@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Screening
Virtual Screening Score
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : AKT3_HUMAN: (2020-09-04 )
MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNERRPHFPQFSYSASGRE
Atome Classification :
(447 SA)
.........10........20........30.........40......-..50........60........70........80........90........100.......110--..-----.......120.......130.......----140....--.----.-----...150.....-..160.....---..---170----........180...--....190........200---.-.---.-.---....210.......220.......230.......--240.......250.......260..-..--...270.......280........290..--..-...-300...--.-..--..310.......320--.-----..-.....330.......340-....-----.--.---.----350--.---.-----......--360-----.--....-----..---.370.......380.....--..390-----..-...-..-.400.......---410.......420..-----.....430...--....440.......450.......460.....---..470.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(pKd)
(pKd)
(Uniprot)
MS
D
V
T
I
V
K
E
G
W
V
Q
K
R
G
E
Y
I
K
NWR
P
R
Y
F
L
L
K-TDGSFIGYKEKPQDVDL-PYPLNNF
S
V
A
K
C
Q
L
MKTERPKP
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
TFHVDT
P
E
E
R
E
E
W
T
E
A
I
Q
A
V
A
D
R
L
Q
----
R
Q
-----
E
E
E
RMNCSP
T
S
Q
I
DNI
G
E
E
EMDASTTH----H--KRKT--M----
N
-----
D
F
D
Y
L
K
L
LGKG-TFG
K
V
I
L
V
R
E---KA---S-G----
K
Y
Y
A
M
K
I
L
K
K
E
V
I
I--
A
K
D
E
V
A
-
H
T
L
T
E
S
R
V
L-K---N-T---R-H---P
F
L
T
S
L
K
Y
SFQTKD
R
L
C
F
V
M
E
YVNG
G
E
L
F
F
H
L
S
R
--
E
RVFSE
D
R
T
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
HS-G
K
--
I
V
Y
R
D
L
K
L
E
N
L
M
LD-KDG
H
I
K
I
T
D
F
G
L
C
K--EG-IT
D
-
A
-
A
T
M
K
--
T
-FC--G
T
P
E
Y
L
A
P
E
VLEDN---D-----YG-R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
CG-RLPF-----Y--N---Q----
D
H
---
E
---
K
-----
L
F
E
L
I
L
--
M
E------D--IKFP-----R
T
---
L
S
S
D
A
K
S
L
L
S
G
LLIKDPNK--RLGG------G
P
-
D
D
A
-
K
E
-
I
M
R
H
S
FFSGV
N
---
W
Q
D
V
YDKKLVPPFKP-----QVTSETDTRYF--DEEFTA
Q
T
I
T
ITPPEKYDEDGMDCMDNERRPH---FPQFSYSASGRE
4
PsiBlast_PDB
86.57
82%
-49
- C1 -
-
6HHG
-
-
AKT1_HUMAN
A:
[3-444]
--
D
V
A
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
K
T
W
R
P
R
Y
F
L
L
K
-
N
D
G
T
F
I
G
Y
K
E
R
P
Q
D
----
E
A
P
L
N
N
F
S
V
A
Q
C
Q
L
M
K
T
E
R
P
R
P
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
T
F
H
V
E
T
P
E
E
R
E
E
W
T
T
A
I
Q
T
V
A
D
G
L
K
----
K
-----------------------------------------
R
V
T
--
M
----
N
-----
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
--------------------------
S
---
R
-
H
---
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
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E
Y
A
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G
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E
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F
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H
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S
R
--
E
R
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S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
-
I
K
-----
T
M
K
--
T
-
F
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
-
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
----
D
H
---
E
---
K
-----
L
F
E
L
I
L
--
M
E
------
E
--
I
R
F
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
--
D
E
E
F
T
A
-----------------------------------------
10
PsiBlast_PDB
84.89
82%
-49
- C1 -
-
6S9X
-
-
?
A:
[3-443]
--
D
V
A
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
K
T
W
R
P
R
Y
F
L
L
K
-
N
D
G
T
F
I
G
Y
K
E
R
P
Q
D
----
E
A
P
L
N
N
F
S
V
A
Q
C
Q
L
M
K
T
E
R
P
R
P
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
T
F
H
V
E
T
P
E
E
R
E
E
W
T
T
A
I
Q
T
V
A
D
G
L
K
----------------------------------------------
R
V
T
--
M
----
N
-----
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
--------------------
Q
---
N
-
S
---
R
-
H
---
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
-
I
K
------------
F
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
-
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
----
D
H
---
E
---
K
-----
L
F
E
L
I
L
--
M
E
------
E
--
I
R
F
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
--
D
E
E
F
T
------------------------------------------
5
PsiBlast_PDB
84.20
82%
-47
- C1 -
-
6HHH
-
-
AKT1_HUMAN
A:
[2-439]
-
S
D
V
A
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
K
T
W
R
P
R
Y
F
L
L
K
-
N
D
G
T
F
I
G
Y
K
E
R
P
Q
D
V
---
E
A
P
L
N
N
F
S
V
A
Q
C
Q
L
M
K
T
E
R
P
R
P
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
T
F
H
V
E
T
P
E
E
R
E
E
W
T
T
A
I
Q
T
V
A
D
G
L
K
----
K
-----------------------------------------
R
V
T
--
M
----
N
-----
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
-----------------
R
V
L
-
Q
---
N
-
S
---
R
-
H
---
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
-------------------
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
-
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
----
D
H
---
E
---
K
-----
L
F
E
L
I
L
--
M
E
------
E
--
I
R
F
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
--
D
----------------------------------------------
8
PsiBlast_PDB
83.58
82%
-60
- C1 -
-
6HHF
-
-
AKT1_HUMAN
A:
[3-439]
--
D
V
A
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
K
T
W
R
P
R
Y
F
L
L
K
-
N
D
G
T
F
I
G
Y
K
E
R
P
--------
P
L
N
N
F
S
V
A
Q
C
Q
L
M
K
T
E
R
P
R
P
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
T
F
H
V
E
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P
E
E
R
E
E
W
T
T
A
I
Q
T
V
A
D
G
L
K
----
K
Q
-----------------------------------------
V
T
--
M
----
N
-----
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
--------------------------
S
---
R
-
H
---
P
F
L
T
A
L
K
Y
S
F
Q
T
H
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R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
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R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
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A
L
D
Y
L
H
S
-
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
------------------------
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
-
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
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L
P
F
-----
Y
--
N
---
Q
----
D
H
---
E
---
K
-----
L
F
E
L
I
L
--
M
E
------
E
--
I
R
F
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
--
D
----------------------------------------------
3
PsiBlast_PDB
83.18
82%
-57
- C1 -
-
4EJN
-
-
AKT1_HUMAN
A:
[4-438]
---
V
A
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
K
T
W
R
P
R
Y
F
L
L
K
-
N
D
G
T
F
I
G
Y
K
E
R
P
-------
A
P
L
N
N
F
S
V
A
Q
C
Q
L
M
K
T
E
R
P
R
P
N
T
F
I
I
R
C
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W
T
T
V
I
E
R
T
F
H
V
E
T
P
E
E
R
E
E
W
T
T
A
I
Q
T
V
A
D
G
------------------------------------------------
R
V
T
--
M
----
N
-----
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
----------------
V
L
-
Q
---
N
-
S
---
R
-
H
---
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
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F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
-
I
K
-------
K
--
T
-
F
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
-
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
----
D
H
---
E
---
K
-----
L
F
E
L
I
L
--
M
E
------
E
--
I
R
F
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
-------------------------------------------------
1
PsiBlast_PDB
82.84
83%
-63
- C1 -
-
3O96
-
-
AKT1_HUMAN
A:
[5-432]
-
S
D
V
A
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
K
T
W
R
P
R
Y
F
L
L
K
-
N
D
G
T
F
I
G
Y
K
E
R
P
Q
D
V
---
E
A
P
L
N
N
F
S
V
A
Q
C
Q
L
M
K
T
E
R
P
R
P
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
T
F
---
T
P
E
E
R
E
E
W
T
T
A
I
Q
T
V
A
D
G
L
K
----
K
Q
-----------------------------------------
V
T
--
M
----
N
-----
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
-----------
N
R
V
L
-
Q
---
N
-
S
---
R
-
H
---
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
----------------------
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
-
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
----
D
H
---
E
---
K
-----
L
F
E
L
I
L
--
M
E
------
E
--
I
R
F
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
-----
Q
V
----------------------------------------------------------
37
Blastp_CBE
82.63
83%
-108
- C1 -
-
3D0E
9.2
-
AKT2_HUMAN
B:
[3-335]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
----
N
-----
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
K
D
E
V
A
-
H
T
V
T
E
S
R
V
L
-
Q
---
N
-
T
---
R
-
H
---
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
--
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
-
I
S
D
-
G
-
A
T
M
K
--
T
-
F
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
-
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
----
D
H
---
E
---
R
-----
L
F
E
L
I
L
--
M
E
------
E
--
I
R
F
P
-----
R
T
---
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
P
-
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
-----
Q
V
T
S
E
V
D
T
R
Y
F
--
D
D
E
F
T
A
Q
S
I
T
I
-
P
P
D
------------
D
Q
R
T
H
---
F
P
Q
F
D
Y
S
A
S
I
R
-
36
Blastp_CBE
82.56
83%
-108
- C1 -
-
3E87
6.8
-
AKT2_HUMAN
A:
[3-335]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
----
N
-----
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
K
D
E
V
A
-
H
T
V
T
E
S
R
V
L
-
Q
---
N
-
T
---
R
-
H
---
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
--
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
-
I
S
D
-
G
-
A
T
M
K
--
T
-
F
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
-
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
----
D
H
---
E
---
R
-----
L
F
E
L
I
L
--
M
E
------
E
--
I
R
F
P
-----
R
T
---
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
P
-
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
-----
Q
V
T
S
E
V
D
T
R
Y
F
--
D
D
E
F
T
A
Q
S
I
T
I
-
P
P
-------------
D
Q
R
T
H
---
F
P
Q
F
D
Y
S
A
S
I
R
-
33
Blastp_CBE
82.36
83%
-112
- C1 -
-
3E88
9.5
-
AKT2_HUMAN
B:
[3-335]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
----
N
-----
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
K
D
E
V
A
-
H
T
V
T
E
S
R
V
L
-
Q
---
N
-
T
---
R
-
H
---
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
--
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
-
I
S
D
-
G
-
A
T
M
K
--
T
-
F
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
-
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
----
D
H
---
E
---
R
-----
L
F
E
L
I
L
--
M
E
------
E
--
I
R
F
P
-----
R
T
---
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
P
-
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
-----
Q
V
T
S
E
V
D
T
R
Y
F
--
D
D
E
F
T
A
Q
S
I
T
I
----------------
D
Q
R
T
H
---
F
P
Q
F
D
Y
S
A
S
I
R
-
7
PsiBlast_PDB
82.30
82%
6
- C1 -
-
6HHJ
-
-
AKT1_HUMAN
A:
[3-444]
--
D
V
A
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
K
T
W
R
P
R
Y
F
L
L
K
-
N
D
G
T
F
I
G
Y
K
E
R
P
Q
--
D
Q
R
E
A
P
L
N
N
F
S
V
A
Q
C
Q
L
M
K
T
E
R
P
R
P
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
T
F
H
V
E
T
P
E
E
R
E
E
W
T
T
A
I
Q
T
V
A
D
G
L
K
----
K
Q
----------------------------------------
R
V
T
--
M
----
N
-----
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
K
D
E
V
A
-
H
T
L
T
E
N
R
V
L
-
Q
---
N
-
S
---
R
-
H
---
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
-
I
K
D
-
G
-
A
T
M
K
--
T
-
F
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
-
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
----
D
H
---
E
---
K
-----
L
F
E
L
I
L
--
M
E
------
E
--
I
R
F
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
--
D
E
E
F
T
A
-----------------------------------------
35
Blastp_CBE
82.12
83%
-108
- C1 -
-
3E87
7.0
-
AKT2_HUMAN
B:
[3-335]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
----
N
-----
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
K
D
E
V
A
-
H
T
V
T
E
S
R
V
L
-
Q
---
N
-
T
---
R
-
H
---
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
--
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
-
I
S
D
-
G
-
A
T
M
K
--
T
-
F
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
-
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
----
D
H
---
E
---
R
-----
L
F
E
L
I
L
--
M
E
------
E
--
I
R
F
P
-----
R
T
---
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
P
-
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
-----
Q
V
T
S
E
V
D
T
R
Y
F
--
D
D
E
F
T
A
Q
S
I
T
I
-
P
P
-------------
D
Q
R
T
H
---
F
P
Q
F
D
Y
S
A
S
I
R
-
30
Blastp_CBE
81.99
83%
-113
- C1 -
-
1O6K
7.9
-
AKT2_HUMAN
A:
[3-334]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
----
N
-----
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
K
D
E
V
A
-
H
T
V
T
E
S
R
V
L
-
Q
---
N
-
T
---
R
-
H
---
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
--
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
-
I
S
D
-
G
-
A
T
M
K
--
T
-
F
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
-
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
----
D
H
---
E
---
R
-----
L
F
E
L
I
L
--
M
E
------
E
--
I
R
F
P
-----
R
T
---
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
P
-
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
-----
Q
V
T
S
E
V
D
T
R
Y
F
--
D
D
E
F
T
A
Q
S
I
T
------------------
Q
R
T
H
---
F
P
Q
F
D
Y
S
A
S
I
--
38
Blastp_CBE
81.97
83%
-110
- C1 -
-
3D0E
9.2
-
AKT2_HUMAN
A:
[3-335]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
----
N
-----
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
K
D
E
V
A
-
H
T
V
T
E
S
R
V
L
-
Q
---
N
-
T
---
R
-
H
---
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
--
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
-
I
S
D
-
G
-
A
T
M
K
--
T
-
F
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
-
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
----
D
H
---
E
---
R
-----
L
F
E
L
I
L
--
M
E
------
E
--
I
R
F
P
-----
R
T
---
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
P
-
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
-----
Q
V
T
S
E
V
D
T
R
Y
F
--
D
D
E
F
T
A
Q
S
I
T
I
-
P
P
D
------------
D
Q
R
T
H
---
F
P
Q
F
D
Y
S
A
S
I
R
-
34
Blastp_CBE
81.95
83%
-112
- C1 -
-
3E88
9.3
-
AKT2_HUMAN
A:
[3-335]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
----
N
-----
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
K
D
E
V
A
-
H
T
V
T
E
S
R
V
L
-
Q
---
N
-
T
---
R
-
H
---
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
--
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
-
I
S
D
-
G
-
A
T
M
K
--
T
-
F
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
-
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
----
D
H
---
E
---
R
-----
L
F
E
L
I
L
--
M
E
------
E
--
I
R
F
P
-----
R
T
---
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
P
-
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
-----
Q
V
T
S
E
V
D
T
R
Y
F
--
D
D
E
F
T
A
Q
S
I
T
I
----------------
D
Q
R
T
H
---
F
P
Q
F
D
Y
S
A
S
I
R
-
31
Blastp_CBE
81.63
83%
-113
- C1 -
-
3E8D
8.8
-
AKT2_HUMAN
B:
[3-335]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
----
N
-----
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
K
D
E
V
A
-
H
T
V
T
E
S
R
V
L
-
Q
---
N
-
T
---
R
-
H
---
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
--
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
-
I
S
D
-
G
-
A
T
M
K
--
T
-
F
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
-
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
----
D
H
---
E
---
R
-----
L
F
E
L
I
L
--
M
E
------
E
--
I
R
F
P
-----
R
T
---
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
P
-
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
-----
Q
V
T
S
E
V
D
T
R
Y
F
--
D
D
E
F
T
A
Q
S
I
-------------------
Q
R
T
H
---
F
P
Q
F
D
Y
S
A
S
I
R
-
32
Blastp_CBE
81.46
83%
-114
- C1 -
-
3E8D
8.4
-
AKT2_HUMAN
A:
[3-335]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
----
N
-----
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
K
D
E
V
A
-
H
T
V
T
E
S
R
V
L
-
Q
---
N
-
T
---
R
-
H
---
P
F
L
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A
L
K
Y
A
F
Q
T
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D
R
L
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F
V
M
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Y
A
N
G
G
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L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
--
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
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K
I
T
D
F
G
L
C
K
--
E
G
-
I
S
D
-
G
-
A
T
M
K
--
T
-
F
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
-
R
A
V
D
W
W
G
L
G
V
V
M
Y
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M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
----
D
H
---
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---
R
-----
L
F
E
L
I
L
--
M
E
------
E
--
I
R
F
P
-----
R
T
---
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
P
-
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
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I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
-----
Q
V
T
S
E
V
D
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Y
F
--
D
D
E
F
T
A
Q
S
I
---------------------
T
H
---
F
P
Q
F
D
Y
S
A
S
I
R
-
547
Fugue
81.41
87%
-59
- C1 -
-
5KCV
9.2
-
AKT1_HUMAN
A:
[20-452]
-----
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
-
T
W
R
P
R
Y
F
L
L
K
-
N
D
G
T
F
I
G
Y
K
E
R
P
A
-------
P
L
N
N
F
S
V
A
Q
C
Q
L
M
K
T
E
R
P
R
P
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
T
F
H
V
E
T
P
E
E
R
E
E
W
T
T
A
I
Q
-----------------------------------------------------
R
V
T
--
M
----
N
-----
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
--------------------
V
L
-
Q
---
N
-
S
---
R
-
H
---
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
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R
--
E
R
V
F
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D
R
A
R
F
Y
G
A
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I
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A
L
D
Y
L
H
S
-
E
K
N-
V
V
Y
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D
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L
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N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
--------------------------
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
-
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
----
D
H
---
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---
K
-----
L
F
E
L
I
L
--
M
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------
E
--
I
R
F
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
-------------------------------------------------
566
HHSearch
80.96
82%
-111
- C1 -
-
2JDO
6.3
-
AKT2_HUMAN
A:
[7-341]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
--
M
----
N
-----
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
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K
V
I
L
V
R
E
---
K
A
---
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----
R
Y
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---
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T
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--
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V
Y
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L
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G
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--
E
G
-
I
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D
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G
-
A
T
M
K
--
T
-
F
C
--
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T
P
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Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
-
R
A
V
D
W
W
G
L
G
V
V
M
Y
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M
M
C
G
-
R
L
P
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-----
Y
--
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---
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----
D
H
---
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---
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-----
L
F
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L
I
L
--
M
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------
E
--
I
R
F
P
-----
R
T
---
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
P
-
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D
A
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E
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V
M
E
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R
F
F
L
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---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
-----
Q
V
T
S
E
V
D
T
R
Y
F
--
D
D
E
F
T
A
Q
S
I
T
---------------------
M
---
F
E
D
F
D
Y
I
A
D
---
45
Blastp_CBE
80.87
82%
-112
- C1 -
-
2JDO
6.3
-
AKT2_HUMAN
A:
[8-340]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
----
N
-----
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
K
D
E
V
A
-
H
T
V
T
E
S
R
V
L
-
Q
---
N
-
T
---
R
-
H
---
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
--
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
-
I
S
D
-
G
-
A
T
M
K
--
T
-
F
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
-
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
----
D
H
---
E
---
R
-----
L
F
E
L
I
L
--
M
E
------
E
--
I
R
F
P
-----
R
T
---
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
P
-
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
-----
Q
V
T
S
E
V
D
T
R
Y
F
--
D
D
E
F
T
A
Q
S
I
T
---------------------
M
---
F
E
D
F
D
Y
I
A
----
41
Blastp_CBE
80.66
82%
-117
- C1 -
-
2XH5
8.6
-
AKT2_HUMAN
A:
[8-340]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
----
N
-----
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
K
D
E
V
A
-
H
T
V
T
E
S
R
V
L
-
Q
---
N
-
T
---
R
-
H
---
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
--
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
-
I
S
D
-
G
-
A
T
M
K
--
T
-
F
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
-
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
----
D
H
---
E
---
R
-----
L
F
E
L
I
L
--
M
E
------
E
--
I
R
F
P
-----
R
T
---
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
P
-
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
-----
Q
V
T
S
E
V
D
T
R
Y
F
--
D
D
E
F
T
A
Q
S
I
T
-------------------
Q
E
M
---
F
E
D
F
D
Y
I
A
----
40
Blastp_CBE
80.65
82%
-115
- C1 -
-
1O6L
7.9
-
AKT2_HUMAN
A:
[3-335]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
----
N
-----
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
K
D
E
V
A
-
H
T
V
T
E
S
R
V
L
-
Q
---
N
-
T
---
R
-
H
---
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
--
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
-
I
S
D
-
G
-
A
T
M
K
--
T
-
F
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
-
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
----
D
H
---
E
---
R
-----
L
F
E
L
I
L
--
M
E
------
E
--
I
R
F
P
-----
R
T
---
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
P
-
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
-----
Q
V
T
S
E
V
D
T
R
Y
F
--
D
D
E
F
T
A
Q
S
I
T
-------------------
Q
E
M
---
F
E
D
F
D
Y
I
A
----
43
Blastp_CBE
80.50
82%
-110
- C1 -
-
2UW9
6.6
-
AKT2_HUMAN
A:
[8-340]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
----
N
-----
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
K
D
E
V
A
-
H
T
V
T
E
S
R
V
L
-
Q
---
N
-
T
---
R
-
H
---
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
--
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
-
I
S
D
-
G
-
A
T
M
K
--
T
-
F
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
-
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
----
D
H
---
E
---
R
-----
L
F
E
L
I
L
--
M
E
------
E
--
I
R
F
P
-----
R
T
---
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
P
-
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
-----
Q
V
T
S
E
V
D
T
R
Y
F
--
D
D
E
F
T
A
Q
S
I
T
-------------------
Q
E
M
---
F
E
D
F
D
Y
I
A
----
44
Blastp_CBE
80.34
82%
-112
- C1 -
-
2JDR
8.9
-
AKT2_HUMAN
A:
[8-340]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
----
N
-----
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
K
D
E
V
A
-
H
T
V
T
E
S
R
V
L
-
Q
---
N
-
T
---
R
-
H
---
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
--
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
-
I
S
D
-
G
-
A
T
M
K
--
T
-
F
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
-
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
----
D
H
---
E
---
R
-----
L
F
E
L
I
L
--
M
E
------
E
--
I
R
F
P
-----
R
T
---
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
P
-
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
-----
Q
V
T
S
E
V
D
T
R
Y
F
--
D
D
E
F
T
A
Q
S
I
T
-------------------
Q
E
M
---
F
E
D
F
D
Y
I
A
----
42
Blastp_CBE
80.11
82%
-112
- C1 -
-
2X39
7.8
-
AKT2_HUMAN
A:
[8-340]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
----
N
-----
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
K
D
E
V
A
-
H
T
V
T
E
S
R
V
L
-
Q
---
N
-
T
---
R
-
H
---
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
--
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
-
I
S
D
-
G
-
A
T
M
K
--
T
-
F
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
-
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
----
D
H
---
E
---
R
-----
L
F
E
L
I
L
--
M
E
------
E
--
I
R
F
P
-----
R
T
---
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
P
-
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
-----
Q
V
T
S
E
V
D
T
R
Y
F
--
D
D
E
F
T
A
Q
S
I
T
-------------------
Q
E
M
---
F
E
D
F
D
Y
I
A
----
564
HHSearch
78.75
80%
8
- C1 -
-
6S9W
9.4
-
?
