G
---
K
-----
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
-
E
T
P
F
-----
Y
--
A
---
E
S
L
----
V
---
E
T
Y
G
K
I
--
M
--
N
H
E
E
--
R
F
Q
FPSHV
T
D
V
S
E
E
A
K
D
L
I
Q
R
L
I
C
S
R
E
R
R
--
L
G
Q
N
------
G
-
I
-
E
D
F
-
K
----
K
H
A
F
F
E
G
L
N
---
W
E
N
I
--
R
N
L
E
A
P
Y
I
--
P
-----
D
V
S
S
P
S
D
T
S
N
F
D
------------------
G
F
S
G
L
H
L
----------------------
72
Blastp_CBE
56.74
46%
-9
- C2 -
-
4L42
7.6
-
KS6B1_HUMAN
A:
[13-344]
----------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
RN
A
-
K
D
-
T
A
H
T
K
A
E
R
N
I
L
-
E
---
E
V
---
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
--
E
S
I
H
D
G
-
T
V
T
H
--
T
-
F
-
C
--
G
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
--
G
---
E
N
R
----
K
---
K
T
I
D
K
I
--
L
--
K
C
K
L
--
N
L
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
------
G
-
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
-----------------------------------------------
E
M
----
F
R
--
D
F
E
Y
I
A
----
78
Blastp_CBE
56.71
47%
2
- C2 -
-
4L45
8.2
-
KS6B1_HUMAN
A:
[10-335]
-------------------------------------------------------------------------------------------------------------------------------------------------
R
G
P
E
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
RN
A
-
K
D
-
T
A
H
T
K
A
E
R
N
I
L
-
E
---
E
V
---
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
--
E
S
------------------
G
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
--
G
---
E
N
R
----
K
---
K
T
I
D
K
I
--
L
--
K
C
K
L
--
N
L
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
------
G
-
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
--
P
-----
L
L
Q
S
E
E
D
V
S
Q
F
D
-
S
K
F
T
R
Q
T
P
V
D
S
P
D
D
--------------------------------
461
Blastp_CBE
56.65
38%
-25
- C2 -
-
5UVC
7.0
-
ARBK1_HUMAN
A:
[195-545]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
-
G
F
G
E
V
Y
G
C
R
K
---
A
D
---
T
-
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
K
--
M
-
K
Q
G
E
T
L
A
L
N
E
R
I
M
L
-
S
LVS
T
G
---
D
-
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
--
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
-
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
-
E
H
G
H
V
R
I
S
D
L
G
L
A
------
C
D
F
-
S
K
K
K
--
P
-
H
-
A
SV
G
T
H
G
Y
M
A
P
E
V
L
Q
K
-----
G
V--
A
-----
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
-
H
S
P
F
-----
R
--
Q
HKT
K
D
K
----
H
---
E
I
D
R
M
T
--
L
--
T
M
A
V
--
E
L
P
-----
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
--
R
L
G
C
------
L
-
G
-
R
G
A
-
Q
E
-
V
K
E
S
P
F
F
R
S
L
D
---
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
--
P
PRGEV
N
A
A
D
A
F
D
I
G
S
F
D
-
E
E
D
T
------------------------------------------
455
Blastp_CBE
56.64
39%
-20
- C2 -
-
3NYO
4.7
-
GRK6_HUMAN
B:
[178-496]
---------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
-
G
F
G
E
V
C
A
C
Q
V
---
R
A
---
T
-
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
K
--
K
-
R
K
G
E
A
M
A
L
N
E
K
Q
I
L
-
E
---
K
V
---
N
-
S
R
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
MG
Q
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
-
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
D
H
G
H
I
R
I
S
D
L
G
L
A
V
--
H
-
V
P
E
G
-
Q
T
I
K
--
G
-
R
-
V
--
G
T
V
G
Y
M
A
P
E
V
V
K
N
-----
E
---
R
-----
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
-
Q
S
P
F
-----
Q
--------
K
----
K
---
I
K
R
E
E
V
ER
L
--
V
K
E
V
PE
E
Y
S
-----
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
--
R
L
G
C
------
R
-
G
-
G
S
A
-
R
E
-
V
K
E
H
P
L
F
K
K
L
N
---
F
K
R
L
G
A
G
M
L
E
P
P
F
K
PD
P
-----
Q
A
I
Y
C
K
D
V
L
D
I
E
-
Q
F
S
T
V
K
G
V
E
L
E
P
T
D
Q
-------------------------------
453
Blastp_CBE
56.15
41%
-21
- C2 -
-
4TND
4.2
-
GRK5_HUMAN
A:
[178-467]
---------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
-
G
F
G
E
V
C
A
C
Q
V
---
R
A
---
T
-
G
----
K
M
Y
A
C
K
R
L
E
K
K
R
I
K
--
K
-
R
K
G
E
S
M
A
L
N
E
K
Q
I
L
-
E
---
K
V
---
N
-
S
Q
F
V
V
N
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
F
H
I
Y
N
MG
N
P
G
F
E
E
E
R
A
L
F
Y
A
A
E
I
L
C
G
L
E
D
L
H
H
-
E
-
N
T
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
D
Y
G
H
I
R
I
S
D
L
G
L
A
V
--
K
-
I
P
E
G
-
D
L
I
R
--
G
-
R
-
V
--
G
T
V
G
Y
M
A
P
E
V
L
N
N
-----
Q
---
R
-----
Y
G
L
S
P
D
Y
W
G
L
G
C
L
I
Y
E
M
I
E
G
-
Q
S
P
F
-----
R
--
G
---
R
K
E
KVKR
E
---
E
V
D
R
R
V
--
L
--
E
T
E
E
--
V
Y
S
-----
H
K
F
S
E
E
A
K
S
I
C
K
M
L
L
T
K
D
A
K
Q
--
R
L
G
C
------
Q
-
E
-
E
E
A
-
A
E
-
V
K
R
H
P
F
F
R
N
M
N
---
F
K
R
L
E
A
G
M
L
D
P
P
F
V
--
P
----------------------------------------------------------------
464
Blastp_CBE
56.10
39%
-67
- C2 -
-
2R7B
6.7
-
PDPK1_HUMAN
A:
[34-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
-
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
VL---------------
F
-
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
-----
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
N
E
----
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
-
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
--
P
P
---------------------------------------------------------------------
466
Blastp_CBE
56.08
39%
-53
- C2 -
-
2BIY
5.6
-
PDPK1_HUMAN
A:
[31-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
-
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
VL
S
P
E
S
K
Q
-
A
R
A
N
--
A
-
F
-
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
-----
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
N
E
----
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
-
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
--
P
P
---------------------------------------------------------------------
454
Blastp_CBE
55.90
41%
-18
- C2 -
-
4TNB
4.8
-
GRK5_HUMAN
A:
[178-467]
---------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
-
G
F
G
E
V
C
A
C
Q
V
---
R
A
---
T
-
G
----
K
M
Y
A
C
K
R
L
E
K
K
R
I
K
--
K
-
R
K
G
E
S
M
A
L
N
E
K
Q
I
L
-
E
---
K
V
---
N
-
S
Q
F
V
V
N
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
F
H
I
Y
N
MG
N
P
G
F
E
E
E
R
A
L
F
Y
A
A
E
I
L
C
G
L
E
D
L
H
H
-
E
-
N
T
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
D
Y
G
H
I
R
I
S
D
L
G
L
A
V
--
K
-
I
P
E
G
-
D
L
I
R
--
G
-
R
-
V
--
G
T
V
G
Y
M
A
P
E
V
L
N
N
-----
Q
---
R
-----
Y
G
L
S
P
D
Y
W
G
L
G
C
L
I
Y
E
M
I
E
G
-
Q
S
P
F
-----
R
--
G
---
R
K
E
KVKR
E
---
E
V
D
R
R
V
--
L
--
E
T
E
E
--
V
Y
S
-----
H
K
F
S
E
E
A
K
S
I
C
K
M
L
L
T
K
D
A
K
Q
--
R
L
G
C
------
Q
-
E
-
E
E
A
-
A
E
-
V
K
R
H
P
F
F
R
N
M
N
---
F
K
R
L
E
A
G
M
L
D
P
P
F
V
--
P
----------------------------------------------------------------
460
Blastp_CBE
55.80
39%
-21
- C2 -
-
2ACX
5.2
-
GRK6_HUMAN
A:
[178-532]
---------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
-
G
F
G
E
V
C
A
C
Q
V
---
R
A
---
T
-
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
K
--
K
-
R
K
G
E
A
M
A
L
N
E
K
Q
I
L
-
E
---
K
V
---
N
-
S
R
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
MG
Q
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
-
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
D
H
G
H
I
R
I
S
D
L
G
L
A
V
--
H
-
V
P
E
G
-
Q
T
I
K
--
G
-
R
-
V
--
G
T
V
G
Y
M
A
P
E
V
V
K
N
-----
E
---
R
-----
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
-
Q
S
P
F
-----
Q
--
Q
---
R
K
K
----
K
---
I
K
R
E
E
V
ER
L
--
V
K
E
V
PE
E
Y
S
-----
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
--
R
L
G
C
------
R
-
G
-
G
S
A
-
R
E
-
V
K
E
H
P
L
F
K
K
L
N
---
F
K
R
L
G
A
G
M
L
E
P
P
F
K
PD
P
-----
Q
A
I
Y
C
K
