@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Screening
Virtual Screening Score
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ARBK2_HUMAN: (2020-09-04 )
MADLEAVLADVSYLMAMEKSKATPAARASKRIVLPEPSIRSVMQKYLAERNEITFDKIFNQKIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKELLSCSHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNVELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDCDQELYKNFPLVISERWQQEVTETVYEAVNADTDKIEARKRAKNKQLGHEEDYALGKDCIMHGYMLKLGNPFLTQWQRRYFYLFPNRLEWRGEGESRQNLLTMEQILSVEETQIKDKKCILFRIKGGKQFVLQCESDPEFVQWKKELNETFKEAQRLLRRAPKFLNKPRSGTVELPKPSLCHRNSNGL
Atome Classification :
(145 SA)
.........10........20..--...---...30--.---........40.--......-.50.......-.-60.........70........80.----..----.....90........100.......110.....-..120.......130.......140.......150.......160.......170.......180.......190.......200.......210-.---........220.....-..230......-.240.......250.......260.......270.......280-...----..----.--.--.--.290.......300.......310........320.......330......---.----340--.--.---.-.--.--.-.-.350-.--...-----.....360........370.......380.......390.....-..-400..------......410.......420-.......430.......-440........450.......460.......470.......480.......490-..-.-.----------..---..500----.........-510-........520..-.....530.......540.......550.......560.......570.......580.......590.......600.......-610.-........620.......630.......640.......650.......660.......670.......680......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(pKd)
(pKd)
(Uniprot)
MA
D
L
E
A
V
L
A
D
V
S
Y
L
M
A
M
E
KSKAT--PAA---RAS
K
---
R
---
I
VLP
E
P
S
I
R
S
V
--
M
Q
K
Y
L
A
-ERNEI
T
F
D
K
I
-
F
-
N
-QK
I
G
F
L
L
F
K
D
F
C
L
N
E
I
N
E
AVP
Q
----
V
K
----
F
Y
E
E
I
K
E
Y
E
K
LD
N
E
E
D
R
L
C
R
SR
Q
I
Y
D
A
Y
I
M
K
E
L
-
L
SCSHP
F
S
K
Q
A
V
E
H
V
Q
S
H
L
S
K
K
Q
V
T
S
T
L
F
Q
P
Y
I
E
E
I
C
E
S
L
R
G
D
I
F
Q
K
F
M
ESDKF
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
MNEF
S
V
H
R
I
IGRGGFGEVYGCRK---A---DTG
K
M
Y
A
M
K
C
L
D
K
K
R
I
-KMKQG
E
T
L
ALN-
E
R
I
M
L
S
L
VSTGDC
P
F
I
V
C
M
T
Y
AFHTPD
K
L
C
F
I
L
DLMNGG
D
L
H
---
Y
H
L
----
S
Q----H--G--V--F
S
E
K
E
M
R
F
Y
A
T
E
I
I
L
G
L
E
H
MHN-
R
F
V
V
Y
R
DLK
P
A
N
I
L
LDEHGH
A
R
ISDLGL---A----C-D--F--S---K-K--K--P-H-AS---V--GTH-----GYM
A
P
E
-
V
L
Q
KGTAYDSSA
D
W
F
S
L
G
C
M
L
F
K
L
L
RGHS
P
F
R
QHKTK-
D
K
-H-EI
D
------
R
M
T
L
T
V
N
V
ELPDTF
S
P
E
L
K
-
S
L
L
E
G
L
L
Q
R
D
V
S
K
R
LGC-HG-G
G
S
Q
E
V
K
E
HSFFKGVD
W
Q
H
V
Y
L
QKYPPPLIPPRGEVNAADAFDIGSFDEE--DT-K-G----------
I
K
---
L
LD------C
D
Q
E
L
Y
K
NF-
P
-
L
-
V
I
S
E
R
W
Q
Q
E
V
T
E
T
-
V
Y
E
A
VNAD
T
D
K
I
E
A
R
K
RAKNKQLGHEEDYAL
G
K
D
C
I
M
H
G
Y
M
L
KLG
N
P
F
L
T
Q
W
Q
R
R
Y
F
Y
LFPN
R
L
E
WRGEGE
S
R
Q
N
L
L
T
M
E
Q
I
L
S
V
-
E
--
E
-TQIKDK
K
C
I
L
F
R
IKGG
K
Q
F
V
L
Q
CESD
P
E
F
V
Q
W
K
K
E
L
N
E
T
F
K
E
A
Q
R
L
L
R
R
A
P
K
F
LNKPRSG
T
V
ELPK
P
S
L
CHRNSNGL
21
Blastp_CBE
97.29
84%
-110
- C1 -
-
5UKL
8.7
-
ARBK1_HUMAN
A:
[2-641]
--------------------------------------
K
---
I
L
L
P
E
P
S
I
R
S
V
--
M
Q
K
Y
L
E
-
D
R
G
E
V
T
F
E
K
I
-
F
-
S
-
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
H
L
E
E
A
R
P
L
----
V
E
----
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
-
L
A
C
S
H
P
F
S
K
S
A
T
E
H
V
Q
G
H
L
G
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
---
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
-
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
----
S
Q
----
H
--
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
----
C
-
D
--
F
--
S
---
K
-
K
--
K
--
P
-
H
-
A
S
---
V
--
G
T
H
-----
G
Y
M
A
P
E
-
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
-
D
K
-
H
-
E
I
D
------
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
-
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
E
V
N
A
A
D
A
F
D
-------------------------
I
K
---
L
L
D
------
S
D
Q
E
L
Y
R
N
F
-
P
-
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
N
P
F
L
T
Q
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
-
E
--
E
-
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
I
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
R
A
------------------
2
PsiBlast_PDB
96.95
84%
-109
- C1 -
-
3V5W
6.8
-
ARBK1_HUMAN
A:
[30-668]
----------------------------------
K
---
K
---
I
L
L
P
E
P
S
I
R
S
V
--
M
Q
K
Y
L
E
-
D
R
G
E
V
T
F
E
K
I
-
F
-
S
-
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
H
L
E
E
A
R
P
L
----
V
E
----
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
-
L
A
C
S
H
P
F
S
K
S
A
T
E
H
V
Q
G
H
L
G
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
---
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
-
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
----
S
Q
----
H
--
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
----
C
-
D
--
F
--
S
---
K
-
K
--
K
--
P
-
H
-
A
S
---
V
--
G
T
H
-----
G
Y
M
A
P
E
-
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
-
D
K
-
H
-
E
I
D
------
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
-
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
E
V
N
A
A
D
A
F
D
------------
K
-
G
----------
I
K
---
L
L
D
------
S
D
Q
E
L
Y
R
N
F
-
P
-
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
-------
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
-
E
--
E
-
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
I
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
--------------------
22
Blastp_CBE
96.66
84%
-106
- C1 -
-
4MK0
6.8
-
ARBK1_HUMAN
A:
[1-639]
----------------------------------
K
---
K
---
I
L
L
P
E
P
S
I
R
S
V
--
M
Q
K
Y
L
E
-
D
R
G
E
V
T
F
E
K
I
-
F
-
S
-
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
H
L
E
E
A
R
P
L
----
V
E
----
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
-
L
A
C
S
H
P
F
S
K
S
A
T
E
H
V
Q
G
H
L
G
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
---
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
-
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
----
S
Q
----
H
--
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
----
C
-
D
--
F
--
S
---
K
-
K
--
K
--
P
-
H
-
A
S
---
V
--
G
T
H
-----
G
Y
M
A
P
E
-
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
-
D
K
-
H
-
E
I
D
------
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
-
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
E
V
N
A
A
D
A
F
-----------
T
-
K
-
G
----------
I
K
---
L
L
D
------
S
D
Q
E
L
Y
R
N
F
-
P
-
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
N
P
F
L
T
Q
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
-
E
--
E
-
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
I
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
--------------------
24
Blastp_CBE
95.99
84%
-105
- C1 -
-
5HE2
8.4
-
ARBK1_BOVIN
A:
[1-639]
----------------------------------
K
---
K
---
I
L
L
P
E
P
S
I
R
S
V
--
M
Q
K
Y
L
E
-
D
R
G
E
V
T
F
E
K
I
-
F
-
S
-
Q
K
L
G
Y
L
L
F
R
D
F
C
L
K
H
L
E
E
A
K
P
L
----
V
E
----
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
L
V
C
S
R
E
I
F
D
T
Y
I
M
K
E
L
-
L
A
C
S
H
P
F
S
K
S
A
I
E
H
V
Q
G
H
L
V
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
---
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
-
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
----
S
Q
----
H
--
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
----
C
-
D
--
F
--
S
---
K
-
K
--
K
--
P
-
H
-
A
S
---
V
--
G
T
H
-----
G
Y
M
A
P
E
-
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
-
D
K
-
H
-
E
I
D
------
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
-
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
-----------
G
S
F
D
E
E
--
D
T
-
K
-
G
----------
I
K
---
L
L
D
------
S
D
Q
E
L
Y
R
N
F
-
P
-
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
T
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
N
P
F
L
T
Q
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
-
E
--
E
-
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
V
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
--------------------
8
PsiBlast_PDB
95.90
84%
-109
- C1 -
-
3KRW
7.0
-
ARBK1_HUMAN
A:
[29-670]
----------------------------------
K
---
K
---
I
L
L
P
E
P
S
I
R
S
V
--
M
Q
K
Y
L
E
-
D
R
G
E
V
T
F
E
K
I
-
F
-
S
-
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
H
L
E
E
A
R
P
L
----
V
E
----
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
-
L
A
--
H
P
F
S
K
S
A
T
E
H
V
Q
G
H
L
G
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
---
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
-
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
----
S
Q
----
H
--
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
----
C
-
D
--
F
--
S
---
K
-
K
--
K
--
P
-
H
-
A
S
---
V
--
G
T
H
-----
G
Y
M
A
P
E
-
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
-
D
K
-
H
-
E
I
D
------
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
-
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
---------------
E
E
--
D
T
-
K
-
G
----------
I
K
---
L
L
D
------
S
D
Q
E
L
Y
R
N
F
-
P
-
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
-------
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
-
E
--
E
-
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
I
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
R
S
P
-----------------
25
Blastp_CBE
95.73
84%
-109
- C1 -
-
5HE0
8.5
-
ARBK1_BOVIN
A:
[1-639]
----------------------------------
K
---
K
---
I
L
L
P
E
P
S
I
R
S
V
--
M
Q
K
Y
L
E
-
D
R
G
E
V
T
F
E
K
I
-
F
-
S
-
Q
K
L
G
Y
L
L
F
R
D
F
C
L
K
H
L
E
E
A
K
P
L
----
V
E
----
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
L
V
C
S
R
E
I
F
D
T
Y
I
M
K
E
L
-
L
A
C
S
H
P
F
S
K
S
A
I
E
H
V
Q
G
H
L
V
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
---
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
-
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
----
S
Q
----
H
--
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
----
C
-
D
--
F
--
S
---
K
-
K
--
K
--
P
-
H
-
A
S
---
V
--
G
T
H
-----
G
Y
M
A
P
E
-
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
-
D
K
-
H
-
E
I
D
------
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
-
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
---------------------
K
-
G
----------
I
K
---
L
L
D
------
S
D
Q
E
L
Y
R
N
F
-
P
-
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
T
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
N
P
F
L
T
Q
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
-
E
--
E
-
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
V
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
--------------------
3
PsiBlast_PDB
95.58
84%
-105
- C1 -
-
4PNK
5.6
-
ARBK1_HUMAN
A:
[30-668]
----------------------------------
K
---
K
---
I
L
L
P
E
P
S
I
R
S
V
--
M
Q
K
Y
L
E
-
D
R
G
E
V
T
F
E
K
I
-
F
-
S
-
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
H
L
E
E
A
R
P
L
----
V
E
----
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
-
L
A
C
S
H
P
F
S
K
S
A
T
E
H
V
Q
G
H
L
G
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
---
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
-
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
----
S
Q
----
H
--
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
----
C
-
D
--
F
--
S
---
K
-
K
--
K
--
P
-
H
-
A
S
---
V
--
G
T
H
-----
G
Y
M
A
P
E
-
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
-
D
K
-
H
-
E
I
D
------
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
-
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
-
E
V
N
A
---------------
T
-
K
-
G
----------
I
K
---
L
L
D
------
S
D
Q
E
L
Y
R
N
F
-
P
-
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
N
P
F
L
T
Q
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
-
E
--
E
-
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
I
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
--------------------
7
PsiBlast_PDB
95.46
83%
-110
- C1 -
-
6C2Y
7.4
-
ARBK1_HUMAN
A:
[30-668]
----------------------------------
K
---
K
---
I
L
L
P
E
P
S
I
R
S
V
--
M
Q
K
Y
L
E
-
D
R
G
E
V
T
F
E
K
I
-
F
-
S
-
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
H
L
E
E
A
R
P
L
----
V
E
----
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
-
L
A
C
S
H
P
F
S
K
S
A
T
E
H
V
Q
G
H
L
G
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
---
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
-
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
----
S
Q
----
H
--
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
----
C
-
D
--
F
--
S
---
K
-
K
--
K
--
P
-
H
-
A
S
---
V
--
G
T
H
-----
G
Y
M
A
P
E
-
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
-
D
K
-
H
-
E
I
D
------
R
M
T
L
--
A
V
E
L
P
D
S
F
S
P
E
L
R
-
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
--------------------
T
-
K
-
G
----------
I
K
---
L
L
D
------
S
D
Q
E
L
Y
R
N
F
-
P
-
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
N
K
Q
L
G
--
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
N
P
F
L
T
Q
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
-
E
--
E
-
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
I
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
--------------------
9
PsiBlast_PDB
95.03
84%
-106
- C1 -
-
3KRX
7.8
-
ARBK1_HUMAN
A:
[29-670]
----------------------------------
K
---
K
---
I
L
L
P
E
P
S
I
R
S
V
--
M
Q
K
Y
L
E
-
D
R
G
E
V
T
F
E
K
I
-
F
-
S
-
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
H
L
E
E
A
R
P
L
----
V
E
----
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
-
L
A
--
H
P
F
S
K
S
A
T
E
H
V
Q
G
H
L
G
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
---
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
-
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
----
S
Q
----
H
--
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
----
C
-
D
--
F
--
S
---
K
-
K
--
K
--
P
-
H
-
A
S
---
V
--
G
T
H
-----
G
Y
M
A
P
E
-
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
-
D
K
-
H
-
E
I
D
------
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
-
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
---------------
E
E
--
D
T
-
K
-
G
----------
I
K
---
L
L
D
------
S
D
Q
E
L
Y
R
N
F
-
P
-
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
-------
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
-
E
--
E
-
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
I
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
R
S
P
-----------------
19
PsiBlast_PDB
94.62
84%
-110
- C1 -
-
5HE1
9.3
-
ARBK1_HUMAN
A:
[1-640]
---------------------------------
S
K
---
K
---
I
L
L
P
E
P
S
I
R
S
V
--
M
Q
K
Y
L
E
-
D
R
G
E
V
T
F
E
K
I
-
F
-
S
-
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
H
L
E
E
A
R
P
L
----
V
E
----
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
-
L
A
C
S
H
P
F
S
K
S
A
T
E
H
V
Q
G
H
L
G
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
---
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
-
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
----
S
Q
----
H
--
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
----
C
-
D
--
F
--
S
---
K
-
K
--
K
--
P
-
H
-
A
S
---
V
--
G
T
H
-----
G
Y
M
A
P
E
-
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
-
D
K
-
H
-
E
I
D
------
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
-
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
---------------------
T
-
K
-
G
----------
I
K
---
L
L
D
------
S
D
Q
E
L
Y
R
N
F
-
P
-
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
N
K
---
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
N
P
F
L
T
Q
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
-
E
--
E
-
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
I
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
--------------------
23
Blastp_CBE
94.51
84%
-106
- C1 -
-
5HE3
7.3
-
ARBK1_BOVIN
A:
[1-641]
----------------------------------
K
---
K
---
I
L
L
P
E
P
S
I
R
S
V
--
M
Q
K
Y
L
E
-
D
R
G
E
V
T
F
E
K
I
-
F
-
S
-
Q
K
L
G
Y
L
L
F
R
D
F
C
L
K
H
L
E
E
A
K
P
L
----
V
E
----
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
L
V
C
S
R
E
I
F
D
T
Y
I
M
K
E
L
-
L
A
C
S
H
P
F
S
K
S
A
I
E
H
V
Q
G
H
L
V
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
---
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
-
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
----
S
Q
----
H
--
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
----
C
-
D
--
F
--
S
---
K
-
K
--
K
--
P
-
H
-
A
S
---
V
--
G
T
H
-----
G
Y
M
A
P
E
-
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
-
D
K
-
H
-
E
I
D
------
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
-
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
--------------------
T
-
K
-
G
----------
I
K
---
L
L
D
------
S
D
Q
E
L
Y
R
N
F
-
P
-
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
T
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
N
P
F
L
T
Q
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
-
E
--
E
-
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
V
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
R
S
------------------
549
HHSearch
94.45
83%
-94
- C1 -
-
5UKL
8.7
-
ARBK1_HUMAN
A:
[2-641]
--------------------------------------
K
---
I
L
L
P
E
P
S
I
R
S
V
--
M
Q
K
Y
L
E
-
D
R
G
E
V
T
F
E
K
I
-
F
-
S
-
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
H
L
E
E
A
R
P
L
----
V
E
----
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
-
L
A
C
S
H
P
F
S
K
S
A
T
E
H
V
Q
G
H
L
G
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
---