A:
[3-444]
--
D
V
A
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
K
T
W
R
P
R
Y
F
L
L
K
N
D
G
T
F
I
G
Y
K
E
R
P
Q
D
V
D
Q
R
-
E
A
P
L
N
N
F
S
V
A
Q
C
Q
L
M
K
T
E
R
P
R
P
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
T
F
H
V
E
T
P
E
E
R
E
E
W
T
T
A
I
Q
T
V
A
D
G
L
K
----
K
-------------------------------------
K
--
H
R
V
T
--
M
----
N
-----
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
K
D
E
V
A
-
H
T
L
T
E
N
R
V
L
-
Q
---
N
-
S
---
R
-
H
---
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
--
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
-
I
K
----
A
T
M
K
--
T
-
F
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
-
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
----
D
H
---
E
---
K
-----
L
F
E
L
I
L
--
M
E
------
E
--
I
R
F
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
--
D
E
E
F
T
A
-----------------------------------------
565
HHSearch
75.79
80%
13
- C1 -
-
6S9X
11.2
-
?
A:
[3-443]
--
D
V
A
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
K
T
W
R
P
R
Y
F
L
L
K
N
D
G
T
F
I
G
Y
K
E
R
P
Q
D
-----
E
A
P
L
N
N
F
S
V
A
Q
C
Q
L
M
K
T
E
R
P
R
P
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
T
F
H
V
E
T
P
E
E
R
E
E
W
T
T
A
I
Q
T
V
A
D
G
L
K
----------------------------------------------
R
V
T
--
M
----
N
-----
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
--------------------
Q
---
N
-
S
---
R
-
H
---
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
--
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
-
I
K
------------
F
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
-
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
----
D
H
---
E
---
K
-----
L
F
E
L
I
L
--
M
E
------
E
--
I
R
F
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
--
D
E
E
F
T
------------------------------------------
20
PsiBlast_PDB
74.04
85%
-24
- C1 -
-
4GV1
7.8
-
AKT1_HUMAN
A:
[4-337]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
--
M
----
N
-----
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
K
D
E
V
A
-
H
T
L
T
E
N
R
V
L
-
Q
---
N
-
S
---
R
-
H
---
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
-
I
K
D
-
G
-
A
T
M
K
--
T
-
F
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
-
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
----
D
H
---
E
---
K
-----
L
F
E
L
I
L
--
M
E
------
E
--
I
R
F
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
--
D
E
E
F
T
A
Q
M
I
T
I
T
P
-------
S
M
E
C
V
D
S
E
R
R
P
H
---
F
P
Q
F
D
Y
S
A
S
---
563
HHSearch
73.82
80%
3
- C1 -
-
4EJN
11.2
-
AKT1_HUMAN
A:
[4-438]
---
V
A
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
K
T
W
R
P
R
Y
F
L
L
K
N
D
G
T
F
I
G
Y
K
E
R
P
--------
A
P
L
N
N
F
S
V
A
Q
C
Q
L
M
K
T
E
R
P
R
P
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
T
F
H
V
E
T
P
E
E
R
E
E
W
T
T
A
I
Q
T
V
A
D
G
------------------------------------------------
R
V
T
--
M
----
N
-----
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
----------------
V
L
-
Q
---
N
-
S
---
R
-
H
---
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
--
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
-
I
K
-------
K
--
T
-
F
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
-
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
----
D
H
---
E
---
K
-----
L
F
E
L
I
L
--
M
E
------
E
--
I
R
F
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
-------------------------------------------------
567
HHSearch
73.80
86%
-24
- C1 -
-
4GV1
7.8
-
AKT1_HUMAN
A:
[7-337]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
----
N
-----
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
K
D
E
V
A
-
H
T
L
T
E
N
R
V
L
-
Q
---
N
-
S
---
R
-
H
---
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
--
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
-
I
K
D
-
G
-
A
T
M
K
--
T
-
F
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
-
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
----
D
H
---
E
---
K
-----
L
F
E
L
I
L
--
M
E
------
E
--
I
R
F
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
--
D
E
E
F
T
A
Q
M
I
T
I
T
P
-----
S
M
--
E
C
V
D
S
E
R
R
P
H
---
F
P
Q
F
D
Y
S
A
S
---
14
PsiBlast_PDB
72.82
85%
-32
- C1 -
-
3QKK
7.4
-
AKT1_HUMAN
A:
[5-338]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
--
M
----
N
-----
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
K
D
E
V
A
-
H
T
L
T
E
N
R
V
L
-
Q
---
N
-
S
---
R
-
H
---
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
-
I
K
D
-
G
-
A
T
M
K
--
T
-
F
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
-
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
----
D
H
---
E
---
K
-----
L
F
E
L
I
L
--
M
E
------
E
--
I
R
F
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
--
D
E
E
F
T
A
Q
M
I
T
I
----------
M
E
C
V
D
S
E
R
R
P
H
---
F
P
Q
F
D
Y
S
A
S
---
16
PsiBlast_PDB
72.66
85%
-26
- C1 -
-
3QKM
9.8
-
AKT1_HUMAN
A:
[5-338]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
--
M
----
N
-----
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
K
D
E
V
A
-
H
T
L
T
E
N
R
V
L
-
Q
---
N
-
S
---
R
-
H
---
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
-
I
K
D
-
G
-
A
T
M
K
--
T
-
F
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
-
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
----
D
H
---
E
---
K
-----
L
F
E
L
I
L
--
M
E
------
E
--
I
R
F
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
--
D
E
E
F
T
A
Q
M
I
T
I
T
P
-------
S
M
E
C
V
D
S
E
R
R
P
H
---
F
P
Q
F
D
Y
S
A
S
---
18
PsiBlast_PDB
72.13
85%
-21
- C1 -
-
4EKL
8.2
-
AKT1_HUMAN
A:
[5-338]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
--
M
----
N
-----
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
K
D
E
V
A
-
H
T
L
T
E
N
R
V
L
-
Q
---
N
-
S
---
R
-
H
---
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
-
I
K
D
-
G
-
A
T
M
K
--
T
-
F
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
-
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
----
D
H
---
E
---
K
-----
L
F
E
L
I
L
--
M
E
------
E
--
I
R
F
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
--
D
E
E
F
T
A
Q
M
I
T
I
T
P
-------
S
M
E
C
V
D
S
E
R
R
P
H
---
F
P
Q
F
D
Y
S
A
S
---
15
PsiBlast_PDB
72.01
85%
-25
- C1 -
-
3QKL
8.7
-
AKT1_HUMAN
A:
[5-338]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
--
M
----
N
-----
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
K
D
E
V
A
-
H
T
L
T
E
N
R
V
L
-
Q
---
N
-
S
---
R
-
H
---
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
-
I
K
D
-
G
-
A
T
M
K
--
T
-
F
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
-
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
----
D
H
---
E
---
K
-----
L
F
E
L
I
L
--
M
E
------
E
--
I
R
F
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
--
D
E
E
F
T
A
Q
M
I
T
-------------------
R
P
H
---
F
P
Q
F
D
Y
S
A
S
---
22
Blastp_CBE
72.00
85%
-27
- C1 -
-
4EKK
6.7
-
AKT1_HUMAN
B:
[5-338]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
--
M
----
N
-----
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
K
D
E
V
A
-
H
T
L
T
E
N
R
V
L
-
Q
---
N
-
S
---
R
-
H
---
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
-
I
K
D
-
G
-
A
T
M
K
--
T
-
F
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
-
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
----
D
H
---
E
---
K
-----
L
F
E
L
I
L
--
M
E
------
E
--
I
R
F
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
--
D
E
E
F
T
A
Q
M
I
-----------------
S
E
R
R
P
H
---
F
P
Q
F
D
Y
S
A
S
---
28
Blastp_CBE
71.69
85%
-25
- C1 -
-
3CQU
8.5
-
AKT1_HUMAN
A:
[6-339]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
--
M
----
N
-----
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
K
D
E
V
A
-
H
T
L
T
E
N
R
V
L
-
Q
---
N
-
S
---
R
-
H
---
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
-
I
K
D
-
G
-
A
T
M
K
--
T
-
F
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
-
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
----
D
H
---
E
---
K
-----
L
F
E
L
I
L
--
M
E
------
E
--
I
R
F
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
--
D
E
E
F
T
A
Q
M
------------------
S
E
R
R
P
H
---
F
P
Q
F
D
Y
S
A
S
---
26
Blastp_CBE
71.40
85%
-25
- C1 -
-
3MV5
6.1
-
AKT1_HUMAN
A:
[6-339]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
--
M
----
N
-----
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
K
D
E
V
A
-
H
T
L
T
E
N
R
V
L
-
Q
---
N
-
S
---
R
-
H
---
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
-
I
K
D
-
G
-
A
T
M
K
--
T
-
F
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
-
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
----
D
H
---
E
---
K
-----
L
F
E
L
I
L
--
M
E
------
E
--
I
R
F
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
--
D
E
E
F
T
A
Q
M
I
--------------------
R
P
H
---
F
P
Q
F
D
Y
S
A
S
---
25
Blastp_CBE
71.33
85%
-26
- C1 -
-
3MVH
7.7
-
AKT1_HUMAN
A:
[7-338]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
--
M
----
N
-----
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
K
D
E
V
A
-
H
T
L
T
E
N
R
V
L
-
Q
---
N
-
S
---
R
-
H
---
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
-
I
K
D
-
G
-
A
T
M
K
--
T
-
F
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
-
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
----
D
H
---
E
---
K
-----
L
F
E
L
I
L
--
M
E
------
E
--
I
R
F
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
--
D
E
E
F
T
A
Q
----------------------
R
P
H
---
F
P
Q
F
D
Y
S
A
----
12
PsiBlast_PDB
71.11
85%
-22
- C1 -
-
3OCB
7.2
-
AKT1_HUMAN
A:
[5-338]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
--
M
----
N
-----
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
K
D
E
V
A
-
H
T
L
T
E
N
R
V
L
-
Q
---
N
-
S
---
R
-
H
---
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
-
I
K
D
-
G
-
A
T
M
K
--
T
-
F
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
-
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
----
D
H
---
E
---
K
-----
L
F
E
L
I
L
--
M
E
------
E
--
I
R
F
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
--
D
E
E
F
T
A
Q
M
---------------------
R
P
H
---
F
P
Q
F
D
Y
S
A
S
---
23
Blastp_CBE
71.09
85%
-27
- C1 -
-
3OW4
6.7
-
AKT1_HUMAN
B:
[5-338]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
--
M
----
N
-----
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
K
D
E
V
A
-
H
T
L
T
E
N
R
V
L
-
Q
---
N
-
S
---
R
-
H
---
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
-
I
K
D
-
G
-
A
T
M
K
--
T
-
F
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
-
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
----
D
H
---
E
---
K
-----
L
F
E
L
I
L
--
M
E
------
E
--
I
R
F
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
--
D
E
E
F
T
A
Q
M
I
T
-------------------
R
P
H
---
F
P
Q
F
D
Y
S
A
S
---
24
Blastp_CBE
71.07
85%
-24
- C1 -
-
3OCB
7.3
-
AKT1_HUMAN
B:
[5-338]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
--
M
----
N
-----
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
K
D
E
V
A
-
H
T
L
T
E
N
R
V
L
-
Q
---
N
-
S
---
R
-
H
---
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
-
I
K
D
-
G
-
A
T
M
K
--
T
-
F
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
-
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
----
D
H
---
E
---
K
-----
L
F
E
L
I
L
--
M
E
------
E
--
I
R
F
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
--
D
E
E
F
T
A
Q
M
I
T
I
T
-----------------
R
P
H
---
F
P
Q
F
D
Y
S
A
S
---
39
Blastp_CBE
70.99
83%
-28
- C1 -
-
6CCY
10.0
-
AKT1_HUMAN
A:
[4-339]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
--
M
----
N
-----
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
K
D
E
V
A
-
H
T
L
T
E
S
R
V
L
-
Q
---
N
-
S
---
R
-
H
---
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
-
I
K
D
-
G
-
A
T
M
K
--
T
-
F
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
-
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
----
D
H
---
E
---
K
-----
L
F
E
L
I
L
--
M
E
------
E
--
I
R
F
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
P
-
S
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
-----
Q
V
T
S
E
V
D
T
R
Y
F
--
D
E
E
F
T
A
Q
M
I
T
I
T
-------------------
E
QEM
F
R
D
F
D
Y
I
A
----
17
PsiBlast_PDB
70.95
85%
-16
- C1 -
-
4EKK
6.7
-
AKT1_HUMAN
A:
[5-338]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
--
M
----
N
-----
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
K
D
E
V
A
-
H
T
L
T
E
N
R
V
L
-
Q
---
N
-
S
---
R
-
H
---
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
-
I
K
D
-
G
-
A
T
M
K
--
T
-
F
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
-
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
----
D
H
---
E
---
K
-----
L
F
E
L
I
L
--
M
E
------
E
--
I
R
F
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
--
D
E
E
F
T
A
Q
M
I
-----------------
S
E
R
R
P
H
---
F
P
Q
F
D
Y
S
A
S
---
27
Blastp_CBE
70.80
85%
-25
- C1 -
-
3CQW
6.5
-
AKT1_HUMAN
A:
[6-339]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
--
M
----
N
-----
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
K
D
E
V
A
-
H
T
L
T
E
N
R
V
L
-
Q
---
N
-
S
---
R
-
H
---
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
-
I
K
D
-
G
-
A
T
M
K
--
T
-
F
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
-
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
----
D
H
---
E
---
K
-----
L
F
E
L
I
L
--
M
E
------
E
--
I
R
F
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
--
D
E
E
F
T
A
Q
M
I
------------------
E
R
R
P
H
---
F
P
Q
F
D
Y
S
A
S
---
13
PsiBlast_PDB
70.75
85%
-22
- C1 -
-
3OW4
7.1
-
AKT1_HUMAN
A:
[5-338]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
--
M
----
N
-----
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
-
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--
A
K
D
E
V
A
-
H
T
L
T
E
N
R
V
L
-
Q
---
N
-
S
---
R
-
H
---
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
-
I
K
D
-
G
-
A
T
M
K
--
T
-
F
C
--
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
-
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
--
N
---
Q
----
D
H
---
E
---
K
-----
L
F
E
L
I
L
--
M
E
------
E
--
I
R
F
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
------
G
S
-
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
--
D
E
E
F
T
A
Q
M
I
T
-------------------
R
P
H
---
F
P
Q
F
D
Y
S
A
S
---
164
Blastp_CBE
65.74
42%
-93
- C1 -
-
2UZT
7.5
-
KAPCA_BOVIN
A:
[11-328]
----------------------------------------------------------------------------------------------------------------------------------------
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
V
-----
K
-
G
R
T
W
--
T
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
D
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
-
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
-------------------------------
161
Blastp_CBE
65.24
42%
-89
- C1 -
-
2UZW
5.5
-
KAPCA_BOVIN
E:
[11-328]
----------------------------------------------------------------------------------------------------------------------------------------
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
V
-----
K
-
G
R
T
W
--
T
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
D
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
-
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
-------------------------------
198
Blastp_CBE
65.05
40%
-88
- C1 -
-
2F7E
7.5
-
KAPCA_BOVIN
E:
[16-343]
------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
----
V
-
K
-
G
R
T
W
--
T
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
-
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
-------------------------------
196
Blastp_CBE
64.94
40%
-94
- C1 -
-
2F7Z
7.7
-
KAPCA_BOVIN
E:
[16-343]
------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
----
V
-
K
-
G
R
T
W
--
T
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
-
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
-------------------------------
162
Blastp_CBE
64.68
42%
-85
- C1 -
-
2UZV
7.6
-
KAPCA_BOVIN
A:
[11-328]
----------------------------------------------------------------------------------------------------------------------------------------
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
V
-----
K
-
G
R
T
W
--
T
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
D
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
-
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
-------------------------------
194
Blastp_CBE
64.59
40%
-88
- C1 -
-
2OJF
6.9
-
KAPCA_BOVIN
E:
[16-343]
------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
----
V
-
K
-
G
R
T
W
--
T
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
-
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
-------------------------------
440
Blastp_CBE
64.50
41%
-96
- C1 -
-
5N23
7.4
-
KAPCA_HUMAN
A:
[26-331]
----------------------------------------------------------------------------------------------------------------------------------------
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
R
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
Q
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
K
--
R
----
V
-
K
-
G
R
T
P
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
------
S
N
F
--
D
D
---------------------------------------------
163
Blastp_CBE
64.26
42%
-87
- C1 -
-
2UZU
6.2
-
KAPCA_BOVIN
E:
[11-328]
----------------------------------------------------------------------------------------------------------------------------------------
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
V
-----
K
-
G
R
T
W
--
T
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
D
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
-
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
-------------------------------
197
Blastp_CBE
63.69
40%
-84
- C1 -
-
2F7X
7.4
-
KAPCA_BOVIN
E:
[16-343]
------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
----
V
-
K
-
G
R
T
W
--
T
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
-
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
-------------------------------
195
Blastp_CBE
63.57
40%
-89
- C1 -
-
2OH0
7.3
-
KAPCA_BOVIN
E:
[16-343]
------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
----
V
-
K
-
G
R
T
W
--
T
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
-
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
-------------------------------
580
HHSearch
60.19
46%
-23
- C1 -
-
5LI9
6.8
-
KPCI_HUMAN
A:
[4-342]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--
L
----
Q
-----
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
---
K
K
---
T
-
D
----
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
--
D
D
E
D
I
D
-
W
V
Q
T
E
K
H
V
F
-
E
---
Q
-
A
S--
N
-
H
---
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
--
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
--
E
G
-
L
R
P
-
G
-
D
T
T
S
--
T
-
F
C
--
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
---
D
-----
Y
G
-
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
-----------------------TED
Y
-----
L
F
Q
V
I
L
--
E
K
------
Q
--
I
R
I
P
-----
R
S
---
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
------
H
P
Q
T
G
F
-
A
D
-
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
-----
N
I
S
G
E
F
G
L
D
N
F
--
D
S
Q
F
T
N
E
P
V
Q
L
T
P
D
D
D
D
I
------
V
R
K
I
D
Q
S
E
---
F
E
G
F
E
Y
I
N
P
L
--
88
Blastp_CBE
59.91
48%
-37
- C1 -
-
4Q9Z
6.1
-
KPCT_HUMAN
A:
[4-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
----
E
-----
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
F
---
K
K
---
T
-
N
----
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
--
M
D
D
D
V
E
-
C
T
M
V
E
K
R
V
L
-
S
---
L
-
A
W--
E
-
H
---
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
--
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
--
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
K
--
E
N
-
M
L
G
-
D
-
A
K
T
N
--
E
-
F
C
--
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
---
K
-----
Y
N
-
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
-
Q
S
P
F
-----
H
--
G
---
Q
----
D
E
---
E
---
E
-----
L
F
H
S
I
R
--
M
D
------
N
--
P
F
Y
P
-----
R
W
---
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
G
V
------
R
G
-
D
------
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
-----
K
V
K
S
P
F
D
C
S
N
F
--
D
K
E
F
L
N
E
----------------------------------------
582
HHSearch
59.85
46%
-28
- C1 -
-
5LI1
7.2
-
KPCI_HUMAN
A:
[7-346]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
--
L
----
Q
-----
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
---
K
K
---
T
-
D
----
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
--
D
D
E
D
I
D
-
W
V
Q
T
E
K
H
V
F
-
E
---
Q
-
A
S--
N
-
H
---
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
--
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
--
E
G
-
L
R
P
-
G
-
D
T
T
S
--
T
-
F
C
--
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
---
D
-----
Y
G
-
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
-----
D
--
I
--------------TED
Y
-----
L
F
Q
V
I
L
--
E
K
------
Q
--
I
R
I
P
-----
R
S
---
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
------
H
P
Q
T
G
F
-
A
D
-
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
-----
N
I
S
G
E
F
G
L
D
N
F
--
D
S
Q
F
T
N
E
P
V
Q
L
T
P
D
D
D
D
I
------
V
R
K
I
D
Q
S
E
---
F
E
G
F
E
Y
I
N
P
L
--
90
Blastp_CBE
59.81
48%
-35
- C1 -
-
5F9E
8.8
-
KPCT_HUMAN
A:
[18-312]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
----
E
-----
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
F
---
K
K
---
T
-
N
----
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
--
M
D
D
D
V
E
-
C
T
M
V
E
K
R
V
L
-
S
---
L
-
A
W--
E
-
H
---
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
--
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
--
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
K
--
E
N
-
M
L
G
-
D
-
A
K
T
N
--
E
-
F
C
--
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
---
K
-----
Y
N
-
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
-
Q
S
P
F
-----
H
--
G
---
Q
----
D
E
---
E
---
E
-----
L
F
H
S
I
R
--
M
D
------
N
--
P
F
Y
P
-----
R
W
---
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
G
V
------
R
G
-
D
------
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
-----
