@TOME V3
(Feb 2022)

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Alignment:

3D Common Core:

Structural Clustering:

Modeller Result :

Complexes Modeling
Screening

Templates Information:
Sequence & Result Tab:

Values color: [ Good | Correct | Middling | Bad ]Sequence color : MutatedHelixStrandConserved

Query sequence : ATR_HUMAN: (2020-09-04 )
MGEHGLELASMIPALRELGSATPEEYNTVVQKPRQILCQFIDRILTDVNVVAVELVKKTDSQPTSVMLLDFIQHIMKSSPLMFVNVSGSHEAKGSCIEFSNWIITRLLRIAATPSCHLLHKKICEVICSLLFLFKSKSPAIFGVLTKELLQLFEDLVYLHRRNVMGHAVEWPVVMSRFLSQLDEHMGYLQSAPLQLMSMQNLEFIEVTLLMVLTRIIAIVFFRRQELLLWQIGCVLLEYGSPKIKSLAISFLTELFQLGGLPAQPASTFFSSFLELLKHLVEMDTDQLKLYEEPLSKLIKTLFPFEAEAYRNIEPVYLNMLLEKLCVMFEDGVLMRLKSDLLKAALCHLLQYFLKFVPAGYESALQVRKVYVRNICKALLDVLGIEVDAEYLLGPLYAALKMESMEIIEEIQCQTQQENLSSNSDGISPKRRRLSSSLNPSKRAPKQTEEIKHVDMNQKSILWSALKQKAESLQISLEYSGLKNPVIEMLEGIAVVLQLTALCTVHCSHQNMNCRTFKDCQHKSKKKPSVVITWMSLDFYTKVLKSCRSLLESVQKLDLEATIDKVVKIYDALIYMQVNSSFEDHILEDLCGMLSLPWIYSHSDDGCLKLTTFAANLLTLSCRISDSYSPQAQSRCVFLLTLFPRRIFLEWRTAVYNWALQSSHEVIRASCVSGFFILLQQQNSCNRVPKILIDKVKDDSDIVKKEFASILGQLVCTLHGMFYLTSSLTEPFSEHGHVDLFCRNLKATSQHECSSSQLKASVCKPFLFLLKKKIPSPVKLAFIDNLHHLCKHLDFREDETDVKAVLGTLLNLMEDPDKDVRVAFSGNIKHILESLDSEDGFIKELFVLRMKEAYTHAQISRNNELKDTLILTTGDIGRAAKGDLVPFALLHLLHCLLSKSASVSGAAYTEIRALVAAKSVKLQSFFSQYKKPICQFLVESLHSSQMTALPNTPCQNADVRKQDVAHQREMALNTLSEIANVFDFPDLNRFLTRTLQVLLPDLAAKASPAASALIRTLGKQLNVNRREILINNFKYIFSHLVCSCSKDELERALHYLKNETEIELGSLLRQDFQGLHNELLLRIGEHYQQVFNGLSILASFASSDDPYQGPRDIISPELMADYLQPKLLGILAFFNMQLLSSSVGIEDKKMALNSLMSLMKLMGPKHVSSVRVKMMTTLRTGLRFKDDFPELCCRAWDCFVRCLDHACLGSLLSHVIVALLPLIHIQPKETAAIFHYLIIENRDAVQDFLHEIYFLPDHPELKKIKAVLQEYRKETSESTDLQTTLQLSMKAIQHENVDVRIHALTSLKETLYKNQEKLIKYATDSETVEPIISQLVTVLLKGCQDANSQARLLCGECLGELGAIDPGRLDFSTTETQGKDFTFVTGVEDSSFAYGLLMELTRAYLAYADNSRAQDSAAYAIQELLSIYDCREMETNGPGHQLWRRFPEHVREILEPHLNTRYKSSQKSTDWSGVKKPIYLSKLGSNFAEWSASWAGYLITKVRHDLASKIFTCCSIMMKHDFKVTIYLLPHILVYVLLGCNQEDQQEVYAEIMAVLKHDDQHTINTQDIASDLCQLSTQTVFSMLDHLTQWARHKFQALKAEKCPHSKSNRNKVDSMVSTVDYEDYQSVTRFLDLIPQDTLAVASFRSKAYTRAVMHFESFITEKKQNIQEHLGFLQKLYAAMHEPDGVAGVSAIRKAEPSLKEQILEHESLGLLRDATACYDRAIQLEPDQIIHYHGVVKSMLGLGQLSTVITQVNGVHANRSEWTDELNTYRVEAAWKLSQWDLVENYLAADGKSTTWSVRLGQLLLSAKKRDITAFYDSLKLVRAEQIVPLSAASFERGSYQRGYEYIVRLHMLCELEHSIKPLFQHSPGDSSQEDSLNWVARLEMTQNSYRAKEPILALRRALLSLNKRPDYNEMVGECWLQSARVARKAGHHQTAYNALLNAGESRLAELYVERAKWLWSKGDVHQALIVLQKGVELCFPENETPPEGKNMLIHGRAMLLVGRFMEETANFESNAIMKKYKDVTACLPEWEDGHFYLAKYYDKLMPMVTDNKMEKQGDLIRYIVLHFGRSLQYGNQFIYQSMPRMLTLWLDYGTKAYEWEKAGRSDRVQMRNDLGKINKVITEHTNYLAPYQFLTAFSQLISRICHSHDEVFVVLMEIIAKVFLAYPQQAMWMMTAVSKSSYPMRVNRCKEILNKAIHMKKSLEKFVGDATRLTDKLLELCNKPVDGSSSTLSMSTHFKMLKKLVEEATFSEILIPLQSVMIPTLPSILGTHANHASHEPFPGHWAYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKELRQCMLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEWSKPVKGHSKAPLNETGEVVNEKAKTHVLDIEQRLQGVIKTRNRVTGLPLSIEGHVHYLIQEATDENLLCQMYLGWTPYM

Atome Classification :

(21 SA) .........10........20........30........40........50........60........70........80........90.....--...100.......110.......120.......130.......140-----........150.......160.......---------170.......180.......190.......200.......210.......220.......230.......240-.........250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370------.........380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......-510.......520.......530....--------...540.......550.......560.......570.......580.......590.......600.......610........620.......630.......640.......650.......660.......670.......680.......690......--.700....------...710.......720.......730.......740.......750...-------..-..760.....-..770---...--.....780.......790......-..800.......810.....---------..820.......830.......----840.......850.......860.......870.......880.......890.....--..-900.......910.......920........930.......940.......950.......960.......970.......980.......990.......1000...-...1010...-...1020...--------...1030......1040....-..1050-....----...-------1060.......1070......1080...-----...1090.....-------------.----1100......1110--.--...-....1120...-------------------...1130....------------------------.--.1140-.......1150......1160......1170......1180.....-.1190......1200......1210......1220-----........----.1230......1240....--.---.-1250-..-....-------.---------------1260.------.....1270-......-.-------1280--....--------....1290......-.1300....----------..1310.-.....1320...-.----------..1330.----.....1340--..-.---.--..1350-------......1360......1370.....-.-.1380......1390..-....-1400......1410......1420....-------..1430..-------....1440-......1450.......1460......---1470......1480......1490..-----....1500......1510......1520......1530......1540----......1550.--.....1560....---..1570......1580......1590......1600......1610......1620......1630-........1640......1650......1660----.----..----.----...---1670......1680......1690.....-.-.-1700...--...1710......--1720.......1730------.---------...------.....1740......1750...--...1760-....-.-..1770.....------.1780.-.....1790..-------.----...1800......1810----..-----..----...1820......1830......1840......1850......1860.-----.......1870---.----.......--1880.-.....1890-.........1900....--..1910...-----------.-----------..1920-------.........1930......1940....---..1950--------.----------------.---..---....1960.---.-..-..1970---------...----......1980.....-.1990.---.......2000......2010----.----.-------.---..---.2020-------......----...2030----.-------...------------.....2040......2050.------...------.---------------------.-----------------------------------------.-.---------2060......2070-----.......-.2080......2090--------......2100........2110..-------....2120......2130......2140......2150......2160.....--.2170......2180...--------.-------.-.2190----.........2200-..--.----...2210...------------...2220----------......----------.-------------2230-----------------.----------.---------.------------------.---.----.-----------.--------------.-------------.----------------2240-.----.-----------.----------------------------------.----------------------------------.----------------------------------.-------------..----------.--------------2250-----.....------------------------------.------------------------------..2260--.--.....2270.-------.....2280...---------...2290---.------........2300.-.-.....2310.....-----.2320.....--.--2330......2340......2350......2360......2370......2380......2390.....-.2400-----.------..--.---...--2410-...----.---..---..--.2420......2430.-......2440......2450......2460......2470......2480......2490...-----------...2500------..-------..-..-.-..2510......2520......-2530--.........2540......2550......2560..---...---.2570..-------..-----------------------------.---------------.2580----------.....------------....2590..---....2600..-....------2610----....------....2620......2630......2640.