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
-
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
----
S
Q
----
H
--
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
----
C
-
D
--
F
--
S
---
K
-
K
--
K
--
P
-
H
-
A
S
---
V
--
G
T
H
-----
G
Y
M
A
P
E
-
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
-
D
K
-
H
-
E
I
D
------
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
-
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
E
V
N
A
A
D
A
F
D
-------------------------
I
K
---
L
L
D
------
S
D
Q
E
L
Y
R
N
F
-
P
-
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
N
P
F
L
T
Q
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
---
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V-
E
E
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
I
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
R
A
------------------
18
PsiBlast_PDB
94.41
83%
-107
- C1 -
-
5UKM
8.1
-
ARBK1_BOVIN
A:
[31-669]
--------------------------------------
K
---
I
L
L
P
E
P
S
I
R
S
V
--
M
Q
K
Y
L
E
-
D
R
G
E
V
T
F
E
K
I
-
F
-
S
-
Q
K
L
G
Y
L
L
F
R
D
F
C
L
K
H
L
E
E
A
K
P
L
----
V
E
----
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
L
V
C
S
R
E
I
F
D
T
Y
I
M
K
E
L
-
L
A
C
S
H
P
F
S
K
S
A
I
E
H
V
Q
G
H
L
V
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
---
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
-
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
----
S
Q
----
H
--
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
----
C
-
D
--
F
--
S
---
K
-
K
--
K
--
P
-
H
-
A
S
---
V
--
G
T
H
-----
G
Y
M
A
P
E
-
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
-
D
K
-
H
-
E
I
D
------
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
-
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
E
V
N
A
A
D
A
F
D
-------------------------
I
K
---
L
L
D
------
S
D
Q
E
L
Y
R
N
F
-
P
-
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
T
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
-------
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
-
E
--
E
-
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
V
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
R
-------------------
16
PsiBlast_PDB
94.23
83%
-115
- C1 -
-
3PVU
8.5
-
ARBK1_BOVIN
A:
[30-668]
----------------------------------
K
---
K
---
I
L
L
P
E
P
S
I
R
S
V
--
M
Q
K
Y
L
E
-
D
R
G
E
V
T
F
E
K
I
-
F
-
S
-
Q
K
L
G
Y
L
L
F
R
D
F
C
L
K
H
L
E
E
A
K
P
L
----
V
E
----
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
L
V
C
S
R
E
I
F
D
T
Y
I
M
K
E
L
-
L
A
C
S
H
P
F
S
K
S
A
I
E
H
V
Q
G
H
L
V
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
---
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
-
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
----
S
Q
----
H
--
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
----
C
-
D
--
F
--
S
---
K
-
K
--
K
--
P
-
H
-
A
S
---
V
--
G
T
H
-----
G
Y
M
A
P
E
-
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
-
D
K
-
H
-
E
I
D
------
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
-
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
-----------------------------------------
D
------
S
D
Q
E
L
Y
R
N
F
-
P
-
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
T
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
------
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
-
E
--
E
-
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
V
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
--------------------
6
PsiBlast_PDB
94.10
84%
-107
- C1 -
-
5WG5
6.6
-
ARBK1_HUMAN
A:
[30-668]
----------------------------------
K
---
K
---
I
L
L
P
E
P
S
I
R
S
V
--
M
Q
K
Y
L
E
-
D
R
G
E
V
T
F
E
K
I
-
F
-
S
-
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
H
L
E
E
A
R
P
L
----
V
E
----
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
-
L
A
C
S
H
P
F
S
K
S
A
T
E
H
V
Q
G
H
L
G
----
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
---
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
-
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
----
S
Q
----
H
--
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
----
C
-
D
--
F
--
S
---
K
-
K
--
K
--
P
-
H
-
A
S
---
V
--
G
T
H
-----
G
Y
M
A
P
E
-
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
-
D
K
-
H
-
E
I
D
------
R
M
T
L
---
V
E
L
P
D
S
F
S
P
E
L
R
-
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
---
V
N
A
A
D
A
F
----------
D
T
-
K
-
G
----------
I
K
---
L
L
D
------
S
D
Q
E
L
Y
R
N
F
-
P
-
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
N
K
Q
L
----
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
N
P
F
L
T
Q
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
-
E
--
E
-
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
I
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
--------------------
17
PsiBlast_PDB
94.09
83%
-111
- C1 -
-
3PVW
8.9
-
ARBK1_BOVIN
A:
[29-668]
---------------------------------
S
K
---
K
---
I
L
L
P
E
P
S
I
R
S
V
--
M
Q
K
Y
L
E
-
D
R
G
E
V
T
F
E
K
I
-
F
-
S
-
Q
K
L
G
Y
L
L
F
R
D
F
C
L
K
H
L
E
E
A
K
P
L
----
V
E
----
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
L
V
C
S
R
E
I
F
D
T
Y
I
M
K
E
L
-
L
A
C
S
H
P
F
S
K
S
A
I
E
H
V
Q
G
H
L
V
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
---
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
-
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
----
S
Q
----
H
--
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
----
C
-
D
--
F
--
S
---
K
-
K
--
K
--
P
-
H
-
A
S
---
V
--
G
T
H
-----
G
Y
M
A
P
E
-
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
-
D
K
-
H
-
E
I
D
------
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
-
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
-----------------------------------
K
---
L
L
D
------
S
D
Q
E
L
Y
R
N
F
-
P
-
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
T
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
------
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
-
E
--
E
-
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
V
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
--------------------
12
PsiBlast_PDB
94.05
83%
-106
- C1 -
-
2BCJ
-
-
ARBK1_BOVIN (first)
A:
[28-667]
--------------------------------
A
S
K
---
K
---
I
L
L
P
E
P
S
I
R
S
V
--
M
Q
K
Y
L
E
-
D
R
G
E
V
T
F
E
K
I
-
F
-
S
-
Q
K
L
G
Y
L
L
F
R
D
F
C
L
K
H
L
E
E
A
K
P
L
----
V
E
----
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
L
V
C
S
R
E
I
F
D
T
Y
I
M
K
E
L
-
L
A
C
S
H
P
F
S
K
S
A
I
E
H
V
Q
G
H
L
V
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
---
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
-
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
----
S
Q
----
H
--
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
----
C
-
D
--
F
--
S
---
K
-
K
--
K
--
P
-
H
-
A
S
---
V
--
G
T
H
-----
G
Y
M
A
P
E
-
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
-
D
K
-
H
-
E
I
D
------
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
-
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
------------------
D
T
-
K
-
G
----------
I
K
---
L
L
D
------
S
D
Q
E
L
Y
R
N
F
-
P
-
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
T
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
N
P
F
L
T
Q
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
-
E
--
E
-
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
V
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
---------------------
5
PsiBlast_PDB
93.97
84%
-106
- C1 -
-
5WG4
8.7
-
ARBK1_HUMAN
A:
[31-668]
--------------------------------------
K
---
I
L
L
P
E
P
S
I
R
S
V
--
M
Q
K
Y
L
E
-
D
R
G
E
V
T
F
E
K
I
-
F
-
S
-
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
H
L
E
E
A
R
P
L
----
V
E
----
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
-
L
A
C
S
H
P
F
S
K
S
A
T
E
H
V
Q
G
H
L
G
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
---
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
-
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
----
S
Q
----
H
--
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
----
C
-
D
--
F
--
S
---
K
-
K
--
K
--
P
-
H
-
A
S
---
V
--
G
T
H
-----
G
Y
M
A
P
E
-
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
-
D
K
-
H
-
E
I
D
------
R
M
T
L
T
--
V
E
L
P
D
S
F
S
P
E
L
R
-
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
E
V
N
A
A
D
A
------------
T
-
K
-
G
----------
I
K
---
L
L
D
------
S
D
Q
E
L
Y
R
N
F
-
P
-
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
N
K
Q
L
G
---
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
N
P
F
L
T
Q
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
--
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
-
E
--
E
-
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
I
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
--------------------
1
PsiBlast_PDB
93.84
84%
-104
- C1 -
-
3CIK
-
-
ARBK1_HUMAN
A:
[29-669]
---------------------------------
S
K
---
K
---
I
L
L
P
E
P
S
I
R
S
V
--
M
Q
K
Y
L
E
-
D
R
G
E
V
T
F
E
K
I
-
F
-
S
-
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
H
L
E
E
A
R
P
L
----
V
E
----
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
-
L
A
C
S
H
P
F
S
K
S
A
T
E
H
V
Q
G
H
L
G
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
---
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
-
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
----
S
Q
----
H
--
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
----
C
-
D
--
F
--
S
---
K
-
K
--
K
--
P
-
H
-
A
S
---
V
--
G
T
H
-----
G
Y
M
A
P
E
-
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
-
D
K
-
H
-
E
I
D
------
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
-
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
-------------------
T
-
K
-
G
----------
I
K
---
L
L
D
------
S
D
Q
E
L
Y
R
N
F
-
P
-
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
-----
T
Q
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
-
E
--
E
-
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
I
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
R
-------------------
548
HHSearch
93.76
83%
-89
- C1 -
-
4MK0
6.8
-
ARBK1_HUMAN
A:
[1-639]
----------------------------------
K
---
K
---
I
L
L
P
E
P
S
I
R
S
V
--
M
Q
K
Y
L
E
-
D
R
G
E
V
T
F
E
K
I
-
F
-
S
-
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
H
L
E
E
A
R
P
L
----
V
E
----
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
-
L
A
C
S
H
P
F
S
K
S
A
T
E
H
V
Q
G
H
L
G
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
---
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
-
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
----
S
Q
----
H
--
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
----
C
-
D
--
F
--
S
---
K
-
K
--
K
--
P
-
H
-
A
S
---
V
--
G
T
H
-----
G
Y
M
A
P
E
-
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
-
D
K
-
H
-
E
I
D
------
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
-
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
E
V
N
A
A
D
A
F
-----------
T
-
K
-
G
----------
I
K
---
L
L
D
------
S
D
Q
E
L
Y
R
N
F
-
P
-
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
N
P
F
L
T
Q
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
---
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V-
E
E
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
I
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
--------------------
4
PsiBlast_PDB
93.73
84%
-106
- C1 -
-
5WG3
8.4
-
ARBK1_HUMAN
A:
[30-668]
----------------------------------
K
---
K
---
I
L
L
P
E
P
S
I
R
S
V
--
M
Q
K
Y
L
E
-
D
R
G
E
V
T
F
E
K
I
-
F
-
S
-
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
H
L
E
E
A
R
P
L
----
V
E
----
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
-
L
A
C
S
H
P
F
S
K
S
A
T
E
H
V
Q
G
H
L
G
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
---
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
-
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
----
S
Q
----
H
--
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
----
C
-
D
--
F
--
S
---
K
-
K
--
K
--
P
-
H
-
A
S
---
V
--
G
T
H
-----
G
Y
M
A
P
E
-
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
---
T
K
-
D
K
-
H
-
E
I
D
------
R
M
T
L
T
--
V
E
L
P
D
S
F
S
P
E
L
R
-
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
E
V
N
A
A
D
A
--------
E
--
D
T
-
K
-
G
----------
I
K
---
L
L
D
------
S
D
Q
E
L
Y
R
N
F
-
P
-
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
N
------
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
N
P
F
L
T
Q
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
--
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
-
E
--
E
-
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
I
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
--------------------
20
PsiBlast_PDB
93.64
84%
-106
- C1 -
-
5UKK
8.4
-
ARBK1_HUMAN
A:
[1-638]
----------------------------------
K
---
K
---
I
L
L
P
E
P
S
I
R
S
V
--
M
Q
K
Y
L
E
-
D
R
G
E
V
T
F
E
K
I
-
F
-
S
-
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
H
L
E
E
A
R
P
L
----
V
E
----
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
----------
F
S
K
S
A
T
E
H
V
Q
G
H
L
G
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
---
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
-
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
----
S
Q
----
H
--
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
----
C
-
D
--
F
--
S
---
K
-
K
--
K
--
P
-
H
-
A
S
---
V
--
G
T
H
-----
G
Y
M
A
P
E
-
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
-
D
K
-
H
-
E
I
D
------
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
-
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
E
V
N
A
A
D
A
F
---------------------------------
D
------
S
D
Q
E
L
Y
R
N
F
-
P
-
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
G
N
P
F
L
T
Q
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
V
-
E
--
E
-
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
I
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
---------------------
26
Blastp_CBE
77.96
85%
-128
- C1 -
-
5UVC
7.2
-
ARBK1_HUMAN
A:
[39-545]
----------------------------------
K
---
K
---
I
L
L
P
E
P
S
I
R
S
V
--
M
Q
K
Y
L
E
-
D
R
G
E
V
T
F
E
K
I
-
F
-
S
-
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
H
L
E
E
A
R
P
L
----
V
E
----
F
Y
E
E
I
K
K
Y
E
K
L
E
-----
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
-
L
A
----------------------
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
---
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
-
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
----
S
Q
----
H
--
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
----
C
-
D
--
F
--
S
---
K
-
K
--
K
--
P
-
H
-
A
S
---
V
--
G
T
H
-----
G
Y
M
A
P
E
-
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
-
D
K
-
H
-
E
I
D
------
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
-
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
----------------------------------------
L
D
------
S
D
Q
E
L
Y
R
N
F
-
P
-
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------
556
HHSearch
77.78
84%
-128
- C1 -
-
5UVC
7.2
-
ARBK1_HUMAN
A:
[39-545]
----------------------------------
K
---
K
---
I
L
L
P
E
P
S
I
R
S
V
--
M
Q
K
Y
L
E
-
D
R
G
E
V
T
F
E
K
I
-
F
-
S
-
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
H
L
E
E
A
R
P
L
----
V
E
----
F
Y
E
E
I
K
K
Y
E
K
L
E
-----
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
-
L
A
----------------------
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
---
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
-
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
----
S
Q
----
H
--
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
----
C
-
D
--
F
--
S
---
K
-
K
--
K
--
P
-
H
-
A
S
---
V
--
G
T
H
-----
G
Y
M
A
P
E
-
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
-
D
K
-
H
-
E
I
D
------
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
-
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
----------------------------------------
L
D
------
S
D
Q
E
L
Y
R
N
F
-
P
-
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------
547
HHSearch
77.56
80%
23
- C1 -
-
3V5W
6.8
-
ARBK1_HUMAN
A:
[30-668]
--------------------------------
K
K
I
---
L
---
L
P
E
P
S
I
R
S
V
M
Q
KY
L
E
D
R
G
-----
E
V
T
F
E
K
I
-
F
-
S
-
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
H
L
E
E
A
R
P
L
----
V
E
----
F
Y
E
E
I
K
K
Y
E
K
L
E
T
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
-
L
A
C
S
H
P
F
S
K
S
A
T
E
H
V
Q
G
H
L
G
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
---
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
-
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
----
S
Q
----
H
--
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
----
C
-
D
--
F
--
S
---
K
-
K
--
K
--
P
-
H
-
A
S
---
V
--
G
T
H
-----
G
Y
M
A
P
E
-
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
-
D
K
-
H
-
E
I
D
------
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
-
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
E
V
N
A
A
D
A
F
D
------------
K
-
G
----------
I
K
---
L
L
D
------
S
D
Q
E
L
Y
R
N
F
-
P
-
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
R
K
K
A
K
N
K
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
M
H
G
Y
M
S
K
M
-------
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
W
R
G
E
---
G
E
A
P
Q
S
L
L
T
M
E
E
I
Q
S
VE
E
-
T
Q
I
K
E
R
K
C
L
L
L
K
I
R
G
G
K
Q
F
I
L
Q
C
D
S
D
P
E
L
V
Q
W
K
K
E
L
R
D