D
V
L
D
I
E
-
Q
F
S
T
V
K
G
V
E
L
E
P
T
D
Q
-------------------------------
557
Fugue
55.75
39%
-0
- C2 -
-
1CDK
8.0
-
KAPCA_PIG
A:
[8-350]
--------------------------------------------------------------------------------------------------------
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
--------
H
--------
L
D
Q
F
E
R
I
K
T
L
G
T
-G
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
G-----
N
H
F
A
M
K
I
L
D
K
Q
K
V
V
--
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
AV------
N
-
F
P
F
L
V
K
L
E
Y
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I--
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
--L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q-
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
V
-
K
---
G
--
R
TW
T
-
L
-
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
------KGY-------
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y-
P
P
F
-----
F
AD-----
Q
P
----
I
---
Q
I
Y
E
K
I
--
V
--
S
G
K
V
--
R
F
P
S-----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
-
K
-
D
G
V
-
N
D
-
I
K
N
H
K
W
F
A
---TTD
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
--
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
-
D
Y
E
E
E
E
I
R
V
S
I
--------
N
E
K
C
G
K
E
F
S
E
---
F
-------------
481
Blastp_CBE
55.66
38%
-15
- C2 -
-
5HE3
4.7
-
ARBK1_BOVIN
A:
[157-585]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
-
G
F
G
E
V
Y
G
C
R
K
---
A
D
---
T
-
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
K
--
M
-
K
Q
G
E
T
L
A
L
N
E
R
I
M
L
-
S
LVS
T
G
---
D
-
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
--
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
-
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
-
E
H
G
H
V
R
I
S
D
L
G
L
A
------
C
D
F
-
S
K
K
K
--
P
-
H
-
A
SV
G
T
H
G
Y
M
A
P
E
V
L
Q
K
-----
G
V--
A
-----
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
-
H
S
P
F
-----
R
--
Q
HKT
K
D
K
----
H
---
E
I
D
R
M
T
--
L
--
T
M
A
V
--
E
L
P
-----
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
--
R
L
G
C
------
L
-
G
-
R
G
A
-
Q
E
-
V
K
E
S
P
F
F
R
S
L
D
---
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
--
P
PRGEV
N
A
A
D
A
F
D
I
G
S
F
D
-
E
E
D
T
------------------------------------------
580
HHSearch
55.56
45%
-10
- C2 -
-
4OTH
7.4
-
A:
[7-339]
----------------------------------------------------------------------------------------------------------------------------------------------------
S
P
L
T
L
E
D
F
K
F
L
A
V
L
G
R
G
-
H
F
G
K
V
L
L
S
E
F
---
R
P
---
S
-
G
----
E
L
F
A
I
K
A
L
K
K
G
D
I
V
--
A
-
R
D
E
V
E
S
L
M
C
E
K
R
I
L
-
A
---
A
V
TSA
G
-
H
P
F
L
V
N
L
F
G
C
F
Q
T
P
E
H
V
C
F
V
M
E
Y
S
A
G
G
D
L
M
L
H
I
H
S
---
D
V
F
S
E
P
R
A
I
F
Y
S
A
C
V
V
L
G
L
Q
F
L
H
E
-
H
-
K
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
-
T
E
G
Y
V
K
I
A
D
F
G
L
C
K
---------------------------------------------------
T
R
A
V
D
W
W
G
L
G
V
L
L
Y
E
M
L
V
G
-
E
S
P
F
-----
P
--
G
---
D
D
E
----
E
---
E
V
F
D
S
I
--
V
--
N
D
E
V
--
R
Y
P
-----
R
F
L
S
A
E
A
I
G
I
M
R
R
L
L
R
R
N
P
E
R
--
R
L
G
S
------
S
-
E
-
R
D
A
-
E
D
-
V
K
K
Q
P
F
F
R
T
L
G
---
W
E
A
L
L
A
R
R
L
P
P
P
F
V
--
P
-----
T
L
S
G
R
T
D
V
S
N
F
D
-
E
E
F
T
G
E
A
P
T
L
S
P
P
R
D
A
R
P
L
---
T
A
A
E
Q
A
A
---
F
L
--
D
F
D
F
V
A
G
---
465
Blastp_CBE
55.55
39%
-63
- C2 -
-
3NAX
8.5
-
PDPK1_HUMAN
A:
[30-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
-
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
VL
S
P
E
S
K
Q
-
A
R
-------------
A
Q
Y
V
S
P
E
L
L
T
E
-----
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
N
E
----
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
-
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
--
P
P
---------------------------------------------------------------------
450
Blastp_CBE
55.45
35%
-93
- C2 -
-
5LOH
8.1
-
GWL_HUMAN
B:
[33-316]
---------------------------------------------------------------------------------------------------------------------------------------------------
P
---
S
I
E
E
F
S
I
V
K
P
I
S
R
G
-
A
F
G
K
V
Y
L
G
Q
K
---
G
------
G
----
K
L
Y
A
V
K
V
V
K
K
A
D
M
I
--
N
-
K
--------------
A
---
L
S
---
K
-
S
P
F
I
V
H
L
Y
Y
S
L
Q
S
A
N
N
V
Y
L
V
M
E
Y
L
I
G
G
D
V
K
S
L
L
H
I
--
Y
G
Y
F
D
E
E
M
A
V
K
Y
I
S
E
V
A
L
A
L
D
Y
L
H
R
-
H
-
G
I
I
H
R
D
L
K
P
D
N
M
L
I
S
-
N
E
G
H
I
K
L
T
D
F
G
L
------------------------
G
T
P
D
Y
L
A
P
E
L
L
L
G
-----
R
---
A
-----
H
G
P
A
V
D
W
W
A
L
G
V
C
L
F
E
F
L
T
G
-
I
P
P
F
-----
N
--
D
---
E
T
P
----
Q
---
Q
V
F
Q
N
I
--
L
--
K
R
D
I
--
P
W
P
EGE--
E
K
L
S
D
N
A
Q
S
A
V
E
I
L
L
T
I
D
D
T
K
--
R
A
G
-------------
M
-
K
E
-
L
K
R
H
P
L
F
S
D
V
D
---
W
E
N
L
Q
H
Q
T
M
--
P
F
I
--
P
-----
Q
P
---------------------------------------------------------
94
Blastp_CBE
55.34
47%
-9
- C2 -
-
4L3L
7.9
-
KS6B1_HUMAN
A:
[14-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
RN
A
-
K
D
-
T
A
H
T
K
A
E
R
N
I
L
-
E
---
E
V
---
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
--
E
S
I
H
D
G
-
T
V
T
H
--
T
-
F
-
C
--
G
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
--
G
---
E
N
R
----
K
---
K
T
I
D
K
I
--
L
--
K
C
K
L
--
N
L
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
------
G
-
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
--
P
-----
L
L
Q
S
-------------------------------------------------------
90
Blastp_CBE
55.32
47%
-14
- C2 -
-
3WE4
5.0
-
KS6B1_HUMAN
A:
[15-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
RN
A
-
K
D
-
T
A
H
T
K
A
E
R
N
I
L
-
E
---
E
V
---
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
--
E
S
I
H
D
----
V
T
--
H
-
F
-
C
--
G
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
--
G
---
E
N
R
----
K
---
K
T
I
D
K
I
--
L
--
K
C
K
L
--
N
L
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
------
G
-
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
--
P
-----
L
L
Q
--------------------------------------------------------
95
Blastp_CBE
55.31
47%
-7
- C2 -
-
4L3J
7.9
-
KS6B1_HUMAN
A:
[14-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
RN
A
-
K
D
-
T
A
H
T
K
A
E
R
N
I
L
-
E
---
E
V
---
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
--
E
S
I
H
D
G
-
T
V
T
H
--
T
-
F
-
C
--
G
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
--
G
---
E
N
R
----
K
---
K
T
I
D
K
I
--
L
--
K
C
K
L
--
N
L
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
------
G
-
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
--
P
-----
L
L
Q
S
-------------------------------------------------------
58
Blastp_CBE
55.30
46%
-26
- C2 -
-
5LI9
6.6
-
KPCI_HUMAN
A:
[3-338]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
---
K
K
---
T
-
D
----
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
--
D
-
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
---
A
S
---
N
-
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
--
E
G
L
R
P
G
-
D
T
-
T
--
S
-
F
-
C
--
G
T
P
N
Y
I
A
P
E
I
L
R
G
-----
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
D--------------E---
D
---
Y
L
F
Q
V
I
--
L
--
E
K
Q
I
--
R
I
P
-----
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
------
H
-
P
-
Q
T
G
F
A
D
-
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
--
P
-----
N
I
S
G
E
F
G
L
D
N
F
D
-
S
Q
F
T
N
E
P
V
Q
L
--
P
D
D
D
D
I
--
V
R
K
I
D
Q
-
S
E
---
F
E
--
G
F
E
Y
------
463
Blastp_CBE
55.22
39%
-62
- C2 -
-
3ION
9.4
-
PDPK1_HUMAN
A:
[34-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
-
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