(Atome) (Ident) (Tito) (Num) (QMean) (pKd) (pKd) (Uniprot) MGEHGLELASMIPALRELGSATPEEYNTVVQKPRQILCQFIDRILTDVNVVAVELVKKTDSQPTSVMLLDFIQHIMKSSPLMFVNVSGSHEAKGSC--IEFSNWIITRLLRIAATPSCHLLHKKICEVICSLLFLFKSKSPAI------FGVLTKELLQLFEDLVYLHRRNVMGHAV---------EWPVVMSRFLSQLDEHMGYLQSAPLQLMSMQNLEFIEVTLLMVLTRIIAIVFFRRQELLLWQIGCVLLEYG---SPKIKSLAISFLTELFQLGGLPAQPASTFFSSFLELLKHLVEMDTDQLKLYEEPLSKLIKTLFPFEAEAYRNIEPVYLNMLLEKLCVMFEDGVLMRLKSDLLKAALCHLLQYFLKFVPAGYESALQVRKV--------YVRNICKALLDVLGIEVDAEYLLGPLYAALKMESMEIIEEIQCQTQQENLSSNSDGISPKRRRLSSSLNPSKRAPKQTEEIKHVDMNQKSILWSALKQKAESLQISLEYSGLKNPVIEMLEGIAVVLQLTALCTVHCSH-QNMNCRTFKDCQHKSKKKPSVVITWMS--------LDFYTKVLKSCRSLLESVQKLDLEATIDKVVKIYDALIYMQVNSSFEDHILEDLCGMLSLPWIYSHSDDGCLKLT-TFAANLLTLSCRISDSYSPQAQSRCVFLLTLFPRRIFLEWRTAVYNWALQSSHEVIRASCVSGFFILLQQQNSCNRVPKILIDKVKD--DSDIVKKE------FASILGQLVCTLHGMFYLTSSLTEPFSEHGHVDLFCRNLKATSQHECSS-------SQ-LKASVCKPFL-FLLK----KKI--PSPVKLAFIDNLHHLCK-HLDFRE-DETDVKAVLGTLLNLMEDPD---------KDVRVAFSGNIKHILESLDSED----GFIKELFVLRMKEAYTHAQISRNNELKDTLILTTGDIGRAAKGDLVPFALLHLLHCLL--SK-SASVSGAAYTEIRALVAAKSVK-LQSFFSQYKKPICQFLVESLHSSQMTALPNTPCQNADVRKQDVAHQREMALNTLSEIANVFDFPDLNRFLTRTLQVLLPDLAAKA-SPAASALIRT-LGKQLNVNRR--------EILINNFKYIFSHLVCSCSKD-ELERA--LHYL----KNE-------TE-IELGSLLRQDFQGLHNELLLRIGEH-----YQQVFNGLSILA-------------S----FASSDDPYQGPR----D--IIS-PELMADYLQPK-------------------LLGILAFFNMQ------------------------L--LSSS--VGIEDKKMALNSLMSLMKLMGPKHVSSVRVKMMTTLRTGLRFKDDF-PELCCRAWDCFVRCLDHACLGSLLSHVIVALL--------PLIHIQPK----ETAAIFHYLIIENRDAVQD--F---L-HEI--YF-LPDH-------P---------------ELKKI------KAVLQEYR--KETSES-T-------DL----QTTL--------QLSMKAI-QHENVD-VRIHALTSL----------KETLYKN-QEKLIKYATDSE-T----------VEPIISQ----LVTVLLKGC--QD-A---N--SQARLL-------CGECLGELGAIDPGRLDFS-TTETQ-G-KDFTFVTGVEDSSFAYG-LLME-LTRAYLAYADNSRAQDSAAYAIQELLSI-------YDCREMET-------NGPGHQLW-RRFPEHVR-EILEPHLNTRYKSSQKST---DWSGVKKPIYLSKLGSNFAEWSASWA-----GYLITKVRHDLASKIFTCCSIMMKHDFKVTIYLLPHILVYVLLGCNQE----DQQEVYAEIMA--VLKHDDQHTINTQ---DIASDLCQLSTQTVFSMLDHLTQWARHKFQALKAEKCPHSKSNRNKVDSMVSTVDYEDYQSVTR---FLDLIPQDTLAVASFRSKAYTRAVMHFESFI-----T----EK----K----QNI---QEHLGFLQKLYAAMHEPDGVAGV-SAIRK-A-E-PSLKEQI--LEHESLGLLRDAT--AC-YDRAIQLEP---------D---------QII------HYHGVVKSMLGLGQLSTVITQV--NGVHA-N-RSEW-T-DELNTYRVEAA------WKLSQW-DLVENYLAADG-------K----STTWSVRLGQLLLSAK-----KR-----DI----TAFYDSLKLVRAEQIVPLSAASFERGSYQRGYEYIVRLHMLCELE--H-----SIKPLFQHS-----P----GDSSQED--SLNWV-ARLEMT----QNSYRAKEPILALRRAL--LSLNKRPDY-----------N-----------EMV----------GECWLQSARVARKAGHHQTAYNALLNA---GESR----------L----------------A---EL---YVERAKWLW---S-KG-DVH------------QAL----IVLQKGVELCFPENE-TP--PE---GKNMLIHGRAMLLVGRFMEET----A----N-------F---ES---NA----------IMKKYK----DVTA-------C-------LPE------------WEDGHFYLAKYYDKLMP--M------VTD------N---------------------K-----------------------------------------M-E---------KQGDLIRYIVLH-------FGRSLQY-GNQFIYQSMPRMLTL--------WLDYGTKA--YEWEKAGRSDRVQM-------RNDLGKINKVITEHTNYLAPYQFLTAFSQLISRICHSHDEVFVVLMEIIAKVF--LAYPQQAMWMMTAVSKSS--------Y-------P-MR-------VNRCKEILNKAIH-MK--K----SLEKFVGDAT------------RLTDKL-----------LELCNK----------P-------------V--------------------D----------G---------S------------------S---S----T-----------L--------------S-------------M----------------S----T----H-----------F----------------------------------K----------------------------------M----------------------------------L-------------KK----------L--------------VE-------EATFS------------------------------E------------------------------ILIPLQ--S--VMIPTLPSIL-------GTHANHASHEPF---------PGHW------A------YIAGFDDMVEI-L-A-SLQKPKKISLKGSD-----GKFYIMMCKP--K--DDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKG-VYMT------G------KE--L---RQC--M----LPK----S---AA---LS--EKLKVFREFLLPR-HP-PIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFN-----------CLFN---------KG-------ET-FE-V-PEIVPFRLTHNMVNGMGPMGTE-G-----LFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEW---SKP---VKGHSKA-------PL-----------------------------N---------------ET-------------GEVVN------------EKAKTHVLDI---EQRLQGVIKT-RNRV------TG------LPLS------IEGHVHYLIQEATDENLLCQMYLGWTPYM
1 PsiBlast_PDB 56.17100% -43 - C3 - - 5YZ0 - - ATR_HUMAN A:[2-2644] -GEHGLELASMIPALRELGSATPEEYNTVVQKPRQILCQFIDRILTDVNVVAVELVKKTDSQPTSVMLLDFIQHIMKSSPLMFVNVSGSHEAKGSC--IEFSNWIITRLLRIAATPSCHLLHKKICEVICSLLFLFKSKSPAI------FGVLTKELLQLFEDLVYLHRRNVMGHAV---------EWPVVMSRFLSQLDEHMGYLQSAPLQLMSMQNLEFIEVTLLMVLTRIIAIVFFRRQELLLWQIGCVLLEYG---SPKIKSLAISFLTELFQLGGLPAQPASTFFSSFLELLKHLVEMDTDQLKLYEEPLSKLIKTLFPFEAEAYRNIEPVYLNMLLEKLCVMFEDGVLMRLKSDLLKAALCHLLQYFLKFVPAGYESALQVRKV--------YVRNICKALLDVLGIEVDAEYLLGPLYAALKMESMEIIEEIQCQTQQENLSSNSDGISPKRRRLSSSLNPSKRAPKQTEEIKHVDMNQKSILWSALKQKAESLQISLEYSGLKNPVIEMLEGIAVVLQLTALCTVHCSH-QNMNCRTFKDCQHKSKKKPSVVITWMS--------LDFYTKVLKSCRSLLESVQKLDLEATIDKVVKIYDALIYMQVNSSFEDHILEDLCGMLSLPWIYSHSDDGCLKLT-TFAANLLTLSCRISDSYSPQAQSRCVFLLTLFPRRIFLEWRTAVYNWALQSSHEVIRASCVSGFFILLQQQNSCNRVPKILIDKVKD--DSDIVKKE------FASILGQLVCTLHGMFYLTSSLTEPFSEHGHVDLFCRNLKATSQHECSS-------SQ-LKASVCKPFL-FLLK----KKI--PSPVKLAFIDNLHHLCK-HLDFRE-DETDVKAVLGTLLNLMEDPD---------KDVRVAFSGNIKHILESLDSED----GFIKELFVLRMKEAYTHAQISRNNELKDTLILTTGDIGRAAKGDLVPFALLHLLHCLL--SK-SASVSGAAYTEIRALVAAKSVK-LQSFFSQYKKPICQFLVESLHSSQMTALPNTPCQNADVRKQDVAHQREMALNTLSEIANVFDFPDLNRFLTRTLQVLLPDLAAKA-SPAASALIRT-LGKQLNVNRR--------EILINNFKYIFSHLVCSCSKD-ELERA--LHYL----KNE-------TE-IELGSLL------------------------------------------------------ASSDDPYQGPR----D--IIS-PELMADYLQPK-------------------LLGILAFFNMQ------------------------L--LSSS--VGIEDKKMALNSLMSLMKLMGPKHVSSVRVKMMTTLRTGLRFKDDF-PELC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FVTGVEDSSFAYG-LLME-LTRAYLAYADNSRAQDSAAYAIQELLSI-------YDCREMET-------NGPGHQLW-RRFPEHVR-EILEPHLNTRYKSSQKST---DWSGVKKPIYLSKLGSNFAEWSASWA-----GYLITKVRHDLASKIFTCCSIMMKHDFKVTIYLLPHILVYVLLGCNQE----DQQEVYAEIMA--VLKHDD--------------DLCQLSTQTVFSMLDHLTQWARHKFQALKAEK-----------DSMVSTVDYEDYQSVTR---FLDLIPQDTLAVASFRSKAYTRAVMHFESFI-----T----EK----K----QNI---QEHLGFLQKLYAAMHEPDGVAGV-SAIRK-A-E-PSLKEQI--LEHESLGLLRDAT--AC-YDRAIQLEP---------D---------QII------HYHGVVKSMLGLGQLSTVITQV--NGVHA-N-RSEW-T-DELNTYRVEAA------WKLSQW-DLVENYLAADG-------K----STTWSVRLGQLLLSAK-----KR-----DI----TAFYDSLKLVRAEQIVPLSAASFERGSYQRGYEYIVRLHMLCELE--H-----SIKPLFQ-------------------------V-ARLEMT----QNSYRAKEPILALRRAL--LSLNKRPDY-----------N-----------EMV----------GECWLQSARVARKAGHHQTAYNALLNA---GESR----------L----------------A---EL---YVERAKWLW---S-KG-DVH------------QAL----IVLQKGVELCFPENE-TP--PE---GKNMLIHGRAMLLVGRFMEET----A----N-------F---ES---NA----------IMKKYK----DVTA-------C-------LPE------------WEDGHFYLAKYYDKLMP--M------VTD------N---------------------K-----------------------------------------M-E---------KQGDLIRYIVLH-------FGRSLQY-GNQFIYQSMPRMLTL--------WLDYGTKA--YEWEKAGRSDRVQM-------RNDLGKINKVITEHTNYLAPYQFLTAFSQLISRICHSHDEVFVVLMEIIAKVF--LAYPQQAMWMMTAVSKSS--------Y-------P-MR-------VNRCKEILNKAIH-MK--K----SLEKFVGDAT------------RLTDKL-----------LELCNK----------P-------------V--------------------D----------G---------------------------------------------------------------------------------------------------------H-----------F----------------------------------K----------------------------------M----------------------------------L-------------KK----------L--------------VE-------EATFS------------------------------E------------------------------ILIPLQ--S--VMIPTLPSIL-------GTHANHASHE--------------W------A------YIAGFDDMVEI-L-A-SLQKPKKISLKGSD-----GKFYIMMCKP--K--DDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKG-VYMT------G------KE--L---RQC--M----LPK----S---AA---LS--EKLKVFREFLLPR-HP-PIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFN-----------CLFN---------KG-------ET-FE-V-PEIVPFRLTHNMVNGMGPMGTE-G-----LFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEW---SK-------------------L-----------------------------N---------------ET-------------GEVVN------------EKAKTHVLDI---EQRLQGVIKT-RNRV------TG------LPLS------IEGHVHYLIQEATDENLLCQMYLGWTPYM