A
Y
R
E
A
Q
Q
L
V
Q
R
V
P
K
M
K
N
K
P
--------------------
27
Blastp_CBE
70.62
85%
-115
- C1 -
-
5UUU
9.7
-
ARBK1_HUMAN
A:
[40-547]
--------------------------------------
K
---
I
L
L
P
E
P
S
I
R
S
V
--
M
Q
K
Y
L
E
-
D
R
G
E
V
T
F
E
K
I
-
F
-
S
-
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
------------------------------------------------------------------------------------------
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
---
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
-
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
----
S
Q
----
H
--
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
----
C
-
D
--
F
--
S
---
K
-
K
--
K
--
P
-
H
-
A
S
---
V
--
G
T
H
-----
G
Y
M
A
P
E
-
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
-
D
K
-
H
-
E
I
D
------
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
-
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
E
V
-------------
E
--
D
T
-
K
-
G
----------
I
K
---
L
L
D
------
S
D
Q
E
L
Y
R
N
F
-
P
-
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------
554
HHSearch
70.43
84%
-115
- C1 -
-
5UUU
9.7
-
ARBK1_HUMAN
A:
[40-546]
--------------------------------------
K
---
I
L
L
P
E
P
S
I
R
S
V
--
M
Q
K
Y
L
E
-
D
R
G
E
V
T
F
E
K
I
-
F
-
S
-
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
------------------------------------------------------------------------------------------
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
---
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
-
E
R
I
M
L
S
L
V
S
T
G
D
C
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
----
S
Q
----
H
--
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
----
C
-
D
--
F
--
S
---
K
-
K
--
K
--
P
-
H
-
A
S
---
V
--
G
T
H
-----
G
Y
M
A
P
E
-
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
-
D
K
-
H
-
E
I
D
------
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
-
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
-
R
G
A
Q
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
E
V
-------------
E
--
D
T
-
K
-
G
----------
I
K
---
L
L
D
------
S
D
Q
E
L
Y
R
N
F
-
P
-
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
D
R
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------
567
Fugue
58.52
38%
-42
- C1 -
-
2ACX
4.8
-
GRK6_HUMAN
A:
[14-532]
------------------
K
A
R
K
G
--
K
S
K
---
K
W
R
Q
---
M
---
L
Q
F
P
H
I
S
Q
C
E
E
--
L
R
L
S
L
E
-
R
D
Y
H
S
L
C
E
R
------
N
P
I
G
R
L
L
F
R
E
F
C
A
T
R
-
P
E
L
S
R
C
----
V
A
----
F
L
D
G
V
A
E
Y
E
-
V
T
P
D
D
K
R
K
A
C
G
R
N
L
T
Q
N
F
L
S
H
T
G
-
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
-
K
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
---
A
T
G
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
K
G
E
A
M
A
L
N
-
E
K
Q
I
L
E
K
V
N
S
---
R
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
---
F
H
I
----
Y
H
----
M
--
G
QA
G
--
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
---
A
----
V
-
H
--
V
--
P
---
E
-
G
--
Q
--
T
-
I
K
G
R
---
V
--
G
T
V
-----
G
Y
M
A
P
E
-
V
V
-
K
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
Q
R
K
K
K
I
K
R
-
E
-
E
V
E
------
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
-
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
-
R
G
-
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
E
------------------------------------
P
------
T
D
Q
D
F
Y
Q
K
F
-
A
T
G
-
S
V
P
I
P
W
Q
N
E
M
V
E
T
---------------------------------------------------------------------------------------------------------------------------------
E
C
F
Q
E
L
N
--------------------------
V
F
G
L
D
G
S
557
HHSearch
56.37
35%
-25
- C1 -
-
4L9I
4.8
-
GRK1_BOVIN
A:
[5-501]
-------------------------------
K
Y
L
A
---
R
---
L
K
L
P
P
L
S
K
C
E
A
--
L
R
E
S
L
-----
D
L
G
F
E
G
M
-
C
L
E
-
Q
P
I
G
K
R
L
F
Q
Q
F
L
R
T
-
H
E
Q
H
G
P
A
----
L
Q
----
L
W
K
D
I
E
D
Y
D
T
A
D
D
A
-
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
-
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
----
A
-
R
A
G
A
G
D
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
---
A
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
Q
G
A
M
V
-
E
K
K
I
L
A
K
V
---
H
S
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
---
Y
H
I
----
Y
N
VDED
N
--
P
--
G
--
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
---
A
----
V
-
E
--
L
--
K
---
A
-
G
QT
K
--
T
-
K
-
G
Y
---
A
--
G
T
P
-----
G
F
M
A
P
E
-
L
L
L
G
-
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
-
V
E
N
K
-
E
L
K
------
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
-
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
I
Q
D
V
G
A
F
S
T
----
V
-
K
-
G
----------
V
A
---
F
E
K
------
A
D
T
E
F
F
Q
E
F
A
S
-
G
-
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
558
HHSearch
55.10
38%
6
- C1 -
-
3NYO
4.4
-
GRK6_HUMAN
B:
[2-531]
--
E
L
E
N
I
V
A
N
T
V
L
L
K
A
R
E
G
G
G
G
N
--
R
K
G
KSK
K
W
R
Q
---
M
---
L
Q
F
P
H
I
S
Q
C
E
E
--
L
R
L
S
L
-----
E
R
D
Y
H
S
L
-
C
-
E
R
Q
P
I
G
R
L
L
F
R
E
F
C
A
T
R
-
P
E
L
S
R
C
----
V
A
----
F
L
D
G
V
A
E
Y
E
V
T
P
D
D
-
K
R
K
A
C
G
R
Q
L
T
Q
N
F
L
S
H
T
G
-
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
-
Q
G
P
C
K
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
P
-
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
---
A
T
G
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
K
G
E
A
M
A
L
N
-
E
K
Q
I
L
E
K
V
---
N
S
R
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
---
F
H
I
----
Y
H
----
M
GQ
A
--
G
--
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
---
A
----
V
-
H
--
V
--
P
---
E
-
G
Q-
T
--
I
-
K
-
G
R
---
V
--
G
T
V
-----
G
Y
M
A
P
E
-
V
V
K
N
E
-
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
---
K
K
-
I
K
-
R
E
E
V
E
------
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
-
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
-
R
G
-
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
K
D
V
L
D
I
E
Q
F
S
T
V
-----
K
-
G
----------
V
E
---
L
E
P
------
T
D
Q
D
F
Y
Q
K
F
-
A
-
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
------------------------------------------------------------------------------------------------------------------------------------------------------------
568
Fugue
54.01
34%
-10
- C1 -
-
3C4Z
5.4
-
GRK1_BOVIN
A:
[31-533]
-------------------------
R
D
R
---
K
Y
L
A
---
R
---
L
K
L
P
P
----
L
S
--
K
C
E
A
L
R
-
E
S
L
D
L
G
F
E
G
M
-
C
L
E
-
Q
P
I
G
K
R
L
F
Q
Q
F
L
R
T
H
-
E
Q
H
G
P
A
----
L
Q
----
L
W
K
D
I
E
D
Y
D
T
A
D
-
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
---------
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
---
A
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
Q
G
A
M
V
-
E
K
K
I
L
A
K
V
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
---
Y
H
I
YNVD
E
D
----
N
--
P
--
G
--
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
---
A
----
V
-
E
--
L
--
K
AG-
Q
-
T
--
K
--
T
-
K
-
G
Y
---
A
--
G
T
P
-----
G
F
M
A
P
E
-
L
L
-
L
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
-
K
-
E
L
K
------
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
-
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
---------
G
--
A
F
-
S
-
G
----------
V
A
---
F
E
K
------
A
D
T
E
F
F
Q
E
F
-
A
-
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------
552
HHSearch
53.31
34%
-16
- C1 -
-
3C4Z
5.4
-
GRK1_BOVIN
A:
[31-533]
-------------------------
R
D
R
---
K
Y
L
A
---
R
---
L
K
L
P
P
L
S
K
C
E
A
--
L
R
E
S
L
-----
D
L
G
F
E
G
M
C
L
-
E
-
Q
P
I
G
K
R
L
F
Q
Q
F
L
R
T
H
-
E
Q
H
G
P
A
----
L
Q
----
L
W
K
D
I
E
D
Y
D
T
A
D
D
A
L
-
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
-
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
-----
A
R
A
G
---
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
P
-
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
---
A
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
Q
G
A
M
V
-
E
K
K
I
L
A
K
V
---
H
S
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
---
Y
H
I
----
Y
N
VDED
N
--
P
--
G
--
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
---
A
----
V
-
E
--
L
--
K
---
A
-
G
--
Q
TK
T
-
K
-
G
Y
---
A
--
G
T
P
-----
G
F
M
A
P
E
-
L
L
L
G
-
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
-
V
E
N
K
-
E
L
K
------
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
-
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
----
G
A
F
S
---------
G
----------
V
A
---
F
E
K
------
A
D
T
E
F
F
Q
E
F
A
S
-
G
-
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------
550
HHSearch
52.71
36%
22
- C1 -
-
4YHJ
5.9
-
GRK4_HUMAN
A:
[25-525]
---------------------------
G
RSK
K
W
K
E
---
I
---
L
T
L
P
P
V
S
Q
C
S
E
--
L
R
H
S
I
E
-
K
D
Y
S
S
L
C
D
K
------
Q
P
I
G
R
R
L
F
R
Q
F
C
D
T
-
K
P
T
L
K
R
H
----
I
E
----
F
L
D
A
V
A
E
Y
E
V
A
D
-
D
E
D
R
S
D
C
G
L
S
I
L
D
R
F
F
N
D
K
L
-
A
A
P
L
P
E
I
P
P
D
V
V
T
E
C
R
L
G
L
K
E
E
N
P
S
K
K
A
F
E
E
C
T
R
V
A
H
N
Y
L
R
G
E
P
F
E
E
Y
Q
E
S
S
Y
F
S
Q
F
L
Q
W
K
W
L
E
R
Q
P
-
V
T
K
N
T
F
R
H
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
---
A
T
G
K
M
Y
A
C
K
K
L
Q
K
K
R
I
-
K
K
R
K
G
E
A
M
A
L
N
-
E
K
R
I
L
E
K
V
---
Q
S
R
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
---
F
H
I
----
Y
N
----
L
GN
P
--
G
--
F
D
E
Q
R
A
V
F
Y
A
A
E
L
C
C
G
L
E
D
L
Q
R
-
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
R
G
H
I
R
I
S
D
L
G
L
---
A
----
T
-
E
--
I
--
P
---
E
-
G
Q-
R
--
V
-
R
-
G
R
---
V
--
G
T
V
-----
G
Y
M
A
P
E
-
V
V
N
N
-
E
K
Y
T
F
S
P
D
W
W
G
L
G
C
L
I
Y
E
M
I
Q
G
H
S
P
F
K
K
Y
K
E
K
-
V
K
-
W
E
E
V
D
------
Q
R
I
K
N
D
T
E
E
Y
S
E
K
F
S
E
D
A
K
-
S
I
C
R
M
L
L
T
K
N
P
S
K
R
L
G
C
-
R
G
-
E
G
A
A
G
V
K
Q
H
P
V
F
K
D
I
N
F
R
R
L
E
A
N
M
L
E
P
P
F
C
P
D
P
H
A
V
Y
C
K
D
V
L
D
I
E
Q
F
S
V
----
V
-
K
-
G
----------
I
Y
---
L
D
T
------
A
D
E
D
F
Y
A
R
F
-
A
-
T
G
C
V
S
I
P
W
Q
N
E
M
I
E
S
G
C
F
K
D
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
555
HHSearch
52.65
37%
11
- C1 -
-
4TND
4.6
-
GRK5_HUMAN
A:
[15-526]
---------------
A
R
E
G
G
G
G
K
--
R
K
G
KSK
K
W
K
E
---
I
---
L
K
F
P
H
I
S
Q
C
E
D
--
L
R
R
T
I
-----
D
R
D
Y
C
S
L
-
C
-
D
K
Q
P
I
G
R
L
L
F
R
Q
F
C
E
T
R
-
P
G
L
E
C
Y
----
I
Q
----
F
L
D
S
V
A
E
Y
E
V
T
P
D
E
K
L
G
-
E
K
G
K
K
I
M
T
K
Y
L
T
P
K
S
-
P
V
F
I
A
Q
V
G
Q
D
L
V
S
Q
T
E
E
K
L
L
Q
-
K
P
C
K
E
L
F
S
A
C
A
Q
S
V
H
E
Y
L
R
G
E
P
F
H
E
Y
L
D
S
M
F
F
D
R
F
L
Q
W
K
W
L
E
R
Q
P
-
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
---
A
T
G
K
M
Y
A
C
K
R
L
E
K
K
R
I
-
K
K
R
K
G
E
S
M
A
L
N
-
E
K
Q
I
L
E
K
V
---
N
S
Q
F
V
V
N
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
---
F
H
I
----
Y
N
----
M
GN
P
--
G
--
F
E
E
E
R
A
L
F
Y
A
A
E
I
L
C
G
L
E
D
L
H
H
-
E
N
T
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
Y
G
H
I
R
I
S
D
L
G
L
---
A
----
V
-
K
--
I
--
P
---
E
-
G
--
D
L-
I
-
R
-
G
R
---
V
--
G
T
V
-----
G
Y
M
A
P
E
-
V
L
N
N
-
Q
R
Y
G
L
S
P
D
Y
W
G
L
G
C
L
I
Y
E
M
I
E
G
Q
S
P
F
R
G
R
K
E
K
-
V
K
R
E
-
E
V
D
------
R
R
V
L
E
T
E
E
V
Y
S
H
K
F
S
E
E
A
K
-
S
I
C
K
M
L
L
T
K
D
A
K
Q
R
L
G
C
-
Q
E
-
E
E
A
A
E
V
K
R
H
P
F
F
R
N
M
N
F
K
R
L
E
A
G
M
L
D
P
P
F
V
P
D
P
R
A
V
Y
C
K
D
V
L
D
I
E
Q
F
S
T
----
V
-
K
-
G
----------
V
N
---
L
D
H
------
T
D
D
D
F
Y
S
K
F
-
S
-
T
G
S
V
S
I
P
W
Q
N
E
M
I
E
T
E
C
F
K
E
L
N
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
30
Blastp_CBE
51.95
39%
35
- C1 -
-
3NYN
4.0
-
GRK6_HUMAN
B:
[2-518]
--
E
L
E
N
I
V
A
N
T
V
L
L
K
A
R
E
G
G
G
G
N
--
R
K
G
---
K
S
K
K
W--
R
---
Q
M
L
Q
F
P
H
I
S
Q
C
--
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
----
R
-
Q
P
I
G
R
L
L
F
R
E
F
C
A
T
R
-
P
E
L
S
R
C
----
V
A
----
F
L
D
G
V
A
E
Y
E
V
T
P
D
D
K
R
K
A
C
-
G
R
Q
L
T
Q
N
F
L
S
H
T
G
-
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
K
D
-
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
---
A
T
G
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
K
G
E
A
M
A
L
N
-
E
K
Q
I
L
E
K
V
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
FHI
Y
H
M
----
G
Q
----
A
--
G
-----
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
---
A
----
V
-
H
--
V
--
P
---
E
-
G
--
Q
--
T
I
K
-
G
R
---
V
--
G
T
V
-----
G
Y
M
A
P
E
-
V
V
-
K
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
---
K
K
-
I
K
-
R
E
E
V
E
------
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
-
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
-
R
G
-
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
K
D
V
L
D
I
E
Q
F
S
----
T
V
-
K
-
G
----------
V
E
---
L
E
P
------
T
D
Q
D
F
Y
Q
K
F
-
A
-
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
Blastp_CBE
51.70
37%
35
- C1 -
-
4YHJ
5.9
-
GRK4_HUMAN
A:
[25-519]
---------------------------
G
---
R
S
K
K
---
W
KEI
L
T
L
P
P
V
S
Q
C
S
E
--
L
R
H
S
I
E
-
K
D
Y
S
S
L
C
D
K
------
Q
P
I
G
R
R
L
F
R
Q
F
C
-----
D
T
K
P
T
----
L
K
RHIE
F
L
D
A
V
A
E
Y
E
V
A
D
D
E
D
R
S
D
C
-
G
L
S
I
L
D
R
F
F
N
D
K
L
-
A
A
P
L
P
E
I
P
P
D
V
V
T
E
C
R
L
G
L
K
E
E
N
P
S
K
K
A
F
E
E
C
T
R
V
A
H
N
Y
L
R
G
E
P
F
E
E
Y
Q
E
S
S
Y
F
S
Q
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
H
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
---
A
T
G
K
M
Y
A
C
K
K
L
Q
K
K
R
I
-
K
K
R
K
G
E
A
M
A
L
N
-
E
K
R
I
L
E
K
V
Q
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
---
F
H
I
----
Y
N
----
L
--
G
NP
G
--
F
D
E
Q
R
A
V
F
Y
A
A
E
L
C
C
G
L
E
D
L
Q
R
-
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
R
G
H
I
R
I
S
D
L
G
L
---
A
----
T
-
E
--
I
--
P
---
E
G
Q
--
R
--
V
-
R
-
G
R
---
V
--
G
T
V
-----
G
Y
M
A
P
E
-
V
V
N
-
N
E
K
Y
T
F
S
P
D
W
W
G
L
G
C
L
I
Y
E
M
I
Q
G
H
S
P
F
K
K
Y
K
E
K
-
V
K
W
E
-
E
V
D
------
Q
R
I
K
N
D
T
E
E
Y
S
E
K
F
S
E
D
A
K
-
S
I
C
R
M
L
L
T
K
N
P
S
K
R
L
G
C
-
R
G
-
E
G
A
A
G
V
K
Q
H
P
V
F
K
D
I
N
F
R
R
L
E
A
N
M
L
E
P
P
F
C
P
D
P
H
A
V
Y
C
K
D
V
L
D
I
E
Q
F
S
V
----
V
-
K
-
G
----------
I
Y
---
L
D
T
------
A
D
E
D
F
Y
A
R
F
-
A
-
T
G
C
V
S
I
P
W
Q
N
E
M
I
E
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
551
HHSearch
51.38
36%
22
- C1 -
-
4YHJ
5.3
-
GRK4_HUMAN
B:
[25-527]
---------------------------
G
RSK
K
W
K
E
---
I
---
L
T
L
P
P
V
S
Q
C
S
E
--
L
R
H
S
I
E
-
K
D
Y
S
S
L
C
D
K
------
Q
P
I
G
R
R
L
F
R
Q
F
C
D
T
-
K
P
T
L
K
R
H
----
I
E
----
F
L
D
A
V
A
E
Y
E
V
A
D
-
D
E
D
R
S
D
C
G
L
S
I
L
D
R
F
F
N
D
K
L
-
A
A
P
L
P
E
I
P
P
D
V
V
T
E
C
R
L
G
L
K
E
E
N
P
S
K
K
A
F
E
E
C
T
R
V
A
H
N
Y
L
R
G
E
P
F
E
E
Y
Q
E
S
S
Y
F
S
Q
F
L
Q
W
K
W
L
E
R
Q
P
-
V
T
K
N
T
F
R
H
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
---
A
T
G
K
M
Y
A
C
K
K
L
Q
K
K
R
I
-
K
K
R
K
G
E
A
M
A
L
N
-
E
K
R
I
L
E
K
V
---
Q
S
R
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
---
F
H
I
----
Y
N
----
L
GN
P
--
G
--
F
D
E
Q
R
A
V
F
Y
A
A
E
L
C
C
G
L
E
D
L
Q
R
-
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
R
G
H
I
R
I
S
D
L
G
L
---
A
----
T
-
E
--
I
--
P
---
E
-
G
Q-
R
--
V
-
R
-
G
R
---
V
--
G
T
V
-----
G
Y
M
A
P
E
-
V
V
N
N
-
E
K
Y
T
F
S
P
D
W
W
G
L
G
C
L
I
Y
E
M
I
Q
G
H
S
P
F
K
K
Y
K
E
K
-
V
K
W
E
-
E
V
D
------
Q
R
I
K
N
D
T
E
E
Y
S
E
K
F
S
E
D
A
K
-
S
I
C
R
M
L
L
T
K
N
P
S
K
R
L
G
C
-
R
G
-
E
G
A
A
G
V
K
Q
H
P
V
F
K
D
I
N
F
R
R
L
E
A
N
M
L
E
P
P
F
C
P
D
P
H
A
V
Y
C
-------------------
G
----------
I
Y
---
L
D
T
------
A
D
E
D
F
Y
A
R
F
-
A
-
T
G
C
V
S
I
P
W
Q
N
E
M
I
E
S
G
C
F
K
D
I
N
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
35
Blastp_CBE
51.06
39%
9
- C1 -
-
4TND
4.7
-
GRK5_HUMAN
A:
[60-518]
-----------------------------------------------------------------------------
Q
P
I
G
R
L
L
F
R
Q
F
C
-----
E
T
R
P
G
LECY
I
Q
----
F
L
D
S
V
A
E
Y
E
-
V
T
P
D
E
K
L
G
E
K
G
K
K
I
M
T
K
Y
L
T
P
K
S
-
P
V
F
I
A
Q
V
G
Q
D
L
V
S
Q
T
E
E
K
L
L
Q
K
P
C
K
E
-
L
F
S
A
C
A
Q
S
V
H
E
Y
L
R
G
E
P
F
H
E
Y
L
D
S
M
F
F
D
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
---
A
T
G
K
M
Y
A
C
K
R
L
E
K
K
R
I
-
K
K
R
K
G
E
S
M
A
L
N
-
E
K
Q
I
L
E
K
V
N
S
Q
---
F
V
V
N
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
---
F
H
I
----
Y
N
----
M
--
G
--
N
PG
F
E
E
E
R
A
L
F
Y
A
A
E
I
L
C
G
L
E
D
L
H
H
-
E
N
T
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
Y
G
H
I
R
I
S
D
L
G
L
---
A
----
V
-
K
--
I
--
P
---
E
-
G
--
D
L-
I
-
R
-
G
R
---
V
--
G
T
V
-----
G
Y
M
A
P
E
-
V
L
N
-
N
Q
R
Y
G
L
S
P
D
Y
W
G
L
G
C
L
I
Y
E
M
I
E
G
Q
S
P
F
R
G
R
K
E
K
-
V
K
-
R
E
E
V
D
------
R
R
V
L
E
T
E
E
V
Y
S
H
K
F
S
E
E
A
K
-
S
I
C
K
M
L
L
T
K
D
A
K
Q
R
L
G
C
-
Q
E
-
E
E
A
A
E
V
K
R
H
P
F
F
R
N
M
N
F
K
R
L
E
A
G
M
L
D
P
P
F
V
P
D
P
R
A
V
Y
C
K
D
V
L
D
I
E
Q
F
S
----
T
V
-
K
-
G
----------
V
N
---
L
D
H
------
T
D
D
D
F
Y
S
K
F
-
S
-
T
G
S
V
S
I
P
W
Q
N
E
M
I
E
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Blastp_CBE
51.03
39%
34
- C1 -
-
3NYN
3.9
-
GRK6_HUMAN
A:
[2-518]
--
E
L
E
N
I
V
A
N
T
V
L
L
K
A
R
E
G
G
G
G
N
--
R
K
G
---
K
S
K
K
W--
R
---
Q
M
L
Q
F
P
H
I
S
Q
C
--
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
----
R
-
Q
P
I
G
R
L
L
F
R
E
F
C
A
T
R
-
P
E
L
S
R
C
----
V
A
----
F
L
D
G
V
A
E
Y
E
V
T
P
D
D
K
R
K
A
C
-
G
R
Q
L
T
Q
N
F
L
S
H
T
G
-
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
K
D
-
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
---
A
T
G
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
K
G
E
A
M
A
L
N
-
E
K
Q
I
L
E
K
V
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
FHI
Y
H
M
----
G
Q
----
A
--
G
-----
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
---
A
----
V
-
H
--
V
--
P
---
E
-
G
--
Q
--
T
I
K
-
G
R
---
V
--
G
T
V
-----
G
Y
M
A
P
E
-
V
V
-
K
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
---
K
K
-
I
K
-
R
E
E
V
E
------