VL
S
----------------
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
-----
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
N
E
----
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
-
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
--
P
P
---------------------------------------------------------------------
67
Blastp_CBE
55.19
46%
-25
- C2 -
-
3A8W
6.7
-
KPCI_HUMAN
B:
[3-341]
---------------------------------------------------------------------------------------------------------------------------------------------------
M
D
P
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
---
K
K
---
T
-
D
----
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
--
D
-
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
---
A
S
---
N
-
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
--
E
G
---
G
-
D
T
-
T
--
S
-
F
-
C
--
G
T
P
N
Y
I
A
P
E
I
L
R
G
-----
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
DI-------------E---
D
---
Y
L
F
Q
V
I
--
L
--
E
K
Q
I
--
R
I
P
-----
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
------
H
-
P
-
Q
T
G
F
A
D
-
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
--
P
-----
N
I
S
G
E
F
G
L
D
N
F
D
-
S
Q
F
T
N
E
P
V
Q
L
--
P
D
D
D
D
I
--
V
R
K
I
D
Q
-
S
E
---
F
E
--
G
F
E
Y
------
87
Blastp_CBE
55.11
47%
-12
- C2 -
-
3WF7
8.1
-
KS6B1_HUMAN
A:
[13-304]
---------------------------------------------------------------------------------------------------------------------------------------------------
P
E
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
RN
A
-
K
D
-
T
A
H
T
K
A
E
R
N
I
L
-
E
---
E
V
---
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
--
E
S
I
H
D
----
V
T
--
H
-
F
-
C
--
G
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
--
G
---
E
N
R
----
K
---
K
T
I
D
K
I
--
L
--
K
C
K
L
--
N
L
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
------
G
-
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
--
P
-----
L
L
Q
--------------------------------------------------------
55
Blastp_CBE
55.11
46%
-35
- C2 -
-
3ZH8
3.1
-
KPCI_HUMAN
C:
[2-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
---
K
K
---
T
-
D
----
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
--
D
-
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
---
A
S
---
N
-
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
--
E
G
L
R
P
G
-
D
T
-
T
--
S
-
F
-
C
--
G
T
P
N
Y
I
A
P
E
I
L
R
G
-----
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
DIVG-----------TE--
D
---
Y
L
F
Q
V
I
--
L
--
E
K
Q
I
--
R
I
P
-----
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
------
H
-
P
-
Q
T
G
F
A
D
-
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
--
P
-----
N
I
-------------
F
T
N
--------
D
D
D
D
I
--
V
R
K
I
D
Q
-
S
E
---
F
E
--
G
F
E
Y
------
68
Blastp_CBE
54.86
46%
-29
- C2 -
-
3A8W
7.3
-
KPCI_HUMAN
A:
[3-341]
---------------------------------------------------------------------------------------------------------------------------------------------------
M
D
P
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
---
K
K
---
T
-
D
----
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
-------
I
D
W
V
Q
T
E
K
H
V
F
E
Q
---
A
S
---
N
-
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
--
E
G
L
R
P
G
-
D
T
-
T
--
S
-
F
-
C
--
G
T
P
N
Y
I
A
P
E
I
L
R
G
-----
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
DI-------------E---
D
---
Y
L
F
Q
V
I
--
L
--
E
K
Q
I
--
R
I
P
-----
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
------
H
-
P
-
Q
T
G
F
A
D
-
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
--
P
-----
N
I
S
G
E
F
G
L
D
N
F
D
-
S
Q
F
T
N
E
P
V
Q
L
--
P
D
D
D
D
I
--
V
R
K
I
D
Q
-
S
E
---
F
E
--
G
F
E
Y
------
56
Blastp_CBE
54.56
46%
-39
- C2 -
-
3ZH8
6.7
-
KPCI_HUMAN
B:
[2-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
---
K
K
---
T
-
D
----
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
--
D
-
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
---
A
S
---
N
-
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
--
E
G
L
R
P
G
-
D
T
-
T
--
S
-
F
-
C
--
G
T
P
N
Y
I
A
P
E
I
L
R
G
-----
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
DIVG-----------TE--
D
---
Y
L
F
Q
V
I
--
L
--
E
K
Q
I
--
R
I
P
-----
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
------
H
-
P
-
Q
T
G
F
A
D
-
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
--
P
-----
N
I
S
G
E
F
---------
F
T
N
--------
D
D
D
D
I
--
V
R
K
I
D
Q
-
S
E
---
F
E
--
G
F
E
Y
------
118
Blastp_CBE
54.30
44%
10
- C2 -
-
4NW6
8.0
-
KS6A3_HUMAN
A:
[20-322]
-----------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
G
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
----
K
I
---
S
-
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
--
V
-
R
D
R
V
-
R
T
K
M
E
R
D
I
L
-
V
---
E
V
---
N
-
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
--
E
S
I
D
H
E
-
K
K
A
Y
--
S
-
F
-
C
--
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
---
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
--
G
---
K
D
R
----
K
---
E
T
M
T
M
I
--
L
--
K
A
K
L
--
G
M
P
-----
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
A
------
G
-
P
-
D
G
V
-
E
E
-
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
--
P
------------
T
F
Y
F
D
-----------------------------------------------
60
Blastp_CBE
54.30
46%
-31
- C2 -
-
5LIH
6.5
-
KPCI_HUMAN
A:
[2-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
---
K
K
---
T
-
D
----
R
I
Y
A
M
K
V
V
K
K
E
L
V
----------
W
V
Q
T
E
K
H
V
F
E
Q
---
A
S
---
N
-
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
--
E
G
L
R
P
G
-
D
T
-
T
--
S
-
F
-
C
--
G
T
P
N
Y
I
A
P
E
I
L
R
G
-----
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
DIV------------NTE-
D
---
Y
L
F
Q
V
I
--
L
--
E
K
Q
I
--
R
I
P
-----
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
------
H
-
P
-
Q
T
G
F
A
D
-
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
--
P
-----
N
I
S
G
E
F
G
L
D
N
F
D
-
S
Q
F
T
N
E
P
V
Q
L
--
P
D
D
D
D
I
--
V
R
K
I
D
Q
-
S
E
---
F
E
--
G
F
E
Y
------
57
Blastp_CBE
54.07
46%
-36
- C2 -
-
3ZH8
7.2
-
KPCI_HUMAN
A:
[2-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
---
K
K
---
T
-
D
----
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
--
D
-
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
---
A
S
---
N
-
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
--
E
G
L
R
P
G
-
D
T
-
T
--
S
-
F
-
C
--
G
T
P
N
Y
I
A
P
E
I
L
R
G
-----
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
DIVG-----------TE--
D
---
Y
L
F
Q
V
I
--
L
--
E
K
Q
I
--
R
I
P
-----
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
------
H
-
P
-
Q
T
G
F
A
D
-
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
--
P
-----
N
I
S
G
E
F
---------
F
T
N
--------
D
D
D
D
I
--
V
R
K
I
D
Q
-
S
E
---
F
E
--
G
F
E
Y
------
119
Blastp_CBE
53.96
44%
13
- C2 -
-
4NW5
7.9
-
KS6A3_HUMAN
A:
[20-322]
-----------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
G
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
----
K
I
---
S
-
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
--
V
-
R
D
R
V
-
R
T
K
M
E
R
D
I
L
-
V
---
E
V
---
N
-
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
--
E
S
I
D
H
E
-
K
K
A
Y
--
S
-
F
-
C
--
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
---
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
--
G
---
K
D
R
----
K
---
E
T
M
T
M
I
--
L
--
K
A
K
L
--
G
M
P
-----
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