53 HHSearch 53.27100% -19 - C3 - - 5YZ0 - - ATR_HUMAN A:[2-2644] -GEHGLELASMIPALRELGSATPEEYNTVVQKPRQILCQFIDRILTDVNVVAVELVKKTDSQPTSVMLLDFIQHIMKSSPLMFVNVSGSHEAKGSC--IEFSNWIITRLLRIAATPSCHLLHKKICEVICSLLFLFKSKSPAI------FGVLTKELLQLFEDLVYLHRRNVMGHAV---------EWPVVMSRFLSQLDEHMGYLQSAPLQLMSMQNLEFIEVTLLMVLTRIIAIVFFRRQELLLWQIGCVLLEYG---SPKIKSLAISFLTELFQLGGLPAQPASTFFSSFLELLKHLVEMDTDQLKLYEEPLSKLIKTLFPFEAEAYRNIEPVYLNMLLEKLCVMFEDGVLMRLKSDLLKAALCHLLQYFLKFVPAGYESALQVRKV--------YVRNICKALLDVLGIEVDAEYLLGPLYAALKMESMEIIEEIQCQTQQENLSSNSDGISPKRRRLSSSLNPSKRAPKQTEEIKHVDMNQKSILWSALKQKAESLQISLEYSGLKNPVIEMLEGIAVVLQLTALCTVHCSH-QNMNCRTFKDCQHKSKKKPSVVITWMS--------LDFYTKVLKSCRSLLESVQKLDLEATIDKVVKIYDALIYMQVNSSFEDHILEDLCGMLSLPWIYSHSDDGCLKLT-TFAANLLTLSCRISDSYSPQAQSRCVFLLTLFPRRIFLEWRTAVYNWALQSSHEVIRASCVSGFFILLQQQNSCNRVPKILIDKVKD--DSDIVKKE------FASILGQLVCTLHGMFYLTSSLTEPFSEHGHVDLFCRNLKATSQHECSS-------SQ-LKASVCKPFL-FLLK----KKI--PSPVKLAFIDNLHHLCK-HLDFRE-DETDVKAVLGTLLNLMEDPD---------KDVRVAFSGNIKHILESLDSED----GFIKELFVLRMKEAYTHAQISRNNELKDTLILTTGDIGRAAKGDLVPFALLHLLHCLL--SK-SASVSGAAYTEIRALVAAKSVK-LQSFFSQYKKPICQFLVESLHSSQMTALPNTPCQNADVRKQDVAHQREMALNTLSEIANVFDFPDLNRFLTRTLQVLLPDLAAKA-SPAASALIRT-LGKQLNVNRR--------EILINNFKYIFSHLVCSCSKD-ELERA--LHYL----KNE-------TE-IELGSLL------------------------------------------------------ASSDDPYQGPR----D--IIS-PELMADYLQPK-------------------LLGILAFFNMQ------------------------L--LSSS--VGIEDKKMALNSLMSLMKLMGPKHVSSVRVKMMTTLRTGLRF-KDDFPELC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FVTGVEDSSFAYG-LLME-LTRAYLAYADNSRAQDSAAYAIQELLSI-------YDCREMET-------NGPGHQLW-RRFPEHVR-EILEPHLNTRYKSSQKST---DWSGVKKPIYLSKLGSNFAEWSASWA-----GYLITKVRHDLASKIFTCCSIMMKHDFKVTIYLLPHILVYVLLGCNQE----DQQEVYAEIMA--VLKHDD--------------DLCQLSTQTVFSMLDHLTQWARHKFQALKAEK-----------DSMVSTVDYEDYQSVTR---FLDLIPQDTLAVASFRSKAYTRAVMHFESFI-----T----EK----K----QNI---QEHLGFLQKLYAAMHEPDGVAGV-SAIRK-A-E-PSLKEQI--LEHESLGLLRDAT--AC-YDRAIQLEP---------D---------QII------HYHGVVKSMLGLGQLSTVITQV--NGVHA-N-RSEW-T-DELNTYRVEAA------WKLSQW-DLVENYLAADG-------K----STTWSVRLGQLLLSAK-----KR-----DI----TAFYDSLKLVRAEQIVPLSAASFERGSYQRGYEYIVRLHMLCELE--H-----SIKPLFQ-------------------------V-ARLEMT----QNSYRAKEPILALRRAL--LSLNKRPDY-----------N-----------EMV----------GECWLQSARVARKAGHHQTAYNALLNA---GESR----------L----------------A---EL---YVERAKWLW---S-KG-DVH------------QAL----IVLQKGVELCFPENE-TP--PE---GKNMLIHGRAMLLVGRFMEET----A----N-------F---ES---NA----------IMKKYK----DVTA-------C-------LPE------------WEDGHFYLAKYYDKLMP--M------VTD------N---------------------K-----------------------------------------M-E---------KQGDLIRYIVLH-------FGRSLQY-GNQFIYQSMPRMLTL--------WLDYGTKA--YEWEKAGRSDRVQM-------RNDLGKINKVITEHTNYLAPYQFLTAFSQLISRICHSHDEVFVVLMEIIAKVF--LAYPQQAMWMMTAVSKSS--------Y-------P-MR-------VNRCKEILNKAIH-MK--K----SLEKFVGDAT------------RLTDKL-----------LELCNK----------P-------------V--------------------D----------G---------------------------------------------------------------------------------------------------------H-----------F----------------------------------K----------------------------------M----------------------------------L-------------KK----------L--------------VE-------EATFS------------------------------E------------------------------ILIPLQ--S--VMIPTLPSIL-------GTHANHASHE--------------W------A------YIAGFDDMVEI-L-A-SLQKPKKISLKGSD-----GKFYIMMCKP--K--DDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKG-VYMT------G------KE--L---RQC--M----LPK----S---AA---LS--EKLKVFREFLLPR-HP-PIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFN-----------CLFN---------KG-------ET-FE-V-PEIVPFRLTHNMVNGMGPMGTE-G-----LFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEW---SK-------------------L-----------------------------N---------------ET-------------GEVVN------------EKAKTHVLDI---EQRLQGVIKT-RNRV------TG------LPLS------IEGHVHYLIQEATDENLLCQMYLGWTPYM
54 HHSearch 44.3722% -3 - C3 - - 5X6O - - ATR_YEAST C:[433-2367] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLILNEASVSIQTCFKT--NNITRLTS------WTVILGRLACLESEKF-------------MDNWYVCHLCDIEKTGNPFVRINPNRPEAAGKSEIFRILHSNFLSHPNIDEF--SESLLSGILFSLHRIFS-HFQPPK----QINKSFKLVQKCFMNSN---------RYLRLLSTRIIPLFNISDSHNS----E---DEHTATLIKFL---QSQKLPVVKENLVIAWTQLTLTTSNDVFDTLLLKLIDIFN--SD-DYSLRIMMTLQIKNMAKILKKT-PYQLLSPILPVLLRQLGKNLVERK---------------------------VGFQNLIELLGYS-SKTILDIFQRYIIPYAIIQY----KSDVLSE-IAKIMCDG-TSLINQMKVNLLKKNSRQIFAVALVKHGLF-SLDIL--ETLFLNRA--------------YITAYLPD--Y-TLAEITKLYKNSSDSENANMILCSLRFLI-------------T----NFEKDKR-HGSKYKNINWTDDQ-EQAFQKKLQDN-------------------ILGIFQVFSSD------------------------I--HDVEGRTTYYEKLRVINGISFLIIYAPKKSIISALAQISICLQTGLGL--KEVRYEAFRCWHLLVRHLNDEELSTVIDSLIAFIL--------QKWSEFNGKLRNIVYSILDTLIKEKSDLILKLKP---Y-TTL--A--LVGK-------P---------------ELGILARDGQFARMVNKIR--S---------------T----TDLI--------PIFANNL-KSSNKY-VINQNLDDI----------EVYLRRK-QTERSIDF-------------------DITL----VLGALLDTS--HK-FRNLD--KDLCEK-------CAKCISMIGVLDVTKHEFK-RTTYSEN-EVYDLNDSVQTIKFLIW-VINDILVPAFW-QSENPSKQLFVALVIQESLKY-------CGLSSESWDMNHKELYPNEAKLW-EKFNSVSK-TTIYPLLSSLYLAQSW-K---EYVPLKYPSNNF---EGYKIWVKRFT-----LDLLKTGTTE--NHPLHVFSSLIR--GSLSNFLLPYISLDIIIKA---PYADILNGIIIEFDS--IFTCNLEGM---N---NLQVDSLRMCYESIFRVFEYCKKWATEFKQNYSKLHGTFI---------IKDTKTTNMLLRIDE---FLRTTPSDLLAQRSLETDSFERSALYLEQCY-----R----QN----P----HDKNQNGQLLKNLQITYEEIGDIDSLDGV-LRTFA---T-GNLVSKI--EELQYSENWKLAQ--DC-FNVLGKF---------------------DPK------TTTRMLKSMYDHQLYSQIISNSSF-------------V-KEWYSIGLEAA------NLEGNV-QTLKNWVEQIESLRNIDDR----EVLLQYNIAKALIAIS-----NE-----DP----LRTQKYIHNSFRLIGTNFITSSKE-TTLLKKQNLLMKLHSLYDLS--F-----LSSAKDKF-------------EYKSN--TTILD-YRMERI----GADFVPNHYILSMRKSF--DQLKMNEQA-----------D-----------ADL----------GKTFFTLAQLARNNARLDIASESLMHC---LERR----------L----------------P---QA---ELEFAEILW---K-QG-END------------RAL----KIVQEIHEKYQENS-----------SVNARDRAAVLLKFTEWLDLS----N----N-------S---AS---EQ----------IIKQYQ----DIFQ-------I-------DSK------------WDKPYYSIGLYYSRLLE--R------K--------------------------------------------------------------------------------------GRFEYRAISY-------FLLAFEK-NTAKVRENLPKVITF--------WLDIAAAS--ISE---NRK--EML-------SKATEDICSHVEEALQH-PTYIWYFVLTQLLSRLL------AQIIMHILLSLA--VEYPSHILWYITALVNSN--------S-------S-KR-------VL---HILEKYRQ-HS--Q----NPHDLVSSAL-----------------L-----------TRVCLQ----------D-------------V--------------------K----------S---------I------------------TSR-S----G-----------K--------------S-------------L----------------E---------------------------------------------------------------------------------------------------------------------------------------------N-----------------------------------VAPS------------------------------A------------------------------MVVPVR--K--NLDIISPLES-------NS--------PF---------R-PV------V------SIIRFGSSYKV-F-S-SLKKPKQLNIIGSD-----GNIYGIMCK---K--EDVRQDNQYMQFATTMDFLLSKDIASRKRSLGINIYSVLSLREDCGILEMVPNVVTLRSILSTKYESLK-IKYS------L------KS--L---HDR--W----Q------H---TA---VD--GKLEFYME-QVDK-FP-PILYQWFLENFPDPINWFNARNTYARSYAVMAMVGHILGLGDRHCENILLDIQTGKVLHVDFD-----------CLFE---------KG-------K------------FRLTPNLLDALGIIGTE-G-----TFKKSSEVTLALMRKNEVALMNVIETIMYDRNMDH---SI----------------------------------------------------------------------------------------------------QKALKVL---RNKIRGIDPQ-----------DG------LVLS------VAGQTETLIQEATSEDNLSKMYIGWLPF-
63 HHSearch 42.2924% -3 - C3 - - 4JSV - - MTOR_HUMAN A:[10-1174] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ERAAKCRAYAKALHYKELEF-----Q----KG----P----T-----PAILESLISINNKLQQPEAAAGV-LEYAM-KHF-GELEIQA--TWYEKLHEWEDAL--VA-YDKKMDTNK---------D---------DPE------LMLGRMRCLEALGEWGQLHQQC--CEKWTLV-NDET-Q-AKMARMAAAAA------WGLGQW-DSMEEYTCMI--------P----RDTHDGAFYRAVLALH-----QD-----LF----SLAQQCIDKARDLLDAELTAMA--GESYSRAYGAMVSCHMLSELE--E-----VIQYKLVP------------ERREII--RQIWW-ERLQGC----QRIVEDWQKILMVRSLV--VS------------------P-----------HED----------MRTWLKYASLCGKSGRLALAHKTLVLL---LGVD----------PSRQLDHPLPTVH----P---QV---TYAYMKNMW---K-SA-RKI------------DAF----QHMQHFVQTMQQQAQ-HA--IA---TEDQQHKQELHKLMARCFLKL----G----EWQLNLQGINESTI---PK----------VLQYYS----AATE-------H-------DRS------------WYKAWHAWAVMNFEAVL--H------YKHQNQARDEK-----------------------------------------------------------------KKVTEDLSKTLLMYTVPAVQG-------FFRSISL-SRGNNLQDTLRVLTL--------WFDYGH----------------------------WPDVNEALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIG--RYHPQALIYPLTVASKST--------T-------T-AR-------HNAANKILKNMCE-H---------SNTLVQQAM------------MVSEEL-----------IRVAIL----------W-------------HEMWHEGL-------------EEASRLYFGERN---------V------------------K---G----M-----------F--------------EVLEP---------LHAMMERGPQTLKETSFNQAYGR----D-----------L----------------------------------MEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKQ----------------------------------L-------------PQLT--------S--------------LE-------LQYVS------------------------------P------------------------------KLLMCR-----DLELAVPGTY-------DP-------------------NQPI------I------RIQSIAPSLQV-I-T-SKQRPRKLTLMGSN-----GHEFVFLLKG--H--EDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKK-ILLN-------------IE--H---RIM--LRMAPDYD----H---LT---LM--QKVEVFEHAVNNT-AG-DDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFG-----------DCFE---------VA-------MTREK-F-PEKIPFRLTRMLTNAMEVTGLD-G-----NYRITCHTVMEVLREHKDSVMAVLEAFVYDPLLNW---RLM---DTNT--------------------------------------------------------------------------ALN------------KKAIQIINRV---RDKLTGRDFS-----------HD------DTLD------VPTQVELLIKQATSHENLCQCYIGWCPFW
