@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Screening
Virtual Screening Score
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ALK_HUMAN: (2020-09-04 )
MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP
Atome Classification :
(391 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......--1040......1050......1060...---...1070......1080......1090......1100.....-.-1110......1120........1130.-.---....-1140.--.-..-.---...1150-.-......1160-......1170.-..-...1180--....-....-1190-----.......1200......------1210---.-------.----.------.--------.--..---------1220----..---.......1230......1240......1250......1260--......1270..---....1280.-.....1290......1300......1310......1320.-.....1330.-.-...-..1340.-------.....1350......1360......1370......1380-.....----...-1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570......1580......1590......1600......1610......1620
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(pKd)
(pKd)
(Uniprot)
MGA
I
G
L
L
W
L
L
P
L
L
L
S
T
A
AVGSGMGTGQRAGSPAAGPPLQPREPL
S
Y
S
R
L
Q
R
K
S
L
A
V
D
F
V
V
P
S
L
F
R
V
Y
A
R
D
LLLPPSSSELKAGRPEARGSLAL
D
C
A
P
L
L
R
LLGPAPGVSWTAGSPAP
A
E
A
R
T
L
S
R
V
L
KGG
S
V
R
K
L
R
R
A
K
Q
L
V
L
E
L
G
E
E
A
I
L
E
GCVGPP
G
E
A
A
V
G
L
L
Q
F
N
L
S
E
L
F
S
W
W
I
RQGE
G
R
L
R
I
R
LMP
E
K
K
A
S
E
VGREGR
L
S
A
A
IRASQ
P
R
L
L
F
Q
I
FGTGHSSLESPTNMPSPSP
D
Y
F
T
W
N
L
T
W
I
MKDSF
P
F
L
SHRSRYGLECSFDFPCELEYSP
P
L
H
D
L
RNQSWSWRRIP
S
E
E
ASQMDLLDGPGAERSKEMPRG
S
F
L
L
L
NTSADSKHT
I
L
S
P
W
M
RSSSE
H
C
T
L
A
V
S
V
H
RHLQPS
G
R
Y
I
A
Q
LLPH
N
E
A
A
R
E
I
L
L
MPTPGKHG
W
T
V
LQGRIGRPDN
P
F
R
V
A
L
E
Y
I
SSGNRS
L
S
A
V
D
F
F
A
LKNCSEGTSPGS
K
M
A
L
QSSFTCWN
G
T
V
L
QLGQAC
D
F
H
Q
D
CAQGE
D
E
S
Q
M
C
R
KLP
V
G
F
Y
C
NFEDGFCGWTQGTLSPHTPQ
W
Q
V
R
TLKDARFQDHQD
H
A
L
L
L
S
TTDVPASESA
T
V
TSATFPAPIKSS
P
C
E
L
R
M
S
W
L
I
R
G
V
LRG
N
V
S
L
V
L
V
ENKTGKEQG
R
M
V
W
H
V
A
A
YE
G
L
S
L
W
Q
W
M
V
L
P
L
LDV
S
D
R
F
W
L
Q
M
V
A
W
WGQG
S
R
A
I
V
A
F
D
N
I
S
I
S
L
D
C
Y
L
T
ISGED
K
I
L
QNTAPKSRNLFERNPNKELKPGENSPRQTPIFDP
T
V
H
W
L
F
TTCGASGPHGPT
Q
A
Q
CNNAYQNS
N
L
S
V
E
VGSEGPLK
G
I
Q
I
W
KVPAT
D
T
Y
S
I
SGYGAAGGKGGKN
T
M
MRSHG
V
S
V
L
G
I
F
NLEKD
D
M
L
Y
I
L
VGQQGEDACP
S
T
N
Q
L
I
Q
K
V
CIGENN
V
I
E
E
E
I
R
VNR
S
V
H
EWAGGGGGGGG
A
T
Y
V
F
KMKDGVP
V
P
L
I
I
A
AGGGGRAYGAKTDTF
H
P
E
RLENNS
S
V
L
G
LNGNSGAAGGGGGWNDNT
S
L
L
WAGK
S
L
QEGATGGH
S
C
P
Q
A
M
K
KWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDG
V
S
F
I
S
P
L
G
I
L
Y
T
P
A
L
K
V
MEGHG
E
V
N
I
K
H
Y
LNCSHCE
V
D
E
CHMDPES
H
K
V
I
C
F
CDHG
T
V
L
A
EDG
V
S
C
I
VSPTPEPHL
P
L
S
L
I
L
S
V
--
V
T
S
A
L
V
A
A
L
V
L
A
F
S
G
I
M
I
V
Y
R
R
K
H
Q
E
L
---
Q
A
M
Q
M
E
LQSP
E
Y
K
L
S
K
L
R
T
S
T
I
MTDYNP
N
Y
C
FAGKTS
S
I
S
D
L
-
K
-EVPRKN
I
T
L
I
R
G--LGHGAFGEVYEGQ-V---SGMP-ND--P--
S
-
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
CSE
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
KF-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
L
MAGG
D
L
K
S
F
L
R
------ETR----P-------R----P------S--------Q--P
S
---------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
EN
H
F
I
H
R
D
IAAR
N
C
L
L
TCPGPG--
R
V
A
KIGDF
G
M
A
R
---
D
I
Y
R
A
S
YYR-KGG
C
A
MLPVKWM
P
P
E
A
F
M
E
G
I
FTSKTDT
W
S
F
G
V
L
L
W
E
I
F
S-LGYMPYPS-K-S-
N
Q
E
-
V
L
E
F
V
T
S-------GGRMDPPKNCP
G
P
V
Y
R
I
M
T
Q
C
W
QHQPEDRP
N
F
A
I
I
L
E
---
R
I
E
Y
C----TQD-PDVINTALPIEYGPLVEEEEKVPVRPKDPEGVP
P
L
L
V
S
Q
Q
A
K
R
E
EERSPAAPPPLPTTSSGKAAKKPT
A
A
E
I
S
V
RVPRGPAVEGG
H
V
N
M
A
FSQSN
P
P
S
E
L
H
K
VHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPG
A
S
L
L
LEPSSLTANMKEV
P
L
F
R
LRHFPCGNVNYGYQQQGLPLEAATAPGAGH
Y
E
D
T
I
LKSKNSMNQPGP
15
PsiBlast_PDB
94.66
99%
-129
- C2 -
-
5IUI
8.0
-
A:
[6-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
D
Y
N
P
N
Y
S
F
A
G
K
T
S
S
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
---
S
G
-------
P
--
S
-
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
----
P
------
S
--------
Q
--
P
S
---------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
A
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
94.43
99%
-126
- C2 -
-
4FNW
-
-
A:
[1-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
S
T
I
M
T
D
Y
N
P
N
Y
S
F
A
G
K
T
S
S
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
G
----
G
E
V
Y
E
G
Q
-
V
---
S
-----------
S
-
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
L
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
----
P
------
S
--------
Q
--
P
S
---------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
---------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
Y
G
P
L
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
94.06
99%
-125
- C2 -
-
3LCS
8.9
-
A:
[30-333]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
C
F
A
G
K
T
S
S
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
---
S
G
M
P
-
N
D
--
P
--
S
-
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
----
P
------
S
--------
Q
--
P
S
---------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
A
G
Y
Y
R
-
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
93.72
99%
-125
- C2 -
-
4FOD
10.1
-
A:
[8-328]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
S
T
I
M
T
D
Y
N
P
N
Y
S
F
A
G
K
T
S
S
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
---
S
-----------
S
-
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
----
P
------
S
--------
Q
--
P
S
---------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
A
--------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
Y
G
P
L
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
93.38
100%
-130
- C2 -
-
3AOX
8.7
-
A:
[19-334]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
I
M
T
D
Y
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
G
----
G
E
V
Y
E
G
Q
-
V
---------------
S
-
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
----
P
------
S
--------
Q
--
P
S
---------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
A
--------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
93.31
99%
-124
- C2 -
-
4MKC
9.4
-
A:
[50-358]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
---
S
-----------
S
-
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
----
P
------
S
--------
Q
--
P
S
---------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
A
G
Y
Y
R
-
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
93.28
99%
-121
- C2 -
-
3LCT
3.7
-
A:
[27-334]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
---
S
G
M
P
-
N
D
--
P
--
S
-
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
----
P
------
S
--------
Q
--
P
S
---------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
A
G
Y
Y
R
-
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
Blastp_CBE
93.16
99%
-129
- C2 -
-
4CMO
6.3
-
A:
[9-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
-----------------
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
----
P
------
S
--------
Q
--
P
S
---------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
-------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
93.07
99%
-122
- C2 -
-
3L9P
2.6
-
A:
[50-357]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
---
S
G
----------
S
-
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
----
P
------
S
--------
Q
--
P
S
---------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
A
G
Y
Y
R
-
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
Blastp_CBE
92.90
99%
-131
- C2 -
-
5AAA
7.1
-
A:
[9-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
-----------------
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
F
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
----
P
------
S
--------
Q
--
P
S
---------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
-------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Blastp_CBE
92.71
99%
-130
- C2 -
-
4CMU
7.3
-
A:
[9-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
-----------------
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
----
P
------
S
--------
Q
--
P
S
---------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
-------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
Blastp_CBE
91.93
99%
-133
- C2 -
-
5AA9
7.2
-
A:
[9-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
-----------------
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
F
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
----
P
------
S
--------
Q
--
P
S
---------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
-------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Blastp_CBE
91.86
100%
-131
- C2 -
-
5FTO
9.8
-
A:
[2-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
---
S
G
M
---------
S
-
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
----
P
------
S
--------
Q
--
P
S
---------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
--------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
Blastp_CBE
91.83
99%
-130
- C2 -
-
4ANQ
7.4
-
A:
[24-332]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
--
G
A
F
G
E
V
Y
E
G
Q
-
V
-----------------
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
----
P
------
S
--------
Q
--
P
S
---------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
A
D
F
G
M
A
R
---
D
I
Y
R
-------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Blastp_CBE
91.80
99%
-131
- C2 -
-
5AA8
7.5
-
A:
[9-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
G
H
---
G
E
V
Y
E
G
Q
-
V
-----------------
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
Y
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
F
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
----
P
------
S
--------
Q
--
P
S
---------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
-------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Blastp_CBE
91.72
99%
-132
- C2 -
-
4ANS
7.3
-
A:
[24-332]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
--
G
A
F
G
E
V
Y
E
G
Q
-
V
-----------------
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
----
P
------
S
--------
Q
--
P
S
---------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
A
D
F
G
M
A
R
---
D
I
Y
R
-------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Blastp_CBE
91.70
99%
-131
- C2 -
-
4CTC
7.9
-
A:
[10-317]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
G
----
G
E
V
Y
E
G
Q
-
V
-----------------
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
----
P
------
S
--------
Q
--
P
S
---------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
---------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
Blastp_CBE
91.64
99%
-131
- C2 -
-
2YFX
7.2
-
A:
[9-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
--
G
A
F
G
E
V
Y
E
G
Q
-
V
-----------------
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
----
P
------
S
--------
Q
--
P
S
---------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
-------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Blastp_CBE
91.55
99%
-131
- C2 -
-
4CTB
8.6
-
A:
[9-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
G
---
F
G
E
V
Y
E
G
Q
-
V
-----------------
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
----
P
------
S
--------
Q
--
P
S
---------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
-------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Blastp_CBE
91.52
99%
-127
- C2 -
-
5AAC
7.3
-
A:
[9-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
G
H
---
G
E
V
Y
E
G
Q
-
V
-----------------
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
Y
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
----
P
------
S
--------
Q
--
P
S
---------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
-------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Blastp_CBE
91.45
99%
-127
- C2 -
-
5A9U
7.6
-
A:
[9-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
G
H
---
G
E
V
Y
E
G
Q
-
V
-----------------
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
Y
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
----
P
------
S
--------
Q
--
P
S
---------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
-------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Blastp_CBE
91.43
99%
-130
- C2 -
-
4CLI
7.6
-
A:
[9-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
-----------------
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
----
P
------
S
--------
Q
--
P
S
---------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
-------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
Blastp_CBE
91.34
99%
-132
- C2 -
-
4CD0
7.7
-
A:
[25-332]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
---------------
S
-
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
----
P
------
S
--------
Q
--
P
S
---------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
-------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
572
HHSearch
91.33
100%
-129
- C2 -
-
4Z55
9.6
-
A:
[22-328]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
---------------
S
-
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
----
P
-------------------------------------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
A
G
Y
Y
--
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Blastp_CBE
91.30
99%
-128
- C2 -
-
4CLJ
7.4
-
A:
[10-317]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
---------------
S
-
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
----
P
------
S
--------
Q
--
P
S
---------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
-------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Blastp_CBE
91.29
99%
-131
- C2 -
-
5AAB
6.9
-
A:
[9-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
G
H
G
--
G
E
V
Y
E
G
Q
-
V
-----------------
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
Y
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
F
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
----
P
------
S
--------
Q
--
P
S
---------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
-------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Blastp_CBE
91.27
99%
-125
- C2 -
-
5KZ0
6.7
-
A:
[9-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
-----------------
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
----
P
------
S
--------
Q
--
P
S
---------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
---------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
91.12
99%
-129
- C2 -
-
4Z55
9.6
-
A:
[22-328]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
---------------
S
-
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
----
P
-------------------------------------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
A
G
Y
Y
--
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Blastp_CBE
90.68
99%
-130
- C2 -
-
4CCU
7.6
-
A:
[9-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
G
H
---
G
E
V
Y
E
G
Q
-
V
-----------------
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
----
P
------
S
--------
Q
--
P
S
---------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
-------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
90.63
99%
-125
- C2 -
-
4FOC
8.2
-
A:
[36-345]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
S
F
A
G
K
T
S
S
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
---
S
-----------
S
-
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
----
P
------
S
--------
Q
--
P
S
---------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
---------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
Y
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Blastp_CBE
90.23
100%
-127
- C2 -
-
2XB7
8.3
-
A:
[3-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
---------------
S
-
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
----
P
------
S
--------
Q
--
P
S
---------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
------------------
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
90.08
99%
-124
- C2 -
-
4DCE
9.6
-
ALK_HUMAN
A:
[16-325]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
S
F
A
G
K
T
S
S
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
G
H
---
G
E
V
Y
E
G
Q
-
V
---
S
--------
P
--
S
-
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
----
P
------
S
--------
Q
--
P
S
---------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
------------------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
Y
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
89.58
99%
-123
- C2 -
-
4FNZ
10.1
-
A:
[10-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
S
F
A
G
K
T
S
S
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
G
H
---
G
E
V
Y
E
G
Q
-
V
---
S
G
----------
S
-
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
----
P
------
S
--------
Q
--
P
S
---------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
-------------------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
Y
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Blastp_CBE
89.45
99%
-132
- C2 -
-
4CNH
6.1
-
ALK_HUMAN
A:
[10-317]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
------
E
V
Y
E
G
Q
-
V
---------------
S
-
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
----
P
------
S
--------
Q
--
P
S
---------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
-----------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Blastp_CBE
89.40
99%
-129
- C2 -
-
4DCE
10.1
-
B:
[17-325]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
S
F
A
G
K
T
S
S
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
G
H
----
E
V
Y
E
G
Q
-
V
---
S
-----------
S
-
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
----
P
------
S
--------
Q
--
P
S
---------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
-------------------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
Y
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Blastp_CBE
89.33
100%
-129
- C2 -
-
5FTQ
10.0
-
A:
[2-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
---------------
S
-
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
----
P
------
S
--------
Q
--
P
S
---------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
---------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
-
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
89.30
99%
-131
- C2 -
-
4CCB
7.0
-
A:
[9-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
-----------------
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
-----------------------
P
S
---------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
-----------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Blastp_CBE
89.10
99%
-131
- C2 -
-
4CMT
7.2
-
A:
[9-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
G
H
---
G
E
V
Y
E
G
Q
-
V
-----------------
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
-----------------------
P
S
---------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
-----------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
88.97
99%
-132
- C2 -
-
2XP2
7.3
-
A:
[9-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
--
G
A
F
G
E
V
Y
E
G
Q
-
V
-----------------
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
-----------------------
P
S
---------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
-----------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Blastp_CBE
88.93
99%
-130
- C2 -
-
4CNH
5.3
-
B:
[9-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
---------------
S
-
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
-----------------------
P
S
---------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
A
S
Y
------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Blastp_CBE
88.67
99%
-126
- C2 -
-
4TT7
2.6
-
A:
[2-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
G
----
G
E
V
Y
E
G
Q
-
V
---
S
-------------
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
-----------------------
P
S
---------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
A
S
--
R
-
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
Blastp_CBE
88.52
100%
-128
- C2 -
-
6E0R
7.5
-
A:
[15-315]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
K
T
S
S
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
G
H
G
----
V
Y
E
G
Q
-
V
---------------
S
-
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
----
P
------
S
--------
Q
--
P
S
---------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
------------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Blastp_CBE
88.12
100%
-130
- C2 -
-
6EDL
7.0
-
A:
[9-315]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
G
H
---
G
E
V
Y
E
G
Q
-
V
---
S
-----------
S
-
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
----
P
------
S
--------
Q
--
P
S
---------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
--------------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
88.00
99%
-125
- C2 -
-
4FOB
9.1
-
A:
[36-345]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
S
F
A
G
K
T
S
S
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
---
S
-----------
S
-
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
-----------------------
P
S
---------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
A
-------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
Y
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
575
HHSearch
87.93
100%
-134
- C2 -
-
5FTO
9.8
-
A:
[13-303]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
---
S
G
M
---------
S
-
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
----
P
------
S
--------
Q
--
P
S
---------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
--------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Blastp_CBE
87.82
100%
-135
- C2 -
-
2XBA
7.4
-
A:
[3-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
-------
V
Y
E
G
Q
-
V
---------------
S
-
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
----
P
------
S
--------
Q
--
P
S
---------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
-----------
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
87.71
99%
-132
- C2 -
-
5IUH
10.0
-
A:
[10-321]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
S
F
A
G
K
T
S
S
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
-----
G
E
V
Y
E
G
Q
-
V
---
S
G
------------
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
-----------------------
P
S
---------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
-----------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
Y
G
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
Blastp_CBE
87.55
100%
-135
- C2 -
-
6EBW
7.8
-
A:
[12-315]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
C
F
---
T
S
S
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
G
H
--
F
G
E
V
Y
E
G
Q
-
V
---
S
-----------
S
-
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
----
P
------------------
P
S
---------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
---
D
---------------
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
576
HHSearch
87.54
100%
-137
- C2 -
-
4FNW
2.8
-
A:
[22-311]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
G
----
G
E
V
Y
E
G
Q
-
V
---
S
-----------
S
-
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
L
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
----
P
------
S
--------
Q
--
P
S
---------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
---------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
87.18
99%
-127
- C2 -
-
5IUG
10.4
-
A:
[10-321]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
S
F
A
G
K
T
S
S
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
G
----
G
E
V
Y
E
G
Q
-
V
---
S
-------------
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
----
P
-----------------------------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
----------------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
Y
G
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
Blastp_CBE
87.16
100%
-133
- C2 -
-
6MX8
7.9
-
A:
[1-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
G
H
---
G
E
V
Y
E
G
Q
-
V
---------------
S
-
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
----
P
------------------
P
S
---------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
-----------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
574
HHSearch
85.78
100%
-133
- C2 -
-
5FTQ
10.0
-
A:
[11-303]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
---------------
S
-
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
----
P
------
S
--------
Q
--
P
S
---------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
---------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
-
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
84.49
99%
-129
- C2 -
-
4FNY
10.4
-
A:
[20-321]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
I
S
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
G
H
---
G
E
V
Y
E
G
Q
-
V
---
S
G
------------
P
L
-
Q
---
V
A
V
K
T
L
--
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
----
P
-----------------------------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
--------------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
Y
G
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Blastp_CBE
79.61
99%
-126
- C2 -
-
5IMX
8.5
-
A:
[25-316]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
---------------
S
-
P
L
-
Q
---
V
A
V
K
T
L
------------
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
----
P
------
S
--------
Q
--
P
S
---------
S
-------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
-----------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
75.97
99%
-141
- C2 -
-
4JOA
8.0
-
A:
[41-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
-
K
-
E
V
P
R
K
N
I
T
L
I
R
G
--
L
G
------
V
Y
E
G
Q
-
V
---
S
--------------
L
-
Q
---
V
A
V
K
T
L
--
P
----------
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
H
-
Q
N
I
V
R
----
C
I
G
V
-
S
L
Q
S
-
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
------
E
T
R
----
P
-------
R
------------------------------------------
L
A
---
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
P
G
--
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
-----------
A
M
L
P
V
K
W
M
P
P
E
A
---
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
-
K
-
S
-
N
Q
E
-
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
----
T
Q
D
-
P
D
V
I
N
T
A
L
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
145
Blastp_CBE
73.84
41%
-132
- C2 -
-
6D20
5.7
-
A:
[11-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
Q
Y
F
------
S
D
A
C
V
-
H
-
H
I
K
R
R
D
I
V
L
K
W
E
--
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
---
H
N
L
L
-
P
E
--
Q
--
D
-
K
M
-
L
---
V
A
V
K
A
L
--
K
-
E
-
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
-
Q
H
I
V
R
----
F
F
G
V
-
C
T
E
G
-
R
P
L
------
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
------
S
H
G
----
P
-------
D
----
A
-------------------
G
---------
P
-------
L
G
---
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
F
G
M
S
R
---
D
I
Y
S
T
D
Y
Y
R
-
V
G
--
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
-
L
-
S
-
N
T
E
-
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
L
Q
A
L
----
A
Q
A
-
P
P
V
Y
L
D
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
146
Blastp_CBE
72.06
41%
-130
- C2 -
-
6D1Z
2.5
-
A:
[9-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
Q
Y
F
------
S
D
A
C
V
-
H
-
H
I
K
R
R
D
I
V
L
K
W
E
--
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
---
H
N
L
L
-
P
E
--
Q
--
D
-
K
M
-
L
---
V
A
V
K
A
L
--
K
-
E
-
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
-
Q
H
I
V
R
----
F
F
G
V
-
C
T
E
G
-
R
P
L
------
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
------
S
H
G
----
P
-------
D
------------------------
G
---------
P
-------
L
G
---
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
F
G
M
S
R
---
D
I
Y
S
T
D
Y
Y
-----
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
-
L
-
S
-
N
T
E
-
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
L
Q
A
L
----
A
Q
A
-
P
P
V
Y
L
D
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
142
Blastp_CBE
70.29
41%
-135
- C2 -
-
6DKI
9.0
-
A:
[24-319]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
C
V
-
H
-
H
I
K
R
R
D
I
V
L
K
W
E
--
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
---
H
N
L
L
-
P
E
--
Q
--
D
-
K
M
-
L
---
V
A
V
K
A
L
--
K
-
E
-
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
-
Q
H
I
V
R
----
F
F
G
V
-
C
T
E
G
-
R
P
L
------
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
------
S
H
G
----
P
-------
D
------------------------
G
---------
P
-------
L
G
---
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
F
G
--
R
---
D
I
Y
S
T
D
Y
Y
-----
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
-
L
-
S
-
N
T
E
-
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
L
Q
A
L
----
A
Q
A
-
P
P
V
Y
L
D
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
143
Blastp_CBE
70.04
41%
-139
- C2 -
-
6DKG
8.4
-
A:
[24-319]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
C
V
-
H
-
H
I
K
R
R
D
I
V
L
K
W
E
--
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
---
H
N
L
L
-
P
E
--
Q
--
D
-
K
M
-
L
---
V
A
V
K
A
L
--
K
-
E
-
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
-
Q
H
I
V
R
----
F
F
G
V
-
C
T
E
G
-
R
P
L
------
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
------
S
H
G
----
P
-------
D
------------------------
G
---------
P
-------
L
G
---
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
F
G
--------
Y
S
T
D
Y
Y
-----
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
-
L
-
S
-
N
T
E
-
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
L
Q
A
L
----
A
Q
A
-
P
P
V
Y
L
D
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
153
Blastp_CBE
69.48
41%
-80
- C2 -
-
5KMK
5.1
-
A:
[14-322]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
Q
Y
F
------
S
D
A
C
V
-
H
-
H
I
K
R
R
D
I
V
L
K
W
E
--
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
---
H
N
L
L
-
P
E
--
Q
--
D
-
K
M
-
L
---
V
A
V
K
A
L
--
K
-----
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
-
Q
H
I
V
R
----
F
F
G
V
-
C
T
E
G
-
R
P
L
------
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
------
S
H
G
----
P
-------
D
----
A
------
K
LGGEDV--
A
--
P
G
---------
P
-------
L
G
---
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
F
G
M
S
R
---
D
I
Y
S
T
D
Y
Y
R
-
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
-
L
-
S
-
N
T
E
-
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
L
Q
A
L
----
A
Q
A
-
P
P
V
Y
L
D
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
147
Blastp_CBE
68.91
41%
-88
- C2 -
-
6D1Y
4.1
-
A:
[17-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
Q
Y
F
------
S
D
A
C
V
-
H
-
H
I
K
R
R
D
I
V
L
K
W
E
--
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
---
H
N
L
L
--------
D
-
K
M
-
L
---
V
A
V
K
A
L
--
K
-
E
-
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
-
Q
H
I
V
R
----
F
F
G
V
-
C
T
E
G
-
R
P
L
------
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
------
S
H
G
----
P
-------
D
----
A
------
K
L-----------
G
---------
P
-------
L
G
---