A
------
G
-
P
-
D
G
V
-
E
E
-
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
--
P
------------
T
F
Y
F
D
-----------------------------------------------
549
Blastp_CBE
53.85
39%
-75
- C2 -
-
5LVP
4.6
-
PDPK1_HUMAN
D:
[33-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
-
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
S
------------
F
-
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
-----
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
N
E
----
G
---
L
I
F
A
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
-
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
--
P
P
---------------------------------------------------------------------
120
Blastp_CBE
53.72
44%
10
- C2 -
-
4NUS
7.7
-
KS6A3_HUMAN
A:
[20-322]
-----------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
G
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
----
K
I
---
S
-
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
--
V
-
R
D
R
V
-
R
T
K
M
E
R
D
I
L
-
V
---
E
V
---
N
-
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
--
E
S
I
D
H
E
-
K
K
A
Y
--
S
-
F
-
C
--
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
---
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
--
G
---
K
D
R
----
K
---
E
T
M
T
M
I
--
L
--
K
A
K
L
--
G
M
P
-----
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
A
------
G
-
P
-
D
G
V
-
E
E
-
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
--
P
-----
A
------
T
F
Y
F
D
-----------------------------------------------
81
Blastp_CBE
53.64
46%
-25
- C2 -
-
5LI1
6.8
-
KPCI_HUMAN
A:
[7-342]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
---
K
K
---
T
-
D
----
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
--
D
-
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
---
A
S
---
N
-
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
--
E
G
L
R
P
G
-
D
T
-
T
--
S
-
F
-
C
--
G
T
P
N
Y
I
A
P
E
I
L
R
G
-----
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
DIV------------E---
D
---
Y
L
F
Q
V
I
--
L
--
E
K
Q
I
--
R
I
P
-----
R
-
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
------
H
-
P
-
Q
T
G
F
A
D
-
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
--
P
-----
N
I
S
G
E
F
G
L
D
N
F
D
-
S
Q
F
T
N
E
P
V
Q
L
--
P
D
D
D
D
I
--
V
R
K
I
D
Q
-
S
E
---
F
E
--
G
F
E
Y
------
515
Blastp_CBE
53.62
39%
-78
- C2 -
-
5HO7
3.5
-
PDPK1_HUMAN
A:
[31-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
-
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
S
P
---------
N
-
F
-
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
-----
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
N
E
----
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
-
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
--
P
P
---------------------------------------------------------------------
107
Blastp_CBE
53.43
46%
-6
- C2 -
-
4OTH
7.4
-
A:
[6-319]
---------------------------------------------------------------------------------------------------------------------------------------------------
K
S
P
L
T
L
E
D
F
K
F
L
A
V
L
G
R
G
-
H
F
G
K
V
L
L
S
E
F
---
R
P
---
S
-
G
----
E
L
F
A
I
K
A
L
K
K
G
D
I
V
--
A
-
R
D
E
V
E
S
L
M
C
E
K
R
I
L
-
A
AVT
S
A
---
G
-
H
P
F
L
V
N
L
F
G
C
F
Q
T
P
E
H
V
C
F
V
M
E
Y
S
A
G
G
D
L
M
L
H
I
H
S
--
D
-
V
F
S
E
P
R
A
I
F
Y
S
A
C
V
V
L
G
L
Q
F
L
H
E
-
H
-
K
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
-
T
E
G
Y
V
K
I
A
D
F
G
L
C
K
---------------------------------------------------
T
R
A
V
D
W
W
G
L
G
V
L
L
Y
E
M
L
V
G
-
E
S
P
F
-----
P
--
G
---
D
D
E
----
E
---
E
V
F
D
S
I
--
V
--
N
D
E
V
--
R
Y
P
-----
R
F
L
S
A
E
A
I
G
I
M
R
R
L
L
R
R
N
P
E
R
--
R
L
G
S
------
S
-
E
-
R
D
A
-
E
D
-
V
K
K
Q
P
F
F
R
T
L
G
---
W
E
A
L
L
A
R
R
L
P
P
P
F
V
--
P
-----
T
L
S
G
R
T
D
V
S
N
F
D
-
E
E
F
T
G
E
A
P
T
L
P
P
R
D
--------------------------------
108
Blastp_CBE
53.40
46%
-22
- C2 -
-
4OTG
8.5
-
A:
[6-319]
---------------------------------------------------------------------------------------------------------------------------------------------------
K
S
P
L
T
L
E
D
F
K
F
L
A
V
L
G
R
G
-
H
F
G
K
V
L
L
S
E
F
---
R
P
---
S
-
G
----
E
L
F
A
I
K
A
L
K
K
G
D
I
V
--
A
-
R
D
E
V
E
S
L
M
C
E
K
R
I
L
-
A
AVT
S
A
---
G
-
H
P
F
L
V
N
L
F
G
C
F
Q
T
P
E
H
V
C
F
V
M
E
Y
S
A
G
G
D
L
M
L
H
I
H
S
--
D
-
V
F
S
E
P
R
A
I
F
Y
S
A
C
V
V
L
G
L
Q
F
L
H
E
-
H
-
K
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
-
T
E
G
Y
V
K
I
A
D
F
G
L
C
K
--
E
G
M
G
Y
G
--
D
R
T
--
S
-
F
-
C
--
G
T
P
E
F
L
A
P
E
V
L
T
D
-----
T
---
S
-----
Y
T
R
A
V
D
W
W
G
L
G
V
L
L
Y
E
M
L
V
G
-
E
S
P
F
-----
P
--
G
---
D
D
E
----
E
---
E
V
F
D
S
I
--
V
--
N
D
E
V
--
R
Y
P
-----
R
F
L
S
A
E
A
I
G
I
M
R
R
L
L
R
R
N
P
E
R
--
R
L
G
S
------
S
-
E
-
R
D
A
-
E
D
-
V
K
K
Q
P
F
F
R
T
L
G
---
W
E
A
L
L
A
R
R
L
P
P
P
F
V
--
P
-----
T
L
S
-------------
T
G
E
A
P
T
L
P
P
R
D
--------------------------------
106
Blastp_CBE
53.33
46%
-7
- C2 -
-
4OTI
6.0
-
A:
[6-319]
---------------------------------------------------------------------------------------------------------------------------------------------------
K
S
P
L
T
L
E
D
F
K
F
L
A
V
L
G
R
G
-
H
F
G
K
V
L
L
S
E
F
---
R
P
---
S
-
G
----
E
L
F
A
I
K
A
L
K
K
G
D
I
V
--
A
-
R
D
E
V
E
S
L
M
C
E
K
R
I
L
-
A
AVT
S
A
---
G
-
H
P
F
L
V
N
L
F
G
C
F
Q
T
P
E
H
V
C
F
V
M
E
Y
S
A
G
G
D
L
M
L
H
I
H
S
--
D
-
V
F
S
E
P
R
A
I
F
Y
S
A
C
V
V
L
G
L
Q
F
L
H
E
-
H
-
K
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
-
T
E
G
Y
V
K
I
A
D
F
G
L
-----------------------------------------------------
T
R
A
V
D
W
W
G
L
G
V
L
L
Y
E
M
L
V
G
-
E
S
P
F
-----
P
--
G
---
D
D
E
----
E
---
E
V
F
D
S
I
--
V
--
N
D
E
V
--
R
Y
P
-----
R
F
L
S
A
E
A
I
G
I
M
R
R
L
L
R
R
N
P
E
R
--
R
L
G
S
------
S
-
E
-
R
D
A
-
E
D
-
V
K
K
Q
P
F
F
R
T
L
G
---
W
E
A
L
L
A
R
R
L
P
P
P
F
V
--
P
-----
T
L
S
G
R
T
D
V
S
N
F
D
-
E
E
F
T
G
E
A
P
T
L
P
P
R
D
--------------------------------
517
Blastp_CBE
53.08
39%
-73
- C2 -
-
5HKM
7.3
-
PDPK1_HUMAN
A:
[31-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
-
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
S
------------
F
-
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
-----
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
N
E
----
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
-
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
--
P
P
---------------------------------------------------------------------
514
Blastp_CBE
52.92
39%
-71
- C2 -
-
5HO8
6.4
-
PDPK1_HUMAN
A:
[31-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
-
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
S
----------
N
-
F
-
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
-----
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
N
E
----
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
-
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
--
P
P
---------------------------------------------------------------------
448
Blastp_CBE
52.71
37%
-18
- C2 -
-
6BDL
3.1
-
B:
[29-326]
----------------------------------------------------------------------------------------------------------------------------------------------------
A
N
L
K
L
S
D
F
N
I
I
D
T
L
G
V
G
-
G
F
G
R
V
E
L
V
Q
L
---
K
S
---
E
E
S
----
K
T
F
A
M
K
I
L
K
K
R
H
I
V
--
D
-
T
R
Q
Q
E
H
I
R
S
E
K
Q
I
M
-
Q
---
G
A
---
H
-
S
D
F
I
V
R
L
Y
R
T
F
K
D
S
K
Y
L
Y
M
L
M
E
A
C
L
G
G
E
L
W
T
I
L
R
D
--
R
G
S
F
E
D
S
T
T
R
F
Y
T
A
C
V
V
E
A
F
A
Y
L
H
S
