@TOME V3
(Feb 2022)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Screening
Virtual Screening Score
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ARAF_HUMAN: (2020-09-04 )
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCVVYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLFHGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSVQDLSGGSRQHEAPSNRPLNELLTPQGPSPRTQHCDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSNLIQLTGQSFSTDAAGSRGGSDGTPRGSPSPASVSSGRKSPHSKSPAEQRERKSLADDKKKVKNLGYRDSGYYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP
Atome Classification :
(188 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320..------.....--330----.--------.------.......340....-...350.......360........370.-..--.--..---..380.......390..-------..-..-.--400--------.---------------........410.......420-.---..---.....430.......440------..-......450-------..--......460-........470.......480..----.....490.......500..-.....510....-...520.....--.--..530-....--...540.......550.......560......-.570.......580......---.590.......600....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(pKd)
(pKd)
(Uniprot)
MEPPRGPPANGAEPSR
A
V
G
T
V
K
V
Y
LPNK
Q
R
T
V
V
T
VRD
G
M
S
V
Y
D
S
L
D
K
A
L
K
VRGL
N
Q
D
C
C
V
V
Y
R
L
IKGR
K
T
V
T
AWDTAIAPLD
G
E
E
L
I
V
E
V
L
E
DV
P
L
T
M
H
N
F
V
R
K
T
F
F
S
L
A
F
C
D
F
C
L
K
F
L
FHG
F
R
CQTCG
Y
K
F
H
Q
H
CSSKV
P
T
V
C
V
DMST
N
R
Q
Q
F
Y
H
S
V
Q
DLSGGSRQHEAPSNRP
L
N
E
LLTPQGPSPRTQHCDPEHFPFPAPAN
A
P
L
Q
R
I
RSTSTP
N
V
H
M
V
S
TTAPMDS
N
L
I
Q
LTGQSFSTDAAGSRGGSDGTPRGSPSPASVSSGRKSPHSKS
P
A
E
Q
R
E
R
K
S
LAD
D
K
K
K
V
K
NLGYRDS
G
Y
Y
W
EV
P
P
S
E
V
Q
L
L
K
R
IGTGSFG
T
V
------
F
RGRW--H------G--------
D
------
V
A
V
K
V
L
KVSQP
T
A
E
-
Q
A
Q
A
F
K
N
E
M
Q
V
L
R
KT-RH
V
N
I
L
L
F
MG-F-MT--R--P
G
---
F
A
I
I
T
Q
WCEGS
S
L
Y
H
H
L
-------
H
V-AD-
T
--
R
----------
F
---------------
D
M
V
Q
L
I
D
V
A
R
Q
T
AQG
M
D
Y
L
H
--
A
---
K
N
---
I
I
H
R
DLKSN
N
I
F
L
HE
G
L
-------
T
V
-
K
IGDF
G
L
A
--------
T
V
--
K
TRWSGAQ--PLEQPSG
S
V
L
W
M
A
A
E
V
I
RMQDPN----PYS
F
Q
S
D
V
Y
A
Y
G
V
V
L
Y
E
L
M
T-GSLPYSHIGCR
D
-
Q
I
I
F
M
-VGRGY--L--SP
D
L
S
-
K
I
SS--N
C
P
K
A
M
R
R
L
L
S
D
C
L
K
F
Q
REERP
L
F
P
Q
I
L
A
T
I
E
-
L
L
Q
R
S
L
P
K
I
E
RSASEPSLHR---
T
Q
A
D
E
L
P
A
C
L
L
S
A
ARLVP
547
HHSearch
92.03
60%
-114
- C3 -
-
6NYB
4.9
-
?
A:
[260-762]
------------------------------------------------------------------------------------------------
T
T
H
N
F
V
R
K
T
F
F
T
L
A
F
C
D
F
C
R
K
L
L
F
Q
G
F
R
C
Q
T
C
G
Y
K
F
H
Q
R
C
S
T
E
V
P
L
M
C
V
---------------------------------------------------------------
R
D
R
S
S
S
A
P
N
V
H
----------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
--
K
S
R
W
S
G
S
H
--
Q
F
E
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
I
H
R
S
A
S
E
P
S
L
N
R
---------------------
4
PsiBlast_PDB
91.69
58%
-114
- C3 -
-
6NYB
4.9
-
?
A:
[260-765]
------------------------------------------------------------------------------------------------
T
T
H
N
F
V
R
K
T
F
F
T
L
A
F
C
D
F
C
R
K
L
L
F
Q
G
F
R
C
Q
T
C
G
Y
K
F
H
Q
R
C
S
T
E
V
P
L
M
C
V
---------------------------------------------------------------
R
D
R
S
S
S
A
P
N
V
H
----------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
--
K
S
R
W
S
G
S
H
--
Q
F
E
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
I
H
R
S
A
S
E
P
S
L
N
R
AGF------------------
550
HHSearch
87.00
77%
-134
- C3 -
-
4H58
-
-
C:
[3-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
--
K
S
R
W
S
G
S
H
--
Q
F
E
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
--
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
----------------------------------
549
HHSearch
86.87
73%
-123
- C3 -
-
6U2H
8.0
-
D:
[3-288]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
A
-
S
E
-
T
--
K
----------
F
---------------
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
--
K
S
R
W
S
G
S
-----
E
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
S
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
-
V
G
R
G
S
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
E
L
P
K
I
H
R
S
A
S
E
P
S
L
-----------------------
95
Blastp_CBE
86.61
73%
-123
- C3 -
-
6U2H
8.0
-
D:
[5-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
A
-
S
E
-
T
--
K
----------
F
---------------
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
--
K
S
R
W
S
G
S
-----
E
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
S
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
-
V
G
R
G
S
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
E
L
P
K
I
H
R
S
A
-
E
P
S
L
N
----------------------
73
Blastp_CBE
86.56
76%
-125
- C3 -
-
6PP9
6.8
-
?
A:
[7-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
--
K
S
R
W
S
G
S
H
--
Q
F
E
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
----------------------------------
28
Blastp_CBE
86.14
74%
-131
- C3 -
-
4EHE
8.0
-
B:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
--
K
S
R
W
S
G
S
H
--
Q
F
E
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
---------------------------------
58
Blastp_CBE
85.80
74%
-145
- C3 -
-
4MBJ
5.1
-
BRAF_HUMAN
A:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
--
K
S
R
W
S
---------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
---------------------------------
46
Blastp_CBE
85.61
74%
-129
- C3 -
-
4MNE
-
-
BRAF_HUMAN
B:
[30-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
----
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
--
K
S
R
W
S
G
S
H
--
Q
F
E
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
----------------------------------
91
Blastp_CBE
85.53
76%
-141
- C3 -
-
6N0P
10.7
-
B:
[2-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
---------------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
--
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
-----------------------------------
32
Blastp_CBE
85.49
74%
-134
- C3 -
-
3TV6
8.4
-
B:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
--
K
S
R
W
S
G
S
H
--
Q
F
E
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
---------------------------------
553
HHSearch
85.27
76%
-141
- C3 -
-
6N0Q
9.5
-
?
B:
[7-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
-----------------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
---
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
-----------------------------------
83
Blastp_CBE
85.19
76%
-142
- C3 -
-
5CT7
11.6
-
BRAF_HUMAN
A:
[7-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
----------------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
-----------------------------------
74
Blastp_CBE
85.18
76%
-141
- C3 -
-
6N0Q
9.5
-
?
B:
[6-279]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
-----------------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
---
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
-----------------------------------
79
Blastp_CBE
85.15
76%
-125
- C3 -
-
5VAM
11.5
-
BRAF_HUMAN
A:
[7-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
--
K
S
R
W
S
------
F
E
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
-----------------------------------
19
PsiBlast_PDB
85.10
74%
-132
- C3 -
-
4E26
5.1
-
BRAF_HUMAN
A:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
--
K
S
R
--------
F
E
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
---------------------------------
88
Blastp_CBE
84.97
77%
-142
- C3 -
-
4H58
7.5
-
BRAF_HUMAN
A:
[3-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
--
K
--------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
----------------------------------
551
HHSearch
84.94
76%
-141
- C3 -
-
6N0P
10.7
-
B:
[2-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
---------------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
--
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
-------------------------------------
57
Blastp_CBE
84.92
74%
-135
- C3 -
-
4MBJ
7.0
-
B:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
--
K
S
R
W
S
G
S
H
--
Q
F
E
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
---------------------------------
66
Blastp_CBE
84.89
76%
-140
- C3 -
-
4KSQ
10.0
-
BRAF_HUMAN
A:
[6-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
-----------------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
----------------------------------
68
Blastp_CBE
84.77
76%
-140
- C3 -
-
4KSP
9.8
-
BRAF_HUMAN
A:
[6-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
------------------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
----------------------------------
22
Blastp_CBE
84.74
77%
-142
- C3 -
-
3OMV
6.5
-
B:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Y
W
E
I
E
A
S
E
V
M
L
S
T
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
I
L
K
V
V
D
P
T
P
E
-
Q
F
Q
A
F
R
N
E
V
A
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
M
T
--
K
--
D
N
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
K
H
L
-------
H
V
-
Q
E
-
T
--
K
----------
F
---------------
Q
M
F
Q
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
N
---
I
I
H
R
D
M
K
S
N
N
I
F
L
H
E
G
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
----------------
P
T
G
S
V
L
W
M
A
P
E
V
I
R
M
Q
D
N
N
----
P
F
S
F
Q
S
D
V
Y
S
Y
G
I
V
L
Y
E
L
M
T
-
G
E
L
P
Y
S
H
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
A
--
S
P
D
L
S
-
K
L
Y
K
--
N
C
P
K
A
M
K
R
L
V
A
D
C
V
K
K
V
K
E
E
R
P
L
F
P
Q
I
L
S
S
I
E
-
L
L
Q
H
S
L
P
K
---------------------------------
33
Blastp_CBE
84.72
74%
-133
- C3 -
-
3TV4
7.5
-
B:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
--
K
S
R
W
S
G
S
H
--
Q
F
E
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
---------------------------------
20
PsiBlast_PDB
84.72
74%
-144
- C3 -
-
4E4X
9.6
-
BRAF_HUMAN
A:
[29-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
--
K
S
R
W
S
---------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
-----------------------------------
69
Blastp_CBE
84.68
76%
-138
- C3 -
-
4FC0
9.9
-
B:
[6-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
--
K
S
R
W
------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
------------------------------------
85
Blastp_CBE
84.60
76%
-143
- C3 -
-
2FB8
8.3
-
BRAF_HUMAN
A:
[7-278]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
-----------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
------------------------------------
14
PsiBlast_PDB
84.51
74%
-137
- C3 -
-
3Q4C
7.9
-
BRAF_HUMAN
A:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
--
K
--------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
---------------------------------
97
Blastp_CBE
84.43
73%
-135
- C3 -
-
4XV9
10.0
-
A:
[17-290]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
A
-
S
E
-
T
--
K
----------
F
---------------
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-------
T
V
-
K
I
G
D
F
G
L
A
--------------------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
S
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
-
V
G
R
G
S
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
E
L
-----------------------------------
75
Blastp_CBE
84.38
76%
-136
- C3 -
-
6N0Q
9.8
-
?