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
F
G
M
S
R
---
D
I
Y
S
T
D
Y
Y
-----
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
-
L
-
S
-
N
T
E
-
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
L
Q
A
L
----
A
Q
A
-
P
P
V
Y
L
D
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
144
Blastp_CBE
68.82
41%
-142
- C2 -
-
6DKB
8.8
-
A:
[25-319]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
V
-
H
-
H
I
K
R
R
D
I
V
L
K
W
E
--
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
---
H
N
L
L
-
P
E
--
Q
--
D
-
K
M
-
L
---
V
A
V
K
A
L
--
K
-
E
-
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
-
Q
H
I
V
R
----
F
F
G
V
-
C
T
E
G
-
R
P
L
------
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
------
S
H
G
------------------------------------
P
G
---------
P
-------
L
G
---
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
F
G
---------
S
T
D
Y
Y
R
------
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
-
L
-
S
-
N
T
E
-
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
L
Q
A
L
----
A
Q
A
-
P
P
V
Y
L
D
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
589
HHSearch
68.78
45%
-126
- C2 -
-
1K3A
4.5
-
A:
[6-285]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
E
--
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
---
K
G
V
V
-
K
D
--
E
--
P
-
E
T
-
R
---
V
A
I
K
T
V
--
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
-
H
H
V
V
R
----
L
L
G
V
-
V
S
Q
G
-
Q
P
T
------
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
------
S
L
R
----
P
-------
E
----
M
-------------------------------------
P
S
---
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
-----
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
E
T
D
Y
Y
R
-
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
A
E
Q
P
Y
Q
G
-
L
-
S
-
N
E
Q
-
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
L
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
E
E
----
M
E
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
138
Blastp_CBE
68.64
41%
-141
- C2 -
-
4AOJ
7.5
-
C:
[33-322]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
C
V
-
H
-
H
I
K
R
R
D
I
V
L
K
W
E
--
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
---
H
N
L
L
-
P
---
Q
--
D
-
K
M
-
L
---
V
A
V
K
A
L
--
K
-
E
-
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
-
Q
H
I
V
R
----
F
F
G
V
-
C
T
E
G
-
R
P
L
------
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
------
S
H
G
----
P
-------
D
------------------------
G
---------
P
-------
L
G
---
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
F
G
M
--------------------
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
-
L
-
S
-
N
T
E
-
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
L
Q
A
L
----
A
Q
A
-
P
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
151
Blastp_CBE
68.55
41%
-79
- C2 -
-
5KMM
4.3
-
A:
[12-322]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
Q
Y
F
------
S
D
A
C
V
-
H
-
H
I
K
R
R
D
I
V
L
K
W
E
--
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
---
H
N
L
L
-
P
E
--
Q
--
D
-
K
M
-
L
---
V
A
V
K
A
L
--
K
-----
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
-
Q
H
I
V
R
----
F
F
G
V
-
C
T
E
G
-
R
P
L
------
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
------
S
H
G
----
P
-------
D
----
A
------
K
LGGEDV--
A
--
P
G
---------
P
-------
L
G
---
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
F
G
M
S
R
---
D
I
Y
S
T
D
Y
Y
R
-
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
-
L
-
S
-
N
T
E
-
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
L
Q
A
L
----
A
Q
A
-
P
P
V
Y
L
D
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
156
Blastp_CBE
68.25
41%
-144
- C2 -
-
6DKW
9.2
-
B:
[14-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
H
-
H
I
K
R
R
D
I
V
L
K
W
E
--
L
G
E
---
G
K
V
F
L
A
E
-
C
---
H
N
L
L
-
P
E
--
Q
--
D
-
K
M
-
L
---
V
A
V
K
A
L
--
K
-
E
-
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
-
Q
H
I
V
R
----
F
F
G
V
-
C
T
E
G
-
R
P
L
------
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
------
S
H
G
----
P
-------
D
----
A
------
K
------------
G
---------
P
-------
L
G
---
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
F
G
--------------------
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
-
L
-
S
-
N
T
E
-
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
L
Q
A
L
----
A
Q
A
-
P
P
V
Y
L
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
150
Blastp_CBE
67.48
41%
-68
- C2 -
-
5KMN
4.1
-
A:
[2-323]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
Q
Y
F
------
S
D
A
C
V
-
H
-
H
I
K
R
R
D
I
V
L
K
W
E
--
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
---
H
N
L
L
-
P
------
D
-
K
M
-
L
---
V
A
V
K
A
L
--
K
-
E
--
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
-
Q
H
I
V
R
----
F
F
G
V
-
C
T
E
G
-
R
P
L
------
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
------
S
H
G
----
P
-------
D
----
A
-------GEDV----
A
--
P
G
---------
P
-------
L
G
---
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
F
G
M
S
R
---
D
I
Y
S
T
D
Y
Y
R
-
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
-
L
-
S
-
N
T
E
-
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
L
Q
A
L
----
A
Q
A
-
P
P
V
Y
L
D
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
154
Blastp_CBE
67.21
41%
-66
- C2 -
-
5KMJ
5.9
-
A:
[20-322]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
Q
----------
A
C
V
-
H
-
H
I
K
R
R
D
I
V
L
K
W
E
--
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
---
H
N
L
L
-
P
E
--
Q
--
D
-
K
M
-
L
---
V
A
V
K
A
L
--
K
-
E
---
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
-
Q
H
I
V
R
----
F
F
G
V
-
C
T
E
G
-
R
P
L
------
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
------
S
H
G
----
P
-------
D
----
A
------
K
GEDV----
A
--
P
G
---------
P
-------
L
G
---
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
F
G
M
S
R
---
D
I
Y
S
T
D
Y
Y
R
-
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
-
L
-
S
-
N
T
E
-
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
L
Q
A
L
----
A
Q
A
-
P
P
V
Y
L
D
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
140
Blastp_CBE
67.18
41%
-146
- C2 -
-
4AOJ
7.6
-
NTRK1_HUMAN
A:
[33-322]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
C
V
-
H
-
H
I
K
R
R
D
I
V
L
K
W
E
--
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
---
H
N
L
L
-
P
--------
K
M
-
L
---
V
A
V
K
A
L
--
K
-
E
-
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
-
Q
H
I
V
R
----
F
F
G
V
-
C
T
E
G
-
R
P
L
------
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
------
S
H
G
----
P
-------
D
-----------------------
P
G
---------
P
-------
L
G
---
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
F
G
--------------------
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
-
L
-
S
-
N
T
E
-
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
L
Q
A
L
----
A
Q
A
-
P
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
152
Blastp_CBE
67.07
41%
-68
- C2 -
-
5KML
3.8
-
A:
[2-323]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
Q
Y
F
------
S
D
A
C
V
-
H
-
H
I
K
R
R
D
I
V
L
K
W
E
--
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
---
H
N
L
L
-
P
------
D
-
K
M
-
L
---
V
A
V
K
A
L
--
K
-
E
--
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
-
Q
H
I
V
R
----
F
F
G
V
-
C
T
E
G
-
R
P
L
------
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
------
S
H
G
----
P
-------
D
----
A
-------GEDV----
A
--
P
G
---------
P
-------
L
G
---
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
F
G
M
S
R
---
D
I
Y
S
T
D
Y
Y
R
-
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
-
L
-
S
-
N
T
E
-
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
L
Q
A
L
----
A
Q
A
-
P
P
V
Y
L
D
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
139
Blastp_CBE
66.65
41%
-140
- C2 -
-
4AOJ
6.8
-
NTRK1_HUMAN
B:
[33-324]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
C
V
-
H
-
H
I
K
R
R
D
I
V
L
K
W
E
--
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
---
H
N
L
L
-
P
--------
K
M
-
L
---
V
A
V
K
A
L
--
K
-
E
-
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
-
Q
H
I
V
R
----
F
F
G
V
-
C
T
E
G
-
R
P
L
------
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
------
S
H
G
----
P
-------
D
------------------------
G
---------
P
-------
L
G
---
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
F
-----------------------
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
-
L
-
S
-
N
T
E
-
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
L
Q
A
L
----
A
Q
A
-
P
P
V
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
162
Blastp_CBE
66.62
41%
-78
- C2 -
-
6PL3
6.3
-
A:
[16-311]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
C
V
-
H
-
H
I
K
R
R
D
I
V
L
K
W
E
--
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
---
H
N
L
L
-
P
E
--
Q
--
D
-
K
M
-
L
---
V
A
V
K
A
L
--
K
-
E
--
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
-
Q
H
I
V
R
----
F
F
G
V
-
C
T
E
G
-
R
P
L
------
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
------
S
H
G
----
P
-------
D
------------AGGEDV--
A
--
P
G
---------
P
-------
L
G
---
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
F
G
M
S
R
---
D
I
Y
S
T
D
Y
Y
R
-
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
-
L
-
S
-
N
T
E
-
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
L
Q
A
L
----
A
Q
A
-
P
P
V
Y
L
D
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
586
HHSearch
66.52
44%
-125
- C2 -
-
3CBL
8.3
-
A:
[110-374]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
N
H
E
D
L
V
L
G
E
Q
--
I
G
R
G
N
F
G
E
V
F
S
G
R
-
L
---
R
--------
A
--
D
-
N
T
-
L
---
V
A
V
K
S
C
--
R
-
E
T
L
P
P
D
L
K
A
K
-
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
H
-
P
N
I
V
R
----
L
I
G
V
-
C
T
Q
K
-
Q
P
I
------
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
------
T
E
G
-------------------------------------
A
---------
R
-------
L
R
---
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
-----
N
V
L
K
I
S
D
F
G
M
S
R
---
E
E
A
D
G
V
Y
A
A
-
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
-
L
G
A
S
P
Y
P
N
-
L
-
S
-
N
Q
Q
-
T
R
E
F
V
E
K
-------
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
---
E
L
Q
S
I
----
R
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
434
Blastp_CBE
66.50
39%
-131
- C2 -
-
4TWP
7.7
-
ABL1_HUMAN
B:
[1-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--
K
-
E
D
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
584
HHSearch
66.47
44%
-125
- C2 -
-
3BKB
8.4
-
A:
[110-374]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
N
H
E
D
L
V
L
G
E
Q
--
I
G
R
G
N
F
G
E
V
F
S
G
R
-
L
---
R
--------
A
--
D
-
N
T
-
L
---
V
A
V
K
S
C
--
R
-
E
T
L
P
P
D
L
K
A
K
-
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
H
-
P
N
I
V
R
----
L
I
G
V
-
C
T
Q
K
-
Q
P
I
------
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
------
T
E
G
-------------------------------------
A
---------
R
-------
L
R
---
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
-----
N
V
L
K
I
S
D
F
G
M
S
R
---
E
E
A
D
G
V
Y
A
A
-
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
-
L
G
A
S
P
Y
P
N
-
L
-
S
-
N
Q
Q
-
T
R
E
F
V
E
K
-------
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
---
E
L
Q
S
I
----
R
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
583
HHSearch
66.46
44%
-128
- C2 -
-
6JMF
6.8
-
A:
[108-372]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
N
H
E
D
L
V
L
G
E
Q
--
I
G
R
G
N
F
G
E
V
F
S
G
R
-
L
---
R
--------
A
--
D
-
N
T
-
L
---
V
A
V
K
S
C
--
R
-
E
T
L
P
P
D
L
K
A
K
-
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
H
-
P
N
I
V
R
----
L
I
G
V
-
C
T
Q
K
-
Q
P
I
------
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
------
T
E
G
-------------------------------------
A
---------
R
-------
L
R
---
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
-----
N
V
L
K
I
S
D
F
G
M
S
R
---
E
E
A
D
G
V
Y
A
A
-
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
-
L
G
A
S
P
Y
P
N
-
L
-
S
-
N
Q
Q
-
T
R
E
F
V
E
K
-------
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
---
E
L
Q
S
I
----
R
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
Blastp_CBE
66.40
44%
-59
- C2 -
-
5FXS
7.3
-
A:
[3-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
A
A
D
V
Y
V
P
D
E
-
W
-
E
V
A
R
E
K
I
T
M
S
R
E
--
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
---
K
G
V
V
-
K
D
--
E
--
P
-
E
T
-
R
---
V
A
I
K
T
V
--
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
-
H
H
V
V
R
----
L
L
G
V
-
V
S
Q
G
-
Q
P
T
------
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
------
S
L
R
----
P
-------
E
----
M
------
E
--------
N
--
N
P
---------
V
-------
L
A
PPS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
---
A
I
Y
E
T
D
Y
Y
R
-
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
A
E
E
P
Y
Q
G
-
L
-
S
-
N
E
Q
-
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
149
Blastp_CBE
66.24
41%
-77
- C2 -
-
5KMO
6.1
-
A:
[27-322]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
C
V
-
H
-
H
I
K
R
R
D
I
V
L
K
W
E
--
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
---
H
N
L
L
-
P
E
--
Q
--
D
-
K
M
-
L
---
V
A
V
K
A
L
--
K
-----
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
-
Q
H
I
V
R
----
F
F
G
V
-
C
T
E
G
-
R
P
L
------
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
------
S
H
G
----
P
-------
D
----
A
------
K
LGGEDV--
A
--
P
G
---------
P
-------
L
G
---
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
F
G
--
R
---
D
I
Y
S
T
D
Y
Y
R
-
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
-
L
-
S
-
N
T
E
-
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
L
Q
A
L
----
A
Q
A
-
P
P
V
Y
L
D
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
490
Blastp_CBE
66.11
39%
-124
- C2 -
-
3CS9
8.0
-
ABL1_HUMAN
D:
[10-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
--------------------
T
---
V
A
V
K
T
L
--
K
-
E
D
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
373
Blastp_CBE
65.99
39%
-127
- C2 -
-
2Z60
8.4
-
ABL1_MOUSE
A:
[6-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--
K
-
E
---
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
S
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
Blastp_CBE
65.80
44%
-40
- C2 -
-
3ETA
11.9
-
INSR_HUMAN
A:
[12-305]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
E
--
L
G
Q
G
S
F
G
M
V
Y
E
G
N
-
A
---
R
D
I
I
-
K
G
--
E
--
A
-
E
T
-
R
---
V
A
V
K
T
V
--
N
-
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
C
-
H
H
V
V
R
----
L
L
G
V
-
V
S
K
G
-
Q
P
T
------
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
------
S
L
R
----
P
-------
E
AENN
P
------
G
--------
R
--
P
P
---------
P
--------
T
---
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
H
D
--
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
E
T
D
Y
Y
R
-
K
-
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
-
L
A
E
Q
P
Y
Q
G
-
L
-
S
-
N
E
Q
-
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
---
L
L
K
-----------
D
D
L
H
P
S
F
P
-
E
V
S
F
F
H
S
E
E
N
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
520
Blastp_CBE
65.52
39%
-124
- C2 -
-
4XEY
5.6
-
ABL1_HUMAN
A:
[118-387]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
----
G
E
V
Y
E
G
V
-
W
---
K
K
Y
S
-----------
L
-
T
---
V
A
V
K
T
L
--
K
-
E
D
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
Blastp_CBE
65.51
45%
-67
- C2 -
-
5FXR
6.9
-
A:
[2-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
A
A
D
V
Y
V
P
D
E
-
W
-
E
V
A
R
E
K
I
T
M
S
R
E
--
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
---
K
G
V
V
-
K
D
--
E
--
P
-
E
T
-
R
---
V
A
I
K
T
V
----
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
-
H
H
V
V
R
----
L
L
G
V
-
V
S
Q
G
-
Q
P
T
------
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
------
S
L
R
----
P
-------
E
----
M
------
E
--------
N
--
N
P
---------
V
-------
L
A
PPS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
E
T
D
Y
Y
R
----
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
A
E
Q
P
Y
Q
G
-
L
-
S
-
N
E
Q
-
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
168
Blastp_CBE
65.36
41%
-50
- C2 -
-
6PL2
8.2
-
A:
[15-311]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
C
V
-
H
-
H
I
K
R
R
D
I
V
L
K
W
E
--
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
---
H
N
L
L
-
P
E
--
Q
--
D
-
K
M
-
L
---
V
A
V
K
A
L
--
K
-
E
-
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
-
Q
H
I
V
R
----
F
F
G
V
-
C
T
E
G
-
R
P
L
------
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
------
S
H
G
----
P
-------
D
----
A
------
K
LLAGGEDV
A
--
P
G
---------
P
-------
L
G
---
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
F
G
M
S
R
---
D
I
Y
S
T
D
Y
Y
R
-
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
-
L
-
S
-
N
T
E
-
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
L
Q
A
L
----
A
Q
A
-
P
P
V
Y
L
D
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
155
Blastp_CBE
64.98
41%
-62
- C2 -
-
5KMI
6.2
-
A:
[20-322]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
Q
-----------
C
V
-
H
-
H
I
K
R
R
D
I
V
L
K
W
E
--
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
---
H
N
L
L
-
P
E
--
Q
--
D
-
K
M
-
L
---
V
A
V
K
A
L
--
K
-----
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
-
Q
H
I
V
R
----
F
F
G
V
-
C
T
E
G
-
R
P
L
------
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
------
S
H
G
----
P
-------
D
----
A
------
K
LGEDV---
A
--
P
G
---------
P
-------
L
G
---
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
F
G
M
S
R
---
D
I
Y
S
T
D
Y
Y
R
-
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
-
L
-
S
-
N
T
E
-
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
L
Q
A
L
----
A
Q
A
-
P
P
V
Y
L
D
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
171
Blastp_CBE
64.97
41%
-66
- C2 -
-
6NPT
5.8
-
A:
[1-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
A
C
V
-
H
-
H
I
K
R
R
D
I
V
L
K
W
E
--
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
---
H
N
L
L
-
P
E
--
Q
--
D
-
K
M
-
L
---
V
A
V
K
A
L
--
K
-
E
-----
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
-
Q
H
I
V
R
----
F
F
G
V
-
C
T
E
G
-
R
P
L
------
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
------
S
H
G
----
P
--------------------GGEDV---
A
--
P
G
---------
P
-------
L
G
---
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
F
G
M
S
R
---
D
I
Y
S
T
D
Y
Y
R
-
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
-
L
-
S
-
N
T
E
-
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
L
Q
A
L
----
A
Q
A
-
P
P
V
Y
L
D
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
410
Blastp_CBE
64.93
39%
-125
- C2 -
-
2QOH
8.5
-
ABL1_MOUSE
B:
[6-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--
K
----
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
S
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
408
Blastp_CBE
64.85
39%
-129
- C2 -
-
3KF4
8.2
-
ABL1_MOUSE
B:
[6-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
------
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
S
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
469
Blastp_CBE
64.79
39%
-125
- C2 -
-
2G2H
9.5
-
ABL1_HUMAN
B:
[8-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
K
Y
S
-----------
L
-
T
---
V
A
V
K
T
L
--
K
-
E
D
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
P
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
163
Blastp_CBE
64.78
41%
-51
- C2 -
-
6NSS
6.7
-
A:
[9-311]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
Q
-----------
C
V
-
H
-
H
I
K
R
R
D
I
V
L
K
W
E
--
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
---
H
N
L
L
-
P
E
--
Q
--
D
-
K
M
-
L
---
V
A
V
K
A
L
--
K
-----
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
-
Q
H
I
V
R
----
F
F
G
V
-
C
T
E
G
-
R
P
L
------
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
------
S
H
G
----
P
-------
D
----
A
------
K
LLAGGEDV
A
--
P
G
---------
P
-------
L
G
---
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
F
G
M
S
R
---
D
I
Y
S
T
D
Y
Y
R
-
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
-
L
-
S
-
N
T
E
-
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
L
Q
A
L
----
A
Q
A
-
P
P
V
Y
L
D
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
Blastp_CBE
64.76
46%
-63
- C2 -
-
3NW7
8.5
-
A:
[9-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
D
E
-
W
-
E
V
A
R
E
K
I
T
M
S
R
E
--
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
---
K
G
V
V
-
K
D
--
E
--
P
-
E
T
-
R
---
V
A
I
K
T
V
--
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
-
H
H
V
V
R
----
L
L
G
V
-
V
S
Q
G
-
Q
P
T
------
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
------
S
L
R
----
P
-------
E
----
M
------
E
--------
N
--
N
P
---------
V
-------
L
A
PPS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
E
T
D
Y
Y
R
----
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
A
E
Q
P
Y
Q
G
-
L
-
S
-
N
E
Q
-
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
148
Blastp_CBE
64.71
41%
-46
- C2 -
-
5H3Q
7.3
-
A:
[21-323]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
Q
Y
F
------
S
D
A
C
V
-
H
-
H
I
K
R
R
D
I
V
L
K
W
E
--
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
---
H
N
------------
K
M
-
L
---
V
A
V
K
A
L
--
K
-
E
-----
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
-
Q
H
I
V
R
----
F
F
G
V
-
C
T
E
G
-
R
P
L
------
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
------
S
H
G
----
P
-------
D
----
A
------
K
LLAGGEDV
A
--
P
G
---------
P
-------
L
G
---
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
F
G
M
S
R
---
D
I
Y
S
T
D
Y
Y
R
-
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
-
L
-
S
-
N
T
E
-
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
L
Q
A
L
----
A
Q
A
-
P
P
V
Y
L
D
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
421
Blastp_CBE
64.60
39%
-124
- C2 -
-
3MS9
10.9
-
ABL1_MOUSE
B:
[11-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
------
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
S
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
141
Blastp_CBE
64.57
41%
-80
- C2 -
-
6NSP
6.8
-
A:
[3-296]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
H
-
H
I
K
R
R
D
I
V
L
K
W
E
--
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
---
H
N
L
L
-
P
E
--
Q
--
D
-
K
M
-
L
---
V
A
V
K
A
L
--
K
-
E
-
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
-
Q
H
I
V
R
----
F
F
G
V
-
C
T
E
G
-
R
P
L
------
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
------
S
H
G
----
P
-------
D
----
A
-------AGGEDV--
A
--
P
G
---------
P
-------
L
G
---
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
F
G
M
S
R
---
D
I
Y
S
T
D
Y
Y
R
-
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
-
L
-
S
-
N
T
E
-
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
L
Q
A
L
----
A
Q
A
-
P
P
V
Y
L
D
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
435
Blastp_CBE
64.48
39%
-131
- C2 -
-
4TWP
7.4
-
ABL1_HUMAN
A:
[1-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--------
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
494
Blastp_CBE
64.44
39%
-135
- C2 -
-
2HZI
10.2
-
ABL1_HUMAN
B:
[10-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
K
Y
S
-----------
L
-
T
---
V
A
V
K
T
L
-------
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
186
Blastp_CBE
64.40
43%
-122
- C2 -
-
3CBL
8.3
-
A:
[114-370]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
L
V
L
G
E
Q
--
I
G
R
G
N
F
G
E
V
F
S
G
R
-
L
---
R
A
----------
D
-
N
T
-
L
---
V
A
V
K
S
C
--
R
-
E
T
L
P
P
D
L
K
A
K
-
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
H
-
P
N
I
V
R
----
L
I
G
V
-
C
T
Q
K
-
Q
P
I
------
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
---------------------------------
T
--------
E
--
G
A
---------
R
-------
L
R
---
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
---
E
K
--
N
V
L
K
I
S
D
F
G
M
S
R
---
E
E
A
D
G
V
Y
A
A
-
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
-
L
G
A
S
P
Y
P
N
-
L
-
S
-
N
Q
Q
-
T
R
E
F
V
E
K
-------
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
---
E
L
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
444
Blastp_CBE
64.39
39%
-128
- C2 -
-
3UE4
7.2
-
ABL1_HUMAN
B:
[8-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
--
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--
K
-
E
D
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
Blastp_CBE
64.34
45%
-68
- C2 -
-
1JQH
4.1
-
IGF1R_HUMAN
B:
[6-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
V
Y
V
P
D
E
-
W
-
E
V
A
R
E
K
I
T
M
S
R
E
--
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
---
K
G
V
V
-
K
D
--
E
--
P
-
E
T
-
R
---
V
A
I
K
T
V
--
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
-
H
H
V
V
R
----
L
L
G
V
-
V
S
Q
G
-
Q
P
T
------
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
------
S
L
R
----
P
----------------------------------------------------PPS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
--
F
T
V
K
I
G
D
F
G
M
T
----------
Y
Y
R
-
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
A
E
Q
P
Y
Q
G
-
L
-
S
-
N
E
Q
-
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
Blastp_CBE
64.32
45%
-67
- C2 -
-
1JQH
4.6
-
IGF1R_HUMAN
A:
[6-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
V
Y
V
P
D
E
-
W
-
E
V
A
R
E
K
I
T
M
S
R
E
--
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
---
K
G
V
V
-
K
D
--
E
--
P
-
E
T
-
R
---
V
A
I
K
T
V
--
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
-
H
H
V
V
R
----
L
L
G
V
-
V
S
Q
G
-
Q
P
T
------
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
------
S
L
R
----
P
-------
E
----------------------------------
V
-------
L
A
PPS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
--
F
T
V
K
I
G
D
F
G
M
T
----------
Y
Y
R
-
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
A
E
Q
P
Y
Q
G
-
L
-
S
-
N
E
Q
-
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
428
Blastp_CBE
64.19
39%
-123
- C2 -
-
1M52
9.6
-
ABL1_MOUSE
B:
[11-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--
K
-
E
D
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
S
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
Blastp_CBE
64.11
44%
-44
- C2 -
-
3ETA
12.0
-
B:
[12-305]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
E
--
L
G
Q
G
S
F
G
M
V
Y
E
G
N
-
A
---
R
D
I
I
-
K
G
--
E
--
A
-
E
T
-
R
---
V
A
V
K
T
V
--
N
-
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
C
-
H
H
V
V
R
----
L
L
G
V
-
V
S
K
G
-
Q
P
T
------
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
------
S
L
R
----
P
-------
E
AENN
P
------
G
--------
R
--
P
P
---------
P
--------
T
---
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
H
D
--
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
E
T
D
Y
Y
R
-
K
--
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
-
L
A
E
Q
P
Y
Q
G
-
L
-
S
-
N
E
Q
-
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
---
L
L
K
-----------
D
D
L
H
P
S
F
P
-
E
V
S
F
F
H
S
E
E
N
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
Blastp_CBE
64.09
46%
-56
- C2 -
-
3NW6
8.1
-
A:
[9-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
D
E
-
W
-
E
V
A
R
E
K
I
T
M
S
R
E
--
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
---
K
G
V
V
-
K
D
--
E
--
P
-
E
T
-
R
---
V
A
I
K
T
V
--
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
-
H
H
V
V
R
----
L
L
G
V
-
V
S
Q
G
-
Q
P
T
------
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
------
S
L
R
----
P
-------
E
----
M
------
E
--------
N
--
N
P
---------
V
-------
L
A
PPS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
E
T
D
Y
Y
R
-
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
A
E
Q
P
Y
Q
G
-
L
-
S
-
N
E
Q
-
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
411
Blastp_CBE
64.05
39%
-126
- C2 -
-
2QOH
8.6
-
ABL1_MOUSE
A:
[6-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--
K
-
E
---
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
S
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
423
Blastp_CBE
64.04
39%
-129
- C2 -
-
3K5V
9.3
-
ABL1_MOUSE
B:
[11-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--
K
----
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
S
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
185
Blastp_CBE
64.03
43%
-123
- C2 -
-
4E93
8.6
-
A:
[114-370]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
L
V
L
G
E
Q
--
I
G
R
G
N
F
G
E
V
F
S
G
R
-
L
---
R
A
----------
D
-
N
T
-
L
---
V
A
V
K
S
C
--
R
-
E
T
L
P
P
D
L
K
A
K
-
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
H
-
P
N
I
V
R
----
L
I
G
V
-
C
T
Q
K
-
Q
P
I
------
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
---------------------------------
T
--------
E
--
G
A
---------
R
-------
L
R
---
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
---
E
K
--
N
V
L
K
I
S
D
F
G
M
S
R
---
E
---------------
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
-
L
G
A
S
P
Y
P
N
-
L
-
S
-
N
Q
Q
-
T
R
E
F
V
E
K
-------
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
---
E
L
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
415
Blastp_CBE
63.96
39%
-129
- C2 -
-
6HD4
9.7
-
ABL1_MOUSE
B:
[11-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--
K
----
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
S
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
414
Blastp_CBE
63.96
39%
-132
- C2 -
-
6HD6
9.9
-
ABL1_MOUSE
A:
[11-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--
K
-
E
--
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
S
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
407
Blastp_CBE
63.96
39%
-119
- C2 -
-
3KFA
11.7
-
ABL1_MOUSE
A:
[6-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--
K
-
E
D
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
S
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
426
Blastp_CBE
63.94
39%
-127
- C2 -
-
1OPJ
10.0
-
ABL1_MOUSE
B:
[11-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--
K
-
E
D
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
S
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
470
Blastp_CBE
63.89
39%
-120
- C2 -
-
2G2H
8.9
-
ABL1_HUMAN
A:
[8-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
K
Y
S
-----------
L
-
T
---
V
A
V
K
T
L
--
K
-
E
D
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
P
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
137
Blastp_CBE
63.89
41%
-62
- C2 -
-
4YNE
8.3
-
A:
[4-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
G
I
R
V
-
H
-
H
I
K
R
R
D
I
V
L
K
W
E
--
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
---
H
N
L
L
-
P
------
D
-
K
M
-
L
---
V
A
V
K
A
L
--
K
-
E
------
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
-
Q
H
I
V
R
----
F
F
G
V
-
C
T
E
G
-
R
P
L
------
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
------
S
H
G
----
P
-------
D
----
A
------
K
LLAGGEDV
A
--
P
G
---------
P
-------
L
G
---
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
F
G
M
--------
S
T
D
Y
Y
-----
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
-
L
-
S
-
N
T
E
-
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