37 Fugue 41.9921% 3 - C3 - - 5H64 - - MTOR_HUMAN A:[210-2549] -----------VAALRAC------------------------------------LILTTQREPKEMQKPQWYRHTFEEAEKGFDETLAKEKGMNRDDRIHGALLILNELVRISSMEGERL-------------------------------------------------REEMEEIT---------QQQLVHDKYCKDLMGF----GTKPRHITPFTSFQAVQPQQSNALVGLLG----YSSHQGLMGFGTSPSPAK---STLVESRCCRDLME----------------EKFDQVCQWVLKCRNSKNSLIQMTILNLLPRLAAFRPSAFTD--------------------------TQYLQDTMNHVLS----CVKVLYDLSRQIPQL--------K-KDIQDGLLKMLSLVL--------MHKPLRHPGMPKGLAHQLASPGLTTLPEASDVGSITLALRTLGSFEFEGHSLTQFVRHCADH-----FLNSEHKEIRMEAARTCSRLLTPSIHLISGHAHVVSQTAVQVVADVL-SKLLVVGITD--------PDPDIRYCV--------LASLDERFDAHLAQAENLQAL-----------------FVALNDQVFEIRELAICTVGRLS--------------------------------------------SMNPAFVMPFLRKMLIQILTELEHSGIGR---------IKEQS-----ARMLGHLVSN--APRLIRPY------MEPIL------------------------------------------------------------KALI-LKLK----DPD--PDP----------------------NPGVINNVLATIGELAQVSG---------LEMR----------------------KWVDELFIIIMDMLQDSSLLAKRQVALWTLGQLVASTGYVVEPYRKYPTLLEVLLNFL--K--TEQNQGTRREAIRVLGLLGALD-PYKH--------------------------------KVNIGMIDQSRDASAVSLSESKSSQDSSMLVNMGN------LPLDEFYP-AVSMVALMRI-FRDQSLSHHH--------TMVVQAITFIFKSLGLKCVQ-----------------------------------FLPQVMPTFLNVIRVCDGAI-----REFLFQQLGMLV-------------S----FVKSH---------------IR-P-----YMDEI-------------------VTLMREFWVMN------------------------T--SIQS--TIILLIEQIVVALGGEFKLYLPQLIPHMLRVFMHDNSPG------------------------------------------------RIVSIKLL----AAIQLFGANLDDYLHLLLP--P---I-VKL--FD-APEA-------P---------------LPSRK------AALETVDR--LTESLDFT-------DY----ASRI--------IHPIVRT-LDQSPE-LRSTAMDTL----------SSLVFQL-GKKY---------------------QIFIPM----VNKVLVRHR--IN-H---Q--RYDVLI-------CRIVKGYT--------------------------------------LMKK-LHVSTINLQKAWGAARR--VSKDDWLEW-------LRRLSLEL-------LKDSS----------------SPSLRSCWALAQA------YNPMARDLFNAAFVSCWSELNEDQQ-----DELIRSIELALTSQ-------------------------------DIA----EVTQTLLNLAE--FMEHSDKGPLPLR---D----------------------DNGIVLLGERAAKC-----------------------------------------------RAYAKALHYKE--L-----E----FQ----K----GPT---PAILESLISINNKLQQPEAAAGVLEYAMK-H-F-GELEIQA--TWYEKLHEWEDAL--VA-YDKKMDTNK---------D---------DPE------LMLGRMRCLEALGEWGQLHQQC--CEKWT-LVNDET-Q-AKMARMAAAAA------WGLGQW-DSMEEYTCMIP-------R----DT-HDGAFYRAVLALH-----QD-----LF----SLAQQCIDKARDLLDAELTAMAGE--SYSRAYGAMVSCHMLSELE--E-----VIQY---KL-----V----PERREII--RQIWW-ERLQGC----QRIVEDWQKILMVRSLV--VS------------------P-----------HED----------MRTWLKYASLCGKSGRLALAHKTLVLLLGVDPSRQLDHPLPTV-H----------------P---QV---TYAYMKNMWKSAR-KI-DAF------------QHMQHFVQTMQQQAQHAIATED-QQ--HK---QELHKLMARCFLKLGEWQLNL----Q----G-------I---NESTIPK----------VLQYYS----AATEHDRSWYKA-------WHA------------WAVMNFEAVLHYKHQNQ--A-------RD------E---------------------K-----------------------------------------K-K---------VTEDLSKTLLMYTVPAVQGFFRSISL-SRGNNLQDTLRVLTL--------WFDYG----------------------------HWPDVNEALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIG--RYHPQALIYPLTVASKST--------T-------T-AR-------HNAANKILKNMCE-HS--N----TLVQQAMMVS------------EELIRVAILWHEMWHEGLEEASR----------L-------------Y--------------------F----------G---------E------------------R---N----V-----------K--------------G-------------M----------------F----E----V-----------L----------------------------------E----------------------------------P----------------------------------L-------------HA----------M--------------MERGPQTLKETSFN------------------------------QAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVF--R--RISKQLPQLT-------SLELQYVSPKLLMCRDLELAVPGTYDPNQPII------RIQSIAPSLQV-I-T-SKQRPRKLTLMGSN-----GHEFVFLLKG--H--EDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKK-ILLN------I------EH--R---IML--R----MAP----D---YDHLTLM--QKVEVFEHAVNNT-AG-DDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFG-----------DCFE---------VA-------MT-RE-KFPEKIPFRLTRMLTNAMEVTGLD-G-----NYRITCHTVMEVLREHKDSVMAVLEAFVYDPLLNW-----------------------RL-----------------------------M---------------DT-------------NTALN------------KKAIQIINRV---RDKLTG-----RDFS------HD------DTLD------VPTQVELLIKQATSHENLCQCYIGWCPFW
66 HHSearch 40.9925% -3 - C3 - - 5WBY - - B:[13-1177] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ERAAKCRAYAKALHYKELEF-----Q----KG----P----T-----PAILESLISINNKLQQPEAAAGV-LEYAM-KHF-GELEIQA--TWYEKLHEWEDAL--VA-YDKKMDTNK---------D---------DPE------LMLGRMRCLEALGEWGQLHQQC--CEKWTLV-NDET-Q-AKMARMAAAAA------WGLGQW-DSMEEYTCMI--------P----RDTHDGAFYRAVLALH-----QD-----LF----SLAQQCIDKARDLLDAELTAMA--GESYSRAYGAMVSCHMLSELE--E-----VIQYKLVP------------ERREII--RQIWW-ERLQGC----QRIVEDWQKILMVRSLV--VS------------------P-----------HED----------MRTWLKYASLCGKSGRLALAHKTLVLL---LGVD----------PSRQLDHPLPTVH----P---QV---TYAYMKNMW---K-SA-RKI------------DAF----QHMQHFVQTMQQQAQ-HA--IA---TEDQQHKQELHKLMARCFLKL----G----EWQLNLQGINESTI---PK----------VLQYYS----AATE-------H-------DRS------------WYKAWHAWAVMNFEAVL--H------YKHQNQARDEK-----------------------------------------------------------------KKVTEDLSKTLLMYTVPAVQG-------FFRSISL-SRGNNLQDTLRVLTL--------WFDYGH----------------------------WPDVNEALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIG--RYHPQALIYPLTVASKST--------T-------T-AR-------HNAANKILKNMCE-H---------SNTLVQQAM------------MVSEEL-----------IRVAIL----------W-------------HEMWHEGLEEASRLYFGERNVK----------G---------M------------------F---E----VLEP--------LHAMMERGPQTLKETS-------------F----------------N----QAYGRD-----------L----------------------------------MEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKQ----------------------------------L-------------PQLT--------S--------------LE-------LQYVS------------------------------P------------------------------KLLMCR-----DLELAVPGTY-------DP---------N----------QPI------I------RIQSIAPSLQV-I-T-SKQRPRKLTLMGSN-----GHEFVFLLKG--H--EDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKK-ILLN-------------IE--H---RIM--LRMAPDYD----H---LT---LM--QKVEVFEHAVNNT-AG-DDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFG-----------DCFE---------VA-------MTREK-F-PEKIPFRLTRMLTNAMEVTGLD-G-----NYRITCHTVMEVLREHKDSVMAVLEAFVYDPLLNW---RLM---DTNT--------------------------------------------------------------------------ALN------------KKAIQIINRV---RDKLTGRDFS-----------HD------DTLD------VPTQVELLIKQATSHENLCQCYIGWCPFW
64 HHSearch 40.9724% -2 - C3 - - 4JSP - - MTOR_HUMAN A:[10-1174] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ERAAKCRAYAKALHYKELEF-----Q----KG----P----T-----PAILESLISINNKLQQPEAAAGV-LEYAM-KHF-GELEIQA--TWYEKLHEWEDAL--VA-YDKKMDTNK---------D---------DPE------LMLGRMRCLEALGEWGQLHQQC--CEKWTLV-NDET-Q-AKMARMAAAAA------WGLGQW-DSMEEYTCMI--------P----RDTHDGAFYRAVLALH-----QD-----LF----SLAQQCIDKARDLLDAELTAMA--GESYSRAYGAMVSCHMLSELE--E-----VIQYKLVP------------ERREII--RQIWW-ERLQGC----QRIVEDWQKILMVRSLV--VS------------------P-----------HED----------MRTWLKYASLCGKSGRLALAHKTLVLL---LGVD----------PSRQLDHPLPTVH----P---QV---TYAYMKNMW---K-SA-RKI------------DAF----QHMQHFVQTMQQQAQ-HA--IA---TEDQQHKQELHKLMARCFLKL----G----EWQLNLQGINESTI---PK----------VLQYYS----AATE-------H-------DRS------------WYKAWHAWAVMNFEAVL--H------YKHQNQARDEK-----------------------------------------------------------------KKVTEDLSKTLLMYTVPAVQG-------FFRSISL-SRGNNLQDTLRVLTL--------WFDYGH----------------------------WPDVNEALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIG--RYHPQALIYPLTVASKST--------T-------T-AR-------HNAANKILKNMCE-H---------SNTLVQQAM------------MVSEEL-----------IRVAIL----------W-------------HEMWHEGL-------------E----------EASRLYFGERN------------------VK--G----M-----------F--------------EVLEP---------LHAMMERGPQTLKETSFNQAYGR----D-----------L----------------------------------MEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKQ----------------------------------L-------------PQLT--------S--------------LE-------LQYVS------------------------------P------------------------------KLLMCR-----DLELAVPGTY-------DP---------N----------QPI------I------RIQSIAPSLQV-I-T-SKQRPRKLTLMGSN-----GHEFVFLLKG--H--EDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKK-ILLN-------------IE--H---RIM--LRMAPDYD----H---LT---LM--QKVEVFEHAVNNT-AG-DDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFG-----------DCFE---------VA-------MTREK-F-PEKIPFRLTRMLTNAMEVTGLD-G-----NYRITCHTVMEVLREHKDSVMAVLEAFVYDPLLNW---RLM---DTNT--------------------------------------------------------------------------ALN------------KKAIQIINRV---RDKLTGRDFS-----------HD------DTLD------VPTQVELLIKQATSHENLCQCYIGWCPFW