A:
[4-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
-----------------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
--
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
-----------------------------------
78
Blastp_CBE
84.36
76%
-140
- C3 -
-
5VAM
11.4
-
B:
[7-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------------
R
W
-----------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
-----------------------------------
7
PsiBlast_PDB
84.32
76%
-140
- C3 -
-
3OMV
4.4
-
RAF1_HUMAN
A:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Y
W
E
I
E
A
S
E
V
M
L
S
T
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
I
L
K
V
V
D
P
T
P
E
-
Q
F
Q
A
F
R
N
E
V
A
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
M
T
--
K
--
D
N
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
K
H
L
-------
H
V
-
Q
E
-
T
--
K
----------
F
---------------
Q
M
F
Q
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
N
---
I
I
H
R
D
M
K
S
N
N
I
F
L
H
E
G
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
----------------
P
T
G
S
V
L
W
M
A
P
E
V
I
R
M
Q
D
N
N
----
P
F
S
F
Q
S
D
V
Y
S
Y
G
I
V
L
Y
E
L
M
T
-
G
E
L
P
Y
S
H
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
A
--
S
P
D
L
S
-
K
L
Y
K
--
N
C
P
K
A
M
K
R
L
V
A
D
C
V
K
K
V
K
E
E
R
P
L
F
P
Q
I
L
S
S
I
E
-
L
L
Q
H
S
L
P
K
---------------------------------
25
Blastp_CBE
84.21
74%
-136
- C3 -
-
4PP7
9.0
-
BRAF_HUMAN
A:
[29-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
--
K
S
R
W
S
---------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
-----------------------------------
24
Blastp_CBE
84.17
74%
-132
- C3 -
-
4PP7
9.0
-
B:
[29-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
--
K
S
R
W
S
G
S
H
--
Q
F
E
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
-----------------------------------
18
PsiBlast_PDB
84.15
74%
-138
- C3 -
-
3TV6
8.3
-
BRAF_HUMAN
A:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
--
K
S
R
W
S
----------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
---------------------------------
34
Blastp_CBE
84.12
74%
-126
- C3 -
-
3SKC
9.2
-
B:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
--
K
S
R
W
S
G
S
H
--
Q
F
E
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
---------------------------------
27
Blastp_CBE
84.10
74%
-137
- C3 -
-
4G9C
9.5
-
BRAF_HUMAN
A:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
--
K
-------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
---------------------------------
81
Blastp_CBE
84.09
76%
-133
- C3 -
-
5VAL
10.6
-
BRAF_HUMAN
A:
[4-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
-------------------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
--
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
------------------------------------
96
Blastp_CBE
84.08
73%
-129
- C3 -
-
6U2H
7.8
-
BRAF_HUMAN
C:
[5-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
A
-
S
E
-
T
--
K
----------
F
---------------
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
--
K
S
R
-------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
S
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
-
V
G
R
G
S
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
E
L
P
K
I
H
R
S
A
-
E
P
S
L
N
----------------------
23
Blastp_CBE
84.06
74%
-129
- C3 -
-
6U2G
5.4
-
MP2K1_HUMAN
B:
[32-303]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
--
K
S
----------
E
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
----------------------------------
82
Blastp_CBE
83.99
76%
-141
- C3 -
-
5CT7
11.5
-
B:
[7-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
-------------------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
-----------------------------------
104
Blastp_CBE
83.94
73%
-120
- C3 -
-
6NSQ
9.9
-
BRAF_HUMAN
A:
[9-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
A
-
S
E
-
T
--
K
----------
F
---------------
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
--
K
S
R
W
S
-
S
H
--
Q
F
E
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
S
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
-
V
G
R
G
S
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
E
L
-----------------------------------
71
Blastp_CBE
83.94
76%
-123
- C3 -
-
4DBN
10.7
-
B:
[6-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
--
K
S
R
W
------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
------------------------------------
67
Blastp_CBE
83.91
76%
-139
- C3 -
-
4KSP
10.8
-
B:
[6-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
-----------------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
------------------------------------
30
Blastp_CBE
83.91
74%
-133
- C3 -
-
4E4X
9.3
-
B:
[29-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
--
K
S
R
W
S
G
S
H
--
Q
F
E
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
-----------------------------------
65
Blastp_CBE
83.88
76%
-140
- C3 -
-
4KSQ
10.5
-
B:
[7-278]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
-----------------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
------------------------------------
80
Blastp_CBE
83.83
76%
-137
- C3 -
-
5VAL
10.8
-
B:
[6-279]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
-----------------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
---
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
-----------------------------------
17
PsiBlast_PDB
83.74
74%
-138
- C3 -
-
3TV4
7.6
-
BRAF_HUMAN
A:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
--
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
--
K
S
R
------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
---------------------------------
77
Blastp_CBE
83.67
76%
-139
- C3 -
-
6B8U
10.9
-
BRAF_HUMAN
A:
[7-278]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
----------------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
---
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
------------------------------------
41
Blastp_CBE
83.58
74%
-134
- C3 -
-
3D4Q
6.6
-
B:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
----------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
---------------------------------
122
Blastp_CBE
83.52
72%
-129
- C3 -
-
4RZV
11.0
-
B:
[7-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
H
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
A
-
S
E
-
T
--
K
----------
F
---------------
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
--
K
S
R
W
S
G
S
H
--
Q
F
E
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
-------
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
-
V
G
R
G
S
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
E
L
-----------------------------------
63
Blastp_CBE
83.51
77%
-136
- C3 -
-
3Q96
11.7
-
B:
[5-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
--
K
S
R
W
------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
------------------------------------
11
PsiBlast_PDB
83.51
74%
-141
- C3 -
-
3PPK
9.0
-
BRAF_HUMAN
A:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
---------------------------------
12
PsiBlast_PDB
83.46
74%
-142
- C3 -
-
3PRF
8.3
-
BRAF_HUMAN
A:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
---------------------------------
31
Blastp_CBE
83.40
74%
-138
- C3 -
-
4E26
3.7
-
B:
[29-303]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
--
K
S
-------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
----------------------------------
70
Blastp_CBE
83.39
76%
-139
- C3 -
-
4FC0
9.5
-
BRAF_HUMAN
A:
[6-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
------------------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
---
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
----------------------------------
139
Blastp_CBE
83.29
72%
-130
- C3 -
-
5HID
10.7
-
B:
[14-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
-----
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
A
-
S
E
-
T
--
K
----------
F
---------------
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
--
K
S
R
W
S
G
S
H
--
Q
F
E
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
S
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
-
V
G
R
G
S
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
E
L
-----------------------------------
29
Blastp_CBE
83.29
74%
-137
- C3 -
-
4EHE
7.7
-
BRAF_HUMAN
A:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
--
K
S
R
------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
---------------------------------
59
Blastp_CBE
83.21
74%
-145
- C3 -
-
5HIE
11.2
-
D:
[30-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
-----
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
----------------------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
----------------------------------
123
Blastp_CBE
83.16
72%
-143
- C3 -
-
4RZV
11.1
-
BRAF_HUMAN
A:
[7-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
H
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
A
-
S
E
-
T
--
K
----------
F
---------------
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
----------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
S
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
-
V
G
R
G
S
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
E
L
-----------------------------------
48
Blastp_CBE
83.15
74%
-135
- C3 -
-
5FD2
8.7
-
BRAF_HUMAN
A:
[22-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
--
K
S
R
W
-----------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
------------------------------------
84
Blastp_CBE
83.11
76%
-135
- C3 -
-
2FB8
7.9
-
B:
[7-278]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
-----------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
------------------------------------
61
Blastp_CBE
83.11
74%
-149
- C3 -
-
5HIE
11.2
-
BRAF_HUMAN
B:
[30-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
-----
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
--
K
S
R
------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
----------------------------------
26
Blastp_CBE
83.08
74%
-138
- C3 -
-
4G9C
9.9
-
B:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
----------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
---------------------------------
125
Blastp_CBE
83.03
73%
-150
- C3 -
-
5ITA
9.6
-
B:
[24-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
---
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
A
-
S
E
-
T
--
K
----------
F
---------------
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-------
T
V
-
K
I
G
D
F
------------------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
-
S
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
-
V
G
R
G
S
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
E
L
-----------------------------------
115
Blastp_CBE
82.94
73%
-134
- C3 -
-
4WO5
9.5
-
BRAF_HUMAN
A:
[25-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
A
-
S
E
----
K
----------
F
---------------
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
--
K
S
R
W
S
------
F
E
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
---
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
-
V
G
R
G
S
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
E
L
-----------------------------------
8
PsiBlast_PDB
82.94
74%
-134
- C3 -
-
3D4Q
7.2
-
BRAF_HUMAN
A:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
----------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
---------------------------------
9
PsiBlast_PDB
82.92
74%
-135
- C3 -
-
3PSB
7.5
-
BRAF_HUMAN
A:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
---------------------------------
72
Blastp_CBE
82.91
76%
-134
- C3 -
-
4DBN
10.3
-
BRAF_HUMAN
A:
[6-279]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
-----------------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
-----------------------------------
21
Blastp_CBE
82.83
73%
-140
- C3 -
-
4MNF
7.7
-
B:
[42-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
E
-------------------
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
------------------------------------
93
Blastp_CBE
82.74
76%
-136
- C3 -
-
4YHT
8.1
-
B:
[2-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
T
-
N
E
-
T
--
K
----------
F
---------------
E
M
T
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
--
K
--------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
------
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
T
F
P
Q
I
L
A
S
I
E
-
T
L
A
R
S
------------------------------------
43
Blastp_CBE
82.74
74%
-134
- C3 -
-
3II5
10.4
-
BRAF_HUMAN
A:
[28-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
---------------
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
------------------------------------
16
PsiBlast_PDB
82.61
74%
-138
- C3 -
-
3SKC
8.6
-
BRAF_HUMAN
A:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
----------------------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
---------------------------------
39
Blastp_CBE
82.60
74%
-134
- C3 -
-
3PPK
8.5
-
B:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
----------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
---------------------------------
87
Blastp_CBE
82.58
77%
-137
- C3 -
-
1UWH
9.1
-
BRAF_HUMAN
A:
[3-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
A
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
----------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
---------------------------------
76
Blastp_CBE
82.53
76%
-139
- C3 -
-
6B8U
10.7
-
B:
[5-278]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
----
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
-------------------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
---
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
------------------------------------
92
Blastp_CBE
82.51
76%
-127
- C3 -
-
6N0P
9.6
-
BRAF_HUMAN
A:
[2-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
--
K
S
R
W
S
-------
E
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
-----------------------------------
55
Blastp_CBE
82.51
74%
-140
- C3 -
-
4EHG
8.2
-
B:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
----------------------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
---------------------------------
49
Blastp_CBE
82.51
74%
-137
- C3 -
-
3IDP
10.7
-
B:
[22-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
----------------------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
------------------------------------
42
Blastp_CBE
82.50
74%
-140
- C3 -
-
3II5
10.1
-
B:
[29-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