L
Q
A
L
----
A
Q
A
-
P
P
V
Y
L
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
453
Blastp_CBE
63.83
40%
-120
- C2 -
-
3QRJ
8.5
-
ABL1_HUMAN
B:
[11-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
K
Y
S
-----------
L
-
T
---
V
A
V
K
T
L
--
K
-
E
D
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
158
Blastp_CBE
63.76
41%
-93
- C2 -
-
5JFX
8.8
-
A:
[14-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
H
-
H
I
K
R
R
D
I
V
L
K
W
E
--
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
---
H
N
L
L
-
P
E
--
Q
--
D
-
K
M
-
L
---
V
A
V
K
A
L
--
K
-
E
-
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
-
Q
H
I
V
R
----
F
F
G
V
-
C
T
E
G
-
R
P
L
------
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
------
S
H
G
----
P
--------------------V-------
A
--
P
G
---------
P
-------
L
G
---
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
F
G
----------------------
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
-
L
-
S
-
N
T
E
-
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
L
Q
A
L
----
A
Q
A
-
P
P
V
Y
L
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
427
Blastp_CBE
63.73
39%
-123
- C2 -
-
1OPJ
9.3
-
ABL1_MOUSE
A:
[11-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--
K
-
E
D
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
S
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
424
Blastp_CBE
63.73
39%
-130
- C2 -
-
3K5V
9.9
-
ABL1_MOUSE
A:
[11-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--
K
-
E
D
-
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
S
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
416
Blastp_CBE
63.71
39%
-132
- C2 -
-
6HD4
9.4
-
ABL1_MOUSE
A:
[11-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--
K
-
E
D
-
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
S
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
499
Blastp_CBE
63.69
40%
-125
- C2 -
-
2HYY
10.1
-
ABL1_HUMAN
D:
[6-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--
K
-
E
--
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
474
Blastp_CBE
63.68
40%
-128
- C2 -
-
3QRK
9.3
-
ABL1_HUMAN
A:
[11-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
K
Y
S
-----------
L
-
T
---
V
A
V
K
T
L
--
K
-
E
D
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
500
Blastp_CBE
63.63
40%
-127
- C2 -
-
2HYY
9.4
-
ABL1_HUMAN
C:
[6-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--
K
-
E
-
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
---
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
489
Blastp_CBE
63.57
39%
-128
- C2 -
-
3PYY
10.4
-
ABL1_HUMAN
A:
[19-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--
K
-----
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
184
Blastp_CBE
63.61
43%
-123
- C2 -
-
6JMF
6.8
-
A:
[112-368]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
L
V
L
G
E
Q
--
I
G
R
G
N
F
G
E
V
F
S
G
R
-
L
---
R
A
----------
D
-
N
T
-
L
---
V
A
V
K
S
C
--
R
-
E
T
L
P
P
D
L
K
A
K
-
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
H
-
P
N
I
V
R
----
L
I
G
V
-
C
T
Q
K
-
Q
P
I
------
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
---------------------------------
T
--------
E
--
G
A
---------
R
-------
L
R
---
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
---
E
K
--
N
V
L
K
I
S
D
F
G
M
S
R
---
E
E
A
D
G
V
Y
A
A
-
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
-
L
G
A
S
P
Y
P
N
-
L
-
S
-
N
Q
Q
-
T
R
E
F
V
E
K
-------
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
---
E
L
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
135
Blastp_CBE
63.59
41%
-63
- C2 -
-
6J5L
6.7
-
A:
[5-297]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
I
R
V
-
H
-
H
I
K
R
R
D
I
V
L
K
W
E
--
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
---
H
N
L
---------
D
-
K
M
-
L
---
V
A
V
K
A
L
--
K
-
E
-
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
-
Q
H
I
V
R
----
F
F
G
V
-
C
T
E
G
-
R
P
L
------
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
------
S
H
G
----
P
-------
D
----
A
------
K
LLAGGEDV
A
--
P
G
---------
P
-------
L
G
---
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
F
G
-------
I
Y
S
T
D
Y
Y
R
-
V
---
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
-
L
-
S
-
N
T
E
-
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
L
Q
A
L
----
A
Q
A
-
P
P
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
483
Blastp_CBE
63.58
39%
-130
- C2 -
-
6NPV
10.0
-
ABL1_HUMAN
A:
[19-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--
K
------
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
417
Blastp_CBE
63.57
39%
-124
- C2 -
-
3MSS
9.6
-
ABL1_MOUSE
D:
[11-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
---------
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
S
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
-
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
495
Blastp_CBE
63.51
39%
-125
- C2 -
-
2HZI
10.2
-
ABL1_HUMAN
A:
[10-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
K
Y
S
-----------
L
-
T
---
V
A
V
K
T
L
--
K
-
E
D
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
468
Blastp_CBE
63.48
39%
-122
- C2 -
-
2G2I
4.2
-
ABL1_HUMAN
A:
[4-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
---
G
E
V
Y
E
G
V
-
W
---
K
K
Y
S
-----------
L
-
T
---
V
A
V
K
T
L
--
K
-
E
D
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
P
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
447
Blastp_CBE
63.47
39%
-125
- C2 -
-
2G1T
6.8
-
ABL1_HUMAN
C:
[7-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--
K
-
E
D
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
463
Blastp_CBE
63.48
39%
-129
- C2 -
-
4ZOG
7.4
-
ABL1_HUMAN
B:
[6-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--
K
-
E
D
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
---
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
159
Blastp_CBE
63.47
41%
-87
- C2 -
-
5JFW
9.1
-
A:
[14-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
H
-
H
I
K
R
R
D
I
V
L
K
W
E
--
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
---
H
N
L
L
-
P
E
--
Q
--
D
-
K
M
-
L
---
V
A
V
K
A
L
--
K
-
E
-
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
-
Q
H
I
V
R
----
F
F
G
V
-
C
T
E
G
-
R
P
L
------
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
------
S
H
G
----
P
--------------------V-------
A
--
P
G
---------
P
-------
L
G
---
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
F
G
----------------------
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
-
L
-
S
-
N
T
E
-
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
L
Q
A
L
----
A
Q
A
-
P
P
V
Y
L
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
420
Blastp_CBE
63.39
39%
-127
- C2 -
-
3MSS
10.0
-
ABL1_MOUSE
A:
[11-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
---------
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
S
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
-
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
476
Blastp_CBE
63.38
40%
-125
- C2 -
-
3QRI
9.8
-
ABL1_HUMAN
A:
[11-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
K
Y
S
-----------
L
-
T
---
V
A
V
K
T
L
--
K
-
E
D
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
439
Blastp_CBE
63.33
38%
-118
- C2 -
-
2IVS
2.4
-
B:
[19-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
K
N
L
V
L
G
K
T
--
L
G
E
G
E
F
G
K
V
V
K
A
T
-
A
---
F
H
L
K
-
G
R
--
A
--
G
-
Y
T
-
T
---
V
A
V
K
M
L
--
K
-
E
N
A
S
P
S
E
L
R
D
-
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
-
P
H
V
I
K
----
L
Y
G
A
-
C
S
Q
D
-
G
P
L
------
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
------
E
S
R
----
K
--------------------------------
R
---------
A
-------
L
T
---
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
---
A
E
G
--
R
K
M
K
I
S
D
F
G
L
S
R
---
D
V
------------
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
-
L
G
G
N
P
Y
P
G
-
I
-
P
-
P
E
R
-
L
F
N
L
L
K
T
-------
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
---
D
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
464
Blastp_CBE
63.32
39%
-125
- C2 -
-
4ZOG
7.2
-
ABL1_HUMAN
A:
[5-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--
K
-
E
D
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
485
Blastp_CBE
63.28
39%
-132
- C2 -
-
6NPU
9.5
-
ABL1_HUMAN
A:
[19-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--
K
------
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
187
Blastp_CBE
63.28
43%
-122
- C2 -
-
3BKB
8.4
-
A:
[114-370]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
L
V
L
G
E
Q
--
I
G
R
G
N
F
G
E
V
F
S
G
R
-
L
---
R
A
----------
D
-
N
T
-
L
---
V
A
V
K
S
C
--
R
-
E
T
L
P
P
D
L
K
A
K
-
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
H
-
P
N
I
V
R
----
L
I
G
V
-
C
T
Q
K
-
Q
P
I
------
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
---------------------------------
T
--------
E
--
G
A
---------
R
-------
L
R
---
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
---
E
K
--
N
V
L
K
I
S
D
F
G
M
S
R
---
E
E
A
D
G
V
Y
A
A
-
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
-
L
G
A
S
P
Y
P
N
-
L
-
S
-
N
Q
Q
-
T
R
E
F
V
E
K
-------
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
---
E
L
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
487
Blastp_CBE
63.23
39%
-130
- C2 -
-
6NPE
9.5
-
ABL1_HUMAN
A:
[19-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--
K
------
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
Blastp_CBE
63.22
46%
-54
- C2 -
-
3NW5
7.0
-
A:
[9-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
D
E
-
W
-
E
V
A
R
E
K
I
T
M
S
R
E
--
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
---
K
G
V
V
-
K
D
--
E
--
P
-
E
T
-
R
---
V
A
I
K
T
V
--
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
-
H
H
V
V
R
----
L
L
G
V
-
V
S
Q
G
-
Q
P
T
------
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
------
S
L
R
----
P
-------
E
----
M
------
E
--------
N
--
N
P
---------
V
-------
L
A
PPS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
E
T
D
Y
Y
R
-
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
A
E
Q
P
Y
Q
G
-
L
-
S
-
N
E
Q
-
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
170
Blastp_CBE
63.17
41%
-49
- C2 -
-
5WR7
10.4
-
A:
[5-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
Q
Y
------
F
S
D
A
C
V
-
H
-
H
I
K
R
R
D
I
V
L
K
W
E
--
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
---
H
N
L
L
-
P
E
--
Q
--
D
-
K
M
-
L
---
V
A
V
K
A
L
--
K
-
E
-
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
-
Q
H
I
V
R
----
F
F
G
V
-
C
T
E
G
-
R
P
L
------
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
------
S
H
G
----
P
-------
D
----
A
------
K
LLAGGEDV
A
--
P
G
---------
P
-------
L
G
---
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
F
G
M
S
R
---
D
I
Y
S
T
D
Y
Y
R
-
V
G
--
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
-
L
-
S
-
N
T
E
-
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
L
Q
A
L
----
A
Q
A
-
P
P
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
161
Blastp_CBE
63.15
41%
-89
- C2 -
-
5JFS
9.2
-
A:
[14-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
H
-
H
I
K
R
R
D
I
V
L
K
W
E
--
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
---
H
N
L
L
-
P
E
--
Q
--
D
-
K
M
-
L
---
V
A
V
K
A
L
--
K
-
E
-
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
-
Q
H
I
V
R
----
F
F
G
V
-
C
T
E
G
-
R
P
L
------
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
------
S
H
G
----
P
--------------------V-------
A
--
P
G
---------
P
-------
L
G
---
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
F
G
----------------------
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
-
L
-
S
-
N
T
E
-
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
L
Q
A
L
----
A
Q
A
-
P
P
V
Y
L
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
419
Blastp_CBE
63.14
39%
-125
- C2 -
-
3MSS
10.6
-
ABL1_MOUSE
B:
[11-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
---------
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
S
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
-
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
413
Blastp_CBE
63.12
39%
-126
- C2 -
-
6HD6
10.4
-
ABL1_MOUSE
B:
[11-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--
K
----
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
S
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
449
Blastp_CBE
63.06
39%
-126
- C2 -
-
2G1T
6.7
-
ABL1_HUMAN
A:
[7-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--
K
-
E
D
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
448
Blastp_CBE
63.06
39%
-127
- C2 -
-
2G1T
6.9
-
ABL1_HUMAN
B:
[5-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--
K
-
E
D
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
493
Blastp_CBE
63.04
39%
-127
- C2 -
-
3CS9
11.1
-
ABL1_HUMAN
A:
[10-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
K
Y
S
-----------
L
-
T
---
V
A
V
K
T
L
--
K
-----
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
467
Blastp_CBE
62.99
39%
-125
- C2 -
-
2G2I
4.6
-
ABL1_HUMAN
B:
[7-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
----
G
E
V
Y
E
G
V
-
W
---
K
K
Y
S
-----------
L
-
T
---
V
A
V
K
T
L
--
K
-
E
D
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
P
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
418
Blastp_CBE
62.98
39%
-128
- C2 -
-
3MSS
9.4
-
ABL1_MOUSE
C:
[11-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
---------
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
S
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
-
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
429
Blastp_CBE
62.96
39%
-119
- C2 -
-
1M52
9.5
-
ABL1_MOUSE
A:
[11-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--
K
-
E
D
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
S
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
Blastp_CBE
62.92
46%
-60
- C2 -
-
3LW0
5.0
-
IGF1R_HUMAN
B:
[6-285]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
D
E
-
W
-
E
V
A
R
E
K
I
T
M
S
R
E
--
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
---
K
G
V
V
-
K
D
--
E
--
P
-
E
T
-
R
---
V
A
I
K
T
V
--
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
-
H
H
V
V
R
----
L
L
G
V
-
V
S
Q
G
-
Q
P
T
------
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
------
S
L
R
----
P
----------------------------------------------------PPS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
E
T
D
Y
Y
R
----
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
A
E
Q
P
Y
Q
G
-
L
-
S
-
N
E
Q
-
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
371
Blastp_CBE
62.89
39%
-123
- C2 -
-
3IK3
11.3
-
ABL1_MOUSE
B:
[6-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--
K
-
E
D
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
S
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
445
Blastp_CBE
62.83
39%
-121
- C2 -
-
3UE4
6.3
-
ABL1_HUMAN
A:
[8-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--
K
-
E
D
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
436
Blastp_CBE
62.80
39%
-130
- C2 -
-
3OXZ
11.8
-
ABL1_MOUSE
A:
[6-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
---------
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
S
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
--------------
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
374
Blastp_CBE
62.77
39%
-120
- C2 -
-
3OY3
11.7
-
ABL1_MOUSE
B:
[6-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--
K
-
E
D
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
S
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
431
Blastp_CBE
62.75
39%
-123
- C2 -
-
1IEP
10.0
-
ABL1_MOUSE
A:
[11-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--
K
-
E
D
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
S
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
Blastp_CBE
62.75
45%
-64
- C2 -
-
1JQH
4.4
-
C:
[6-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
V
Y
V
P
D
E
-
W
-
E
V
A
R
E
K
I
T
M
S
R
E
--
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
---
K
G
V
V
-
K
D
--
E
--
P
-
E
T
-
R
---
V
A
I
K
T
V
--
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
-
H
H
V
V
R
----
L
L
G
V
-
V
S
Q
G
-
Q
P
T
------
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
------
S
L
R
----
P
-------
E
----------------------------------
V
-------
L
A
PPS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
--
F
T
V
K
I
G
D
F
G
M
T
----------
Y
Y
R
-
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
A
E
Q
P
Y
Q
G
-
L
-
S
-
N
E
Q
-
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
505
Blastp_CBE
62.73
39%
-121
- C2 -
-
2F4J
7.2
-
ABL1_HUMAN
A:
[7-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--
K
-
E
D
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
P
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
Blastp_CBE
62.72
46%
-60
- C2 -
-
3LW0
5.9
-
IGF1R_HUMAN
A:
[6-285]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
D
E
-
W
-
E
V
A
R
E
K
I
T
M
S
R
E
--
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
---
K
G
V
V
-
K
D
--
E
--
P
-
E
T
-
R
---
V
A
I
K
T
V
--
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
-
H
H
V
V
R
----
L
L
G
V
-
V
S
Q
G
-
Q
P
T
------
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
------
S
L
R
----
P
----------------------------------------------------PPS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
E
T
D
Y
Y
R
----
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
A
E
Q
P
Y
Q
G
-
L
-
S
-
N
E
Q
-
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
Blastp_CBE
62.66
46%
-61
- C2 -
-
4D2R
7.5
-
A:
[4-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
D
E
-
W
-
E
V
A
R
E
K
I
T
M
S
R
E
--
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
---
K
G
V
V
-
K
D
--
E
--
P
-
E
T
-
R
---
V
A
I
K
T
V
--
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
-
H
H
V
V
R
----
L
L
G
V
-
V
S
Q
G
-
Q
P
T
------
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
------
S
L
R
----
P
-------
E
----
M
------
E
--------
N
--
N
P
---------
V
-------
L
A
PPS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
E
T
D
Y
Y
R
-
K
--
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
A
E
Q
P
Y
Q
G
-
L
-
S
-
N
E
Q
-
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
446
Blastp_CBE
62.65
39%
-123
- C2 -
-
2G1T
6.9
-
ABL1_HUMAN
D:
[1-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
M
S
P
N
Y
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--
K
-
E
D
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
157
Blastp_CBE
62.61
41%
-80
- C2 -
-
6DKW
9.9
-
NTRK1_HUMAN
A:
[14-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
H
-
H
I
K
R
R
D
I
V
L
K
W
E
--
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
---
H
N
L
L
-
P
E
--
Q
--
D
-
K
M
-
L
---
V
A
V
K
A
L
--
K
-
E
-
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
-
Q
H
I
V
R
----
F
F
G
V
-
C
T
E
G
-
R
P
L
------
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
------
S
H
G
----
P
-------
D
----
A
------
K
LLAGGED-----
G
---------
P
-------
L
G
---
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
F
G
----------------------
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
-
L
-
S
-
N
T
E
-
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
L
Q
A
L
----
A
Q
A
-
P
P
V
Y
L
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
Blastp_CBE
62.58
44%
-61
- C2 -
-
3LVP
6.1
-
IGF1R_HUMAN
B:
[36-317]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
V
P
D
E
-
W
-
E
V
A
R
E
K
I
T
M
S
R
E
--
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
---
K
G
V
V
-
K
D
--
E
--
P
-
E
T
-
R
---
V
A
I
K
T
V
--
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
-
H
H
V
V
R
----
L
L
G
V
-
V
S
Q
G
-
Q
P
T
------
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
------
S
L
R
----
P
-------
E
----------------------------------
V
-------
L
A
PPS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
E
T
D
Y
Y
R
-
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
A
E
Q
P
Y
Q
G
-
L
-
S
-
N
E
Q
-
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
Blastp_CBE
62.57
45%
-67
- C2 -
-
5FXQ
7.5
-
A:
[3-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
A
A
D
V
Y
V
P
D
E
-
W
-
E
V
A
R
E
K
I
T
M
S
R
E
--
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
---
K
G
V
V
-
K
D
--
E
--
P
-
E
T
-
R
---
V
A
I
K
T
V
----
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
-
H
H
V
V
R
----
L
L
G
V
-
V
S
Q
G
-
Q
P
T
------
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
------
S
L
R
----
P
-------
E
----
M
------------------
N
P
---------
V
-------
L
A
PPS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
E
T
D
Y
Y
R
----
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
A
E
Q
P
Y
Q
G
-
L
-
S
-
N
E
Q
-
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
406
Blastp_CBE
62.52
39%
-117
- C2 -
-
3KFA
11.6
-
ABL1_MOUSE
B:
[6-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--
K
-
E
D
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
S
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
451
Blastp_CBE
62.47
39%
-122
- C2 -
-
4WA9
8.6
-
ABL1_HUMAN
B:
[7-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--
K
-
E
D
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
502
Blastp_CBE
62.43
40%
-124
- C2 -
-
2HYY
10.6
-
ABL1_HUMAN
A:
[8-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--
K
--
D
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
Blastp_CBE
62.36
46%
-59
- C2 -
-
3LW0
5.7
-
D:
[6-285]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
D
E
-
W
-
E
V
A
R
E
K
I
T
M
S
R
E
--
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
---
K
G
V
V
-
K
D
--
E
--
P
-
E
T
-
R
---
V
A
I
K
T
V
--
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
-
H
H
V
V
R
----
L
L
G
V
-
V
S
Q
G
-
Q
P
T
------
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
------
S
L
R
----
P
----------------------------------------------------PPS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
E
T
D
Y
Y
R
----
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
A
E
Q
P
Y
Q
G
-
L
-
S
-
N
E
Q
-
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
550
Blastp_CBE
62.34
38%
-133
- C2 -
-
6HEV
10.6
-
A:
[19-289]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
R
Q
K
V
--
I
G
A
G
E
F
G
E
V
Y
K
G
M
-
L
-----
K
K
-
E
V
--
P
-----------
V
A
I
K
T
L
--
K
-
A
G
Y
T
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
-
H
N
I
I
R
----
L
E
G
V
-
I
S
K
Y
-
K
P
M
------
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----------------------------------
K
--
D
G
---------
E
-------
F
S
---
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
---
N
--
L
V
C
K
V
S
D
F
G
L
S
--------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
G
E
R
P
Y
W
E
-
L
-
S
-
N
H
E
-
V
M
K
A
I
N
D
-------
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
---
I
L
D
K
L
----
I
R
A
-
P
D
S
L
K
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
486
Blastp_CBE
62.30
39%
-135
- C2 -
-
6NPE
10.1
-
ABL1_HUMAN
B:
[19-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
---------
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
----------------------
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
471
Blastp_CBE
62.19
39%
-120
- C2 -
-
2G2F
4.0
-
ABL1_HUMAN
B:
[9-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
-----
G
E
V
Y
E
G
V
-
W
---
K
K
Y
S
-----------
L
-
T
---
V
A
V
K
T
L
--
K
-
E
D
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
P
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
409
Blastp_CBE
62.19
39%
-127
- C2 -
-
3KF4
8.8
-
ABL1_MOUSE
A:
[6-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--
K
------
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
S
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
459
Blastp_CBE
62.15
38%
-120
- C2 -
-
2HIW
8.7
-
ABL1_HUMAN
A:
[4-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
N
Y
----------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--
K
-
E
D
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
454
Blastp_CBE
62.09
40%
-134
- C2 -
-
3QRJ
8.8
-
ABL1_HUMAN
A:
[12-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
K
Y
S
-----------
L
-
T
---
V
A
V
K
T
L
--------
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
501
Blastp_CBE
62.06
40%
-122
- C2 -
-
2HYY
9.3
-
ABL1_HUMAN
B:
[6-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--
K
-
E
-
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
Blastp_CBE
62.04
46%
-57
- C2 -
-
2OJ9
7.8
-
A:
[9-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
D
E
-
W
-
E
V
A
R
E
K
I
T
M
S
R
E
--
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
---
K
G
V
V
-
K
D
--
E
--
P
-
E
T
-
R
---
V
A
I
K
T
V
--
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
-
H
H
V
V
R
----
L
L
G
V
-
V
S
Q
G
-
Q
P
T
------
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
------
S
L
R
----
P
-------
E
--------------------------------------------PPS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
E
T
D
Y
Y
R
-
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
A
E
Q
P
Y
Q
G
-
L
-
S
-
N
E
Q
-
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
169
Blastp_CBE
62.02
41%
-47
- C2 -
-
6PL1
8.6
-
?
A:
[16-311]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
C
V
-
H
-
H
I
K
R
R
D
I
V
L
K
W
E
--
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
---
H
N
L
L
-
P
E
--
Q
--
D
-
K
M
-
L
---
V
A
V
K
A
L
--
K
-----
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
-
Q
H
I
V
R
----
F
F
G
V
-
C
T
E
G
-
R
P
L
------
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
------
S
H
G
----
P
-------
D
----
A
------
K
LLAGGEDV
A
--
P
G
---------
P
-------
L
G
---
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
F
G
M
S
R
---
D
I
Y
S
T
D
Y
Y
R
-
V
---
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
-
L
-
S
-
N
T
E
-
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
L
Q
A
L
----
A
Q
A
-
P
P
V
Y
L
D
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
160
Blastp_CBE
62.02
41%
-88
- C2 -
-
5JFV
9.1
-
A:
[14-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
H
-
H
I
K
R
R
D
I
V
L
K
W
E
--
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
---
H
N
L
L
-
P
E
--
Q
--
D
-
K
M
-
L
---
V
A
V
K
A
L
--
K
-
E
-
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
-
Q
H
I
V
R
----
F
F
G
V
-
C
T
E
G
-
R
P
L
------
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
------
S
H
G
----
P
--------------------V-------
A
--
P
G
---------
P
-------
L
G
---
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
F
G
----------------------
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
-
L
-
S
-
N
T
E
-
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
L
Q
A
L
----
A
Q
A
-
P
P
V
Y
L
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
491
Blastp_CBE
61.83
39%
-136
- C2 -
-
3CS9
10.7
-
ABL1_HUMAN
C:
[9-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
----------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
K
Y
S
-----------
L
-
T
---
V
A
V
K
T
L
--------
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
-----------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
Blastp_CBE
61.83
46%
-67
- C2 -
-
3I81
7.7
-
A:
[9-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
D
E
-
W
-
E
V
A
R
E
K
I
T
M
S
R
E
--
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
---
K
G
V
V
-
K
D
--
E
--
P
-
E
T
-
R
---
V
A
I
K
T
V
--
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
-
H
H
V
V
R
----
L
L
G
V
-
V
S
Q
G
-
Q
P
T
------
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
------
S
L
R
----
P
-------
E
-----------
E
--------
N
--
N
P
---------
V
-------
L
A
PPS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
E
T
D
Y
Y
R
------
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
A
E
Q
P
Y
Q
G
-
L
-
S
-
N
E
Q
-
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
Blastp_CBE
61.83
44%
-58
- C2 -
-
3LVP
5.3
-
IGF1R_HUMAN
C:
[37-317]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
V
P
D
E
-
W
-
E
V
A
R
E
K
I
T
M
S
R
E
--
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
---
K
G
V
V
-
K
D
--
E
--
P
-
E
T
-
R
---
V
A
I
K
T
V
--
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
-
H
H
V
V
R
----
L
L
G
V
-
V
S
Q
G
-
Q
P
T
------
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
------
S
L
R
----
P
-------
E
----------------------------------
V
-------
L
A
PPS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
E
T
D
Y
Y
R
-
K
--
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
A
E
Q
P
Y
Q
G
-
L
-
S
-
N
E
Q
-
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
465
Blastp_CBE
61.78
39%
-122
- C2 -
-
2E2B
10.7
-
ABL1_HUMAN
B:
[11-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--------
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
---------
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
472
Blastp_CBE
61.76
39%
-122
- C2 -
-
2G2F
4.0
-
ABL1_HUMAN
A:
[7-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
K
Y
S
-----------
L
-
T
---
V
A
V
K
T
L
--
K
-
E
D
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
P
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
503
Blastp_CBE
61.75
39%
-130
- C2 -
-
3DK3
8.2
-
ABL1_MOUSE
B:
[4-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
-------
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
S
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
F
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
P
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
513
Blastp_CBE
61.66
40%
-112
- C2 -
-
2HZ0
7.5
-
ABL1_HUMAN
A:
[6-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--
K
-
E
D
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
578
HHSearch
61.60
36%
-110
- C2 -
-
6BRJ
7.5
-
DDR1_HUMAN
A:
[568-872]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
R
S
R
L
R
F
K
E
K
--
L
G
E
G
Q
F
G
E
V
H
L
C
E
-
V
------------------
L
-
L
---
V
A
V
K
I
L
--
R
-
P
D
A
T
K
N
A
R
N
D
-
F
L
K
E
V
K
I
M
S
R
L
-
K
D
-
P
N
I
I
R
----
L
L
G
V
-
C
V
Q
D
-
D
P
L
------
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
------
A
H
Q
----
L
-------
E
----
D
-------------------
P
---------
T
-------
I
S
---
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
N
-----
F
T
I
K
I
A
D
F
G
M
S
R
---
N
L
Y
A
G
D
Y
Y
R
-
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
-
L
-
T
-
D
E
Q
-
V
I
E
N
A
G
E
FFRDQGR
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
---
F
L
A
E
D
----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
375
Blastp_CBE
61.60
39%
-121
- C2 -
-
3OY3
11.6
-
ABL1_MOUSE
A:
[6-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--
K
-
E
D
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
S
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
473
Blastp_CBE
61.59
40%
-116
- C2 -
-
5HU9
10.8
-
ABL1_HUMAN
A:
[10-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--
K
-
E
D
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
----------
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
Blastp_CBE
61.58
45%
-54
- C2 -
-
5HHW
8.6
-
?