K
V
K
S
P
F
D
C
S
N
F
--
D
K
E
F
L
N
E
----------------------------------------
86
Blastp_CBE
59.24
48%
-37
- C1 -
-
4RA5
6.8
-
KPCT_HUMAN
A:
[4-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
----
E
-----
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
F
---
K
K
---
T
-
N
----
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
--
M
D
D
D
V
E
-
C
T
M
V
E
K
R
V
L
-
S
---
L
-
A
W--
E
-
H
---
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
--
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
--
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
K
--
E
N
-
M
L
G
-
D
-
A
K
T
N
--
E
-
F
C
--
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
---
K
-----
Y
N
-
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
-
Q
S
P
F
-----
H
--
G
---
Q
----
D
E
---
E
---
E
-----
L
F
H
S
I
R
--
M
D
------
N
--
P
F
Y
P
-----
R
W
---
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
G
V
------
R
G
-
D
------
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
-----
K
V
K
S
P
F
D
C
S
N
F
--
D
K
E
F
L
N
E
----------------------------------------
458
Blastp_CBE
59.11
37%
-109
- C1 -
-
2PE2
2.9
-
PDPK1_HUMAN
A:
[2-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
K
R
--
P
----
E
-----
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
-------------
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
Y
---
L
-----
I
F
Q
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
460
Blastp_CBE
58.90
37%
-108
- C1 -
-
2PE0
5.3
-
PDPK1_HUMAN
A:
[2-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
K
R
--
P
----
E
-----
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
-------------
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
Y
---
L
-----
I
F
Q
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
461
Blastp_CBE
58.85
37%
-107
- C1 -
-
1Z5M
6.8
-
PDPK1_HUMAN
A:
[2-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
K
R
--
P
----
E
-----
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
-------------
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
Y
---
L
-----
I
F
Q
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
493
Blastp_CBE
58.66
38%
-119
- C1 -
-
1UU3
8.3
-
PDPK1_HUMAN
A:
[31-306]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
-------------
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
Y
---
L
-----
I
F
Q
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
459
Blastp_CBE
58.56
37%
-108
- C1 -
-
2PE1
6.2
-
PDPK1_HUMAN
A:
[2-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
K
R
--
P
----
E
-----
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
-------------
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
Y
---
L
-----
I
F
Q
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
568
HHSearch
58.47
45%
-27
- C1 -
-
4RA5
6.8
-
KPCT_HUMAN
A:
[3-328]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
I
----
E
-----
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
F
---
K
K
---
T
-
N
----
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
--
M
D
D
D
V
E
-
C
T
M
V
E
K
R
V
L
-
S
L--
A
-
W
---
E
-
H
---
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
--
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
--
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
K
--
E
N
-
M
L
G
-
D
-
A
K
T
N
--
E
-
F
C
--
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
---
K
-----
Y
N
-
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
-
Q
S
P
F
-----
H
--
G
---
Q
----
D
E
---
E
---
E
-----
L
F
H
S
I
R
--
M
D
------
N
--
P
F
Y
P
-----
R
W
---
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
G
V
-----------
R
-
G
D
-
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
-----
K
V
K
S
P
F
D
C
S
N
F
--
D
K
E
F
L
N
E
K
P
R
L
S
F
A
D
R
A
L
------
I
N
S
M
D
Q
N
M
---
F
R
N
F
S
F
M
N
P
G
M
-
85
Blastp_CBE
58.41
48%
-38
- C1 -
-
4RA5
6.2
-
B:
[4-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
----
E
-----
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
F
---
K
K
---
T
-
N
----
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
--
M
D
D
D
V
E
-
C
T
M
V
E
K
R
V
L
-
S
---
L
-
A
W--
E
-
H
---
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
--
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
--
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
K
--
E
N
-
M
L
G
-
D
-
A
K
T
N
--
E
-
F
C
--
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
---
K
-----
Y
N
-
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
-
Q
S
P
F
-----
H
--
G
---
Q
----
D
E
---
E
---
E
-----
L
F
H
S
I
R
--
M
D
------
N
--
P
F
Y
P
-----
R
W
---
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
G
V
------
R
G
-
D
------
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
-----
K
V
K
S
P
F
D
C
S
N
F
--
D
K
E
F
L
N
E
----------------------------------------
550
Fugue
58.40
33%
-25
- C1 -
-
4AW2
2.2
-
MRCKA_RAT
A:
[1-416]
------
S
G
E
V
R
L
R
Q
L
E
Q
F
I
L
D
G
P
A
Q
------
T
N
G
Q
C
F
S
V
E
T
L
L
D
I
L
I
C
-
L
Y
D
E
C
N
N
S
--------------------------------
P
L
R
R
E
K
N
I
L
E
Y
L
E
W
A
K
P
F
T
S
K
V
K
----
Q
M
----------------------------------------
R
L
H
--
R
----
E
-----
D
F
E
I
L
K
V
I
G
R
G
-
A
F
G
E
V
A
V
V
K
L
---
K
N
---
A
-
D
----
K
V
F
A
M
K
I
L
N
K
W
E
M
L
--
K
R
A
E
T
A
-
C
F
R
E
E
R
D
V
L
-
V
---
N
-
G
---
D
-
S
---
K
W
I
T
T
L
H
Y
A
F
Q
D
D
N
N
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F-
E
D
R
L
P
E
E
M
A
R
F
Y
L
A
E
M
V
I
A
I
D
S
V
H
Q
-
L
H
--
Y
V
H
R
D
I
K
P
D
N
I
L
M
D
-
M
N
G
H
I
R
L
A
D
F
G
S
C
L
--
K
L
-
M
E
D
G
T
-
V
Q
S
S
--
V
-
A
V
--
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
---
E
GGKGR
Y
G
-
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
-
E
T
P
F
-----
Y
--
A
---
E
----
S
L
---
V
---
E
-----
T
Y
G
K
I
M
--
N
H
------
K
--
E
R
F
Q
FPTQV
T
D
---
V
S
E
N
A
K
D
L
I
R
R
L
-
I
C
S
R
E
H
--
R
L
G
--------
Q
-
N
G
I
-
E
D
-
F
K
K
H
P
F
F
S
G
I
D
---
W
D
N
I
R
N
C
E
--
A
P
Y
I
P
-----
E
V
S
S
P
T
D
T
S
N
F
--
D
V
-----------------------
D
S
G
H
H
L
P
---
F
V
G
F
T
Y
T
S
S
C
V
L
486
Blastp_CBE
58.17
38%
-115
- C1 -
-
3QCY
8.8
-
PDPK1_HUMAN
A:
[34-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
--------------
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
Y
---
L
-----
I
F
Q
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
87
Blastp_CBE
58.16
48%
-33
- C1 -
-
4Q9Z
5.4
-
B:
[4-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
----
E
-----
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
F
---
K
K
---
T
-
N
----
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
--
M
D
D
D
V
E
-
C
T
M
V
E
K
R
V
L
-
S
---
L
-
A
W--
E
-
H
---
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
--
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
--
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
K
--
E
N
-
M
L
G
-
D
-
A
K
T
N
--
E
-
F
C
--
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
---
K
-----
Y
N
-
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
-
Q
S
P
F
-----
H
--
G
---
Q
----
D
E
---
E
---
E
-----
L
F
H
S
I
R
--
M
D
------
N
--
P
F
Y
P
-----
R
W
---
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
G
V
------
R
G
-
D
------
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
-----
K
V
K
S
P
F
D
C
S
N
F
--
D
K
E
F
L
N
E
----------------------------------------
570
HHSearch
57.93
46%
-33
- C1 -
-
3TXO
6.2
-
KPCL_HUMAN
A:
[23-349]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
N
F
E
F
I
R
V
L
G
K
G
-
S
F
G
K
V
M
L
A
R
V
---
K
E
---
T
-
G
----
D
L
Y
A
V
K
V
L
K
K
D
V
I
L
--
Q
D
D
D
V
E
-
C
T
M
T
E
K
R
I
L
-
S
---
L
-
A
R--
N
-
H
---
P
F
L
T
Q
L
F
C
C
F
Q
T
P
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
--
S
R
R
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
-
K
G
--
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
H
E
G
H
C
K
L
A
D
F
G
M
C
K
--
E
G
-
I
--------------
C
--
G
T
P
D
Y
I
A
P
E
I
L
Q
E
M
---
L
-----
Y
G
-
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
-
H
A
P
F
-----
E
--
A
---
E
----
N
E
---
D
---
D
-----
L
F
E
A
I
L
--
N
D
------
E
--
V
V
Y
P
-----
T
W
---
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
--
R
L
G
S
------
L
T
Q
G
G
E
-
H
A
-
I
L
R
H
P
F
F
K
E
I
D
---
W
A
Q
L
N
H
R
Q
I
E
P
P
F
R
P
-----
R
I
K
S
R
E
D
V
S
N
F
--
D
P
D
F
I
K
E
E
P
V
L
T
P
I
D
E
G
H
------
L
P
M
I
N
Q
D
E
---
F
R
N
F
E
Y
V
S
P
---
501
Blastp_CBE
57.62
38%
-113
- C1 -
-
3QC4
9.8
-
PDPK1_HUMAN
B:
[36-311]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
-----------
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
P
E
-
S
---------
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
Y
---
L
-----
I
F
Q
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
A
A
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
572
HHSearch
57.46
45%
-50
- C1 -
-
1XJD
7.9
-
A:
[16-335]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
----
E
-----
D
F
I
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
F
---
K
K
---
T
-
N
----
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
--
M
D
D
D
V
E
-
C
T
M
V
E
K
R
V
L
-
S
L--
A
-
W
---
E
-
H
---
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
--
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
--
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
K
--
E
N
-
M
L
G
-
D
-
A
K
T
N
--
T
-
F
C
--
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
---
K
-----
Y
N
-
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
-
Q
S
P
F
-----
H
--
G
---
Q
----
D
E
---
E
---
E
-----
L
F
H
S
I
R
--
M
D
------
N
--
P
F
Y
P
-----
R
W
---
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
G
V
-----------
R
-
G
D
-
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
---------------------------------------------------
Q
N
M
---
F
R
N
F
S
F
------
89
Blastp_CBE
57.32
48%
-35
- C1 -
-
5F9E
7.9
-
B:
[18-340]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
----
E
-----
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
F
---
K
K
---
T
-
N
----
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
--
M
D
D
D
V
E
-
C
T
M
V
E
K
R
V
L
-
S
---
L
-
A
W--
E
-
H
---
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
--
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
--
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
K
--
E
N
-
M
L
G
-
D
-
A
K
T
N
--
E
-
F
C
--
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
---
K
-----
Y
N
-
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
-
Q
S
P
F
-----
H
--
G
---
Q
----
D
E
---
E
---
E
-----
L
F
H
S
I
R
--
M
D
------
N
--
P
F
Y
P
-----
R
W
---
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
G
V
------
R
G
-
D
------
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
-----
K
V
K
S
P
F
--
S
N
F
--
D
--
F
L
N
E
----------------------------------------
54
Blastp_CBE
56.91
44%
-36
- C1 -
-
4RA4
7.1
-
KPCA_HUMAN
A:
[15-348]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
V
K
--
L
----
T
-----
D
F
N
F
L
M
V
L
G
K
G
-
S
F
G
K
V
M
L
A
D
R
---
K
G
---
T
-
E
----
E
L
Y
A
I
K
I
L
K
K
D
V
V
I
--
Q
D
D
D
V
E
-
C
T
M
V
E
K
R
V
L
-
A
---
L
-
L
D--
K
-
P
---
P
F
L
T
Q
L
H
S
C
F
Q
T
V
D
R
L
Y
F
V
M
E
Y
V
N
G
G
D
L
M
Y
H
I
Q
Q
--
V
G
K
F
K
E
P
Q
A
V
F
Y
A
A
E
I
S
I
G
L
F
F
L
H
K
-
R
G
--
I
I
Y
R
D
L
K
L
D
N
V
M
L
D
-
S
E
G
H
I
K
I
A
D
F
G
M
C
K
--
E
H
-
M
M
D
-
G
-
V
T
T
R
--
T
-
F
C
--
G
T
P
D
Y
I
A
P
E
I
I
A
Y
Q
---
P
-----
Y
G
-
K
S
V
D
W
W
A
Y
G
V
L
L
Y
E
M
L
A
G
-
Q
P
P
F
-----
D
--
G
---
E
----
D
E
---
D
---
E
-----
L
F
Q
S
I
M
--
E
H
------
N
--
V
S
Y
P
-----
K
S
---
L
S
K
E
A
V
S
I
C
K
G
L
M
T
K
H
P
A
K
--
R
L
G
C
------
G
P
-
E
G
E
-
R
D
-
V
R
E
H
A
F
F
R
R
I
D
---
W
E
K
L
E
N
R
E
I
Q
P
P
F
K
P
-----
K
-------------------
G
Q
P
V
L
P
P
D
Q
L
V
I
A
N
I
D
Q
S
D
F
E
G
F
Y
V
---
N
P
Q
F
V
H
------
502
Blastp_CBE
56.82
38%
-106
- C1 -
-
3QC4
9.7
-
PDPK1_HUMAN
A:
[36-311]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
P
E
-
S
---------
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
Y
---
L
-----
I
F
Q
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
A
A
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
485
Blastp_CBE
56.75
38%
-112
- C1 -
-
3QD0
8.6
-
PDPK1_HUMAN
A:
[34-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
-----------------
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
Y
---
L
-----
I
F
Q
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
48
Blastp_CBE
56.27
49%
-55
- C1 -
-
2R5T
6.8
-
SGK1_HUMAN
A:
[24-320]
--------------------------------------------------------------------------------------------------------------------------------------------
Q
I
N
L
G
P
S
S
N
P
----
H
--
A
K
P
S
-------------
D
F
H
F
L
K
V
I
G
K
G
-
S
F
G
K
V
L
L
A
R
H
---
K
A
---
E
-
E
----
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
----------------
V
L
L
K
---
N
-
V
---
K
-
H
---
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
--
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
--
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
--
E
N
-
I
E
H
-
N
-
S
T
T
S
--
T
-
F
C
--
G
T
P
E
Y
L
A
P
E
V
L
H
K
Q
---
P
-----
Y
D
-
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
-
L
P
P
F
-----
Y
--
S
---
R
----
N
T
---
A
---
E
-----
M
Y
D
N
I
L
--
N
K
------
P
--
L
Q
L
K
-----
P
N
---
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
--
R
L
G
A
------
K
--
D
D
F
-
M
E
-
I
K
S
H
V
F
F
S
L
I
N
---
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
-----
N
V
S
G
--------------------------------------------------------
483
Blastp_CBE
56.16
38%
-111
- C1 -
-
3QD4
8.8
-
PDPK1_HUMAN
A:
[34-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
-----------------
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
Y
---
L
-----
I
F
Q
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
49
Blastp_CBE
56.09
48%
-42
- C1 -
-
3TXO
5.8
-
A:
[23-321]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
N
F
E
F
I
R
V
L
G
K
G
-
S
F
G
K
V
M
L
A
R
V
---
K
E
---
T
-
G
----
D
L
Y
A
V
K
V
L
K
K
D
V
I
L
--
Q
D
D
D
V
E
-
C
T
M
T
E
K
R
I
L
-
S
---
L
-
A
---
R
N
H
---
P
F
L
T
Q
L
F
C
C
F
Q
T
P
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
--
S
R
R
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
-
K
G
--
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
H
E
G
H
C
K
L
A
D
F
G
M
C
K
--
E
G
-
I
--------------
C
--
G
T
P
D
Y
I
A
P
E
I
L
Q
E
M
---
L
-----
Y
G
-
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
-
H
A
P
F
-----
E
--
A
---
E
----
N
E
---
D
---
D
-----
L
F
E
A
I
L
--
N
D
------
E
--
V
V
Y
P
-----
T
W
---
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
--
R
L
G
S
------
L
T
-
Q
G
G
-
E
H
A
I
L
R
H
P
F
F
K
E
I
D
---
W
A
Q
L
N
H
R
Q
I
E
P
P
F
R
P
-----
R
I
K
S
R
E
D
V
S
N
F
--
D
P
D
F
I
K
E
----------------------------------------
47
Blastp_CBE
55.69
49%
-55
- C1 -
-
3HDM
7.1
-
SGK1_HUMAN
A:
[23-320]
-------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
I
N
L
G
P
S
S
N
P
----
H
--
A
K
P
S
-------------
D
F
H
F
L
K
V
I
G
K
G
-
S
F
G
K
V
L
L
A
R
H
---
K
A
---
E
-
E
----
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
----------------
V
L
L
K
---
N
-
V
---
K
-
H
---
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
--
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
--
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
--
E
N
-
I
E
H
-
N
-
S
T
T
S
--
T
-
F
C
--
G
T
P
E
Y
L
A
P
E
V
L
H
K
Q
---
P
-----
Y
D
-
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
-
L
P
P
F
-----
Y
--
S
---
R
----
N
T
---
A
---
E
-----
M
Y
D
N
I
L
--
N
K
------
P
--
L
Q
L
K
-----
P
N
---
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
--
R
L
G
A
------
K
--
D
D
F
-
M
E
-
I
K
S
H
V
F
F
S
L
I
N
---
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
-----
N
V
S
G
--------------------------------------------------------
581
HHSearch
55.53
35%
-54
- C1 -
-
6ED6
7.9
-
ROCK2_HUMAN
A:
[85-413]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
--
A
----
E
-----
D
Y
D
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
H
---
K
A
---
S
-
Q
----
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
--
K
R
S
D
S
A
-
F
F
W
E
E
R
D
I
M
-
A
---
F
-
A
---
N
-
S
---
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
--
Y
-
D
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
--
L
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
H
G
H
L
K
L
A
D
F
G
T
C
M
--
K
M
-
D
E
T
-
G
M
V
H
C
D
--
T
-
A
V
--
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
----F----
Y
G
-
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
-
D
T
P
F
-----
Y
--
A
---
D
----
S
L
---
V
---
G
-----
T
Y
S
K
I
M
--
D
H
------
K
NS
L
C
F
P
ED---
A
E
---
I
S
K
H
A
K
N
L
I
C
A
F
L
T
D
R
E
V
R
LG
R
N
------------
G
V
-
E
E
-
I
R
Q
H
P
F
F
K
N
D
Q
---
W
H
W
D
N
I
R
E
T
A
A
P
V
V
P
-----
E
L
S
S
D
I
D
S
S
N
F
--
D
D
I
-------
E
T
F
P
I
P
K
A
-------
F
V
G
N
Q
L
P
---
F
I
G
F
T
Y
------
46
Blastp_CBE
55.13
49%
-59
- C1 -
-
3HDN
7.0
-
SGK1_HUMAN
A:
[24-316]
--------------------------------------------------------------------------------------------------------------------------------------------
Q
I
N
L
G
P
S
S
N
P
----
H
--
A
K
P
S
-------------
D
F
H
F
L
K
V
I
G
K
G
-
S
F
G
K
V
L
L
A
R
H
---
K
A
---
E
-
E
----
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
----------------
V
L
L
K
---
N
-
V
---
K
-
H
---
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
--
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
--
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
--
E
N
-
I
E
H
-
N
-
S
T
T
S
--
T
-
F
C
--
G
T
P
E
Y
L
A
P
E
V
L
H
K
Q
---
P
-----
Y
D
-
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
-
L
P
P
F
-----
Y
--
S
---
R
----
N
T
---
A
---
E
-----
M
Y
D
N
I
L
--
N
K
------
P
--
L
Q
L
K
-----
P
N
---
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
--
R
L
G
A
------
K
--
D
D
F
-
M
E
-
I
K
S
H
V
F
F
S
L
I
N
---
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
-----------------------------------------------------------------
524
Blastp_CBE
55.06
38%
-80
- C1 -
-
5LVP
5.6
-
PDPK1_HUMAN
C:
[33-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
------------N
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
G
---
L
-----
I
F
A
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
67
Blastp_CBE
55.03
48%
-5
- C1 -
-
4L46
8.2
-
KS6B1_HUMAN
A:
[20-345]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
RN
A
K
D
-
T
A
-
H
T
K
A
E
R
N
I
L
-
E
---
E
-
V
---
K
-
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
--
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
--
E
S
-
I
H
D
------
H
--
T
-
F
C
--
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
---
G
-----
H
N
-
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
--
G
---
E
----
N
R
---
K
---
K
-----
T
I
D
K
I
L
--
K
C
------
K
--
L
N
L
P
-----
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
------
G
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----
L
---
E
E
D
V
S
Q
F
--
D
S
K
F
T
R
Q
T
P
V
D
S
P
----------------------------------
473
Blastp_CBE
54.60
35%
25
- C1 -
-
4AW2
2.2
-
MRCKA_RAT
A:
[12-416]
----------------------------------------------------------------------------------------
F
I
L
D
G
P
A
Q
T
N
G
Q
C
F
S
V
E
T
L
L
D
I
L
I
----
C
L
-----
Y
D
E
-
C
N
N
S
P
L
R
R
E
K
N
I
L
E
Y
L
E
W
A
K
P
F
T
----
S
--
K
V
K
Q
--
M
RLHR
E
-----
D
F
E
I
L
K
V
I
G
R
G
-
A
F
G
E
V
A
V
V
K
L
---
K
N
---
A
-
D
----
K
V
F
A
M
K
I
L
N
K
W
E
M
L
--
K
R
A
E
T
A
-
C
F
R
E
E
R
D
V
L
-
V
---
N
-
G
---
D
-
S
---
K
W
I
T
T
L
H
Y
A
F
Q
D
D
N
N
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F-
E
D
R
L
P
E
E
M
A
R
F
Y
L
A
E
M
V
I
A
I
D
S
V
H
Q
-
L
H
--
Y
V
H
R
D
I
K
P
D
N
I
L
M
D
-
M
N
G
H
I
R
L
A
D
F
G
S
C
L
--
K
L
-
M
E
D
-
G
-
T
V
Q
S
--
S
-
V
A
V-
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
---
E
GGKGR
Y
G
-
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
-
E
T
P
F
-----
Y
--
A
---
E
----
S
L
---
V
---
E
-----
T
Y
G
K
I
M
NH
K
E
------
R
--
F
Q
F
P
-----
T
Q
VTD
V
S
E
N
A
K
D
L
I
R
R
L
I
C
S
R
E
H
R
--
L
G
Q
N
------
G
I
-
E
D
F
-
K
----
K
H
P
F
F
S
G
I
D
---
W
D
N
I
--
R
N
C
E
A
P
Y
I
P
-----
E
V
S
S
P
T
D
T
S
N
F
DV
D
D
D
C
L
K
N
S
E
T
M
P
P
P
---------------------------------
478
Blastp_CBE
54.50
38%
-121
- C1 -
-
5HO8
6.4
-
PDPK1_HUMAN
A:
[31-306]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
------------N
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
Y
---
L
-----
I
F
Q
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
479
Blastp_CBE
54.49
38%
-123
- C1 -
-
5HO7
3.5
-
PDPK1_HUMAN
A:
[31-306]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
P
-----------N
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
Y
---
L
-----
I
F
Q
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
192
Blastp_CBE
54.29
41%
-49
- C1 -
-
1SMH
3.2
-
KAPCA_BOVIN
A:
[2-329]
--------------------------------------------------------------------------------------------------------
N
A
A
A
A
K
K
G
----
S
E
-----
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
E
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
L
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
525
Blastp_CBE
54.17
38%
-116
- C1 -
-
5LVP
5.7
-
PDPK1_HUMAN
B:
[33-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
------------N
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
G
---
L
-----
I
F
A
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
437
Blastp_CBE
54.12
41%
-58
- C1 -
-
4C35
5.9
-
KAPCA_BOVIN
A:
[26-330]
----------------------------------------------------------------------------------------------------------------------------------------
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
Y
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
191
Blastp_CBE
54.11
41%
-42
- C1 -
-
1XHA
9.8
-
KAPCA_BOVIN
A:
[2-329]
--------------------------------------------------------------------------------------------------------
N
A
A
A
A
K
K
G
----
S
E
-----
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
E
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
L
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
480
Blastp_CBE
54.03
38%
-125
- C1 -
-
5HNG
4.6
-
PDPK1_HUMAN
A:
[31-306]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