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
-
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
-
R
G
-
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
K
D
V
L
D
I
E
Q
F
S
----
T
V
-
K
-
G
----------
V
E
---
L
E
P
------
T
D
Q
D
F
Y
Q
K
F
-
A
-
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Blastp_CBE
51.02
34%
19
- C1 -
-
3C4X
5.2
-
GRK1_BOVIN
A:
[30-522]
---------------------------
S
---
R
D
R
K
YLA
R
---
L
K
L
P
P
L
S
K
C
E
A
--
L
R
E
S
L
-----
D
L
G
F
E
G
M
C
L
-
E
-
Q
P
I
G
K
R
L
F
Q
Q
F
-
L
R
T
H
E
Q
H
G
P
A
----
L
Q
----
L
W
K
D
I
E
D
Y
D
T
A
D
D
A
L
-
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
-
L
D
A
E
T
V
A
R
-----
A
R
A
G
A
G
D
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
---
A
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
Q
G
A
M
V
-
E
K
K
I
L
A
K
V
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
---
Y
H
I
YNVD
E
D
----
N
--
P
--
G
--
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
---
A
----
V
-
E
--
L
KA
G
---
Q
-
T
--
K
--
T
-
K
-
G
Y
---
A
--
G
T
P
-----
G
F
M
A
P
E
-
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
-
K
-
E
L
K
------
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
-
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
--------
I
Q
D
V
G
A
F
S
T
----
V
-
K
-
G
----------
V
A
---
F
E
K
------
A
D
T
E
F
F
Q
E
F
-
A
-
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
Blastp_CBE
50.93
39%
10
- C1 -
-
4TNB
4.2
-
GRK5_HUMAN
A:
[60-518]
-----------------------------------------------------------------------------
Q
P
I
G
R
L
L
F
R
Q
F
C
-----
E
T
R
P
G
LECY
I
Q
----
F
L
D
S
V
A
E
Y
E
-
V
T
P
D
E
K
L
G
E
K
G
K
K
I
M
T
K
Y
L
T
P
K
S
-
P
V
F
I
A
Q
V
G
Q
D
L
V
S
Q
T
E
E
K
L
L
Q
K
P
C
K
E
-
L
F
S
A
C
A
Q
S
V
H
E
Y
L
R
G
E
P
F
H
E
Y
L
D
S
M
F
F
D
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
---
A
T
G
K
M
Y
A
C
K
R
L
E
K
K
R
I
-
K
K
R
K
G
E
S
M
A
L
N
-
E
K
Q
I
L
E
K
V
N
S
Q
---
F
V
V
N
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
---
F
H
I
----
Y
N
----
M
--
G
--
N
PG
F
E
E
E
R
A
L
F
Y
A
A
E
I
L
C
G
L
E
D
L
H
H
-
E
N
T
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
Y
G
H
I
R
I
S
D
L
G
L
---
A
----
V
-
K
--
I
--
P
---
E
-
G
--
D
L-
I
-
R
-
G
R
---
V
--
G
T
V
-----
G
Y
M
A
P
E
-
V
L
N
-
N
Q
R
Y
G
L
S
P
D
Y
W
G
L
G
C
L
I
Y
E
M
I
E
G
Q
S
P
F
R
G
R
K
E
K
-
V
K
-
R
E
E
V
D
------
R
R
V
L
E
T
E
E
V
Y
S
H
K
F
S
E
E
A
K
-
S
I
C
K
M
L
L
T
K
D
A
K
Q
R
L
G
C
-
Q
E
-
E
E
A
A
E
V
K
R
H
P
F
F
R
N
M
N
F
K
R
L
E
A
G
M
L
D
P
P
F
V
P
D
P
R
A
V
Y
C
K
D
V
L
D
I
E
Q
F
S
----
T
V
-
K
-
G
----------
V
N
---
L
D
H
------
T
D
D
D
F
Y
S
K
F
-
S
-
T
G
S
V
S
I
P
W
Q
N
E
M
I
E
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Blastp_CBE
50.82
39%
32
- C1 -
-
3NYO
4.4
-
GRK6_HUMAN
B:
[2-518]
--
E
L
E
N
I
V
A
N
T
V
L
L
K
A
R
E
G
G
G
G
N
--
R
K
G
---
K
S
K
K
W--
R
---
Q
M
L
Q
F
P
H
I
S
Q
C
--
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
----
R
-
Q
P
I
G
R
L
L
F
R
E
F
C
A
T
R
-
P
E
L
S
R
C
----
V
A
----
F
L
D
G
V
A
E
Y
E
V
T
P
D
D
K
R
K
A
C
-
G
R
Q
L
T
Q
N
F
L
S
H
T
G
-
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
K
D
-
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
---
A
T
G
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
K
G
E
A
M
A
L
N
-
E
K
Q
I
L
E
K
V
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
FHI
Y
H
M
----
G
Q
----
A
--
G
-----
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
---
A
----
V
-
H
--
V
--
P
---
E
-
G
--
Q
--
T
I
K
-
G
R
---
V
--
G
T
V
-----
G
Y
M
A
P
E
-
V
V
-
K
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
---
K
K
-
I
K
-
R
E
E
V
E
------
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
-
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
-
R
G
-
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
K
D
V
L
D
I
E
Q
F
S
----
T
V
-
K
-
G
----------
V
E
---
L
E
P
------
T
D
Q
D
F
Y
Q
K
F
-
A
-
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Blastp_CBE
50.80
34%
21
- C1 -
-
3C50
5.1
-
GRK1_BOVIN
A:
[30-522]
---------------------------
S
---
R
D
R
K
YLA
R
---
L
K
L
P
P
L
S
K
C
E
A
--
L
R
E
S
L
-----
D
L
G
F
E
G
M
C
L
-
E
-
Q
P
I
G
K
R
L
F
Q
Q
F
-
L
R
T
H
E
Q
H
G
P
A
----
L
Q
----
L
W
K
D
I
E
D
Y
D
T
A
D
D
A
L
-
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
-
L
D
A
E
T
V
A
R
-----
A
R
A
G
A
G
D
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
---
A
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
Q
G
A
M
V
-
E
K
K
I
L
A
K
V
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
---
Y
H
I
YNVD
E
D
----
N
--
P
--
G
--
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
---
A
----
V
-
E
--
L
KA
G
---
Q
-
T
--
K
--
T
-
K
-
G
Y
---
A
--
G
T
P
-----
G
F
M
A
P
E
-
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
-
K
-
E
L
K
------
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
-
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
I
Q
D
-----
T
----
V
-
K
-
G
----------
V
A
---
F
E
K
------
A
D
T
E
F
F
Q
E
F
-
A
-
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
Blastp_CBE
50.69
37%
32
- C1 -
-
4YHJ
5.3
-
GRK4_HUMAN
B:
[25-519]
---------------------------
G
---
R
S
K
K
---
W
KEI
L
T
L
P
P
V
S
Q
C
S
E
--
L
R
H
S
I
E
-
K
D
Y
S
S
L
C
D
K
------
Q
P
I
G
R
R
L
F
R
Q
F
C
-----
D
T
K
P
T
----
L
K
RHIE
F
L
D
A
V
A
E
Y
E
V
A
D
D
E
D
R
S
D
C
-
G
L
S
I
L
D
R
F
F
N
D
K
L
-
A
A
P
L
P
E
I
P
P
D
V
V
T
E
C
R
L
G
L
K
E
E
N
P
S
K
K
A
F
E
E
C
T
R
V
A
H
N
Y
L
R
G
E
P
F
E
E
Y
Q
E
S
S
Y
F
S
Q
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
H
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
---
A
T
G
K
M
Y
A
C
K
K
L
Q
K
K
R
I
-
K
K
R
K
G
E
A
M
A
L
N
-
E
K
R
I
L
E
K
V
Q
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
---
F
H
I
----
Y
N
----
L
--
G
NP
G
--
F
D
E
Q
R
A
V
F
Y
A
A
E
L
C
C
G
L
E
D
L
Q
R
-
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
R
G
H
I
R
I
S
D
L
G
L
---
A
----
T
-
E
--
I
--
P
---
E
G
Q
--
R
--
V
-
R
-
G
R
---
V
--
G
T
V
-----
G
Y
M
A
P
E
-
V
V
N
-
N
E
K
Y
T
F
S
P
D
W
W
G
L
G
C
L
I
Y
E
M
I
Q
G
H
S
P
F
K
K
Y
K
E
K
-
V
K
W
E
-
E
V
D
------
Q
R
I
K
N
D
T
E
E
Y
S
E
K
F
S
E
D
A
K
-
S
I
C
R
M
L
L
T
K
N
P
S
K
R
L
G
C
-
R
G
-
E
G
A
A
G
V
K
Q
H
P
V
F
K
D
I
N
F
R
R
L
E
A
N
M
L
E
P
P
F
C
P
D
P
H
A
V
Y
C
-------------------
G
----------
I
Y
---
L
D
T
------
A
D
E
D
F
Y
A
R
F
-
A
-
T
G
C
V
S
I
P
W
Q
N
E
M
I
E
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Blastp_CBE
50.46
34%
17
- C1 -
-
3C4Z
5.4
-
GRK1_BOVIN
A:
[31-522]
-------------------------------
R
D
R
K
YLA
R
---
L
K
L
P
P
L
S
K
C
E
A
--
L
R
E
S
L
-----
D
L
G
F
E
G
M
C
L
-
E
-
Q
P
I
G
K
R
L
F
Q
Q
F
-
L
R
T
H
E
Q
H
G
P
A
----
L
Q
----
L
W
K
D
I
E
D
Y
D
T
A
D
D
A
L
-
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
-
L
D
A
E
T
V
A
R
-----
A
R
A
G
---
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
---
A
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
Q
G
A
M
V
-
E
K
K
I
L
A
K
V
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
---
Y
H
I
YNVD
E
D
----
N
--
P
--
G
--
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
---
A
----
V
-
E
--
L
KA
G
---
Q
-
T
--
K
--
T
-
K
-
G
Y
---
A
--
G
T
P
-----
G
F
M
A
P
E
-
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
-
K
-
E
L
K
------
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
-
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
----
G
A
F
S
---------
G
----------
V
A
---
F
E
K
------
A
D
T
E
F
F
Q
E
F
-
A
-
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Blastp_CBE
50.39
39%
36
- C1 -
-
3NYO
4.5
-
GRK6_HUMAN
A:
[2-518]
--
E
L
E
N
I
V
A
N
T
V
L
L
K
A
R
E
G
G
G
G
N
--
R
K
G
---
K
S
K
K
W--
R
---
Q
M
L
Q
F
P
H
I
S
Q
C
--
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
----
R
-
Q
P
I
G
R
L
L
F
R
E
F
C
A
T
R
-
P
E
L
S
R
C
----
V
A
----
F
L
D
G
V
A
E
Y
E
V
T
P
D
D
K
R
K
A
C
-
G
R
Q
L
T
Q
N
F
L
S
H
T
G
-
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
K
D
-
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
---
A
T
G
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
K
G
E
A
M
A
L
N
-
E
K
Q
I
L
E
K
V
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
FHI
Y
H
M
----
G
Q
----
A
--
G
-----
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
---
A
----
V
-
H
--
V
--
P
---
E
-
G
--
Q
--
T
I
K
-
G
R
---
V
--
G
T
V
-----
G
Y
M
A
P
E
-
V
V
-
K
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
---
K
K
-
I
K
-
R
E
E
V
E
------
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
-
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
-
R
G
-
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
K
D
V
L
D
I
E
Q
F
S
----
T
V
-
K
-
G
----------
V
E
---
L
E
P
------
T
D
Q
D
F
Y
Q
K
F
-
A
-
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
Blastp_CBE
50.23
34%
21
- C1 -
-
3C4W
4.9
-
GRK1_BOVIN
A:
[31-522]
-------------------------------
R
D
R
K
YLA
R
---
L
K
L
P
P
L
S
K
C
E
A
--
L
R
E
S
L
-----
D
L
G
F
E
G
M
C
L
-
E
-
Q
P
I
G
K
R
L
F
Q
Q
F
-
L
R
T
H
E
Q
H
G
P
A
----
L
Q
----
L
W
K
D
I
E
D
Y
D
T
A
D
D
A
L
-
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
------
A
R
A
G
A
G
D
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
---
A
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
Q
G
A
M
V
-
E
K
K
I
L
A
K
V
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
---
Y
H
I
YNVD
E
D
----
N
--
P
--
G
--
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
---
A
----
V
-
E
--
L
KA
G
---
Q
-
T
--
K
--
T
-
K
-
G
Y
---
A
--
G
T
P
-----
G
F
M
A
P
E
-
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
-
K
-
E
L
K
------
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
-
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
---------
Q
D
V
G
A
F
S
T
----
V
-
K
-
G
----------
V
A
---
F
E
K
------
A
D
T
E
F
F
Q
E
F
-
A
-
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Blastp_CBE
49.93
34%
21
- C1 -
-
3C50
5.2
-
GRK1_BOVIN
B:
[30-522]
---------------------------
S
---
R
D
R
K
YLA
R
---
L
K
L
P
P
L
S
K
C
E
A
--
L
R
E
S
L
-----
D
L
G
F
E
G
M
C
L
-
E
-
Q
P
I
G
K
R
L
F
Q
Q
F
-
L
R
T
H
E
Q
H
G
P
A
----
L
Q
----
L
W
K
D
I
E
D
Y
D
T
A
D
D
A
L
-
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
-
L
D
A
E
T
V
A
R
-----
A
R
A
G
A
G
D
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
---
A
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
Q
G
A
M
V
-
E
K
K
I
L
A
K
V
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
---
Y
H
I
YNVD
E
D
----
N
--
P
--
G
--
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
---
A
----
V
-
E
--
L
KA
G
---
Q
-
T
--
K
--
T
-
K
-
G
Y
---
A
--
G
T
P
-----
G
F
M
A
P
E
-
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
-
K
-
E
L
K
------
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
-
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
--------
A
F
S
T
----
V
-
K
-
G
----------
V
A
---
F
E
K
------
A
D
T
E
F
F
Q
E
F
-
A
-
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Blastp_CBE
49.73
34%
19
- C1 -
-
3T8O
5.0
-
GRK1_BOVIN
A:
[30-522]
---------------------------
S
---
R
D
R
K
YLA
R
---
L
K
L
P
P
L
S
K
C
E
A
--
L
R
E
S
L
-----
D
L
G
F
E
G
M
C
L
-
E
-
Q
P
I
G
K
R
L
F
Q
Q
F
-
L
R
T
H
E
Q
H
G
P
A
----
L
Q
----
L
W
K
D
I
E
D
Y
D
T
A
D
D
A
L
-
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
-
L
D
A
E
T
V
A
R
-----
A
R
A
G
A
G
D
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
K
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
---
A
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
Q
G
A
M
V
-
E
K
K
I
L
A
K
V
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
---
Y
H
I
YNVD
E
D
----
N
--
P
--
G
--
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
---
A
----
V
-
E
--
L
KA
G
---
Q
-
T
--
K
--
T
-
K
-
G
Y
---
A
--
G
T
P
-----
G
F
M
A
P
E
-
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
-
K
-
E
L
K
------
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
-
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
-----
I
Q
D
V
G
A
F
---------------------
V
A
---
F
E
K
------
A
D
T
E
F
F
Q
E
F
-
A
-
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Blastp_CBE
49.58
34%
18
- C1 -
-
4PNI
7.9
-
GRK1_BOVIN
A:
[30-522]
---------------------------
S
---
R
D
R
K
YLA
R
---
L
K
L
P
P
L
S
K
C
E
A
--
L
R
E
S
L
-----
D
L
G
F
E
G
M
C
L
-
E
-
Q
P
I
G
K
R
L
F
Q
Q
F
-
L
R
T
H
E
Q
H
G
P
A
----
L
Q
----
L
W
K
D
I
E
D
Y
D
T
A
D
D
A
L
-
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
------
L
D
A
E
T
V
A
R
A
R
A
G
A
G
D
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
---
A
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
Q
G
A
M
V
-
E
K
K
I
L
A
K
V
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
---
Y
H
I
YNVD
E
D
----
N
--
P
--
G
--
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
---
A
----
V
-
E
--
L
KA
G
---
Q
-
T
--
K
--
T
-
K
-
G
Y
---
A
--
G
T
P
-----
G
F
M
A
P
E
-
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
-
K
-
E
L
K
------
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
-
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
I
----------------------------
A
---
F
E
K
------
A
D
T
E
F
F
Q
E
F
-
A
-
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
Blastp_CBE
49.42
35%
18
- C1 -
-
4L9I
5.4
-
GRK1_BOVIN
B:
[21-493]
-----------------------------------------------------------
L
R
-
E
S
L
D
L
G
F
E
G
M
C
L
-
E
-
Q
P
I
G
K
R
L
F
Q
Q
F
-
L
R
T
H
E
Q
H
G
P
A
----
L
Q
----
L
W
K
D
I
E
D
Y
D
T
A
D
D
A
L
-
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
------
A
R
A
G
A
G
D
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
---
A
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
Q
G
A
M
V
-
E
K
K
I
L
A
K
V
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
---
Y
H
I
YNVD
E
D
----
N
--
P
--
G
--
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
---
A
----
V
-
E
--
L
KA
G
---
Q
-
T
--
K
--
T
-
K
-
G
Y
---
A
--
G
T
P
-----
G
F
M
A
P
E
-
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
-
K
-
E
L
K
------
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
-
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
----------
T
----
V
-
K
-
G
----------
V
A
---
F
E
K
------
A
D
T
E
F
F
Q
E
F
-
A
-
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Blastp_CBE
49.39
39%
6
- C1 -
-
4WNK
8.5
-
GRK5_BOVIN
A:
[60-518]
-----------------------------------------------------------------------------
Q
P
V
G
R
L
L
F
R
Q
F
C
-----
E
T
R
P
G
LESY
I
Q
----
F
L
D
S
V
A
E
Y
E
-
V
T
P
D
E
K
L
G
E
K
G
K
E
I
M
T
K
Y
L
T
P
K
S
-
P
V
F
I
T
Q
V
G
R
D
L
V
S
Q
T
E
E
K
L
L
Q
K
P
C
K
E
-
L
F
S
A
C
V
Q
S
V
H
D
Y
L
R
G
E
P
F
H
E
Y
L
D
S
M
Y
F
D
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
---
A
T
G
K
M
Y
A
C
K
R
L
E
K
K
R
I
-
K
K
R
K
G
E
S
M
A
L
N
-
E
K
Q
I
L
E
K
V
N
S
R
---
F
V
V
N
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
---
F
H
I
----
Y
N
----
M
--
G
--
N
PG
F
E
E
E
R
A
L
F
Y
A
A
E
I
L
C
G
L
E
D
L
H
H
-
E
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
Y
G
H
I
R
I
S
D
L
G
L
---
A
----
V
-
K
--
I
--
P
---
E
-
G
--
D
L-
I
-
R
-
G
R
---
V
--
G
T
V
-----
G
Y
M
A
P
E
-
V
L
N
-
N
Q
R
Y
G
L
S
P
D
Y
W
G
L
G
C
L
I
Y
E
M
I
E
G
Q
S
P
F
R
G
R
K
E
K
-
V
K
-
R
E
E
V
D
------
R
R
V
L
E
T
E
E
V
Y
S
H
K
F
S
E
E
A
K
-
S
I
C
K
M
L
L
T
K
D
A
K
Q
R
L
G
C
-
Q
E
-
E
G
A
A
E
V
K
R
H
P
F
F
R
N
M
N
F
K
R
L
E
A
G
M
L
D
P
P
F
V
P
D
P
R
A
V
Y
--------------------------------------
H
------
T
D
D
D
F
Y
S
K
F
-
S
-
T
G
S
V
P
I
P
W
Q
S
E
M
I
E
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
Blastp_CBE
49.22
35%
20
- C1 -
-
4L9I
4.8
-
GRK1_BOVIN
A:
[21-493]
-----------------------------------------------------------
L
R
-
E
S
L
D
L
G
F
E
G
M
C
L
-
E
-
Q
P
I
G
K
R
L
F
Q
Q
F
-
L
R
T
H
E
Q
H
G
P
A
----
L
Q
----
L
W
K
D
I
E
D
Y
D
T
A
D
D
A
L
-
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
------
A
R
A
G
A
G
D
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
---
A
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
Q
G
A
M
V
-
E
K
K
I
L
A
K
V
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
---
Y
H
I
YNVD
E
D
----
N
--
P
--
G
--
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
---
A
----
V
-
E
--
L
KA
G
---
Q
-
T
--
K
--
T
-
K
-
G
Y
---
A
--
G
T
P
-----
G
F
M
A
P
E
-
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
-
K
-
E
L
K
------
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
-
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
I
Q
D
V
G
A
F
S
T
----
V
-
K
-
G
----------
V
A
---
F
E
K
------
A
D
T
E
F
F
Q
E
F
-
A
-
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Blastp_CBE
49.02
34%
18
- C1 -
-
3C4X
5.2
-
GRK1_BOVIN
B:
[31-522]
-------------------------------
R
D
R
K
YLA
R
---
L
K
L
P
P
L
S
K
C
E
A
--
L
R
E
S
L
-----
D
L
G
F
E
G
M
C
L
-
E
-
Q
P
I
G
K
R
L
F
Q
Q
F
-
L
R
T
H
E
Q
H
G
P
A
----
L
Q
----
L
W
K
D
I
E
D
Y
D
T
A
D
D
A
L
-
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
-
L
D
A
E
T
V
A
R
-----
A
--------
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
---
A
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
Q
G
A
M
V
-
E
K
K
I
L
A
K
V
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
---
Y
H
I
YNVD
E
D
----
N
--
P
--
G
--
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
---
A
----
V
-
E
--
L
KA
G
---
Q
-
T
--
K
--
T
-
K
-
G
Y
---
A
--
G
T
P
-----
G
F
M
A
P
E
-
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
-
K
-
E
L
K
------
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
-
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
---------------------------------------
E
K
------
A
D
T
E
F
F