A:
[9-284]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
D
E
-
W
-
E
V
S
R
E
K
I
T
L
L
R
E
--
L
G
Q
G
S
F
G
M
V
Y
E
G
N
-
A
---
R
D
I
I
-
K
G
--
E
--
A
-
E
T
-
R
---
V
A
V
K
T
V
--
N
-
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
C
-
H
H
V
V
R
----
L
L
G
V
-
V
S
K
G
-
Q
P
T
------
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
------
S
L
R
----
P
-------
E
AENN
P
------
G
--------
R
--
P
P
---------
P
--------
T
---
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
---
A
H
D
--
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
E
T
D
Y
Y
R
-
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
-
L
A
E
Q
P
Y
Q
G
-
L
-
S
-
N
E
Q
-
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
372
Blastp_CBE
61.52
39%
-128
- C2 -
-
3IK3
12.1
-
ABL1_MOUSE
A:
[6-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--
K
-
E
D
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
S
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
---------
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
497
Blastp_CBE
61.51
40%
-135
- C2 -
-
2HZ4
8.0
-
ABL1_HUMAN
B:
[6-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
-----
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--
K
-
E
D
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
519
Blastp_CBE
61.42
39%
-129
- C2 -
-
4XEY
5.7
-
ABL1_HUMAN
B:
[118-387]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
------
E
V
Y
E
G
V
-
W
---
K
K
Y
S
-----------
L
-
T
---
V
A
V
K
T
L
------
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
136
Blastp_CBE
61.41
41%
-57
- C2 -
-
4YPS
4.5
-
A:
[4-297]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
G
I
R
V
-
H
-
H
I
K
R
R
D
I
V
L
K
W
E
--
L
G
E
---
G
K
V
F
L
A
E
-
C
---
H
N
L
L
--------
D
-
K
M
-
L
---
V
A
V
K
A
L
-------
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
-
Q
H
I
V
R
----
F
F
G
V
-
C
T
E
G
-
R
P
L
------
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
------
S
H
G
----
P
-------
D
----
A
------
K
LLAGGEDV
A
--
P
G
---------
P
-------
L
G
---
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
--
M
S
R
---
D
I
Y
S
T
D
Y
Y
R
-
V
---
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
-
L
-
S
-
N
T
E
-
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
L
Q
A
L
----
A
Q
A
-
P
P
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
422
Blastp_CBE
61.39
39%
-121
- C2 -
-
3MS9
10.1
-
ABL1_MOUSE
A:
[11-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
---------
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
S
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
--
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
430
Blastp_CBE
61.38
39%
-117
- C2 -
-
1IEP
9.5
-
ABL1_MOUSE
B:
[11-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--
K
-
E
D
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
S
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
553
Blastp_CBE
61.32
38%
-133
- C2 -
-
6HES
10.7
-
A:
[19-289]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
R
Q
K
V
--
I
G
A
G
E
F
G
E
V
Y
K
G
M
-
L
-----
K
K
-
E
V
--
P
-----------
V
A
I
K
T
L
--
K
-
A
G
Y
T
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
-
H
N
I
I
R
----
L
E
G
V
-
I
S
K
Y
-
K
P
M
------
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----------------------------------
K
--
D
G
---------
E
-------
F
S
---
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
---
N
--
L
V
C
K
V
S
D
F
G
L
S
---------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
G
E
R
P
Y
W
E
-
L
-
S
-
N
H
E
-
V
M
K
A
I
N
D
-------
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
---
I
L
D
K
L
----
I
R
A
-
P
D
S
L
K
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
167
Blastp_CBE
61.32
42%
-52
- C2 -
-
4PMM
10.2
-
A:
[2-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
H
-
H
I
K
R
R
D
I
V
L
K
W
E
--
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
---
H
N
L
L
--------
D
-
K
M
-
L
---
V
A
V
K
A
L
--
K
-----
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
-
Q
H
I
V
R
----
F
F
G
V
-
C
T
E
G
-
R
P
L
------
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
------
S
H
G
----
P
-------
D
----
A
------
K
LLAGGEDV
A
--
P
G
---------
P
-------
L
G
---
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
F
G
M
S
R
---
D
I
Y
S
T
D
Y
Y
R
-
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
-
L
-
S
-
N
T
E
-
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
L
Q
A
L
----
A
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
466
Blastp_CBE
61.31
39%
-118
- C2 -
-
2E2B
9.8
-
ABL1_HUMAN
A:
[11-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
-------
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
----
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
Blastp_CBE
61.27
46%
-58
- C2 -
-
3LW0
5.2
-
IGF1R_HUMAN
C:
[6-285]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
D
E
-
W
-
E
V
A
R
E
K
I
T
M
S
R
E
--
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
---
K
G
V
V
-
K
D
--
E
--
P
-
E
T
-
R
---
V
A
I
K
T
V
--
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
-
H
H
V
V
R
----
L
L
G
V
-
V
S
Q
G
-
Q
P
T
------
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
------
S
L
R
----
P
----------------------------------------------------PPS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
E
T
D
Y
Y
R
----
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
A
E
Q
P
Y
Q
G
-
L
-
S
-
N
E
Q
-
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
510
Blastp_CBE
61.24
37%
-44
- C2 -
-
4R7H
9.3
-
A:
[14-339]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
Y
Q
V
---
R
W
K
I
I
E
-----
S
Y
T
F
I
D
P
T
Q
L
P
Y
N
E
-
K
W
E
F
P
R
N
N
L
Q
F
G
K
T
--
L
G
A
G
A
F
G
K
V
V
E
A
T
-
A
---
F
G
L
G
-
K
E
--
D
--
A
-
V
L
-
K
---
V
A
V
K
M
L
--
K
-
S
T
A
H
A
D
E
K
E
A
-
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
-
E
N
I
V
N
----
L
L
G
A
-
C
T
H
G
-
G
P
V
------
L
V
I
T
E
Y
C
T
Y
G
D
L
L
N
F
L
R
------
R
K
A
----
E
-------
A
----
M
------
L
--------
G
--
P
S
LGR------
P
-------
L
E
---
L
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
N
---
G
--
H
V
A
K
I
G
D
F
G
L
A
R
---
D
I
M
N
D
S
N
Y
I
-
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
S
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
-
L
G
L
N
P
Y
P
G
I
L
-
V
-
N
S
K
-
F
Y
K
L
V
K
D
-------
G
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
T
S
---
F
L
Q
E
Q
----
A
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
504
Blastp_CBE
61.24
39%
-132
- C2 -
-
3DK3
7.9
-
ABL1_MOUSE
A:
[4-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--
K
-----
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
S
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
F
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
P
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
Blastp_CBE
61.21
46%
-55
- C2 -
-
4IBM
7.0
-
?
A:
[8-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
D
E
-
W
-
E
V
S
R
E
K
I
T
L
L
R
E
--
L
G
Q
G
S
F
G
M
V
Y
E
G
N
-
A
---
R
D
I
I
-
K
G
--
E
--
A
-
E
T
-
R
---
V
A
V
K
T
V
--
N
-
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
C
-
H
H
V
V
R
----
L
L
G
V
-
V
S
K
G
-
Q
P
T
------
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
------
S
L
R
----
P
-------
E
AENN
P
------
G
--------
R
--
P
P
---------
P
--------
T
---
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
H
D
--
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
E
T
D
Y
Y
R
-
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
-
L
A
E
Q
P
Y
Q
G
-
L
-
S
-
N
E
Q
-
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
475
Blastp_CBE
61.16
40%
-126
- C2 -
-
3QRI
8.4
-
ABL1_HUMAN
B:
[11-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
K
Y
S
-----------
L
-
T
---
V
A
V
K
T
L
--------
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
376
Blastp_CBE
61.11
38%
-36
- C2 -
-
3BEA
9.3
-
A:
[13-327]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
---
R
W
K
I
I
E
S
Y
E
G
N
S
Y
T
F
I
D
P
T
Q
L
P
Y
N
E
-
K
W
E
F
P
R
N
N
L
Q
F
G
K
T
--
L
G
A
G
A
F
G
K
V
V
E
A
T
-
A
---
F
G
L
G
-
K
E
--
D
--
A
-
V
L
-
K
---
V
A
V
K
M
L
--
K
-
S
T
A
H
A
D
E
K
E
A
-
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
-
E
N
I
V
N
----
L
L
G
A
-
C
T
H
G
-
G
P
V
------
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R-----
K
S
R
----
V
-------
L
------------------------
S
---------
T
-------
L
S
---
T
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
--
H
V
A
K
I
G
D
F
G
L
A
R
---
D
I
M
N
D
S
N
Y
I
-
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
-
L
G
L
N
P
Y
P
G
-
I
L
V
-
N
S
K
-
F
Y
K
L
V
K
D
-------
G
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
---
F
L
Q
E
Q
----
A
Q
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
482
Blastp_CBE
61.10
39%
-133
- C2 -
-
6NPV
9.7
-
ABL1_HUMAN
B:
[19-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
---------
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
-------------------
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
492
Blastp_CBE
61.08
39%
-140
* C2 *
-
3CS9
10.5
-
ABL1_HUMAN
B:
[10-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
K
Y
S
-----------
L
-
T
---
V
A
V
K
T
L
------
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
-----------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
478
Blastp_CBE
61.05
39%
-129
- C2 -
-
6BL8
6.1
-
ABL1_HUMAN
B:
[1-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
---
Y
G
E
V
Y
E
G
V
-
W
---
K
K
Y
S
-----------
L
-
T
---
V
A
V
K
T
L
--
K
-
E
D
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
S
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
F
T
A
-
H
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
P
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
117
Blastp_CBE
60.94
45%
-69
- C2 -
-
3EKN
7.3
-
A:
[9-284]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
D
E
-
W
-
E
V
S
R
E
K
I
T
L
L
R
E
--
L
G
Q
G
S
F
G
M
V
Y
E
G
N
-
A
---
R
D
I
I
-
K
G
--
E
--
A
-
E
T
-
R
---
V
A
V
K
T
V
--
N
-
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
C
-
H
H
V
V
R
----
L
L
G
V
-
V
S
K
G
-
Q
P
T
------
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
------
S
L
R
----
P
-------
E
AENN
P
------
G
--------
R
--
P
P
---------
P
--------
T
---
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
---
A
H
D
--
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
E
T
D
Y
Y
R
----
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
-
L
A
E
Q
P
Y
Q
G
-
L
-
S
-
N
E
Q
-
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
166
Blastp_CBE
60.93
42%
-61
- C2 -
-
4PMP
8.1
-
A:
[2-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
H
-
H
I
K
R
R
D
I
V
L
K
W
E
--
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
---
H
N
L
L
----------
K
M
-
L
---
V
A
V
K
A
L
--
K
------
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
-
Q
H
I
V
R
----
F
F
G
V
-
C
T
E
G
-
R
P
L
------
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
------
S
H
G
----
P
-------
D
----
A
------
K
LLAGGEDV
A
--
P
G
---------
P
-------
L
G
---
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
F
G
M
S
R
----
I
Y
S
T
D
Y
Y
R
-
V
G
--
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
-
L
-
S
-
N
T
E
-
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
L
Q
A
L
----
A
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
484
Blastp_CBE
60.90
39%
-136
- C2 -
-
6NPU
9.4
-
ABL1_HUMAN
B:
[19-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
---------
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
-------------------
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
175
Blastp_CBE
60.84
42%
-62
- C2 -
-
5KVT
8.2
-
A:
[2-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
H
-
H
I
K
R
R
D
I
V
L
K
W
E
--
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
---
H
N
L
---------
D
-
K
M
-
L
---
V
A
V
K
A
L
--
K
-
E
A
-
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
-
Q
H
I
V
R
----
F
F
G
V
-
C
T
E
G
-
R
P
L
------
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
------
S
H
G
----
P
-------
D
----
A
------
K
LLAGGEDV
A
--
P
G
---------
P
-------
L
G
---
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
F
G
M
S
R
---
D
I
Y
S
T
D
Y
Y
R
-
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
-
L
-
S
-
N
T
E
-
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
479
Blastp_CBE
60.82
39%
-126
- C2 -
-
6BL8
7.7
-
ABL1_HUMAN
A:
[1-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
K
Y
S
-----------
L
-
T
---
V
A
V
K
T
L
--
K
-
E
D
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
S
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
F
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
P
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
549
Blastp_CBE
60.74
38%
-130
- C2 -
-
6HEW
10.9
-
A:
[19-289]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
R
Q
K
V
--
I
G
A
G
E
F
G
E
V
Y
K
G
M
-
L
-----
K
K
-
E
V
--
P
-----------
V
A
I
K
T
L
--
K
-
A
G
Y
T
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
-
H
N
I
I
R
----
L
E
G
V
-
I
S
K
Y
-
K
P
M
------
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----------------------------------
K
--
D
G
---------
E
-------
F
S
---
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
---
N
--
L
V
C
K
V
S
D
F
G
L
S
----------------
G
--
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
G
E
R
P
Y
W
E
-
L
-
S
-
N
H
E
-
V
M
K
A
I
N
D
-------
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
---
I
L
D
K
L
----
I
R
A
-
P
D
S
L
K
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
Blastp_CBE
60.73
44%
-67
- C2 -
-
3LVP
5.8
-
IGF1R_HUMAN
A:
[39-317]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
-
W
-
E
V
A
R
E
K
I
T
M
S
R
E
--
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
---
K
G
V
V
-
K
D
--
E
--
P
-
E
T
-
R
---
V
A
I
K
T
V
--
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
-
H
H
V
V
R
----
L
L
G
V
-
V
S
Q
G
-
Q
P
T
------
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
------
S
L
R
----
P
-------
E
----
M
------
E
------------
P
---------
V
-------
L
A
PPS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
--------
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
A
E
Q
P
Y
Q
G
-
L
-
S
-
N
E
Q
-
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
442
Blastp_CBE
60.70
39%
-130
- C2 -
-
4YC8
5.0
-
ABL1_HUMAN
B:
[8-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
------
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--
K
-
E
D
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
443
Blastp_CBE
60.68
39%
-131
- C2 -
-
4YC8
4.4
-
ABL1_HUMAN
A:
[8-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
------
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
-------
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
Blastp_CBE
60.49
46%
-72
- C2 -
-
1I44
5.2
-
A:
[9-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
-
W
-
E
V
S
R
E
K
I
T
L
L
R
E
--
L
G
Q
G
S
F
G
M
V
Y
E
G
N
-
A
---
R
D
I
I
-
K
G
--
E
--
A
-
E
T
-
R
---
V
A
V
K
T
V
--
N
-
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
C
-
H
H
V
V
R
----
L
L
G
V
-
V
S
K
G
-
Q
P
T
------
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
------
S
L
R
----
P
-------
E
AENN
P
------
G
--------
R
--
P
P
---------
P
--------
T
---
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
H
D
--
F
T
V
K
I
G
D
F
G
M
T
--------------------
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
-
L
A
E
Q
P
Y
Q
G
-
L
-
S
-
N
E
Q
-
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
548
Blastp_CBE
60.25
38%
-131
- C2 -
-
6HEX
10.8
-
A:
[19-289]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
R
Q
K
V
--
I
G
A
G
E
F
G
E
V
Y
K
G
M
-
L
-----
K
K
-
E
V
--
P
-----------
V
A
I
K
T
L
--
K
-
A
G
Y
T
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
-
H
N
I
I
R
----
L
E
G
V
-
I
S
K
Y
-
K
P
M
------
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----------------------------------
K
--
D
G
---------
E
-------
F
S
---
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
---
N
--
L
V
C
K
V
S
D
F
G
L
----------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
G
E
R
P
Y
W
E
-
L
-
S
-
N
H
E
-
V
M
K
A
I
N
D
-------
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
---
I
L
D
K
L
----
I
R
A
-
P
D
S
L
K
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
488
Blastp_CBE
60.25
39%
-133
- C2 -
-
3PYY
10.4
-
ABL1_HUMAN
B:
[19-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
---------
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
-------------------
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
508
Blastp_CBE
60.24
37%
-32
- C2 -
-
6N33
8.9
-
A:
[36-339]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Q
L
P
Y
N
E
-
K
W
E
F
P
R
N
N
L
Q
F
G
K
T
--
L
G
A
G
A
F
G
K
V
V
E
A
T
-
A
---
F
G
L
G
-
K
E
--
D
--
A
-
V
L
-
K
---
V
A
V
K
M
L
--
K
-
S
T
A
H
A
D
E
K
E
A
-
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
-
E
N
I
V
N
----
L
L
G
A
-
C
T
H
G
-
G
P
V
------
L
V
I
T
E
Y
C
T
Y
G
D
L
L
N
F
L
R
------
R
K
A
----
E
-------
A
----
M
------
L
--------
G
--
P
S
LSGR-----
P
-------
L
E
---
L
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
N
---
G
--
H
V
A
K
I
G
D
F
G
L
A
R
---
D
I
M
N
D
S
N
Y
I
-
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
S
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
-
L
G
L
N
P
Y
P
G
I
L
-
V
-
N
S
K
-
F
Y
K
L
V
K
D
-------
G
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
T
S
---
F
L
Q
E
Q
----
A
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
132
Blastp_CBE
60.22
42%
-74
- C2 -
-
4AT5
7.4
-
A:
[7-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
Q
-
H
I
K
R
H
N
I
V
L
K
R
E
--
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
---
Y
N
L
-----------
K
I
-
L
---
V
A
V
K
T
L
--
K
-
D
-
A
S
D
N
A
R
K
D
-
F
H
R
E
A
E
L
L
T
N
L
-
Q
H
-
E
H
I
V
K
----
F
Y
G
V
-
C
V
E
G
-
D
P
L
------
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
------
A
H
G
----
P
-------
D
----
A
VLMAEG
N
--------
P
--
P
T
---------
E
-------
L
T
---
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
E
N
--
L
L
V
K
I
G
D
F
G
M
S
R
---
D
V
Y
S
T
D
Y
Y
R
-
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
-
L
-
S
-
N
N
E
-
V
I
E
C
I
T
Q
-------
G
R
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
165
Blastp_CBE
60.12
42%
-55
- C2 -
-
4PMS
10.6
-
A:
[2-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
H
-
H
I
K
R
R
D
I
V
L
K
W
E
--
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
---
H
N
L
L
--------
D
-
K
M
-
L
---
V
A
V
K
A
L
--
K
-----
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
-
Q
H
I
V
R
----
F
F
G
V
-
C
T
E
G
-
R
P
L
------
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
------
S
H
G
----
P
-------
D
----
A
------
K
LLAGGEDV
A
--
P
G
---------
P
-------
L
G
---
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
F
G
M
S
R
---
D
I
Y
S
T
D
Y
Y
R
-
V
--
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
-
L
-
S
-
N
T
E
-
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
L
Q
A
L
----
A
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
525
Blastp_CBE
60.03
38%
-71
- C2 -
-
6IN0
4.1
-
?
A:
[3-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
E
L
D
A
T
N
I
S
I
D
K
V
--
V
G
A
G
E
F
G
E
V
C
S
G
R
-
L
---
K
-
L
P
-
S
---
K
--
K
-
E
I
-
S
---
V
A
I
K
T
L
--
K
-
V
G
Y
T
E
K
Q
R
R
D
-
F
L
G
E
A
S
I
M
G
Q
F
-
D
H
-
P
N
I
I
R
----
L
E
G
V
-
V
T
K
S
-
K
P
V
------
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
------
K
-----------------------------------
H
--
D
A
---------
Q
-------
F
T
---
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
---
N
--
L
V
C
K
V
S
D
F
G
L
S
R
VL-----------------
I
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
-
Y
G
E
R
P
Y
W
E
-
M
-
S
-
N
Q
D
-
V
I
K
A
V
D
E
-------
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
---
I
L
D
K
L
----
I
R
N
-
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
509
Blastp_CBE
60.05
37%
-32
- C2 -
-
4R7I
7.0
-
?
A:
[37-338]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
L
P
Y
N
E
-
K
W
E
F
P
R
N
N
L
Q
F
G
K
T
--
L
G
A
G
A
F
G
K
V
V
E
A
T
-
A
---
F
G
L
G
-
K
E
--
D
--
A
-
V
L
-
K
---
V
A
V
K
M
L
--
K
-
S
T
A
H
A
D
E
K
E
A
-
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
-
E
N
I
V
N
----
L
L
G
A
-
C
T
H
G
-
G
P
V
------
L
V
I
T
E
Y
C
T
Y
G
D
L
L
N
F
L
R
------
R
K
A
----
E
-------
A
----
M
------
L
--------
G
--
P
S
LSGR-----
P
-------
L
E
---
L
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
N
---
G
--
H
V
A
K
I
G
D
F
G
L
A
R
---
D
I
M
N
D
S
N
Y
I
-
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
S
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
-
L
G
L
N
P
Y
P
G
I
L
-
V
-
N
S
K
-
F
Y
K
L
V
K
D
-------
G
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
T
S
---
F
L
Q
E
Q
----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
Blastp_CBE
60.03
46%
-56
- C2 -
-
4IBM
6.6
-
?
B:
[10-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
-
W
-
E
V
S
R
E
K
I
T
L
L
R
E
--
L
G
Q
G
S
F
G
M
V
Y
E
G
N
-
A
---
R
D
I
I
-
K
G
--
E
--
A
-
E
T
-
R
---
V
A
V
K
T
V
--
N
-
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
C
-
H
H
V
V
R
----
L
L
G
V
-
V
S
----
P
T
------
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
------
S
L
R
----
P
-------
E
AENN
P
------
G
--------
R
--
P
P
---------
P
--------
T
---
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
H
D
--
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
E
T
D
Y
Y
R
-
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
-
L
A
E
Q
P
Y
Q
G
-
L
-
S
-
N
E
Q
-
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
Blastp_CBE
60.02
49%
-53
- C2 -
-
4UXL
7.4
-
A:
[24-306]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
N
L
-
P
-
A
F
P
R
E
K
L
T
L
R
L
L
--
L
G
S
G
A
F
G
E
V
Y
E
G
T
A
V
---
D
I
L
G
-
V
G
--
S
--
G
-
E
I
-
K
---
V
A
V
K
T
L
--
K
-
K
G
S
T
D
Q
E
K
I
E
-
F
L
K
E
A
H
L
M
S
K
F
-
N
H
-
P
N
I
L
K
----
Q
L
G
V
-
C
L
L
N
-
E
P
Q
------
Y
I
I
L
E
L
M
E
G
G
D
L
L
T
Y
L
R
------
K
A
R
----
M
-------
A
----
T
------
F
--------
Y
--
G
P
---------
L
-------
L
T
---
L
V
D
L
V
D
L
C
V
D
I
S
K
G
C
V
Y
L
E
R
M
H
F
I
H
R
D
L
A
A
R
N
C
L
V
S
V
K
D
Y
T
SP
R
I
V
K
I
G
D
F
G
L
A
R
---
D
I
Y
K
---------
E
G
L
L
P
V
R
W
M
A
P
E
S
L
M
D
G
I
F
T
T
Q
S
D
V
W
S
F
G
I
L
I
W
E
I
L
T
-
L
G
H
Q
P
Y
P
A
-
H
-
S
-
N
L
D
-
V
L
N
Y
V
Q
T
-------
G
G
R
L
E
P
P
R
N
C
P
D
D
L
W
N
L
M
T
Q
C
W
A
Q
E
P
D
Q
R
P
T
F
H
R
I
Q
D
---
Q
L
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
Blastp_CBE
60.01
46%
-54
- C2 -
-
3QQU
8.1
-
IGF1R_HUMAN
C:
[4-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
-
W
-
E
V
A
R
E
K
I
T
M
S
R
E
--
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
---
K
G
V
V
-
K
D
--
E
--
P
-
E
T
-
R
---
V
A
I
K
T
V
--
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
-
H
H
V
V
R
----
L
L
G
V
-
V
S
Q
G
-
Q
P
T
------
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
------
S
L
R
----
P
-------
E
----
M
-----------------------------
V
-------
L
A
PPS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
E
T
D
Y
Y
R
-
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
A
E
Q
P
Y
Q
G
-
L
-
S
-
N
E
Q
-
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
458
Blastp_CBE
59.97
38%
-116
- C2 -
-
2HIW
7.3
-
ABL1_HUMAN
B:
[4-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
N
Y
----------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--
K
-
E
D
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
368
Blastp_CBE
59.87
38%
-15
- C2 -
-
2I0V
7.9
-
A:
[10-329]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
Y
Q
V
---
R
W
K
I
I
E
S
Y
E
G
N
S
Y
T
F
I
D
P
T
Q
L
P
Y
N
E
-
K
W
E
F
P
R
N
N
L
Q
F
G
K
T
--
L
G
A
G
A
F
G
K
V
V
E
A
T
-
A
---
F
G
L
G
-
K
E
--
D
--
A
-
V
L
-
K
---
V
A
V
K
M
L
--
K
-
S
T
A
H
A
D
E
K
E
A
-
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
-
E
N
I
V
N
----
L
L
G
A
-
C
T
H
G
-
G
P
V
------
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
------
R
K
R
-----------------------------------------------
Q
-------
L
S
---
S
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
--
H
V
A
K
I
G
D
F
G
L
A
R
---
D
I
M
N
D
S
N
Y
I
-
V
K
G
-
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
-
L
G
L
N
P
Y
P
G
I
L
-
V
-
N
S
K
-
F
Y
K
L
V
K
D
-------
G
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
---
F
L
Q
E
Q
----
A
Q
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
Blastp_CBE
59.83
45%
-69
- C2 -
-
5E1S
7.5
-
A:
[10-285]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
D
E
-
W
-
E
V
S
R
E
K
I
T
L
L
R
E
--
L
G
Q
G
S
F
G
M
V
Y
E
G
N
-
A
---
R
D
I
I
-
K
G
--
E
--
A
-
E
T
-
R
---
V
A
V
K
T
V
--
N
-
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
C
-
H
H
V
V
R
----
L
L
G
V
-
V
S
K
G
-
Q
P
T
------
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
------
S
L
R
----
P
-------
E
AENN
P
------
G
--------
R
--
P
P
---------
P
--------
T
---
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
---
A
H
D
--
F
T
V
K
I
G
D
F
G
M
---------------------
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
-
L
A
E
Q
P
Y
Q
G
-
L
-
S
-
N
E
Q
-
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
433
Blastp_CBE
59.61
39%
-113
- C2 -
-
1FPU
5.1
-
ABL1_MOUSE
A:
[11-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--
K
-
E
D
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
S
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
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S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
528
Blastp_CBE
59.54
37%
-34
- C2 -
-
6T2W
8.8
-
?
A:
[6-329]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
---
R
W
K
I
I
E
S
Y
--
N
S
Y
T
F
I
D
P
T
Q
L
P
Y
N
E
-
K
W
E
F
P
R
N
N
L
Q
F
G
K
T
--
L
G
A
G
A
F
G
K
V
V
E
A
T
-
A
---
F
G
L
G
-
K
E
--
D
--
A
-
V
L
-
K
---
V
A
V
K
M
L
--
K
-
S
T
A
H
A
D
E
K
E
A
-
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
-
E
N
I
V
N
----
L
L
G
A
-
C
T
H
G
-
G
P
V
------
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
------
R
K
A
----
E
-------
A
----
M
------
L
-------------R--------
P
-------
L
E
---
L
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
--
H
V
A
K
I
G
D
F
G
L
A
R
---
D
I
M
N
D
S
N
Y
I
-
V
K
G
N
A
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L
P
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I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
-
L
G
L
N
P
Y
P
G
I
L
-
V
-
N
S
K
-
F
Y
K
L
V
K
D
-------
G
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
---
F
L
Q
E
Q
----
A
Q
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
173
Blastp_CBE
59.47
41%
-141
- C2 -
-
3V5Q
8.1
-
NTRK3_HUMAN
A:
[6-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
H
V
-
Q
-
H
I
K
R
R
D
I
V
L
K
R
E
--
L
------
K
V
F
L
A
E
-
C
---
Y
N
L
S
-
P
T
--
K
--
D
-
K
M
-
L
---
V
A
V
K
A
L
--
P
-
T
L
A
A
R
K
D
----
F
Q
R
E
A
E
L
L
T
N
L
-
Q
H
-
E
H
I
V
K
----
F
Y
G
V
-
C
G
D
G
-
D
P
L
------
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
------
A
H
G
----
P
------------------------------------------
E
-------
L
G
---
L
S
Q
M
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
A
N
--
L
L
V
K
I
G
D
F
G
M
-----
D
V
Y
S
T
D
Y
Y
R
-----
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
-
Y
G
K
Q
P
W
F
Q
-
L
-
S
-
N
T
E
-
V
I
E
C
I
T
Q
-------
G
R
V
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
I
Y
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
179
Blastp_CBE
59.39
44%
-125
- C2 -
-
4CSV
9.6
-
?