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
L
I
L
D
-
H
R
G
Y
A
K
L
V
D
F
G
F
A
K
--
K
---
I
G
-
F
G
K
K
--
T
W
F
-
C
--
G
T
P
E
Y
V
A
P
E
I
I
L
N
-----
K
---
G
-----
H
D
I
S
A
D
Y
W
S
L
G
I
L
M
Y
E
L
L
T
G
-
S
P
P
F
-----
S
--
G
---
P
D
P
----
M
---
K
T
Y
N
I
I
--
L
RG
I
D
M
I
--
E
F
P
-----
K
K
I
A
K
N
A
A
N
L
I
K
K
L
C
R
D
N
P
S
E
--
R
L
G
N
------
L
-
K
-
N
G
V
-
K
D
-
I
Q
K
H
K
W
F
E
G
F
N
---
W
E
G
L
R
K
G
T
L
T
P
P
I
I
--
P
-----
S
V
A
S
P
T
D
T
S
N
F
D
-----------------------------------------------
110
Blastp_CBE
52.13
45%
3
- C2 -
-
5D9K
7.0
-
KS6A3_HUMAN
A:
[26-323]
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
----
K
I
---
S
-
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
--
V
-
R
D
R
V
-
R
T
K
M
E
R
D
I
L
-
V
---
E
V
---
N
-
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
-------------------
C
--
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
---
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
--
G
---
K
D
R
----
K
---
E
T
M
T
M
I
--
L
--
K
A
K
L
--
G
M
P
-----
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
A
------
G
-
P
-
D
G
V
-
E
E
-
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
--
P
-----
A
------
T
F
Y
F
D
-
P
---------------------------------------------
516
Blastp_CBE
52.12
39%
-75
- C2 -
-
5HNG
4.5
-
PDPK1_HUMAN
A:
[31-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
-
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
S
P
---------
N
-
F
-
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
-----
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
N
E
----
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
-
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
--
P
P
---------------------------------------------------------------------
61
Blastp_CBE
51.92
46%
-26
- C2 -
-
6ILZ
4.3
-
KPCI_HUMAN
G:
[11-341]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
----------
D
----
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
--
D
-
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
---
A
S
---
N
-
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
--
E
G
L
R
P
G
-
D
T
-
T
--
S
-
F
-
C
--
G
T
P
N
Y
I
A
P
E
I
L
R
G
-----
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
DIV----------------
D
---
Y
L
F
Q
V
I
--
L
--
E
K
Q
I
--
R
I
P
-----
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
------
H
-
P
-
Q
T
G
F
A
D
-
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
--
P
-----
N
I
S
---
G
L
D
N
F
D
-
S
Q
F
T
--
P
V
Q
L
--
P
D
D
D
D
I
--
V
R
K
I
D
Q
-
S
E
---
F
E
--
G
F
E
Y
------
117
Blastp_CBE
51.88
44%
12
- C2 -
-
5D9L
5.2
-
KS6A3_HUMAN
A:
[20-322]
-----------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
G
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
----
K
I
---
S
-
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
--
V
-
R
D
R
V
-
R
T
K
M
E
R
D
I
L
-
V
---
E
V
---
N
-
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
--
E
-------------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
---
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
--
G
---
K
D
R
----
K
---
E
T
M
T
M
I
--
L
--
K
A
K
L
--
G
M
P
-----
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
A
------
G
-
P
-
D
G
V
-
E
E
-
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
--
P
-----
A
T
G
R
P
E
D
T
F
Y
F
D
-----------------------------------------------
102
Blastp_CBE
51.72
46%
-37
- C2 -
-
1XJD
7.1
-
A:
[16-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
D
F
I
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
F
---
K
K
---
T
-
N
----
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
--
M
-
D
D
D
V
E
C
T
M
V
E
K
R
V
L
-
S
---
L
A
W--
E
-
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
--
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
-
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
K
--
E
N
M
L
-
G
-
D
A
K
T
--
N
-
F
-
C
--
G
T
P
D
Y
I
A
P
E
I
L
L
G
-----
Q
---
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
-
Q
S
P
F
-----
H
--
G
---
Q
D
E
----
E
---
E
L
F
H
S
I
--
R
--
M
D
N
P
--
F
Y
P
-----
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
G
V
------------
R
-
G
D
-
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
-------------------
N
F
D
-
K
E
F
L
-------
F
A
---------------------------------
59
Blastp_CBE
51.65
46%
-20
- C2 -
-
5LIH
6.0
-
KPCI_HUMAN
B:
[2-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
---
K
K
---
T
-
D
----
R
I
Y
A
M
K
V
V
K
K
E
L
------------
V
Q
T
E
K
H
V
F
E
Q
---
A
S
---
N
-
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
--
E
G
L
R
P
G
-
D
T
-
T
--
S
-
F
-
C
--
G
T
P
N
Y
I
A
P
E
I
L
R
G
-----
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
DI-------------E---
D
---
Y
L
F
Q
V
I
--
L
--
E
K
Q
I
--
R
I
P
-----
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
------
H
-
P
-
Q
T
G
F
A
D
-
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
--
P
-----
N
I
S
G
E
F
G
L
D
N
F
D
-
S
Q
F
T
N
E
P
V
Q
L
--
P
D
D
D
D
I
--
V
R
K
I
D
Q
-
S
E
---
F
E
--
G
F
E
Y
------
449
Blastp_CBE
51.32
37%
-13
- C2 -
-
6BDL
3.0
-
KGP1_HUMAN
A:
[29-326]
----------------------------------------------------------------------------------------------------------------------------------------------------
A
N
L
K
L
S
D
F
N
I
I
D
T
L
G
V
G
-
G
F
G
R
V
E
L
V
Q
L
---
K
S
---
E
E
S
----
K
T
F
A
M
K
I
L
K
K
R
H
I
V
--
D
-
T
R
Q
Q
E
H
I
R
S
E
K
Q
I
M
-
Q
---
G
A
---
H
-
S
D
F
I
V
R
L
Y
R
T
F
K
D
S
K
Y
L
Y
M
L
M
E
A
C
L
G
G
E
L
W
T
I
L
R
D
--
R
G
S
F
E
D
S
T
T
R
F
Y
T
A
C
V
V
E
A
F
A
Y
L
H
S
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
L
I
L
D
-
H
R
G
Y
A
K
L
V
D
F
G
F
A
K
--
K
---
I
G
-
F
G
K
K
--
T
W
F
-
C
--
G
T
P
E
Y
V
A
P
E
I
I
L
N
-----
K
---
G
-----
H
D
I
S
A
D
Y
W
S
L
G
I
L
M
Y
E
L
L
T
G
-
S
P
P
F
-----
S
--
G
---
P
D
P
----
M
---
K
T
Y
N
I
I
--
L
RG
I
D
M
I
--
E
F
P
-----
K
K
I
A
K
N
A
A
N
L
I
K
K
L
C
R
D
N
P
S
E
--
R
L
G
N
------
L
-
K
-
N
G
V
-
K
D
-
I
Q
K
H
K
W
F
E
G
F
N
---
W
E
G
L
R
K
G
T
L
T
P
P
I
I
--
P
-----
S
V
A
S
P
T
D
T
S
N
F
D
-----------------------------------------------
546
Blastp_CBE
51.30
39%
-60
- C2 -
-
4XX9
6.2
-
PDPK1_HUMAN
A:
[32-307]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
-
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
S
P
E
S
-
K
Q
A
R
A-
N
-
F
-
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
-----
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
N
E
----
G
---
L
I
F
A
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
-
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
--
P
P
---------------------------------------------------------------------
64
Blastp_CBE
51.26
46%
-24
- C2 -
-
6ILZ
3.9
-
KPCI_HUMAN
A:
[11-341]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
----------
D
----
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
--
D
-
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
---
A
S
---
N
-
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
--
E
G
L
R
P
G
-
D
T
-
T
--
S
-
F
-
C
--
G
T
P
N
Y
I
A
P
E
I
L
R
G
-----
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
DIV----------------
D
---
Y
L
F
Q
V
I
--
L
--
E
K
Q
I
--
R
I
P
-----
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
------
H
-
P
-
Q
T
G
F
A
D
-
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
--
P
-----
N
I
S
G
E
F
G
L
D
N
F
D
-
S
Q
F
T
N
E
P
V
Q
L
--
P
D
D
D
D
I
--
V
R
K
I
D
Q
-
S
E
---
F
E
--
G
F
E
Y
------
109
Blastp_CBE
51.07
45%
5
- C2 -
-
5D9K
6.6
-
KS6A3_HUMAN
B:
[26-323]