----------------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
-----------------------------------
40
Blastp_CBE
82.50
74%
-134
- C3 -
-
3PPJ
7.5
-
B:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
----------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
---------------------------------
62
Blastp_CBE
82.47
74%
-144
- C3 -
-
5HIE
11.2
-
BRAF_HUMAN
A:
[30-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
-----
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
--
K
S
R
-------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
----------------------------------
557
HHSearch
82.45
73%
-149
- C3 -
-
5ITA
9.6
-
B:
[24-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
---
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
A
-
S
E
-
T
--
K
----------
F
---------------
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-------
T
V
-
K
I
G
D
F
------------------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
-
S
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
-
V
G
R
G
S
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
E
------------------------------------
38
Blastp_CBE
82.43
74%
-137
- C3 -
-
3PRF
7.4
-
B:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
---------------------------------
99
Blastp_CBE
82.39
73%
-134
- C3 -
-
5CSW
10.2
-
B:
[6-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
A
-
S
E
-
T
--
K
----------
F
---------------
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-------
T
V
-
K
I
G
D
F
G
L
------------------------------
S
I
L
W
M
A
P
E
V
I
R
---------
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
-
V
G
R
G
S
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
E
L
-----------------------------------
98
Blastp_CBE
82.36
73%
-131
- C3 -
-
5CSX
10.4
-
A:
[7-279]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
A
-
S
E
-
T
--
K
----------
F
---------------
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
--
K
S
R
------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
------
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
-
V
G
R
G
S
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
E
------------------------------------
94
Blastp_CBE
82.28
76%
-133
- C3 -
-
4YHT
7.6
-
BRAF_HUMAN
A:
[2-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
T
-
N
E
-
T
--
K
----------
F
---------------
E
M
T
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
--
K
---------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
------
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
T
F
P
Q
I
L
A
S
I
E
-
T
L
A
R
-------------------------------------
6
PsiBlast_PDB
82.26
73%
-136
- C3 -
-
4MNF
7.2
-
BRAF_HUMAN
A:
[42-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
E
-------------------
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
------------------------------------
15
PsiBlast_PDB
82.22
74%
-137
- C3 -
-
3PSD
8.3
-
BRAF_HUMAN
A:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
---------------------------------
50
Blastp_CBE
82.19
74%
-138
- C3 -
-
3IDP
10.9
-
BRAF_HUMAN
A:
[22-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
-------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
--
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
------------------------------------
35
Blastp_CBE
82.15
74%
-133
- C3 -
-
3PSD
8.1
-
B:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
----------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
---------------------------------
126
Blastp_CBE
82.14
73%
-141
- C3 -
-
5ITA
9.6
-
BRAF_HUMAN
A:
[24-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
A
-
S
E
-
T
--
K
----------
F
---------------
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-------
T
V
-
K
I
G
D
F
G
L
------------------------------
S
I
L
W
M
A
P
E
V
I
R
M
---
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
-
V
G
R
G
S
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
--------------------------------------
64
Blastp_CBE
82.01
77%
-143
- C3 -
-
3Q96
11.5
-
BRAF_HUMAN
A:
[5-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
------------------------------
S
I
L
W
M
A
P
E
V
I
R
M
---
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
----------------------------------
117
Blastp_CBE
81.99
72%
-139
- C3 -
-
4XV2
10.9
-
B:
[17-289]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
A
-
S
E
---------------
F
---------------
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-------
T
V
-
K
I
G
D
F
G
------------------------------
G
S
I
L
W
M
A
P
E
V
I
R
----
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
-
V
G
R
G
S
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
E
------------------------------------
134
Blastp_CBE
81.96
73%
-131
- C3 -
-
5JSM
9.5
-
BRAF_HUMAN
A:
[7-278]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
A
-
S
E
-
T
--
K
----------
F
---------------
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
E
--
K
--------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
S
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
-
V
G
R
G
S
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
E
L
-----------------------------------
121
Blastp_CBE
81.96
72%
-136
- C3 -
-
4RZW
9.0
-
BRAF_HUMAN
A:
[6-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
H
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
A
-
S
E
-
T
--
K
----------
F
---------------
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-------
T
V
-
K
I
G
D
F
G
------------------------------
G
S
I
L
W
M
A
P
E
V
I
R
----
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
-
V
G
R
G
S
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
E
------------------------------------
36
Blastp_CBE
81.94
74%
-132
- C3 -
-
3PSB
7.7
-
B:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
----------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
---------------------------------
109
Blastp_CBE
81.93
73%
-136
- C3 -
-
4JVG
9.1
-
BRAF_HUMAN
B:
[9-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
A
-
S
E
-
T
--
K
----------
F
---------------
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
--------------------
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
S
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
-
V
G
R
G
S
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
E
L
-----------------------------------
60
Blastp_CBE
81.90
74%
-141
- C3 -
-
5HIE
11.0
-
BRAF_HUMAN
C:
[30-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
-----
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
----------------------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
----------------------------------
56
Blastp_CBE
81.90
74%
-135
- C3 -
-
4EHG
7.5
-
BRAF_HUMAN
A:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
E
------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
---------------------------------
52
Blastp_CBE
81.89
74%
-141
- C3 -
-
5C9C
9.9
-
BRAF_HUMAN
A:
[30-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
--
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
--------------------
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
------------------------------------
10
PsiBlast_PDB
81.84
74%
-133
- C3 -
-
3PPJ
7.6
-
BRAF_HUMAN
A:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
---------------------------------
51
Blastp_CBE
81.77
74%
-143
- C3 -
-
5C9C
9.8
-
B:
[30-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
------------------------------
S
I
L
W
M
A
P
E
V
I
R
M
---
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
------------------------------------
107
Blastp_CBE
81.68
73%
-130
- C3 -
-
4JVG
8.6
-
D:
[9-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
A
-
S
E
-
T
--
K
----------
F
---------------
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
--
K
S
---------------
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
S
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
-
V
G
R
G
S
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
E
L
-----------------------------------
100
Blastp_CBE
81.66
73%
-134
- C3 -
-
5CSW
10.8
-
BRAF_HUMAN
A:
[8-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
A
-
S
E
-
T
--
K
----------
F
---------------
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-------
T
V
-
K
I
G
D
F
-------------------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
S
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
-
V
G
R
G
S
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
E
L
-----------------------------------
86
Blastp_CBE
81.64
77%
-138
- C3 -
-
1UWH
9.1
-
B:
[3-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
A
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
----------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
---------------------------------
114
Blastp_CBE
81.61
73%
-132
- C3 -
-
4WO5
2.6
-
B:
[27-298]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
A
-
S
E
-
T
--
K
----------
F
---------------
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
-------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
S
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
-
V
G
R
G
S
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
E
L
-----------------------------------
53
Blastp_CBE
81.51
74%
-127
- C3 -
-
4G9R
10.9
-
B:
[29-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
E
--
K
---------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
-----------------------------------
105
Blastp_CBE
81.45
73%
-145
- C3 -
-
6CAD
10.4
-
B:
[10-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
--
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
A
-
S
--
T
--
K
----------
F
---------------
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-------
T
V
-
K
I
G
D
F
------------------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
--------
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
-
V
G
R
G
S
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
E
L
-----------------------------------
110
Blastp_CBE
81.44
73%
-132
- C3 -
-
4JVG
8.3
-
BRAF_HUMAN
A:
[9-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
A
-
S
E
-
T
--
K
----------
F
---------------
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
--
K
S
---------------
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
S
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
-
V
G
R
G
S
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
E
L
-----------------------------------
132
Blastp_CBE
81.42
73%
-138
- C3 -
-
5JSM
9.4
-
BRAF_HUMAN
C:
[7-278]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
A
-
S
E
-
T
--
K
----------
F
---------------
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
E
-------------------
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
S
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
-
D
-
Q
I
I
E
M
-
V
G
R
G
S
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
E
L
-----------------------------------
113
Blastp_CBE
81.37
72%
-129
- C3 -
-
4FK3
8.9
-
BRAF_HUMAN
A:
[17-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
A
-
S
E
-
T
--
K
----------
F
---------------
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-------
T
V
-
K
I
G
D
F
G
-----------------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
---
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
-
V
G
R
G
S
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
--------------------------------------
37
Blastp_CBE
81.29
74%
-130
- C3 -
-
3PRI
7.7
-
B:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
----------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
---------------------------------
133
Blastp_CBE
81.24
73%
-138
- C3 -
-
5JSM
8.2
-
BRAF_HUMAN
B:
[7-278]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
A
-
S
E
-
T
--
K
----------
F
---------------
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
E
--
K
S
R
--------------
S
I
L
W
M
A
P
E
V
I
R
M
---
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
-
V
G
R
G
S
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
E
L
-----------------------------------
101
Blastp_CBE
81.10
73%
-137
- C3 -
-
3C4C
6.0
-
B:
[5-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
A
-
S
E
-
T
--
K
----------
F
---------------
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-------
T
V
-
K
I
G
D
F
------------------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
S
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
-
V
G
R
G
S
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
E
L
-----------------------------------
120
Blastp_CBE
81.08
72%
-140
- C3 -
-
4RZW
9.1
-
B:
[6-279]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
H
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
A
-
S
E
-
T
--
K
----------
F
---------------
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-------
T
V
-
K
I
G
D
F
-------------------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
---
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
-
V
G
R
G
S
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
E
L
-----------------------------------
138
Blastp_CBE
81.05
73%
-134
- C3 -
-
4CQE
11.2
-
BRAF_HUMAN
A:
[5-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
--
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
A
-
S
E
-
T
--
K
----------
F
---------------
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-------
T
V
-
K
I
G
D
F
G
------------------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
--
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
-
V
G
R
G
S
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
E
------------------------------------
89
Blastp_CBE
81.05
76%
-126
- C3 -
-
1UWJ
8.8
-
B:
[3-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
E
--
K
---------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
---------------------------------
140
Blastp_CBE
80.88
72%
-135
- C3 -
-
5HID
10.8
-
BRAF_HUMAN
A:
[14-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
-----
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
A
-
S
E
-
T
--
K
----------
F
---------------
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-------
T
V
-
K
I
G
D
F
G
L
A
------------------------
E
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
S
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
-
V
G
R
G
S
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
E
L
-----------------------------------
90
Blastp_CBE
80.85
76%
-126
- C3 -
-
1UWJ
9.4
-
BRAF_HUMAN
A:
[3-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
E
--
K