P
-----------N
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
Y
---
L
-----
I
F
Q
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
283
Blastp_CBE
54.01
40%
-50
- C1 -
-
2GNJ
4.6
-
KAPCA_BOVIN
A:
[14-329]
-----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
I
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
160
Blastp_CBE
53.98
41%
-49
- C1 -
-
1XH9
9.9
-
KAPCA_BOVIN
A:
[13-329]
----------------------------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
E
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
L
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
490
Blastp_CBE
53.92
38%
-74
- C1 -
-
3IOP
9.4
-
PDPK1_HUMAN
A:
[34-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
------------N
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
Y
---
L
-----
I
F
Q
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
471
Blastp_CBE
53.86
37%
-24
- C1 -
-
5UVC
7.0
-
ARBK1_HUMAN
A:
[196-545]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
----
N
-----
D
F
S
V
H
R
I
I
G
R
G
-
G
F
G
E
V
Y
G
C
R
K
---
A
D
---
T
-
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
K
--
M
K
Q
G
E
T
-
L
A
L
N
E
R
I
M
L
-
S
---
L
-
V
---
S
-
T
GDC
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
--
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
--
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
-
E
H
G
H
V
R
I
S
D
L
G
L
A
-------
C
D
-
F
-
S
K
K
K
--
P
-
H
A
SV
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V--
A
-----
Y
D
-
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
-
H
S
P
F
-----
R
--
Q
HKT
K
----
D
K
---
H
---
E
-----
I
D
R
M
T
L
--
T
M
------
A
--
V
E
L
P
-----
D
S
---
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
--
R
L
G
C
------
L
G
-
R
G
A
-
Q
E
-
V
K
E
S
P
F
F
R
S
L
D
---
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
PRGEV
N
A
A
D
A
F
D
I
G
S
F
--
D
E
E
D
T
------------------------------------------
464
Blastp_CBE
53.73
37%
-65
- C1 -
-
3NUS
3.6
-
PDPK1_HUMAN
A:
[3-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
K
R
--
P
----
E
-----
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
------------N
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
Y
---
L
-----
I
F
Q
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
507
Blastp_CBE
53.70
38%
-77
- C1 -
-
3NAY
7.7
-
PDPK1_HUMAN
A:
[30-305]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
-----------
A
N
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
Y
---
L
-----
I
F
Q
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
432
Blastp_CBE
53.61
42%
-54
- C1 -
-
3ZO2
6.0
-
KAPCA_BOVIN
A:
[26-330]
----------------------------------------------------------------------------------------------------------------------------------------
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
278
Blastp_CBE
53.54
42%
-54
- C1 -
-
1SVE
8.0
-
KAPCA_BOVIN
A:
[25-329]
----------------------------------------------------------------------------------------------------------------------------------------
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
62
Blastp_CBE
53.53
48%
2
- C1 -
-
4L43
7.7
-
KS6B1_HUMAN
A:
[20-334]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
RN
A
K
D
-
T
A
-
H
T
K
A
E
R
N
I
L
-
E
---
E
-
V
---
K
-
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
--
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
--
E
S
-------------------
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
---
G
-----
H
N
-
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
--
G
---
E
----
N
R
---
K
---
K
-----
T
I
D
K
I
L
--
K
C
------
K
--
L
N
L
P
-----
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
------
G
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----
L
L
Q
S
E
E
D
V
S
Q
F
--
D
S
K
F
T
R
Q
T
P
V
D
S
P
----------------------------------
487
Blastp_CBE
53.52
38%
-76
- C1 -
-
3QCX
6.9
-
PDPK1_HUMAN
A:
[34-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
------------N
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
Y
---
L
-----
I
F
Q
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
498
Blastp_CBE
53.51
38%
-72
- C1 -
-
3H9O
7.5
-
PDPK1_HUMAN
A:
[33-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
------------N
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
Y
---
L
-----
I
F
Q
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
505
Blastp_CBE
53.49
38%
-73
* C1 *
-
3RWP
8.4
-
PDPK1_HUMAN
A:
[33-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
------------N
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
Y
---
L
-----
I
F
Q
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
441
Blastp_CBE
53.34
39%
-91
- C1 -
-
5LOH
8.1
-
GWL_HUMAN
B:
[33-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
--
I
----
E
-----
E
F
S
I
V
K
P
I
S
R
G
-
A
F
G
K
V
Y
L
G
Q
K
--------
G
-
G
----
K
L
Y
A
V
K
V
V
K
K
A
D
M
I
--
N
K
---------------
A
---
L
-
S
---
K
-
S
---
P
F
I
V
H
L
Y
Y
S
L
Q
S
A
N
N
V
Y
L
V
M
E
Y
L
I
G
G
D
V
K
S
L
L
H
I
--
Y
G
Y
F
D
E
E
M
A
V
K
Y
I
S
E
V
A
L
A
L
D
Y
L
H
R
-
H
G
--
I
I
H
R
D
L
K
P
D
N
M
L
I
S
-
N
E
G
H
I
K
L
T
D
F
G
L
-------------------------
G
T
P
D
Y
L
A
P
E
L
L
L
G
R
---
A
-----
H
G
-
P
A
V
D
W
W
A
L
G
V
C
L
F
E
F
L
T
G
-
I
P
P
F
-----
N
--
D
---
E
----
T
P
---
Q
---
Q
-----
V
F
Q
N
I
L
--
K
R
------
D
--
I
P
W
P
EGE--
E
K
---
L
S
D
N
A
Q
S
A
V
E
I
L
L
T
I
D
D
T
K
--
R
A
G
------------
M
-
K
E
-
L
K
R
H
P
L
F
S
D
V
D
---
W
E
N
L
Q
H
Q
T
M
--
P
F
I
P
-----
Q
P
----------------------------------------------------------
281
Blastp_CBE
53.35
42%
-53
- C1 -
-
1Q8T
3.8
-
KAPCA_BOVIN
A:
[25-329]
----------------------------------------------------------------------------------------------------------------------------------------
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
438
Blastp_CBE
53.34
41%
-60
- C1 -
-
4C34
9.0
-
KAPCA_BOVIN
A:
[26-330]
----------------------------------------------------------------------------------------------------------------------------------------
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
Y
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
-
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
484
Blastp_CBE
53.32
38%
-72
- C1 -
-
3QD3
9.1
-
PDPK1_HUMAN
A:
[34-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
------------N
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
Y
---
L
-----
I
F
Q
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
418
Blastp_CBE
53.28
41%
-53
- C1 -
-
2GNH
5.2
-
KAPCA_BOVIN
A:
[25-329]
----------------------------------------------------------------------------------------------------------------------------------------
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
I
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
223
Blastp_CBE
53.26
42%
-51
- C1 -
-
5BX6
3.7
-
KAPCA_HUMAN
A:
[26-330]
----------------------------------------------------------------------------------------------------------------------------------------
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
463
Blastp_CBE
53.23
37%
-66
- C1 -
-
3NUU
3.8
-
PDPK1_HUMAN
A:
[3-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
K
R
--
P
----
E
-----
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
------------N
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
Y
---
L
-----
I
F
Q
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
554
Fugue
53.19
40%
-5
- C1 -
-
1CDK
8.1
-
KAPCA_PIG
A:
[8-350]
---------------------------------------------------------------------------------------------
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
----
L
K
-----
K
W
E
N
P
A
Q
N
T
A
-------------------------
H
----
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
-G
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
G-----
N
H
F
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
AV-------
N
-
F
---
P
F
L
V
K
L
E
Y
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I--
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
---LD
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q-
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
V
--
K
----
G
--
R
TW
T
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
-KGY-------
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y-
P
P
F
-----
F
AD---------
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
KVRFPS-------------
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
D
G
V
-
N
D
-
I
K
N
H
K
W
F
A
---TTD
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
Y
E
E
E
E
I
R
V
S
I
-------------
N
E
K
C
G
K
E
---
F
S
E
F
--------
431
Blastp_CBE
53.17
42%
-51
- C1 -
-
1XH7
8.8
-
KAPCA_BOVIN
A:
[25-329]
----------------------------------------------------------------------------------------------------------------------------------------
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
488
Blastp_CBE
53.00
38%
-73
- C1 -
-
3QCS
6.2
-
PDPK1_HUMAN
A:
[34-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
------------N
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
Y
---
L
-----
I
F
Q
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
503
Blastp_CBE
53.06
38%
-74
- C1 -
-
3SC1
4.8
-
PDPK1_HUMAN
A:
[33-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
-----------
A
N
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
Y
---
L
-----
I
F
Q
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
222
Blastp_CBE
53.00
42%
-54
- C1 -
-
5BX7
3.7
-
KAPCA_HUMAN
A:
[26-330]
----------------------------------------------------------------------------------------------------------------------------------------
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
495
Blastp_CBE
52.98
38%
-70
- C1 -
-
1OKY
8.4
-
PDPK1_HUMAN
A:
[31-306]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
P
E
-
S
--------N
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
Y
---
L
-----
I
F
Q
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
184
Blastp_CBE
52.95
41%
-46
- C1 -
-
4AXA
7.1
-
KAPCA_BOVIN
A:
[15-330]
-----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
489
Blastp_CBE
52.93
38%
-72
- C1 -
-
3QCQ
6.2
-
PDPK1_HUMAN
A:
[34-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
------------N
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
Y
---
L
-----
I
F
Q
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
470
Blastp_CBE
52.91
38%
-73
- C1 -
-
3NUN
5.5
-
PDPK1_HUMAN
A:
[15-290]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
------------N
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
Y
---
L
-----
I
F
Q
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
575
HHSearch
52.87
46%
-7
- C1 -
-
4OTH
7.4
-
A:
[8-339]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
T
--
L
----
E
-----
D
F
K
F
L
A
V
L
G
R
G
-
H
F
G
K
V
L
L
S
E
F
---
R
P
---
S
-
G
----
E
L
F
A
I
K
A
L
K
K
G
D
I
V
--
A
R
D
E
V
E
-
S
L
M
C
E
K
R
I
L
-
A
---
A
-
V
TSA
G
-
H
---
P
F
L
V
N
L
F
G
C
F
Q
T
P
E
H
V
C
F
V
M
E
Y
S
A
G
G
D
L
M
L
H
I
H
S
---
D
V
F
S
E
P
R
A
I
F
Y
S
A
C
V
V
L
G
L
Q
F
L
H
E
-
H
K
--
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
-
T
E
G
Y
V
K
I
A
D
F
G
L
C
K
-----------------------------------------------
T
-
R
A
V
D
W
W
G
L
G
V
L
L
Y
E
M
L
V
G
-
E
S
P
F
-----
P
--
G
---
D
----
D
E
---
E
---
E
-----
V
F
D
S
I
V
--
N
D
------
E
--
V
R
Y
P
-----
R
F
---
L
S
A
E
A
I
G
I
M
R
R
L
L
R
R
N
P
E
R
--
R
L
G
S
------
S
E
-
R
D
A
-
E
D
-
V
K
K
Q
P
F
F
R
T
L
G
---
W
E
A
L
L
A
R
R
L
P
P
P
F
V
P
-----
T
L
S
G
R
T
D
V
S
N
F
--
D
E
E
F
T
G
E
A
P
T
L
S
P
P
R
D
A
R
-----
P
L
T
A
A
E
Q
A
A
---
F
L
D
F
D
F
V
A
G
---
409
Blastp_CBE
52.86
41%
-54
- C1 -
-
3AMA
6.8
-
KAPCA_HUMAN
A:
[26-330]
----------------------------------------------------------------------------------------------------------------------------------------
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
R
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
Q
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
-----
N
F
--
D
D
---------------------------------------------
475
Blastp_CBE
52.74
40%
-30
- C1 -
-
3NYO
4.6
-
GRK6_HUMAN
A:
[182-467]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
K
----
N
-----
T
F
R
Q
Y
R
V
L
G
K
G
-
G
F
G
E
V
C
A
C
Q
V
---
R
A
---
T
-
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
K
--
K
R
K
G
E
A
-
M
A
L
N
E
K
Q
I
L
-
E
---
K
-
V
---
N
-
S
---
R
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
MG
Q
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
--
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
D
H
G
H
I
R
I
S
D
L
G
L
A
V
--
H
--
V
P
E
-
G
-
Q
T
I
K
--
G
-
R
V
--
G
T
V
G
Y
M
A
P
E
V
V
K
N
E
---
R
-----
Y
T
-
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
-
Q
S
P
F
-----
Q
-------KKI-
K
R
---
E
---
E
-----
V
E
R
L
V
K
--
E
V
------
P
--
E
E
Y
S
-----
E
R
---
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
--
R
L
G
C
------
R
G
-
G
S
A
-
R
E
-
V
K
E
H
P
L
F
K
K
L
N
---
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
-----------------------------------------------------------------
424
Blastp_CBE
52.80
40%
-53
- C1 -
-
1XH4
8.9
-
KAPCA_BOVIN
A:
[14-329]
-----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
255
Blastp_CBE
52.79
40%
-53
- C1 -
-
6E9L
7.0
-
KAPCA_BOVIN
A:
[18-330]
--------------------------------------------------------------------------------------------------------------------------------
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
506
Blastp_CBE
52.78
38%
-78
- C1 -
-
3NAY
7.9
-
PDPK1_HUMAN
B:
[30-305]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
-----------
A
N
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
Y
---
L
-----
I
F
Q
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
436
Blastp_CBE
52.74
41%
-52
- C1 -
-
4C36
5.6
-
KAPCA_BOVIN
A:
[26-330]
----------------------------------------------------------------------------------------------------------------------------------------
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
Y
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
140
Blastp_CBE
52.72
43%
-56
- C1 -
-
3IDC
5.3
-
KAPCA_MOUSE
A:
[32-329]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
190
Blastp_CBE
52.71
40%
-49
- C1 -
-
6C0U
8.4
-
KAPCA_HUMAN
A:
[15-333]
---------------------------------------------------------------------------------------------------------------------
E
-----
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
457
Blastp_CBE
52.69
37%
-65
- C1 -
-
1UU9
3.2
-
PDPK1_HUMAN
A:
[4-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
K
R
--
P
----
E
-----
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
------------N
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
Y
---
L
-----
I
F
Q
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
245
Blastp_CBE
52.67
39%
-54
- C1 -
-
5VIB
7.8
-
KAPCA_BOVIN
A:
[19-351]
---------------------------------------------------------------------------------------------------------------------------------
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
---------
F
--
D
-
D
Y
E
E
E
E
I
R
-------------------------------------
578
HHSearch
52.57
45%
17
- C1 -
-
4L44
7.9
-
KS6B1_HUMAN
A:
[16-346]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
P
----
E
-----
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
---
V
T
GAN
T
-
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R-
N
A
K
D
T
A
-
H
T
K
A
E
R
N
I
L
-
E
---
E
-
V
---
K
-
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
--
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
--
E
S
-
I
H
-------
H
--
T
-
F
C
--
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
---
G
-----
H
N
-
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
--
G
---
E
----
N
R
---
K
---
K
-----
T
I
D
K
I
L
--
K
C
------
K
--
L
N
L
P
-----
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
------
G
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----
L
L
Q
S
E
E
D
V
S
Q
---
D
S
K
F
T
R
Q
T
-----------------
S
E
S
A
N
Q
V
---
F
L
G
F
A
Y
V
A
P
S
--
199
Blastp_CBE
52.65
44%
-62
- C1 -
-
5N7U
3.9
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
425
Blastp_CBE
52.57
40%
-53
- C1 -
-
1Q8W
4.8
-
KAPCA_BOVIN
A:
[14-329]
-----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
250
Blastp_CBE
52.61
40%
-52
- C1 -
-
1XH6
8.5
-
KAPCA_BOVIN
A:
[18-329]
---------------------------------------------------------------------------------------------------------------------------------
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
220
Blastp_CBE
52.61
43%
-47
- C1 -
-
2VO0
7.3
-
KAPCA_BOVIN
A:
[26-330]
----------------------------------------------------------------------------------------------------------------------------------------
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
276
Blastp_CBE
52.60
42%
-51
- C1 -
-
1VEB
7.9
-
KAPCA_BOVIN
A:
[25-329]
----------------------------------------------------------------------------------------------------------------------------------------
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
428
Blastp_CBE
52.59
40%
-49
- C1 -
-
3ZO1
5.7
-
KAPCA_BOVIN
A:
[10-330]
---------------------------------------------------------------------------------------------------------------
G
----
S
E
-----
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
282
Blastp_CBE
52.58
40%
-52
- C1 -
-
2GNL
4.8
-
KAPCA_BOVIN
A:
[11-329]
---------------------------------------------------------------------------------------------------------------------
E
-----
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
I
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
173
Blastp_CBE
52.57
40%
-53
- C1 -
-
4UJ1
6.0
-
KAPCA_HUMAN
A:
[15-330]
-----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
258
Blastp_CBE
52.50
40%
-50
- C1 -
-
3ZO4
7.2
-
KAPCA_BOVIN
A:
[15-330]
-----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
429
Blastp_CBE
52.44
40%
-52
- C1 -
-
2JDS
7.3
-
KAPCA_BOVIN
A:
[15-330]
-----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
341
Blastp_CBE
52.51
39%
-50
- C1 -
-
2GNF
4.3
-
KAPCA_BOVIN
A:
[10-329]
--------------------------------------------------------------------------------------------------------------------
S
E
-----
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
I
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
188
Blastp_CBE
52.50
41%
-52
- C1 -
-
2JDV
8.9
-
KAPCA_BOVIN
A:
[16-330]
------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
426
Blastp_CBE
52.40
40%
-56
- C1 -
-
5VHB
7.3
-
KAPCA_BOVIN
A:
[19-330]
---------------------------------------------------------------------------------------------------------------------------------
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------
G
D
T
S
N
F
--
D
D
---------------------------------------------
256
Blastp_CBE
52.44
40%
-53
- C1 -
-
6E99
7.7
-
KAPCA_BOVIN
A:
[19-330]
---------------------------------------------------------------------------------------------------------------------------------
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
251
Blastp_CBE
52.46
40%
-51
- C1 -
-
1XH5
9.1
-
KAPCA_BOVIN
A:
[14-329]
-----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
238
Blastp_CBE
52.44
40%
-52
- C1 -
-
3DND
3.3
-
KAPCA_BOVIN
A:
[15-329]
------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
D
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
225
Blastp_CBE
52.44
42%
-52
- C1 -
-
3VQH
6.8
-
KAPCA_HUMAN
A:
[26-330]
----------------------------------------------------------------------------------------------------------------------------------------
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
252
Blastp_CBE
52.43
40%
-50
- C1 -
-
1SVH
9.4
-
KAPCA_BOVIN
A:
[14-329]
-----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
476
Blastp_CBE
52.34
40%
-25
- C1 -
-
3NYN
5.4
-
GRK6_HUMAN
B:
[182-467]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
K
----
N
-----
T
F
R
Q
Y
R
V
L
G
K
G
-
G
F
G
E
V
C
A
C
Q
V
---
R
A
---
T
-
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
K
--
K
R
K
G
E
A
-
M
A
L
N
E
K
Q
I
L
-
E
---
K
-
V
---
N
-
S
---
R
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
MG
Q
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
--
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
D
H
G
H
I
R
I
S
D
L
G
L
A
V
--
H
--
V
P
E
-
G
-
Q
T
I
K
--
G
-
R
V
--
G
T
V
G
Y
M
A
P
E
V
V
K
N
E
---
R
-----
Y
T
-
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
-
Q
S
P
F
-----
Q
-------KKI-
K
R
---
E
---
E
-----
V
E
R
L
V
K
--
E
V
------
P
--
E
E
Y
S
-----
E
R
---
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
--
R
L
G
C
------
R
G
-
G
S
A
-
R
E
-
V
K
E
H
P
L
F
K
K
L
N
---
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
-----------------------------------------------------------------
482
Blastp_CBE
52.33
38%
-69
- C1 -
-
2XCH
7.3
-
PDPK1_HUMAN
A:
[31-306]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
-----------
A
N
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
Y
---
L
-----
I
F
Q
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
408
Blastp_CBE
52.27
41%
-54
- C1 -
-
3AMB
6.7
-
KAPCA_HUMAN
A:
[26-330]
----------------------------------------------------------------------------------------------------------------------------------------
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
R
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
Q
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
-----
N
F
--
D
D
---------------------------------------------
132
Blastp_CBE
52.41
43%
-62
- C1 -
-
4NTT
3.7
-
KAPCA_MOUSE
A:
[32-329]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
277
Blastp_CBE
52.40
42%
-52
- C1 -
-
1SVG
9.6
-
KAPCA_BOVIN
A:
[25-329]
----------------------------------------------------------------------------------------------------------------------------------------
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
543
Blastp_CBE
52.30
37%
-68
- C1 -
-
2XCK
8.6
-
PDPK1_HUMAN
A:
[31-306]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
T
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