57 HHSearch 39.4918% 1 - C3 - - 6SL1 - - ? A:[1014-2944] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GDLYHYLV-KQSL----PNNSMSAAAQIRLASLLLHLLE-VKSEYA-SNLGLPSSQSTLLKILQDGP---------MKLKHYIGLEIPKLFGLYVLK-------THDDIFVDVLEHLPS--DPDVVEGLAFRLFVLAELACRW-PTLLRRSIYHTFEIPG----CVTHSALYAASCIKRIAQTLKLSGPQELFKLFAPQLLYTWLDND--SIQDIAY-----------------------------EIFGFSSLLDLLREAQTEAAAIMMMRG----QEQEVCQ-LAQSLGLTPE--------KLVQQSFTKIIAYSIAHDISIA---YVTGESRM----RKI-------LGKEEYLANIHLNFADIISTFFDIFDQE-----DP-IEKAFRRDERFAYAAETLEEIKK----LGHLP--------------TALPPNQQPMFRAKY-------------------LPREIVHLCSRTQYEPENIWTPALVVFVARKLLKTI--HP-A--LGPLHACSVLRKIRVLICLAGDHAIS--------------------------------------GYPLEMLLHSLRVFV--------VD-PECAD----DALGITQYLIKRGDEYLKR--TPSFL-AGYALSS-LADL-------RVFLSSQESQFKATKSKAQEF------HAWFSKYL--AAYDSP-EFKDEGQKQA----FRSI--------TENAAHIRASGNAE-KGTHESNLLLEILKDWGRENQLLNEPARDVALSMLCGVFNIPPSSRLDVIETDEDAIK----NGAVVWKSC--SS-Q---RLGGEYLAW-------AGRVLGRSFAASGEVPEDL-LRESQ----LQEYRRLSQGVGSSEE-GLLN-LIKSLT-ISGDCFTAGLAEAALRTIVSD-------AISDND-------------HDLL-SACQESLPEPLLIASNWDPYRTPLSD-----------EVFSA-RALENPNWSQHLA-----IRLALSAPK---IVTLRVLPPILSKVKGFAERAFPFVVHLVLAYQLDK-----QQSAKRELSE--SLQEWLNFT----------SEPAKENLKLLINTILYLRTQPLPGE---------------------------SSIADRAH---WLD-VNMASAAAAATRCGMYKVALLFAELAA-----E----ST----R-------------SDILLEIFENIDDPDAYYGL-SQD-------ASLSTVLARLEYENDGAKSLAFRGAQ-YDSHLRGRD---------LQ--------SRQ------DCNALIKALSSLGLAGLSNSLL--QSQ--------------SLDATFTTA------RKLEIW-NLPAP-----V-------N----SDSWAVTVYKAYQSMY-----QAQ----EL----DTVRSMVHDGLKNTVRHLSSGS---LNTSVLRQQLGALAALTELD--D-----ILNVRDQS-------------ELQCT--LATFE-KRSKWMM---SGRYADVSQILSCRETT--LSMWSQRHN-----------LRAAGLTSADARLVQ----------IRGMLLSSDIFRFHRARQETLNLSTAL---SDLIPSCESLGLSVD----------------A---AI---KMEAANALW---D-HG-EMI------------SSI----RMLQAIDKDSSLKK-----------QSVPLSRSDLLSKIGYQVSVA----R----L-------E---SP---DA----------IQKKYLE---PALK-------ELKGKIE-GRE------------AGQVFHQFAVFCDEQLQ--N------PDS------LEDLARLQNLKKGKDEEVAQLK-SHLAKAKQWQELDQQELRR----------------------VEQ---------TRSEFLKLCIEN-------YLLSLAA-SDEHDNDAL-RFMAL--------WLEKSE----------------------------EEVANEVVKKWINKVPTRKFALLMNQLSSRLQDHNTLFQKLLIDLVYRIC--VDHPYHGMYHIWTGARTR--------VNKDDEVAV-SR-------QRATDKIAKALSK-N---N----KVSSIWPAID------------QTSRVY-----------HALAMD----------R-------------D--------------------P----------T---------R------------------YKSGQ----K-----------V--------------P-------------I-------------------------------------------------------------------------K----------------------------------N----------------------------------S-------------PV--------------------------------------G------------------------------Q------------------------------NF--LS--T--MSNNPIPPPT-------LQIEVSANLD-----------YSHV------P------MIHKFAPEMAI-A-S-GVSAPKILTAIGTD-----GRKYKQLVKGG-N--DDLRQDAIMEQVFAAVSELLKLHRETRQRNLGIRTYKVLPLTSSSGLIEFVSNTIPLHEYLMPAHERYYPKDLK------G------SQ--C---RKE--I----ANA----QT--KN---TE--TRIAVYRR-VTER-FH-PVMRYFFMEYFPDPDEWFQKRTNYTRTTAAISMLGHVLGLGDRHGHNILLDHKTGEVVHIDLG-----------VAFE---------MG-------RV-LP-V-PELVPFRLTRDIVDGMGITKTE-G-----VFRRCCEFTLDALREEAASIQTILDSLRHDTLYQW---SIS---PVRMAKL-------QN-----------------------------------------------------------------------------SEADRAIEVV---KKKLS------------------------KTLS------VMATVNDLINQATSVSNLAVLYSGWAAYA
38 Fugue 39.2425% -3 - C3 - - 4JSP - - MTOR_HUMAN A:[10-1174] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ERAAKCRAYAKA-LHYKELE-----F----QK----G----PT----PAILESLISINNKLQQPEAAAGV-LEYAM-K-HFGELEIQA--TWYEKLHEWEDAL--VA-YDKKMDTNK---------D---------DPE------LMLGRMRCLEALGEWGQLHQQCC-EKWTL-V-NDET-Q-AKMARMAAAAA------WGLGQW-DSMEEYTCMIP-------R----DT-HDGAFYRAVLALH-----QD-----LF----SLAQQCIDKARDLLDAELTAMAGE--SYSRAYGAMVSCHMLSELE--E-----VIQ--YKLV-----P-----ERREII--RQIWW-ERLQGC----QRIVEDWQKILMVRSLV--VSPHED---------------------------------------MRTWLKYASLCGKSGRLALAHKTLVLLLGVDPSR----------QLDHPLPTVH-------P---QV---TYAYMKNMW---K-SA-RKI------------DAF----QHMQHFVQTMQQQAQ-HA--IA---TEDQQHKQELHKLMARCFLKL----G----E-------W---QL---NLQGINESTIPKVLQYYS----AATE-------HDRSWYKAWHA------------WAVMNFEAVLHYKHQNQ--ARDEKKKVTE------D---------------------L-----------------------------------------S-K---------TLLMYTVPAVQG-------FFRSISL-SRGNNLQDTLRVLTL--------WFDYGH----------------------------WPDVNEALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIG--RYHPQALIYPLTVASKST--------T-------T-AR-------HNAANKILKNMCE-HS--N----TLVQQAMMVS------------EELIRVAILWHEMWHEGLEEASR----------L-------------Y--------------------F----------G---------E------------------R---N----V-----------K--------------G-------------M----------------F----E----V-----------L----------------------------------E----------------------------------P----------------------------------L-------------HA----------M--------------MERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWD------------------------------LYYHVF--R--RISKQLPQLT-------SLELQYVSPKLLMCRDLELAVPGTY------DPNQPIIRIQSIAPSLQV-I-T-SKQRPRKLTLMGSN-----GHEFVFLLKG--H--EDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKK-ILLN------I------EH--R---IML--R----MAP----D---YDHLTLM--QKVEVFEHAVNNT-AG-DDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFG-----------DCFE---------VA-------MT-RE-KFPEKIPFRLTRMLTNAMEVTGLD-G-----NYRITCHTVMEVLREHKDSVMAVLEAFVYDPLLNW---R--------------------L-----------------------------M---------------DT-------------NTALN------------KKAIQIINRV---RDKLTGRDFS-HDD----------------TLD------VPTQVELLIKQATSHENLCQCYIGWCPFW
2 PsiBlast_PDB 35.2625% 1 - C3 - - 5X6O - - ATR_YEAST C:[876-2367] --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LQDN-------------------ILGIFQVFSSD------------------------IHDVEGR--TTYYEKLRVINGISFLIIYAPKKSIISALAQISICLQTGLGLKEVR-YE-AFRCWHLLVRHLNDEELSTVIDSLIAFILQKWSEFNGKLRNI--------VYSILDTLIKEKSDLILK--L---KPYTT--LA-LVGK-------P---------------ELGIL------ARDGQFARMVNKIRST-T-------DLIPIFANNL--------KSSNKYV-INQNLDDIEVYLRRKQ----------TERSIDF----------D--------------------------ITLVLGAL--LD-T---S--HKFRNLDKDLCEKCAKCISMIGVLDVTKHEFKRTTYSE-N-EVYDLNDSVQTIKFLIW-VIND-ILVPAFWQSENPSKQLFVALVIQESLKYCGLSSESWDMNHKEL-------YPNEAKLW-EKFNSVSK-TTIYPLLSSLY-LAQSWK---EYVPLKYP------SNNF-EGYKIWVKRFTLDLLKTGTTENHPLHVFS--SLIR---GSLSNFLLPYISLDIII---KA--------PYADILNGIIIEFDSIFTCNLEGMNNLQVDSLRMCYESIFRVFEYCKKWA------------TEFKQNYSKLHGTFIIKDTKTTNMLLRIDEFLRTTPSDLLAQRSLETDSFERSALYLEQCY-----RQNPHDK----N----QNG---Q-LLKNLQITYEEIGDIDSLDGV---LRTFA-T-GNLVSKI--EELQYSENWKLAQ--DC-FNVLGKF-----------D---------PKT------TTR-MLKSMYD-HQLYSQIISN--SSF-----------VKEWYSIGLEAANLEGNVQTLKNWVEQIESLRNIDD-------R----EVLLQYNIAKALIAIS-----NE-----DPLRTQKYIHNSFRLIGTNFI-----TSSKETTLLKKQNLLMKLHSLYDLSFLS-----SAKDKFEYK-------------SNTT--ILDY---RMERI----GADFVPNHYILSMRKSFDQLKMNEQADA-----------D-------------L----------GKTFFTLAQLARNNARLDIASESLMHC---LERR----------L----------------P---QA---ELEFAEILW---K-QG-END------------RAL----KIVQE-IHEKYQENS-SV---------NARDRAAVLLKFTEWLDLS----N----N-------S---AS---EQ----------IIKQYQ----DIFQ-------I-------DSK------------WDKPYYSIGLYYSRLLERK----------------G---------------------R-----------------------------------------F-E---------YRA--ISYFLLA-------FEKNTAK-----VRENLPKVITF--------WLDIAAAS--ISE---NRKEMLSK-------ATE--DICSHVEEALQH-PTYIWYFVLTQLLSRLL------AQIIMHILLSLA--VEYPSHILWYITALVNSN--------S-------S-KR-------VL---HILEKYRQ-HS--Q----NPHDLVSSAL-----------------L-----------TRVCLQ----------D-------------V--------------------K----------SIT-------S------------------R---S----G-----------K--------------S-------------L----------------E---------------------------------------------------------------------------------------------------------------------------------------------N----------V--------------AP-------SA----------------------------------------------------------------MVVPVR--K--NLDIISPLES-------NS-----PFRPV---------VS----------------IIRFGSSYKV-F-S-SLKKPKQLNIIGSD-----GNIYGIMCK---K--EDVRQDNQYMQFATTMDFLLSKDIASRKRSLGINIYSVLSLREDCGILEMVPNVVTLRSILSTKYESLK-IKYS------L------KS--L---HDR--W------Q----H---TA---VD--GKLEFYME-QVDK-FP-PILYQWFLENFPDPINWFNARNTYARSYAVMAMVGHILGLGDRHCENILLDIQTGKVLHVDFD-----------CLFE---------KG-------K------------FRLTPNLLDALGIIGTE-G-----TFKKSSEVTLALMRKNEVALMNVIETIMYDR------------------------------------------------------------------------------------------------------------------NM---DHSIQKALKVLRNKIRGIDPQDG------LVLS------VAGQTETLIQEATSEDNLSKMYIGWLPF-