--------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
---------------------------------
13
PsiBlast_PDB
80.84
74%
-130
- C3 -
-
3PRI
7.6
-
BRAF_HUMAN
A:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
V
----------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
P
K
---------------------------------
111
Blastp_CBE
80.74
72%
-137
- C3 -
-
4R5Y
10.8
-
B:
[18-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
A
-
S
E
-
T
--
K
----------
F
---------------
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
--------
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
-
V
G
R
G
S
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
E
------------------------------------
137
Blastp_CBE
80.71
73%
-139
- C3 -
-
4CQE
11.1
-
B:
[5-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
---
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
A
-
S
E
-
T
--
K
----------
F
---------------
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-------
T
V
-
K
I
G
D
F
G
------------------------------
G
S
I
L
W
M
A
P
E
V
I
R
----
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
-
V
G
R
G
S
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
E
------------------------------------
103
Blastp_CBE
80.70
73%
-133
- C3 -
-
6NSQ
10.2
-
B:
[8-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
A
-
S
E
-
T
--
K
----------
F
---------------
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-------
T
V
-
K
I
G
D
F
G
------------------------------
G
S
I
L
W
M
A
P
E
V
I
R
---------
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
-
V
G
R
G
S
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
E
L
-----------------------------------
131
Blastp_CBE
80.67
73%
-135
- C3 -
-
5JSM
8.5
-
D:
[7-278]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
--
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
A
-
S
E
-
T
--
K
----------
F
---------------
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
E
--
K
S
-------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
---
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
---
D
-
Q
I
I
E
M
-
V
G
R
G
S
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
E
L
-----------------------------------
106
Blastp_CBE
80.58
73%
-139
- C3 -
-
6CAD
10.3
-
BRAF_HUMAN
A:
[10-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
-
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
--
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
A
-
S
E
-
T
--
K
----------
F
---------------
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-------
T
V
-
K
I
G
D
F
G
-----------------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
--------
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
-
N
R
D
-
Q
I
I
E
M
-
V
G
R
G
S
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
E
L
-----------------------------------
108
Blastp_CBE
80.55
73%
-130
- C3 -
-
4JVG
8.4
-
BRAF_HUMAN
C:
[9-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
A
-
S
E
-
T
--
K
----------
F
---------------
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-------
T
V
-
K
I
G
D
F
G
L
A
-----------------------------
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
S
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
-
V
G
R
G
S
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
E
L
-----------------------------------
54
Blastp_CBE
80.37
74%
-129
- C3 -
-
4G9R
10.8
-
BRAF_HUMAN
A:
[29-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
E
--
K
--------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
L
-----------------------------------
129
Blastp_CBE
80.36
73%
-136
- C3 -
-
5JT2
9.2
-
BRAF_HUMAN
B:
[7-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
----
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
A
-
S
E
-
T
--
K
----------
F
---------------
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
--------------------
S
I
L
W
M
A
P
E
V
I
R
M
--
S
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
-
V
G
R
G
S
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
-------------------------------------
118
Blastp_CBE
80.25
72%
-133
- C3 -
-
4XV2
10.9
-
BRAF_HUMAN
A:
[18-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
--
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
A
-
S
E
-
T
--
K
----------
F
---------------
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-------
T
V
-
K
I
G
D
F
G
------------------------------
G
S
I
L
W
M
A
P
E
V
I
R
---------
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
-
V
G
R
G
S
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
E
------------------------------------
136
Blastp_CBE
80.05
73%
-129
- C3 -
-
5JRQ
9.3
-
BRAF_HUMAN
A:
[7-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
A
-
S
E
-
T
--
K
----------
F
---------------
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
E
--
K
S
R
--------------
S
I
L
W
M
A
P
E
V
I
R
M
---
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
-
V
G
R
G
S
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
-------------------------------------
119
Blastp_CBE
80.03
72%
-142
- C3 -
-
4XV1
9.2
-
BRAF_HUMAN
A:
[18-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
---
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
-
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
A
-
S
-----
K
----------
F
---------------
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-------
T
V
-
K
I
G
D
F
G
-----------------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
----
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
-
V
G
R
G
S
--
L
--
S
P
D
L
S
-
K
V
----
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
----------------------------------------
116
Blastp_CBE
79.83
72%
-140
- C3 -
-
4XV3
8.5
-
BRAF_HUMAN
A:
[17-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
---
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
--
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
A
-
S
E
-
T
--
K
----------
F
---------------
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-------
T
V
-
K
I
G
D
F
G
-----------------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
----
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
-
V
G
R
G
S
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
---------------------------------------
141
Blastp_CBE
79.78
72%
-139
- C3 -
-
5HI2
9.5
-
A:
[14-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
-----
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
A
-
S
E
-
T
--
K
----------
F
---------------
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-------
T
V
-
K
I
G
D
F
G
L
------------------------------
S
I
L
W
M
A
P
E
V
I
R
M
---
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
-
V
G
R
G
S
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
E
L
-----------------------------------
130
Blastp_CBE
79.75
73%
-138
- C3 -
-
5JT2
8.6
-
BRAF_HUMAN
A:
[7-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
A
-
S
E
-
T
--
K
----------
F
---------------
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
E
--
K
S
R
W
-------------
S
I
L
W
M
A
P
E
V
I
----------
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
--
D
-
Q
I
I
E
M
-
V
G
R
G
S
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
-------------------------------------
112
Blastp_CBE
79.65
72%
-134
- C3 -
-
4R5Y
10.6
-
BRAF_HUMAN
A:
[18-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
A
-
S
E
-
T
--
K
----------
F
---------------
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-------
T
V
-
K
I
G
D
F
-------------------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
S
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
-
V
G
R
G
S
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
E
------------------------------------
124
Blastp_CBE
79.42
72%
-143
- C3 -
-
3OG7
9.6
-
BRAF_HUMAN
A:
[18-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
A
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
A
-
S
----------------
F
---------------
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-------
T
V
-
K
I
G
D
F
G
------------------------------
G
S
I
L
W
M
A
P
E
V
I
R
----
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
-
V
G
R
G
S
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
-------------------------------------
128
Blastp_CBE
78.93
73%
-140
- C3 -
-
5JT2
9.1
-
BRAF_HUMAN
C:
[7-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
--
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
A
-
S
E
-
T
--
K
----------
F
---------------
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
E
--
K
S
R
--------------
S
I
L
W
M
A
P
E
V
I
R
---------
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
-
I
N
N
----
I
I
E
M
-
V
G
R
G
------
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
-------------------------------------
102
Blastp_CBE
78.89
73%
-123
- C3 -
-
3C4C
8.1
-
BRAF_HUMAN
A:
[5-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
A
-
S
E
-
T
--
K
----------
F
---------------
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-------
T
V
-
K
I
G
D
F
G
-----------------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
S
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
E
M
-
V
G
R
G
S
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
E
L
-----------------------------------
135
Blastp_CBE
78.54
73%
-132
- C3 -
-
5JRQ
9.3
-
B:
[7-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
--
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
A
-
S
E
-
T
--
K
----------
F
---------------
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
E
--------------------
I
L
W
M
A
P
E
V
I
R
M
---
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
--------
I
I
E
M
-
V
G
R
G
S
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
R
E
------------------------------------
47
Blastp_CBE
77.48
74%
-145
- C3 -
-
5FD2
7.5
-
B:
[23-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
----------
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
------------
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
I
-
I
E
-
T
--
K
----------
F
---------------
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-------
T
V
-
K
I
G
D
F
G
-----------------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
-
Q
I
I
F
M
-
V
G
R
G
Y
--
L
--
S
P
D
L
S
-
K
V
R
S
--
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
-
L
L
A
R
S
------------------------------------
127
Blastp_CBE
74.48
73%
-129
- C3 -
-
5JT2
8.6
-
D:
[7-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
------
Y
K
G
K
W
--
H
------
G
--------
D
------
V
A
V
K
M
L
N
V
--
P
T
P
Q
-
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
--
K
--
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-------
H
A
-
S
E
-
T
--
K
----------
F
---------------
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
---
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-------
T
V
-
K
I
G
D
F
G
L
A
--------
T
E
-------------------
S
I
L
W
M
A
P
E
V
I
R
----
N
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
-----------------------
S
P
D
L
S
-
K
V
R
---
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
-
E
L
A
--------------------------------------
142
Blastp_CBE
58.34
36%
-63
- C3 -
-
2Y4I
4.9
-
B:
[28-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
D
I
P
F
E
Q
L
E
I
G
E
L
I
G
K
G
R
F
G
Q
V
------
Y
H
G
R
W
--
H
------
G
--------
E
------
V
A
I
R
L
I
D
I
E
R
D
N
E
D
-
Q
L
K
A
F
K
R
E
V
M
A
Y
R
Q
T
-
R
H
E
N
V
V
L
F
M
G
-
A
C
M
S
--
P
--
P
H
---
L
A
I
I
T
S
L
C
K
G
R
T
L
Y
S
V
V
-------
R
D
-
A
K
-
I
--
V
----------
L
---------------
D
V
N
K
T
R
Q
I
A
Q
E
I
V
K
G
M
G
Y
L
H
--
A
---
K
G
---
I
L
H
K
D
L
K
S
K
N
V
F
Y
D
--
K
-------
V
V
--
I
T
D
F
G
L
F
--------
S
-----------ED
K
L
R
I
Q
N
G
W
L
C
H
L
A
P
E
I
I
R
Q
L
S
P
D
EDKL
P
F
S
K
H
S
D
V
F
A
L
G
T
I
W
Y
E
L
H
A
-
R
E
W
P
F
K
-
T
Q
P
A
E
-
A
I
I
W
Q
-
M
G
T
G
---
M
--
K
P
N
L
S
-
Q
I
G
M
--
G
--
K
E
I
S
D
I
L
L
F
C
W
A
F
E
Q
E
E
R
P
T
F
T
K
L
M
D
M
L
E
-----
K
L
-----------------------------------
143
Blastp_CBE
56.39
36%
-50
- C3 -
-
5KKR
7.7
-
B:
[28-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
D
I
P
F
E
Q
L
E
I
G
E
L
I
G
---
F
G
Q
V
------
Y
H
G
R
W
--
H
------
G
--------
E
------
V
A
I
R
L
I
D
I
E
R
D
N
E
D
-
Q
L
K
A
F
K
R
E
V
M
A
Y
R
Q
T
-
R
H
E
N
V
V
L
F
M
G
-
A
C
M
S
--
P
--
P
H
---
L
A
I
I
T
S
L
C
K
G
R
T
L
Y
S
V
V
-------
R
D
-
A
K
-
I
--
V
----------
L
---------------
D
V
N
K
T
R
Q
I
A
Q
E
I
V
K
G
M
G
Y
L
H
--
A
---
K
G
---
I
L
H
K
D
L
K
S
K
N
V
F
Y
D
N
G
K
-------
V
V
--
I
T
D
F
G
L
F
--------
S
I
--
S
G
V
L
Q
---D-
K
L
R
I
Q
N
G
W
L
C
H
L
A
P
E
I
I
R
Q
L
S
P
D
DKL-
P
F
S
K
H
S
D
V
F
A
L
G
T
I
W
Y
E
L
H
A
-
R
E
W
P
F
K
-
T
Q
P
A
E
-
A
I
I
W
Q
-
M
G
T
G
---
M
--
K
P
N
L
S
-
Q
I
G
M
--
G
--
K
E
I
S
D
I
L
L
F
C
W
A
F
E
Q
E
E
R
P
T
F
T
K
L
M
D
M
L
E
-----
K
L
P
----------------------------------
146
Blastp_CBE
55.98
35%
-55
- C3 -
-
3P86
5.7
-
CTR1_ARATH
A:
[33-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
P
W
C
D
L
N
I
K
E
K
I
G
A
G
S
F
G
T
V
------
H
R
A
E
W
--
H
------
G
S-------
D
------
V
A
V
K
I
L
M
E
Q
D
F
H
A
E
-
R
V
N
E
F
L
R
E
V
A
I
M
K
R
L
-
R
H
P
N
I
V
L
F
M
G
-
A
-
V
T
--
Q
P-
P
N
---
L
S
I
V
T
E
Y
L
S
R
G
S
L
Y
R
L
L
-------
H
K
-
S
G
-
A
--
R
EQ--------
L
---------------
D
E
R
R
R
L
S
M
A
Y
D
V
A
K
G
M
N
Y
L
H
--
N
---
R
N
PP-
I
V
H
R
N
L
K
S
P
N
L
L
V
D
K
K
Y
-------
T
V
-
K
V
C
D
F
-------------------------------
G
T
P
E
W
M
A
P
E
V
L
R
D
E
-------
P
S
N
E
K
S
D
V
Y
S
F
G
V
I
L
W
E
L
A
T
-
L
Q
Q
P
W
G
N
L
N
P
A
--
Q
V
V
A
A
-
V
G
-----
F
--
K
C
K
R
L
-
E
I
P
R
--
N
L
N
P
Q
V
A
A
I
I
E
G
C
W
T
N
E
P
W
K
R
P
S
F
A
T
I
M
D
L
L
R
P
L
I
K
--------------------------------------
498
Blastp_CBE
55.64
32%
-16
- C3 -
-
1T46
8.4
-
?
A:
[18-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
------
V
E
A
T
A
--
Y
------
G
LIKSDAAM
T
------
V
A
V
K
M
L
K
P
S
A
H
L
T
E
-
R
-
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
-
A
-
C
T
--
I
--
G
G
P--
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
-------
R
R
-
K
R
-
D
--
S
----------
F
LAL------------
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
--
S
---
K
N
---
C
I
H
R
D
L
A
A
R
N
I
L
L
T
H
G
R
-------
I
T
-
K
I
C
D
F
G
L
A
--------
R
D
--
I
K
N
D
S
N
Y
V
--
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
---
N
C
----
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
D
S
-
K
F
Y
K
M
-
I
K
E
G
F
RM
L
--
S
P
E
---------
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
------------------------------------------
492
Blastp_CBE
55.54
33%
-24
- C3 -
-
6HH1
9.9
-
?