Q
E
F
-
A
-
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Blastp_CBE
48.94
34%
18
- C1 -
-
3C51
4.1
-
GRK1_BOVIN
A:
[31-522]
-------------------------------
R
D
R
K
YLA
R
---
L
K
L
P
P
L
S
K
C
E
A
--
L
R
E
S
L
-----
D
L
G
F
E
G
M
C
L
-
E
-
Q
P
I
G
K
R
L
F
Q
Q
F
-
L
R
T
H
E
Q
H
G
P
A
----
L
Q
----
L
W
K
D
I
E
D
Y
D
T
A
D
D
A
L
-
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
-
L
D
A
E
T
V
A
R
-----
A
R
A
G
---
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
---
A
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
Q
G
A
M
V
-
E
K
K
I
L
A
K
V
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
---
Y
H
I
YNVD
E
D
----
N
--
P
--
G
--
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
---
A
----
V
-
E
--
L
KA
G
---
Q
-
T
--
K
--
T
-
K
-
G
Y
---
A
--
G
T
P
-----
G
F
M
A
P
E
-
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
-
K
-
E
L
K
------
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
-
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
-------------
S
T
----
V
-
K
-
G
----------
V
A
---
F
E
K
------
A
D
T
E
F
F
Q
E
F
-
A
-
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
566
HHSearch
47.72
33%
-127
- C1 -
-
4OTH
8.2
-
A:
[9-338]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
L
E
D
F
K
F
L
A
V
L
G
R
G
H
F
G
K
V
L
L
S
E
F
---
R
---
P
S
G
E
L
F
A
I
K
A
L
K
K
G
D
I
-
V
A
R
D
E
V
E
S
L
M
C
-
E
K
R
I
L
A
A
V
T
S
A
G
H
P
F
L
V
N
L
F
G
C
F
Q
T
P
E
H
V
C
F
V
M
E
Y
S
A
G
G
D
L
M
---
L
H
I
----
H
S
-------
D
--
V
--
F
S
E
P
R
A
I
F
Y
S
A
C
V
V
L
G
L
Q
F
L
H
E
-
H
K
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
T
E
G
Y
V
K
I
A
D
F
G
L
---
C
----
K
------------------------------------------------------
T
R
A
V
D
W
W
G
L
G
V
L
L
Y
E
M
L
V
G
E
S
P
F
P
G
D
D
E
E
-
E
-----
V
F
------
D
S
I
V
N
D
E
V
R
Y
P
R
F
L
S
A
E
A
I
-
G
I
M
R
R
L
L
R
R
N
P
E
R
R
L
G
S
-
S
E
-
R
D
A
E
D
V
K
K
Q
P
F
F
R
T
L
G
W
E
A
L
L
A
R
R
L
P
P
P
F
V
P
T
L
S
-----
G
R
T
D
V
S
N
F
D
E
E
--
F
T
-
G
-
E
APTLSPPRDA
R
P
---
L
T
A
------
A
E
Q
A
A
F
L
D
F
-
D
-
F
-
V
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
Blastp_CBE
47.67
34%
50
- C1 -
-
3C4W
5.0
-
GRK1_BOVIN
B:
[9-522]
------
V
V
A
N
S
A
F
I
A
A
R
G
S
F
D
A
S
SG
P
A
S
---
R
D
R
K
YLA
R
---
L
K
L
P
P
L
S
K
C
E
A
--
L
R
E
S
L
-----
D
L
G
F
E
G
M
C
L
-
E
-
Q
P
I
G
K
R
L
F
Q
Q
F
-
L
R
T
H
E
Q
H
G
P
A
----
L
Q
----
L
W
K
D
I
E
D
Y
D
T
A
D
D
A
L
-
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
------
A
R
--
A
G
D
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
---
A
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
Q
G
A
M
V
-
E
K
K
I
L
A
K
V
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
---
Y
H
I
YNVD
E
D
----
N
--
P
--
G
--
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
---
A
----
V
-
E
--
L
KA
G
---
Q
-
T
--
K
--
T
-
K
-
G
Y
---
A
--
G
T
P
-----
G
F
M
A
P
E
-
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
-
K
-
E
L
K
------
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
-
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
--------
T
----
V
-
K
-
G
----------
V
A
---
F
E
K
------
A
D
T
E
F
F
Q
E
F
-
A
-
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Blastp_CBE
47.30
34%
13
- C1 -
-
3C51
5.1
-
GRK1_BOVIN
B:
[31-522]
-------------------------------
R
D
R
K
YLA
R
---
L
K
L
P
P
L
S
K
C
E
A
--
L
R
E
S
L
-----
D
L
G
F
E
G
M
C
L
-
E
-
Q
P
I
G
K
R
L
F
Q
Q
F
-
L
R
T
H
E
Q
H
G
P
A
----
L
Q
----
L
W
K
D
I
E
D
Y
D
T
A
D
D
A
L
-
R
P
Q
K
A
Q
A
L
R
A
A
---
P
Q
A
Q
L
F
C
S
F
-
L
D
A
E
T
V
A
R
-----
A
R
A
----
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
---
A
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
Q
G
A
M
V
-
E
K
K
I
L
A
K
V
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
--
D
I
R
---
Y
H
I
Y-------------------
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
---
A
----
V
-
E
--
L
KA
G
---
Q
-
T
--
K
--
T
-
K
-
G
Y
---
A
--
G
T
P
-----
G
F
M
A
P
E
-
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
--
E
N
-
K
-
E
L
K
------
Q
R
V
-------
P
D
K
F
S
P
A
S
K
-
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
--------------------
K
-
G
----------
V
A
---
F
E
K
------
A
D
T
E
F
F
Q
E
F
-
A
-
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
Blastp_CBE
47.17
38%
42
- C1 -
-
2ACX
4.8
-
GRK6_HUMAN
A:
[14-518]
---------------------
G
N
--
R
K
G
---
K
S
K
K
W--
R
---
Q
M
L
Q
F
P
H
I
S
Q
C
--
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
----
R
-
N
P
I
G
R
L
L
F
R
E
F
C
A
T
R
-
P
E
L
S
R
C
----
V
A
----
F
L
D
G
V
A
E
Y
E
V
T
P
D
D
K
R
K
A
C
-
G
R
N
L
T
Q
N
F
L
S
H
T
G
-
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
K
D
-
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
---
A
T
G
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
K
G
E
A
M
A
L
N
-
E
K
Q
I
L
E
K
V
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
FHI
Y
H
M
----
G
Q
----
A
--
G
-----
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
---
A
----
V
-
H
--
V
--
P
---
E
-
G
--
Q
--
T
I
K
-
G
R
---
V
--
G
T
V
-----
G
Y
M
A
P
E
-
V
V
-
K
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
Q
R
K
K
K
-
I
K
-
R
E
E
V
E
------
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
-
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
-
R
G
-
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
------------------------------------
E
P
------
T
D
Q
D
F
Y
Q
K
F
-
A
-
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Blastp_CBE
45.30
38%
41
- C1 -
-
2ACX
4.8
-
GRK6_HUMAN
B:
[14-518]
---------------------
G
N
--
R
K
G
---
K
S
K
K
W--
R
---
Q
M
L
Q
F
P
H
I
S
Q
C
--
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
----
R
-
N
P
I
G
R
L
L
F
R
E
F
C
A
T
R
-
P
E
L
S
R
C
----
V
A
----
F
L
D
G
V
A
E
Y
E
V
T
P
D
D
K
R
K
A
C
-
G
R
N
L
T
Q
N
F
L
S
H
T
G
-
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
K
D
-
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
---
A
T
G
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
K
G
E
A
M
A
L
N
-
E
K
Q
I
L
E
K
V
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
FHI
Y
H
M
----------
A
--
G
-----
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
---
A
----
V
-
H
--
V
--
P
---
E
-
G
--
Q
--
T
I
K
-
G
R
---
V
--
G
T
V
-----
G
Y
M
A
P
E
-
V
V
-
K
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
Q
---
K
-
I
K
-
R
E
E
V
E
------
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
-
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
-
R
G
-
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
-------------------------------------
E
P
------
T
D
Q
D
F
Y
Q
K
F
-
A
-
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
417
Blastp_CBE
44.85
31%
-77
- C1 -
-
4DC2
5.9
-
KPCI_MOUSE
A:
[49-368]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
L
---
K
---
K
T
D
R
I
Y
A
M
R
V
V
K
K
E
L
V
-
N
----
I
D
W
V
Q
T
-
E
K
H
V
F
E
Q
A
S
--
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
---
F
H
M
----
Q
R
----
Q
--
R
--
K
--
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
---
C
----
K
-
E
--
G
--
L
---
R
-
P
--
G
--
D
-
T
-
T
S
---
T
FC
G
T
P
-----
N
Y
I
A
P
E
-
I
L
-
R
G
E
D
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
D
I
V
G
S
---------
N
TEDYLF
Q
V
I
L
E
K
Q
I
R
I
P
R
S
L
S
V
K
A
A
-
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
-
H
P
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
-----
N
I
S
G
E
F
G
L
D
N
F
D
S
Q
--
F
T
N
E
-
P
----------
V
Q
---
L
P
D
------
D
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
347
Blastp_CBE
44.59
34%
-66
- C1 -
-
4RA5
5.1
-
B:
[2-321]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
I
E
D
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
---
K
---
K
T
N
Q
F
F
A
I
K
A
L
K
K
D
V
V
-
L
M
D
D
D
V
E
C
T
M
V
-
E
K
R
V
L
S
L
--
A
W
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
---
Y
H
I
----
Q
S
----
C
--
H
--
K
--
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
---
C
----
K
-
E
NM
L
--
G
---
D
-
A
--
K
--
T
-
N
-
E
F
---
C
--
G
T
P
-----
D
Y
I
A
P
E
-
I
L
L
-
G
Q
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
H
---
G
Q
-
D
E
-
E
-
E
L
F
------
H
S
I
R
M
D
N
P
F
Y
P
R
W
L
E
K
E
A
K
-
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
-
R
G
-----
D
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
-----
K
V
K
S
P
F
D
--------------
P
----------
R
L
-----
D
RALINS
M
D
Q
N
M
F
R
N
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
349
Blastp_CBE
43.69
34%
-65
- C1 -
-
4Q9Z
5.9
-
B:
[2-331]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
I
E
D
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
---
K
---
K
T
N
Q
F
F
A
I
K
A
L
K
K
D
V
V
-
L
M
D
D
D
V
E
C
T
M
V
-
E
K
R
V
L
S
L
--
A
W
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
---
Y
H
I
----
Q
S
----
C
--
H
--
K
--
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
---
C
----
K
-
E
NM
L
--
G
---
D
-
A
--
K
--
T
-
N
-
E
F
---
C
--
G
T
P
-----
D
Y
I
A
P
E
-
I
L
L
-
G
Q
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
H
---
G
Q
-
D
E
-
E
-
E
L
F
------
H
S
I
R
M
D
N
P
F
Y
P
R
W
L
E
K
E
A
K
-
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
-
R
G
-----
D
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
-----
K
V
K
S
P
F
D
C
S
N
F
D
K
E
-------------------
L
---
F
A
D
RALINS
M
D
Q
N
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
350
Blastp_CBE
43.63
34%
-51
- C1 -
-
4Q9Z
4.5
-
KPCT_HUMAN
A:
[2-321]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
I
E
D
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
---
K
---
K
T
N
Q
F
F
A
I
K
A
L
K
K
D
V
V
-
L
M
D
D
D
V
E
C
T
M
V
-
E
K
R
V
L
S
L
--
A
W
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
---
Y
H
I
----
Q
S
----
C
--
H
--
K
--
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
---
C
----
K
-
E
NM
L
--
G
---
D
-
A
--
K
--
T
-
N
-
E
F
---
C
--
G
T
P
-----
D
Y
I
A
P
E
-
I
L
L
-
G
Q
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
H
---
G
Q
-
D
E
-
E
-
E
L
F
------
H
S
I
R
M
D
N
P
F
Y
P
R
W
L
E
K
E
A
K
-
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
-
R
G
-----
D
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
-----
K
V
K
S
P
F
D
C
S
N
F
D
K
E
FL
N
E
-
K
-
P
----------
R
L
---
F
A
D
RALINS
M
D
Q
N
M
F
R
N
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
326
Blastp_CBE
43.63
34%
-53
- C1 -
-
5F9E
7.4
-
KPCT_HUMAN
A:
[15-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
K
I
E
D
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
---
K
---
K
T
N
Q
F
F
A
I
K
A
L
K
K
D
V
V
-
L
M
D
D
D
V
E
C
T
M
V
-
E
K
R
V
L
S
L
--
A
W
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
---
Y
H
I
----
Q
S
----
C
--
H
--
K
--
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
---
C
----
K
-
E
NM
L
--
G
---
D
-
A
--
K
--
T
-
N
-
E
F
---
C
--
G
T
P
-----
D
Y
I
A
P
E
-
I
L
L
-
G
Q
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
H
---
G
Q
-
D
E
-
E
-
E
L
F
------
H
S
I
R
M
D
N
P
F
Y
P
R
W
L
E
K
E
A
K
-
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
-
R
G
-----
D
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
-----
K
V
K
S
P
F
D
C
S
N
F
D
K
E
FL
N
E
-
K
-
P
----------
R
L
---
F
A
D
RALINS
M
D
Q
N
M
F
R
N
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
348
Blastp_CBE
43.52
34%
-54
- C1 -
-
4RA5
4.5
-
KPCT_HUMAN
A:
[2-321]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
I
E
D
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
---
K
---
K
T
N
Q
F
F
A
I
K
A
L
K
K
D
V
V
-
L
M
D
D
D
V
E
C
T
M
V
-
E
K
R
V
L
S
L
--
A
W
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
---
Y
H
I
----
Q
S
----
C
--
H
--
K
--
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
---
C
----
K
-
E
NM
L
--
G
---
D
-
A
--
K
--
T
-
N
-
E
F
---
C
--
G
T
P
-----
D
Y
I
A
P
E
-
I
L
L
-
G
Q
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
H
---
G
Q
-
D
E
-
E
-
E
L
F
------
H
S
I
R
M
D
N
P
F
Y
P
R
W
L
E
K
E
A
K
-
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
-
R
G
-----
D
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
-----
K
V
K
S
P
F
D
C
S
N
F
D
K
E
FL
N
E
-
K
-
P
----------
R
L
---
F
A
D
RALINS
M
D
Q
N
M
F
R
N
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
563
HHSearch
43.50
38%
-47
- C1 -
-
2JDO
6.5
-
AKT2_HUMAN
A:
[6-339]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
---
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
-
I
A
K
D
E
V
A
H
T
V
T
-
E
S
R
V
L
Q
N
---
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
---
F
H
L
----
S
R
----
E
--
R
--
V
--
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
---
C
----
K
-
E
--
G
--
I
---
S
-
D
GA
T
--
M
-
K
-
T
F
---
C
--
G
T
P
-----
E
Y
L
A
P
E
-
V
L
E
D
-
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
-
R
-----
L
F
------
E
L
I
L
M
E
E
I
R
F
P
R
T
L
S
P
E
A
K
-
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
P
-
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
-----
S
E
V
D
T
R
Y
F
D
D
E
--
F
T
-
A
Q
S
----------
I
T
----------------
M
F
E
D
F
-
D
-
Y
-
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
491
Blastp_CBE
43.17
32%
-73
- C1 -
-
3TXO
6.9
-
KPCL_HUMAN
A:
[23-349]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
F
E
F
I
R
V
L
G
K
G
S
F
G
K
V
M
L
A
R
V
---
K
---
E
T
G
D
L
Y
A
V
K
V
L
K
K
D
V
I
-
L
Q
D
D
D
V
E
C
T
M
T
-
E
K
R
I
L
S
L
A
R
--
N
H
P
F
L
T
Q
L
F
C
C
F
Q
T
P
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
---
F
H
I
----
Q
K
----
S
--
R
--
R
--
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
-
K
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
H
E
G
H
C
K
L
A
D
F
G
M
---
C
KEGI-----------------------------
C
--
G
T
P
-----
D
Y
I
A
P
E
-
I
L
Q
E
-
M
L
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
A
P
F
E
A
E
N
E
D
-
D
L
-
F
-
E
---------
A
I
L
N
D
E
V
V
Y
P
T
W
L
H
E
D
A
T
-
G
I
L
K
S
F
M
T
K
N
P
T
M
R
L
G
S
L
T
Q
-
G
G
E
H
A
I
L
R
H
P
F
F
K
E
I
D
W
A
Q
L
N
H
R
Q
I
E
P
P
F
R
P
R
I
K
S
R
E
D
V
S
N
F
D
P
D
F
I
K
E
E
--
P
V
-
L
-
P
----------
I
D
EGH
L
P
M
------
I
N
Q
D
E
F
R
N
F
-
E
-
Y
-
V
S
P
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
325
Blastp_CBE
42.12
34%
-67
- C1 -
-
5F9E
7.3
-
B:
[16-335]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
I
E
D
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
---
K
---
K
T
N
Q
F
F
A
I
K
A
L
K
K
D
V
V
-
L
M
D
D
D
V
E
C
T
M
V
-
E
K
R
V
L
S
L
--
A
W
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
---
Y
H
I
----
Q
S
----
C
--
H
--
K
--
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
---
C
----
K
-
E
NM
L
--
G
---
D
-
A
--
K
--
T
-
N
-
E
F
---
C
--
G
T
P
-----
D
Y
I
A
P
E
-
I
L
L
-
G
Q
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
H
---
G
Q
-
D
E
-
E
-
E
L
F
------
H
S
I
R
M
D
N
P
F
Y
P
R
W
L
E
K
E
A
K
-
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
-
R
G
-----
D
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
-----
K
V
K
----------------------------------------------
N
M
F
R
N
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
500
Blastp_CBE
41.30
35%
-75
- C1 -
-
2PE2
2.8
-
PDPK1_HUMAN
A:
[8-285]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
K
E
N
K
V
P
Y
V
T
R
-
E
R
D
V
M
S
R
L
---
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
---
K
Y
I
----
R
K
----
I
--
G
--
S
--
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
---
A
----
K
-
V
--
L
--
S
-----------------F--
V
--
G
T
A
-----
Q
Y
V
S
P
E
-
L
L
T
E
K
S
A
C
K
S
S
D
L
W
-
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
---
A
G
-
N
E
-
Y
-
L
I
F
------
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
-
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
-
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
-
Q
Q
T
P
P
K
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
502
Blastp_CBE
41.25
35%
-74
- C1 -
-
2PE0
2.1
-
PDPK1_HUMAN
A:
[8-285]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
K
E
N
K
V
P
Y
V
T
R
-
E
R
D
V
M
S
R
L
---
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
---
K
Y
I
----
R
K
----
I
--
G
--
S
--
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
---
A
----
K
-
V
--
L
--
S
-----------------F--
V
--
G
T
A
-----
Q
Y
V
S
P
E
-
L
L
T
E
K
S
A
C
K
S
S
D
L
W
-
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
---
A
G
-
N
E
-
Y
-
L
I
F
------
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
-
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
-
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
-
Q
Q
T
P
P
K
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
127
Blastp_CBE
41.25
38%
-71
- C1 -
-
2R5T
6.7
-
SGK1_HUMAN
A:
[32-320]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
H
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
---
K
---
A
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
-
L
--------------
V
L
--
L
K
N
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
---
Y
H
L
----
Q
R
----
E
--
R
--
C
--
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
---
C
----
K
-
E
--
N
--
I
---
E
-
H
--
N
--
S
-
T
-
T
S
---
T
FC
G
T
P
-----
E
Y
L
A
P
E
-
V
L
H
K
-
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
T
A
-
E
M
-
Y
-
D
---------
N
I
L
N
K
P
L
Q
L
K
P
N
I
T
N
S
A
R
-
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
-
K
--
D
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
-----
N
V
S
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
511
Blastp_CBE
41.01
36%
-48
- C1 -
-
5DZC
4.1
-
?
A:
[532-844]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
H
E
L
E
T
E
R
I
I
G
R
G
T
F
G
T
V
K
L
V
H
H