39 Fugue 34.5919% -7 - C3 - - 5FVM - - ? A:[85-2469] ------------------------------------------------NVKAFDLIFTKLN--------------------QLERVAASYELKSCL--ISL-------------------------------------VSTEY------FQRFSNDINNKVFELIH-DSNEKLGGVL---------AVDTLIDELPNQTSRLANYLRV----LIDIEVMRAAATTLGKLAVLTSEFVEFEVKTCIEW------------------------LTQ--------------------EYRKHASLLIISSYPFVNSILDNIWRAL---RKLVIRTDAAVTLGKCLTS---SLTKKWVQRLFNGCIHGTLLVYRQLVSLELKDKYEEIYETTMK--------HRDNI--------------------------IIRKEIYAIIPVLAADPKLFTQKYLDATMIHYLTLLLSDKGPILVSIGDIAY---HIGPYLDAIVENLRDGLETKFKTRKEK--------------------------------DIFYCVSKLACAVRPLLAKYLN--------RGLLDASDHMQETLLVICEKISMEVTVNE--KLLNIICLVLSGEKFRPPGSPTPMKSLSSETARAYRDQSLLRKTGTLDAMILRKALRMLSDIKPK------YSLTEFIRRVIISYMEH------------------------------------------------------------------------------DNMQVRKLAALTSCDLFVKSLYALNVVSEVL-------SK-L------------LT----VAI--TDPVAEIRLEILKHL-----------------------DRLSQPD---------NTKLLFMALN-------------------DEVFAIQMEAMKICGRLAVIPSLRKTLIQLLTELKHSKM------------------------------TRKKEECASLLCT-LISSSSDVTKPYLEPVIEILLPSA---------------------VASTALKALGEISVVGG-EDMLPFLDELMPLIIDTFQDQSNSFKRGAALKA-LGQLAASSYP--------ELLGVLINI--------------LSQN--IRRE----TVR-------LI-GILGALDPYKHREVDVALLMQGEEY-----YPTVV--IGVLM-------------K----ILKDSIHHSTVI----Q--AIM-HIFQTMFLKQI-------------------IPGFILVMH-------------------------------PP--SLLELYFQQLSVLISIVKQHIRPHVTEIVDVISLTIISVIESLSRA-LE---------------GEFNPHLPTILSLFL--------DVLENKKV----VSVRILKSLVVFGPH-LEE--Y---V-HLV--LP-TIIK-------L---------------SSGNL------KKAAIITI--GRLSKN-N-------AL----EMSS--------RIVQALV-RVLNET-------EYV----------KATMNTL-SLLLLQLNIDFT-V----------FIPVINK----TLTIYDRLV--AK-L---L--NNEPL--------------PTKIIIDKDFDLP-NKEMD-D-VK---------------------------------VASKKLPVNQMVLKNA-------WDCSQQRT-------KEDWQEWI-RRLS---------------IESSSHAL---RACSGLAGIYYPLARELFNASFAQYQ-----EDLIQSLCAALSSTLLNLVEFMEHDDKPLPISI--STLGEYAQRCHAY----AKALHYKELEF--IEEPSTSTIESLI---TINNQLHQ--TDAAIGILKHAQQHHDLQLKETWYEKLQRWDDALNAYNKREAEVTIGKMRSLHA---LGEWDQLSELAADKWASSEVKRAIAPLAAGA-----A----WG----L----AQW---DRVEQYIEVMKPQSPDKAFFDAI-LCLHR-N-N-FEKAAEH--IFSARDLLVTEMS--AL-YNRA--------------Y---------GVV------VRTQMVAELEEIIQYKKLPQGS--ERRAM-I-RKTW-N-KRLLGCQ-----------NVDVW-QRVLKVRSLVI-------K----P--------------------KQ-----DM----KVWIKFANLCRKSGRLGLAQKTLNTLLEAPPPVVYAQLKYMWATG--S-----QKEALNHLI-----S----FTSRMAH--DLG-----LQHH----IEDYTKLLARCFLKQGE--WRVSLQPNW-----------R-----------LEN----------PDAILGSYLLATHFDKTW----------------------------------------------------YKAWHNWAL---A-NF-EVT------------SSL----TQRIKDDKV-PPTLN-AN--DN---FPPELVQRHVVPAIKGFFHSI----A----L-------S---QS---S------------LQDTL----RLLT-------L-------WFK------------FGGIPEAAQAMHEGFGL--I------KID------N---------------------W-----------------------------------------L-E---------VIPQLISRI---------------HQ-PNQTVSRSLLSLLAD--------LGKAHPQALVYPLTVAIKSDSVSR-------QRAALSIIDKMRMHSPKLVNQAELVS-DELIRVAVLWHELWYEGLEDASRQFF--GEHNTEKMFATLEPLHEM--------L-------K-RG-------PETLREISFQNSF-GR--D----LNDAYEWVLN------------YKRTK---------------------------------------------------------------D----------I---------N------------------N---L----N-----------Q--------------A-------------W----------------D----I----Y-----------Y----------------------------------N----------------------------------V----------------------------------F-------------RR----------I--------------SR-------KLPQL------------------------------Q------------------------------TLDLQH--V--SPKLSAAKDL-------ELAVPGTYHAGK---------PI--------V------RITHFEPVFTV-I-S-SKQRPRRVIIKGSD-----GKDYQYLLKS--H--EDIRQDNLVMQLFGLVNTLLQNDPESFQRHLNIQQYPAIPLSPKTGLLGWVPNSDTFHVLIREHREASK-IPLN------I------EH--R---IML--Q----MAP----D---YDNLTLL--QKVEVFTYALDNT-KG-QDLYKVLWLKSRSSESWLDRRTTYTRSLAVMSMVGYILGLGDRHPSNLMLDRITGKVVHIDFG-----------DCFE---------AA-------IL-RE-KYPEKVPFRLTRMLTYAMEVSGIE-G-----SFRITCENVMMVLRDNKESLMAILEAFAYDPLINW---GFD---LPTHAVMEQTGIDLPL-----------------------------A---------------NP-------------SELLRKGVISVEDAAKMELQQKAEVRN---ARATLVLKRI-ADKL------TGNDFPRCQELS------VPDQVDKLIQQATSVENLCQHYIGWCS--
60 HHSearch 33.3024% -4 - C3 - - 5FVM - - ? B:[1237-2469] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRTKEDWQ-EWI-----RRLSI----ESSSHALRACSGLAGIYYPLARELFNA----SFA------------QYQEDLIQ--SLCAALSS--------------------TLLNLVEFMEHDDK-----------------------------------------P-LPISISTLGEYAQRCHAYAKALHYKELEF-----I----EE----P----ST-----STIESLITINNQLHQTDAAIGI-LKHAQ-QHH-DL-QLKE--TWYEKLQRWDDAL--NA-YNKREA------------------------E------VTIGKMRSLHALGEWDQLSELA--ADKWA-S-S--EVK-RAIAPLAAGAA------WGLAQW-DRVEQYIEVM--------K----PQSPDKAFFDAILCLH-----RN-----NF----EKAAEHIFSARDLLVTEMSAL------YNRAYGVVVRTQMVAELE--E-----IIQYKKLPQ-----G----SERRAMI--RKTWN-KRLLGC----Q-NVDVWQRVLKVRSLV--IK------------------P-----------KQD----------MKVWIKFANLCRKSGRLGLAQKTLNTL---LE-------------AP--------------P---PV---VYAQLKYMW---A-TG-SQK------------EAL----NHLISFTSRMAHDLGL--QHHI---EDYTKLLARCFLKQGEWRVSL----QPNWRL-------E---NP---DA----------ILGSYL----LATH-------F-------DKT------------WYKAWHNWALANFEVTS--S------LTQRIKD--D---------------------KVPPTLNANDNFP-----------------------------P-E---------LVQRHVVPAIKG-------FFHSIAL-SQ-SSLQDTLRLLTL--------WFKFGG----------------------------IPEAAQAMHEGFGLIKIDNWLEVIPQLISRIHQPNQTVSRSLLSLLADLG--KAHPQALVYPLTVAIKSD--------S-------V-SR-------QRAALSIIDKMRM-H---------SPKLVNQAE------------LVSDEL-----------IRVAVL----------WHELWYEG------LEDASRQFF------------G----------EH--------N------------------T---E----KMFATLEPLHEMLKRGPETLREI----S-------------F----------------Q----N----S-----------FGRDL------------------------------N----------------------------------DAYEWVLNYKRTKDINNLNQAWDIYYNVFRRISRKL-------------PQLQ--------T--------------LD-------LQHVS------------------------------P------------------------------KLSAA---K--DLELAVPGTY-------HAG-------------------KPI------V------RITHFEPVFTV-I-S-SKQRPRRVIIKGSD-----GKDYQYLLKS--H--EDIRQDNLVMQLFGLVNTLLQNDPESFQRHLNIQQYPAIPLSPKTGLLGWVPNSDTFHVLIREHREASK-IPLN-------------IE--HRIMLQM--AP---DYD----N---LT---LL--QKVEVFTYALDNT-KG-QDLYKVLWLKSRSSESWLDRRTTYTRSLAVMSMVGYILGLGDRHPSNLMLDRITGKVVHIDFG-----------DCFE---------AA-------ILREK-Y-PEKVPFRLTRMLTYAMEVSGIE-G-----SFRITCENVMMVLRDNKESLMAILEAFAYDPLINW---GFD---LPTHAVM-------EQTGIDLPLANPSELLRKGVISVEDAAKMELQ---------------QK-------------AEVRN------------ARATLVLKRI---ADKLTGNDFP-----------RC------QELS------VPDQVDKLIQQATSVENLCQHYIGWCS--
65 HHSearch 33.1316% -17 - C3 - - 5Y81 - - ? B:[4-1115] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WYQSINILESIQSNTSID----NT----K----IIE----ANEDALLELYVNLQEEDMFYGL-WRRRA-K-Y-TET-NIG--LSYEQI--WDKAQ--QL-YEVAQVKAR----------------------QSEYALWEDNWIQCAEKL---DVLTELA--KHE-------------GFTDLLLECG------WRV-------RDALEQSVKSVM---D----VPTPRRQMFKTFLALQNFAESR------GD----QEVRKLCDEGIQLSLIKW-------RYTPAHKWLLHGFQQYMEFL--E-----ATQIYANLH-----TTT--AQEIKRI--LQAWR-DRLP--------DVNMWNDLVTWRQHA--FQVINNAYLPLIPALRG---Y-----------HEI----------AWVINRFAHVARKHNMPDVCISQLARI---YT---------------------------------------EAFLKLRE---Q-AK-CHY------------QNM----NELTTGLDVISN---------------GTVQKAEFFTLKGMFLSKL---------------------------E----------ANQAFA----TAVQ-------I-------DLN------------LAKAWAQWGFFNDRRLS--E------EP--------------------------------------------------------------------------------------SFASNAISC-------YLQAAGLYKNSKIRELLCRILWL--------ISIDDA----------------------------SGMLTNAFDSFRGEIPVWYWITFIPQLLTSLSHKEA---NMVRHILIRIA--KSYPQALHFQLRTTKEDF--------A-------VI--QP-----WEYLQELNNILKT-AY--PLLALSLESLVAQINDRFKSTTDEDLFRLINVL-----------LIDGTLNYNRL-----P------------------------------------------------------------------------------------PENTEKN----LV-------------KFSTTLLAPYIRPKF----------------N----A----D-----------FYETYI-----------------------------K----------------------------------R----------------------------------LRYWRRRLENKLDR----------------------------------------C------------------------------P------------------------------HLSNFH--HQKFEDIEIPGQY-------LLN------KDN---------NVHF------I------KIARFLPTVDF-V-RGTHSSYRRLMIRGHD-----GSVHSFAVQYPAV--RHSRREERMFQLYRLFNKSLSKNVETRRRSIQFNLPIAIPLSPQVRIMNDSVSFTTLHEIHNEFCKKKG-FDPD------DIQ----DF--M---ADK--L----NAAHDDAP---DM---TI--LKVEIFNS-IQTMFV--NVLKDHFTSLF--FEDFWLFRKQFASQYSSFVFMSYMMMINNRTPHKIHVDKTSGNVFTLEMLPSRFPYERVKPLLKN---------HDLDS----PI-FH-N-NEPVPFRLTPNIQSLIGDSALE-G-----IFAVNLFTISRALIEPDNELNTYLALFIRDEIISW---FSN---LHR---------------------------------------------------------------------------QLR------------EMVQTNVDLI---IRKVAQLGHL-----------NS------TPTV------TTQFILDCIGSAVSPRNLARTDVNFMPWF