A:
[18-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
------
V
E
A
T
A
--
Y
------
G
LIKSDAAM
T
------
V
A
V
K
M
L
K
P
S
A
H
L
T
E
-
R
-
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
-
A
-
C
T
--
I
--
G
G
P--
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
-------
R
R
-
K
R
-
D
--
S
----------
F
ICSKTSPAIELAL--
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
--
S
---
K
N
---
C
I
H
R
D
L
A
A
R
N
I
L
L
T
H
G
R
-------
I
T
-
K
I
C
D
F
G
L
A
--------
R
D
--
I
K
N
D
S
N
Y
V
--
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
---
N
C
----
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
D
S
-
K
F
Y
K
M
-
I
K
E
G
F
RM
L
--
S
P
E
---------
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
------------------------------------------
451
Blastp_CBE
55.09
31%
-39
- C3 -
-
4O91
11.0
-
M3K7_HUMAN
A:
[9-278]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
E
V
E
E
V
V
G
R
G
A
F
G
V
V
------
C
K
A
K
W
--
R
------
A
K-------
D
------
V
A
I
K
Q
I
E
----
S
E
S
-
E
R
K
A
F
I
V
E
L
R
Q
L
S
R
V
-
N
H
P
N
I
V
K
L
Y
G
-
A
-
C
L
--
N
--
P
----
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
N
V
L
-------
H
G
-
A
E
-
P
LP
Y
----------
Y
---------------
T
A
A
H
A
M
S
W
C
L
Q
C
S
Q
G
V
A
Y
L
H
--
S
MQP
K
A
---
L
I
H
R
D
L
K
P
P
N
L
L
L
V
A
G
G
-------
T
V
L
K
I
C
D
F
G
------------------------------
G
S
A
A
W
M
A
P
E
V
F
E
G
S
N
-------
Y
S
E
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
-
R
R
K
P
F
D
E
I
G
G
P
A
F
R
I
M
W
A
-
V
H
N
G
T
--
R
--
P
P
-----
L
I
K
--
N
L
P
K
P
I
E
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
V
K
I
M
T
-
H
L
M
R
Y
F
P
G
A
D
E
P
L
Q
Y
P
C
Q
H
----------------------
468
Blastp_CBE
54.81
32%
-8
- C3 -
-
4HVS
8.4
-
A:
[41-326]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
------
V
E
A
T
A
--
Q
------
G
LIKSDAAM
T
------
V
A
V
K
M
L
K
P
S
A
H
S
T
E
-
R
-
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
E
N
I
V
N
L
L
G
-
A
-
C
T
--
H
--
G
G
P--
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
RRKRDSF
H
S
-
S
D
-
T
--
S
PASMEDDENA
L
---------------
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
--
S
---
K
N
---
C
I
H
R
D
L
A
A
R
N
I
L
L
T
H
G
R
-------
I
T
-
K
I
C
D
F
G
L
A
--------
R
D
--
I
K
N
D
S
N
Y
V
--
D
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
---
N
S
----
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
D
S
-
K
F
Y
K
M
-
I
K
E
G
F
-----------
R
M
S
S
PE
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
D
K
R
P
T
F
K
Q
I
V
Q
D
I
E
------------------------------------------
458
Blastp_CBE
54.49
31%
-33
- C3 -
-
5V5N
6.4
-
M3K7_HUMAN
A:
[9-278]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
E
V
E
E
V
V
G
R
G
A
F
G
V
V
------
C
K
A
K
W
--
R
------
A
K-------
D
------
V
A
I
K
Q
I
E
----
S
E
S
-
E
R
K
A
F
I
V
E
L
R
Q
L
S
R
V
-
N
H
P
N
I
V
K
L
Y
G
-
A
-
C
L
--
N
--
P
----
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
N
V
L
-------
H
G
-
A
E
-
P
LP
Y
----------
Y
---------------
T
A
A
H
A
M
S
W
C
L
Q
C
S
Q
G
V
A
Y
L
H
--
S
MQP
K
A
---
L
I
H
R
D
L
K
P
P
N
L
L
L
V
A
G
G
-------
T
V
L
K
I
C
D
F
G
T
-----------------------------
G
S
A
A
W
M
A
P
E
V
F
E
G
S
N
-------
Y
S
E
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
-
R
R
K
P
F
D
E
I
G
G
P
A
F
R
I
M
W
A
-
V
H
N
G
T
--
R
--
P
P
-----
L
I
K
--
N
L
P
K
P
I
E
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
V
K
I
M
T
-
H
L
M
R
Y
F
P
G
A
D
E
P
L
Q
Y
P
C
Q
H
----------------------
500
Blastp_CBE
53.58
32%
-9
- C3 -
-
4U0I
10.7
-
A:
[20-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
------
V
E
A
T
A
--
Y
------
G
LIAAM---
T
------
V
A
V
K
M
L
K
P
S
A
H
L
T
E
-
R
-
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
-
A
-
C
T
--
I
--
G
G
P--
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
-------
R
R
-
K
R
-
D
--
S
----------
F
ICSLAL---------
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
--
S
---
K
N
---
C
I
H
R
D
L
A
A
R
N
I
L
L
T
H
G
R
-------
I
T
-
K
I
C
D
F
G
L
A
--------
R
D
--
I
K
N
D
S
N
Y
V
--
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
---
N
C
----
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
D
S
-
K
F
Y
K
M
-
I
K
E
G
F
RM
L
--
S
P
E
---------
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
------------------------------------------
484
Blastp_CBE
53.27
32%
-17
- C3 -
-
6GQJ
8.5
-
?
A:
[36-319]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
------
V
E
A
T
A
--
Q
------
G
LIKSDAAM
T
------
V
A
V
K
M
L
K
P
S
A
H
S
T
E
-
R
-
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
E
N
I
V
N
L
L
G
-
A
-
C
T
--
H
--
G
G
P--
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
-------
R
R
-
K
R
-
D
--
E
----------
F
VPYKKDFL-------
T
L
E
H
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
--
S
---
K
N
---
C
I
H
R
D
L
A
A
R
N
I
L
L
T
H
G
N
-------
I
T
-
K
I
C
D
F
G
L
A
--------
R
D
--
I
K
N
D
S
N
Y
V
--
D
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
---
N
S
----
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
D
S
-
K
F
Y
K
M
-
I
K
E
G
F
--
R
MS
S
P
E
Y
A
---------
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
D
K
R
P
T
F
K
Q
I
V
Q
D
I
E
------------------------------------------
488
Blastp_CBE
53.25
32%
-9
- C3 -
-
6GQL
9.7
-
KIT_HUMAN
A:
[36-319]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
------
V
E
A
T
A
--
Q
------
G
LIKSDAAM
T
------
V
A
V
K
M
L
K
P
S
A
H
S
T
E
-
R
-
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
E
N
I
V
N
L
L
G
-
A
-
C
T
--
H
--
G
G
P--
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
-------
R
R
-
K
R
-
D
--
E
----------
F
VPYLYKDFL------
T
L
E
H
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
--
S
---
K
N
---
C
I
H
R
D
L
A
A
R
N
I
L
L
T
H
G
N
-------
I
T
-
K
I
C
D
F
G
L
A
--------
R
D
--
I
K
N
D
S
N
Y
V
--
D
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
---
N
S
----
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
D
S
-
K
F
Y
K
M
-
I
K
E
G
F
--
R
MS
S
P
E
Y
A
---------
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
D
K
R
P
T
F
K
Q
I
V
Q
D
I
E
------------------------------------------
502
Blastp_CBE
53.22
32%
-35
- C3 -
-
1PKG
5.8
-
B:
[34-319]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
------
V
E
A
T
A
--
Y
------
G
LIKSDAAM
T
------
V
A
V
K
M
L
K
P
S
A
H
L
T
E
-
R
-
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
-
A
-
C
T
--
I
--
G
G
P--
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
-------
R
R
-
K
R
-
D
--
S
----------
F
ICL------------
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
--
S
---
K
N
---
C
I
H
R
D
L
A
A
R
N
I
L
L
T
H
G
R
-------
I
T
-
K
I
C
D
F
G
L
A
--------
R
D
-----------------
R
L
P
V
K
W
M
A
P
E
S
I
F
---
N
C
----
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
D
S
-
K
F
Y
K
M
-
I
K
E
G
F
RM
L
--
S
P
E
---------
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
------------------------------------------
503
Blastp_CBE
53.14
32%
-23
- C3 -
-
1PKG
6.0
-
KIT_HUMAN
A:
[34-319]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
------
V
E
A
T
A
--
Y
------
G
LIKSDAAM
T
------
V
A
V
K
M
L
K
P
S
A
H
L
T
E
-
R
-
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
-
A
-
C
T
--
I
--
G
G
P--
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
-------
R
R
-
K
R
-
D
--
S
----------
F
ICSKAL---------
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
--
S
---
K
N
---
C
I
H
R
D
L
A
A
R
N
I
L
L
T
H
G
R
-------
I
T
-
K
I
C
D
F
G
L
A
--------
R
D
--
I
K
N
D
S
N
Y
V
--
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
---
N
C
----
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
D
S
-
K
F
Y
K
M
-
I
K
E
G
F
RM
L
--
S
P
E
---------
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
------------------------------------------
367
Blastp_CBE
52.97
33%
-23
- C3 -
-
5L6O
2.8
-
A:
[20-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
V
K
I
E
E
V
I
G
A
---
G
E
V
------
C
R
G
R
L
--
K
------
Q
--------
P
GRREVF
V
A
I
K
T
L
K
V
G
Y
-
T
E
R
-
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
-
D
H
P
N
I
I
R
L
E
G
-
V
-
V
T
KS
R
--
P
----
V
M
I
L
T
E
F
M
E
N
C
A
L
D
S
F
L
-------
R
L
-
N
D
-
G
--
Q
----------
F
---------------
T
V
I
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
S
--
E
---
M
N
---
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
-------
V
C
-
K
V
S
D
F
G
--LEDDPSDP
T
Y
--
T
S
S
L
G
G
K
I
--
P
I
R
-------
W
T
A
P
E
A
I
A
Y
R
-------
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
S
N
Q
D
--
V
I
N
A
-
V
E
Q
D
Y
--
R
--
L
P
P
-----
P
M
--
D
C
P
T
A
L
H
Q
L
M
L
D
C
W
V
R
D
R
N
L
R
P
K
F
S
Q
I
V
N
T
L
D
-
K
L
I
R
N
P
A
S
L
K
V
I
-----------------------------
490
Blastp_CBE
52.30
32%
-10
- C3 -
-
6GQK
7.4
-
?
A:
[36-319]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
------
V
E
A
T
A
--
Q
------
G
LIKSDAAM
T
------
V
A
V
K
M
L
K
P
S
A
H
S
T
E
-
R
-
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
E
N
I
V
N
L
L
G
-
A
-
C
T
--
H
--
G
G
P--
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
-------
R
R
-
K
R
-
D
--
E
----------
F
VPYKVAPEDLYKDFL
T
L
E
H
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
--
S
---
K
N
---
C
I
H
R
D
L
A
A
R
N
I
L
L
T
H
G
N
-------
I
T
-
K
I
C
D
F
G
L
A
--------
R
D
--
I
K
N
D
S
N
Y
V
--
D
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
---
N
S
----
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
D
S
-
K
F
Y
K
M
-
I
K
E
G
F
--
R
MS
S
P
E
Y
A
---------
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
D
K
R
P
T
F
K
Q
I
V
Q
D
I
E
------------------------------------------
427
Blastp_CBE
52.22
32%
-27
- C3 -
-
4UYA
4.6
-
M3K21_HUMAN
A:
[19-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
V
H
--
V
A
F
E
R
L
E
L
K
E
L
I
G
A
---
G
Q
V
------
Y
R
A
T
W
--
Q
------
G
Q-------
E
------
V
A
V
K
--------
A
A
-
A
A
E
S
V
R
R
E
A
R
L
F
A
M
L
-
R
H
P
N
I
I
E
L
R
G
-
V
C
L
Q
--
Q
--
P
H
---
L
C
L
V
L
E
F
A
R
G
G
A
L
N
R
A
L
----------
A
G
-
R
--
R
----------
I
---------------
P
P
H
V
L
V
N
W
A
V
Q
I
A
R
G
M
L
Y
L
H
--
E
---
E
A
FVP
I
L
H
R
D
L
K
S
S
N
I
L
L
L
E
K
I
EHDICNK
T
L
-
K
I
T
D
F
-------------------------------
G
A
Y
A
W
M
A
P
E
V
I
K
---
S
S
----
L
F
S
K
G
S
D
I
W
S
Y
G
V
L
L
W
E
L
L
T
-
G
E
V
P
Y
R
G
I
D
G
------
L
A
-
V
A
Y
G
V
--
A
--
V
N
K
L
T
L
P
I
P
S
--
T
C
P
E
P
F
A
K
L
M
K
E
C
W
Q
Q
D
P
H
I
R
P
S
F
A
L
I
L
E
Q
L
T
-
A
--------
M
T
E
M
P
Q
E
S
F
H
S
---
M
Q
D
D
--------------
454
Blastp_CBE
51.50
32%
-45
- C3 -
-
5D7V
2.3
-
PTK6_HUMAN
D:
[2-254]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
P
R
E
E
F
T
L
C
R
K
L
G
S
G
Y
F
G
E
V
------
F
E
G
L
W
--
K
------
D
--------
R
------
V
Q
V
A
I
K
V
I
S
R
D
N
L
L
-
H
Q
Q
M
L
Q
S
E
I
Q
A
M
K
K
L
-
R
H
K
H
I
L
A
L
Y
A
-
V
-
V
S
VG
D
--
P
V
---
Y
-
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
-------
R
D
-
S
D
-
E
--
K
V---------
L
---------------
P
V
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
--
S
---
Q
N
---
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
-------
L
C
-
K
V
G
D
F
G
L
A
R-------
L
I
--
K
E
D
V
Y
L
S
H
--
D
H
N
I
P
Y
K
---
W
T
A
P
E
A
L
---
S
R
G
----
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
--
G
M
S
N
-
H
E
A
F
L
R
V
D
A
G
Y
--
R
--
M
P
-----
C
P
L
--
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
-----------------------------------------------
145
Blastp_CBE
51.45
36%
-29
- C3 -
-
3PPZ
7.5
-
CTR1_ARATH
A:
[33-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
P
W
C
D
L
N
I
K
E
K
I
G
A
G
S
F
G
T
V
------
H
R
A
E
W
--
H
------
G
S-------
D
------
V
A
V
K
I
L
M
E
----
A
E
-
R
V
N
E
F
L
R
E
V
A
I
M
K
R
L
-
R
H
P
N
I
V
L
F
M
G
-
A
-
V
T
--
Q
P-
P
N
---
L
S
I
V
T
E
Y
L
S
R
G
S
L
Y
R
L
L
-------
H
K
-
S
G
-
A
--
R
EQ--------
L
---------------
D
E
R
R
R
L
S
M
A
Y
D
V
A
K
G
M
N
Y
L
H
--
N
---
R
N
PP-
I
V
H
R
D
L