A:
[5-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
W
-
E
I
P
R
S
E
I
T
L
E
R
K
--
L
G
S
G
Q
F
G
E
V
Y
E
G
K
-
W
---
R
N
Y
N
-----------
I
-
E
---
V
A
V
K
T
L
--
K
-
E
G
T
M
S
V
E
E
---
F
L
Q
E
A
Q
I
M
K
K
L
-
K
H
-
P
N
L
V
Q
----
L
Y
G
V
-
C
T
K
E
-
P
P
I
------
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
------
D
C
-------------------------
V
--------
N
--
A
Q
---------
A
-------
L
--------
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
N
V
V
K
V
A
D
F
G
----------------------
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
-
Y
G
Q
V
P
Y
P
G
-
M
-
S
-
G
S
E
-
V
I
E
Q
V
E
R
-------
G
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
---
A
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
Blastp_CBE
59.37
46%
-57
- C2 -
-
3QQU
6.8
-
D:
[4-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
-
W
-
E
V
A
R
E
K
I
T
M
S
R
E
--
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
---
K
G
V
V
-
K
D
--
E
--
P
-
E
T
-
R
---
V
A
I
K
T
V
--
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
-
H
H
V
V
R
----
L
L
G
V
-
V
S
Q
G
-
Q
P
T
------
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
------
S
L
R
----
P
-------
E
----
M
-------------------------------------
L
A
PPS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
E
T
D
Y
Y
R
-
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
A
E
Q
P
Y
Q
G
-
L
-
S
-
N
E
Q
-
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
Blastp_CBE
59.37
49%
-52
- C2 -
-
3ZBF
7.0
-
A:
[24-306]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
N
L
-
P
-
A
F
P
R
E
K
L
T
L
R
L
L
--
L
G
S
---
G
E
V
Y
E
G
T
A
V
---
D
I
L
G
-
V
G
--
S
--
G
-
E
I
-
K
---
V
A
V
K
T
L
--
K
-
K
G
S
T
D
Q
E
K
I
E
-
F
L
K
E
A
H
L
M
S
K
F
-
N
H
-
P
N
I
L
K
----
Q
L
G
V
-
C
L
L
N
-
E
P
Q
------
Y
I
I
L
E
L
M
E
G
G
D
L
L
T
Y
L
R
------
K
A
R
----
M
-------
A
----
T
------
F
--------
Y
--
G
P
---------
L
-------
L
T
---
L
V
D
L
V
D
L
C
V
D
I
S
K
G
C
V
Y
L
E
R
M
H
F
I
H
R
D
L
A
A
R
N
C
L
V
S
V
K
D
Y
T
SP
R
I
V
K
I
G
D
F
G
L
A
R
---
D
I
Y
-------------
L
P
V
R
W
M
A
P
E
S
L
M
D
G
I
F
T
T
Q
S
D
V
W
S
F
G
I
L
I
W
E
I
L
T
-
L
G
H
Q
P
Y
P
A
-
H
-
S
-
N
L
D
-
V
L
N
Y
V
Q
T
-------
G
G
R
L
E
P
P
R
N
C
P
D
D
L
W
N
L
M
T
Q
C
W
A
Q
E
P
D
Q
R
P
T
F
H
R
I
Q
D
---
Q
L
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134
Blastp_CBE
59.18
42%
-71
- C2 -
-
4AT3
5.8
-
A:
[7-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
Q
-
H
I
K
R
H
N
I
V
L
K
R
E
--
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
---
Y
N
L
C
----------
K
I
-
L
---
V
A
V
K
T
L
------
A
S
D
N
A
R
K
D
-
F
H
R
E
A
E
L
L
T
N
L
-
Q
H
-
E
H
I
V
K
----
F
Y
G
V
-
C
V
E
G
-
D
P
L
------
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
------
A
H
G
----
P
-------
D
----
A
VLMA--
N
--------
P
--
P
T
---------
E
-------
L
T
---
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
E
N
--
L
L
V
K
I
G
D
F
G
M
S
R
-----
Y
S
T
D
Y
Y
R
-
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
-
L
-
S
-
N
N
E
-
V
I
E
C
I
T
Q
-------
G
R
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
367
Blastp_CBE
59.09
38%
-29
- C2 -
-
2I0Y
7.5
-
?
A:
[14-329]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
---
R
W
K
I
I
E
S
Y
E
--
S
Y
T
F
I
--------
E
-
K
W
E
F
P
R
N
N
L
Q
F
G
K
T
--
L
G
A
G
A
F
G
K
V
V
E
A
T
-
A
---
F
G
L
G
-
K
E
--
D
--
A
-
V
L
-
K
---
V
A
V
K
M
L
--
K
-
S
T
A
H
A
D
E
K
E
A
-
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
-
E
N
I
V
N
----
L
L
G
A
-
C
T
H
G
-
G
P
V
------
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
------
R
K
R
-----------------------------------------------
Q
-------
L
S
---
S
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
--
H
V
A
K
I
G
D
F
G
L
A
R
---
D
I
M
N
D
S
N
Y
I
-
V
K
G
-
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
-
L
G
L
N
P
Y
P
G
I
L
-
V
-
N
S
K
-
F
Y
K
L
V
K
D
-------
G
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
---
F
L
Q
E
Q
----
A
Q
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
432
Blastp_CBE
58.96
39%
-113
- C2 -
-
1FPU
4.9
-
ABL1_MOUSE
B:
[11-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--
K
-
E
D
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
S
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
--------
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
Blastp_CBE
58.94
46%
-56
- C2 -
-
3QQU
6.7
-
IGF1R_HUMAN
A:
[6-282]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
W
-
E
V
A
R
E
K
I
T
M
S
R
E
--
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
---
K
G
V
V
-
K
D
--
E
--
P
-
E
T
-
R
---
V
A
I
K
T
V
--
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
-
H
H
V
V
R
----
L
L
G
V
-
V
S
Q
G
-
Q
P
T
------
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
------
S
L
R
---------------------------------------------------------PPS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
E
T
D
Y
Y
R
-
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
A
E
Q
P
Y
Q
G
-
L
-
S
-
N
E
Q
-
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
133
Blastp_CBE
58.89
42%
-68
- C2 -
-
4AT4
7.8
-
A:
[7-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
Q
-
H
I
K
R
H
N
I
V
L
K
R
E
--
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
---
Y
N
L
C
----------
K
I
-
L
---
V
A
V
K
T
L
--
K
-
D
-
A
S
D
N
A
R
K
D
-
F
H
R
E
A
E
L
L
T
N
L
-
Q
H
-
E
H
I
V
K
----
F
Y
G
V
-
C
V
E
G
-
D
P
L
------
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
------
A
H
G
----
P
-------
D
----
A
VLMA-----------
P
--
P
T
---------
E
-------
L
T
---
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
E
N
--
L
L
V
K
I
G
D
F
G
M
S
R
---
D
V
Y
S
T
D
Y
Y
R
-
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
-
L
-
S
-
N
N
E
-
V
I
E
C
I
T
Q
-------
G
R
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
457
Blastp_CBE
58.85
39%
-29
- C2 -
-
2I1M
7.1
-
A:
[13-327]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
---
R
W
K
I
I
E
S
Y
--
N
S
Y
T
F
I
D
P
T
Q
L
P
Y
N
E
-
K
W
E
F
P
R
N
N
L
Q
F
G
K
T
--
L
G
A
G
A
F
G
K
V
V
E
A
T
-
A
---
F
G
L
G
-
K
E
--
D
--
A
-
V
L
-
K
---
V
A
V
K
M
L
--
K
-
S
T
A
H
A
D
E
K
E
A
-
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
-
E
N
I
V
N
----
L
L
G
A
-
C
T
H
G
-
G
P
V
------
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
RKSRVL
E
T
D
-----------------------------------------------
S
-------
T
A
S--
T
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
--
H
V
A
K
I
G
D
F
G
L
A
R
---
D
I
M
N
D
S
N
Y
I
-
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
-
L
G
L
N
P
Y
P
G
-
I
L
V
-
N
S
K
-
F
Y
K
L
V
K
D
-------
G
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
---
F
L
Q
E
Q
----
A
Q
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
Blastp_CBE
58.61
44%
-62
- C2 -
-
3LVP
6.0
-
D:
[36-317]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
V
P
D
E
-
W
-
E
V
A
R
E
K
I
T
M
S
R
E
--
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
---
K
G
V
V
-
K
D
--
E
--
P
-
E
T
-
R
---
V
A
I
K
T
V
-------------
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
-
H
H
V
V
R
----
L
L
G
V
-
V
S
Q
G
-
Q
P
T
------
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
------
S
L
R
----
P
-------
E
----------------------------------
V
-------
L
A
PPS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
E
T
D
Y
Y
R
-
K
G
G
---
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
A
E
Q
P
Y
Q
G
-
L
-
S
-
N
E
Q
-
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
178
Blastp_CBE
58.56
44%
-122
- C2 -
-
4UEU
5.3
-
?
A:
[4-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
I
P
R
S
E
I
T
L
E
R
K
--
L
G
S
G
Q
F
G
E
V
Y
E
G
K
-
W
---
R
N
Y
N
-----------
I
-
E
---
V
A
V
K
T
L
--
K
-
E
G
T
M
S
V
E
E
---
F
L
Q
E
A
Q
I
M
K
K
L
-
K
H
-
P
N
L
V
Q
----
L
Y
G
V
-
C
T
K
E
-
P
P
I
------
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
------
D
C
E
----
G
-------
H
----
T
------
V
--------
N
--
A
Q
---------
A
-------
L
--------
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
N
V
V
K
V
A
D
F
G
L
A
R
---
L
I
------------
A
K
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
-
Y
G
Q
V
P
Y
P
G
-
M
-
S
-
G
S
E
-
V
I
E
Q
V
E
R
-------
G
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
---
A
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
557
Fugue
58.41
37%
-17
- C2 -
-
3CD3
8.5
-
A:
[1-376]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
I
P
E
V
Q
K
P
L
H
E
Q
L
W
Y
HG
A
I
P
R
A
E
V
A
E
L
L
V
H
S
G
D
F
L
V
R
E
S
Q
E
Y
V
L
SVP
R
H
F
I
I
N
L
Y
R
L
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
P
L
S
G
V
V
L
H
R
A
V
P
-
K
D
K
-
W
-
V
L
N
H
E
D
L
V
L
G
E
Q
--
I
G
R
G
N
F
G
E
V
F
S
G
R
-
L
---
R
A
----------
D
-
N
T
-
L
---
V
A
V
K
S
C
--
R
-
P
----
D
L
K
A
K
-
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
H
-
P
N
I
V
R
----
L
I
G
V
-
C
T
Q
K
-
Q
P
I
------
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
------
T
E
G
----
A
-------
R
------------------------------------------
L
R
---
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
---
E
K
--
N
V
L
K
I
S
D
F
G
M
S
R
---
E
E
-
A
D
G
V
A
A
-
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
-
L
G
A
S
P
Y
P
N
-
L
-
S
-
N
Q
Q
-
T
R
E
F
V
E
K
-------
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
---
E
L
Q
S
I
----
R
K
R
-
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
365
Blastp_CBE
58.37
38%
-18
- C2 -
-
3KRJ
6.7
-
A:
[10-327]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
Y
Q
V
---
R
W
K
I
I
E
S
Y
E
G
N
S
Y
T
F
I
D
P
T
Q
L
P
Y
N
E
-
K
W
E
F
P
R
N
N
L
Q
F
G
K
T
--
L
G
A
G
A
F
G
K
V
V
E
A
T
-
A
---
F
G
L
G
-
K
E
--
D
--
A
-
V
L
-
K
---
V
A
V
K
M
L
--
K
-
S
T
A
H
A
D
E
K
E
A
-
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
-
E
N
I
V
N
----
L
L
G
A
-
C
T
H
G
-
G
P
V
------
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
------
R
K
R
----
P
PG----------------------------------------
Q
-------
L
S
---
S
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
--
H
V
A
K
I
G
D
F
G
L
A
R
---
D
I
M
N
D
S
N
Y
I
-
V
K
G
-
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
-
L
G
L
N
P
Y
P
G
I
L
-
V
-
N
S
K
-
F
Y
K
L
V
K
D
-------
G
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
---
F
L
Q
E
Q
----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
526
Blastp_CBE
58.16
38%
-10
- C2 -
-
4HVS
9.3
-
A:
[26-326]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
S
Y
I
D
P
T
Q
L
P
Y
D
H
-
K
W
E
F
P
R
N
R
L
S
F
G
K
T
--
L
G
A
G
A
F
G
K
V
V
E
A
T
-
A
---
Q
G
L
I
-
K
S
--
D
--
A
-
A
M
-
T
---
V
A
V
K
M
L
--
K
-
P
S
A
H
S
T
E
R
E
A
-
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
-
E
N
I
V
N
----
L
L
G
A
-
C
T
H
G
-
G
P
T
------
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
------
R
K
R
DSFH
S
-------
S
----
D
------
T
--------
S
--
P
A
---------
S
MEDDENA
L
D
---
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
G
--
R
I
T
K
I
C
D
F
G
L
A
R
---
D
I
K
N
D
S
N
Y
V
-
D
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
S
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
-
L
G
S
S
P
Y
P
G
-
M
P
V
-
D
S
K
-
F
Y
K
M
I
K
E
-------
G
F
R
M
S
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
D
K
R
P
T
F
K
Q
I
V
Q
---
D
I
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
164
Blastp_CBE
58.10
42%
-62
- C2 -
-
4PMT
7.0
-
A:
[2-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
H
-
H
I
K
R
R
D
I
V
L
K
W
E
--
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
---
H
N
L
---------
D
-
K
M
-
L
---
V
A
V
K
A
L
-------------
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
-
Q
H
I
V
R
----
F
F
G
V
-
C
T
E
G
-
R
P
L
------
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
------
S
H
G
----
P
-------
D
----
A
------
K
LLAGGEDV
A
--
P
G
---------
P
-------
L
G
---
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
F
--
S
R
---
D
I
Y
S
T
D
Y
Y
R
-
V
---
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
-
L
-
S
-
N
T
E
-
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
L
Q
A
L
----
A
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
118
Blastp_CBE
57.93
45%
-76
- C2 -
-
3EKK
7.5
-
A:
[9-284]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
D
E
-
W
-
E
V
S
R
E
K
I
T
L
L
R
E
--
L
G
Q
G
S
F
G
M
V
Y
E
G
N
-
A
---
R
D
I
I
-
K
G
--
E
--
A
-
E
T
-
R
---
V
A
V
K
T
V
--
N
-
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
C
-
H
H
V
V
R
----
L
L
G
V
-
V
S
K
G
-
Q
P
T
------
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
------
S
L
R
----
P
-------
E
AENN
P
------
G
--------
R
--
P
P
---------
P
--------
T
---
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
---
A
H
D
--
F
T
V
K
I
G
D
F
----------------------
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
-
L
A
E
Q
P
Y
Q
G
-
L
-
S
-
N
E
Q
-
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
477
Blastp_CBE
57.67
38%
-44
- C2 -
-
3LCD
6.6
-
?
A:
[24-320]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
N
S
Y
T
F
I
D
P
T
Q
L
P
Y
N
E
-
K
W
E
F
P
R
N
N
L
Q
F
G
K
T
--
L
G
A
G
A
F
G
K
V
V
E
A
T
-
A
---
F
G
L
G
-
K
E
--
D
--
A
-
V
L
-
K
---
V
A
V
K
M
L
--
K
-
S
T
A
H
A
D
E
K
E
A
-
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
-
E
N
I
V
N
----
L
L
G
A
-
C
T
H
G
-
G
P
V
------
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
RKA---
E
A
D
----
L
-------
D
----------------------------------
P
-------
L
E
---
L
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
--
H
V
A
K
I
G
D
F
G
L
A
R
---
D
I
M
--
S
N
Y
I
-
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
-
L
G
L
N
P
Y
P
G
I
L
-
V
-
N
S
K
-
F
Y
K
L
V
K
D
-------
G
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
---
F
L
Q
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
425
Blastp_CBE
57.67
39%
-114
- C2 -
-
2HZN
6.8
-
ABL1_MOUSE
A:
[11-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
---
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
-----
D
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
S
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
440
Blastp_CBE
57.56
38%
-49
- C2 -
-
2IVS
5.2
-
RET_HUMAN
A:
[19-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
K
N
L
V
L
G
K
T
--
L
G
E
G
E
F
G
K
V
V
K
A
T
-
A
---
F
H
L
K
-
G
R
--
A
--
G
-
Y
T
-
T
---
V
A
V
K
M
L
--
K
-
E
N
A
S
P
S
E
L
R
D
-
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
-
P
H
V
I
K
----
L
Y
G
A
-
C
S
Q
D
-
G
P
L
------
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
------
E
S
R
----
K
VGPGYL--------------------------
R
---------
A
-------
L
T
---
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
---
A
E
G
--
R
K
M
K
I
S
D
F
G
L
S
R
---
D
V
Y
E
E
D
S
Y
V
-
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
-
L
G
G
N
P
Y
P
G
-
I
-
P
-
P
E
R
-
L
F
N
L
L
K
T
-------
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
---
D
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
511
Blastp_CBE
57.55
37%
-17
- C2 -
-
4HW7
8.6
-
A:
[36-338]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Q
L
P
Y
N
E
-
K
W
E
F
P
R
N
N
L
Q
F
G
K
T
--
L
G
A
G
A
F
G
K
V
V
E
A
T
-
A
---
F
G
L
G
-
K
E
--
D
--
A
-
V
L
-
K
---
V
A
V
K
M
L
--
K
-
S
T
A
H
A
D
E
K
E
A
-
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
-
E
N
I
V
N
----
L
L
G
A
-
C
T
H
G
-
G
P
V
------
L
V
I
T
E
Y
C
T
Y
G
D
L
L
N
F
L
R
------
R
K
A
----
E
-------
A
----
M
------
L
--------
G
--
P
S
GR-------
P
-------
L
E
---
L
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
N
---
G
--
H
V
A
K
I
G
D
F
G
L
A
R
---
D
I
M
N
D
S
N
Y
I
-
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
S
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
-
L
G
L
N
P
Y
P
G
I
L
-
V
-
N
S
K
-
F
Y
K
L
V
K
D
-------
G
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
T
S
---
F
L
Q
E
Q
----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
579
HHSearch
57.23
36%
-62
- C2 -
-
6BSD
5.4
-
DDR1_HUMAN
A:
[567-872]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
P
R
S
R
L
R
F
K
E
K
--
L
G
E
G
Q
F
G
E
V
H
L
C
E
-
V
---
D
S
------------
P
L
-
L
---
V
A
V
K
I
L
--
R
-
P
D
A
T
K
N
A
R
N
D
-
F
L
K
E
V
K
I
M
S
R
L
-
K
D
-
P
N
I
I
R
----
L
L
G
V
-
C
V
Q
D
-
D
P
L
------
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
------
A
H
Q
----
L
-------
E
----
D
KA----------------
G
P
---------
T
-------
I
S
---
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
N
-----
F
T
I
K
I
A
D
F
G
--
R
---
N
L
Y
A
G
D
Y
Y
R
-
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
-
L
-
T
-
D
E
Q
-
V
I
E
N
A
G
E
FFRDQGR
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
---
F
L
A
E
D
----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
588
HHSearch
57.06
37%
-35
- C2 -
-
4ASD
9.0
-
A:
[60-348]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
R
L
K
L
G
K
P
--
L
G
R
G
A
F
G
Q
V
I
E
A
D
-
A
---
F
G
I
D
-
K
T
--
A
--
T
-
C
R
-
T
---
V
A
V
K
M
L
--
K
-
E
G
A
T
H
S
E
H
R
A
-
L
M
S
E
L
K
I
L
I
H
I
-
G
H
H
L
N
V
V
N
----
L
L
G
A
-
C
T
K
P
G
G
P
L
------
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
------
S
K
R
----
N
-------
E
----
F
------
V
--------
P
YY
K
D
---------
F
-------
L
T
---
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
-----
N
V
V
K
I
C
D
F
G
L
A
R
---
D
I
Y
K
D
P
D
Y
V
-
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
A
S
P
Y
P
G
-
V
-
K
-
I
D
E
E
F
C
R
R
L
K
E
-------
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
---
H
L
G
N
L
----
L
Q
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
189
Blastp_CBE
57.04
39%
-62
- C2 -
-
6KZC
9.7
-
?
A:
[3-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
Q
-
H
I
K
R
R
D
I
V
L
K
R
E
--
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
---
Y
N
L
S
-
P
T
--
K
--
D
-
K
M
-
L
---
V
A
V
K
A
L
KD
P
-
T
L
A
A
R
K
D
----
F
Q
R
E
A
E
L
L
T
N
L
-
Q
H
-
E
H
I
V
K
----
F
Y
G
V
-
C
G
D
G
-
D
P
L
------
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
------
A
H
G
----
P
DA-------------------------------G--------
E
-------
L
G
---
L
S
Q
M
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
A
N
--
L
L
V
K
I
G
D
F
G
M
S
R
----
V
Y
S
T
D
Y
Y
R
L---
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
-
Y
G
K
Q
P
W
F
Q
-
L
-
S
-
N
T
E
-
V
I
E
C
I
T
Q
-------
G
R
V
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
I
Y
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
Blastp_CBE
56.83
46%
-22
- C2 -
-
3QQU
6.6
-
IGF1R_HUMAN
B:
[3-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
D
E
-
W
-
E
V
A
R
E
K
I
T
M
S
R
E
--
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
---
K
G
V
V
-
K
D
--
E
--
P
-
E
T
-
R
---
V
A
I
K
T
V
--
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
-
H
H
V
V
R
----
L
L
G
V
-
V
S
Q
G
-
Q
P
T
------
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
------
S
L
R
---------------------------------------------------------PS-
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
E
T
D
Y
Y
R
-
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
A
E
Q
P
Y
Q
G
-
L
-
S
-
N
E
Q
-
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
328
Blastp_CBE
56.79
38%
-33
- C2 -
-
2PWL
4.8
-
FGFR2_HUMAN
B:
[31-314]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
K
P
--
L
G
E
G
A
F
G
Q
V
V
M
A
E
-
A
---
V
G
I
D
-
K
D
--
K
PK
E
-
A
V
-
T
---
V
A
V
K
M
L
--
K
-
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
H
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
------
A
R
R
----
P
-------
P
----
G
--------------------E--------
Q
-------
M
T
---
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
--
N
V
M
K
I
A
D
F
G
L
A
R
---
D
I
N
N
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
I
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
581
HHSearch
56.57
39%
-43
- C2 -
-
5A46
2.7
-
B:
[35-324]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-
E
L
P
R
D
R
L
V
L
G
K
P
--
L
G
E
G
C
F
G
Q
V
V
L
A
E
-
A
---
I
G
L
-D
K
P
--
N
--
R
-
V
T
-
K
---
V
A
V
K
M
L
--
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
------
A
R
R
----
P
-------
P
-----H-----
N
--------
P
--
E
E
---------
Q
-------
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
-----
N
V
M
K
I
A
D
F
G
L
A
R
---
D
I
H
H
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
V
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
R
I
----
V
A
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
364
Blastp_CBE
56.09
38%
-21
- C2 -
-
3KRL
5.9
-
A:
[11-325]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
Q
V
---
R
W
K
I
I
----------------
P
Y
N
E
-
K
W
E
F
P
R
N
N
L
Q
F
G
K
T
--
L
G
A
G
A
F
G
K
V
V
E
A
T
-
A
---
F
G
L
G
-
K
E
--
D
--
A
-
V
L
-
K
---
V
A
V
K
M
L
--
K
-
S
T
A
-
A
D
E
K
E
A
-
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
-
E
N
I
V
N
----
L
L
G
A
-
C
T
H
G
-
G
P
V
------
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
------
R
K
R
-----------------------------------------------
Q
-------
L
S
---
S
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
--
H
V
A
K
I
G
D
F
G
L
A
R
---
D
I
M
N
D
S
N
Y
I
-
V
K
G
-
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
-
L
G
L
N
P
Y
P
G
I
L
-
V
-
N
S
K
-
F
Y
K
L
V
K
D
-------
G
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
---
F
L
Q
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
521
Blastp_CBE
55.94
39%
-97
- C2 -
-
2V7A
7.8
-
ABL1_HUMAN
B:
[8-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
K
Y
S
-----------
L
-
T
---
V
A
V
K
T
L
--
K
-
E
D
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
T
A
H
-
A
G
--
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
329
Blastp_CBE
55.93
38%
-36
- C2 -
-
2PWL
5.1
-
FGFR2_HUMAN
A:
[31-314]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
K
P
--
L
G
E
G
A
F
G
Q
V
V
M
A
E
-
A
---
V
G
I
D
-
K
D
--
K
PK
E
-
A
V
-
T
---
V
A
V
K
M
L
--
K
-
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
H
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
------
A
R
R
----
P
---------------------------------E--------
Q
-------
M
T
---
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
--
N
V
M
K
I
A
D
F
G
L
A
R
---
D
I
N
N
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
I
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
190
Blastp_CBE
55.93
40%
-20
- C2 -
-
4K33
7.2
-
A:
[32-315]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
S
R
A
R
L
T
L
G
K
P
--
L
G
E
G
A
F
G
Q
V
V
M
A
E
-
A
---
I
G
I
D
-
K
D
RA
A
--
K
-
P
V
-
T
---
V
A
V
K
M
L
--
K
-
D
D
A
T
D
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
G
-
G
P
L
------
Y
V
L
V
E
Y
A
A
K
G
N
L
R
E
F
L
R
------
A
R
R
----
P
PGLDYSF
D
----
T
------
S
------------
E
---------
Q
-------
L
T
---
F
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
R
---
D
V
H
N
L
D
Y
Y
K
-
E
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
I
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
H
D
L
Y
M
I
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
188
Blastp_CBE
55.78
39%
-55
- C2 -
-
6KZD
11.4
-
?