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
----
K
I
---
S
-
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
--
V
-
R
D
R
V
-
R
T
K
M
E
R
D
I
L
-
V
---
E
V
---
N
-
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
--
E
----------------
C
--
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
---
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
--
G
---
K
D
R
----
K
---
E
T
M
T
M
I
--
L
--
K
A
K
L
--
G
M
P
-----
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
A
------
G
-
P
-
D
G
V
-
E
E
-
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
--
P
------------
T
F
Y
F
D
-
P
---------------------------------------------
443
Blastp_CBE
50.95
37%
-11
- C2 -
-
6C0T
6.1
-
A:
[29-326]
----------------------------------------------------------------------------------------------------------------------------------------------------
A
N
L
K
L
S
D
F
N
I
I
D
T
L
G
V
G
-
G
F
G
R
V
E
L
V
Q
L
---
K
S
---
E
E
S
----
K
T
F
A
M
K
I
L
K
K
R
H
I
V
--
D
-
T
R
Q
Q
E
H
I
R
S
E
K
Q
I
M
-
Q
---
G
A
---
H
-
S
D
F
I
V
R
L
Y
R
T
F
K
D
S
K
Y
L
Y
M
L
M
E
A
C
L
G
G
E
L
W
T
I
L
R
D
--
R
G
S
F
E
D
S
T
T
R
F
Y
T
A
C
V
V
E
A
F
A
Y
L
H
S
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
L
I
L
D
-
H
R
G
Y
A
K
L
V
D
F
G
F
A
K
--
K
---
I
G
-
F
G
K
K
--
T
W
F
-
C
--
G
T
P
E
Y
V
A
P
E
I
I
L
N
-----
K
---
G
-----
H
D
I
S
A
D
Y
W
S
L
G
I
L
M
Y
E
L
L
T
G
-
S
P
P
F
-----
S
--
G
---
P
D
P
----
M
---
K
T
Y
N
I
I
--
L
RG
I
D
M
I
--
E
F
P
-----
K
K
I
A
K
N
A
A
N
L
I
K
K
L
C
R
D
N
P
S
E
--
R
L
G
N
------
L
-
K
-
N
G
V
-
K
D
-
I
Q
K
H
K
W
F
E
G
F
N
---
W
E
G
L
R
K
G
T
L
T
P
P
I
I
--
P
-----
S
V
A
S
P
T
D
T
S
N
F
D
-----------------------------------------------
63
Blastp_CBE
50.70
46%
-26
- C2 -
-
6ILZ
4.3
-
KPCI_HUMAN
C:
[11-341]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
----------
D
----
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
--
D
-
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
---
A
S
---
N
-
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
--
E
G
L
R
P
G
-
D
T
-
T
--
S
-
F
-
C
--
G
T
P
N
Y
I
A
P
E
I
L
R
G
-----
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
DI-----------------
D
---
Y
L
F
Q
V
I
--
L
--
E
K
Q
I
--
R
I
P
-----
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
------
H
-
P
-
Q
T
G
F
A
D
-
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
--
P
-----
N
I
S
G
E
F
G
L
D
N
F
D
-
S
Q
F
--
E
P
V
Q
L
--
P
D
D
D
D
I
--
V
R
K
I
D
Q
-
S
E
---
F
E
--
G
F
E
Y
------
435
Blastp_CBE
50.37
42%
12
- C2 -
-
6G78
6.7
-
KS6A6_HUMAN
B:
[9-307]
-------------------------------------------------------------------------------------------------------------------------------------
V
V
K
E
I
P
I
T
HH
V
K
E
G
Y
E
K
A
D
P
A
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
---
K
T
GPD
A
-
G
----
Q
L
Y
A
M
K
V
L
K
K
A
S
L
K
--
V
-
R
D
---------
D
I
L
-
V
---
E
V
---
N
-
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
--
E
V
L
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
-
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
I
G
H
I
K
L
T
D
F
G
L
S
K
--
E
S
V
-----------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
---
G
-----
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
--
G
---
K
D
R
----
N
---
E
T
M
N
M
I
--
L
--
K
A
K
L
--
G
M
P
-----
Q
F
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
S
----------
E
G
V
-
E
E
-
I
K
R
H
L
F
F
A
N
I
D
---
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
--
P
----------------------------------------------------------------
84
Blastp_CBE
50.02
47%
1
- C2 -
-
3A62
9.3
-
KS6B1_HUMAN
A:
[13-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
----------------
K
A
E
R
N
I
L
-
E
---
E
V
---
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
--
E
--------------
F
-
C
--
G
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
--
G
---
E
N
R
----
K
---
K
T
I
D
K
I
--
L
--
K
C
K
L
--
N
L
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
------
G
-
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
--
P
-----
L
----------------------------------------------------------
469
Blastp_CBE
49.97
39%
-56
- C2 -
-
1H1W
5.2
-
PDPK1_HUMAN
A:
[11-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
-
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
S
P
-----
A
R
A-
N
-
F
-
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
-----
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
N
E
----
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
-
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
--
P
P
---------------------------------------------------------------------
125
Blastp_CBE
49.82
44%
11
- C2 -
-
3UBD
7.3
-
KS6A3_MOUSE
A:
[14-304]
-----------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
G
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
----
K
I
---
S
-
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
--
V
-
R
D
R
V
-------
D
I
L
-
V
---
E
V
---
N
-
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
-------
E
-
K
K
A
Y
--
S
-
F
-
C
--
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
---
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
--
G
---
K
D
R
----
K
---
E
T
M
T
M
I
--
L
--
K
A
K
L
--
G
M
P
-----
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
A
------
G
-
P
-
D
G
V
-
E
E
-
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
--
P
----------------------------------------------------------------
425
Blastp_CBE
49.62
42%
19
- C2 -
-
6G77
8.2
-
KS6A6_HUMAN
B:
[9-307]
-------------------------------------------------------------------------------------------------------------------------------------
V
V
K
E
I
P
I
T
HH
V
K
E
G
Y
E
K
A
D
P
A
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
---
K
T
GPD
A
-
G
----
Q
L
Y
A
M
K
V
L
K
K
A
S
L
K
--
V
-
R
D
---------
D
I
L
-
V
---
E
V
---
N
-
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
--
E
V
L
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
-
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
I
G
H
I
K
L
T
D
F
G
L
S
K
--
E
S
V
D
Q
E
-
K
K
A
Y
--
S
-
F
-
C
--
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
---
G
-----
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
--
G
---
K
D
R
----
N
---
E
T
M
N
M
I
--
L
--
K
A
K
L
--
G
M
P
-----
Q
F
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
S
----------
E
G
V
-
E
E
-
I
K
R
H
L
F
F
A
N
I
D
---
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
--
P
----------------------------------------------------------------
114
Blastp_CBE
49.62
43%
3
- C2 -
-
2Z7Q
5.1
-
KS6A1_HUMAN
A:
[24-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
A
D
P
S
H
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
---
V
T
RPD
S
-
G
----
H
L
Y
A
M
K
V
L
----------------------
I
L
-
A
---
D
V
---
N
-
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
--
E
-------------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
Q
---
G
-----
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
-
S
L
P
F
-----
Q
--
G
---
K
D
R
----
K
---
E
T
M
T
L
I
--
L
--
K
A
K
L
--
G
M
P
-----
Q
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
--
R
L
G
S
------
G
-
P
-
D
G
A
-
E
E
-
I
K
R
H
V
F
Y
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
--
P
----------------------------------------------------------------
112
Blastp_CBE
49.60
43%
2
- C2 -
-
2Z7S
6.6
-
KS6A1_HUMAN
A:
[24-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
A
D
P
S
H
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