-----------
A
N
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
Y
---
L
-----
I
F
Q
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
151
Blastp_CBE
52.35
43%
-56
- C1 -
-
6MM7
3.0
-
KAPCA_MOUSE
D:
[21-330]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
218
Blastp_CBE
52.34
44%
-60
- C1 -
-
5LCP
5.5
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
203
Blastp_CBE
52.33
44%
-60
- C1 -
-
5N1E
3.8
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
422
Blastp_CBE
52.26
40%
-51
- C1 -
-
3KKV
7.5
-
KAPCA_BOVIN
A:
[13-329]
----------------------------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
174
Blastp_CBE
52.33
40%
-51
- C1 -
-
3POO
7.1
-
KAPCA_HUMAN
A:
[15-330]
-----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
----
T
S
N
F
--
D
D
---------------------------------------------
247
Blastp_CBE
52.28
40%
-54
- C1 -
-
4IJ9
6.5
-
KAPCA_BOVIN
A:
[14-329]
-----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
491
Blastp_CBE
52.19
38%
-73
- C1 -
-
1UU8
3.1
-
PDPK1_HUMAN
A:
[31-306]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
-----------
A
N
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
Y
---
L
-----
I
F
Q
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
232
Blastp_CBE
52.28
40%
-53
- C1 -
-
3MVJ
4.5
-
KAPCA_HUMAN
E:
[36-350]
------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
235
Blastp_CBE
52.26
40%
-50
- C1 -
-
4YXS
5.1
-
KAPCA_BOVIN
A:
[14-329]
-----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
D
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
229
Blastp_CBE
52.26
40%
-53
- C1 -
-
1YDT
6.5
-
KAPCA_BOVIN
E:
[15-329]
------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
D
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
227
Blastp_CBE
52.27
42%
-53
- C1 -
-
3AGL
8.5
-
KAPCA_HUMAN
A:
[26-330]
----------------------------------------------------------------------------------------------------------------------------------------
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
177
Blastp_CBE
52.26
40%
-47
- C1 -
-
3OWP
5.6
-
KAPCA_HUMAN
A:
[16-330]
------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
189
Blastp_CBE
52.24
41%
-47
- C1 -
-
2JDT
6.4
-
KAPCA_BOVIN
A:
[16-330]
------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
206
Blastp_CBE
52.22
44%
-62
- C1 -
-
5M75
5.4
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
186
Blastp_CBE
52.22
41%
-44
- C1 -
-
2UW4
4.7
-
KAPCA_BOVIN
A:
[15-330]
-----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
-
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
262
Blastp_CBE
52.19
40%
-54
- C1 -
-
2C1A
6.4
-
KAPCA_BOVIN
A:
[15-330]
-----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
280
Blastp_CBE
52.17
42%
-51
- C1 -
-
1Q8U
5.6
-
KAPCA_BOVIN
A:
[25-329]
----------------------------------------------------------------------------------------------------------------------------------------
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
239
Blastp_CBE
52.15
40%
-48
- C1 -
-
4Z83
7.1
-
KAPCA_BOVIN
E:
[14-329]
-----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
466
Blastp_CBE
52.13
38%
-67
- C1 -
-
2R7B
6.8
-
PDPK1_HUMAN
A:
[34-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
VL-----------------
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
Y
---
L
-----
I
F
Q
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
170
Blastp_CBE
52.11
40%
-50
- C1 -
-
4UJA
7.0
-
KAPCA_HUMAN
A:
[14-330]
----------------------------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
433
Blastp_CBE
52.10
39%
-54
- C1 -
-
4C38
5.6
-
KAPCA_BOVIN
A:
[15-330]
-----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
Y
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
467
Blastp_CBE
51.91
38%
-65
- C1 -
-
3NAX
10.0
-
PDPK1_HUMAN
A:
[30-305]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
VL
S
P
-
E
S
K
-
Q
-
A
R
------------
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
Y
---
L
-----
I
F
Q
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
224
Blastp_CBE
52.08
42%
-50
- C1 -
-
4UJB
6.5
-
KAPCA_HUMAN
A:
[26-330]
----------------------------------------------------------------------------------------------------------------------------------------
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
290
Blastp_CBE
52.07
43%
-56
- C1 -
-
5JR7
5.2
-
KAPCA_MOUSE
A:
[32-329]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
236
Blastp_CBE
52.04
40%
-48
- C1 -
-
4YXR
3.8
-
KAPCA_BOVIN
A:
[15-329]
------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
D
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
230
Blastp_CBE
52.02
40%
-54
- C1 -
-
1YDS
4.4
-
KAPCA_BOVIN
E:
[15-329]
------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
D
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
143
Blastp_CBE
52.02
43%
-59
- C1 -
-
1REK
10.4
-
KAPCA_MOUSE
A:
[32-329]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
355
Blastp_CBE
52.00
43%
-63
- C1 -
-
6ERW
5.1
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
----
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
259
Blastp_CBE
51.97
40%
-55
- C1 -
-
3AG9
8.1
-
KAPCA_BOVIN
B:
[16-350]
------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
434
Blastp_CBE
51.91
39%
-50
- C1 -
-
4C37
6.0
-
KAPCA_BOVIN
A:
[14-330]
----------------------------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
Y
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
403
Blastp_CBE
51.98
43%
-57
- C1 -
-
5N1L
5.0
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
318
Blastp_CBE
51.94
43%
-55
- C1 -
-
4IAC
6.6
-
KAPCA_MOUSE
A:
[38-335]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
200
Blastp_CBE
51.97
44%
-62
- C1 -
-
5N7P
4.3
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
331
Blastp_CBE
51.95
40%
-48
- C1 -
-
2VO3
7.6
-
KAPCA_BOVIN
A:
[15-330]
-----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
338
Blastp_CBE
51.90
40%
-48
- C1 -
-
2UW0
8.2
-
KAPCA_BOVIN
A:
[15-330]
-----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
138
Blastp_CBE
51.94
43%
-56
- C1 -
-
3OW3
3.4
-
KAPCA_MOUSE
A:
[32-329]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
423
Blastp_CBE
51.86
40%
-47
- C1 -
-
3BWJ
9.6
-
KAPCA_BOVIN
A:
[10-329]
--------------------------------------------------------------------------------------------------------------------
S
E
-----
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
395
Blastp_CBE
51.93
43%
-58
- C1 -
-
5N3A
3.9
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
399
Blastp_CBE
51.86
43%
-58
- C1 -
-
5N33
3.5
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
397
Blastp_CBE
51.86
43%
-61
- C1 -
-
5N37
4.4
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
147
Blastp_CBE
51.92
43%
-56
- C1 -
-
1FMO
4.9
-
KAPCA_MOUSE
E:
[32-329]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
193
Blastp_CBE
51.91
44%
-61
- C1 -
-
6F14
4.3
-
KAPCA_CRIGR
A:
[41-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
-----
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
145
Blastp_CBE
51.90
43%
-56
- C1 -
-
1RE8
8.0
-
KAPCA_MOUSE
A:
[32-329]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
237
Blastp_CBE
51.88
40%
-51
- C1 -
-
3DNE
5.1
-
KAPCA_BOVIN
A:
[13-329]
----------------------------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
D
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
261
Blastp_CBE
51.86
40%
-52
- C1 -
-
2C1B
6.4
-
KAPCA_BOVIN
A:
[15-330]
-----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
201
Blastp_CBE
51.88
44%
-64
- C1 -
-
5N32
4.5
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
-
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
176
Blastp_CBE
51.87
40%
-52
- C1 -
-
3OXT
6.0
-
KAPCA_HUMAN
A:
[15-330]
-----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
172
Blastp_CBE
51.86
40%
-50
- C1 -
-
4UJ2
6.9
-
KAPCA_HUMAN
A:
[15-330]
-----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
330
Blastp_CBE
51.85
40%
-44
- C1 -
-
2VO6
7.7
-
KAPCA_BOVIN
A:
[14-330]
----------------------------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
468
Blastp_CBE
51.75
38%
-54
- C1 -
-
2BIY
5.7
-
PDPK1_HUMAN
A:
[31-306]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
VL
S
P
-
E
S
K
-
Q
-
A
R
A
N
--
A
-
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
Y
---
L
-----
I
F
Q
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
299
Blastp_CBE
51.83
43%
-59
- C1 -
-
4DG0
6.4
-
KAPCA_MOUSE
E:
[32-329]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
417
Blastp_CBE
51.75
41%
-51
- C1 -
-
2GNI
5.0
-
KAPCA_BOVIN
A:
[25-329]
----------------------------------------------------------------------------------------------------------------------------------------
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
I
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
396
Blastp_CBE
51.82
43%
-61
- C1 -
-
5N39
4.9
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
157
Blastp_CBE
51.80
41%
-51
- C1 -
-
3L9N
7.2
-
KAPCA_HUMAN
A:
[15-330]
-----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
---
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
141
Blastp_CBE
51.79
43%
-52
- C1 -
-
3IDB
6.5
-
KAPCA_MOUSE
A:
[32-329]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
474
Blastp_CBE
51.78
40%
-27
- C1 -
-
3NYO
4.7
-
GRK6_HUMAN
B:
[182-467]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
K
----
N
-----
T
F
R
Q
Y
R
V
L
G
K
G
-
G
F
G
E
V
C
A
C
Q
V
---
R
A
---
T
-
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
K
--
K
R
K
G
E
A
-
M
A
L
N
E
K
Q
I
L
-
E
---
K
-
V
---
N
-
S
---
R
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
MG
Q
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
--
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
D
H
G
H
I
R
I
S
D
L
G
L
A
V
--
H
--
V
P
E
-
G
-
Q
T
I
K
--
G
-
R
V
--
G
T
V
G
Y
M
A
P
E
V
V
K
N
E
---
R
-----
Y
T
-
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
-
Q
S
P
F
-----
Q
-------KKI-
K
R
---
E
---
E
-----
V
E
R
L
V
K
--
E
V
------
P
--
E
E
Y
S
-----
E
R
---
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
--
R
L
G
C
------
R
G
-
G
S
A
-
R
E
-
V
K
E
H
P
L
F
K
K
L
N
---
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
-----------------------------------------------------------------
407
Blastp_CBE
51.71
43%
-59
- C1 -
-
5NW8
4.8
-
KAPCA_CRIGR
A:
[41-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
333
Blastp_CBE
51.72
40%
-46
- C1 -
-
2VNW
5.3
-
KAPCA_BOVIN
A:
[15-330]
-----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
477
Blastp_CBE
51.58
40%
-20
- C1 -
-
3NYN
5.4
-
GRK6_HUMAN
A:
[182-467]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
K
----
N
-----
T
F
R
Q
Y
R
V
L
G
K
G
-
G
F
G
E
V
C
A
C
Q
V
---
R
A
---
T
-
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
K
--
K
R
K
G
E
A
-
M
A
L
N
E
K
Q
I
L
-
E
---
K
-
V
---
N
-
S
---
R
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
MG
Q
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
--
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
D
H
G
H
I
R
I
S
D
L
G
L
A
V
--
H
--
V
P
E
-
G
-
Q
T
I
K
--
G
-
R
V
--
G
T
V
G
Y
M
A
P
E
V
V
K
N
E
---
R
-----
Y
T
-
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
-
Q
S
P
F
-----
Q
-------KKI-
K
R
---
E
---
E
-----
V
E
R
L
V
K
--
E
V
------
P
--
E
E
Y
S
-----
E
R
---
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
--
R
L
G
C
------
R
G
-
G
S
A
-
R
E
-
V
K
E
H
P
L
F
K
K
L
N
---
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
-----------------------------------------------------------------
70
Blastp_CBE
51.76
47%
-25
- C1 -
-
5LI9
5.8
-
KPCI_HUMAN
A:
[5-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
Q
-----
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
---
K
K
---
T
-
D
----
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
--
D
D
E
D
I
D
-
W
V
Q
T
E
K
H
V
F
-
E
---
Q
A
S
---
N
-
H
---
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
--
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
--
E
G
-
L
R
P
-
G
-
D
T
-
T
--
S
-
F
C
--
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
---
D
-----
Y
G
-
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
D------------------E--
D
---
Y
-----
L
F
Q
V
I
L
--
E
K
------
Q
--
I
R
I
P
-----
R
S
---
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
------
H
P
-
Q
T
G
F
A
D
-
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
-----
N
I
S
G
E
F
G
L
D
N
F
--
D
S
Q
F
T
N
E
P
V
Q
L
------------------------------------
352
Blastp_CBE
51.75
43%
-61
- C1 -
-
6I2B
6.1
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
--
T
S
N
F
--
D
D
---------------------------------------------
376
Blastp_CBE
51.73
43%
-64
- C1 -
-
5NTJ
3.6
-
KAPCA_CRIGR
A:
[43-335]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
322
Blastp_CBE
51.72
43%
-54
- C1 -
-
4X6R
6.9
-
KAPCA_MOUSE
A:
[32-329]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
398
Blastp_CBE
51.65
43%
-58
- C1 -
-
5N36
2.7
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
53
Blastp_CBE
51.71
46%
14
- C1 -
-
4DC2
3.0
-
KPCI_MOUSE
A:
[49-363]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------LG
L
----
Q
-----
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
---
K
K
---
T
-
D
----
R
I
Y
A
M
R
V
V
K
K
E
L
V
N
------
I
D
-
W
V
Q
T
E
K
H
V
F
-
E
---
Q
A
S
---
N
-
H
---
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
--
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
--
E
G
-
L
R
P
-
G
-
D
T
T
S
--
T
-
F
C
--
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
---
D
-----
Y
G
-
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
DIVGS------------
N
T
---
E
---
D
Y----
L
F
Q
V
I
L
--
E
K
------
Q
--
I
R
I
P
-----
R
S
---
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
------
H
P
-
Q
T
G
F
A
D
-
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
-----
N
I
S
G
E
F
G
L
D
N
F
--
D
S
Q
F
T
N
E
P
V
Q
L
------------------------------------
153
Blastp_CBE
51.70
43%
-54
- C1 -
-
6MM6
3.3
-
KAPCA_MOUSE
E:
[21-338]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
370
Blastp_CBE
51.69
43%
-60
- C1 -
-
5OTG
4.9
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
144
Blastp_CBE
51.67
43%
-59
- C1 -
-
1REJ
6.2
-
KAPCA_MOUSE
A:
[32-329]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
439
Blastp_CBE
51.58
39%
-52
- C1 -
-
6FRX
6.6
-
KAPCA_HUMAN
A:
[13-330]
---------------------------------------------------------------------------------------------------------------------------
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
R
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
Q
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
-----
N
F
--
D
D
---------------------------------------------
499
Blastp_CBE
51.66
39%
-16
- C1 -
-
4TND
4.2
-
GRK5_HUMAN
A:
[182-467]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
K
----
N
-----
T
F
R
Q
Y
R
V
L
G
K
G
-
G
F
G
E
V
C
A
C
Q
V
---
R
A
---
T
-
G
----
K
M
Y
A
C
K
R
L
E
K
K
R
I
K
--
K
R
K
G
E
S
-
M
A
L
N
E
K
Q
I
L
-
E
---
K
-
V
---
N
-
S
---
Q
F
V
V
N
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
F
H
I
Y
N
MG
N
P
G
F
E
E
E
R
A
L
F
Y
A
A
E
I
L
C
G
L
E
D
L
H
H
-
E
N
--
T
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
D
Y
G
H
I
R
I
S
D
L
G
L
A
V
--
K
--
I
P
E
-
G
-
D
L
I
R
--
G
-
R
V
--
G
T
V
G
Y
M
A
P
E
V
L
N
N
Q
---
R
-----
Y
G
-
L
S
P
D
Y
W
G
L
G
C
L
I
Y
E
M
I
E
G
-
Q
S
P
F
-----
R
--
G
---
R
KEKV
K
R
---
E
---
E
-----
V
D
R
R
V
L
--
E
T
------
E
--
E
V
Y
S
-----
H
K
---
F
S
E
E
A
K
S
I
C
K
M
L
L
T
K
D
A
K
Q
--
R
L
G
C
------
Q
E
-
E
E
A
-
A
E
-
V
K
R
H
P
F
F
R
N
M
N
---
F
K
R
L
E
A
G
M
L
D
P
P
F
V
P
-----------------------------------------------------------------
165
Blastp_CBE
51.65
40%
-50
- C1 -
-
5UZK
8.5
-
KAPCA_HUMAN
A:
[15-330]
-----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
150
Blastp_CBE
51.65
43%
-57
- C1 -
-
6MM8
3.1
-
KAPCA_MOUSE
C:
[21-338]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
185
Blastp_CBE
51.64
41%
-46
- C1 -
-
2UW7
6.7
-
KAPCA_BOVIN
A:
[15-330]
-----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
297
Blastp_CBE
51.61
43%
-53
- C1 -
-
4DH1
6.3
-
KAPCA_MOUSE
A:
[32-329]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
334
Blastp_CBE
51.63
40%
-50
- C1 -
-
2UW8
3.8
-
KAPCA_BOVIN
A:
[15-330]
-----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
212
Blastp_CBE
51.61
44%
-57
- C1 -
-
5M0C
3.7
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
214
Blastp_CBE
51.60
44%
-64
- C1 -
-
5LCU
4.9
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
142
Blastp_CBE
51.61
43%
-52
- C1 -
-
3FJQ
8.6
-
KAPCA_MOUSE
E:
[32-329]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
226
Blastp_CBE
51.59
42%
-51
- C1 -
-
3AGL
8.9
-
KAPCA_HUMAN
B:
[26-330]
----------------------------------------------------------------------------------------------------------------------------------------
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
136
Blastp_CBE
51.60
43%
-54
- C1 -
-
4HPT
6.2
-
KAPCA_MOUSE
E:
[32-329]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
207
Blastp_CBE
51.59
44%
-61
- C1 -
-
5M71
5.1
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
205
Blastp_CBE
51.59
44%
-59
- C1 -
-
5MHI
3.5
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
94
Blastp_CBE
51.59
48%
-8
- C1 -
-
3WF7
7.9
-
KS6B1_HUMAN
A:
[21-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
RN
A
K
D
-
T
A
-
H
T
K
A
E
R
N
I
L
-
E
---
E
-
V
---
K
-
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
--
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
--
E
S
-
I
H
D
-----
V
T
--
H
-
F
C
--
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
---
G
-----
H
N
-
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
--
G
---
E
----
N
R
---
K
---
K
-----
T
I
D
K
I
L
--
K
C
------
K
--
L
N
L
P
-----
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
------
G
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----
L
L
Q
---------------------------------------------------------
364
Blastp_CBE
51.53
43%
-60
- C1 -
-
6EH3
4.6
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
217
Blastp_CBE
51.58
44%
-60
- C1 -
-
5LCQ
5.1
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
260
Blastp_CBE
51.57
40%
-53
- C1 -
-
2VO7
7.2
-
KAPCA_BOVIN
A:
[15-330]
-----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
339
Blastp_CBE
51.52
40%
-50
- C1 -
-
2UVZ
7.0
-
KAPCA_BOVIN
A:
[15-330]
-----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
63
Blastp_CBE
51.56
48%
5
- C1 -
-
4L45
8.3
-
KS6B1_HUMAN
A:
[20-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
RN
A
K
D
-
T
A
-
H
T
K
A
E
R
N
I
L
-
E
---
E
-
V
---
K
-
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
--
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
--
E
S
-------------------
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
---
G
-----
H
N
-
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
--
G
---
E
----
N
R
---
K
---
K
-----
T
I
D
K
I
L
--
K
C
------
K
--
L
N
L
P
-----
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
------
G
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----
L
L
Q
S
E
E
D
V
S
Q
F
--
D
S
K
F
T
R
Q
T
P
V
D
S
P
----------------------------------
465
Blastp_CBE
51.47
38%
-62
- C1 -
-
3ION
9.4
-
PDPK1_HUMAN
A:
[34-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
VL
S
-----------------
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
Y
---
L
-----
I
F
Q
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
254
Blastp_CBE
51.55
40%
-53
- C1 -
-
1Q24
7.4
-
KAPCA_BOVIN
A:
[14-329]
-----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
175
Blastp_CBE
51.54
40%
-50
- C1 -
-
3P0M
6.2
-
KAPCA_HUMAN
A:
[15-330]
-----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
314
Blastp_CBE
51.50
43%
-56
- C1 -
-
4IAK
6.1
-
KAPCA_MOUSE
A:
[38-335]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
148
Blastp_CBE
51.53
43%
-54
- C1 -
-
1ATP
7.7
-
KAPCA_MOUSE
E:
[32-329]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
125
Blastp_CBE
51.53
43%
-51
- C1 -
-
1JBP
5.3
-
KAPCA_MOUSE
E:
[32-329]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
E
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
209
Blastp_CBE
51.52
44%
-60
- C1 -
-
5M6V
5.8
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
394
Blastp_CBE
51.51
43%
-59
- C1 -
-
5N3B
2.7
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
182
Blastp_CBE
51.50
40%
-52
- C1 -
-
3AGM
7.1
-
KAPCA_HUMAN
A:
[13-330]
---------------------------------------------------------------------------------------------------------------------------
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
204
Blastp_CBE
51.49
44%
-60
- C1 -
-
5N1D
4.6
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
187
Blastp_CBE
51.48
41%
-49
- C1 -
-
2UVX
3.7
-
KAPCA_BOVIN
A:
[15-330]
-----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
360
Blastp_CBE
51.43
43%
-60
- C1 -
-
6EMB
5.6
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
327
Blastp_CBE
51.44
40%
-49
- C1 -
-
4WB5
8.4
-
KAPCA_HUMAN
A:
[13-329]
----------------------------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
335
Blastp_CBE
51.47
40%
-50
- C1 -
-
2UW6
5.5
-
KAPCA_BOVIN
A:
[15-330]
-----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
392
Blastp_CBE
51.46
43%
-57
- C1 -
-
5N3D
3.4
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
126
Blastp_CBE
51.44
43%
-57
- C1 -
-
2QUR
4.6
-
KAPCA_MOUSE
A:
[32-329]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
P
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
A
--
D
D
---------------------------------------------
368
Blastp_CBE
51.38
43%
-61
- C1 -
-
5OUC
4.4
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
257
Blastp_CBE
51.41
40%
-49
- C1 -
-
4IE9
4.4
-
KAPCA_BOVIN
A:
[15-330]
-----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
131
Blastp_CBE
51.43
43%
-59
- C1 -
-
4NTT
3.5
-
KAPCA_MOUSE
B:
[32-329]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
349
Blastp_CBE
51.38
43%
-60
- C1 -
-
6I2H
5.2
-
?