58 HHSearch 33.1016% -4 - C3 - - 6JXC - - ATM_YEAST A:[928-2787] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NDILDWII-SRFE----DNSFTGVAPTVNLSMLLLSLLQNHDLSHGSIRGGKQRVFATFIKCLQKLD---------SSNIINIMNSISSYMAQVSYK-------NQSIIFYEIKSLFGP--PQQSIEKSAFYSLAMSMLSLVS-YPSLVFSLEDMMTYSG-----FNHTRAFIQQALNKITVAFRYQNLTELFEYCKFDLIMYWF-------------------------------------------------HEFLGRYFVEISAIYFSQG-F--NQKWILDMLHAITGNGDA--------YLVDNSYYLCIPLAFISGGVN---ELI--FDIL----PQISGKTTVKYH-KKYRLLMLKWI--IRFTDLGSLTEL-----RSTVEKLFPTSY-------------LSPYLFENSS--------------VSM-RYQYPLHIPLALGATLVQTQFAHEKNNTHEFKLLFLSVITD------------------------L--EK-T--STYIGKLRCARELKYLFVLYENVLVK--------------------------------------SSTLNFIIIRLSKFL--------ID-TQIHD----EVITIFSSLLNLADKNTFE--I---E-PSL--PNLFCKIFIYLRENKQLSPSFQQAI-----KLLEH------RDLIKIKT--WKYCLD---------AI----FGNIVQDDIYENTELLD-A-SDCGVD--D----VVL----------VSLLFSY-ARRPV-------------------ASKIGCSLSKAAAINILKHHVPKEYL---S--KNFKLW-------FAALSRRILQQE------------H-LKNFEMVFRHPEQPHMIYQRISTF--NKEAE-LYDSTEVFFISECILTYLVGY-------SIGNSESE------------FCFRDNIMNENK-DKVAPLDKDVLNAIYPLANNFGMESFICDTYL-SVNEPYNCWLSKFA-----RSLIHQISF--NIPPIVCLYPLCKGSTAFCELVLTDLFFLSTTYDP--------KSCLNWSNR--IFTQIAMLL---------HVKDSEIKLKMLFNVIKMIRMGSRCKER-----------------------------NCLRI---YS-SLDLQEICQISLKIKEFKFGYLLFEEMN-----M----PN----I----R-----EMNINTLQKIYECINDGDFLAGL-PVP-------HSIEGVLNSINR-IDSDTWKRF--LF-NNADFDANY---------TTS-------LEE------EKESLIKATEDSGFYGLTSL-L--ESRLS---G---------SSDVYKWN------LELGDW-KLLTPKV----------------VDSKAKGLYYAIKNLP-----QD-----V-----GFAEKSLEKSLLTIFDSR-----Q--HFISQTEWMDTLNAIIEFI--K-----IAAIPQDVT-----------SFPQTLMSIMKADKERL--N----TIDFYDHKTTLKSRHTL--MNVLSRNSL-----------D-----------ENVKCSKYLRLGSIIQLANYVQLAIANGAPQDALRNATLM---SKTV----------KNIAKLYDDPSVVSQIEK---LA---SFTSANALW---E-SR-EYK------------APV----MIMRDLLAQNEKNIS-ESILYDDFKLLINVPMDQIKARLVKWSSES----R----L-------E---PA---AA----------IYEKIIVNWDINVE-------D-------HES------------CSDVFYTLGSFLDEQAQ--K------LRS------NGEIE-----------------DREHRSYTGKSTLKALELIYKAKRHYNRVLLQYNRDSEVLKALLL---------QKEKFLWHALHF-------YLNTLVF-SNRYDNDIIDKFCGL--------WFENDD----------------------------NSKINQLLYKEIGTIPSWKFLPWVNQIASKISMEENEFQKPLQLTMKRLL--YKLPYDSLYSVMSILLYEKQSNKDTNI-------S-QK-------IQAVKKILLELQG-YDRGA----FAKKYLLPVQ------------EFCEMS-----------VELANL----------K-------------F--------------------V----------Q---------N------------------T---K----T-----------L--------------R-------------L----------------A----N----L----------------------------------------------K----------------------------------I----------------------------------G-------------QY----------W--------------LK---------------------------------------------------------------------------------Q--LNMEKLPLPT-------SNFTVKSSADG----------RKAR------P------YIVSVNETVGI-TTT-GLSLPKIVTFNISD-----GTTQKALMKGS-N--DDLRQDAIMEQVFQQVNKVLQNDKVLRNLDLGIRTYKVVPLGPKAGIIEFVANSTSLHQILSKLHTNDK-IT--------F------DQ--A---RKG--M----KAV----QT--KS---NE--ERLKAYLK-ITNE-IK-PQLRNFFFDSFPDPLDWFEAKKTYTKGVAASSIVGYILGLGDRHLNNILLDCSTGEPIHIDLG-----------IAFD---------QG-------KL-LP-I-PELVPFRLTRDIVDGFGVTGVD-G-----LFRRSCERVYAVLRKDYVKVMCVLNILKWDPLYSW---VMS---PVKKYEH-------LF-----------------------------E--------------------------------NEN------------QESYRALKGV---EEKLMG-----------------------NGLS------VESSVQDLIQQATDPSNLSVIYMGWSPFY
67 HHSearch 29.5815% -8 - C3 - - 5OJS - - TRA1_YEAST T:[2561-3767] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSDFIDSLIEIFYQDPKAIHRAWVTLFPQVYKSIPKN----EKYGFVRSIIT--LLSKPYHTR---------QISSRTNVINMLLDSISKIE------------------------------------S----------LELPPHLVKYLAISYNAWYQSINILESIQ-----S----NT----SIDNTKII---EANEDALLELYVNLQEEDMFYGL-WRRRA-K-Y-TETNIG---LSYEQIGLWDKAQ--QL-YEVAQVKAR---------SGALPYSQSEYAL------WEDNWIQCAEKLQHWDVLTELA--KHEG-------------FTDLLLECG------WRVADW-NSDRDALEQSVKSVM---D----VPTPRRQMFKTFLALQ-----NFAESRKGD----QEVRKLCDEGIQLSLIKWVSLP--IRYTPAHKWLLHGFQQYMEFL--E-----ATQIYANLHTTTVQNLDSKAQEIKRI--LQAWR-DRLPNT----WDDVNMWNDLVTWRQHA--FQVINNAYLPLIPALQAYRGY-----------HEI----------AWVINRFAHVARKHNMPDVCISQLARI---YTLP----------N----------------IEIQEAFLKLREQAKCHY---QNMN-ELT------------TGL----DVISNTNLVYFG----------------TVQKAEFFTLKGMFLSKL----R----A------------Y---EE----------ANQAFA----TAVQ-------I-------DLN------------LAKAWAQWGFFNDRRLS--E------EPN-----------------------------------------------------------------------------------NISFASNAISC-------YLQAAGLYKNSKIRELLCRILWL--------ISIDDA----------------------------SGMLTNAFDSFRGEIPVWYWITFIPQLLTSLSHKEAN---MVRHILIRIA--KSYPQALHFQLRTTKEDF--------AVIQ--------RQP----WEYLQELNNILKT-AY--PLLALSLESLVAQINDRFKSTTDEDLFRLINVL-----------LIDGTLNYNRLPFPRKNPK-----------L--------------------P----------E---------N------------------T---EKNLVK-----------FSTTLLAP-------Y-------------I----------------RPKFNA----DFIDNKPDYETYI----------------------------------K----------------------------------R----------------------------------L-------------RY----------WRRRLENKLDRASKKEN-------LEVLC------------------------------P------------------------------HLSNFHHQK--FEDIEIPGQY-------LLNK------DN---------NVHF------I------KIARFLPTVDF-V-RGTHSSYRRLMIRGHD-----GSVHSFAVQY--PAVRHSRREERMFQLYRLFNKSLSKNVETRRRSIQFNLPIAIPLSPQVRIMNDSVSFTTLHEIHNEFCKKKG-FDPD------DIQDFMADK--L---NAA--H----DDALPA-P---DM---TI--LKVEIFNSIQTMF-VPSNVLKDHFTSLFTQFEDFWLFRKQFASQYSSFVFMSYMMMINNRTPHKIHVDKTSGNVFTLEML-----------PS------------DLSLPPDSPI-FH-N-NEPVPFRLTPNIQSLIGDSALE-G-----IFAVNLFTISRALIEPDNELNTYLALFIRDEIISW---FSN---LHRPII--------------------------------------------------------E-------------NPQLR------------EMVQTNVDLI---IRKVAQLGHL-----------NS------TPTV------TTQFILDCIGSAVSPRNLARTDVNFMPWF
69 HHSearch 27.7215% 7 - C3 - - 5OEJ - - ? B:[2534-3825] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LTAGDILNPLIDI---SAETIHNAWVVVFPVA-----SR----YELEFTRALVK--LLFKDYHI---------------PNVIKSLLDGVGKC----------------------------------------------------PHLVKYLGSNYNAWYGAIKLLEELS-----E----GQGIDNQ----KIS---DANQDALLEVYMSLQEDDMFYGT-WRRRA-K-Y-FETNAA---LSYEQIGIWDKAL--QL-YEAAQIKARSGVFPFGESE---------YSL------WEDHWIYCAEKLQHWEILTELA--KHE-------------GFTDLLLECG------WRGADW-IADREPLEQSV-------KTVMDIPTPRRQIFQTFLALQGFSQQKD-----TL----QDVSRLCDEGIQLTLRKWNALP--QRVTRAHIGLLHTFQQYVELM--E-----ASQVYSSLVTTNAQNLDVKSQELKRV--LQAWR-ERLPN-------DINIWNDLVTWRQHV--FGVINRV--SYAYRG-----Y-----------HEM----------AWVINRFAHVARK-----VCINQLTK------------------------------------AF-LK---LREQAKC---------SELN------------TGL----DVIS-------A----------------TQQKAEFFTLKGMFLAKL----N----A------------K---DE----------ANQAFA----TAVQ-------I-------DLN------------LPKAWAEWGFFNDRRFK--E------NPE-----------------------------------------------------------------------------------EIFHAKNAISC-------YLQAAGLYKDGKTRKLLCRILWL--------ISLDDA----------------------------AGSLAKTFEDHHGESPVWYWITFVPQLLTSLSHKEA---KIVRHILIQIA--KSYPQSLHFQLRTTKEDY--------Q-----------TTDSRQPWQDVEEIMGILKT-AY--PLLALSLESLVDQLNQRFKCNADEDAYRLVIVL-----------YNDGVQ----------QMNRPAATEASISRF--------------------ADSVLP-----K---------NI-----------------R---EVFEQD-----------IIACNP---------N-------------L----------------E----T----Y-----------I----------------------------------S----------------------------------K----------------------------------L-------------RKWRDCLEEKLGK--------------AD-------LERVS------------------------------L------------------------------HLSLFHHQK--FEDIEIPGQY-------LLH------KDN---------NNHF------I------KIERFLPTLDLVR-G-SNGCYKRMTIRGND-----GSLHPFAVQFPAA--RHCRREERIFQLFRIFDDALSRKVQSRRRNISLTLPIAVPLSPHIRILNDDKRYTTLMGIYEEFCRRKG-QSRDEPFAYTI------QK--L---RAA--F----DPR----LPKPDI---VS--VRAEVLASIQSTL-VPSTLLKDYYTEKFSNYENYWLFRKQFTAQYASFIFMTYIMCINSRQPQKIHINEGSGNIWT---S-----------TAYNNSTLDPAVKAGA------PI-FY-N-TESVPFRLTPNIQKFIGEAGLE-G-----ILSVYILVIANSLSDSEFDMEQYLSLFVRDEVISW---FAQ---QHRASAQ---------------------------------------------------------------------TNQLR------------EIVRVNVELL---TKRVLQLNHI-----------PN------SQNV------ATQFVLNLISQAVNPRNLAYTDSAWMAYL