A:
[3-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
Q
-
H
I
K
R
R
D
I
V
L
K
R
E
--
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
---
Y
N
L
S
-
P
T
--
K
--
D
-
K
M
-
L
---
V
A
V
K
A
L
KD
P
-
T
L
A
A
R
K
D
----
F
Q
R
E
A
E
L
L
T
N
L
-
Q
H
-
E
H
I
V
K
----
F
Y
G
V
-
C
G
D
G
-
D
P
L
------
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
------
A
H
G
----
P
DA-------------------------------G--------
E
-------
L
G
---
L
S
Q
M
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
A
N
--
L
L
V
K
I
G
D
F
G
M
S
R
---
D
V
Y
S
T
D
Y
Y
R
L---
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
-
Y
G
K
Q
P
W
F
Q
-
L
-
S
-
N
T
E
-
V
I
E
C
I
T
Q
-------
G
R
V
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
I
Y
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
366
Blastp_CBE
55.65
38%
-28
- C2 -
-
3DPK
7.7
-
A:
[14-325]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
---
R
W
K
I
I
E
S
----
S
Y
T
F
I
D
----
P
Y
N
E
-
K
W
E
F
P
R
N
N
L
Q
F
G
K
T
--
L
G
A
G
A
F
G
K
V
V
E
A
T
-
A
---
F
G
L
G
--------
A
-
V
L
-
K
---
V
A
V
K
M
L
--
K
-
S
T
A
H
A
D
E
K
E
A
-
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
-
E
N
I
V
N
----
L
L
G
A
-
C
T
H
G
-
G
P
V
------
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
------
R
-------------------------------------------------
Q
-------
L
S
---
S
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
--
H
V
A
K
I
G
D
F
G
L
A
R
---
D
I
M
N
D
S
N
Y
I
-
V
----
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
-
L
G
L
N
P
Y
P
G
I
L
-
V
-
N
S
K
-
F
Y
K
L
V
K
D
-------
G
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
---
F
L
Q
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
512
Blastp_CBE
55.63
40%
-132
- C2 -
-
2HZ0
9.3
-
ABL1_HUMAN
B:
[6-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
------
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
-------
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
----------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
452
Blastp_CBE
55.58
39%
-125
- C2 -
-
4WA9
7.7
-
ABL1_HUMAN
A:
[10-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
--------------------------
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
---------
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
Y
T
A
-
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
532
Blastp_CBE
55.45
37%
-29
- C2 -
-
4P5Q
4.9
-
A:
[23-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
E
F
A
K
-
E
L
D
A
T
N
I
S
I
D
K
V
--
V
G
A
G
E
F
G
E
V
C
S
G
R
-
L
---
K
-
L
P
-
S
---
K
--
K
-
E
I
-
S
---
V
A
I
K
T
L
--
K
-
V
G
Y
T
E
K
Q
R
R
D
-
F
L
G
E
A
S
I
M
G
Q
F
-
D
H
-
P
N
I
I
R
----
L
E
G
V
-
V
T
K
S
-
K
P
V
------
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
------
K
-----------------------------------
H
--
D
A
---------
Q
-------
F
T
---
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
---
N
S
N
--
L
V
C
K
V
S
D
F
G
L
S
R
-------------------
I
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
-
Y
G
E
R
P
Y
W
E
-
M
-
S
-
N
Q
D
-
V
I
K
A
V
D
E
-------
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
---
I
L
D
K
L
----
I
R
N
-
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
537
Blastp_CBE
55.32
37%
-24
- C2 -
-
4G2F
5.0
-
A:
[23-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
E
F
A
K
-
E
L
D
A
T
N
I
S
I
D
K
V
--
V
G
A
G
E
F
G
E
V
C
S
G
R
-
L
---
K
-
L
P
-
S
---
K
--
K
-
E
I
-
S
---
V
A
I
K
T
L
--
K
-
V
G
Y
T
E
K
Q
R
R
D
-
F
L
G
E
A
S
I
M
G
Q
F
-
D
H
-
P
N
I
I
R
----
L
E
G
V
-
V
T
K
S
-
K
P
V
------
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
------
K
-----------------------------------
H
--
D
A
---------
Q
-------
F
T
---
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
---
N
S
N
--
L
V
C
K
V
S
D
F
G
L
S
R
VL------------------
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
-
Y
G
E
R
P
Y
W
E
-
M
-
S
-
N
Q
D
-
V
I
K
A
V
D
E
-------
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
---
I
L
D
K
L
----
I
R
N
-
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
292
Blastp_CBE
55.29
39%
-39
- C2 -
-
3C4F
6.4
-
B:
[9-292]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
P
--
L
G
E
G
A
F
G
Q
V
V
L
A
E
-
A
---
I
G
L
D
-
K
D
K-
P
--
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
------
A
R
R
----
P
-----------------------------P-
E
E
---------
Q
-------
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
R
---
D
I
H
H
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
V
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
523
Blastp_CBE
55.26
37%
-34
- C2 -
-
2QOC
5.0
-
A:
[10-282]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A
K
-
E
L
D
A
T
N
I
S
I
D
K
V
--
V
G
A
G
E
F
G
E
V
C
S
G
R
-
L
---
K
-
L
P
-
S
---
K
--
K
-
E
I
-
S
---
V
A
I
K
T
L
--
K
-
V
G
Y
T
E
K
Q
R
R
D
-
F
L
G
E
A
S
I
M
G
Q
F
-
D
H
-
P
N
I
I
R
----
L
E
G
V
-
V
T
K
S
-
K
P
V
------
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
------
K
-----------------------------------
H
--
D
A
---------
Q
-------
F
T
---
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
---
N
S
N
--
L
V
C
K
V
S
D
F
G
L
S
R
VLE
D
--------------
K
I
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
-
Y
G
E
R
P
Y
W
E
-
M
-
S
-
N
Q
D
-
V
I
K
A
V
D
E
-------
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
---
I
L
D
K
L
----
I
R
N
-
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
304
Blastp_CBE
55.15
38%
-27
- C2 -
-
5A46
2.0
-
FGFR1_HUMAN
A:
[36-329]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
P
--
L
G
E
G
C
F
G
Q
V
V
L
A
E
-
A
---
I
G
L
D
-
K
D
K-
P
--
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
------
A
R
R
----
P
PGL----------------------------
E
E
---------
Q
-------
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
R
---
D
---
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
V
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
DLD
R
I
V
A
L
----
T
S
N
-
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
522
Blastp_CBE
54.74
39%
-94
- C2 -
-
2V7A
6.7
-
ABL1_HUMAN
A:
[7-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
K
Y
S
-----------
L
-
T
---
V
A
V
K
T
L
--
K
-
E
D
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
T
A
H
-
A
G
--
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
256
Blastp_CBE
54.70
39%
-10
- C2 -
-
4UWB
2.3
-
FGFR1_HUMAN
A:
[16-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
P
--
L
G
E
G
A
F
G
Q
V
V
L
A
E
-
A
---
I
G
L
D
-
K
D
K-
P
--
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
------
A
R
R
----
P
PGLEYS------
P
------
S
--------
H
NP
E
E
---------
Q
-------
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
R
---
D
-
H
H
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
V
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
176
Blastp_CBE
54.57
41%
-49
- C2 -
-
4YMJ
6.8
-
B:
[6-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
H
V
-
Q
-
H
I
K
R
R
D
I
V
L
K
R
E
--
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
---
Y
N
L
S
-
P
T
--
K
--
D
-
K
M
-
L
---
V
A
V
K
A
L
KD
P
-
T
L
A
A
R
K
D
----
F
Q
R
E
A
E
L
L
T
N
L
-
Q
H
-
E
H
I
V
K
----
F
Y
G
V
-
C
G
D
G
--
P
L
------
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
------
A
H
G
----
P
---------------------------------G--------
E
-------
L
G
---
L
S
Q
M
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
A
N
--
L
L
V
K
I
G
D
F
G
M
S
R
---
D
V
Y
S
T
D
Y
Y
R
----
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
-
Y
G
K
Q
P
W
F
Q
-
L
-
S
-
N
T
E
-
V
I
E
C
I
T
Q
-------
G
R
V
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
I
Y
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
524
Blastp_CBE
54.54
39%
-18
- C2 -
-
3GQI
5.4
-
A:
[24-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
P
--
L
G
E
G
A
F
G
Q
V
V
L
A
E
-
A
---
I
G
L
D
-
K
D
K-
P
--
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
------
A
R
R
----
P
PGLEFSF
N
----
P
------
S
--------
H
NP
E
E
---------
Q
-------
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
R
---
D
I
H
H
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
V
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
354
Blastp_CBE
54.53
38%
-33
- C2 -
-
4J99
5.1
-
B:
[31-314]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
K
P
--
L
G
E
G
A
F
G
Q
V
V
M
A
E
-
A
---
V
G
I
D
-
K
D
--
K
PK
E
-
A
V
-
T
---
V
A
V
K
M
L
--
K
-
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
------
A
R
R
----
P
-------
P
----
G
------
M
--------
E
--
Y
S
YD-------
Q
-------
M
T
---
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
--
N
V
M
K
I
A
D
F
G
L
A
R
---
D
I
N
N
I
D
Y
Y
K
-
T
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
I
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
243
Blastp_CBE
54.42
39%
-40
- C2 -
-
5O49
4.3
-
B:
[16-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
P
--
L
G
E
G
A
F
G
Q
V
V
L
A
E
-
A
---
I
G
L
D
-----
P
--
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
------
A
R
R
----
P
PG------------------------------
E
---------
Q
-------
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
--------
H
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
V
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
204
Blastp_CBE
54.38
38%
-39
- C2 -
-
3GQL
6.2
-
FGFR1_HUMAN
A:
[24-326]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
P
--
L
G
E
G
A
F
G
Q
V
V
L
A
E
-
A
---
I
G
L
D
-
K
D
K-
P
--
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
------
A
R
R
----
P
P-------------------------------
E
---------
Q
-------
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
R
----------------
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
V
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
DLD
R
I
V
A
L
----
T
S
N
-
Q
E
Y
L
D
L
S
M
P
L
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
540
Blastp_CBE
54.26
39%
-94
- C2 -
-
2GQG
5.7
-
ABL1_HUMAN
A:
[11-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
K
Y
S
-----------
L
-
T
---
V
A
V
K
T
L
--
K
-
E
D
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
T
A
H
-
A
G
--
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
302
Blastp_CBE
54.23
39%
-14
- C2 -
-
5VND
3.3
-
FGFR1_HUMAN
A:
[16-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
P
--
L
G
E
G
A
F
G
Q
V
V
L
A
E
-
A
---
I
G
L
D
-
K
D
K-
P
--
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
C
A
S
K
G
N
L
R
E
Y
L
Q
------
A
R
R
----
P
PGLEYSY
N
----
P
------
S
--------
H
NP
E
E
---------
Q
-------
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
R
---
D
-
H
H
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
V
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
555
Blastp_CBE
54.16
38%
-41
- C2 -
-
6FNH
4.0
-
EPHA2_HUMAN
B:
[19-288]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
R
Q
K
V
--
I
G
A
G
E
F
G
E
V
Y
K
G
M
-
L
KTS---
K
-
E
V
--
P
-----------
V
A
I
K
T
L
--
K
-
A
G
Y
T
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
-
H
N
I
I
R
----
L
E
G
V
-
I
S
K
Y
-
K
P
M
------
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----------------------------------
K
--
D
G
---------
E
-------
F
S
---
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
---
N
--
L
V
C
K
V
S
D
F
G
L
S
R
VLE
D
D
P
E
A
----------
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
G
E
R
P
Y
W
E
-
L
-
S
-
N
H
E
-
V
M
K
A
I
N
D
-------
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
---
I
L
D
K
L
----
I
R
A
-
P
D
S
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
174
Blastp_CBE
54.14
42%
-59
- C2 -
-
5I8A
6.4
-
A:
[5-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
H
-
H
I
K
R
R
D
I
V
L
K
W
E
--
L
G
E
---
G
K
V
F
L
A
E
-
C
---
H
N
------------
K
M
-
L
---
V
A
V
K
A
L
--
K
----------
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
-
Q
H
I
V
R
----
F
F
G
V
-
C
T
E
G
-
R
P
L
------
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
------
S
H
G
----
P
-------
D
----
A
------
K
LLAGGEDV
A
--
P
G
---------
P
-------
L
G
---
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
--
L
V
V
K
I
G
D
F
G
-
S
R
---
D
I
-
S
T
D
Y
Y
R
-
V
---
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
-
L
-
S
-
N
T
E
-
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
---
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
455
Blastp_CBE
54.01
37%
-24
- C2 -
-
5UI0
5.0
-
B:
[31-314]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
K
P
--
L
G
E
G
A
F
G
Q
V
V
M
A
E
-
A
---
V
G
I
D
-
K
D
--
K
PK
E
-
A
V
-
T
---
V
A
V
K
M
L
--
K
-
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
------
A
R
R
----
P
-------
P
----
G
------
M
--------
E
--
Y
S
YDINRVPEE
Q
-------
M
T
---
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
--
N
V
M
K
I
A
D
F
G
L
A
R
---
D
I
N
N
I
D
Y
Y
K
-
M
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
I
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
334
Blastp_CBE
53.88
38%
-18
- C2 -
-
4J98
4.9
-
FGFR2_HUMAN
B:
[31-314]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
K
P
--
L
G
E
G
A
F
G
Q
V
V
M
A
E
-
A
---
V
G
I
D
-
K
D
--
K
PK
E
-
A
V
-
T
---
V
A
V
K
M
L
--
K
-
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
------
A
R
R
----
P
-------
P
----
G
------
M
--------
E
--
Y
S
YDINRVPEE
Q
-------
M
T
---
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
--
N
V
M
K
I
A
D
F
G
L
A
R
---
D
I
N
N
I
D
Y
Y
K
-
Q
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
I
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
355
Blastp_CBE
53.87
38%
-38
- C2 -
-
4J99
5.5
-
FGFR2_HUMAN
A:
[31-314]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
K
P
--
L
G
E
G
A
F
G
Q
V
V
M
A
E
-
A
---
V
G
I
D
-
K
D
--
K
PK
E
-
A
V
-
T
---
V
A
V
K
M
L
--
K
-
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
------
A
R
R
----
P
------------------------------------------
Q
-------
M
T
---
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
--
N
V
M
K
I
A
D
F
G
L
A
R
---
D
I
N
--
D
Y
Y
K
---
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
I
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
254
Blastp_CBE
53.85
39%
-17
- C2 -
-
4UWC
2.2
-
FGFR1_HUMAN
A:
[16-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
P
--
L
G
E
G
A
F
G
Q
V
V
L
A
E
-
A
---
I
G
L
D
-
K
D
K-
P
--
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
------
A
R
R
----
P
PGLEYSY-----
P
------
S
--------
H
NP
E
E
---------
Q
-------
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
R
---
D
I
H
H
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
V
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
180
Blastp_CBE
53.85
40%
-29
- C2 -
-
5U6B
6.5
-
D:
[20-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
R
H
K
V
A
L
G
K
T
--
L
G
E
G
E
F
G
A
V
M
E
G
Q
-
L
---
N
----
Q
------
S
-
I
L
-
K
---
V
A
V
K
T
M
--
K
I
A
I
C
T
R
S
E
L
E
D
-
F
L
S
E
A
V
C
M
K
E
F
-
D
H
-
P
N
V
M
R
----
L
I
G
V
-
C
F
-----
R
ESFPAP
V
V
I
L
P
F
M
K
H
G
D
L
H
S
F
L
L
------
Y
S
R
------------
L
----
G
------
D
--------
Q
--
P
V
---------
Y
-------
L
P
---
T
Q
M
L
V
K
F
M
A
D
I
A
S
G
M
E
Y
L
S
T
K
R
F
I
H
R
D
L
A
A
R
N
C
M
L
N
---
E
N
--
M
S
V
C
V
A
D
F
G
L
S
K
---
K
I
Y
N
G
D
Y
Y
----
R
I
A
K
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
S
F
G
V
T
M
W
E
I
A
T
-
R
G
Q
T
P
Y
P
G
-
V
-
E
-
N
S
E
-
I
Y
D
Y
L
R
Q
-------
G
N
R
L
K
Q
P
A
D
C
L
D
G
L
Y
A
L
M
S
R
C
W
E
L
N
P
Q
D
R
P
S
F
T
E
L
R
E
---
D
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
303
Blastp_CBE
53.80
38%
-30
- C2 -
-
5A46
2.7
-
B:
[36-329]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
P
--
L
G
E
G
C
F
G
Q
V
V
L
A
E
-
A
---
I
G
L
---
D
K-
P
--
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
------
A
R
R
----
P
P---------------------------
H
NP
E
E
---------
Q
-------
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
R
---
D
I
H
H
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
V
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
DLD
R
I
V
A
L
----
T
S
N
-
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
352
Blastp_CBE
53.79
38%
-38
- C2 -
-
4J99
5.4
-
?
D:
[31-314]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
K
P
--
L
G
E
G
A
F
G
Q
V
V
M
A
E
-
A
---
V
G
I
D
-
K
D
--
K
PK
E
-
A
V
-
T
---
V
A
V
K
M
L
--
K
-
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
------
A
R
R
-----------------------------------------------
Q
-------
M
T
---
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
--
N
V
M
K
I
A
D
F
G
L
A
R
---
D
I
N
N
I
D
Y
Y
K
-
T
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
I
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
229
Blastp_CBE
53.64
39%
-44
- C2 -
-
5A4C
2.1
-
B:
[14-297]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
P
--
L
G
E
G
A
F
G
Q
V
V
L
A
E
-
A
---
I
G
L
D
-----
P
--
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
------
A
R
R
----
P
P-------------------------------
E
---------
Q
-------
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
--------
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
V
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
241
Blastp_CBE
53.62
39%
-34
- C2 -
-
5O4A
5.3
-
B:
[16-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
P
--
L
G
E
G
A
F
G
Q
V
V
L
A
E
-
A
---
I
G
L
---
D
K-
P
--
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
------
A
R
R
----
P
PGLEYSY------------------------
E
E
---------
Q
-------
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
--------
H
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
V
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
547
Blastp_CBE
53.60
38%
-52
- C2 -
-
6HEY
11.3
-
A:
[19-289]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
R
Q
K
V
--
I
G
A
G
E
F
G
E
V
Y
K
G
M
-
L
KTS-----
E
V
--
P
-----------
V
A
I
K
T
L
--
K
-
A
G
Y
T
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
-
H
N
I
I
R
----
L
E
G
V
-
I
S
K
Y
-
K
P
M
------
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----------------------------------
K
--
D
G
---------
E
-------
F
S
---
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
---
N
--
L
V
C
K
V
S
D
F
G
L
S
-------------------
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
G
E
R
P
Y
W
E
-
L
-
S
-
N
H
E
-
V
M
K
A
I
N
D
-------
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
---
I
L
D
K
L
----
I
R
A
-
P
D
S
L
K
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
353
Blastp_CBE
53.48
38%
-29
- C2 -
-
4J99
5.4
-
?
C:
[31-314]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
K
P
--
L
G
E
G
A
F
G
Q
V
V
M
A
E
-
A
---
V
G
I
D
-
K
D
--
K
PK
E
-
A
V
-
T
---
V
A
V
K
M
L
--
K
-
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
------
A
R
R
----
P
-------
P
----
G
------
M
--------
E
--
Y
S
YD-------
Q
-------
M
T
---
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
--
N
V
M
K
I
A
D
F
G
L
A
R
---
D
I
N
N
I
D
Y
Y
K
-
T
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
I
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
337
Blastp_CBE
53.44
38%
-37
- C2 -
-
4J97
4.2
-
?
C:
[31-314]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
K
P
--
L
G
---
F
G
Q
V
V
M
A
E
-
A
---
V
G
I
D
--------
E
-
A
V
-
T
---
V
A
V
K
M
L
--
K
-
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
------
A
R
R
----
P
-------
P
-------------------------INRVPEE--
Q
-------
M
T
---
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
--
N
V
M
K
I
A
D
F
G
L
A
R
---
D
I
N
N
I
D
Y
Y
K
-
E
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
I
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
517
Blastp_CBE
53.42
37%
-24
- C2 -
-
5EG3
5.8
-
A:
[31-314]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
K
P
--
L
G
E
G
A
F
G
Q
V
V
M
A
E
-
A
---
V
G
I
D
-
K
D
--
K
PK
E
-
A
V
-
T
---
V
A
V
K
M
L
--
K
-
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
------
A
R
R
----
P
-------
P
----
G
--------------------NRVPEE---
Q
-------
M
T
---
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
--
N
V
M
K
I
A
D
F
G
L
A
R
---
D
I
N
N
I
D
F
F
K
-
E
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
I
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
119
Blastp_CBE
53.40
45%
-53
- C2 -
-
1K3A
4.6
-
A:
[1-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
D
E
-
W
-
E
V
A
R
E
K
I
T
M
S
R
E
--
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
---
K
G
V
V
-
K
D
--
E
--
P
-
E
T
-
R
---
V
A
I
K
T
V
--
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
-
H
H
V
V
R
----
L
L
G
V
-
V
S
Q
G
-
Q
P
T
------
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
------
S
L
R
----
P
-------
E
----
M
---------------------------------------PS-
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
--
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
--
E
T
D
R
-
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
A
E
Q
P
Y
Q
G
-
L
-
S
-
N
E
Q
-
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
L
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
---
S
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
539
Blastp_CBE
53.33
39%
-92
- C2 -
-
2GQG
6.3
-
ABL1_HUMAN
B:
[11-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
K
Y
S
-----------
L
-
T
---
V
A
V
K
T
L
--
K
-
E
D
T
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
N
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
T
A
H
-
A
G
--
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
L
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
378
Blastp_CBE
53.31
37%
-29
- C2 -
-
3B2T
4.3
-
FGFR2_HUMAN
A:
[18-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
K
P
--
L
G
E
G
C
F
G
Q
V
V
M
A
E
-
A
---
V
G
I
D
------PK
E
-
A
V
-
T
---
V
A
V
K
M
L
--
K
-
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
------
A
R
R
----
P
-------
P
----------------------------------
Q
-------
M
T
---
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
T
A
R
N
V
L
V
T
---
E
N
--
N
V
M
K
I
A
D
F
G
L
A
R
---
D
I
N
N
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
I
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
291
Blastp_CBE
53.31
39%
-11
- C2 -
-
3JS2
4.3
-
FGFR1_HUMAN
A:
[24-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
P
--
L
G
E
G
A
F
G
Q
V
V
L
A
E
-
A
---
I
G
L
D
-
K
D
K-
P
--
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
------
A
R
R
----
P
PGL-------------------------
H
NP
E
E
---------
Q
-------
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
R
---
D
I
H
H
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
V
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
177
Blastp_CBE
53.26
41%
-46
- C2 -
-
4YMJ
5.9
-
NTRK3_HUMAN
A:
[6-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
H
V
-
Q
-
H
I
K
R
R
D
I
V
L
K
R
E
--
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
---
Y
N
L
S
-
P
T
--
K
--
D
-
K
M
-
L
---
V
A
V
K
A
L
KD
P
-
T
L
A
A
R
K
D
----
F
Q
R
E
A
E
L
L
T
N
L
-
Q
H
-
E
H
I
V
K
----
F
Y
G
V
-
C
G
D
G
-
D
P
L
------
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
------
A
H
G
----
P
---------------------------------G--------
E
-------
L
G
---
L
S
Q
M
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
A
N
--
L
L
V
K
I
G
D
F
G
------
D
V
Y
S
T
D
Y
Y
R
----
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
-
Y
G
K
Q
P
W
F
Q
-
L
-
S
-
N
T
E
-
V
I
E
C
I
T
Q
-------
G
R
V
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
I
Y
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
244
Blastp_CBE
53.24
39%
-34
- C2 -
-
5O49
5.3
-
FGFR1_HUMAN
A:
[16-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
P
--
L
G
E
G
A
F
G
Q
V
V
L
A
E
-
A
---
I
G
L
D
-
K
D
K-
P
--
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
------
A
R
R
----
P
-----------------------------P-
E
E
---------
Q
-------
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
R
---
D
I
H
H
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
V
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
182
Blastp_CBE
53.23
40%
-29
- C2 -
-
5U6B
6.7
-
UFO_HUMAN
B:
[20-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
R
H
K
V
A
L
G
K
T
--
L
G
E
G
E
F
G
A
V
M
E
G
Q
-
L
---
N
----
Q
------
S
-
I
L
-
K
---
V
A
V
K
T
M
--
K
I
A
I
C
T
R
S
E
L
E
D
-
F
L
S
E
A
V
C
M
K
E
F
-
D
H
-
P
N
V
M
R
----
L
I
G
V
-
C
F
-----
R
ESFPAP
V
V
I
L
P
F
M
K
H
G
D
L
H
S
F
L
L
------
Y
S
R
------------
L
----
G
------
D
--------
Q
--
P
V
---------
Y
-------
L
P
---
T
Q
M
L
V
K
F
M
A
D
I
A
S
G
M
E
Y
L
S
T
K
R
F
I
H
R
D
L
A
A
R
N
C
M
L
N
---
E
N
--
M
S
V
C
V
A
D
F
G
L
S
K
---
K
I
Y
N
G
D
Y
Y
----
R
I
A
K
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
S
F
G
V
T
M
W
E
I
A
T
-
R
G
Q
T
P
Y
P
G
-
V
-
E
-
N
S
E
-
I
Y
D
Y
L
R
Q
-------
G
N
R
L
K
Q
P
A
D
C
L
D
G
L
Y
A
L
M
S
R
C
W
E
L
N
P
Q
D
R
P
S
F
T
E
L
R
E
---
D
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
556
Fugue
53.09
41%
-24
- C2 -
-
1IR3
5.7
-
A:
[4-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
V
F
V
P
---
D
E
-
W
-
E
V
S
R
E
K
I
T
L
L
R
E
--
L
G
Q
G
S
F
G
M
V
Y
E
G
N
-
A
---
R
D
I
I
-
K
G
--
E
--
A
-
E
T
-
R
---
V
A
V
K
T
V
--
N
-
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
C
-
H
H
V
V
R
----
L
L
G
V
V
S
K
-
G
-
Q
P
T
------
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
------
S
L
R
----
P
-------
E
----
A
ENN---
P
--------
G
--
R
P
---------
P
-------
P
T
---
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
H
D
--
F
T
V
K
I
G
D
F
G
M
T
-R--
D
I
E
T
D
R
K
G
G
-
K
G
---
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
-
L
A
E
Q
P
Y
Q
G
-
L
-
S
N-
E
Q
-
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
---
L
L
K
D
D
----
L
H
P
-
S
F
P
E
V
S
F
F
H
S
E
E
N
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
347
Blastp_CBE
53.06
38%
-31
- C2 -
-
4J95
4.6
-
FGFR2_HUMAN
A:
[31-314]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
K
P
--
L
G
E
G
A
F
G
Q
V
V
M
A
E
-
A
---
V
G
I
D
-
K
D
--
K
PK
E
-
A
V
-
T
---
V
A
V
K
M
L
--
K
-
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
------
A
R
R
----
P
------------------------------------------
Q
-------
M
T
---
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
--
N
V
M
K
I
A
D
F
G
L
A
R
---
D
I
----
Y
Y
K
-
N
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
I
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
293
Blastp_CBE
53.01
39%
-38
- C2 -
-
3C4F
6.8
-
FGFR1_HUMAN
A:
[9-292]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
P
--
L
G
E
G
A
F
G
Q
V
V
L
A
E
-
A
---
I
G
L
D
-
K
D
K-
P
--
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
------
A
R
R
----
P
-----------------------------P-
E
E
---------
Q
-------
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
R
---
D
I
H
H
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
V
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
262
Blastp_CBE
52.98
39%
-47
- C2 -
-
4NK9
7.3
-
FGFR1_HUMAN
A:
[16-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
P
--
L
G
E
G
A
F
G
Q
V
V
L
A
E
-
A
---
I
G
L
D
--
D
K-
P
--
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
------
A
R
R
----
P
P-------------------------------
E
---------
Q
-------
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
----------
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
V
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
253
Blastp_CBE
52.87
39%
-16
- C2 -
-
4UWC
3.0
-
B:
[16-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
P
--
L
G
E
G
A
F
G
Q
V
V
L
A
E
-
A
---
I
G
L
---
D
K-
P
--
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
------
A
R
R
----
P
PGLEYSY---------------------
H
NP
E
E
---------
Q
-------
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
R
---
D
I
H
H
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
V
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
237
Blastp_CBE
52.86
39%
-38
- C2 -
-
5Z0S
7.2
-
B:
[15-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
P
--
L
G
E
G
A
F
G
Q
V
V
L
A
E
-
A
---
I
G
L
------
P
--
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
------
A
R
R
----
P
-----------------------------P-
E
E
---------
Q
-------
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
R
---
D
-
H
H
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
V
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
203
Blastp_CBE
52.79
38%
-29
- C2 -
-
3GQL
5.8
-
FGFR1_HUMAN
B:
[24-317]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
P
--
L
G
E
G
A
F
G
Q
V
V
L
A
E
-
A
---
I
G
L
D
-
K
D
K-
P
--
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
------
A
R
R
----
P
P----------------------------P-
E
E
---------
Q
-------
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
R
--------------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
V
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
DLD
R
I
V
A
L
----
T
S
N
-
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
357
Blastp_CBE
52.62
38%
-35
- C2 -
-
5UHN
3.6
-
FGFR2_HUMAN
A:
[31-314]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
K
P
--
L
G
E
G
A
F
G
Q
V
V
M
A
E
-
A
---
V
G
I
D
-
K
D
--
K
PK
E
-
A
V
-
T
---
V
A
V
K
M
L
--
K
-
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
H
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
------
A
R
R
--------------------------------------EE-------
Q
-------
M
T
---
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
--
N
V
M
K
I
A
D
F
G
L
A
R
---
D
I
N
N
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
I
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
122
Blastp_CBE
52.51
45%
-55
- C2 -
-
1GAG
5.0
-
A:
[8-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
D
E
-
W
-
E
V
S
R
E
K
I
T
L
L
R
E
--
L
G
Q
G
S
F
G
M
V
Y
E
G
N
-
A
---
R
D
I
I
-
K
G
--
E
--
A
-
E
T
-
R
---
V
A
V
K
T
V
--
N
-
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
C
-
H
H
V
V
R
----
L
L
G
V
-
V
S
K
G
-
Q
P
T
------
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
------
S
L
R
----
P
-------
E
AENN
P
------
G
--------
R
--
P
P
---------
P
--------
T
---
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
H
D
--
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
--
E
T
D
R
-
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
-
L
A
E
Q
P
Y
Q
G
-
L
-
S
-
N
E
Q
-
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
131
Blastp_CBE
52.45
45%
-48
- C2 -
-
4XLV
4.8
-
?