K
S
P
N
L
L
V
D
K
K
Y
-------
T
V
-
K
V
C
D
F
G
L
S
--------
R
L
--
K
-----
A
S
--
F
L
S
K
A
A
G
T
P
E
W
M
A
P
E
V
L
R
D
E
-------
P
S
N
E
K
S
D
V
Y
S
F
G
V
I
L
W
E
L
A
T
-
L
Q
Q
P
W
G
N
L
N
P
A
--
Q
V
V
A
A
-
V
G
-----
F
--
K
C
K
R
L
-
E
I
P
R
--
N
L
N
P
Q
V
A
A
I
I
E
G
C
W
T
N
E
P
W
K
R
P
S
F
A
T
I
M
D
L
L
R
P
L
I
K
S
A
V
-----------------------------------
283
Blastp_CBE
51.28
32%
-45
- C3 -
-
3F3U
5.5
-
SRC_CHICK
B:
[13-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
T
W
--
N
------
G
--------
T
TR----
V
A
I
K
T
L
K
---
P
G
---
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
--
E
--
E
P
---
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
-------
K
G
-
E
M
-
G
--
K
----------
Y
L--------------
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
--
R
---
M
N
---
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
-------
V
C
-
K
V
A
D
F
G
L
--------------------------
F
P
---
I
K
W
T
A
P
E
A
A
L
Y
---
G
----
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
--
V
L
D
Q
-
V
E
R
G
Y
--
R
--
M
P
-----
C
P
P
--
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
------------------------------------------
563
HHSearch
51.26
30%
-48
- C3 -
-
4YFI
6.4
-
TNI3K_HUMAN
C:
[57-326]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
Q
L
S
E
I
E
F
H
E
I
I
G
S
G
S
F
G
K
V
------
Y
K
G
R
C
--
R
------
N
K-------
I
------
V
A
I
K
R
Y
R
------
S
-
D
V
D
M
F
C
R
E
V
S
I
L
C
Q
L
-
N
H
P
C
V
I
Q
F
V
G
-
A
-
C
L
--
N
DP
S
Q
---
F
A
I
V
T
Q
Y
I
S
G
G
S
L
F
S
L
L
-------
H
E
-
Q
K
-
R
--
I
----------
L
---------------
D
L
Q
S
K
L
I
I
A
V
D
V
A
K
G
M
E
Y
L
H
--
N
LT-
Q
P
---
I
I
H
R
D
L
N
S
H
N
I
L
L
Y
E
D
G
-------
H
A
-
V
V
A
D
F
G
E
S
--------
R
F
--
L
Q
S
-------------
G
N
L
R
W
M
A
P
E
V
F
T
Q
C
--
T
----
R
Y
T
I
K
A
D
V
F
S
Y
A
L
C
L
W
E
I
L
T
-
G
E
I
P
F
A
H
L
K
P
A
A
-
A
D
M
D
M
-
A
Y
H
H
I
-----
R
P
----
P
I
G
Y
--
S
I
P
K
P
I
S
S
L
L
I
R
G
W
N
A
C
P
E
G
R
P
E
F
S
E
V
V
M
K
L
E
-
E
C
L
C
N
I
-----------------------------------
389
Blastp_CBE
51.26
31%
-28
- C3 -
-
4LUD
3.1
-
HCK_HUMAN
B:
[183-440]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
------
W
M
A
T
Y
NK
H
------
T
--------
K
------
V
A
V
K
T
M
K
---
P
G
---
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
-
V
-
V
T
--
K
--
E
P
---
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
-------
K
S
-
D
E
G
S
--
K
----------
Q
---------------
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
--
Q
---
R
N
---
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
-------
V
C
-
K
I
A
D
F
G
L
A
--------
R
V
I---------------
P
---
I
K
W
T
A
P
E
A
I
N
F
---
G
----
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
N
P
-
E
V
I
R
A
-
L
E
R
G
Y
--
R
--
M
P
R
-----
P
E
--
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
------------------------------------------
456
Blastp_CBE
51.07
32%
-44
- C3 -
-
5D7V
2.4
-
PTK6_HUMAN
B:
[2-254]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
P
R
E
E
F
T
L
C
R
K
L
G
S
G
Y
F
G
E
V
------
F
E
G
L
W
--
K
------
D
--------
R
------
V
Q
V
A
I
K
V
I
S
R
D
N
L
L
-
H
Q
Q
M
L
Q
S
E
I
Q
A
M
K
K
L
-
R
H
K
H
I
L
A
L
Y
A
-
V
-
V
S
VG
D
--
P
V
---
Y
-
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
-------
R
D
-
S
D
-
E
--
K
V---------
L
---------------
P
V
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
--
S
---
Q
N
---
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
-------
L
C
-
K
V
G
D
F
G
L
A
R-------
L
I
--
K
E
D
V
Y
L
S
H
--
D
H
N
I
P
Y
K
---
W
T
A
P
E
A
L
---
S
R
G
----
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
--
G
M
S
N
-
H
E
A
F
L
R
V
D
A
G
Y
--
R
--
M
P
-----
C
P
L
--
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
-----------------------------------------------
455
Blastp_CBE
50.59
32%
-53
- C3 -
-
5D7V
1.7
-
PTK6_HUMAN
C:
[2-254]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
P
R
E
E
F
T
L
C
R
K
L
G
S
G
Y
F
G
E
V
------
F
E
G
L
W
--
K
------
D
--------
R
------
V
Q
V
A
I
K
V
I
S
R
D
N
L
L
-
H
Q
Q
M
L
Q
S
E
I
Q
A
M
K
K
L
-
R
H
K
H
I
L
A
L
Y
A
-
V
-
V
S
VG
D
--
P
V
---
Y
-
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
-------
R
D
-
S
D
-
E
--
K
V---------
L
---------------
P
V
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
--
S
---
Q
N
---
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
-------
L
C
-
K
V
G
D
F
G
L
A
R-------
L
I
--
K
E
D
V
Y
L
S
H
--
D
H
N
I
P
Y
K
---
W
T
A
P
E
A
L
---
S
R
G
----
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
--
G
M
S
N
-
H
E
A
F
L
R
V
D
A
G
Y
--
R
--
M
P
-----
C
P
L
--
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
-----------------------------------------------
457
Blastp_CBE
50.58
32%
-43
- C3 -
-
5D7V
2.5
-
PTK6_HUMAN
A:
[2-254]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
P
R
E
E
F
T
L
C
R
K
L
G
S
G
Y
F
G
E
V
------
F
E
G
L
W
--
K
------
D
--------
R
------
V
Q
V
A
I
K
V
I
S
R
D
N
L
L
-
H
Q
Q
M
L
Q
S
E
I
Q
A
M
K
K
L
-
R
H
K
H
I
L
A
L
Y
A
-
V
-
V
S
VG
D
--
P
V
---
Y
-
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
-------
R
D
-
S
D
-
E
--
K
V---------
L
---------------
P
V
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
--
S
---
Q
N
---
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
-------
L
C
-
K
V
G
D
F
G
L
A
R-------
L
I
--
K
E
D
V
Y
L
S
H
--
D
H
N
I
P
Y
K
---
W
T
A
P
E
A
L
---
S
R
G
----
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
--
G
M
S
N
-
H
E
A
F
L
R
V
D
A
G
Y
--
R
--
M
P
-----
C
P
L
--
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
-----------------------------------------------
388
Blastp_CBE
50.51
31%
-24
- C3 -
-
4LUE
2.8
-
HCK_HUMAN
A:
[183-440]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
------
W
M
A
T
Y
NK
H
------
T
--------
K
------
V
A
V
K
T
M
K
---
P
G
S
-------
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
-
V
-
V
T
--
K
--
E
P
---
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
-------
K
S
-
D
E
G
S
--
K
----------
Q
---------------
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
--
Q
---
R
N
---
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
-------
V
C
-
K
I
A
D
F
G
L
A
--------
R
V
I---------------
P
---
I
K
W
T
A
P
E
A
I
N
F
---
G
----
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
N
P
-
E
V
I
R
A
-
L
E
R
G
Y
--
R
--
M
P
R
-----
P
E
--
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
------------------------------------------
463
Blastp_CBE
50.40
32%
-48
- C3 -
-
5H2U
2.0
-
PTK6_HUMAN
C:
[2-254]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
P
R
E
E
F
T
L
C
R
K
L
G
S
G
Y
F
G
E
V
------
F
E
G
L
W
--
K
------
D
--------
R
------
V
Q
V
A
I
K
V
I
S
R
D
N
L
L
-
H
Q
Q
M
L
Q
S
E
I
Q
A
M
K
K
L
-
R
H
K
H
I
L
A
L
Y
A
-
V
-
V
S
VG
D
--
P
V
---
Y
-
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
-------
R
--
S
D
-
E
--
K
V---------
L
---------------
P
V
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
--
S
---
Q
N
---
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
-------
L
C
-
K
V
G
D
F
G
L
A
R-------
L
I
--
K
E
D
V
Y
L
S
H
--
D
H
N
I
P
Y
K
---
W
T
A
P
E
A
L
---
S
R
G
----
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
--
G
M
S
N
-
H
E
A
F
L
R
V
D
A
G
Y
--
R
--
M
P
-----
C
P
L
--
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
-----------------------------------------------
464
Blastp_CBE
50.35
32%
-44
- C3 -
-
5H2U
2.1
-
PTK6_HUMAN
B:
[2-254]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
P
R
E
E
F
T
L
C
R
K
L
G
S
G
Y
F
G
E
V
------
F
E
G
L
W
--
K
------
D
--------
R
------
V
Q
V
A
I
K
V
I
S
R
D
N
L
L
-
H
Q
Q
M
L
Q
S
E
I
Q
A
M
K
K
L
-
R
H
K
H
I
L
A
L
Y
A
-
V
-
V
S
VG
D
--
P
V
---
Y
-
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
-------
R
--
S
D
-
E
--
K
V---------
L
---------------
P
V
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
--
S
---
Q
N
---
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
-------
L
C
-
K
V
G
D
F
G
L
A
R-------
L
I
--
K
E
D
V
Y
L
S
H
--
D
H
N
I
P
Y
K
---
W
T
A
P
E
A
L
---
S
R
G
----
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
--
G
M
S
N
-
H
E
A
F
L
R
V
D
A
G
Y
--
R
--
M
P
-----
C
P
L
--
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
-----------------------------------------------
465
Blastp_CBE
50.27
32%
-47
- C3 -
-
5H2U
1.8
-
PTK6_HUMAN
A:
[2-254]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
P
R
E
E
F
T
L
C
R
K
L
G
S
G
Y
F
G
E
V
------
F
E
G
L
W
--
K
------
D
--------
R
------
V
Q
V
A
I
K
V
I
S
R
D
N
L
L
-
H
Q
Q
M
L
Q
S
E
I
Q
A
M
K
K
L
-
R
H
K
H
I
L
A
L
Y
A
-
V
-
V
S
VG
D
--
P
V
---
Y
-
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
-------
R
--
S
D
-
E
--
K
V---------
L
---------------
P
V
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
--
S
---
Q
N
---
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
-------
L
C
-
K
V
G
D
F
G
L
A
R-------
L
I
--
K
E
D
V
Y
L
S
H
--
D
H
N
I
P
Y
K
---
W
T
A
P
E
A
L
---
S
R
G
----
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
--
G
M
S
N
-
H
E
A
F
L
R
V
D
A
G
Y
--
R
--
M
P
-----
C
P
L
--
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
-----------------------------------------------
445
Blastp_CBE
50.23
31%
-19
- C3 -
-
2HEN
5.4
-
EPHB2_MOUSE
A:
[3-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
I
S
C
V
K
I
E
Q
V
I
G
A
G
E
F
G
E
V
CSGHLK
L
P
G
K
R
--
E
------
I
--------
F
------
V
A
I
K
T
L
K
-
S
G
Y
T
E
K
-
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
-
D
H
P
N
V
I
H
L
E
G
-
V
-
V
T
--
K
--
S
T
P--
V
M
I
I
T
E
F
M
E
N
G
S
L
D
S
F
L
-------
R
Q
-
N
D
-
G
--
Q
----------
F
---------------
T
V
I
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
--
D
---
M
N
---
Y
V
H
R
A
L
A
A
R
N
I
L
V
N
S
N
L
-------
V
C
-
K
V
S
D
F
G
------------------------
P
I
R
-------
W
T
A
P
E
A
I
Q
Y
R
-------
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
T
N
Q
D
--
V
I
N
A
-
I
E
Q
D
Y
R-
L
--
P
P
P
M
--------
D
C
P
S
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
H
R
P
K
F
G
Q
I
V
N
T
L
D
-
K
M
I
R
N
------------------------------------
462
Blastp_CBE
49.87
32%
-46
- C3 -
-
5H2U
2.2
-
PTK6_HUMAN
D:
[2-254]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
P
R
E
E
F
T
L
C
R
K
L
G
S
G
Y
F
G
E
V
------
F
E
G
L
W
--
K
------
D
--------
R
------
V
Q
V
A
I
K
V
I
S
R
D
N
L
L
-
H
Q
Q
M
L
Q
S
E
I
Q
A
M
K
K
L
-
R
H
K
H
I
L
A
L
Y
A
-
V
-
V
S
VG
D
--
P
V
---
Y
-
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
-------
R
--
S
D
-
E
--
K
V---------
L
---------------
P
V
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
--
S
---
Q
N
---
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
-------
L
C
-
K
V
G
D
F
G
L
A
R-------
L
I
--
K
E
D
V
Y
L
S
H
--
D
H
N
I
P
Y
K
---
W
T
A
P
E
A
L
---
S
R
G
----
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
--
G
M
S
N
-
H
E
A
F
L
R
V
D
A
G
Y
--
R
--
M
P
-----
C
P
L
--
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
-----------------------------------------------
387
Blastp_CBE
49.76
31%
-30
- C3 -
-
4LUE
2.8
-
HCK_HUMAN
B:
[183-440]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
------
W
M
A
T
Y
NK
H
------
T
--------
K
------
V
A
V
K
T
M
K
---
P
---------
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
-
V
-
V
T
--
K
--
E
P
---
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
-------
K
S
-
D
E
G
S
--
K
----------
Q
---------------
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
--
Q
---
R
N
---
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
-------
V
C
-
K
I
A
D
F
G
L
A
--------
R
V
I---------------
P
---
I
K
W
T
A
P
E
A
I
N
----------
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
N
P
-
E
V
I
R
A
-
L
E
R
G
Y
--
R
--
M
P
R
-----
P
E
--
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
------------------------------------------
242
Blastp_CBE
48.71
31%
-49
- C3 -
-
1QPC
2.2
-
?