---
V
T
RPD
S
-
G
----
H
L
Y
A
M
K
V
L
K
---------------------
I
L
-
A
---
D
V
---
N
-
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
--
E
-------------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
Q
---
G
-----
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
-
S
L
P
F
-----
Q
--
G
---
K
D
R
----
K
---
E
T
M
T
L
I
--
L
--
K
A
K
L
--
G
M
P
-----
Q
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
--
R
L
G
S
------
G
-
P
-
D
G
A
-
E
E
-
I
K
R
H
V
F
Y
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
--
P
----------------------------------------------------------------
126
Blastp_CBE
49.58
44%
14
- C2 -
-
4GUE
7.5
-
KS6A3_MOUSE
A:
[15-305]
-----------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
G
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
----
K
I
---
S
-
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
--
V
-
R
D
R
V
---------
L
-
V
---
E
V
---
N
-
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
-------
E
-
K
K
A
Y
--
S
-
F
-
C
--
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
---
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
--
G
---
K
D
R
----
K
---
E
T
M
T
M
I
--
L
--
K
A
K
L
--
G
M
P
-----
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
A
------
G
-
P
-
D
G
V
-
E
E
-
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
--
P
----------------------------------------------------------------
426
Blastp_CBE
49.47
42%
18
- C2 -
-
6G77
7.1
-
KS6A6_HUMAN
A:
[9-307]
-------------------------------------------------------------------------------------------------------------------------------------
V
V
K
E
I
P
I
T
HH
V
K
E
G
Y
E
K
A
D
P
A
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
---
K
T
GPD
A
-
G
----
Q
L
Y
A
M
K
V
L
K
K
A
S
L
K
--
V
-
R
D
---------
D
I
L
-
V
---
E
V
---
N
-
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
--
E
V
L
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
-
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
I
G
H
I
K
L
T
D
F
G
L
S
K
--
E
S
V
D
Q
E
-
K
K
A
Y
--
S
-
F
-
C
--
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
---
G
-----
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
--
G
---
K
D
R
----
N
---
E
T
M
N
M
I
--
L
--
K
A
K
L
--
G
M
P
-----
Q
F
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
S
----------
E
G
V
-
E
E
-
I
K
R
H
L
F
F
A
N
I
D
---
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
--
P
----------------------------------------------------------------
62
Blastp_CBE
49.43
46%
-25
- C2 -
-
6ILZ
5.5
-
KPCI_HUMAN
E:
[12-341]
------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
----------
D
----
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
--
D
-
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
---
A
S
---
N
-
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
--
E
G
L
R
P
G
-
D
T
-
T
--
S
-
F
-
C
--
G
T
P
N
Y
I
A
P
E
I
L
R
G
-----
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
DI-----------------
D
---
Y
L
F
Q
V
I
--
L
--
E
K
Q
I
--
R
I
P
-----
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
------
H
-
P
-
Q
T
G
F
A
D
-
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
--
P
-----
N
I
S
G
E
F
G
L
D
N
F
D
-
S
Q
F
T
--
P
V
Q
L
--
P
D
D
D
D
I
--
V
R
K
I
D
Q
-
S
E
---
F
E
--
G
F
E
Y
------
468
Blastp_CBE
49.42
39%
-56
- C2 -
-
1UVR
3.5
-
PDPK1_HUMAN
A:
[11-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
-
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
S
P
-----
A
R
A-
N
-
F
-
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
-----
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
N
E
----
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
-
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
--
P
P
---------------------------------------------------------------------
111
Blastp_CBE
49.11
45%
9
- C2 -
-
3G51
7.5
-
KS6A3_MOUSE
A:
[14-304]
-----------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
G
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
----
K
I
---
S
-
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
--
V
-----------
R
D
I
L
-
V
---
E
V
---
N
-
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
--
E
S
I
------------------
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
---
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
--
G
---
K
D
R
----
K
---
E
T
M
T
M
I
--
L
--
K
A
K
L
--
G
M
P
-----
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
A
------
G
-
P
-
D
G
V
-
E
E
-
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
--
P
----------------------------------------------------------------
536
Blastp_CBE
48.77
39%
-57
- C2 -
-
3RWQ
6.8
-
PDPK1_HUMAN
A:
[33-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
-
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
---
R
L
---
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
S
P
-----
A
R
A-
N
-
F
-
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
-----
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
N
E
----
Y
---
L
I
F
Q
K
I
--
I
--
K
L
E
Y
--
D
F
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
-
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
--
P
P
---------------------------------------------------------------------
127
Blastp_CBE
48.60
44%
17
- C2 -
-
4EL9
6.8
-
KS6A3_MOUSE
A:
[15-305]
-----------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
G
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
----
K
I
---
S
-
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
--
V
-
R
D
R
V
------
R
D
I
L
-
V
---
E
V
---
N
-
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
--
E
S
---
E
-
K
K
A
Y
--
S
-
F
-
C
--
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
---
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
--
G
---
K
D
R
----
K
---
E
T
M
T
M
I
--
L
--
K
A
K
L
--
G
M
P
-----
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
A
------
G
-
P
-
D
G
V
-
E
E
-
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
--
P
----------------------------------------------------------------
436
Blastp_CBE
48.57
42%
21
- C2 -
-
6G78
8.5
-
KS6A6_HUMAN
A:
[9-307]
-------------------------------------------------------------------------------------------------------------------------------------
V
V
K
E
I
P
I
T
HH
V
K
E
G
Y
E
K
A
D
P
A
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
---
K
T
GPD
A
-
G
----
Q
L
Y
A
M
K
V
L
K
K
A
S
L
K
--
V
-
R
D
---------
D
I
L
-
V
---
E
V
---
N
-
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
--
E
V
L
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
-
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
I
G
H
I
K
L
T
D
F
G
L
S
K
--
E
S
V
D
Q
---------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
---
G
-----
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
--
G
---
K
D
R
----
N
---
E
T
M
N
M
I
--
L
--
K
A
K
L
--
G
M
P
-----
Q
F
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
S
----------
E
G
V
-
E
E
-
I
K
R
H
L
F
F
A
N
I
D
---
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
--
P
----------------------------------------------------------------
89
Blastp_CBE
48.56
47%
-3
- C2 -
-
3WF5
6.7
-
KS6B1_HUMAN
A:
[15-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
--------------
T
K
A
E
R
N
I
L
-
E
---
E
V
---
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
--
E
S
I
H
D
G
--
T
V
T
--
H
-
F
-
C
--
G
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
--
G
---
E
N
R
----
K
---
K
T
I
D
K
I
--