---
K
---
P
T
Q
I
R
Y
A
L
K
C
V
S
K
R
S
I
I
S
L
N
Q
Q
N
N
I
K
L
E
-
R
E
I
----
T
A
E
N
D
H
P
F
I
I
R
L
V
R
T
F
K
D
S
N
C
F
Y
F
L
T
E
L
V
T
G
G
E
L
Y
---
D
A
I
----
R
K
----
L
--
G
--
L
--
L
S
K
P
Q
A
Q
F
Y
L
G
S
I
I
L
A
I
E
Y
L
H
E
-
R
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
K
Q
G
Y
V
K
L
I
D
F
G
C
---
A
----
K
-
K
--
I
------
Q
-
G
--
R
--
A
-
Y
-
T
L
---
V
--
G
T
P
-----
H
Y
M
A
P
E
-
V
I
L
-
G
K
G
Y
G
C
T
V
D
I
W
A
L
G
V
C
L
Y
E
F
I
C
G
P
L
P
F
G
N
D
Q
-
E
-
D
Q
-
L
-
E
I
F
------
R
D
I
L
T
G
Q
L
T
F
P
D
Y
V
S
D
Q
D
S
I
N
L
M
K
R
L
L
C
R
L
P
Q
G
R
I
G
C
-
S
I
-
N
G
F
K
D
I
K
E
H
A
F
F
G
N
F
N
W
D
K
L
A
G
R
L
L
E
P
P
L
V
-
S
K
G
E
T
Y
A
E
D
-
I
D
I
K
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
501
Blastp_CBE
40.77
35%
-72
- C1 -
-
2PE1
3.1
-
PDPK1_HUMAN
A:
[8-285]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
K
E
N
K
V
P
Y
V
T
R
-
E
R
D
V
M
S
R
L
---
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
---
K
Y
I
----
R
K
----
I
--
G
--
S
--
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
---
A
----
K
-
V
--
L
--
S
-----------------F--
V
--
G
T
A
-----
Q
Y
V
S
P
E
-
L
L
T
E
K
S
A
C
K
S
S
D
L
W
-
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
---
A
G
-
N
E
-
Y
-
L
I
F
------
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
-
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
-
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
-
Q
Q
T
P
P
K
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
126
Blastp_CBE
40.42
38%
-66
- C1 -
-
3HDM
6.5
-
SGK1_HUMAN
A:
[32-320]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
H
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
---
K
---
A
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
-
L
--------------
V
L
--
L
K
N
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
---
Y
H
L
----
Q
R
----
E
--
R
--
C
--
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
---
C
----
K
-
E
--
N
--
I
---
E
-
H
--
N
--
S
-
T
-
T
S
---
T
FC
G
T
P
-----
E
Y
L
A
P
E
-
V
L
H
K
-
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
T
A
-
E
M
-
Y
-
D
---------
N
I
L
N
K
P
L
Q
L
K
P
N
I
T
N
S
A
R
-
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
-
K
--
D
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
-----
N
V
S
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
159
Blastp_CBE
40.18
34%
-27
- C1 -
-
2F7Z
7.0
-
KAPCA_BOVIN
E:
[17-337]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
-
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
---
S
H
L
----
R
R
----
I
--
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----
K
-
R
--
V
------
K
-
G
--
R
--
T
-
W
-
T
L
---
C
--
G
T
P
-----
E
Y
L
A
P
E
I
I
L
S
K
G
--
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
-
Q
I
-
Y
-
E
---------
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
--
D
Y
E
E
E
--
E
I
-
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
517
Blastp_CBE
40.16
35%
-68
- C1 -
-
3RWP
7.1
-
PDPK1_HUMAN
A:
[33-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
K
E
N
K
V
P
Y
V
T
R
-
E
R
D
V
M
S
R
L
---
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
---
K
Y
I
----
R
K
----
I
--
G
--
S
--
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
---
A
----
K
-
V
--
L
--
S
-----------------NF-
V
--
G
T
A
-----
Q
Y
V
S
P
E
-
L
L
T
E
K
S
A
C
K
S
S
D
L
W
-
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
---
A
G
-
N
E
-
Y
-
L
I
F
------
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
-
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
-
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
-
Q
Q
T
P
P
K
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
359
Blastp_CBE
40.09
32%
-86
- C1 -
-
5LIH
2.8
-
KPCI_HUMAN
A:
[2-321]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
L
---
K
---
K
T
D
R
I
Y
A
M
K
V
V
K
K
E
L
V
--------
W
V
Q
T
-
E
K
H
V
F
E
Q
A
S
--
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
---
F
H
M
----
Q
R
----
Q
--
R
--
K
--
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
---
C
----
K
-
E
--
G
--
L
---
R
-
P
--
G
--
D
-
T
-
T
S
---
F
C-
G
T
P
-----
N
Y
I
A
P
E
-
I
L
-
R
G
E
D
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
D
I
V
-----------
N
TEDYLF
Q
V
I
L
E
K
Q
I
R
I
P
R
S
L
S
V
K
A
A
-
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
-
H
P
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
-----
N
I
S
G
E
F
G
L
D
N
F
D
S
Q
--
F
T
N
E
-
P
----------
V
Q
---
L
P
D
------
D
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
125
Blastp_CBE
40.06
38%
-70
- C1 -
-
3HDN
6.9
-
SGK1_HUMAN
A:
[32-316]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
H
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
---
K
---
A
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
-
L
--------------
V
L
--
L
K
N
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
---
Y
H
L
----
Q
R
----
E
--
R
--
C
--
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
---
C
----
K
-
E
--
N
--
I
---
E
-
H
--
N
--
S
-
T
-
T
S
---
T
FC
G
T
P
-----
E
Y
L
A
P
E
-
V
L
H
K
-
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
T
A
-
E
M
-
Y
-
D
---------
N
I
L
N
K
P
L
Q
L
K
P
N
I
T
N
S
A
R
-
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
-
K
--
D
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
345
Blastp_CBE
39.50
32%
-76
- C1 -
-
3ZH8
2.8
-
KPCI_HUMAN
B:
[2-336]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
L
---
K
---
K
T
D
R
I
Y
A
M
K
V
V
K
K
E
L
V
-
N
D
D
E
D
I
D
W
V
Q
T
-
E
K
H
V
F
E
Q
A
S
--
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
---
F
H
M
----
Q
R
----
Q
--
R
--
K
--
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
---
C
----
K
-
E
--
G
--
L
---
R
-
P
--
G
--
D
-
T
-
T
S
---
F
C-
G
T
P
-----
N
Y
I
A
P
E
-
I
L
-
R
G
E
D
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
D
I
V
G
-----------TEDYLF
Q
V
I
L
E
K
Q
I
R
I
P
R
S
L
S
V
K
A
A
-
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
-
H
P
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
-----
N
I
S
G
E
F
G
L
D
N
F
D
S
Q
--
F
T
N
E
-
P
----------
V
Q
---
L
P
D
------
D
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
357
Blastp_CBE
39.40
32%
-73
- C1 -
-
5LI9
2.8
-
KPCI_HUMAN
A:
[3-322]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
L
---
K
---
K
T
D
R
I
Y
A
M
K
V
V
K
K
E
L
V
-
N
D
D
E
D
I
D
W
V
Q
T
-
E
K
H
V
F
E
Q
A
S
--
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
---
F
H
M
----
Q
R
----
Q
--
R
--
K
--
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
---
C
----
K
-
E
--
G
--
L
---
R
-
P
--
G
--
D
-
T
-
T
S
---
F
C-
G
T
P
-----
N
Y
I
A
P
E
-
I
L
-
R
G
E
D
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
D
--------------EDYLF-
Q
V
I
L
E
K
Q
I
R
I
P
R
S
L
S
V
K
A
A
-
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
-
H
P
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
-----
N
I
S
G
E
F
G
L
D
N
F
D
S
Q
--
F
T
N
E
-
P
----------
V
Q
---
L
P
D
------
D
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
522
Blastp_CBE
39.37
35%
-66
- C1 -
-
2XCH
2.4
-
PDPK1_HUMAN
A:
[31-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
K
E
N
K
V
P
Y
V
T
R
-
E
R
D
V
M
S
R
L
---
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
---
K
Y
I
----
R
K
----
I
--
G
--
S
--
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
---
A
----
K
-
V
--
L
--
S
-----------------ANF
V
--
G
T
A
-----
Q
Y
V
S
P
E
-
L
L
T
E
K
S
A
C
K
S
S
D
L
W
-
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
---
A
G
-
N
E
-
Y
-
L
I
F
------
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
-
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
-
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
-
Q
Q
T
P
P
K
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
492
Blastp_CBE
39.35
32%
-56
- C1 -
-
3PFQ
4.4
-
KPCB_RAT
A:
[292-651]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
L
T
D
F
N
F
L
M
V
L
G
K
G
S
F
G
K
V
M
L
S
E
R
---
K
---
G
T
D
E
L
Y
A
V
K
I
L
K
K
D
V
V
-
I
Q
D
D
D
V
E
C
T
M
V
-
E
K
R
V
L
A
L
--
P
G
K
P
P
F
L
T
Q
L
H
S
C
F
Q
T
M
D
R
L
Y
F
V
M
E
Y
V
N
G
G
D
L
M
---
Y
H
I
----
Q
Q
----
V
--
G
--
R
--
F
K
E
P
H
A
V
F
Y
A
A
E
I
A
I
G
L
F
F
L
Q
S
-
K
G
I
I
Y
R
D
L
K
L
D
N
V
M
L
D
S
E
G
H
I
K
I
A
D
F
G
M
---
C
----
K
E
N
--
I
--
W
---
D
-
G
--
V
--
T
-
T
-
K
F
---
C
--
G
T
P
-----
D
Y
I
A
P
E
-
I
I
A
Y
-
Q
P
Y
G
K
S
V
D
W
W
A
F
G
V
L
L
Y
E
M
L
A
G
Q
A
P
F
---
E
G
E
-
D
E
-
D
-
E
L
F
------
Q
S
I
M
E
H
N
V
A
Y
P
K
S
M
S
K
E
A
V
-
A
I
C
K
G
L
M
T
K
H
P
G
K
R
L
G
C
-
G
P
-
E
G
E
R
D
I
K
E
H
A
F
F
R
Y
I
D
W
E
K
L
E
R
K
E
I
Q
P
P
Y
K
P
K
A
S
G
R
N
A
E
N
------
F
D
R
F
--
F
T
-
R
-
H
----------
P
P
---
V
L
P
------
P
D
Q
E
V
I
R
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
528
Blastp_CBE
39.28
35%
-64
- C1 -
-
3SC1
4.3
-
PDPK1_HUMAN
A:
[33-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
K
E
N
K
V
P
Y
V
T
R
-
E
R
D
V
M
S
R
L
---
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
---
K
Y
I
----
R
K
----
I
--
G
--
S
--
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
---
A
----
K
-
V
--
L
--
S
-----------------ANF
V
--
G
T
A
-----
Q
Y
V
S
P
E
-
L
L
T
E
K
S
A
C
K
S
S
D
L
W
-
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
---
A
G
-
N
E
-
Y
-
L
I
F
------
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
-
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
-
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
-
Q
Q
T
P
P
K
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
169
Blastp_CBE
39.09
33%
-39
- C1 -
-
1XH8
10.5
-
KAPCA_BOVIN
A:
[16-347]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
-
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
---
S
H
L
----
R
R
----
I
--
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----
K
-
R
--
V
--
K
---
G
-
R
--
T
------
W
L
---
C
--
G
T
P
-----
E
Y
L
A
P
E
I
I
L
S
K
G
--
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
-
Q
I
-
Y
-
E
---------
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
--
E
E
-
E
-
E
----------
I
R
---
V
I
N
EK----
C
G
K
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
523
Blastp_CBE
39.07
35%
-64
- C1 -
-
1UU8
3.1
-
PDPK1_HUMAN
A:
[31-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
K
E
N
K
V
P
Y
V
T
R
-
E
R
D
V
M
S
R
L
---
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
---
K
Y
I
----
R
K
----
I
--
G
--
S
--
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
---
A
----
K
-
V
--
L
--
S
-----------------ANF
V
--
G
T
A
-----
Q
Y
V
S
P
E
-
L
L
T
E
K
S
A
C
K
S
S
D
L
W
-
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
---
A
G
-
N
E
-
Y
-
L
I
F
------
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
-
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
-
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
-
Q
Q
T
P
P
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
507
Blastp_CBE
39.06
35%
-63
- C1 -
-
1UU9
3.2
-
PDPK1_HUMAN
A:
[10-285]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
K
E
N
K
V
P
Y
V
T
R
-
E
R
D
V
M
S
R
L
---
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
---
K
Y
I
----
R
K
----
I
--
G
--
S
--
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
---
A
----
K
-
V
--
L
--
S
-----------------NF-
V
--
G
T
A
-----
Q
Y
V
S
P
E
-
L
L
T
E
K
S
A
C
K
S
S
D
L
W
-
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
---
A
G
-
N
E
-
Y
-
L
I
F
------
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
-
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
-
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
-
Q
Q
T
P
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
358
Blastp_CBE
38.06
32%
-72
- C1 -
-
5LIH
6.7
-
KPCI_HUMAN
B:
[2-321]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
L
---
K
---
K
T
D
R
I
Y
A
M
K
V
V
K
K
E
L
----------
V
Q
T
-
E
K
H
V
F
E
Q
A
S
--
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
---
F
H
M
----
Q
R
----
Q
--
R
--
K
--
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
---
C
----
K
-
E
--
G
--
L
---
R
-
P
--
G
--
D
-
T
-
T
S
---
F
C-
G
T
P
-----
N
Y
I
A
P
E
-
I
L
-
R
G
E
D
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
D
I
-------------EDYLF-
Q
V
I
L
E
K
Q
I
R
I
P
R
S
L
S
V
K
A
A
-
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
-
H
P
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
-----
N
I
S
G
E
F
G
L
D
N
F
D
S
Q
--
F
T
N
E
-
P
----------
V
Q
---
L
P
D
------
D
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
154
Blastp_CBE
37.68
33%
-40
- C1 -
-
2GNL
5.7
-
KAPCA_BOVIN
A:
[16-347]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
-
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
---
S
H
L
----
R
R
----
I
--
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
K
V
A
D
F
G
F
---
A
----
K
-
R
--
V
--
K
---
G
-
R
--
T
------
W
L
---
C
--
G
T
P
-----
E
Y
L
A
P
E
I
I
L
S
K
G
--
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
-
Q
I
-
Y
-
E
---------
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
--
E
E
-
E
-
E
----------
I
R
---
V
I
N
EK----
C
G
K
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
132
Blastp_CBE
37.67
33%
-42
- C1 -
-
2GNF
4.9
-
KAPCA_BOVIN
A:
[16-347]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
-
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
---
S
H
L
----
R
R
----
I
--
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
K
V
A
D
F
G
F
---
A
----
K
-
R
--
V
--
K
---
G
-
R
--
T
------
W
L
---
C
--
G
T
P
-----
E
Y
L
A
P
E
I
I
L
S
K
G
--
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
-
Q
I
-
Y
-
E
---------
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
--
E
E
-
E
-
E
----------
I
R
---
V
I
N
EK----
C
G
K
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129
Blastp_CBE
37.54
33%
-39
- C1 -
-
2GNH
6.1
-
KAPCA_BOVIN
A:
[16-347]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
-
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
---
S
H
L
----
R
R
----
I
--
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
K
V
A
D
F
G
F
---
A
----
K
-
R
--
V
--
K
---
G
-
R
--
T
------
W
L
---
C
--
G
T
P
-----
E
Y
L
A
P
E
I
I
L
S
K
G
--
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
-
Q
I
-
Y
-
E
---------
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
--
E
E
-
E
-
E
----------
I
R
---
V
I
N
EK----
C
G
K
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
505
Blastp_CBE
37.32
35%
-73
- C1 -
-
1H1W
2.0
-
PDPK1_HUMAN
A:
[11-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
K
E
N
K
V
P
Y
V
T
R
-
E
R
D
V
M
S
R
L
---
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
---
K
Y
I
----
R
K
----
I
--
G
--
S
--
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
---
A
----
K
-
V
--
L
--
S
---
P
-----------
A
R
ANF
V
--
G
T
A
-----
Q
Y
V
S
P
E
-
L
L
T
E
K
S
A
C
K
S
S
D
L
W
-
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
---
A
G
-
N
E
-
Y
-
L
I
F
------
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
-
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
-
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
-
Q
Q
T
P
P
K
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
128
Blastp_CBE
37.29
33%
-39
- C1 -
-
2GNI
5.6
-
KAPCA_BOVIN
A:
[16-347]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
-
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
---
S
H
L
----
R
R
----
I
--
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
K
V
A
D
F
G
F
---
A
----
K
-
R
--
V
--
K
---
G
-
R
--
T
------
W
L
---
C
--
G
T
P
-----
E
Y
L
A
P
E
I
I
L
S
K
G
--
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
-
Q
I
-
Y
-
E
---------
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
--
E
E
-
E
-
E
----------
I
R
---
V
I
N
EK----
C
G
K
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
368
Blastp_CBE
37.06
33%
-70
- C1 -
-
1XJD
6.6
-
A:
[16-333]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
D
F
I
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
---
K
---
K
T
N
Q
F
F
A
I
K
A
L
K
K
D
V
V
-
L
M
D
D
D
V
E
C
T
M
V
-
E
K
R
V
L
S
L
--
A
W
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
---
Y
H
I
----
Q
S
----
C
--
H
--
K
--
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
---
C
----
K
-
E
--
N
--
M
---
L
-
G
--
D
--
A
-
K
-
T
N
---
F
C-
G
T
P
-----
D
Y
I
A
P
E
-
I
L
L
-
G
Q
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
H
---
G
Q
-
D
E
-
E
-
E
L
F
------
H
S
I
R
M
D
N
P
F
Y
P
R
W
L
E
K
E
A
K
-
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
-
R
G
-----
D
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
P
---------------------------------------------------------
N
M
F
R
N
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
504
Blastp_CBE
37.05
35%
-72
- C1 -
-
1UVR
3.0
-
PDPK1_HUMAN
A:
[11-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
K
E
N
K
V
P
Y
V
T
R
-
E
R
D
V
M
S
R
L
---
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
---
K
Y
I
----
R
K
----
I
--
G
--
S
--
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
---
A
----
K
-
V
--
L
--
S
---
P
-----------
A
R
ANF
V
--
G
T
A
-----
Q
Y
V
S
P
E
-
L
L
T
E
K
S
A
C
K
S
S
D
L
W
-
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
---
A
G
-
N
E
-
Y
-
L
I
F
------
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
-
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
-
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
-
Q
Q
T
P
P
K
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
193
Blastp_CBE
36.95
33%
-34
- C1 -
-
4IE9
3.5
-
KAPCA_BOVIN
A:
[17-348]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