A:
[8-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
R
E
T
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
------
W
M
G
Y
Y
--
N
------
G
--------
H
------
T
K
V
A
V
K
S
L
K
Q
G
S
M
--
S
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
-
V
-
V
T
--
Q
--
E
P
---
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
-------
K
T
P
S
G
-
I
--
K
----------
L
---------------
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
--
E
---
R
N
---
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
-------
S
C
-
K
I
A
D
F
G
L
A
--------
R
L
--
I
E
D
N
E
T
A
R
----
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
---
G
----
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
-
T
N
P
-
E
V
I
Q
N
-
L
E
R
G
Y
RM
V
--
R
P
D
---------
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
------------------------------------------
149
Blastp_CBE
47.82
34%
-15
- C3 -
-
2DQ7
3.4
-
X:
[4-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
R
E
S
L
Q
L
I
K
R
L
G
N
G
Q
F
G
E
V
------
W
M
G
T
W
--
N
------
G
--------
N
TK----
V
A
I
K
T
L
K
---
P
G
T
M
-
S
P
E
S
F
L
E
E
A
Q
I
M
K
K
L
-
K
H
D
K
L
V
Q
L
Y
A
-
V
-
V
S
--
E
--
E
P
---
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
-------
K
D
-
G
E
-
G
--
R
A---------
L
---------------
K
L
P
N
L
V
D
M
A
A
Q
V
A
A
G
M
A
Y
I
E
--
R
---
M
N
---
Y
I
H
R
D
L
R
S
A
N
I
L
V
G
N
G
L
-------
I
C
-
K
I
A
D
F
G
L
A
R-------
L
I
--
E
D
N
E
T
A
R
Q
--
G
A
K
F
P
---
I
K
W
T
A
P
E
A
A
L
Y
---
G
----
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
V
T
K
G
R
V
P
Y
P
G
M
N
N
R
--
E
V
L
E
Q
-
V
E
R
G
Y
--
R
--
M
P
-----
C
P
Q
--
D
C
P
I
S
L
H
E
L
M
I
H
C
W
K
K
D
P
E
E
R
P
T
F
E
Y
L
Q
S
F
L
E
------------------------------------------
475
Blastp_CBE
47.62
31%
-33
- C3 -
-
6B5J
6.5
-
D:
[42-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
I
E
F
H
E
I
I
G
S
G
S
F
G
K
V
------
Y
K
G
R
C
--
R
------
N
--------
K
I-----
V
A
I
K
R
Y
--------S
D
V
D
M
F
C
R
E
V
S
I
L
C
Q
L
-
N
H
P
C
V
I
Q
F
V
G
A
C
-
L
N
--
D
--
P
S
Q--
F
A
I
V
T
Q
Y
I
S
G
G
S
L
F
S
L
L
-------
H
E
-
Q
K
-
R
--
I
----------
L
---------------
D
L
Q
S
K
L
I
I
A
V
D
V
A
K
G
M
E
Y
L
H
NL
T
---
Q
P
---
I
I
H
R
D
L
N
S
H
N
I
L
L
Y
E
D
G
-------
H
A
-
V
V
A
D
F
G
E
S
--------
R
F
--
L
Q
S
-------------
G
N
L
R
W
M
A
P
E
V
--
F
T
Q
C
T
----
R
Y
T
I
K
A
D
V
F
S
Y
A
L
C
L
W
E
I
L
T
-
G
E
I
P
F
A
H
L
K
P
A
A
-
A
A
A
D
M
-
A
Y
H
H
I
--
R
--
P
P
-----
I
G
Y
--
S
I
P
K
P
I
S
S
L
L
I
R
G
W
N
A
C
P
E
G
R
P
E
F
S
E
V
V
M
K
L
E
------------------------------------------
245
Blastp_CBE
47.58
32%
-35
- C3 -
-
3AD4
5.2
-
LCK_HUMAN
A:
[14-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
R
E
T
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
------
W
M
G
Y
Y
--
N
------
G
HT------
K
------
V
A
V
K
S
L
K
Q
G
S
M
S
P
D
----
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
-
V
-
V
T
--
Q
--
E
P
---
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
-------
K
T
P
S
G
-
I
--
K
----------
L
---------------
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
--
E
---
R
N
---
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
-------
S
C
-
K
I
A
D
F
G
L
A
--------
R
L
--
I
E
D
N
E
T
A
R
----
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
---
G
----
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
-
T
N
P
-
E
V
I
Q
N
-
L
E
R
G
Y
RM
V
--
R
P
D
---------
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
------------------------------------------
471
Blastp_CBE
47.38
31%
-27
- C3 -
-
4YFI
6.1
-
D:
[61-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
I
E
F
H
E
I
I
G
S
G
S
F
G
K
V
------
Y
K
G
R
C
--
R
------
N
--------
K
I-----
V
A
I
K
R
Y
--------S
D
V
D
M
F
C
R
E
V
S
I
L
C
Q
L
-
N
H
P
C
V
I
Q
F
V
G
A
C
-
L
N
--
D
--
P
S
Q--
F
A
I
V
T
Q
Y
I
S
G
G
S
L
F
S
L
L
-------
H
E
-
Q
K
-
R
--
I
----------
L
---------------
D
L
Q
S
K
L
I
I
A
V
D
V
A
K
G
M
E
Y
L
H
NL
T
---
Q
P
---
I
I
H
R
D
L
N
S
H
N
I
L
L
Y
E
D
G
-------
H
A
-
V
V
A
D
F
G
E
S
--------
R
F
--
L
Q
S
-------------
G
N
L
R
W
M
A
P
E
V
--
F
T
Q
C
T
----
R
Y
T
I
K
A
D
V
F
S
Y
A
L
C
L
W
E
I
L
T
-
G
E
I
P
F
A
H
L
K
P
A
A
-
A
D
M
D
M
-
A
Y
H
H
I
--
R
--
P
P
-----
I
G
Y
--
S
I
P
K
P
I
S
S
L
L
I
R
G
W
N
A
C
P
E
G
R
P
E
F
S
E
V
V
M
K
L
E
------------------------------------------
474
Blastp_CBE
47.15
31%
-28
- C3 -
-
4YFI
6.5
-
TNI3K_HUMAN
A:
[61-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
I
E
F
H
E
I
I
G
S
G
S
F
G
K
V
------
Y
K
G
R
C
--
R
------
N
--------
K
I-----
V
A
I
K
R
Y
R
-------S
D
V
D
M
F
C
R
E
V
S
I
L
C
Q
L
-
N
H
P
C
V
I
Q
F
V
G
A
C
-
L
N
--
D
--
P
S
Q--
F
A
I
V
T
Q
Y
I
S
G
G
S
L
F
S
L
L
-------
H
E
-
Q
K
-
R
--
I
----------
L
---------------
D
L
Q
S
K
L
I
I
A
V
D
V
A
K
G
M
E
Y
L
H
NL
T
---
Q
P
---
I
I
H
R
D
L
N
S
H
N
I
L
L
Y
E
D
G
-------
H
A
-
V
V
A
D
F
G
E
S
--------
R
F
--
L
Q
--------------
G
N
L
R
W
M
A
P
E
V
--
F
T
Q
C
T
----
R
Y
T
I
K
A
D
V
F
S
Y
A
L
C
L
W
E
I
L
T
-
G
E
I
P
F
A
H
L
K
P
A
A
-
A
D
M
D
M
-
A
Y
H
H
I
--
R
--
P
P
-----
I
G
Y
--
S
I
P
K
P
I
S
S
L
L
I
R
G
W
N
A
C
P
E
G
R
P
E
F
S
E
V
V
M
K
L
E
------------------------------------------
477
Blastp_CBE
47.02
31%
-27
- C3 -
-
6B5J
6.1
-
TNI3K_HUMAN
B:
[42-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
I
E
F
H
E
I
I
G
S
G
S
F
G
K
V
------
Y
K
G
R
C
--
R
------
N
--------
K
I-----
V
A
I
K
R
Y
R
------
K
S
D
V
D
M
F
C
R
E
V
S
I
L
C
Q
L
-
N
H
P
C
V
I
Q
F
V
G
A
C
-
L
N
--
D
--
P
S
Q--
F
A
I
V
T
Q
Y
I
S
G
G
S
L
F
S
L
L
-------
H
E
-
Q
K
-
R
--
I
----------
L
---------------
D
L
Q
S
K
L
I
I
A
V
D
V
A
K
G
M
E
Y
L
H
NL
T
---
Q
P
---
I
I
H
R
D
L
N
S
H
N
I
L
L
Y
E
D
G
-------
H
A
-
V
V
A
D
F
G
E
S
--------
R
F
--
L
Q
---------------
N
L
R
W
M
A
P
E
V
--
F
T
Q
C
T
----
R
Y
T
I
K
A
D
V
F
S
Y
A
L
C
L
W
E
I
L
T
-
G
E
I
P
F
A
H
L
K
P
A
A
-
A
A
A
D
M
-
A
Y
H
H
I
--
R
--
P
P
-----
I
G
Y
--
S
I
P
K
P
I
S
S
L
L
I
R
G
W
N
A
C
P
E
G
R
P
E
F
S
E
V
V
M
K
L
E
------------------------------------------
480
Blastp_CBE
46.90
31%
-22
- C3 -
-
4YFF
6.0
-
TNI3K_HUMAN
C:
[42-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
I
E
F
H
E
I
I
G
S
G
S
F
G
K
V
------
Y
K
G
R
C
--
R
------
N
--------
K
I-----
V
A
I
K
R
Y
--------S
D
V
D
M
F
C
R
E
V
S
I
L
C
Q
L
-
N
H
P
C
V
I
Q
F
V
G
A
C
-
L
N
--
D
--
P
S
Q--
F
A
I
V
T
Q
Y
I
S
G
G
S
L
F
S
L
L
-------
H
E
-
Q
K
-
R
--
I
----------
L
---------------
D
L
Q
S
K
L
I
I
A
V
D
V
A
K
G
M
E
Y
L
H
NL
T
---
Q
P
---
I
I
H
R
D
L
N
S
H
N
I
L
L
Y
E
D
G
-------
H
A
-
V
V
A
D
F
G
E
S
--------
R
F
--
L
Q
S
----------
Q
P
-
G
N
L
R
W
M
A
P
E
V
--
F
T
Q
C
T
----
R
Y
T
I
K
A
D
V
F
S
Y
A
L
C
L
W
E
I
L
T
-
G
E
I
P
F
A
H
L
K
P
A
A
-
A
A
A
D
M
-
A
Y
H
H
I
--
R
--
P
P
-----
I
G
Y
--
S
I
P
K
P
I
S
S
L
L
I
R
G
W
N
A
C
P
E
G