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
340
Blastp_CBE
51.37
40%
-47
- C1 -
-
2UVY
5.9
-
KAPCA_BOVIN
A:
[16-330]
------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
500
Blastp_CBE
51.32
39%
-13
- C1 -
-
4TNB
4.8
-
GRK5_HUMAN
A:
[182-467]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
K
----
N
-----
T
F
R
Q
Y
R
V
L
G
K
G
-
G
F
G
E
V
C
A
C
Q
V
---
R
A
---
T
-
G
----
K
M
Y
A
C
K
R
L
E
K
K
R
I
K
--
K
R
K
G
E
S
-
M
A
L
N
E
K
Q
I
L
-
E
---
K
-
V
---
N
-
S
---
Q
F
V
V
N
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
F
H
I
Y
N
MG
N
P
G
F
E
E
E
R
A
L
F
Y
A
A
E
I
L
C
G
L
E
D
L
H
H
-
E
N
--
T
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
D
Y
G
H
I
R
I
S
D
L
G
L
A
V
--
K
--
I
P
E
-
G
-
D
L
I
R
--
G
-
R
V
--
G
T
V
G
Y
M
A
P
E
V
L
N
N
Q
---
R
-----
Y
G
-
L
S
P
D
Y
W
G
L
G
C
L
I
Y
E
M
I
E
G
-
Q
S
P
F
-----
R
--
G
---
R
KEKV
K
R
---
E
---
E
-----
V
D
R
R
V
L
--
E
T
------
E
--
E
V
Y
S
-----
H
K
---
F
S
E
E
A
K
S
I
C
K
M
L
L
T
K
D
A
K
Q
--
R
L
G
C
------
Q
E
-
E
E
A
-
A
E
-
V
K
R
H
P
F
F
R
N
M
N
---
F
K
R
L
E
A
G
M
L
D
P
P
F
V
P
-----------------------------------------------------------------
354
Blastp_CBE
51.36
43%
-57
- C1 -
-
6ESA
6.3
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
242
Blastp_CBE
51.41
40%
-50
- C1 -
-
4Z84
5.6
-
KAPCA_BOVIN
A:
[15-330]
-----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
406
Blastp_CBE
51.34
43%
-62
- C1 -
-
5N1F
4.6
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
302
Blastp_CBE
51.37
43%
-53
- C1 -
-
1L3R
6.7
-
KAPCA_MOUSE
E:
[32-329]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
304
Blastp_CBE
51.38
43%
-53
- C1 -
-
4O21
5.5
-
KAPCA_MOUSE
A:
[24-321]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
353
Blastp_CBE
51.32
43%
-60
- C1 -
-
6I2A
5.6
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
348
Blastp_CBE
51.36
43%
-60
- C1 -
-
6EM7
7.6
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
393
Blastp_CBE
51.29
43%
-58
- C1 -
-
5N3C
2.9
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
309
Blastp_CBE
51.32
43%
-52
- C1 -
-
4IB3
6.6
-
KAPCA_MOUSE
A:
[38-335]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
391
Blastp_CBE
51.35
43%
-60
- C1 -
-
5N3E
3.1
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
427
Blastp_CBE
51.27
40%
-45
- C1 -
-
3ZO3
6.4
-
KAPCA_BOVIN
A:
[12-330]
---------------------------------------------------------------------------------------------------------------------
E
-----
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
316
Blastp_CBE
51.34
43%
-52
- C1 -
-
4IAF
6.3
-
KAPCA_MOUSE
A:
[38-335]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
337
Blastp_CBE
51.29
40%
-49
- C1 -
-
2UW3
4.5
-
KAPCA_BOVIN
A:
[15-330]
-----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
137
Blastp_CBE
51.33
43%
-55
- C1 -
-
4DIN
5.7
-
KAPCA_MOUSE
A:
[32-329]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
288
Blastp_CBE
51.32
43%
-54
- C1 -
-
3PVB
5.8
-
KAPCA_MOUSE
A:
[27-324]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
365
Blastp_CBE
51.31
43%
-65
- C1 -
-
6EH2
5.0
-
KAPCA_CRIGR
A:
[43-335]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
----
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
--
D
T
S
N
F
--
D
D
---------------------------------------------
336
Blastp_CBE
51.30
40%
-49
- C1 -
-
2UW5
6.6
-
KAPCA_BOVIN
A:
[16-330]
------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
231
Blastp_CBE
51.29
40%
-52
- C1 -
-
1YDR
4.6
-
KAPCA_BOVIN
E:
[15-329]
------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
D
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
357
Blastp_CBE
51.27
43%
-60
- C1 -
-
6ERT
5.5
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
317
Blastp_CBE
51.26
43%
-52
- C1 -
-
4IAD
6.3
-
KAPCA_MOUSE
A:
[38-335]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
400
Blastp_CBE
51.23
43%
-65
- C1 -
-
5N1O
4.2
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
-
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
386
Blastp_CBE
51.16
43%
-59
- C1 -
-
5N3J
3.9
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
402
Blastp_CBE
51.21
43%
-61
- C1 -
-
5N1M
3.5
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
321
Blastp_CBE
51.17
43%
-52
- C1 -
-
3X2U
5.7
-
KAPCA_MOUSE
A:
[39-336]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
294
Blastp_CBE
51.18
43%
-54
- C1 -
-
4DH7
7.7
-
KAPCA_MOUSE
A:
[32-329]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
305
Blastp_CBE
51.17
43%
-51
- C1 -
-
6E21
6.5
-
KAPCA_MOUSE
A:
[38-335]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
315
Blastp_CBE
51.16
43%
-51
- C1 -
-
4IAI
6.9
-
KAPCA_MOUSE
A:
[38-335]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
351
Blastp_CBE
51.10
43%
-58
- C1 -
-
6I2C
5.2
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
---
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
390
Blastp_CBE
51.07
43%
-61
- C1 -
-
5N3F
3.5
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
--
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
-
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
373
Blastp_CBE
51.07
43%
-60
- C1 -
-
5OK3
5.7
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
430
Blastp_CBE
51.03
41%
-39
- C1 -
-
4WB6
7.9
-
KAPCA_HUMAN
A:
[25-342]
----------------------------------------------------------------------------------------------------------------------------------------
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
R
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
-
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
-------------------------------
310
Blastp_CBE
51.07
43%
-53
- C1 -
-
4IB1
6.6
-
KAPCA_MOUSE
A:
[38-335]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
293
Blastp_CBE
51.10
43%
-52
- C1 -
-
4DH8
8.0
-
KAPCA_MOUSE
A:
[32-329]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
405
Blastp_CBE
51.03
43%
-58
- C1 -
-
5N1G
2.9
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
350
Blastp_CBE
51.04
43%
-59
- C1 -
-
6I2D
6.2
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
234
Blastp_CBE
51.08
40%
-46
- C1 -
-
3MVJ
4.7
-
KAPCA_HUMAN
A:
[36-350]
------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
292
Blastp_CBE
51.07
43%
-56
- C1 -
-
4HPU
7.3
-
KAPCA_MOUSE
E:
[32-329]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
179
Blastp_CBE
51.06
40%
-51
- C1 -
-
3OOG
3.8
-
KAPCA_HUMAN
A:
[17-330]
-------------------------------------------------------------------------------------------------------------------------------
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
155
Blastp_CBE
51.05
43%
-52
- C1 -
-
6MM5
2.8
-
KAPCA_MOUSE
E:
[21-318]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
244
Blastp_CBE
51.03
43%
-51
- C1 -
-
3FHI
8.3
-
KAPCA_MOUSE
A:
[32-329]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
A
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
374
Blastp_CBE
50.99
43%
-56
- C1 -
-
5O5M
6.3
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
--
T
S
N
F
--
D
D
---------------------------------------------
213
Blastp_CBE
51.04
44%
-60
- C1 -
-
5M0B
4.5
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
181
Blastp_CBE
51.03
40%
-49
- C1 -
-
3L9L
7.5
-
KAPCA_HUMAN
A:
[12-330]
---------------------------------------------------------------------------------------------------------------------
E
-----
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
156
Blastp_CBE
50.99
43%
-53
- C1 -
-
2GU8
6.2
-
KAPCA_HUMAN
A:
[19-316]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
E
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
307
Blastp_CBE
50.98
43%
-53
- C1 -
-
4XW5
6.4
-
KAPCA_MOUSE
A:
[38-335]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
358
Blastp_CBE
50.97
43%
-58
- C1 -
-
6ERS
5.2
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
---
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
324
Blastp_CBE
50.93
43%
-53
- C1 -
-
4DFX
6.6
-
KAPCA_MOUSE
E:
[32-329]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
134
Blastp_CBE
50.95
43%
-58
- C1 -
-
1BX6
6.0
-
KAPCA_MOUSE
A:
[32-329]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
306
Blastp_CBE
50.94
43%
-55
- C1 -
-
4XW6
6.0
-
KAPCA_MOUSE
A:
[38-335]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
159
Blastp_CBE
50.93
41%
-46
- C1 -
-
3L9M
7.5
-
KAPCA_HUMAN
A:
[12-330]
---------------------------------------------------------------------------------------------------------------------
E
-----
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
178
Blastp_CBE
50.91
40%
-48
- C1 -
-
3OVV
6.4
-
KAPCA_HUMAN
A:
[15-330]
-----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
362
Blastp_CBE
50.90
43%
-61
- C1 -
-
6EM6
5.7
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
361
Blastp_CBE
50.89
43%
-58
- C1 -
-
6EMA
5.4
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
249
Blastp_CBE
50.88
40%
-50
- C1 -
-
1XH8
10.0
-
KAPCA_BOVIN
A:
[12-329]
---------------------------------------------------------------------------------------------------------------------------
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
384
Blastp_CBE
50.81
43%
-58
- C1 -
-
5N3L
3.8
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
296
Blastp_CBE
50.86
43%
-52
- C1 -
-
4DH3
7.4
-
KAPCA_MOUSE
A:
[32-329]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
371
Blastp_CBE
50.84
43%
-58
- C1 -
-
5OT3
6.1
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
319
Blastp_CBE
50.80
43%
-51
- C1 -
-
3X2W
6.5
-
KAPCA_MOUSE
A:
[39-336]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
111
Blastp_CBE
50.81
48%
-5
- C1 -
-
4L3L
8.1
-
KS6B1_HUMAN
A:
[20-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
RN
A
K
D
-
T
A
-
H
T
K
A
E
R
N
I
L
-
E
---
E
-
V
---
K
-
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
--
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
--
E
S
-
I
H
D
-
G
-
T
V
T
H
--
T
-
F
C
--
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
---
G
-----
H
N
-
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
--
G
---
E
----
N
R
---
K
---
K
-----
T
I
D
K
I
L
--
K
C
------
K
--
L
N
L
P
-----
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
------
G
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----
L
L
Q
S
--------------------------------------------------------
263
Blastp_CBE
50.80
42%
-46
- C1 -
-
4WB6
8.3
-
KAPCA_HUMAN
B:
[25-329]
----------------------------------------------------------------------------------------------------------------------------------------
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
R
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
320
Blastp_CBE
50.75
43%
-51
- C1 -
-
3X2V
6.8
-
KAPCA_MOUSE
A:
[39-336]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
122
Blastp_CBE
50.78
40%
-40
- C1 -
-
1CDK
8.0
-
KAPCA_PIG
B:
[8-342]
--------------------------------------------------------------------------------------------------------------
K
G
----
S
E
-----
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
F
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
Y
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
D
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
-
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
-------------------------------
284
Blastp_CBE
50.75
40%
-50
- C1 -
-
3NX8
2.6
-
KAPCA_HUMAN
A:
[16-330]
------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
-
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
359
Blastp_CBE
50.77
43%
-58
- C1 -
-
6EMD
6.0
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
300
Blastp_CBE
50.74
43%
-53
- C1 -
-
2QCS
8.3
-
KAPCA_MOUSE
A:
[32-329]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
61
Blastp_CBE
50.75
48%
9
- C1 -
-
4L44
7.9
-
KS6B1_HUMAN
A:
[20-346]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
RN
A
K
D
-
T
A
-
H
T
K
A
E
R
N
I
L
-
E
---
E
-
V
---
K
-
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
--
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
--
E
S
-
I
H
-------
H
--
T
-
F
C
--
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
---
G
-----
H
N
-
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
--
G
---
E
----
N
R
---
K
---
K
-----
T
I
D
K
I
L
--
K
C
------
K
--
L
N
L
P
-----
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
------
G
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----
L
L
Q
S
E
E
D
V
S
Q
---
D
S
K
F
T
R
Q
T
P
V
D
S
P
----------------------------------
60
Blastp_CBE
50.74
45%
-6
- C1 -
-
4L42
7.7
-
KS6B1_HUMAN
A:
[20-344]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
RN
A
K
D
-
T
A
-
H
T
K
A
E
R
N
I
L
-
E
---
E
-
V
---
K
-
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
--
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
--
E
S
-
I
H
D
-
G
-
T
V
T
H
--
T
-
F
C
--
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
---
G
-----
H
N
-
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
--
G
---
E
----
N
R
---
K
---
K
-----
T
I
D
K
I
L
--
K
C
------
K
--
L
N
L
P
-----
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
------
G
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
-------------------------------------------------
E
M
---
F
R
D
F
E
Y
I
A
----
381
Blastp_CBE
50.70
43%
-59
- C1 -
-
5N3P
3.9
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
313
Blastp_CBE
50.69
43%
-54
- C1 -
-
4IAY
6.2
-
KAPCA_MOUSE
A:
[38-335]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
221
Blastp_CBE
50.68
43%
-52
- C1 -
-
3QAM
7.7
-
KAPCA_MOUSE
E:
[32-329]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
A
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
241
Blastp_CBE
50.66
43%
-55
- C1 -
-
3QAL
8.3
-
KAPCA_MOUSE
E:
[32-329]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
A
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
385
Blastp_CBE
50.64
43%
-59
- C1 -
-
5N3K
3.5
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
216
Blastp_CBE
50.62
44%
-57
- C1 -
-
5LCR
4.9
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
372
Blastp_CBE
50.61
43%
-56
- C1 -
-
5OL3
6.1
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
208
Blastp_CBE
50.58
44%
-58
- C1 -
-
5M6Y
5.3
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
389
Blastp_CBE
50.51
43%
-59
- C1 -
-
5N3G
4.1
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
311
Blastp_CBE
50.52
43%
-50
- C1 -
-
4IB0
6.7
-
KAPCA_MOUSE
A:
[38-335]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
127
Blastp_CBE
50.55
42%
-45
- C1 -
-
3O7L
5.5
-
KAPCA_MOUSE
B:
[32-346]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
----
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
I
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
I
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
-
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
-------------------------------
383
Blastp_CBE
50.49
43%
-59
- C1 -
-
5N3M
3.4
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
243
Blastp_CBE
50.52
43%
-53
- C1 -
-
1RDQ
7.3
-
KAPCA_MOUSE
E:
[32-329]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
A
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
180
Blastp_CBE
50.52
40%
-51
- C1 -
-
3L9L
7.4
-
KAPCA_HUMAN
B:
[13-330]
---------------------------------------------------------------------------------------------------------------------------
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
291
Blastp_CBE
50.51
43%
-53
- C1 -
-
4WBB
5.6
-
KAPCA_MOUSE
B:
[32-329]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
99
Blastp_CBE
50.50
47%
-24
- C1 -
-
5LI1
6.9
-
KPCI_HUMAN
A:
[9-321]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
Q
-----
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
---
K
K
---
T
-
D
----
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
--
D
D
E
D
I
D
-
W
V
Q
T
E
K
H
V
F
-
E
---
Q
A
S
---
N
-
H
---
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
--
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
--
E
G
-
L
R
P
-
G
-
D
T
-
T
--
S
-
F
C
--
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
---
D
-----
Y
G
-
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
DIV----------------E--
D
---
Y
-----
L
F
Q
V
I
L
--
E
K
------
Q
--
I
R
I
P
-----
R
----
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
------
H
P
-
Q
T
G
F
A
D
-
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
-----
N
I
S
G
E
F
G
L
D
N
F
--
D
S
Q
F
T
N
E
P
V
Q
L
------------------------------------
312
Blastp_CBE
50.49
43%
-54
- C1 -
-
4IAZ
6.2
-
KAPCA_MOUSE
A:
[38-335]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
295
Blastp_CBE
50.48
43%
-50
- C1 -
-
4DH5
6.0
-
KAPCA_MOUSE
A:
[32-329]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
135
Blastp_CBE
50.47
43%
-56
- C1 -
-
1BKX
4.4
-
KAPCA_MOUSE
A:
[32-329]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
380
Blastp_CBE
50.43
43%
-60
- C1 -
-
5N3Q
3.5
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
285
Blastp_CBE
50.42
42%
-45
- C1 -
-
4DG3
6.7
-
KAPCA_MOUSE
E:
[53-363]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
-
D
Y
E
E
E
E
I
A
V
S
I
N
E
K
-------------------------------
210
Blastp_CBE
50.41
44%
-60
- C1 -
-
5M0U
Error
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
-----
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
97
Blastp_CBE
50.40
48%
-9
- C1 -
-
3WE4
5.2
-
KS6B1_HUMAN
A:
[21-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
RN
A
K
D
-
T
A
-
H
T
K
A
E
R
N
I
L
-
E
---
E
-
V
---
K
-
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
--
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
--
E
S
-
I
H
D
-----
V
T
--
H
-
F
C
--
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
---
G
-----
H
N
-
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
--
G
---
E
----
N
R
---
K
---
K
-----
T
I
D
K
I
L
--
K
C
------
K
--
L
N
L
P
-----
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
------
G
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----
L
L
Q
---------------------------------------------------------
215
Blastp_CBE
50.38
44%
-59
- C1 -
-
5LCT
4.9
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
366
Blastp_CBE
50.34
43%
-55
- C1 -
-
6EGW
6.1
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
-------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
-
D
T
S
N
F
--
D
D
---------------------------------------------
382
Blastp_CBE
50.28
43%
-58
- C1 -
-
5N3O
4.0
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
112
Blastp_CBE
50.32
48%
-3
- C1 -
-
4L3J
8.0
-
KS6B1_HUMAN
A:
[20-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
RN
A
K
D
-
T
A
-
H
T
K
A
E
R
N
I
L
-
E
---
E
-
V
---
K
-
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
--
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
--
E
S
-
I
H
D
-
G
-
T
V
T
H
--
T
-
F
C
--
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
---
G
-----
H
N
-
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
--
G
---
E
----
N
R
---
K
---
K
-----
T
I
D
K
I
L
--
K
C
------
K
--
L
N
L
P
-----
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
------
G
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----
L
L
Q
S
--------------------------------------------------------
404
Blastp_CBE
50.29
43%
-60
- C1 -
-
5N1H
3.8
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
109
Blastp_CBE
50.28
47%
-4
- C1 -
-
4OTH
7.4
-
A:
[10-316]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
L
----
E
-----
D
F
K
F
L
A
V
L
G
R
G
-
H
F
G
K
V
L
L
S
E
F
---
R
P
---
S
-
G
----
E
L
F
A
I
K
A
L
K
K
G
D
I
V
--
A
R
D
E
V
E
-
S
L
M
C
E
K
R
I
L
-
A
AVT
S
-
A
---
G
-
H
---
P
F
L
V
N
L
F
G
C
F
Q
T
P
E
H
V
C
F
V
M
E
Y
S
A
G
G
D
L
M
L
H
I
H
S
--
D
-
V
F
S
E
P
R
A
I
F
Y
S
A
C
V
V
L
G
L
Q
F
L
H
E
-
H
K
--
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
-
T
E
G
Y
V
K
I
A
D
F
G
L
C
K
-----------------------------------------------
T
-
R
A
V
D
W
W
G
L
G
V
L
L
Y
E
M
L
V
G
-
E
S
P
F
-----
P
--
G
---
D
----
D
E
---
E
---
E
-----
V
F
D
S
I
V
--
N
D
------
E
--
V
R
Y
P
-----
R
F
---
L
S
A
E
A
I
G
I
M
R
R
L
L
R
R
N
P
E
R
--
R
L
G
S
------
S
E
-
R
D
A
-
E
D
-
V
K
K
Q
P
F
F
R
T
L
G
---
W
E
A
L
L
A
R
R
L
P
P
P
F
V
P
-----
T
L
S
G
R
T
D
V
S
N
F
--
D
E
E
F
T
G
E
A
P
T
L
P
P
----------------------------------
452
Blastp_CBE
50.24
39%
-22
- C1 -
-
6BDL
3.1
-
B:
[33-326]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
S
-----
D
F
N
I
I
D
T
L
G
V
G
-
G
F
G
R
V
E
L
V
Q
L
---
K
S
---
E
E
S
----
K
T
F
A
M
K
I
L
K
K
R
H
I
V
--
D
T
R
Q
Q
E
-
H
I
R
S
E
K
Q
I
M
-
Q
---
G
-
A
---
H
-
S
---
D
F
I
V
R
L
Y
R
T
F
K
D
S
K
Y
L
Y
M
L
M
E
A
C
L
G
G
E
L
W
T
I
L
R
D
--
R
G
S
F
E
D
S
T
T
R
F
Y
T
A
C
V
V
E
A
F
A
Y
L
H
S
-
K
G
--
I
I
Y
R
D
L
K
P
E
N
L
I
L
D
-
H
R
G
Y
A
K
L
V
D
F
G
F
A
K
--
K
---
I
G
-
F
-
G
K
K
T
--
W
-
F
C
--
G
T
P
E
Y
V
A
P
E
I
I
L
N
K
---
G
-----
H
D
-
I
S
A
D
Y
W
S
L
G
I
L
M
Y
E
L
L
T
G
-
S
P
P
F
-----
S
--
G
---
P
----
D
P
---
M
---
K
-----
T
Y
N
I
I
L
RG
I
D
------
M
--
I
E
F
P
-----
K
K
---
I
A
K
N
A
A
N
L
I
K
K
L
C
R
D
N
P
S
E
--
R
L
G
N
------
L
K
-
N
G
V
-
K
D
-
I
Q
K
H
K
W
F
E
G
F
N
---
W
E
G
L
R
K
G
T
L
T
P
P
I
I
P
-----
S
V
A
S
P
T
D
T
S
N
F
--
D
----------------------------------------------
123
Blastp_CBE
50.22
40%
-40
- C1 -
-
1CDK
8.0
-
KAPCA_PIG
A:
[8-342]
--------------------------------------------------------------------------------------------------------------
K
G
----
S
E
-----
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
F
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
Y
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
D
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
-
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
-------------------------------
363
Blastp_CBE
50.21
43%
-60
- C1 -
-
6EM2
4.8
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
211
Blastp_CBE
50.20
44%
-54
- C1 -
-
5M0L
4.1
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
202
Blastp_CBE
50.16
44%
-54
- C1 -
-
5N1K
3.4
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
----
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
388
Blastp_CBE
50.15
43%
-58
- C1 -
-
5N3H
3.5
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
110
Blastp_CBE
50.10
47%
-21
- C1 -
-
4OTG
8.7
-
A:
[10-316]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
L
----
E
-----
D
F
K
F
L
A
V
L
G
R
G
-
H
F
G
K
V
L
L
S
E
F
---
R
P
---
S
-
G
----
E
L
F
A
I
K
A
L
K
K
G
D
I
V
--
A
R
D
E
V
E
-
S
L
M
C
E
K
R
I
L
-
A
AVT
S
-
A
---
G
-
H
---
P
F
L
V
N
L
F
G
C
F
Q
T
P
E
H
V
C
F
V
M
E
Y
S
A
G
G
D
L
M
L
H
I
H
S
--
D
-
V
F
S
E
P
R
A
I
F
Y
S
A
C
V
V
L
G
L
Q
F
L
H
E
-
H
K
--
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
-
T
E
G
Y
V
K
I
A
D
F
G
L
C
K
--
E
G
-
M
-
G
-
Y
-
G
D
R
T
--
S
-
F
C
--
G
T
P
E
F
L
A
P
E
V
L
T
D
T
---
S
-----
Y
T
-
R
A
V
D
W
W
G
L
G
V
L
L
Y
E
M
L
V
G
-
E
S
P
F
-----
P
--
G
---
D
----
D
E
---
E
---
E
-----
V
F
D
S
I
V
--
N
D
------
E
--
V
R
Y
P
-----
R
F
---
L
S
A
E
A
I
G
I
M
R
R
L
L
R
R
N
P
E
R
--
R
L
G
S
------
S
E
-
R
D
A
-
E
D
-
V
K
K
Q
P
F
F
R
T
L
G
---
W
E
A
L
L
A
R
R
L
P
P
P
F
V
P
-----
T
L
S
--------------
T
G
E
A
P
T
L
P
P
----------------------------------
77
Blastp_CBE
50.10
47%
-22
- C1 -
-
3A8W
6.1
-
KPCI_HUMAN
B:
[8-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
Q
-----
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
---
K
K
---
T
-
D
----
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
--
D
D
E
D
I
D
-
W
V
Q
T
E
K
H
V
F
-
E
---
Q
A
S
---
N
-
H
---
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
--
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
--
E
G
-----
G
-
D
T
-
T
--
S
-
F
C
--
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
---
D
-----
Y
G
-
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
DI--------------------
E
---
D
Y----
L
F
Q
V
I
L
--
E
K
------
Q
--
I
R
I
P
-----
R
S
---
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
------
H
P
-
Q
T
G
F
A
D
-
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
-----
N
I
S
G
E
F
G
L
D
N
F
--
D
S
Q
F
T
N
E
P
V
Q
L
------------------------------------
119
Blastp_CBE
50.09
46%
21
- C1 -
-
1VZO
3.6
-
KS6A5_HUMAN
A:
[31-352]
--------------------------------------------------------------------------------------------------------------------------------------
Q
L
L
T
V
K
H
E
L
R
T
A
N
L
T
G
----
H
--
A
E
K
V
G-
I
----
E
-----
N