59 HHSearch 27.5524% -5 - C3 - - 6EMK - - TOR2_YEAST A:[1234-2474] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QKTKEDWQ-EWI-----RRLSIQLLKESPSACLRSCSSLVSVYYPLARELFNAS----FSSCWVE----LQTSYQED-------------------------------------LVEFMEHDDK-----------------------------------------P-LPIPIHTLGKYAQKCHAFAKALHYKEVEF-----L----EE----P----KN-----STIEALISINNQLHQTDSAIGI-LKHAQ-QHN-ELQLK-E--TWYEKLQRWEDAL--AA-YNEKEAAGE---------D---------SVE------VMMGKLRSLYALGEWEELSKLA--SEKWG-TAKPEV-K-KAMAPLAAGAA------WGLEQW-DEIAQYTSVM--------K----SQSPDKEFYDAILCLH-----RN-----NF----KKAEVHIFNARDLLVTELSAL--VNESYNRAYNVVVRAQIIAELE--E-----IIKYKKLPQ-----N----SDKRLTM--RETWN-TRLLGC----QKNIDVWQRILRVRSLV--IK------------------P-----------KED----------AQVRIKFANLCRKSGRMALAKKVLNTL---LEET----------DDPDHPNTAKAS-----P---PV---VYAQLKYLW---A-TG-LQD------------EAL----KQLINFTSRMAHDL-------V---EDYTKLLARCFLKQGEWRVCLQPKWR----L-------S---NP---DS----------ILGSYL----LATH-------F-------DNT------------WYKAWHNWALANFEVI------------------------------------------S----------------------------------------S-N---------LIHRHVIPAIKG-------FFHSISL-SESSSLQDALRLLTL--------WFTFGG----------------------------IPEATQAMHEGFNLIQIGTWLEVLPQLISRIHQPNQIVSRSLLSLLSDLG--KAHPQALVYPLMVAIKSE--------S-------L-SR-------QKAALSIIEKMRI-H---------SPVLVDQAE------------LVSHEL-----------IRMAVL----------W-------------HEQWYEGLDDASRQFF-----G----------EH--------NTEKMFAALEPLYEMLKRGP---E----TLRE--------I--------------S-------------F----------------Q----N----S-----------FGRDLNDAYEWLMNYKKSKDVSNLNQAWDIYYNVFR----------------------------------K----------------------------------IGKQL---------PQLQ--------T--------------LE-------LQHVS------------------------------P------------------------------KLLSAH-----DLELAVPGTR-------ASGG------------------KPI------V------KISKFEPVFSV-I-S-SKQRPRKFCIKGSD-----GKDYKYVLKG--H--EDIRQDSLVMQLFGLVNTLLQNDAECFRRHLDIQQYPAIPLSPKSGLLGWVPNSDTFHVLIREHREAKK-IPLN------I------EHWVM---LQM--AP---DYD----N---LT---LL--QKVEVFTYALNNT-EG-QDLYKVLWLKSRSSETWLERRTTYTRSLAVMSMTGYILGLGDRHPSNLMLDRITGKVIHIDFG-----------DCFE---------AA-------ILREK-F-PEKVPFRLTRMLTYAMEVSGIE-G-----SFRITCENVMKVLRDNKGSLMAILEAFAFDPLINW---GFD---LPTKKIEE------ET-----------------------------GIQLPVMNANELLSNGAITEEEVQRVENEHKNAIRN------------ARAMLVLKRI---TDKLTGNDIR-----------RF------NDLD------VPEQVDKLIQQATSVENLCQHYIGWCPFW
40 Fugue 26.1312% -6 - C3 - - 1E8X - - PK3CG_PIG A:[1-951] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AA--SE-ETLAFQRQL---------N---------ALI------GYDVTDVSNVHDDELEFTRRRL--VTPRM-A-EVAG-R-DPKLYAMHPWV------TSKPLP-EYLLKKITNNC-------V----FIVIHRSTTSQTIKVS-----AD-----DT----PGTILQSFFTKMANERDFVLRVCGRDEYLVGETPIKNFQWVRQCL--KNGEEIHLVLDTPPD-----P----ALDEVRK--ECDRK-FRVKIRGIDIPVLPRTADLTVFVEANI--QYGQQVLCQ-----------R-----------RTS----------PKPFTEEVLW----NVWLEFSIKIKDL---PKGA----------L----------------L---NL---QIYCQLLYY---V-NL-LLI------------DHR----FLLRHGEYVLHMWQL-SG--FN---ADKLTSATNPDKENSMSISIL----L----D-------N---HP---IA----------LEMPNQ----LRKQ-------L-------EAI------------IATDPLNPLTAEDKELL--W------HFR------Y---------------------E-----------------------------------------S-L---------KDPKAYPKLF-----------SSVKW-GQQEIVAKTYQLLAK--------REVWDQSA--LD--VGLTMQLLDC-------NFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQS----------------R-HY-------QQRFAVILEAYLRGCG--T----AMLHDFTQQV------------QVIDML-----------QKVTID----------I-------------K--------------------S----------L---------S------------------A---E-------------------------------K-------------Y----------------D----V----S-----------S----------------------------------Q----------------------------------V----------------------------------I-------------SQ----------L--------------KQ-------KLENL------------------------------Q------------------------------NLNLPQ--S--FRVPYDPGLK-------AGALV--------------------------------------IEKCKV-M-A-SKKKPLWLEFKCADPTALSNETIGIIFKH--G--DDLRQDMLILQILRIMESIWET----ESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTG-------------------------------------------------------------------AF-KD-EVLSHWLKEKCPIEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMISE-TGNLFHIDFG-------------------------------------------HVPFVLTPDFLFVMGTSGKK-TSLHFQKFQDVCVKAYLALRHHTNLLIILFSMMLMTGMPQL---TSKEDIEYIRDAL-------TV-----------------------------G---------------KS-------------EEDAK------------KYFLDQIEVC---RDKGWTVQFN-WFLH------LV------L--------------------------------------
50 Fugue 25.5213% -34 - C4 - - 3W3W - - IMB3_YEAST A:[3-1077] ----------------------------------------------------------ALPEEVNRTLLQIVQAFASDNQIRSVAEKALSEEW-----ITENN--IEYLLTFLAEQAAFSQDTTVAALSAVLFRKLALKAPITHIRKEVLAQIRSSLLKGFLSERADSIRHKLSDAIAECVQDDLPAWPELLQALIESLKSGNPNFRESSFRILTTVPYLITAVDINSILPIFQSGFTDASDNVKIAAVTAFVGYFKQLPKSEWSKLGILLPSLLNSLPRFLDDGKDDALASVFESLIELVELA---PKLFKDMFDQIIQFTDMVIKN--KDLEPPARTTALELLTVFSENAPQMCKSNQNYGQTLVMVTLIMMTEVSIDDDDAAEWIESDDTDDEEEVTYDHARQALDRVALKLGGEYLAAPLFQYLQQMITS---------------------TEWRERFAAMMALSSAAEGCADVL----IGEIPKILDMVIPLIND-----PHPRVQYGCCNVLGQISTDFSPFIQRTAHDRILPALISKLTSECTSRVQTHAAAALVNFSEFASKDILEPYLDSLLTNLLVLLQSNKLYVQEQALTTIAFIAEAA-----KNKFIKYYDTLMPLLLNVLKVNSVLKGKCMECA-TLIGFAV--GKEKFHEHSQELISILVALQNSDALRSYLEQSWSRICRILGDDFVPLLPIVIPPLLITAKATQDVGLIEEEEAANFQQYPDWDVVQVQGKHIAIHTSVLDDKVSAMELLQSYATLLRGQFAVYVKEVMEEIALPSLDFYLHDG-------VR-AAGATLIPIL-LSCL----LA---AEELVLLWHKASSKLIG-GLMSEP-MPEITQVYHNSLVNGIKVMGDNCLSEDQLAAFTKGVSANLTDTYERMQDRDEYNEDFTDEDLLDEINKSIAAVLKTTNGHYLKNLENIWPMINTFLLEPILVIFALVVIGDLIQYEQ-TASMKNAFIPKVTECLISPDAR-IRQAASYIIGVCAQY---APSTYADVCIPTLDTLVQIVDGSKLEENRSSTENASAAIAKILYAYNSNIPDTYTANWFKTLPTITD-KEAASFNYQF-LSQVCAQSNI--------SAVVDSVIQALNERSLT-VIS-SVKKL--LGFL----PSS-------DA-MAIFNRYPADIMEKVHKWF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47 Fugue 24.6015% -9 - C3 - - 4TUU - - PK3CA_HUMAN A:[107-1046] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N----RE----E----KIL---NREIGFAIGMPVCEFDMVKDPEV-QDFRR-N-I-LNVCKEA--VDLRDLNSPHSRA--MYVYPPNVESSP---------E---------LPK------HIY----NKLDKGQIIVVIWVI--VSPNN-D-KQKY-T-LKINHDCVPEQ------VIAEAI-RKKTRSMLYQG-------K----YILKVCGCDEYFLEKY----------------------------------PLSQYKYIRSCIMLGRMPNLMLMAKESLY--S-----QLPMDCFTM-----P----SYSRKSLW-VINSA-LRIKIL----CATYVNVNDKIYVRTGI--YH-GGEPLC-----------D-----------NVN----------TQRVPCSNPRWNEWLNYDIYIPDLPRA---ARLC----------L----------------S---IC---SVKEEHCPL---A-WG-NINLFDYTDTLVSGKMAL----NLWPVPHGLEDLLNP-IG--VT---GSNPNKETPCLELEFDWFSSV----V----K-------F---PD---MS----------VIEEHA----NWSV-------S-------REAGFSYSHAGLSNRLARDNELRENDKEQLKA--I------STR------D---------------------P-----------------------------------------L-S---------EITEQEKDFLWS-------HRHYCVT-----IPEILPKLLLSVKWNSRDEVAQMYCLV--KDWPPIKPEQAMELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTNQ--RIGHFFFWHLKSEMHNKT--------V-------S-QR-------FGLLLESYCRACG-M---------YLKHLNRQV------------EAMEKL-----------INLTDI----------L-------------K--------------------Q----------E---------K------------------K---D----E--------------------------------------------------------------T----Q-----------K----------------------------------V----------------------------------Q----------------------------------M-------------KF----------L--------------VE-------QMRRP------------------------------D------------------------------FMDALQ--G--FLSPLNPAHQLGNLRLEECRIMSSAKRPL---------WLNW------E---------NPDIMSEL-L-F---------------------QNNEIIFKN--G--DDLRQDMLTLQIIRIMENIWQN----QGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCKGF--------------------------------------------------------------------------NS-HTLHQWLKDKNKGE-IYDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKD-DGQLFHIDFG-----------HFLD---------R-------------------VPFVLTQDFLIVISTKTREFE-----RFQEMCYKAYLAIRQHANLFINLFSMMLGSGM-------PE---LQSFDDI-------AY-----------------------------I---------------RK-------------TLALD------------KTEQEALEYF---MKQMNDA-------------------------------------------------------------
18 PsiBlast_PDB 24.1532% -45 - C3 - - 3JBZ 2.5 - A:[776-1164] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LQV-I-T-SKQRPRKLTLMGSN-----GHEFVFLLKG--H--EDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALI-RDYREKK-KILL------N------IE--H---RIMLRM----APD----Y---DH---LTLMQKVEVFEHAVNNT-AG-DDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFG-----------DCFE---------VA-------MT-REKF-PEKIPFRLTRMLTNAMEVTGLD-G-----NYRITCHTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTN---T------------------------------------------------------------------------------------------------------ALNKKAIQIINRV-RDKL------TG------RDFSHDDTLDVPTQVELLIKQATSHENLCQCYIGWCPF-