R
P
E
F
S
E
V
V
M
K
L
E
------------------------------------------
472
Blastp_CBE
46.73
31%
-29
- C3 -
-
4YFI
6.4
-
TNI3K_HUMAN
C:
[61-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
I
E
F
H
E
I
I
G
S
G
S
F
G
K
V
------
Y
K
G
R
C
--
R
------
N
--------
K
I-----
V
A
I
K
R
Y
R
-------S
D
V
D
M
F
C
R
E
V
S
I
L
C
Q
L
-
N
H
P
C
V
I
Q
F
V
G
A
C
-
L
N
--
D
--
P
S
Q--
F
A
I
V
T
Q
Y
I
S
G
G
S
L
F
S
L
L
-------
H
E
-
Q
K
-
R
--
I
----------
L
---------------
D
L
Q
S
K
L
I
I
A
V
D
V
A
K
G
M
E
Y
L
H
NL
T
---
Q
P
---
I
I
H
R
D
L
N
S
H
N
I
L
L
Y
E
D
G
-------
H
A
-
V
V
A
D
F
G
E
S
--------
R
F
--
L
Q
S
-------------
G
N
L
R
W
M
A
P
E
V
--
F
T
Q
C
T
----
R
Y
T
I
K
A
D
V
F
S
Y
A
L
C
L
W
E
I
L
T
-
G
E
I
P
F
A
H
L
K
P
A
A
-
A
D
M
D
M
-
A
Y
H
H
I
--
R
--
P
P
-----
I
G
Y
--
S
I
P
K
P
I
S
S
L
L
I
R
G
W
N
A
C
P
E
G
R
P
E
F
S
E
V
V
M
K
L
E
------------------------------------------
481
Blastp_CBE
46.49
31%
-25
- C3 -
-
4YFF
5.9
-
TNI3K_HUMAN
B:
[42-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
I
E
F
H
E
I
I
G
S
G
S
F
G
K
V
------
Y
K
G
R
C
--
R
------
N
--------
K
I-----
V
A
I
K
R
Y
R
------
K
S
D
V
D
M
F
C
R
E
V
S
I
L
C
Q
L
-
N
H
P
C
V
I
Q
F
V
G
A
C
-
L
N
--
D
--
P
S
Q--
F
A
I
V
T
Q
Y
I
S
G
G
S
L
F
S
L
L
-------
H
E
-
Q
K
-
R
--
I
----------
L
---------------
D
L
Q
S
K
L
I
I
A
V
D
V
A
K
G
M
E
Y
L
H
NL
T
---
Q
P
---
I
I
H
R
D
L
N
S
H
N
I
L
L
Y
E
D
G
-------
H
A
-
V
V
A
D
F
G
E
S
--------
R
F
--
L
Q
---------------
N
L
R
W
M
A
P
E
V
--
F
T
Q
C
T
----
R
Y
T
I
K
A
D
V
F
S
Y
A
L
C
L
W
E
I
L
T
-
G
E
I
P
F
A
H
L
K
P
A
A
-
A
A
A
D
M
-
A
Y
H
H
I
--
R
--
P
P
-----
I
G
Y
--
S
I
P
K
P
I
S
S
L
L
I
R
G
W
N
A
C
P
E
G
R
P
E
F
S
E
V
V
M
K
L
E
------------------------------------------
473
Blastp_CBE
46.47
31%
-25
- C3 -
-
4YFI
6.0
-
TNI3K_HUMAN
B:
[61-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
I
E
F
H
E
I
I
G
S
G
S
F
G
K
V
------
Y
K
G
R
C
--
R
------
N
--------
K
I-----
V
A
I
K
R
Y
R
-------S
D
V
D
M
F
C
R
E
V
S
I
L
C
Q
L
-
N
H
P
C
V
I
Q
F
V
G
A
C
-
L
N
--
D
--
P
S
Q--
F
A
I
V
T
Q
Y
I
S
G
G
S
L
F
S
L
L
-------
H
E
-
Q
K
-
R
--
I
----------
L
---------------
D
L
Q
S
K
L
I
I
A
V
D
V
A
K
G
M
E
Y
L
H
NL
T
---
Q
P
---
I
I
H
R
D
L
N
S
H
N
I
L
L
Y
E
D
G
-------
H
A
-
V
V
A
D
F
G
E
S
--------
R
F
--
L
Q
S
-------------
G
N
L
R
W
M
A
P
E
V
--
F
T
Q
C
T
----
R
Y
T
I
K
A
D
V
F
S
Y
A
L
C
L
W
E
I
L
T
-
G
E
I
P
F
A
H
L
K
P
A
A
-
A
D
M
D
M
-
A
Y
H
H
I
--
R
--
P
P
-----
I
G
Y
--
S
I
P
K
P
I
S
S
L
L
I
R
G
W
N
A
C
P
E
G
R
P
E
F
S
E
V
V
M
K
L
E
------------------------------------------
180
Blastp_CBE
46.43
32%
-17
- C3 -
-
3A4O
4.7
-
LYN_HUMAN
X:
[8-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
R
E
S
I
K
L
V
K
R
L
G
A
G
Q
F
G
E
V
------
W
M
G
Y
Y
--
N
------
N
--------
S
TK----
V
A
V
K
T
L
K
---
P
G
T
M
-
S
V
Q
A
F
L
E
E
A
N
L
M
K
T
L
-
Q
H
D
K
L
V
R
L
Y
A
-
V
-
V
T
--
R
--
E
E
P--
I
Y
I
I
T
E
Y
M
A
K
G
S
L
L
D
F
L
-------
K
S
-
D
E
-
G
G-
K
----------
V
---------------
L
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
--
R
---
K
N
---
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
-------
M
C
-
K
I
A
D
F
G
L
A
--------
R
V
---------
E
--
G
A
K
F
P
---
I
K
W
T
A
P
E
A
I
N
F
---
G
----
C
F
T
I
K
S
D
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
T
N
A
D
--
V
M
T
A
-
L
S
Q
G
Y
--
R
--
M
P
R
V
-----
E
--
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
------------------------------------------
479
Blastp_CBE
46.34
31%
-27
- C3 -
-
4YFF
6.2
-
D:
[42-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
I
E
F
H
E
I
I
G
S
G
S
F
G
K
V
------
Y
K
G
R
C
--
R
------
N
--------
K
I-----
V
A
I
K
R
Y
--------S
D
V
D
M
F
C
R
E
V
S
I
L
C
Q
L
-
N
H
P
C
V
I
Q
F
V
G
A
C
-
L
N
--
D
--
P
S
Q--
F
A
I
V
T
Q
Y
I
S
G
G
S
L
F
S
L
L
-------
H
E
-
Q
K
-
R
--
I
----------
L
---------------
D
L
Q
S
K
L
I
I
A
V
D
V
A
K
G
M
E
Y
L
H
NL
T
---
Q
P
---
I
I
H
R
D
L
N
S
H
N
I
L
L
Y
E
D
G
-------
H
A
-
V
V
A
D
F
G
E
S
--------
R
F
--
L
Q
S
-------------
G
N
L
R
W
M
A
P
E
V
--
F
T
Q
C
T
----
R
Y
T
I
K
A
D
V
F
S
Y
A
L
C
L
W
E
I
L
T
-
G
E
I
P
F
A
H
L
K
P
A
A
-
A
A
A
D
M
-
A
Y
H
H
I
--
R
--
P
P
-----
I
G
Y
--
S
I
P
K
P
I
S
S
L
L
I
R
G
W
N
A
C
P
E
G
R
P
E
F
S
E
V
V
M
K
L
E
------------------------------------------
482
Blastp_CBE
45.40
31%
-22
- C3 -
-
4YFF
5.5
-
TNI3K_HUMAN
A:
[42-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
I
E
F
H
E
I
I
G
S
G
S
F
G
K
V
------
Y
K
G
R
C
--
R
------
N
--------
K
I-----
V
A
I
K
R
Y
R
-------S
D
V
D
M
F
C
R
E
V
S
I
L
C
Q
L
-
N
H
P
C
V
I
Q
F
V
G
A
C
-
L
N
--
D
--
P
S
Q--
F
A
I
V
T
Q
Y
I
S
G
G
S
L
F
S
L
L
-------
H
E
-
Q
K
-
R
--
I
----------
L
---------------
D
L
Q
S
K
L
I
I
A
V
D
V
A
K
G
M
E
Y
L
H
NL
T
---
Q
P
---
I
I
H
R
D
L
N
S
H
N
I
L
L
Y
E
D
G
-------
H
A
-
V
V
A
D
F
G
E
S
--------
R
F
--
L
Q
S
--------------
N
L
R
W
M
A
P
E
V
--
F
T
Q
C
T
----
R
Y
T
I
K
A
D
V
F
S
Y
A
L
C
L
W
E
I
L
T
-
G
E
I
P
F
A
H
L
K
P
A
A
-
A
A
A
D
M
-
A
Y
H
H
I
--
R
--
P
P
-----
I
G
Y
--
S
I
P
K
P
I
S
S
L
L
I
R
G
W
N
A
C
P
E
G
R
P
E
F
S
E
V
V
M
K
L
E
------------------------------------------
519
Blastp_CBE
33.50
33%
-6
- C3 -
-
4JIA
2.8
-
A:
[17-217]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
------
E
M
C
R
Y
--
D
PLQDNT
G
--------
E
------
V
-
V
A
V
K
K
L
Q
H
S
T
E
E
-
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
-
Q
H
D
N
I
V
K
Y
K
G
-
V
-
C
Y
--
S
--
A
G
RRN
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
-------
Q
K
-
H
K
-
E
--
R
----------
I
---------------
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
--
T
---
K
R
---
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
-------
R
V
-
K
I
G
D
F
G
L
T
--------
K
V
LP
Q
D
K
E
K
V
K
E
--
P
G
E
S
P
---
I
F
W
Y
A
P
E
S
L
---
T
E
S
----
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
--------------------------------------------------------------------------------------------------------------------
512
Blastp_CBE
31.94
33%
8
- C3 -
-
4E6D
3.2
-
B:
[15-215]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
F
L
R
Q
L
G
K
G
N
F
G
S
V
------
E
M
C
R
Y
--
D
PLQDNT
G
--------
E
------
V
-
V
A
V
K
K
L
Q
H
S
T
E
E
-
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
-
Q
H
D
N
I
V
K
Y
K
G
-
V
-
C
Y
-------N--
L
K
L
I
M
E
F
L
P
Y
G
S
L
R
E
Y
L
-------
Q
K
-
H
K
-
E
--
R
----------
I
---------------
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
--
T
---
K
R
---
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
-------
R
V
-
K
I
G
D
F
G
L
T
--------
K
V
LP
Q
D
K
E
K
V
K
E
--
P
G
E
S
P
---
I
F
W
Y
A
P
E
S
L
---
T
E
S
----
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
--------------------------------------------------------------------------------------------------------------------