A:
[30-305]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
D
E
-
W
-
E
V
S
R
E
K
I
T
L
L
R
E
--
L
G
Q
G
S
F
G
M
V
Y
E
G
N
-
A
---
R
D
I
I
-
K
G
--
E
--
A
-
E
T
-
R
---
V
A
V
K
T
V
--
N
-
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
C
-
H
H
V
V
R
----
L
L
G
V
-
V
S
K
G
-
Q
P
T
------
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
------
S
L
R
----
P
-------
E
AENN
P
------
G
--------
R
--
P
P
---------
P
--------
T
---
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
H
D
--
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
--
E
T
D
R
-
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
-
L
A
E
Q
P
Y
Q
G
-
L
-
S
-
N
E
Q
-
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
531
Blastp_CBE
52.43
37%
-28
- C2 -
-
4P5Z
8.8
-
A:
[23-306]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
E
F
A
K
-
E
L
D
A
T
N
I
S
I
D
K
V
--
V
G
A
G
E
F
G
E
V
C
S
G
R
-
L
---
K
-
L
P
-
S
---
K
--
K
-
E
I
-
S
---
V
A
I
K
T
L
--
K
-
V
G
Y
T
E
K
Q
R
R
D
-
F
L
G
E
A
S
I
M
G
Q
F
-
D
H
-
P
N
I
I
R
----
L
E
G
V
-
V
T
K
S
-
K
P
V
------
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
------
K
-----------------------------------
H
--
D
A
---------
Q
-------
F
T
---
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
---
N
S
N
--
L
V
C
K
V
S
D
F
------------------------
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
-
Y
G
E
R
P
Y
W
E
-
M
-
S
-
N
Q
D
-
V
I
K
A
V
D
E
-------
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
---
I
L
D
K
L
----
I
R
N
-
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
518
Blastp_CBE
52.39
37%
-30
- C2 -
-
3CLY
5.2
-
FGFR2_HUMAN
A:
[31-328]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
K
P
--
L
G
E
G
A
F
G
Q
V
V
M
A
E
-
A
---
V
G
I
D
-
K
D
--
K
PK
E
-
A
V
-
T
---
V
A
V
K
M
L
--
K
-
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
------
A
R
R
--------------------------------------EE-------
Q
-------
M
T
---
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
--
N
V
M
K
I
A
D
F
G
L
A
R
---
D
I
N
N
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
I
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
DLD
R
I
L
T
L
----
T
T
N
-
E
E
Y
L
D
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
259
Blastp_CBE
52.41
39%
-40
- C2 -
-
4NKA
7.6
-
B:
[16-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
P
--
L
G
E
G
A
F
G
Q
V
V
L
A
E
-
A
---
I
G
L
---
D
K-
P
--
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
------
A
R
R
----
P
P-------------------------------
E
---------
Q
-------
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
---------
H
H
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
V
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
507
Blastp_CBE
52.39
39%
-97
- C2 -
-
3DK7
8.2
-
ABL1_MOUSE
A:
[4-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--
K
-----
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
S
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
T
A
H
-
A
G
--
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
P
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
320
Blastp_CBE
52.37
39%
-47
- C2 -
-
6NVL
7.1
-
FGFR1_HUMAN
A:
[16-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
P
--
L
G
E
G
C
F
G
Q
V
V
L
A
E
-
A
---
I
G
L
D
-
K
D
K-
P
--
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
------
A
R
R
----
P
P-----------------------------------------
Q
-------
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
-----------
Y
Y
K
-
K
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
V
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
242
Blastp_CBE
52.32
39%
-31
- C2 -
-
5O4A
4.7
-
FGFR1_HUMAN
A:
[16-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
P
--
L
G
E
G
A
F
G
Q
V
V
L
A
E
-
A
---
I
G
L
D
-
K
D
K-
P
--
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
------
A
R
R
----
P
PG-----------------------------
E
E
---------
Q
-------
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
R
---
D
I
H
H
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
V
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
284
Blastp_CBE
52.20
42%
-87
- C2 -
-
3CD3
8.5
-
A:
[114-370]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
L
V
L
G
E
Q
--
I
G
R
G
N
F
G
E
V
F
S
G
R
-
L
---
R
A
----------
D
-
N
T
-
L
---
V
A
V
K
S
C
--
R
-----
P
D
L
K
A
K
-
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
H
-
P
N
I
V
R
----
L
I
G
V
-
C
T
Q
K
-
Q
P
I
------
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
---------------------------------
T
--------
E
--
G
A
---------
R
-------
L
R
---
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
---
E
K
--
N
V
L
K
I
S
D
F
G
M
S
R
---
E
-
E
A
D
G
V
A
A
-
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
-
L
G
A
S
P
Y
P
N
-
L
-
S
-
N
Q
Q
-
T
R
E
F
V
E
K
-------
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
---
E
L
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
356
Blastp_CBE
52.16
38%
-40
- C2 -
-
5UHN
2.3
-
B:
[31-314]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
K
P
--
L
G
E
G
A
F
G
Q
V
V
M
A
E
-
A
---
V
G
I
D
-
K
D
--
K
PK
E
-
A
V
-
T
---
V
A
V
K
M
L
--
K
-
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
H
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
------
A
R
R
-----------------------------------------------
Q
-------
M
T
---
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
--
N
V
M
K
I
A
D
F
G
L
A
R
---
D
I
------------
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
I
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129
Blastp_CBE
52.04
45%
-51
- C2 -
-
1RQQ
4.2
-
B:
[10-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
-
W
-
E
V
S
R
E
K
I
T
L
L
R
E
--
L
G
Q
G
S
F
G
M
V
Y
E
G
N
-
A
---
R
D
I
I
-
K
G
--
E
--
A
-
E
T
-
R
---
V
A
V
K
T
V
--
N
-
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
C
-
H
H
V
V
R
----
L
L
G
V
-
V
S
K
G
-
Q
P
T
------
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
------
S
L
R
----
P
-------
E
AENN
P
------
G
--------
R
--
P
P
---------
P
--------
T
---
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
H
D
--
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
--
E
T
D
R
-
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
-
L
A
E
Q
P
Y
Q
G
-
L
-
S
-
N
E
Q
-
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
345
Blastp_CBE
51.98
38%
-29
- C2 -
-
4J95
4.2
-
?
C:
[31-314]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
K
P
--
L
G
E
G
A
F
G
Q
V
V
M
A
E
-
A
---
V
G
I
D
-
K
D
--
K
PK
E
-
A
V
-
T
---
V
A
V
K
M
L
--
K
-
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
------
A
R
R
-----------------------------------------------
Q
-------
M
T
---
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
--
N
V
M
K
I
A
D
F
G
L
A
R
---
D
I
N
N
I
D
Y
Y
K
-
N
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
I
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
506
Blastp_CBE
51.94
39%
-94
- C2 -
-
3DK7
7.7
-
ABL1_MOUSE
B:
[4-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
-------
M
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
S
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
T
A
H
-
A
G
--
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
P
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
238
Blastp_CBE
51.91
39%
-35
- C2 -
-
5Z0S
7.1
-
FGFR1_HUMAN
A:
[15-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
P
--
L
G
E
G
A
F
G
Q
V
V
L
A
E
-
A
---
I
G
L
---
D
K-
P
--
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
------
A
R
R
----
P
-----------------------------P-
E
E
---------
Q
-------
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
R
---
D
I
H
H
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
V
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
533
Blastp_CBE
51.86
37%
-18
- C2 -
-
4P4C
4.2
-
A:
[27-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A
K
-
E
L
D
A
T
N
I
S
I
D
K
V
--
V
G
A
G
E
F
G
E
V
C
S
G
R
-
L
---
K
-
L
P
-
S
---
K
--
K
-
E
I
-
S
---
V
A
I
K
T
L
--
K
-
V
G
Y
T
E
K
Q
R
R
D
-
F
L
G
E
A
S
I
M
G
Q
F
-
D
H
-
P
N
I
I
R
----
L
E
G
V
-
V
T
K
S
-
K
P
V
------
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
------
K
-----------------------------------
H
--
D
A
---------
Q
-------
F
T
---
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
---
N
S
N
--
L
V
C
K
V
S
D
F
------------------------
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
-
Y
G
E
R
P
Y
W
E
-
M
-
S
-
N
Q
D
-
V
I
K
A
V
D
E
-------
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
---
I
L
D
K
L
----
I
R
N
-
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
530
Blastp_CBE
51.79
37%
-19
- C2 -
-
4TWN
10.5
-
A:
[22-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
H
E
F
A
K
-
E
L
D
A
T
N
I
S
I
D
K
V
--
V
G
A
G
E
F
G
E
V
C
S
G
R
-
L
---
K
-
L
P
-
S
---
K
--
K
-
E
I
-
S
---
V
A
I
K
T
L
--
K
-
V
G
Y
T
E
K
Q
R
R
D
-
F
L
G
E
A
S
I
M
G
Q
F
-
D
H
-
P
N
I
I
R
----
L
E
G
V
-
V
T
K
S
-
K
P
V
------
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
------
K
-----------------------------------
H
--
D
A
---------
Q
-------
F
T
---
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
---
N
S
N
--
L
V
C
K
V
S
D
F
G
L
S
R
------------------
K
I
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
-
Y
G
E
R
P
Y
W
E
-
M
-
S
-
N
Q
D
-
V
I
K
A
V
D
E
-------
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
---
I
L
D
K
L
----
I
R
N
-
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
255
Blastp_CBE
51.76
39%
-12
- C2 -
-
4UWB
2.9
-
B:
[16-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
P
--
L
G
E
G
A
F
G
Q
V
V
L
A
E
-
A
---
I
G
L
---
D
K-
P
--
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
------
A
R
R
----
P
PGLEYSY---------------------
H
NP
E
E
---------
Q
-------
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
R
------
H
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
V
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
211
Blastp_CBE
51.74
39%
-46
- C2 -
-
6MZQ
7.1
-
B:
[18-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
P
--
L
G
E
---
G
Q
V
V
L
A
E
-
A
---
I
G
L
D
-
K
D
K-
P
--
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
------
A
R
--------------------------------------------------------
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
-----------------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
V
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
266
Blastp_CBE
51.51
39%
-38
- C2 -
-
4F64
2.6
-
FGFR1_HUMAN
A:
[16-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
P
--
L
-----
G
Q
V
V
L
A
E
-
A
---
I
G
L
------
P
--
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
------
A
R
R
----
P
-----------------------------P-
E
E
---------
Q
-------
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
R
---
D
I
H
H
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
V
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
130
Blastp_CBE
51.51
45%
-51
- C2 -
-
1RQQ
4.4
-
INSR_HUMAN
A:
[10-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
-
W
-
E
V
S
R
E
K
I
T
L
L
R
E
--
L
G
Q
G
S
F
G
M
V
Y
E
G
N
-
A
---
R
D
I
I
-
K
G
--
E
--
A
-
E
T
-
R
---
V
A
V
K
T
V
--
N
-
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
C
-
H
H
V
V
R
----
L
L
G
V
-
V
S
K
G
-
Q
P
T
------
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
------
S
L
R
----
P
-------
E
AENN
P
------
G
--------
R
--
P
P
---------
P
--------
T
---
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
H
D
--
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
--
E
T
D
R
-
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
-
L
A
E
Q
P
Y
Q
G
-
L
-
S
-
N
E
Q
-
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
121
Blastp_CBE
51.49
45%
-51
- C2 -
-
1IR3
5.7
-
A:
[8-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
D
E
-
W
-
E
V
S
R
E
K
I
T
L
L
R
E
--
L
G
Q
G
S
F
G
M
V
Y
E
G
N
-
A
---
R
D
I
I
-
K
G
--
E
--
A
-
E
T
-
R
---
V
A
V
K
T
V
--
N
-
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
C
-
H
H
V
V
R
----
L
L
G
V
-
V
S
K
G
-
Q
P
T
------
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
------
S
L
R
----
P
-------
E
AENN
P
------
G
--------
R
--
P
P
---------
P
--------
T
---
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
H
D
--
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
--
E
T
D
R
-
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
-
L
A
E
Q
P
Y
Q
G
-
L
-
S
-
N
E
Q
-
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
224
Blastp_CBE
51.37
39%
-22
- C2 -
-
5UR1
7.8
-
FGFR1_HUMAN
A:
[18-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
P
--
L
G
E
G
-
F
G
Q
V
V
L
A
E
-
A
---
I
G
L
D
-
K
D
K-
P
--
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
------
A
R
R
----
P
PY-----
N
----
P
------
S
--------
H
NP
E
E
---------
Q
-------
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
----------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
V
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
223
Blastp_CBE
51.18
39%
-47
- C2 -
-
5UR1
8.7
-
B:
[18-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
P
--
L
G
E
G
A
F
G
Q
V
V
L
A
E
-
A
---
I
G
L
---
D
K-
P
--
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
------
A
R
R
----
P
------------------------------------------
Q
-------
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
----------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
V
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
404
Blastp_CBE
51.15
38%
-40
- C2 -
-
5UGL
4.4
-
?
B:
[31-314]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
K
P
--
L
G
E
G
A
F
G
Q
V
V
M
A
E
-
A
---
V
G
I
D
-
K
D
--
K
PK
E
-
A
V
-
T
---
V
A
V
K
M
L
--
K
-
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
------
A
R
R
----
P
--------------------------------------------------
M
T
---
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
--
N
V
M
K
I
A
D
F
G
L
A
R
---
V
I
------------
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
I
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
346
Blastp_CBE
51.15
38%
-30
- C2 -
-
4J95
4.5
-
?
B:
[31-314]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
K
P
--
L
G
E
G
A
F
G
Q
V
V
M
A
E
-
A
---
V
G
I
D
-
K
D
--
K
PK
E
-
A
V
-
T
---
V
A
V
K
M
L
--
K
-
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
------
A
R
R
----
P
------------------------------------------
Q
-------
M
T
---
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
--
N
V
M
K
I
A
D
F
G
L
A
R
---
D
I
N
N
I
D
Y
Y
K
-
N
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
I
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
344
Blastp_CBE
51.04
38%
-41
- C2 -
-
4J95
4.8
-
?
D:
[31-314]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
K
P
--
L
G
E
G
A
F
G
Q
V
V
M
A
E
-
A
---
V
G
I
D
-
K
D
--
K
PK
E
-
A
V
-
T
---
V
A
V
K
M
L
--
K
-
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
------
A
R
R
-----------------------------------------------
Q
-------
M
T
---
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
--
N
V
M
K
I
A
D
F
G
L
A
R
---
D
I
------------
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
I
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
124
Blastp_CBE
50.84
45%
-51
- C2 -
-
3BU5
5.3
-
A:
[10-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
-
W
-
E
V
S
R
E
K
I
T
L
L
R
E
--
L
G
Q
---
G
M
V
Y
E
G
N
-
A
---
R
D
I
I
-
K
G
--
E
--
A
-
E
T
-
R
---
V
A
V
K
T
V
--
N
-
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
C
-
H
H
V
V
R
----
L
L
G
V
-
V
S
K
G
-
Q
P
T
------
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
------
S
L
R
----
P
-------
E
AENN
P
------
G
--------
R
--
P
P
---------
P
--------
T
---
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
H
D
--
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
--
E
T
D
R
-
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
-
L
A
E
Q
P
Y
Q
G
-
L
-
S
-
N
E
Q
-
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
268
Blastp_CBE
50.83
39%
-38
- C2 -
-
4F63
1.8
-
FGFR1_HUMAN
A:
[16-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
P
--
L
-----
G
Q
V
V
L
A
E
-
A
---
I
G
L
------
P
--
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
------
A
R
R
----
P
-----------------------------P-
E
E
---------
Q
-------
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
R
---
D
I
H
H
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
V
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
514
Blastp_CBE
50.79
39%
-100
- C2 -
-
3DK6
5.5
-
ABL1_MOUSE
B:
[5-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
---------
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--------
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
S
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
T
A
H
-
A
G
--
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
P
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
405
Blastp_CBE
50.64
38%
-22
- C2 -
-
5UGL
4.4
-
A:
[31-314]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
K
P
--
L
G
E
G
A
F
G
Q
V
V
M
A
E
-
A
---
V
G
I
D
-
K
D
--
K
PK
E
-
A
V
-
T
---
V
A
V
K
M
L
--
K
-
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
------
A
R
---------------------------------------RVPEE----
Q
-------
M
T
---
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
--
N
V
M
K
I
A
D
F
G
L
A
R
---
V
I
N
N
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
I
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
181
Blastp_CBE
50.59
40%
-48
- C2 -
-
5U6B
7.1
-
UFO_HUMAN
C:
[20-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
R
H
K
V
A
L
G
K
T
--
L
G
E
G
E
F
G
A
V
M
E
G
Q
-
L
---
N
----
Q
D
--
D
--
S
-
I
L
-
K
---
V
A
V
K
T
M
--
K
I
A
I
C
T
R
S
E
L
E
D
-
F
L
S
E
A
V
C
M
K
E
F
-
D
H
-
P
N
V
M
R
----
L
I
G
V
-
C
F
Q
-----PAP---
V
V
I
L
P
F
M
K
H
G
D
L
H
S
F
L
L
------
Y
S
R
------------
L
----
G
------
D
--------
Q
--
P
V
---------
Y
-------
L
P
---
T
Q
M
L
V
K
F
M
A
D
I
A
S
G
M
E
Y
L
S
T
K
R
F
I
H
R
D
L
A
A
R
N
C
M
L
N
---
E
N
--
M
S
V
C
V
A
D
F
G
L
S
K
--------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
S
F
G
V
T
M
W
E
I
A
T
-
R
G
Q
T
P
Y
P
G
-
V
-
E
-
N
S
E
-
I
Y
D
Y
L
R
Q
-------
G
N
R
L
K
Q
P
A
D
C
L
D
G
L
Y
A
L
M
S
R
C
W
E
L
N
P
Q
D
R
P
S
F
T
E
L
R
E
---
D
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
263
Blastp_CBE
50.48
39%
-10
- C2 -
-
4F65
7.3
-
B:
[16-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
P
--
L
G
E
G
A
F
G
Q
V
V
L
A
E
-
A
---
I
G
L
D
-----
P
--
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
------
A
R
R
----
P
------------------------------------------
Q
-------
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
----------
H
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
V
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
377
Blastp_CBE
50.31
37%
-28
- C2 -
-
3B2T
4.1
-
B:
[18-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
K
P
--
L
----
F
G
Q
V
V
M
A
E
-
A
---
V
G
I
---
D
--
K
PK
E
-
A
V
-
T
---
V
A
V
K
M
L
--
K
-
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
------
A
R
R
----
P
-------
P
----------------------------------
Q
-------
M
T
---
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
T
A
R
N
V
L
V
T
---
E
N
--
N
V
M
K
I
A
D
F
G
L
A
R
---
D
I
N
N
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
I
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
120
Blastp_CBE
50.29
45%
-37
- C2 -
-
2Z8C
5.6
-
A:
[5-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
D
E
-
W
-
E
V
S
R
E
K
I
T
L
L
R
E
--
L
G
Q
G
S
F
G
M
V
Y
E
G
N
-
A
---
R
D
I
I
-
K
G
--
E
--
A
-
E
T
-
R
---
V
A
V
K
T
V
--
N
-
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
C
-
H
H
V
V
R
----
L
L
G
V
-
V
S
K
G
-
Q
P
T
------
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
------
S
L
R
----
P
-------
E
AENN
P
------
G
--------
R
--
P
P
---------
P
--------
T
---
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
H
D
--
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
--
E
T
D
R
-
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
-
L
A
E
Q
P
Y
Q
G
-
L
-
S
-
N
E
Q
-
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
515
Blastp_CBE
50.24
39%
-101
- C2 -
-
3DK6
7.3
-
ABL1_MOUSE
A:
[4-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
-
W
-
E
M
E
R
T
D
I
T
M
K
H
K
--
L
--
G
Q
F
G
E
V
Y
E
G
V
-
W
---
K
--------
K
--
Y
-
S
L
-
T
---
V
A
V
K
T
L
--------
E
V
E
E
---
F
L
K
E
A
A
V
M
K
E
I
-
K
H
-
P
N
L
V
Q
----
L
L
G
V
-
C
T
R
E
-
P
P
F
------
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
C
N
----
R
-------
Q
----------------------------------
E
-------
V
S
---
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
--
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
D
T
T
A
H
-
A
G
--
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
G
M
S
P
Y
P
G
-
I
-
D
-
P
S
Q
-
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
---
A
F
E
T
M
----
F
Q
E
-
S
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
363
Blastp_CBE
50.18
37%
-9
- C2 -
-
5U6C
7.0
-
MERTK_HUMAN
A:
[23-315]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
Q
N
K
L
-
E
-
D
V
V
I
D
R
N
L
L
I
L
G
KI
L
G
E
G
E
F
G
S
V
M
E
G
N
-
L
---
K
--
Q
-
E
D
--
G
--
T
-
S
L
-
K
---
V
A
V
K
T
M
--
K
-
L
D
N
S
S
Q
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
-
P
N
V
M
R
LLGV
C
I
E
M
------
I
P
K
P-----
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
------
Y
S
R
----
L
-------
E
-----------
T
--------
G
--
P
K
---------
H
-------
I
P
---
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
--
M
T
V
C
V
A
D
F
G
L
S
---------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
-
R
G
M
T
P
Y
P
G
-
V
-
Q
-
N
H
E
-
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
---
Q
L
E
K
L
----
L
E
S
L
P
D
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
321
Blastp_CBE
49.96
41%
-9
- C2 -
-
6IUP
2.8
-
?
A:
[28-313]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
W
-
E
F
P
R
D
R
L
V
L
G
K
P
--
L
G
E
G
C
F
G
Q
V
V
R
A
E
-
A
---
F
G
M
---
D
--
P
--
A
R
P
D
-
Q
AST
V
A
V
K
M
L
--
K
---
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
G
R
H
-
K
N
I
I
N
----
L
L
G
V
-
C
T
Q
E
-
G
P
L
------
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
------
A
R
R
----
P
-------------------------------
P
R
---------
S
SEGP---
L
S
---
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
R
---
G
V
H
H
I
D
Y
Y
K
-
K
T
S
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
I
-
P
-
V
E
E
-
L
F
S
L
L
R
E
-------
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
---
A
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
183
Blastp_CBE
49.93
40%
-46
- C2 -
-
5U6B
7.1
-
UFO_HUMAN
A:
[20-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
R
H
K
V
A
L
G
K
T
--
L
G
E
G
E
F
G
A
V
M
E
G
Q
-
L
---
N
----
Q
D
--
D
--
S
-
I
L
-
K
---
V
A
V
K
T
M
--
K
I
A
I
C
T
R
S
E
L
E
D
-
F
L
S
E
A
V
C
M
K
E
F
-
D
H
-
P
N
V
M
R
----
L
I
G
V
-
C
F
Q
-----PAP---
V
V
I
L
P
F
M
K
H
G
D
L
H
S
F
L
L
------
Y
S
R
------------
L
----
G
------
D
--------
Q
--
P
V
---------
Y
-------
L
P
---
T
Q
M
L
V
K
F
M
A
D
I
A
S
G
M
E
Y
L
S
T
K
R
F
I
H
R
D
L
A
A
R
N
C
M
L
N
---
E
N
--
M
S
V
C
V
A
D
F
G
L
S
K
--------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
S
F
G
V
T
M
W
E
I
A
T
-
R
G
Q
T
P
Y
P
G
-
V
-
E
-
N
S
E
-
I
Y
D
Y
L
R
Q
-------
G
N
R
L
K
Q
P
A
D
C
L
D
G
L
Y
A
L
M
S
R
C
W
E
L
N
P
Q
D
R
P
S
F
T
E
L
R
E
---
D
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
280
Blastp_CBE
49.58
39%
-13
- C2 -
-
1FGI
6.6
-
B:
[17-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
P
--
L
G
E
G
A
F
G
Q
V
V
L
A
E
-
A
---
I
G
L
------
P
--
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
------
A
R
R
-----------------------------------------------
Q
-------
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
---------
D
Y
Y
K
-
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
V
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
381
Blastp_CBE
49.46
40%
-52
- C2 -
-
5AMN
3.3
-
A:
[19-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
K
N
L
V
L
G
K
T
--
L
G
E
G
E
F
G
K
V
V
K
A
T
-
A
---
F
H
L
K
-
G
R
--
A
--
G
-
Y
T
-
T
---
V
A
V
K
M
L
--
K
-
E
N
A
S
P
S
E
L
R
D
-
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
-
P
H
V
I
K
----
L
Y
G
A
-
C
S
Q
D
-
G
P
L
------
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
------
E
S
R
KV----------------------------------
E
R
---------
A
-------
L
T
---
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
---
A
E
G
--
R
K
M
K
I
S
D
F
G
L
S
R
---
D
V
E
E
D
S
V
K
R
-
S
Q
G
--
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
-
L
G
G
N
P
Y
P
G
-
I
-
P
-
P
E
R
-
L
F
N
L
L
K
T
-------
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
---
D
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
310
Blastp_CBE
49.36
41%
-38
- C2 -
-
4QQ5
11.8
-
A:
[29-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
W
-
E
F
P
R
D
R
L
V
L
G
K
P
--
L
G
E
G
C
F
G
Q
V
V
R
A
E
-
A
---
F
G
M
------------
D
-
Q
AST
V
A
V
K
M
L
--
K
-
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
G
R
H
-
K
N
I
I
N
----
L
L
G
V
-
C
T
Q
E
-
G
P
L
------
Y
V
I
L
E
C
A
A
K
G
N
L
R
E
F
L
R
------
A
R
R
----
P
P------------------------------------------GP-----
L
S
---
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
--------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
I
-
P
-
V
E
E
-
L
F
S
L
L
R
E
-------
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
---
A
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
222
Blastp_CBE
49.22
39%
-11
- C2 -
-
6C18
8.0
-
FGFR1_HUMAN
A:
[18-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
P
--
L
G
----
G
Q
V
V
L
A
E
-
A
---
I
G
L
D
-
K
D
K-
P
--
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
------
A
R
R
----
P
PGSY---
N
----
P
------
S
--------
H
NP
E
E
---------
Q
-------
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
----------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
V
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
546
Blastp_CBE
49.15
38%
1
- C2 -
-
6Q7B
11.1
-
?
A:
[19-289]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
R
Q
K
V
--
I
G
A
G
E
F
G
E
V
Y
K
G
M
-
L
KT----
K
-
E
V
--
P
-----------
V
A
I
K
T
L
--
K
-
A
G
Y
T
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
-
H
N
I
I
R
----
L
E
G
V
-
I
S
K
Y
-
K
P
M
------
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----------------------------------
K
--
D
G
---------
E
-------
F
S
---
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
---
N
--
L
V
C
K
V
S
D
F
G
L
S
----------------
G
--
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
G
E
R
P
Y
W
E
-
L
-
S
-
N
H
E
-
V
M
K
A
I
N
D
-------
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
---
I
L
D
K
L
----
I
R
A
-
P
D
S
L
K
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
309
Blastp_CBE
49.11
41%
-32
- C2 -
-
4R6V
11.5
-
A:
[29-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
W
-
E
F
P
R
D
R
L
V
L
G
K
P
--
L
G
E
G
C
F
G
Q
V
V
R
A
E
-
A
---
F
G
M
------------
D
-
Q
AST
V
A
V
K
M
L
--
K
-
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
G
R
H
-
K
N
I
I
N
----
L
L
G
V
-
C
T
Q
E
-
G
P
L
------
Y
V
I
L
E
C
A
A
K
G
N
L
R
E
F
L
R
------
A
R
R
----
P
P------------------------------------------GP-----
L
S
---
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
---------------------
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
I
-
P
-
V
E
E
-
L
F
S
L
L
R
E
-------
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
---
A
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
386
Blastp_CBE
49.06
38%
-56
- C2 -
-
5K0K
6.5
-
B:
[31-311]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
I
L
G
K
I
--
L
G
E
G
--
G
S
V
M
E
G
N
-
L
---
K
--
Q
-
E
D
--
G
--
T
-
S
L
-
K
---
V
A
V
K
T
-------------------
E
A
A
C
M
K
D
F
-
S
H
-
P
N
V
I
R
LLGV
C
I
E
M
-
S
S
Q
G
-
I
P
K
P-----
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
------
Y
S
R
----
L
-------
E
-----------
T
--------
G
--
P
K
---------
H
-------
I
P
---
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
--
M
T
V
C
V
A
D
F
------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
-
R
G
M
T
P
Y
P
G
-
V
-
Q
-
N
H
E
-
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
---
Q
L
E
K
L
----
L
E
S
L
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
325
Blastp_CBE
49.02
39%
-15
- C2 -
-
6MZW
7.7
-
FGFR1_HUMAN
A:
[18-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
P
--
L
G
E
G
C
F
G
Q
V
V
L
A
E
-
A
---
I
G
L
D
-
K
D
K-
P
--
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
------
A
R
R
----
P
PGLEYSY
N
----
P
------
S
---------P-
E
E
---------
Q
-------
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
----------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
V
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
172
Blastp_CBE
48.61
41%
-28
- C2 -
-
3V5Q
8.2
-
B:
[6-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
H
V
-
Q
-
H
I
K
R
R
D
I
V
L
K
R
E
--
L
G
---
F
-
K
V
F
L
A
E
-
C
---
Y
N
L
S
-
P
T
--
K
--
D
-
K
M
-
L
---
V
A
V
K
A
L
KD
P
-
T
L
A
A
R
K
D
----
F
Q
R
E
A
E
L
L
T
N
L
-
Q
H
-
E
H
I
V
K
----
F
Y
G
V
-
C
--
G
-
D
P
L
------
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
------
A
H
G
----
P
------------------------------------------
E
-------
L
G
---
L
S
Q
M
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
A
N
--
L
L
V
K
I
G
D
F
G
M
-----
D
V
Y
S
T
D
Y
Y
R
-----
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
-
Y
G
K
Q
P
W
F
Q
-
L
-
S
-
N
T
E
-
V
I
E
C
I
T
Q
-------
G
R
V
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
I
Y
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
391
Blastp_CBE
48.54
38%
-58
- C2 -
-
4MH7
4.1
-
MERTK_HUMAN
A:
[31-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
I
L
G
K
I
--
L
G
E
G
E
F
G
S
V
M
E
G
N
-
L
---
K
--
Q
-
E
D
--
G
--
T
-
S
L
-
K
---
V
A
V
K
T
--------------------
A
A
C
M
K
D
F
-
S
H
-
P
N
V
I
R
LLGV
C
I
E
M
-
S
S
Q
G
-
I
P
K
P-----
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
------
Y
S
R
----
L
-------
E
-----------
T
--------
G
--
P
K
---------
H
-------
I
P
---
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
--
M
T
V
C
V
A
D
F
------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
-
R
G
M
T
P
Y
P
G
-
V
-
Q
-
N
H
E
-
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
---
Q
L
E
K
L
----
L
E
S
L---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
545
Blastp_CBE
48.48
38%
2
- C2 -
-
6Q7C
11.5
-
?