F
E
L
L
K
V
L
G
T
G
-
A
Y
G
K
V
F
L
V
R
K
---
I
S
GHD
T
-
G
----
K
L
Y
A
M
K
V
L
K
K
A
T
I
V
--
Q
K
A
K
T
T
E
H
T
R
T
E
R
Q
V
L
-
E
---
H
-
I
---
R
-
Q
S--
P
F
L
V
T
L
H
Y
A
F
Q
T
E
T
K
L
H
L
I
L
D
Y
I
N
G
G
E
L
F
T
H
L
S
Q
--
R
E
R
F
T
E
H
E
V
Q
I
Y
V
G
E
I
V
L
A
L
E
H
L
H
K
-
L
G
--
I
I
Y
R
D
I
K
L
E
N
I
L
L
D
-
S
N
G
H
V
V
L
T
D
F
G
L
S
K
--
E
F
-
V
A
D
-
E
-
T
E
R
A
Y-
D
-
F
C
--
G
T
I
E
Y
M
A
P
D
I
V
R
G
G
---
D
-------D
K
A
V
D
W
W
S
L
G
V
L
M
Y
E
L
L
T
G
-
A
S
P
F
--------
T
---
V
----
D
G
---
E
---
K
NSQAE
I
S
R
R
I
L
--
K
S
------
E
--
P
P
Y
P
-----
Q
E
---
M
S
A
L
A
K
D
L
I
Q
R
L
L
M
K
D
P
K
K
--
R
L
G
C
------
G
P
-
R
D
A
-
D
E
-
I
K
E
H
L
F
F
Q
K
I
N
---
W
D
D
L
A
A
K
K
V
P
A
P
F
K
P
-----
V
I
R
D
E
L
D
V
----------------------------------------------------
105
Blastp_CBE
50.00
44%
24
- C1 -
-
4NW6
8.2
-
KS6A3_HUMAN
A:
[15-322]
-------------------------------------------------------------------------------------------------------------------------------------------------
A
I
T
H
H
VKEG
H
--
E
K
A
D
--
P
----
S
-----
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
----
K
I
---
S
-
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
--
V
R
D
R
V
--
R
T
K
M
E
R
D
I
L
-
V
---
E
-
V
---
N
-
H
---
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
--
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
--
E
S
-
I
D
H
-
E
-
K
K
A
Y
--
S
-
F
C
--
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
-----
H
T
-
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
--
G
---
K
----
D
R
---
K
---
E
-----
T
M
T
M
I
L
--
K
A
------
K
--
L
G
M
P
-----
Q
F
---
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
A
------
G
P
-
D
G
V
-
E
E
-
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
------------
T
F
Y
F
--
D
----------------------------------------------
378
Blastp_CBE
49.98
43%
-59
- C1 -
-
5N3S
3.3
-
KAPCA_CRIGR
A:
[43-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
D
-----
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
308
Blastp_CBE
49.96
43%
-49
- C1 -
-
4XW4
6.0
-
KAPCA_MOUSE
A:
[38-335]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
108
Blastp_CBE
49.95
47%
-4
- C1 -
-
4OTI
6.1
-
A:
[10-316]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
L
----
E
-----
D
F
K
F
L
A
V
L
G
R
G
-
H
F
G
K
V
L
L
S
E
F
---
R
P
---
S
-
G
----
E
L
F
A
I
K
A
L
K
K
G
D
I
V
--
A
R
D
E
V
E
-
S
L
M
C
E
K
R
I
L
-
A
AVT
S
-
A
---
G
-
H
---
P
F
L
V
N
L
F
G
C
F
Q
T
P
E
H
V
C
F
V
M
E
Y
S
A
G
G
D
L
M
L
H
I
H
S
--
D
-
V
F
S
E
P
R
A
I
F
Y
S
A
C
V
V
L
G
L
Q
F
L
H
E
-
H
K
--
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
-
T
E
G
Y
V
K
I
A
D
F
G
L
-------------------------------------------------
T
-
R
A
V
D
W
W
G
L
G
V
L
L
Y
E
M
L
V
G
-
E
S
P
F
-----
P
--
G
---
D
----
D
E
---
E
---
E
-----
V
F
D
S
I
V
--
N
D
------
E
--
V
R
Y
P
-----
R
F
---
L
S
A
E
A
I
G
I
M
R
R
L
L
R
R
N
P
E
R
--
R
L
G
S
------
S
E
-
R
D
A
-
E
D
-
V
K
K
Q
P
F
F
R
T
L
G
---
W
E
A
L
L
A
R
R
L
P
P
P
F
V
P
-----
T
L
S
G
R
T
D
V
S
N
F
--
D
E
E
F
T
G
E
A
P
T
L
P
P
----------------------------------
106
Blastp_CBE
49.93
44%
28
- C1 -
-
4NW5
8.0
-
KS6A3_HUMAN
A:
[15-322]
-------------------------------------------------------------------------------------------------------------------------------------------------
A
I
T
H
H
VKEG
H
--
E
K
A
D
--
P
----
S
-----
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
----
K
I
---
S
-
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
--
V
R
D
R
V
--
R
T
K
M
E
R
D
I
L
-
V
---
E
-
V
---
N
-
H
---
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
--
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
--
E
S
-
I
D
H
-
E
-
K
K
A
Y
--
S
-
F
C
--
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
-----
H
T
-
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
--
G
---
K
----
D
R
---
K
---
E
-----
T
M
T
M
I
L
--
K
A
------
K
--
L
G
M
P
-----
Q
F
---
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
A
------
G
P
-
D
G
V
-
E
E
-
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
------------
T
F
Y
F
--
D
----------------------------------------------
535
Blastp_CBE
49.92
38%
-72
- C1 -
-
4AW1
7.7
-
PDPK1_HUMAN
A:
[33-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
P
E
-
S
--------N
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
G
---
L
-----
I
F
A
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
66
Blastp_CBE
49.91
47%
-20
- C1 -
-
3ZH8
6.3
-
KPCI_HUMAN
A:
[4-343]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
Q
-----
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
---
K
K
---
T
-
D
----
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
--
D
D
E
D
I
D
-
W
V
Q
T
E
K
H
V
F
-
E
---
Q
A
S
---
N
-
H
---
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
--
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
--
E
G
-
L
R
P
-
G
-
D
T
-
T
--
S
-
F
C
--
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
---
D
-----
Y
G
-
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
DIVG--------------
T
---
E
---
D
Y----
L
F
Q
V
I
L
--
E
K
------
Q
--
I
R
I
P
-----
R
S
---
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
------
H
P
-
Q
T
G
F
A
D
-
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
-----
N
I
S
G
E
F
G
L
D
N
F
--
D
S
Q
F
T
N
E
P
V
Q
L
------------------------------------
69
Blastp_CBE
49.85
47%
-31
- C1 -
-
5LIH
5.2
-
KPCI_HUMAN
A:
[4-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
Q
-----
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
---
K
K
---
T
-
D
----
R
I
Y
A
M
K
V
V
K
K
E
L
V
----------
W
V
Q
T
E
K
H
V
F
-
E
---
Q
A
S
---
N
-
H
---
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
--
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
--
E
G
-
L
R
P
-
G
-
D
T
-
T
--
S
-
F
C
--
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
---
D
-----
Y
G
-
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
DIV----------------NTE
D
---
Y
-----
L
F
Q
V
I
L
--
E
K
------
Q
--
I
R
I
P
-----
R
S
---
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
------
H
P
-
Q
T
G
F
A
D
-
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
-----
N
I
S
G
E
F
G
L
D
N
F
--
D
S
Q
F
T
N
E
P
V
Q
L
------------------------------------
64
Blastp_CBE
49.84
47%
-20
- C1 -
-
3ZH8
3.0
-
KPCI_HUMAN
C:
[4-341]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
Q
-----
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
---
K
K
---
T
-
D
----
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
--
D
D
E
D
I
D
-
W
V
Q
T
E
K
H
V
F
-
E
---
Q
A
S
---
N
-
H
---
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
--
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
--
E
G
-
L
R
P
-
G
-
D
T
-
T
--
S
-
F
C
--
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
---
D
-----
Y
G
-
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
DIVG--------------
T
---
E
---
D
Y----
L
F
Q
V
I
L
--
E
K
------
Q
--
I
R
I
P
-----
R
S
---
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
------
H
P
-
Q
T
G
F
A
D
-
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
-----
N
I
S
G
E
F
G
L
D
N
F
--
D
S
Q
F
T
N
E
P
V
Q
L
------------------------------------
523
Blastp_CBE
49.60
38%
-71
- C1 -
-
5LVP
4.7
-
PDPK1_HUMAN
D:
[33-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
-------------
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
G
---
L
-----
I
F
A
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
78
Blastp_CBE
49.58
47%
-25
- C1 -
-
3A8W
6.1
-
KPCI_HUMAN
A:
[8-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
Q
-----
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
---
K
K
---
T
-
D
----
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
------
I
D
-
W
V
Q
T
E
K
H
V
F
-
E
---
Q
A
S
---
N
-
H
---
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
--
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
--
E
G
-
L
R
P
-
G
-
D
T
-
T
--
S
-
F
C
--
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
---
D
-----
Y
G
-
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
DI--------------------
E
---
D
Y----
L
F
Q
V
I
L
--
E
K
------
Q
--
I
R
I
P
-----
R
S
---
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
------
H
P
-
Q
T
G
F
A
D
-
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
-----
N
I
S
G
E
F
G
L
D
N
F
--
D
S
Q
F
T
N
E
P
V
Q
L
------------------------------------
301
Blastp_CBE
49.51
43%
-51
- C1 -
-
3TNQ
5.4
-
KAPCA_MOUSE
B:
[32-329]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
246
Blastp_CBE
49.45
39%
-52
- C1 -
-
5VI9
6.4
-
KAPCA_BOVIN
A:
[15-351]
-----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
----
H
--------
L
---------------
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
----
N
F
--
D
-
D
Y
E
------------------------------------------
526
Blastp_CBE
49.42
38%
-74
- C1 -
-
5LVP
5.5
-
PDPK1_HUMAN
A:
[33-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
-------------
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
G
---
L
-----
I
F
A
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
65
Blastp_CBE
49.40
47%
-22
- C1 -
-
3ZH8
6.7
-
KPCI_HUMAN
B:
[4-342]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
Q
-----
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
---
K
K
---
T
-
D
----
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
--
D
D
E
D
I
D
-
W
V
Q
T
E
K
H
V
F
-
E
---
Q
A
S
---
N
-
H
---
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
--
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
--
E
G
-
L
R
P
-
G
-
D
T
-
T
--
S
-
F
C
--
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
---
D
-----
Y
G
-
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
DIVG--------------
T
---
E
---
D
Y----
L
F
Q
V
I
L
--
E
K
------
Q
--
I
R
I
P
-----
R
S
---
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
------
H
P
-
Q
T
G
F
A
D
-
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
-----
N
I
S
G
E
F
G
L
D
N
F
--
D
S
Q
F
T
N
E
P
V
Q
L
------------------------------------
289
Blastp_CBE
49.29
43%
-49
- C1 -
-
5JR7
4.7
-
KAPCA_MOUSE
C:
[32-329]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
----
Q
--
N
T
A
Q
--
L
----
D
-----
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
481
Blastp_CBE
49.00
38%
-71
- C1 -
-
5HKM
7.3
-
PDPK1_HUMAN
A:
[31-306]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
-------------
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
Y
---
L
-----
I
F
Q
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
107
Blastp_CBE
48.98
44%
23
- C1 -
-
4NUS
7.6
-
KS6A3_HUMAN
A:
[17-322]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
H
H
VKEG
H
--
E
K
A
D
--
P
----
S
-----
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
----
K
I
---
S
-
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
--
V
R
D
R
V
--
R
T
K
M
E
R
D
I
L
-
V
---
E
-
V
---
N
-
H
---
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
--
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
--
E
S
-
I
D
H
-
E
-
K
K
A
Y
--
S
-
F
C
--
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
-----
H
T
-
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
--
G
---
K
----
D
R
---
K
---
E
-----
T
M
T
M
I
L
--
K
A
------
K
--
L
G
M
P
-----
Q
F
---
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
A
------
G
P
-
D
G
V
-
E
E
-
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-----
A
------
T
F
Y
F
--
D
----------------------------------------------
453
Blastp_CBE
48.87
39%
-23
- C1 -
-
6BDL
3.0
-
KGP1_HUMAN
A:
[33-326]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
S
-----
D
F
N
I
I
D
T
L
G
V
G
-
G
F
G
R
V
E
L
V
Q
L
---
K
S
---
E
E
S
----
K
T
F
A
M
K
I
L
K
K
R
H
I
V
--
D
T
R
Q
Q
E
-
H
I
R
S
E
K
Q
I
M
-
Q
---
G
-
A
---
H
-
S
---
D
F
I
V
R
L
Y
R
T
F
K
D
S
K
Y
L
Y
M
L
M
E
A
C
L
G
G
E
L
W
T
I
L
R
D
--
R
G
S
F
E
D
S
T
T
R
F
Y
T
A
C
V
V
E
A
F
A
Y
L
H
S
-
K
G
--
I
I
Y
R
D
L
K
P
E
N
L
I
L
D
-
H
R
G
Y
A
K
L
V
D
F
G
F
A
K
--
K
---
I
G
-
F
-
G
K
K
T
--
W
-
F
C
--
G
T
P
E
Y
V
A
P
E
I
I
L
N
K
---
G
-----
H
D
-
I
S
A
D
Y
W
S
L
G
I
L
M
Y
E
L
L
T
G
-
S
P
P
F
-----
S
--
G
---
P
----
D
P
---
M
---
K
-----
T
Y
N
I
I
L
RG
I
D
------
M
--
I
E
F
P
-----
K
K
---
I
A
K
N
A
A
N
L
I
K
K
L
C
R
D
N
P
S
E
--
R
L
G
N
------
L
K
-
N
G
V
-
K
D
-
I
Q
K
H
K
W
F
E
G
F
N
---
W
E
G
L
R
K
G
T
L
T
P
P
I
I
P
-----
S
V
A
S
P
T
D
T
S
N
F
--
D
----------------------------------------------
447
Blastp_CBE
48.50
39%
-17
- C1 -
-
6C0T
6.3
-
A:
[33-326]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
S
-----
D
F
N
I
I
D
T
L
G
V
G
-
G
F
G
R
V
E
L
V
Q
L
---
K
S
---
E
E
S
----
K
T
F
A
M
K
I
L
K
K
R
H
I
V
--
D
T
R
Q
Q
E
-
H
I
R
S
E
K
Q
I
M
-
Q
---
G
-
A
---
H
-
S
---
D
F
I
V
R
L
Y
R
T
F
K
D
S
K
Y
L
Y
M
L
M
E
A
C
L
G
G
E
L
W
T
I
L
R
D
--
R
G
S
F
E
D
S
T
T
R
F
Y
T
A
C
V
V
E
A
F
A
Y
L
H
S
-
K
G
--
I
I
Y
R
D
L
K
P
E
N
L
I
L
D
-
H
R
G
Y
A
K
L
V
D
F
G
F
A
K
--
K
---
I
G
-
F
-
G
K
K
T
--
W
-
F
C
--
G
T
P
E
Y
V
A
P
E
I
I
L
N
K
---
G
-----
H
D
-
I
S
A
D
Y
W
S
L
G
I
L
M
Y
E
L
L
T
G
-
S
P
P
F
-----
S
--
G
---
P
----
D
P
---
M
---
K
-----
T
Y
N
I
I
L
RG
I
D
------
M
--
I
E
F
P
-----
K
K
---
I
A
K
N
A
A
N
L
I
K
K
L
C
R
D
N
P
S
E
--
R
L
G
N
------
L
K
-
N
G
V
-
K
D
-
I
Q
K
H
K
W
F
E
G
F
N
---
W
E
G
L
R
K
G
T
L
T
P
P
I
I
P
-----
S
V
A
S
P
T
D
T
S
N
F
--
D
----------------------------------------------
527
Blastp_CBE
48.39
38%
-65
- C1 -
-
5LVO
6.5
-
PDPK1_HUMAN
A:
[33-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
P
E
-
S
-
K
Q
A
R
--
A
N
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
G
---
L
-----
I
F
A
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
530
Blastp_CBE
48.27
38%
-61
- C1 -
-
5LVL
6.0
-
PDPK1_HUMAN
A:
[33-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
P
E
-
S
-
K
Q
A
R
--
A
N
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
G
---
L
-----
I
F
A
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
82
Blastp_CBE
47.98
45%
10
- C1 -
-
5D9K
6.9
-
KS6A3_HUMAN
A:
[26-323]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
D
--
P
----
S
-----
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
----
K
I
---
S
-
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
--
V
R
D
R
V
--
R
T
K
M
E
R
D
I
L
-
V
---
E
-
V
---
N
-
H
---
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
--
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
--------------------
C
--
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
-----
H
T
-
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
--
G
---
K
----
D
R
---
K
---
E
-----
T
M
T
M
I
L
--
K
A
------
K
--
L
G
M
P
-----
Q
F
---
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
A
------
G
P
-
D
G
V
-
E
E
-
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-----
A
------
T
F
Y
F
--
D
P
---------------------------------------------
531
Blastp_CBE
47.76
38%
-62
- C1 -
-
5ACK
6.0
-
PDPK1_HUMAN
A:
[33-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
P
E
-
S
-
K
Q
A
R
--
A
N
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
G
---
L
-----
I
F
A
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
73
Blastp_CBE
47.72
47%
-25
- C1 -
-
6ILZ
4.5
-
KPCI_HUMAN
C:
[11-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
----------
D
----
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
--
D
D
E
D
I
D
-
W
V
Q
T
E
K
H
V
F
-
E
---
Q
A
S
---
N
-
H
---
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
--
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
--
E
G
-
L
R
P
-
G
-
D
T
-
T
--
S
-
F
C
--
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
---
D
-----
Y
G
-
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
DI------------------------
D
Y----
L
F
Q
V
I
L
--
E
K
------
Q
--
I
R
I
P
-----
R
S
---
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
------
H
P
-
Q
T
G
F
A
D
-
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
-----
N
I
S
G
E
F
G
L
D
N
F
--
D
S
Q
F
--
E
P
V
Q
L
------------------------------------
81
Blastp_CBE
47.67
45%
12
- C1 -
-
5D9K
6.5
-
KS6A3_HUMAN
B:
[26-323]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
D
--
P
----
S
-----
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
----
K
I
---
S
-
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
--
V
R
D
R
V
--
R
T
K
M
E
R
D
I
L
-
V
---
E
-
V
---
N
-
H
---
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
--
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
--
E
-----------------
C
--
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
-----
H
T
-
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
--
G
---
K
----
D
R
---
K
---
E
-----
T
M
T
M
I
L
--
K
A
------
K
--
L
G
M
P
-----
Q
F
---
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
A
------
G
P
-
D
G
V
-
E
E
-
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
------------
T
F
Y
F
--
D
P
---------------------------------------------
536
Blastp_CBE
47.57
38%
-58
- C1 -
-
4A06
4.7
-
PDPK1_HUMAN
A:
[33-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
P
E
-
S
-
K
Q
A
R
--
A
N
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
G
---
L
-----
I
F
A
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
534
Blastp_CBE
47.64
38%
-61
- C1 -
-
4RQK
6.2
-
PDPK1_HUMAN
A:
[33-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
P
E
-
S
-
K
Q
A
R
--
A
N
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
G
---
L
-----
I
F
A
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
68
Blastp_CBE
47.63
47%
-15
- C1 -
-
5LIH
5.2
-
KPCI_HUMAN
B:
[4-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
Q
-----
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
---
K
K
---
T
-
D
----
R
I
Y
A
M
K
V
V
K
K
E
L
------------
V
Q
T
E
K
H
V
F
-
E
---
Q
A
S
---
N
-
H
---
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
--
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
--
E
G
-
L
R
P
-
G
-
D
T
-
T
--
S
-
F
C
--
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
---
D
-----
Y
G
-
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
DI-----------------E--
D
---
Y
-----
L
F
Q
V
I
L
--
E
K
------
Q
--
I
R
I
P
-----
R
S
---
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
------
H
P
-
Q
T
G
F
A
D
-
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
-----
N
I
S
G
E
F
G
L
D
N
F
--
D
S
Q
F
T
N
E
P
V
Q
L
------------------------------------
529
Blastp_CBE
47.57
38%
-63
- C1 -
-
5LVM
3.6
-
PDPK1_HUMAN
A:
[33-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
P
E
-
S
-
K
Q
A
R
--
A
N
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
G
---
L
-----
I
F
A
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
538
Blastp_CBE
47.56
38%
-60
- C1 -
-
3HRF
5.8
-
PDPK1_HUMAN
A:
[33-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
P
E
-
S
-
K
Q
A
R
--
A
N
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
G
---
L
-----
I
F
A
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
521
Blastp_CBE
47.55
38%
-63
- C1 -
-
4XX9
6.3
-
PDPK1_HUMAN
A:
[32-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
P
E
-
S
-
K
Q
A
R
--
A
N
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
G
---
L
-----
I
F
A
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
528
Blastp_CBE
47.53
38%
-62
- C1 -
-
5LVN
4.7
-
PDPK1_HUMAN
A:
[33-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
P
E
-
S
-
K
Q
A
R
--
A
N
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
G
---
L
-----
I
F
A
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
100
Blastp_CBE
47.52
47%
-27
- C1 -
-
1XJD
7.1
-
A:
[16-335]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
----
E
-----
D
F
I
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
F
---
K
K
---
T
-
N
----
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
--
M
D
D
D
V
E
-
C
T
M
V
E
K
R
V
L
-
S
---
L
-
A
W--
E
-
H
---
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
--
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
--
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
K
--
E
N
M
L
G
D
-
A
-
K
T
----
N
-
F
C
--
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
---
K
-----
Y
N
-
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
-
Q
S
P
F
-----
H
--
G
---
Q
----
D
E
---
E
---
E
-----
L
F
H
S
I
R
--
M
D
------
N
--
P
F
Y
P
-----
R
W
---
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
G
V
------
R
G
-
D
------
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
-----------------
N
F
--
D
K
E
F
L
-------
F
A
---------------------------------
539
Blastp_CBE
47.23
38%
-61
- C1 -
-
3HRC
5.8
-
PDPK1_HUMAN
A:
[33-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
P
------
A
R
--
A
N
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
G
---
L
-----
I
F
A
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
532
Blastp_CBE
47.23
38%
-62
- C1 -
-
4RRV
6.1
-
PDPK1_HUMAN
A:
[33-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
P
E
-
S
-
K
Q
A
R
--
A
N
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
G
---
L
-----
I
F
A
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
456
Blastp_CBE
47.18
37%
-53
- C1 -
-
1H1W
5.2
-
PDPK1_HUMAN
A:
[5-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
K
R
--
P
----
E
-----
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
P
------
A
R
--
A
N
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
Y
---
L
-----
I
F
Q
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
71
Blastp_CBE
47.12
47%
-10
- C1 -
-
6ILZ
3.8
-
KPCI_HUMAN
G:
[11-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
----------
D
----
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
--
D
D
E
D
I
D
-
W
V
Q
T
E
K
H
V
F
-
E
---
Q
A
S
---
N
-
H
---
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
--
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
--
E
G
-
L
R
P
-
G
-
D
T
-
T
--
S
-
F
C
--
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
---
D
-----
Y
G
-
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
DIV-----------------------
D
Y----
L
F
Q
V
I
L
--
E
K
------
Q
--
I
R
I
P
-----
R
S
---
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
------
H
P
-
Q
T
G
F
A
D
-
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
-----
N
I
S
---
G
L
D
N
F
--
D
S
Q
F
T
--
P
V
Q
L
------------------------------------
537
Blastp_CBE
46.97
38%
-56
- C1 -
-
3RCJ
6.4
-
PDPK1_HUMAN
A:
[33-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
P
E
-
S
-
K
Q
A
R
--
A
N
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
G
---
L
-----
I
F
A
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
533
Blastp_CBE
46.87
38%
-58
- C1 -
-
4RQV
6.3
-
PDPK1_HUMAN
A:
[33-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
P
E
-
S
-
K
Q
A
R
--
A
N
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
G
---
L
-----
I
F
A
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
504
Blastp_CBE
46.71
38%
-60
- C1 -
-
3RWQ
6.9
-
PDPK1_HUMAN
A:
[33-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
P
------
A
R
--
A
N
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
Y
---
L
-----
I
F
Q
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
455
Blastp_CBE
46.35
37%
-52
- C1 -
-
1UVR
3.5
-
PDPK1_HUMAN
A:
[5-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
K
R
--
P
----
E
-----
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
---
L
A
---
T
-
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
--
K
E
N
K
V
P
-
Y
V
T
R
E
R
D
V
M
-
S
---
R
-
L
---
D
-
H
---
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
--
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
--
V
L
-
S
P
------
A
R
--
A
N
F
V
--
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
-
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
--
A
---
G
----
N
E
---
Y
---
L
-----
I
F
Q
K
I
I
--
K
L
------
E
--
Y
D
F
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
EEMEGY
G
P
-
L
K
A
-------
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
103
Blastp_CBE
45.51
45%
7
- C1 -
-
2Z7Q
5.2
-
KS6A1_HUMAN
A:
[24-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
D
--
P
----
S
-----
H
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
---
V
T
RPD
S
-
G
----
H
L
Y
A
M
K
V
L
----------------------
I
L
-
A
---
D
-
V
---
N
-
H
---
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
--
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
--
E
--------------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
Q
---
G
-----
H
S
-
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
-
S
L
P
F
-----
Q
--
G
---
K
----
D
R
---
K
---
E
-----
T
M
T