-
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
---
S
H
L
----
R
R
----
I
--
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----
K
-
R
--
V
--
K
---
G
-
R
--
T
------
W
L
---
C
--
G
T
P
-----
E
Y
L
A
P
E
I
I
L
S
K
G
--
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
-
Q
I
-
Y
-
E
---------
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
--
E
E
-
E
-
E
----------
I
R
---
V
I
N
EK----
C
G
K
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
378
Blastp_CBE
36.84
31%
-34
- C1 -
-
4X6R
Error
-
KAPCA_MOUSE
A:
[7-347]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
K
---
E
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
-
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
---
S
H
L
----
R
R
----
I
--
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----
K
-
R
--
V
--
K
---
G
-
R
--
T
------
W
L
---
C
--
G
T
P
-----
E
Y
L
A
P
E
I
I
L
S
K
G
--
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
-
Q
I
-
Y
-
E
---------
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
--
E
E
-
E
-
E
----------
I
R
---
V
I
N
EK----
C
G
K
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
252
Blastp_CBE
36.51
32%
-31
- C1 -
-
1SMH
3.2
-
KAPCA_BOVIN
A:
[16-347]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
E
I
E
H
-
T
L
N
-
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
---
S
H
L
----
R
R
----
I
--
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
L
---
A
----
K
-
R
--
V
--
K
---
G
-
R
--
T
------
W
L
---
C
--
G
T
P
-----
E
Y
L
A
P
E
I
I
L
S
K
G
--
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
-
Q
I
-
Y
-
E
---------
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
--
E
E
-
E
-
E
----------
I
R
---
V
I
N
EK----
C
G
K
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
Blastp_CBE
36.44
38%
-8
- C1 -
-
4NW5
6.5
-
KS6A3_HUMAN
A:
[30-322]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
---
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
D
R
V
R
T
K
M
E
-
R
D
I
L
V
E
V
----
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
---
T
R
L
----
S
K
----
E
--
V
--
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
---
S
----
K
-
E
--
S
ID
H
---
E
-
K
--
K
--
A
-
Y
-
S
F
---
C
--
G
T
V
-----
E
Y
M
A
P
E
-
V
V
N
R
-
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
G
K
-
D
R
-
K
-
E
T
M
------
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
-
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
-
G
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------
T
F
Y
F
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
529
Blastp_CBE
36.31
35%
-69
- C1 -
-
3RWQ
6.3
-
PDPK1_HUMAN
A:
[33-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
K
E
N
K
V
P
Y
V
T
R
-
E
R
D
V
M
S
R
L
---
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
---
K
Y
I
----
R
K
----
I
--
G
--
S
--
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
---
A
----
K
-
V
--
L
--
S
---
P
-----------
A
R
ANF
V
--
G
T
A
-----
Q
Y
V
S
P
E
-
L
L
T
E
K
S
A
C
K
S
S
D
L
W
-
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
---
A
G
-
N
E
-
Y
-
L
I
F
------
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
-
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
-
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
-
Q
Q
T
P
P
K
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
480
Blastp_CBE
36.17
33%
-34
- C1 -
-
5N37
3.4
-
KAPCA_CRIGR
A:
[43-350]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
K
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
-
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
---
S
H
L
----
R
R
----
I
--
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----
K
-
R
--
V
--
K
---
G
-
R
--
T
------
W
L
---
C
--
G
T
P
-----
E
Y
L
A
P
E
I
I
L
S
K
G
--
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
-
Q
I
-
Y
-
E
---------
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
--
E
E
-
E
-
E
----------
I
R
---
V
I
N
EK----
C
G
K
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
Blastp_CBE
36.17
38%
-4
- C1 -
-
4NW6
7.4
-
KS6A3_HUMAN
A:
[30-322]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
---
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
D
R
V
R
T
K
M
E
-
R
D
I
L
V
E
V
----
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
---
T
R
L
----
S
K
----
E
--
V
--
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
---
S
----
K
-
E
--
S
ID
H
---
E
-
K
--
K
--
A
-
Y
-
S
F
---
C
--
G
T
V
-----
E
Y
M
A
P
E
-
V
V
N
R
-
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
G
K
-
D
R
-
K
-
E
T
M
------
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
-
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
-
G
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------
T
F
Y
F
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
308
Blastp_CBE
35.93
34%
-31
- C1 -
-
5LCR
2.8
-
KAPCA_CRIGR
A:
[43-350]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
K
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
-
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
---
S
H
L
----
R
R
----
I
--
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----
K
-
R
--
V
--
K
---
G
-
R
--
T
------
W
L
---
C
--
G
T
P
-----
E
Y
L
A
P
E
I
I
L
S
K
G
--
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
-
Q
I
-
Y
-
E
---------
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
--
E
E
-
E
-
E
----------
I
R
---
V
I
N
EK----
C
G
K
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
485
Blastp_CBE
35.86
33%
-35
- C1 -
-
5N1M
3.3
-
KAPCA_CRIGR
A:
[43-350]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
K
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
-
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
---
S
H
L
----
R
R
----
I
--
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----
K
-
R
--
V
--
K
---
G
-
R
--
T
------
W
L
---
C
--
G
T
P
-----
E
Y
L
A
P
E
I
I
L
S
K
G
--
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
-
Q
I
-
Y
-
E
---------
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
--
E
E
-
E
-
E
----------
I
R
---
V
I
N
EK----
C
G
K
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
Blastp_CBE
35.84
38%
-6
- C1 -
-
4NUS
7.2
-
KS6A3_HUMAN
A:
[30-322]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
---
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
D
R
V
R
T
K
M
E
-
R
D
I
L
V
E
V
----
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
---
T
R
L
----
S
K
----
E
--
V
--
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
---
S
----
K
-
E
--
S
ID
H
---
E
-
K
--
K
--
A
-
Y
-
S
F
---
C
--
G
T
V
-----
E
Y
M
A
P
E
-
V
V
N
R
-
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
G
K
-
D
R
-
K
-
E
T
M
------
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
-
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
-
G
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
------
T
F
Y
F
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
486
Blastp_CBE
35.83
33%
-33
- C1 -
-
5N1L
3.4
-
KAPCA_CRIGR
A:
[43-350]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
K
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
-
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
---
S
H
L
----
R
R
----
I
--
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----
K
-
R
--
V
--
K
---
G
-
R
--
T
------
W
L
---
C
--
G
T
P
-----
E
Y
L
A
P
E
I
I
L
S
K
G
--
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
-
Q
I
-
Y
-
E
---------
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
--
E
E
-
E
-
E
----------
I
R
---
V
I
N
EK----
C
G
K
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
242
Blastp_CBE
35.70
34%
-31
- C1 -
-
3OWP
5.9
-
KAPCA_HUMAN
A:
[41-348]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
K
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
-
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
---
S
H
L
----
R
R
----
I
--
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----
K
-
R
--
V
--
K
---
G
-
R
--
T
------
W
L
---
C
--
G
T
P
-----
E
Y
L
A
P
E
I
I
L
S
K
G
--
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
-
Q
I
-
Y
-
E
---------
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
--
E
E
-
E
-
E
----------
I
R
---
V
I
N
EK----
C
G
K
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
243
Blastp_CBE
35.67
34%
-32
- C1 -
-
3OVV
3.3
-
KAPCA_HUMAN
A:
[41-348]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
K
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
-
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
---
S
H
L
----
R
R
----
I
--
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----
K
-
R
--
V
--
K
---
G
-
R
--
T
------
W
L
---
C
--
G
T
P
-----
E
Y
L
A
P
E
I
I
L
S
K
G
--
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
-
Q
I
-
Y
-
E
---------
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
--
E
E
-
E
-
E
----------
I
R
---
V
I
N
EK----
C
G
K
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
451
Blastp_CBE
35.65
33%
-31
- C1 -
-
5OUC
3.0
-
KAPCA_CRIGR
A:
[43-350]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
K
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
-
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
---
S
H
L
----
R
R
----
I
--
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----
K
-
R
--
V
--
K
---
G
-
R
--
T
------
W
L
---
C
--
G
T
P
-----
E
Y
L
A
P
E
I
I
L
S
K
G
--
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
-
Q
I
-
Y
-
E
---------
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
--
E
E
-
E
-
E
----------
I
R
---
V
I
N
EK----
C
G
K
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
295
Blastp_CBE
35.59
34%
-30
- C1 -
-
5N1E
3.4
-
KAPCA_CRIGR
A:
[43-350]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
K
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
-
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
---
S
H
L
----
R
R
----
I
--
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----
K
-
R
--
V
--
K
---
G
-
R
--
T
------
W
L
---
C
--
G
T
P
-----
E
Y
L
A
P
E
I
I
L
S
K
G
--
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
-
Q
I
-
Y
-
E
---------
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
--
E
E
-
E
-
E
----------
I
R
---
V
I
N
EK----
C
G
K
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
302
Blastp_CBE
35.53
34%
-32
- C1 -
-
5M0U
Error
-
KAPCA_CRIGR
A:
[43-350]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
H
F
D
R
I
K
T
L
G
----
G
R
V
M
L
V
K
H
---
K
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
-
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
---
S
H
L
----
R
R
----
I
--
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----
K
-
R
--
V
--
K
---
G
-
R
--
T
------
W
L
---
C
--
G
T
P
-----
E
Y
L
A
P
E
I
I
L
S
K
G
--
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
-
Q
I
-
Y
-
E
---------
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
--
E
E
-
E
-
E
----------
I
R
---
V
I
N
EK----
C
G
K
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
454
Blastp_CBE
35.19
33%
-31
- C1 -
-
5OT3
3.1
-
KAPCA_CRIGR
A:
[43-350]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
K
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
-
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
---
S
H
L
----
R
R
----
I
--
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----
K
-
R
--
V
--
K
---
G
-
R
--
T
------
W
L
---
C
--
G
T
P
-----
E
Y
L
A
P
E
I
I
L
S
K
G
--
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
-
Q
I
-
Y
-
E
---------
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
--
E
E
-
E
-
E
----------
I
R
---
V
I
N
EK----
C
G
K
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
226
Blastp_CBE
35.17
33%
-32
- C1 -
-
6MM7
3.2
-
KAPCA_MOUSE
A:
[29-336]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
K
---
E
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
-
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
---
S
H
L
----
R
R
----
I
--
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----
K
-
R
--
V
--
K
---
G
-
R
--
T
------
W
L
---
C
--
G
T
P
-----
E
Y
L
A
P
E
I
I
L
S
K
G
--
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
-
Q
I
-
Y
-
E
---------
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
--------
D
D
Y
--
E
E
-
E
-
E
----------
I
R
---
V
I
N
EK----
C
G
K
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
239
Blastp_CBE
35.09
34%
-33
- C1 -
-
3POO
3.3
-
KAPCA_HUMAN
A:
[41-348]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
K
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
-
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
---
S
H
L
----
R
R
----
I
--
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----
K
-
R
--
V
--
K
---
G
-
R
--
T
------
W
L
---
C
--
G
T
P
-----
E
Y
L
A
P
E
I
I
L
S
K
G
--
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
-
Q
I
-
Y
-
E
---------
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
----
T
S
N
F
D
D
Y
--
E
E
-
E
-
E
----------
I
R
---
V
I
N
EK----
C
G
K
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
120
Blastp_CBE
35.00
39%
-25
- C1 -
-
6G78
5.7
-
KS6A6_HUMAN
B:
[30-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
KTG
P
---
D
A
G
Q
L
Y
A
M
K
V
L
K
K
A
S
L
-
K
V
R
D
---------
D
I
L
V
E
V
----
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
---
T
R
L
----
S
K
----
E
--
V
--
L
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
E
I
G
H
I
K
L
T
D
F
G
L
---
S
----
K
-
E
--
S
V-------------------------
G
T
V
-----
E
Y
M
A
P
E
-
V
V
N
R
-
R
G
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
G
K
-
D
R
-
N
-
E
T
M
------
N
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
A
E
A
Q
-
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
S
-
E
---
G
V
E
E
I
K
R
H
L
F
F
A
N
I
D
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
Blastp_CBE
35.00
39%
-22
- C1 -
-
3QKM
9.1
-
AKT1_HUMAN
A:
[6-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
---
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
A
K
D
E
V
A
H
T
L
T
-
E
N
R
V
L
Q
---
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
---
F
H
L
----
S
R
----
E
--
R
--
V
--
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
---
C
----
K
-
E
--
G
--
I
---
K
-
D
--
G
--
A
-
T
-
M
K
---
F
C-
G
T
P
-----
E
Y
L
A
P
E
-
V
L
E
D
N
D
-
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
---
Q
-
D
H
-
E
-
K
L
F
------
E
L
I
L
M
E
E
I
R
F
P
R
T
L
G
P
E
A
K
-
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
--
F
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
472
Blastp_CBE
34.99
33%
-30
- C1 -
-
5N3G
4.1
-
KAPCA_CRIGR
A:
[43-350]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
K
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
-
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
---
S
H
L
----
R
R
----
I
--
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----
K
-
R
--
V
--
K
---
G
-
R
--
T
------
W
L
---
C
--
G
T
P
-----
E
Y
L
A
P
E
I
I
L
S
K
G
--
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
-
Q
I
-
Y
-
E
---------
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
--
E
E
-
E
-
E
----------
I
R
---
V
I
N
EK----
C
G
K
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
Blastp_CBE
34.94
38%
-3
- C1 -
-
5D9L
4.4
-
KS6A3_HUMAN
A:
[30-322]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
---
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
D
R
V
R
T
K
M
E
-
R
D
I
L
V
E
V
----
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
---
T
R
L
----
S
K
----
E
--
V
--
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
---
S
----
K
-
E
-----------------------------
G
T
V
-----
E
Y
M
A
P
E
-
V
V
N
R
-
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
G
K
-
D
R
-
K
-
E
T
M
------
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
-
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
-
G
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
T
G
R
P
E
D
T
F
Y
F
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
Blastp_CBE
34.93
39%
-18
- C1 -
-
4EKL
7.3
-
AKT1_HUMAN
A:
[6-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
---
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
A
K
D
E
V
A
H
T
L
T
-
E
N
R
V
L
Q
---
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
---
F
H
L
----
S
R
----
E
--
R
--
V
--
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
---
C
----
K
-
E
--
G
--
I
---
K
-
D
--
G
--
A
-
T
-
M
K
---
F
C-
G
T
P
-----
E
Y
L
A
P
E
-
V
L
E
D
N
D
-
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
---
Q
-
D
H
-
E
-
K
L
F
------
E
L
I
L
M
E
E
I
R
F
P
R
T
L
G
P
E
A
K
-
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
--
F
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
Blastp_CBE
34.88
39%
-22
- C1 -
-
4GV1
6.7
-
AKT1_HUMAN
A:
[3-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
---
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
A
K
D
E
V
A
H
T
L
T
-
E
N
R
V
L
Q
---
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
---
F
H
L
----
S
R
----
E
--
R
--
V
--
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
---
C
----
K
-
E
--
G
--
I
---
K
-
D
--
G
--
A
-
T
-
M
K
---
F
C-
G
T
P
-----
E
Y
L
A
P
E
-
V
L
E
D
N
D
-
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
---
Q
-
D
H
-
E
-
K
L
F
------
E
L
I
L
M
E
E
I
R
F
P
R
T
L
G
P
E
A
K
-
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
-----
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
--
F
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
Blastp_CBE
34.80
38%
-20