L
--
K
C
K
L
--
N
L
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
------
G
-
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
--
P
-----
L
L
Q
S
-------------------------------------------------------
86
Blastp_CBE
48.32
47%
0
- C2 -
-
3WF8
7.5
-
KS6B1_HUMAN
A:
[15-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
RN
A
-
K
D
-
T
A
H
T
K
A
E
R
N
I
L
-
E
---
E
V
---
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
--
E
S
I
H
D
G
--
T
V
T
--
H
-
F
-
C
--
G
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
--
G
---
E
N
R
----
K
---
K
T
I
D
K
I
--
L
--
K
C
K
L
--
N
L
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
------
G
-
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
--
P
-----
L
L
---------------------------------------------------------
88
Blastp_CBE
48.07
47%
-3
- C2 -
-
3WF6
6.5
-
KS6B1_HUMAN
A:
[15-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
--------------
T
K
A
E
R
N
I
L
-
E
---
E
V
---
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
--
E
S
I
H
D
G
--
T
V
T
--
H
-
F
-
C
--
G
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
--
G
---
E
N
R
----
K
---
K
T
I
D
K
I
--
L
--
K
C
K
L
--
N
L
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
------
G
-
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
--
P
-----
L
L
Q
S
-------------------------------------------------------
113
Blastp_CBE
47.40
43%
14
- C2 -
-
2Z7R
7.5
-
KS6A1_HUMAN
A:
[21-308]
--------------------------------------------------------------------------------------------------------------------------------------------------
G
S
E
K
A
D
P
S
H
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
---
V
T
RPD
S
-
G
----
H
L
Y
A
M
K
V
L
K
K
A
T
L
K
--
V
-------------
I
L
-
A
---
D
V
---
N
-
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
--
E
-------------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
Q
---
G
-----
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
-
S
L
P
F
-----
Q
--
G
---
K
D
R
----
K
---
E
T
M
T
L
I
--
L
--
K
A
K
L
--
G
M
P
-----
Q
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
--
R
L
G
S
------
G
-
P
-
D
G
A
-
E
E
-
I
K
R
H
V
F
Y
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
--
P
----------------------------------------------------------------
85
Blastp_CBE
47.40
47%
1
- C2 -
-
3WF9
7.4
-
KS6B1_HUMAN
A:
[15-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
RN
A
-
K
D
-
T
A
H
T
K
A
E
R
N
I
L
-
E
---
E
V
---
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
--
E
S
I
H
D
G
--
T
V
T
--
H
-
F
-
C
--
G
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
--
G
---
E
N
R
----
K
---
K
T
I
D
K
I
--
L
--
K
C
K
L
--
N
L
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
------
G
-
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
--
P
-----
L
L
---------------------------------------------------------
74
Blastp_CBE
47.24
47%
15
- C2 -
-
3A60
9.1
-
KS6B1_HUMAN
B:
[13-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
--------------------------------
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
--
E
S
---------------
C
--
G
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
--
G
---
E
N
R
----
K
---
K
T
I
D
K
I
--
L
--
K
C
K
L
--
N
L
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
------
G
-
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
--
P
-----
L
----------------------------------------------------------
75
Blastp_CBE
47.23
47%
8
- C2 -
-
3A60
8.6
-
KS6B1_HUMAN
A:
[13-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
A
M
-------------
K
A
E
R
N
I
L
-
E
---
E
V
---
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
--
E
--------------------
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
--
G
---
E
N
R
----
K
---
K
T
I
D
K
I
--
L
--
K
C
K
L
--
N
L
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
------
G
-
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
--
P
----------------------------------------------------------------
437
Blastp_CBE
46.63
42%
4
- C2 -
-
6G76
6.8
-
KS6A6_HUMAN
B:
[9-307]
-------------------------------------------------------------------------------------------------------------------------------------
V
V
K
E
I
P
I
T
HH
V
K
E
G
Y
E
K
A
D
P
A
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
---
K
T
GPD
A
-
G
----
Q
L
Y
A
M
K
V
L
K
K
A
S
L
K
--
V
-----------
R
D
I
L
-
V
---
E
V
---
N
-
H
P
F
I
V
K
L
H
Y
A
F
Q
T
--
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
--
E
V
L
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
-
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
I
G
H
I
K
L
T
D
F
G
L
S
K
--
E
S
V
-
D
-----------------
V
E
Y
M
A
P
E
V
V
N
R
-----
R
---
G
-----
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
--
G
---
K
D
R
----
N
---
E
T
------------
L
--
G
M
P
-----
Q
F
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
S
----------
E
G
V
-
E
E
-
I
K
R
H
L
F
F
A
N
I
D
---
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
--
P
----------------------------------------------------------------
73
Blastp_CBE
46.62
47%
12
- C2 -
-
3A61
7.5
-
KS6B1_HUMAN
A:
[15-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
-----------------
K
A
E
R
N
I
L
-
E
---
E
V
---
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
-------------------------
G
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
--
G
---
E
N
R
----
K
---
K
T
I
D
K
I
--
L
--
K
C
K
L
--
N
L
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
------
G
-
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
--
P
----------------------------------------------------------------
438
Blastp_CBE
44.74
42%
18
- C2 -
-
6G76
5.8
-
KS6A6_HUMAN
A:
[9-307]
-------------------------------------------------------------------------------------------------------------------------------------
V
V
K
E
I
P
I
T
HH
V
K
E
G
Y
E
K
A
D
P
A
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
---
K
T
GPD
A
-
G
----
Q
L
Y
A
M
K
V
L
K
K
A
S
L
K
--
V
-
R
D
---------
D
I
L
-
V
---
E
V
---
N
-
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
--
E
V
L
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
-
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
I
G
H
I
K
L
T
D
F
G
L
S
K
--
E
S
V
-
D
Q
-
E
K
K
A
--
Y
-
F
-
C
--
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
---
G
-----
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
--
G
---
K
D
R
----
N
---
E
T
M
N
M
I
--
L
--
K
A
K
L
--
G
M
P
-----
Q
F
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
S
----------
E
G
V
-
E
E
-
I
K
R
H
L
F
F
A
N
I
D
---
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
--
P
----------------------------------------------------------------
104
Blastp_CBE
44.34
49%
20
- C2 -
-
4RLO
9.0
-
KS6B1_HUMAN
B:
[7-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
--------------------------------
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
--
E
S
I
------------------
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
--
G
---
E
N
R
----
K
---
K
T
I
D
K
I
--
L
--
K
C
K
L
--
N
L
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
------
G
-
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
--
P
----------------------------------------------------------------
-
* C *
-
:
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
:
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
:
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
:
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------