L
I
L
--
K
A
------
K
--
L
G
M
P
-----
Q
F
---
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
--
R
L
G
S
------
G
P
-
D
G
A
-
E
E
-
I
K
R
H
V
F
Y
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
-----------------------------------------------------------------
72
Blastp_CBE
44.96
47%
-29
- C1 -
-
6ILZ
5.2
-
KPCI_HUMAN
E:
[12-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
----------
D
----
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
--
D
D
E
D
I
D
-
W
V
Q
T
E
K
H
V
F
-
E
---
Q
A
S
---
N
-
H
---
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
--
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
--
E
G
-
L
R
P
-
G
-
D
T
-
T
--
S
-
F
C
--
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
---
D
-----
Y
G
-
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
DI------------------------
D
Y----
L
F
Q
V
I
L
--
E
K
------
Q
--
I
R
I
P
-----
R
S
---
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
------
H
P
-
Q
T
G
F
A
D
-
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
-----
N
I
S
G
E
F
G
L
D
N
F
--
D
S
Q
F
T
--
P
V
Q
L
------------------------------------
98
Blastp_CBE
44.92
46%
16
- C1 -
-
3G51
7.6
-
KS6A3_MOUSE
A:
[18-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------
H
--
E
K
A
D
--
P
----
S
-----
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
----
K
I
---
S
-
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
--
V
-----------
R
D
I
L
-
V
---
E
-
V
---
N
-
H
---
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
--
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
--
E
S
-
I
------------------
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
-----
H
T
-
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
--
G
---
K
----
D
R
---
K
---
E
-----
T
M
T
M
I
L
--
K
A
------
K
--
L
G
M
P
-----
Q
F
---
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
A
------
G
P
-
D
G
V
-
E
E
-
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-----------------------------------------------------------------
118
Blastp_CBE
44.88
46%
17
- C1 -
-
3UBD
6.8
-
KS6A3_MOUSE
A:
[18-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------
H
--
E
K
A
D
--
P
----
S
-----
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
----
K
I
---
S
-
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
--
V
R
D
R
V
--------
D
I
L
-
V
---
E
-
V
---
N
-
H
---
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
--
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
---------
E
-
K
K
A
Y
--
S
-
F
C
--
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
-----
H
T
-
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
--
G
---
K
----
D
R
---
K
---
E
-----
T
M
T
M
I
L
--
K
A
------
K
--
L
G
M
P
-----
Q
F
---
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
A
------
G
P
-
D
G
V
-
E
E
-
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-----------------------------------------------------------------
117
Blastp_CBE
44.80
46%
22
- C1 -
-
4EL9
6.6
-
KS6A3_MOUSE
A:
[19-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------
H
--
E
K
A
D
--
P
----
S
-----
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
----
K
I
---
S
-
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
--
V
R
D
R
V
-------
R
D
I
L
-
V
---
E
-
V
---
N
-
H
---
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
--
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
--
E
S
-----
E
-
K
K
A
Y
--
S
-
F
C
--
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
-----
H
T
-
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
--
G
---
K
----
D
R
---
K
---
E
-----
T
M
T
M
I
L
--
K
A
------
K
--
L
G
M
P
-----
Q
F
---
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
A
------
G
P
-
D
G
V
-
E
E
-
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-----------------------------------------------------------------
101
Blastp_CBE
44.66
45%
7
- C1 -
-
2Z7S
6.7
-
KS6A1_HUMAN
A:
[24-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
D
--
P
----
S
-----
H
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
---
V
T
RPD
S
-
G
----
H
L
Y
A
M
K
V
L
K
---------------------
I
L
-
A
---
D
-
V
---
N
-
H
---
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
--
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
--
E
--------------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
Q
---
G
-----
H
S
-
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
-
S
L
P
F
-----
Q
--
G
---
K
----
D
R
---
K
---
E
-----
T
M
T
L
I
L
--
K
A
------
K
--
L
G
M
P
-----
Q
F
---
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
--
R
L
G
S
------
G
P
-
D
G
A
-
E
E
-
I
K
R
H
V
F
Y
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
-----------------------------------------------------------------
104
Blastp_CBE
44.54
44%
43
- C1 -
-
5D9L
5.2
-
KS6A3_HUMAN
A:
[13-322]
----------------------------------------------------------------------------------------------------------------------------------------------
E
I
-
A
I
T
H
H
VKEG
H
--
E
K
A
D
--
P
----
S
-----
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
----
K
I
---
S
-
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
--
V
R
D
R
V
--
R
T
K
M
E
R
D
I
L
-
V
---
E
-
V
---
N
-
H
---
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
--
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
--
E
--------------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
-----
H
T
-
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
--
G
---
K
----
D
R
---
K
---
E
-----
T
M
T
M
I
L
--
K
A
------
K
--
L
G
M
P
-----
Q
F
---
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
A
------
G
P
-
D
G
V
-
E
E
-
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-----
A
T
G
R
P
E
D
T
F
Y
F
--
D
----------------------------------------------
116
Blastp_CBE
44.46
46%
19
- C1 -
-
4GUE
7.5
-
KS6A3_MOUSE
A:
[19-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------
H
--
E
K
A
D
--
P
----
S
-----
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
----
K
I
---
S
-
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
--
V
R
D
R
V
----------
L
-
V
---
E
-
V
---
N
-
H
---
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
--
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
---------
E
-
K
K
A
Y
--
S
-
F
C
--
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
-----
H
T
-
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
--
G
---
K
----
D
R
---
K
---
E
-----
T
M
T
M
I
L
--
K
A
------
K
--
L
G
M
P
-----
Q
F
---
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
A
------
G
P
-
D
G
V
-
E
E
-
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-----------------------------------------------------------------
102
Blastp_CBE
44.30
45%
16
- C1 -
-
2Z7R
7.6
-
KS6A1_HUMAN
A:
[21-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------GS
E
K
A
D
--
P
----
S
-----
H
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
---
V
T
RPD
S
-
G
----
H
L
Y
A
M
K
V
L
K
K
A
T
L
K
--
V
-------------
I
L
-
A
---
D
-
V
---
N
-
H
---
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
--
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
--
E
--------------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
Q
---
G
-----
H
S
-
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
-
S
L
P
F
-----
Q
--
G
---
K
----
D
R
---
K
---
E
-----
T
M
T
L
I
L
--
K
A
------
K
--
L
G
M
P
-----
Q
F
---
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
--
R
L
G
S
------
G
P
-
D
G
A
-
E
E
-
I
K
R
H
V
F
Y
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
-----------------------------------------------------------------
74
Blastp_CBE
44.26
47%
-1
- C1 -
-
6ILZ
4.0
-
KPCI_HUMAN
A:
[11-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
----------
D
----
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
--
D
D
E
D
I
D
-
W
V
Q
T
E
K
H
V
F
-
E
---
Q
A
S
---
N
-
H
---
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
--
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
--
E
G
-
L
R
P
-
G
-
D
T
-
T
--
S
-
F
C
--
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
---
D
-----
Y
G
-
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
DIV-----------------------
D
Y----
L
F
Q
V
I
L
--
E
K
------
Q
--
I
R
I
P
-----
R
S
---
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
------
H
P
-
Q
T
G
F
A
D
-
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
-----
N
I
S
G
E
F
G
L
D
N
F
--
D
S
Q
F
T
N
E
P
V
Q
L
------------------------------------
91
Blastp_CBE
44.20
48%
8
- C1 -
-
3A62
9.3
-
KS6B1_HUMAN
A:
[19-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
----------------
A
E
R
N
I
L
-
E
---
E
-
V
---
K
-
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
--
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
--
E
----------------
F
C
--
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
---
G
-----
H
N
-
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
--
G
---
E
----
N
R
---
K
---
K
-----
T
I
D
K
I
L
--
K
C
------
K
--
L
N
L
P
-----
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
------
G
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----
L
-----------------------------------------------------------
287
Blastp_CBE
43.65
43%
32
- C1 -
-
6G77
7.6
-
KS6A6_HUMAN
A:
[16-307]
----------------------------------------------------------------------------------------------------------------------------------------------------
T
H
----
H
--
V
K
E
G
--
Y
----
E
KADPA
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
---
K
T
GPD
A
-
G
----
Q
L
Y
A
M
K
V
L
K
K
A
S
L
K
--
V
R
D
----------
D
I
L
-
V
---
E
-
V
---
N
-
H
---
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
--
E
V
L
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
--
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
I
G
H
I
K
L
T
D
F
G
L
S
K
--
E
S
-
V
D
Q
-
E
-
K
K
A
Y
--
S
-
F
C
--
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
-----
H
S
-
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
--
G
---
K
----
D
R
---
N
---
E
-----
T
M
N
M
I
L
--
K
A
------
K
--
L
G
M
P
-----
Q
F
---
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
S
---------
E
G
V
-
E
E
-
I
K
R
H
L
F
F
A
N
I
D
---
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
-----------------------------------------------------------------
328
Blastp_CBE
43.43
43%
27
- C1 -
-
6G78
6.7
-
KS6A6_HUMAN
B:
[16-307]
----------------------------------------------------------------------------------------------------------------------------------------------------
T
H
----
H
--
V
K
E
G
--
Y
----
E
KADPA
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
---
K
T
GPD
A
-
G
----
Q
L
Y
A
M
K
V
L
K
K
A
S
L
K
--
V
R
D
----------
D
I
L
-
V
---
E
-
V
---
N
-
H
---
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
--
E
V
L
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
--
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
I
G
H
I
K
L
T
D
F
G
L
S
K
--
E
S
-
V
-----------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
-----
H
S
-
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
--
G
---
K
----
D
R
---
N
---
E
-----
T
M
N
M
I
L
--
K
A
------
K
--
L
G
M
P
-----
Q
F
---
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
S
---------
E
G
V
-
E
E
-
I
K
R
H
L
F
F
A
N
I
D
---
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
-----------------------------------------------------------------
415
Blastp_CBE
43.33
40%
27
- C1 -
-
4WB7
8.7
-
DNJB1_HUMAN (first)
B:
[42-384]
----------------------------------------------------------------------------------------------
E
K
F
K
E
I
A
E
A
Y
D
V
L
S
D
P
R
K
----
R
E
IFDRY
G
E
E
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
416
Blastp_CBE
43.31
40%
33
- C1 -
-
4WB7
8.7
-
DNJB1_HUMAN (first)
A:
[42-384]
----------------------------------------------------------------------------------------------
E
K
F
K
E
I
A
E
A
Y
D
V
L
S
D
P
R
K
----
R
E
IFDRY
G
E
E
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
----
H
--------
L
----
D
-----
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
-
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
--
K
L
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
-
Q
---
A
-
V
---
N
-
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
--
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
------
V
-
K
G
R
T
--
W
-
L
C
--
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
--
A
---
D
----
Q
P
---
I
---
Q
-----
I
Y
E
K
I
V
--
S
G
------
K
--
V
R
F
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
N
------
L
K
-
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
--
D
D
---------------------------------------------
286
Blastp_CBE
42.99
43%
32
- C1 -
-
6G77
7.4
-
KS6A6_HUMAN
B:
[16-307]
----------------------------------------------------------------------------------------------------------------------------------------------------
T
H
----
H
--
V
K
E
G
--
Y
----
E
KADPA
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
---
K
T
GPD
A
-
G
----
Q
L
Y
A
M
K
V
L
K
K
A
S
L
K
--
V
R
D
----------
D
I
L
-
V
---
E
-
V
---
N
-
H
---
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
--
E
V
L
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
--
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
I
G
H
I
K
L
T
D
F
G
L
S
K
--
E
S
-
V
D
Q
-
E
-
K
K
A
Y
--
S
-
F
C
--
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
-----
H
S
-
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
--
G
---
K
----
D
R
---
N
---
E
-----
T
M
N
M
I
L
--
K
A
------
K
--
L
G
M
P
-----
Q
F
---
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
S
---------
E
G
V
-
E
E
-
I
K
R
H
L
F
F
A
N
I
D
---
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
-----------------------------------------------------------------
93
Blastp_CBE
42.80
48%
10
- C1 -
-
3WF8
7.6
-
KS6B1_HUMAN
A:
[21-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
RN
A
K
D
-
T
A
-
H
T
K
A
E
R
N
I
L
-
E
---
E
-
V
---
K
-
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
--
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
--
E
S
-
I
H
D
-
G
--
T
V
T
--
H
-
F
C
--
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
---
G
-----
H
N
-
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
--
G
---
E
----
N
R
---
K
---
K
-----
T
I
D
K
I
L
--
K
C
------
K
--
L
N
L
P
-----
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
------
G
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----
L
L
----------------------------------------------------------
329
Blastp_CBE
42.73
43%
28
- C1 -
-
6G78
8.9
-
KS6A6_HUMAN
A:
[16-307]
----------------------------------------------------------------------------------------------------------------------------------------------------
T
H
----
H
--
V
K
E
G
--
Y
----
E
KADPA
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
---
K
T
GPD
A
-
G
----
Q
L
Y
A
M
K
V
L
K
K
A
S
L
K
--
V
R
D
----------
D
I
L
-
V
---
E
-
V
---
N
-
H
---
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
--
E
V
L
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
--
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
I
G
H
I
K
L
T
D
F
G
L
S
K
--
E
S
-
V
D
Q
---------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
-----
H
S
-
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
--
G
---
K
----
D
R
---
N
---
E
-----
T
M
N
M
I
L
--
K
A
------
K
--
L
G
M
P
-----
Q
F
---
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
S
---------
E
G
V
-
E
E
-
I
K
R
H
L
F
F
A
N
I
D
---
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
-----------------------------------------------------------------
59
Blastp_CBE
42.28
48%
11
- C1 -
-
3A60
8.7
-
KS6B1_HUMAN
A:
[19-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
A
M
-------------
K
A
E
R
N
I
L
-
E
---
E
-
V
---
K
-
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
--
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
--
E
---------------------
T
I
E
Y
M
A
P
E
I
L
M
R
S
---
G
-----
H
N
-
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
--
G
---
E
----
N
R
---
K
---
K
-----
T
I
D
K
I
L
--
K
C
------
K
--
L
N
L
P
-----
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
------
G
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----------------------------------------------------------------
95
Blastp_CBE
41.95
48%
4
- C1 -
-
3WF6
6.6
-
KS6B1_HUMAN
A:
[21-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
--------------
T
K
A
E
R
N
I
L
-
E
---
E
-
V
---
K
-
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
--
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
--
E
S
-
I
H
D
-
G
--
T
V
T
--
H
-
F
C
--
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
---
G
-----
H
N
-
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
--
G
---
E
----
N
R
---
K
---
K
-----
T
I
D
K
I
L
--
K
C
------
K
--
L
N
L
P
-----
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
------
G
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----
L
L
Q
S
--------------------------------------------------------
420
Blastp_CBE
41.90
44%
10
- C1 -
-
6G76
6.8
-
KS6A6_HUMAN
B:
[16-307]
----------------------------------------------------------------------------------------------------------------------------------------------------
T
H
----
H
--
V
K
E
G
--
Y
----
E
KADPA
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
---
K
T
GPD
A
-
G
----
Q
L
Y
A
M
K
V
L
K
K
A
S
L
K
--
V
-----------
R
D
I
L
-
V
---
E
-
V
---
N
-
H
---
P
F
I
V
K
L
H
Y
A
F
Q
T
--
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
--
E
V
L
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
--
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
I
G
H
I
K
L
T
D
F
G
L
S
K
--
E
S
-
V
-
D
-----------------
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
-----
H
S
-
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
--
G
---
K
----
D
R
---
N
---
E
-----
T
------------------
L
G
M
P
-----
Q
F
---
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
S
---------
E
G
V
-
E
E
-
I
K
R
H
L
F
F
A
N
I
D
---
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
-----------------------------------------------------------------
96
Blastp_CBE
41.84
48%
5
- C1 -
-
3WF5
6.8
-
KS6B1_HUMAN
A:
[21-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
--------------
T
K
A
E
R
N
I
L
-
E
---
E
-
V
---
K
-
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
--
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
--
E
S
-
I
H
D
-
G
--
T
V
T
--
H
-
F
C
--
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
---
G
-----
H
N
-
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
--
G
---
E
----
N
R
---
K
---
K
-----
T
I
D
K
I
L
--
K
C
------
K
--
L
N
L
P
-----
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
------
G
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----
L
L
Q
S
--------------------------------------------------------
58
Blastp_CBE
41.57
48%
17
- C1 -
-
3A60
9.3
-
KS6B1_HUMAN
B:
[19-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
---------------------------------
K
-
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
--
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
--
E
S
----------------
C
--
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
---
G
-----
H
N
-
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
--
G
---
E
----
N
R
---
K
---
K
-----
T
I
D
K
I
L
--
K
C
------
K
--
L
N
L
P
-----
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
------
G
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----
L
-----------------------------------------------------------
92
Blastp_CBE
41.38
48%
10
- C1 -
-
3WF9
7.5
-
KS6B1_HUMAN
A:
[21-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
RN
A
K
D
-
T
A
-
H
T
K
A
E
R
N
I
L
-
E
---
E
-
V
---
K
-
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
--
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
--
E
S
-
I
H
D
-
G
--
T
V
T
--
H
-
F
C
--
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
---
G
-----
H
N
-
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
--
G
---
E
----
N
R
---
K
---
K
-----
T
I
D
K
I
L
--
K
C
------
K
--
L
N
L
P
-----
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
------
G
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----
L
L
----------------------------------------------------------
114
Blastp_CBE
41.07
48%
21
- C1 -
-
4RLO
9.1
-
KS6B1_HUMAN
B:
[7-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
K
K
---------------------------------
K
-
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
--
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
--
E
S
-
I
------------------
T
I
E
Y
M
A
P
E
I
L
M
R
S
---
G
-----
H
N
-
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
--
G
---
E
----
N
R
---
K
---
K
-----
T
I
D
K
I
L
--
K
C
------
K
--
L
N
L
P
-----
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
------
G
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----------------------------------------------------------------
57
Blastp_CBE
40.72
48%
14
- C1 -
-
3A61
7.5
-
KS6B1_HUMAN
A:
[19-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
-
G
----
K
I
F
A
M
K
V
L
-----------------
K
A
E
R
N
I
L
-
E
---
E
-
V
---
K
-
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
--
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
--------------------------
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
---
G
-----
H
N
-
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
--
G
---
E
----
N
R
---
K
---
K
-----
T
I
D
K
I
L
--
K
C
------
K
--
L
N
L
P
-----
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
A
------
G
P
-
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----------------------------------------------------------------
421
Blastp_CBE
39.73
44%
20
- C1 -
-
6G76
6.1
-
KS6A6_HUMAN
A:
[16-307]
----------------------------------------------------------------------------------------------------------------------------------------------------
T
H
----
H
--
V
K
E
G
--
Y
----
E
KADPA
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
---
K
T
GPD
A
-
G
----
Q
L
Y
A
M
K
V
L
K
K
A
S
L
K
--
V
R
D
----------
D
I
L
-
V
---
E
-
V
---
N
-
H
---
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
--
E
V
L
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
--
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
I
G
H
I
K
L
T
D
F
G
L
S
K
--
E
S
-
V
-
D
-
Q
-
E
K
K
A
--
Y
-
F
C
--
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
-----
H
S
-
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
--
G
---
K
----
D
R
---
N
---
E
-----
T
M
N
M
I
L
--
K
A
------
K
--
L
G
M
P
-----
Q
F
---
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
S
---------
E
G
V
-
E
E
-
I
K
R
H
L
F
F
A
N
I
D
---
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
-----------------------------------------------------------------
79
Blastp_CBE
27.41
42%
37
- C1 -
-
3PFQ
Error
-
KPCB_RAT
A:
[146-643]
----------------------------------------------------------------------------------------
F
N
V
P
-
P
P
E
G
S
E
G
N
E
E
L
R
Q
K
F
E
R
A
K
IGQG
T
K
-----
A
P
E
E
K
T
A
N
T
I
S
K
F
D
N
N
G
N
R
D
---------------
R
M
K
--
L
----
T
-----
D
F
N
F
L
M
V
L
G
K
G
-
S
F
G
K
V
M
L
S
E
R
---
K
G
---
T
-
D
----
E
L
Y
A
V
K
I
L
K
K
D
V
V
I
--
Q
D
D
D
V
E
-
C
T
M
V
E
K
R
V
L
-
A
L--
P
-
G
---
K
-
P
---
P
F
L
T
Q
L
H
S
C
F
Q
T
M
D
R
L
Y
F
V
M
E
Y
V
N
G
G
D
L
M
Y
H
I
Q
Q
--
V
G
R
F
K
E
P
H
A
V
F
Y
A
A
E
I
A
I
G
L
F
F
L
Q
S
-
K
G
--
I
I
Y
R
D
L
K
L
D
N
V
M
L
D
-
S
E
G
H
I
K
I
A
D
F
G
M
C
K
--
E
N
-
I
W
D
-
G
-
V
T
T
K
----
F
C
--
G
T
P
D
Y
I
A
P
E
I
I
A
Y
Q
---
P
-----
Y
G
-
K
S
V
D
W
W
A
F
G
V
L
L
Y
E
M
L
A
G
-
Q
A
P
F
-----
E
--
G
---
E
----
D
E
---
D
---
E
-----
L
F
Q
S
I
M
--
E
H
------
N
--
V
A
Y
P
-----
K
S
---
M
S
K
E
A
V
A
I
C
K
G
L
M
T
K
H
P
G
K
--
R
L
G
C
------
G
P
-
E
G
E
-
R
D
-
I
K
E
H
A
F
F
R
Y
I
D
---
W
E
K
L
E
R
K
E
I
Q
P
P
Y
K
P
-----
K
A
S
G
R
-
N
A
E
N
F
--
D
R
F
F
T
R
H
P
P
V
L
P
P
----------------------------------
-
* C *
-
:
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-
* C *
-
:
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-
* C *
-
:
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-
* C *
-
:
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-
* C *
-
:
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-
* C *
-
:
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