A:
[19-289]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
R
Q
K
V
--
I
G
A
--
F
G
E
V
Y
K
G
M
-
L
KT----
K
-
E
V
--
P
-----------
V
A
I
K
T
L
--
K
-
A
G
Y
T
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
-
H
N
I
I
R
----
L
E
G
V
-
I
S
K
Y
-
K
P
M
------
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----------------------------------
K
--
D
G
---------
E
-------
F
S
---
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
---
N
--
L
V
C
K
V
S
D
F
G
L
S
----------------
G
--
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
G
E
R
P
Y
W
E
-
L
-
S
-
N
H
E
-
V
M
K
A
I
N
D
-------
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
---
I
L
D
K
L
----
I
R
A
-
P
D
S
L
K
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
394
Blastp_CBE
48.48
38%
-54
- C2 -
-
3TCP
6.6
-
B:
[31-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
I
L
G
K
I
--
L
G
E
---
G
S
V
M
E
G
N
-
L
---
K
--
Q
-
E
D
--
G
--
T
-
S
L
-
K
---
V
A
V
K
T
M
--
K
---------------
E
A
A
C
M
K
D
F
-
S
H
-
P
N
V
I
R
LLGV
C
I
E
M
-
S
S
Q
G
-
I
P
K
P-----
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
------
Y
S
R
----
L
-------
E
-----------
T
--------
G
--
P
K
---------
H
-------
I
P
---
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
--
M
T
V
C
V
A
D
F
-----------------------
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
-
R
G
M
T
P
Y
P
G
-
V
-
Q
-
N
H
E
-
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
---
Q
L
E
K
L
----
L
E
S
L---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
544
Blastp_CBE
48.33
38%
2
- C2 -
-
6Q7D
11.3
-
?
A:
[19-289]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
R
Q
K
V
--
I
G
A
G
E
F
G
E
V
Y
K
G
M
-
L
KT----
K
-
E
V
--
P
-----------
V
A
I
K
T
L
--
K
-
A
G
Y
T
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
-
H
N
I
I
R
----
L
E
G
V
-
I
S
K
Y
-
K
P
M
------
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----------------------------------
K
--
D
G
---------
E
-------
F
S
---
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
---
N
--
L
V
C
K
V
S
D
F
G
L
---------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
G
E
R
P
Y
W
E
-
L
-
S
-
N
H
E
-
V
M
K
A
I
N
D
-------
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
---
I
L
D
K
L
----
I
R
A
-
P
D
S
L
K
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
306
Blastp_CBE
48.25
41%
-17
- C2 -
-
4TYI
5.5
-
A:
[17-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
W
-
E
F
P
R
D
R
L
V
L
G
K
P
--
L
G
E
G
C
F
G
Q
V
V
R
A
E
-
A
---
F
G
M
---
D
--
P
--
A
R
P
D
-
Q
AST
V
A
V
K
M
L
--
K
-
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
G
R
H
-
K
N
I
I
N
----
L
L
G
V
-
C
T
Q
E
-
G
P
L
------
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
------
A
R
R
----
P
P------------------------------------------P------
L
S
---
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
R
---
G
---------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
I
-
P
-
V
E
E
-
L
F
S
L
L
R
E
-------
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
---
A
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
462
Blastp_CBE
48.13
37%
-50
- C2 -
-
3QUP
6.4
-
A:
[20-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
---
F
T
L
G
R
M
--
L
G
K
G
E
F
G
S
V
R
E
A
Q
-
L
------------------
V
-
K
---
V
A
V
K
M
L
--------
S
S
D
I
E
E
-
F
L
R
E
A
A
C
M
K
E
F
-
D
H
-
P
H
V
A
K
----
L
V
G
V
-
S
L
R
S
----IP----
M
V
I
L
P
F
M
K
H
G
D
L
H
A
F
L
L
------
A
S
R
----
I
-------------------------------
P
F
---------
N
-------
L
P
---
L
Q
T
L
V
R
F
M
V
D
I
A
C
G
M
E
Y
L
S
S
R
N
F
I
H
R
D
L
A
A
R
N
C
M
L
---
A
E
D
--
M
T
V
C
V
A
D
F
G
L
---------------------
L
P
V
K
W
L
A
L
E
S
L
A
D
N
L
Y
T
V
H
S
D
V
W
A
F
G
V
T
M
W
E
I
M
T
-
R
G
Q
T
P
Y
A
G
-
I
-
E
-
N
A
E
-
I
Y
N
Y
L
I
G
-------
G
N
R
L
K
Q
P
P
E
C
M
E
E
V
Y
D
L
M
Y
Q
C
W
S
A
D
P
K
Q
R
P
S
F
T
C
L
R
M
---
E
L
E
N
I
LGH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
543
Blastp_CBE
48.00
38%
-2
- C2 -
-
6Q7E
11.0
-
?
A:
[19-289]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
R
Q
K
V
--
I
G
A
G
E
F
G
E
V
Y
K
G
M
-
L
KT------
E
V
--
P
-----------
V
A
I
K
T
L
--
K
-
A
G
Y
T
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
-
H
N
I
I
R
----
L
E
G
V
-
I
S
K
Y
-
K
P
M
------
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----------------------------------
K
--
D
G
---------
E
-------
F
S
---
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
---
N
--
L
V
C
K
V
S
D
F
G
L
----------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
G
E
R
P
Y
W
E
-
L
-
S
-
N
H
E
-
V
M
K
A
I
N
D
-------
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
---
I
L
D
K
L
----
I
R
A
-
P
D
S
L
K
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
554
Blastp_CBE
47.93
38%
2
- C2 -
-
6FNH
4.4
-
C:
[19-289]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
R
Q
K
V
--
I
G
A
G
E
F
G
E
V
Y
K
G
M
-
L
KT--
G
K
K
-
E
V
--
P
-----------
V
A
I
K
T
L
--
K
-
A
G
Y
T
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
-
H
N
I
I
R
----
L
E
G
V
-
I
S
K
Y
-
K
P
M
------
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----------------------------------
K
--
D
G
---------
E
-------
F
S
---
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
---
N
--
L
V
C
K
V
S
D
F
G
L
----------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
G
E
R
P
Y
W
E
-
L
-
S
-
N
H
E
-
V
M
K
A
I
N
D
-------
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
---
I
L
D
K
L
----
I
R
A
-
P
D
S
L
K
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
265
Blastp_CBE
47.78
39%
-12
- C2 -
-
4F64
2.6
-
B:
[16-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
P
--
L
G
E
G
A
F
G
Q
V
V
L
A
E
-
A
---
I
G
L
------
P
--
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
------
A
R
R
-----------------------------------------------
Q
-------
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
---------
D
Y
Y
K
-
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
V
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
388
Blastp_CBE
47.70
38%
-60
- C2 -
-
4MHA
4.6
-
B:
[31-311]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
I
L
G
K
I
--
L
G
E
G
E
F
G
S
V
M
E
G
N
-
L
---
K
--
Q
-
E
D
--
G
--
T
-
S
L
-
K
---
V
A
V
K
T
M
-----------------------
K
D
F
-
S
H
-
P
N
V
I
R
LLGV
C
I
E
M
-
S
S
Q
G
-
I
P
K
P-----
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
------
Y
S
R
----
L
-------
E
-----------
T
--------
G
--
P
K
---------
H
-------
I
P
---
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
--
M
T
V
C
V
A
D
F
------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
-
R
G
M
T
P
Y
P
G
-
V
-
Q
-
N
H
E
-
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
---
Q
L
E
K
L
----
L
E
S
L
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
551
Blastp_CBE
47.43
38%
1
- C2 -
-
6HEU
11.2
-
A:
[19-289]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
R
Q
K
V
--
I
G
A
G
E
F
G
E
V
Y
K
G
M
-
L
KT----
K
-
E
V
--
P
-----------
V
A
I
K
T
L
--
K
-
A
G
Y
T
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
-
H
N
I
I
R
----
L
E
G
V
-
I
S
K
Y
-
K
P
M
------
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----------------------------------
K
--
D
G
---------
E
-------
F
S
---
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
---
N
--
L
V
C
K
V
S
D
F
G
L
S
---------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
G
E
R
P
Y
W
E
-
L
-
S
-
N
H
E
-
V
M
K
A
I
N
D
-------
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
---
I
L
D
K
L
----
I
R
A
-
P
D
S
L
K
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
385
Blastp_CBE
47.28
38%
-40
- C2 -
-
5K0X
5.8
-
MERTK_HUMAN
A:
[31-312]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
I
L
G
K
I
--
L
G
E
---
G
S
V
M
E
G
N
-
L
---
K
--
Q
-
E
D
--
G
--
T
-
S
L
-
K
---
V
A
V
K
T
M
--
K
-
L
D
N
S
S
Q
--
I
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
-
P
N
V
I
R
LLGV
C
I
E
--------
P
K
P-----
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
------
Y
S
R
----
L
-------
E
-----------
T
--------
G
--
P
K
---------
H
-------
I
P
---
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
--
M
T
V
C
V
A
D
F
G
-----------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
-
R
G
M
T
P
Y
P
G
-
V
-
Q
-
N
H
E
-
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
---
Q
L
E
K
L
----
L
E
S
L
P
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
542
Blastp_CBE
47.26
38%
-0
- C2 -
-
6Q7F
10.0
-
?
A:
[19-289]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
R
Q
K
V
--
I
G
A
G
E
F
G
E
V
Y
K
G
M
-
L
KT------
E
V
--
P
-----------
V
A
I
K
T
L
--
K
-
A
G
Y
T
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
-
H
N
I
I
R
----
L
E
G
V
-
I
S
K
Y
-
K
P
M
------
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----------------------------------
K
--
D
G
---------
E
-------
F
S
---
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
---
N
--
L
V
C
K
V
S
D
F
G
-----------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
G
E
R
P
Y
W
E
-
L
-
S
-
N
H
E
-
V
M
K
A
I
N
D
-------
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
---
I
L
D
K
L
----
I
R
A
-
P
D
S
L
K
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
541
Blastp_CBE
47.11
38%
3
- C2 -
-
6Q7G
11.1
-
?
A:
[19-289]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
R
Q
K
V
--
I
G
A
G
E
F
G
E
V
Y
K
G
M
-
L
KT----
K
-
E
V
--
P
-----------
V
A
I
K
T
L
--
K
-
A
G
Y
T
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
-
H
N
I
I
R
----
L
E
G
V
-
I
S
K
Y
-
K
P
M
------
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----------------------------------
K
--
D
G
---------
E
-------
F
S
---
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
---
N
--
L
V
C
K
V
S
D
F
G
L
----------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
G
E
R
P
Y
W
E
-
L
-
S
-
N
H
E
-
V
M
K
A
I
N
D
-------
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
---
I
L
D
K
L
----
I
R
A
-
P
D
S
L
K
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
383
Blastp_CBE
47.10
38%
-45
- C2 -
-
6MEP
6.4
-
MERTK_HUMAN
A:
[31-312]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
I
L
G
K
I
--
L
G
E
G
E
F
G
S
V
M
E
G
N
-
L
---
K
--
Q
-
E
D
--
G
--
T
-
S
L
-
K
---
V
A
V
K
T
---------------E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
-
P
N
V
I
R
LLGV
C
I
-----------P-----
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
------
Y
S
R
----
L
-------
E
-----------
T
--------
G
--
P
K
---------
H
-------
I
P
---
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
--
M
T
V
C
V
A
D
F
G
L
S
---------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
-
R
G
M
T
P
Y
P
G
-
V
-
Q
-
N
H
E
-
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
---
Q
L
E
K
L
----
L
E
S
L
P
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
461
Blastp_CBE
46.88
37%
-88
- C2 -
-
4FEQ
6.7
-
A:
[22-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
Q
F
T
L
G
R
M
--
L
G
K
---
G
S
V
R
E
A
Q
-
L
---
K
-----
D
--
G
--
S
-
F
V
-
K
---
V
A
V
K
M
L
---------------
F
L
R
E
A
A
C
M
K
E
F
-
D
H
-
P
H
V
A
K
----
L
V
G
V
-
S
-------P-----
M
V
I
L
P
F
M
K
H
G
D
L
H
A
F
L
L
------
A
S
R
----
I
---------------------------------------------------
P
---
L
Q
T
L
V
R
F
M
V
D
I
A
C
G
M
E
Y
L
S
S
R
N
F
I
H
R
D
L
A
A
R
N
C
M
L
---
A
E
D
--
M
T
V
C
V
A
D
F
G
------------------------
V
K
W
L
A
L
E
S
L
A
D
N
L
Y
T
V
H
S
D
V
W
A
F
G
V
T
M
W
E
I
M
T
-
R
G
Q
T
P
Y
A
G
-
I
-
E
-
N
A
E
-
I
Y
N
Y
L
I
G
-------
G
N
R
L
K
Q
P
P
E
C
M
E
E
V
Y
D
L
M
Y
Q
C
W
S
A
D
P
K
Q
R
P
S
F
T
C
L
R
M
---
E
L
E
N
I
LGHL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
312
Blastp_CBE
46.80
41%
-1
- C2 -
-
5NWZ
7.8
-
FGFR4_HUMAN
A:
[13-298]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
W
-
E
F
P
R
D
R
L
V
L
G
K
P
--
L
G
E
G
C
F
G
Q
V
V
R
A
E
-
A
---
F
G
M
---
D
--
P
--
A
R
P
D
-
Q
AST
V
A
V
K
M
L
--
K
-
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
G
R
H
-
K
N
I
I
N
----
L
L
G
V
-
C
T
Q
E
-
G
P
L
------
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
------
A
R
R
----
P
PGPDL--------------------------------------P------
L
S
---
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
----------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
I
-
P
-
V
E
E
-
L
F
S
L
L
R
E
-------
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
---
A
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
552
Blastp_CBE
46.76
38%
3
- C2 -
-
6HET
10.3
-
A:
[19-289]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
R
Q
K
V
--
I
G
A
G
E
F
G
E
V
Y
K
G
M
-
L
KT------
E
V
--
P
-----------
V
A
I
K
T
L
--
K
-
A
G
Y
T
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
-
H
N
I
I
R
----
L
E
G
V
-
I
S
K
Y
-
K
P
M
------
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----------------------------------
K
--
D
G
---------
E
-------
F
S
---
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
---
N
--
L
V
C
K
V
S
D
F
G
L
----------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
G
E
R
P
Y
W
E
-
L
-
S
-
N
H
E
-
V
M
K
A
I
N
D
-------
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
---
I
L
D
K
L
----
I
R
A
-
P
D
S
L
K
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
396
Blastp_CBE
46.68
38%
-26
- C2 -
-
3BRB
4.1
-
B:
[31-312]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
I
L
G
K
I
--
L
G
E
G
E
F
G
S
V
M
E
G
N
-
L
---
K
--
Q
-
E
D
--
G
--
T
-
S
L
-
K
---
V
A
V
K
T
M
--
K
-
L
D
N
S
S
Q
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
-
P
N
V
I
R
LLGV
C
I
E
M
-
S
S
Q
G
-
I
P
K
P-----
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
------
Y
S
R
----
L
-------
E
-----------
T
--------
G
--
P
K
---------
H
-------
I
P
---
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
--
M
T
V
C
V
A
D
F
G
L
----------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
-
R
G
M
T
P
Y
P
G
-
V
-
Q
-
N
H
E
-
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
---
Q
L
E
K
L
----
L
E
S
L
P
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
387
Blastp_CBE
46.60
38%
-33
- C2 -
-
5K0K
6.8
-
MERTK_HUMAN
A:
[31-312]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
I
L
G
K
I
--
L
G
E
---
G
S
V
M
E
G
N
-
L
---
K
--
Q
-
E
D
--
G
--
T
-
S
L
-
K
---
V
A
V
K
T
M
--
K
-
L
D
N
S
S
Q
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
-
P
N
V
I
R
LLGV
C
I
E
--------
P
K
P-----
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
------
Y
S
R
----
L
-------
E
-----------
T
--------
G
--
P
K
---------
H
-------
I
P
---
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
--
M
T
V
C
V
A
D
F
G
L
----------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
-
R
G
M
T
P
Y
P
G
-
V
-
Q
-
N
H
E
-
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
---
Q
L
E
K
L
----
L
E
S
L
P
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
362
Blastp_CBE
46.58
37%
-10
- C2 -
-
5U6C
7.3
-
B:
[26-313]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
-
E
-
D
V
V
I
D
R
N
L
L
I
L
G
KI
L
G
E
---
G
S
V
M
E
G
N
-
L
---
K
--
Q
-
E
D
--
G
--
T
-
S
L
-
K
---
V
A
V
K
T
M
------------
I
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
-
P
N
V
M
R
LLGV
C
I
E
M
-
S
S
Q
G
-
I
P
K
P-----
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
------
Y
S
R
----
L
-------
E
-----------
T
--------
G
--
P
K
---------
H
-------
I
P
---
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
--
M
T
V
C
V
A
D
F
-----------------------
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
-
R
G
M
T
P
Y
P
G
-
V
-
Q
-
N
H
E
-
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
---
Q
L
E
K
L
----
L
E
S
L
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
397
Blastp_CBE
46.38
38%
-39
- C2 -
-
3BRB
4.4
-
MERTK_HUMAN
A:
[31-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
I
L
G
K
I
--
L
G
E
-
E
F
G
S
V
M
E
G
N
-
L
---
K
--
Q
-
E
D
--
G
--
T
-
S
L
-
K
---
V
A
V
K
T
M
------
N
S
S
Q
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
-
P
N
V
I
R
LLGV
C
I
E
---------
K
P-----
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
------
Y
S
R
----
L
-------
E
-----------
T
--------
G
--
P
K
---------
H
-------
I
P
---
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
--
M
T
V
C
V
A
D
F
G
L
S
--------------------
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
-
R
G
M
T
P
Y
P
G
-
V
-
Q
-
N
H
E
-
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
---
Q
L
E
K
L
----
L
E
S
L---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
267
Blastp_CBE
46.19
39%
-1
- C2 -
-
4F63
5.6
-
B:
[16-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
P
--
L
G
E
G
A
-
G
Q
V
V
L
A
E
-
A
---
I
G
L
------
P
--
N
-
R
V
T
K
---
V
A
V
K
M
L
--
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
-
K
N
I
I
N
----
L
L
G
A
-
C
T
Q
D
-
G
P
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
------
A
R
R
-----------------------------------------------
Q
-------
L
S
---
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
A
---------
D
Y
Y
K
-
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
V
-
P
-
V
E
E
-
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
---
D
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
210
Blastp_CBE
46.18
41%
-3
- C2 -
-
5JKG
6.9
-
A:
[17-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
W
-
E
F
P
R
D
R
L
V
L
G
K
P
--
L
G
E
G
A
F
G
Q
V
V
R
A
E
-
A
---
F
G
M
---
D
--
P
--
A
R
P
D
-
Q
AST
V
A
V
K
M
L
--
K
-
D
---
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
G
R
H
-
K
N
I
I
N
----
L
L
G
V
-
C
T
Q
E
-
G
P
L
------
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
------
A
R
R
----
P
PGP----------------------------------------P------
L
S
---
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
---------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
I
-
P
-
V
E
E
-
L
F
S
L
L
R
E
-------
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
---
A
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
393
Blastp_CBE
45.56
38%
-54
- C2 -
-
4M3Q
5.2
-
MERTK_HUMAN
A:
[31-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
I
L
G
K
I
--
L
G
E
G
E
F
G
S
V
M
E
G
N
-
L
---
K
--
Q
-
E
D
--
G
--
T
-
S
L
-
K
---
V
A
V
K
T
----------------------
C
M
K
D
F
-
S
H
-
P
N
V
I
R
LLGV
C
I
E
M
-
S
S
Q
G
-
I
P
K
P-----
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
------
Y
S
R
----
L
-------
E
-----------
T
--------
G
--
P
K
---------
H
-------
I
P
---
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
--
M
T
V
C
V
A
D
F
------------------------
P
V
K
W
I
A
I
E
S
L
--
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
-
R
G
M
T
P
Y
P
G
-
V
-
Q
-
N
H
E
-
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
---
Q
L
E
K
L
----
L
E
S
L---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
401
Blastp_CBE
45.41
38%
-37
- C2 -
-
3BPR
5.3
-
MERTK_HUMAN
A:
[31-312]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
I
L
G
K
I
--
L
G
E
G
E
F
G
S
V
M
E
G
N
-
L
---
K
--
Q
-
E
D
--
G
--
T
-
S
L
-
K
---
V
A
V
K
T
M
--
K
-------
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
-
P
N
V
I
R
LLGV
C
I
E
M
-
S
S
------P-----
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
------
Y
S
R
----
L
-------
E
-----------
T
--------
G
--
P
K
---------
H
-------
I
P
---
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
--
M
T
V
C
V
A
D
F
G
L
S
---------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
-
R
G
M
T
P
Y
P
G
-
V
-
Q
-
N
H
E
-
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
---
Q
L
E
K
L
----
L
E
S
L
P
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
208
Blastp_CBE
45.16
40%
-9
- C2 -
-
5XFJ
6.8
-
A:
[14-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
P
L
-
W
-
E
F
P
R
D
R
L
V
L
G
K
P
--
L
G
E
G
A
F
G
Q
V
V
R
A
E
-
A
---
F
G
M
---
D
--
P
--
A
R
P
D
-
Q
AST
V
A
V
K
M
L
--
K
-
D
---
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
G
R
H
-
K
N
I
I
N
----
L
L
G
V
-
C
T
Q
E
-
G
P
L
------
Y
V
I
M
E
C
A
A
K
G
N
L
R
E
F
L
R
------
A
R
R
----
P
PGP----------------------------------------P------
L
S
---
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
---------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
I
-
P
-
V
E
E
-
L
F
S
L
L
R
E
-------
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
---
A
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
205
Blastp_CBE
45.05
41%
-9
- C2 -
-
5XFF
7.2
-
A:
[14-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
P
L
-
W
-
E
F
P
R
D
R
L
V
L
G
K
P
--
L
G
E
G
A
F
G
Q
V
V
R
A
E
-
A
---
F
G
M
---
D
--
P
--
A
R
P
D
-
Q
AST
V
A
V
K
M
L
--
K
-
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
G
R
H
-
K
N
I
I
N
----
L
L
G
V
-
C
T
Q
E
-
G
P
L
------
Y
V
I
L
E
C
A
A
K
G
N
L
R
E
F
L
R
------
A
R
R
----
P
PGP----------------------------------------P------
L
S
---
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
--
N
V
M
K
I
A
D
F
G
L
---------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
-
I
-
P
-
V
E
E
-
L
F
S
L
L
R
E
-------
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
---
A
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
389
Blastp_CBE
44.84
38%
-32
- C2 -
-
4MHA
5.0
-
MERTK_HUMAN
A:
[31-312]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
I
L
G
K
I
--
L
G
E
---
G
S
V
M
E
G
N
-
L
---
K
--
Q
-
E
D
--
G
--
T
-
S
L
-
K
---
V
A
V
K
T
M
--
K
-
L
D
N
S
S
Q
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
-
P
N
V
I
R
LLGV
C
I
E
--------
P
K
P-----
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
------
Y
S
R
----
L
-------
E
-----------
T
--------
G
--
P
K
---------
H
-------
I
P
---
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
--
M
T
V
C
V
A
D
F
G
-----------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
-
R
G
M
T
P
Y
P
G
-
V
-
Q
-
N
H
E
-
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
---
Q
L
E
K
L
----
L
E
S
L
P
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
395
Blastp_CBE
44.55
38%
-32
- C2 -
-
3TCP
6.3
-
MERTK_HUMAN
A:
[31-312]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
I
L
G
K
I
--
L
-----
G
S
V
M
E
G
N
-
L
---
K
--
Q
-
E
D
--
G
--
T
-
S
L
-
K
---
V
A
V
K
T
M
--
K
-
L
D
N
S
S
Q
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
-
P
N
V
I
R
LLGV
C
I
E
--------
P
K
P-----
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
------
Y
S
R
----
L
-------
E
-----------
T
--------
G
--
P
K
---------
H
-------
I
P
---
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
--
M
T
V
C
V
A
D
F
------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
-
R
G
M
T
P
Y
P
G
-
V
-
Q
-
N
H
E
-
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
---
Q
L
E
K
L
----
L
E
S
L
P
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
403
Blastp_CBE
44.25
38%
-42
- C2 -
-
2P0C
4.1
-
MERTK_HUMAN
A:
[31-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
I
L
G
K
I
--
L
--
G
E
F
G
S
V
M
E
G
N
-
L
---
K
--
Q
-
E
D
--
G
--
T
-
S
L
-
K
---
V
A
V
K
T
M
--------------E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
-
P
N
V
I
R
LLGV
C
---------
I
P
K
P-----
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
------
Y
S
R
----
L
-------
E
-----------
T
--------
G
--
P
K
---------
H
-------
I
P
---
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
--
M
T
V
C
V
A
D
F
G
L
----------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
-
R
G
M
T
P
Y
P
G
-
V
-
Q
-
N
H
E
-
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
---
Q
L
E
K
L
----
L
E
S
L---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
402
Blastp_CBE
44.14
38%
-38
- C2 -
-
2P0C
3.5
-
B:
[31-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
I
L
G
K
I
--
L
G
E
---
G
S
V
M
E
G
N
-
L
---
K
--
Q
-
E
D
--
G
--
T
-
S
L
-
K
---
V
A
V
K
T
M
--------------E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
-
P
N
V
I
R
LLGV
C
---------
I
P
K
P-----
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
------
Y
S
R
----
L
-------
E
-----------
T
--------
G
--
P
K
---------
H
-------
I
P
---
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
--
M
T
V
C
V
A
D
F
G
L
----------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
-
R
G
M
T
P
Y
P
G
-
V
-
Q
-
N
H
E
-
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
---
Q
L
E
K
L
----
L
E
S
L---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
450
Blastp_CBE
43.65
38%
-60
- C2 -
-
5TD2
6.3
-
MERTK_HUMAN
A:
[6-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
I
L
G
K
I
--
L
G
E
G
E
F
G
S
V
M
E
G
N
-
L
---
K
--
Q
-
E
D
--
G
--
T
-
S
L
-
K
---
V
A
V
K
T
M
-------------------
A
A
C
M
K
D
F
-
S
H
-
P
N
V
M
R
LLGV
C
I
E
M
-
S
S
------P-----
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
------
Y
S
R
----
L
-------
E
-----------
T
--------
G
--
P
K
---------
H
-------
I
P
---
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
--
M
T
V
C
V
A
D
F
------------------------
P
V
K
W
I
A
I
E
S
L
----
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
-
R
G
M
T
P
Y
P
G
-
V
-
Q
-
N
H
E
-
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
---
Q
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
412
Blastp_CBE
42.29
38%
-43
- C2 -
-
5TC0
6.3
-
MERTK_HUMAN
A:
[32-311]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
I
L
G
K
I
--
L
G
E
G
E
F
G
S
V
M
E
G
N
-
L
---
K
--
Q
-
E
D
--
G
--
T
-
S
L
-
K
---
V
A
V
K
T
M
-----------------------
K
D
F
-
S
H
-
P
N
V
M
R
LLGV
C
I
E
M
-
S
S
Q
G
-
I
P
K
P-----
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
------
Y
S
R
----
L
-------
E
-----------
T
--------
G
--
P
K
---------
H
-------
I
P
---
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
--
M
T
V
C
V
A
D
F
-----------------------
M
P
V
K
W
I
A
I
E
-------
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
-
R
G
M
T
P
Y
P
G
-
V
-
Q
-
N
H
E
-
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
---
Q
L
E
K
L
----
L
E
S
L---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
384
Blastp_CBE
41.96
38%
-28
- C2 -
-
5K0X
5.7
-
B:
[31-312]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
I
L
G
K
I
--
L
--
G
E
F
G
S
V
M
E
G
N
-
L
---
K
--
Q
-
E
D
--
G
--
T
-
S
L
-
K
---
V
A
V
K
T
---------------E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
-
P
N
V
I
R
LLGV
C
I
E
M
-
S
S
Q
G
-
I
P
K
P-----
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
------
Y
S
R
----
L
-------
E
-----------
T
--------
G
--
P
K
---------
H
-------
I
P
---
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
--
M
T
V
C
V
A
D
-------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
-
R
G
M
T
P
Y
P
G
-
V
-
Q
-
N
H
E
-
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
---
Q
L
E
K
L
----
L
E
S
L
P
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------