- C1 -
-
3G51
5.9
-
KS6A3_MOUSE
A:
[24-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
---
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
----------
R
D
I
L
V
E
V
----
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
---
T
R
L
----
S
K
----
E
--
V
--
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
---
S
----
K
-
E
--
S
I--------------------------
T
V
-----
E
Y
M
A
P
E
-
V
V
N
R
-
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
G
K
-
D
R
-
K
-
E
T
M
------
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
-
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
-
G
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
402
Blastp_CBE
34.71
33%
-30
- C1 -
-
1L3R
2.8
-
KAPCA_MOUSE
E:
[40-347]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
K
---
E
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
-
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
---
S
H
L
----
R
R
----
I
--
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----
K
-
R
--
V
--
K
---
G
-
R
--
T
------
W
L
---
C
--
G
T
P
-----
E
Y
L
A
P
E
I
I
L
S
K
G
--
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
-
Q
I
-
Y
-
E
---------
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
--
E
E
-
E
-
E
----------
I
R
---
V
I
N
EK----
C
G
K
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
255
Blastp_CBE
34.61
34%
-24
- C1 -
-
6C0U
3.4
-
KAPCA_HUMAN
A:
[44-351]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
K
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
-
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
---
S
H
L
----
R
R
----
I
--
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----
K
-
R
--
V
--
K
---
G
-
R
--
T
------
W
L
---
C
--
G
T
P
-----
E
Y
L
A
P
E
I
I
L
S
K
G
--
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
-
Q
I
-
Y
-
E
---------
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
--
E
E
-
E
-
E
----------
I
R
---
V
I
N
EK----
C
G
K
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
294
Blastp_CBE
34.37
34%
-29
- C1 -
-
5N1K
3.5
-
KAPCA_CRIGR
A:
[43-350]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
K
----
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
-
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
---
S
H
L
----
R
R
----
I
--
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----
K
-
R
--
V
--
K
---
G
-
R
--
T
------
W
L
---
C
--
G
T
P
-----
E
Y
L
A
P
E
I
I
L
S
K
G
--
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
-
Q
I
-
Y
-
E
---------
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
-
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
--
E
E
-
E
-
E
----------
I
R
---
V
I
N
EK----
C
G
K
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
121
Blastp_CBE
34.26
39%
-14
- C1 -
-
6G78
7.5
-
KS6A6_HUMAN
A:
[30-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
KTG
P
---
D
A
G
Q
L
Y
A
M
K
V
L
K
K
A
S
L
-
K
V
R
D
---------
D
I
L
V
E
V
----
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
---
T
R
L
----
S
K
----
E
--
V
--
L
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
E
I
G
H
I
K
L
T
D
F
G
L
---
S
----
K
-
E
--
S
VD
Q
-----------------------
G
T
V
-----
E
Y
M
A
P
E
-
V
V
N
R
-
R
G
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
G
K
-
D
R
-
N
-
E
T
M
------
N
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
A
E
A
Q
-
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
S
-
E
---
G
V
E
E
I
K
R
H
L
F
F
A
N
I
D
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
119
Blastp_CBE
34.25
39%
-7
- C1 -
-
6G77
7.4
-
KS6A6_HUMAN
A:
[30-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
KTG
P
---
D
A
G
Q
L
Y
A
M
K
V
L
K
K
A
S
L
-
K
V
R
D
---------
D
I
L
V
E
V
----
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
---
T
R
L
----
S
K
----
E
--
V
--
L
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
E
I
G
H
I
K
L
T
D
F
G
L
---
S
----
K
-
E
--
S
VD
Q
---
E
-
K
--
K
--
A
-
Y
-
S
F
---
C
--
G
T
V
-----
E
Y
M
A
P
E
-
V
V
N
R
-
R
G
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
G
K
-
D
R
-
N
-
E
T
M
------
N
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
A
E
A
Q
-
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
S
-
E
---
G
V
E
E
I
K
R
H
L
F
F
A
N
I
D
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
Blastp_CBE
34.00
38%
-7
- C1 -
-
5D9K
6.4
-
KS6A3_HUMAN
A:
[30-322]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
---
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
D
R
V
R
T
K
M
E
-
R
D
I
L
V
E
V
----
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
---
T
R
L
----
S
K
----
E
--
V
--
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
---
S
----
K
----------------------------
C
--
G
T
V
-----
E
Y
M
A
P
E
-
V
V
N
R
-
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
G
K
-
D
R
-
K
-
E
T
M
------
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
-
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
-
G
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
------
T
F
Y
F
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
Blastp_CBE
33.74
38%
-1
- C1 -
-
5D9K
6.3
-
KS6A3_HUMAN
B:
[30-322]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
---
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
D
R
V
R
T
K
M
E
-
R
D
I
L
V
E
V
----
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
---
T
R
L
----
S
K
----
E
--
V
--
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
---
S
----
K
-
E
--------------------------
C
--
G
T
V
-----
E
Y
M
A
P
E
-
V
V
N
R
-
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
G
K
-
D
R
-
K
-
E
T
M
------
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
-
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
-
G
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------
T
F
Y
F
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
118
Blastp_CBE
33.39
39%
-3
- C1 -
-
6G77
7.1
-
KS6A6_HUMAN
B:
[30-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
KTG
P
---
D
A
G
Q
L
Y
A
M
K
V
L
K
K
A
S
L
-
K
V
R
D
---------
D
I
L
V
E
V
----
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
---
T
R
L
----
S
K
----
E
--
V
--
L
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
E
I
G
H
I
K
L
T
D
F
G
L
---
S
----
K
-
E
--
S
VD
Q
---
E
-
K
--
K
--
A
-
Y
-
S
F
---
C
--
G
T
V
-----
E
Y
M
A
P
E
-
V
V
N
R
-
R
G
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
G
K
-
D
R
-
N
-
E
T
M
------
N
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
A
E
A
Q
-
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
S
-
E
---
G
V
E
E
I
K
R
H
L
F
F
A
N
I
D
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
Blastp_CBE
33.29
39%
-11
- C1 -
-
4GUE
7.3
-
KS6A3_MOUSE
A:
[25-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
---
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
D
R
V
---------
L
V
E
V
----
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
---
T
R
L
----
S
K
----
E
--
V
--
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
---
S
----
K
-----------
E
-
K
--
K
--
A
-
Y
-
S
F
---
C
--
G
T
V
-----
E
Y
M
A
P
E
-
V
V
N
R
-
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
G
K
-
D
R
-
K
-
E
T
M
------
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
-
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
-
G
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
122
Blastp_CBE
33.28
39%
-27
- C1 -
-
6G76
6.3
-
KS6A6_HUMAN
B:
[30-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
KTG
P
---
D
A
G
Q
L
Y
A
M
K
V
L
K
K
A
S
L
-
K
V
----------
R
D
I
L
V
E
V
----
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
--
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
---
T
R
L
----
S
K
----
E
--
V
--
L
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
E
I
G
H
I
K
L
T
D
F
G
L
---
S
----
K
-
E
S-
V
--
D
-------------------------
V
-----
E
Y
M
A
P
E
-
V
V
N
R
-
R
G
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
G
K
-
D
R
-
N
-
E
T
--------------
L
G
M
P
Q
F
L
S
A
E
A
Q
-
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
S
-
E
---
G
V
E
E
I
K
R
H
L
F
F
A
N
I
D
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
116
Blastp_CBE
33.27
38%
-16
- C1 -
-
2Z7Q
4.6
-
KS6A1_HUMAN
A:
[28-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
---
V
TRP
D
S
G
H
L
Y
A
M
K
V
L
--------------------
I
L
A
D
V
----
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
---
T
R
L
----
S
K
----
E
--
V
--
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
SKE-------------------------------------
G
T
V
-----
E
Y
M
A
P
E
-
V
V
N
R
-
Q
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
---
Q
G
K
-
D
R
-
K
-
E
T
M
------
T
L
I
L
K
A
K
L
G
M
P
Q
F
L
S
T
E
A
Q
-
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
-
G
P
-
D
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
Blastp_CBE
33.20
39%
-8
- C1 -
-
4EL9
6.8
-
KS6A3_MOUSE
A:
[25-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
---
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
D
R
V
------
R
D
I
L
V
E
V
----
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
---
T
R
L
----
S
K
----
E
--
V
--
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
---
S
----
K
-
E
--
S
------
E
-
K
--
K
--
A
-
Y
-
S
F
---
C
--
G
T
V
-----
E
Y
M
A
P
E
-
V
V
N
R
-
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
G
K
-
D
R
-
K
-
E
T
M
------
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
-
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
-
G
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
Blastp_CBE
32.97
39%
-14
- C1 -
-
3UBD
7.5
-
KS6A3_MOUSE
A:
[24-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
---
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
D
R
V
-------
D
I
L
V
E
V
----
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
---
T
R
L
----
S
K
----
E
--
V
--
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
---
S
----
K
-----------
E
-
K
--
K
--
A
-
Y
-
S
F
---
C
--
G
T
V
-----
E
Y
M
A
P
E
-
V
V
N
R
-
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
G
K
-
D
R
-
K
-
E
T
M
------
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
-
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
-
G
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134
Blastp_CBE
32.66
38%
20
- C1 -
-
4L3J
7.3
-
KS6B1_HUMAN
A:
[20-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
---
N
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
-
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
---
M
Q
L
----
E
R
----
E
--
G
--
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
--------
C
-
K
--
E
--
S
IHD
G
-
T
--
V
--
T
-
H
-
T
F
---
C
--
G
T
I
-----
E
Y
M
A
P
E
-
I
L
M
R
-
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
-
K
T
----
I
D
------
K
I
-
L
K
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
-
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
153
Blastp_CBE
32.64
37%
12
- C1 -
-
3WE4
4.2
-
KS6B1_HUMAN
A:
[21-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
---
N
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
-
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
---
M
Q
L
----
E
R
----
E
--
G
--
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
---
C
----------------
K
-
E
--
S
--
I
-
H
-
D
-------
V
T
H
FCGTI
E
Y
M
A
P
E
-
I
L
M
R
-
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
-
K
T
----
I
D
------
K
I
-
L
K
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
-
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
114
Blastp_CBE
32.55
38%
-6
- C1 -
-
2Z7S
6.6
-
KS6A1_HUMAN
A:
[28-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
---
V
TRP
D
S
G
H
L
Y
A
M
K
V
L
K
-------------------
I
L
A
D
V
----
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
---
T
R
L
----
S
K
----
E
--
V
--
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
SKE-------------------------------------
G
T
V
-----
E
Y
M
A
P
E
-
V
V
N
R
-
Q
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
---
Q
G
K
-
D
R
-
K
-
E
T
M
------
T
L
I
L
K
A
K
L
G
M
P
Q
F
L
S
T
E
A
Q
-
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
-
G
P
-
D
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
115
Blastp_CBE
32.51
38%
-1
- C1 -
-
2Z7R
5.1
-
KS6A1_HUMAN
A:
[28-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
---
V
TRP
D
S
G
H
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
------------
I
L
A
D
V
----
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
---
T
R
L
----
S
K
----
E
--
V
--
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
SKE-------------------------------------
G
T
V
-----
E
Y
M
A
P
E
-
V
V
N
R
-
Q
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
---
Q
G
K
-
D
R
-
K
-
E
T
M
------
T
L
I
L
K
A
K
L
G
M
P
Q
F
L
S
T
E
A
Q
-
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
-
G
P
-
D
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
133
Blastp_CBE
32.02
38%
19
- C1 -
-
4L3L
7.3
-
KS6B1_HUMAN
A:
[20-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
---
N
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
-
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
---
M
Q
L
----
E
R
----
E
--
G
--
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
--------
C
-
K
--
E
--
S
IHD
G
-
T
--
V
--
T
-
H
-
T
F
---
C
--
G
T
I
-----
E
Y
M
A
P
E
-
I
L
M
R
-
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
-
K
T
----
I
D
------
K
I
-
L
K
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
-
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
131
Blastp_CBE
31.88
35%
26
- C1 -
-
4L42
7.2
-
KS6B1_HUMAN
A:
[20-343]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
---
N
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
-
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
---
M
Q
L
----
E
R
----
E
--
G
--
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
--------
C
-
K
--
E
--
S
IHD
G
-
T
--
V
--
T
-
H
-
T
F
---
C
--
G
T
I
-----
E
Y
M
A
P
E
-
I
L
M
R
-
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
-
K
T
----
I
D
------
K
I
-
L
K
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
-
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
-------------------------------------------------------
E
M
F
R
D
F
-
E
-
Y
-
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
139
Blastp_CBE
31.42
38%
-16
- C1 -
-
4RLO
2.7
-
KS6B1_HUMAN
B:
[7-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
---
N
T
G
K
I
F
A
M
K
V
L
K
K
------------------------
K
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
---
M
Q
L
----
E
R
----
E
--
G
--
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
--------
C
-
K
--
E
--
S
I-----------------------
T
I
-----
E
Y
M
A
P
E
-
I
L
M
R
-
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
-
K
T
----
I
D
------
K
I
-
L
K
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
-
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
135
Blastp_CBE
30.41
38%
6
- C1 -
-
3A61
6.6
-
KS6B1_HUMAN
A:
[19-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
---
N
T
G
K
I
F
A
M
K
V
L
----------------
K
A
E
R
N
I
L
E
E
V
K
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
---
M
Q
L
----
E
R
----
E
--
G
--
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
-----------------------------------------
G
T
I
-----
E
Y
M
A
P
E
-
I
L
M
R
-
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
-
K
T
----
I
D
------
K
I
-
L
K
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
-
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
145
Blastp_CBE
30.29
37%
15
- C1 -
-
3A62
7.7
-
KS6B1_HUMAN
A:
[19-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
---
N
T
G
K
I
F
A
M
K
V
L
K
K
---------------A
E
R
N
I
L
E
E
V
K
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
---
M
Q
L
----
E
R
----
E
--
G
--
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
---
C
----------------
K
-
E
--------------------FCGTI
E
Y
M
A
P
E
-
I
L
M
R
-
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
-
K
T
----
I
D
------
K
I
-
L
K
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
-
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
136
Blastp_CBE
30.10
38%
-7
- C1 -
-
3A60
6.4
-
KS6B1_HUMAN
B:
[19-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
---
N
T
G
K
I
F
A
M
K
V
L
K
K
------------------------
K
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
---
M
Q
L
----
E
R
----
E
--
G
--
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
--------
C
-
K
--
E
--
S
--------------------
C
--
G
T
I
-----
E
Y
M
A
P
E
-
I
L
M
R
-
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
-
K
T
----
I
D
------
K
I
-
L
K
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
-
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
123
Blastp_CBE
28.88
39%
-6
- C1 -
-
6G76
5.2
-
KS6A6_HUMAN
A:
[30-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
KTG
P
---
D
A
G
Q
L
Y
A
M
K
V
L
K
K
A
S
L
-
K
V
R
D
---------
D
I
L
V
E
V
----
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
---
T
R
L
----
S
K
----
E
--
V
--
L
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
E
I
G
H
I
K
L
T
D
F
G
L
---
S
----
K
-
E
S-
V
--
D
---
Q
-
E
--
K
--
K
-
A
-
Y
F
---
C
--
G
T
V
-----
E
Y
M
A
P
E
-
V
V
N
R
-
R
G
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
G
K
-
D
R
-
N
-
E
T
M
------
N
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
A
E
A
Q
-
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
S
-
E
---
G
V
E
E
I
K
R
H
L
F
F
A
N
I
D
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------