@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Screening
Virtual Screening Score
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : AURKA_HUMAN: (2020-09-04 )
MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
Atome Classification :
(374 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.---.---......160....-...170-..-......180.--......190.......200.......210.......220...-..-..230.......240.......-250.......260.....---..----270.....---.--.-280.-.-.--.---.---..--.-.----290.......300...-..-.-.310.......320.......330---........340-..---..----...--.----350-........360.......370.-----.-----...-....380.-......---390.......400.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(pKd)
(pKd)
(Uniprot)
MDRSKENCISGPVKATAPVGGP
K
R
V
L
V
T
QQFPCQNPLPVNSGQ
A
Q
R
V
LCPSNSSQRV
P
L
Q
A
Q
K
L
V
S
SHKPV
Q
N
Q
K
Q
K
Q
LQATSVPHPVSRPLNNTQKSKQPLPSAPENN
P
E
E
E
L
A
S
KQK
N
E
E
S
K
K
R
QWALEDFEIGRPLGKGKFG
N
V
Y
L
A
-RE---K---QS
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-K-A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
HLRHP
N
I
L
R
L
Y
G
Y
FHD
A
T
R
V
Y
L
I
L
EYAP
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
HRDIKPE
N
L
L
LGSA---G
E
----
L
K
I
A
DF
G
W
---
S
--V-H--A-P-S--S---R---R
T
--
T
-
L
----CGTLDYL
P
P
E
M
I
EGRM-HD-E-KV
D
L
W
S
L
G
V
L
C
Y
E
F
LVGKPPFEA----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----FT
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
KHNPSQ--
R
-----
P
-----
M
L
R
-
E
V
L
EHPWI-TANSSK---PSNCQNKESASKQS
146
Blastp_CBE
89.77
99%
-109
- C1 -
-
5DNR
6.4
-
AURKA_HUMAN
A:
[7-271]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
T
--
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
-------------
67
Blastp_CBE
89.68
99%
-110
- C1 -
-
3UOD
7.7
-
AURKA_HUMAN
A:
[2-267]
---------------------------------------------------------------------------------------------------------------------------
K
K
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
D
--
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
-----------------
147
Blastp_CBE
89.36
99%
-109
- C1 -
-
5DN3
6.4
-
AURKA_HUMAN
A:
[6-270]
----------------------------------------------------------------------------------------------------------------------------
K
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
T
--
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
-----------------
70
Blastp_CBE
89.18
99%
-109
- C1 -
-
3UO5
7.4
-
AURKA_HUMAN
A:
[2-268]
---------------------------------------------------------------------------------------------------------------------------
K
K
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
D
--
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
-------------
58
Blastp_CBE
89.04
99%
-110
- C1 -
-
3UP2
8.1
-
AURKA_HUMAN
A:
[2-267]
---------------------------------------------------------------------------------------------------------------------------
K
K
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
D
--
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
-----------------
53
Blastp_CBE
88.90
99%
-102
- C1 -
-
4DEE
6.1
-
AURKA_HUMAN
A:
[2-272]
---------------------------------------------------------------------------------------------------------------------------
K
K
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
D
--
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
N
C
Q
---------
13
PsiBlast_PDB
88.86
100%
-119
- C1 -
-
5G15
6.3
-
AURKA_HUMAN
A:
[5-269]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
T
--
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
-------------
153
Blastp_CBE
88.83
99%
-118
- C1 -
-
3E5A
8.3
-
AURKA_HUMAN
A:
[2-266]
----------------------------------------------------------------------------------------------------------------------------
K
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
T
--
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
-----------------
544
HHSearch
88.74
100%
-102
- C1 -
-
4DEE
6.1
-
AURKA_HUMAN
A:
[3-272]
----------------------------------------------------------------------------------------------------------------------------
K
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
D
--
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
N
C
Q
---------
83
Blastp_CBE
88.72
99%
-112
- C1 -
-
1OL5
5.6
-
AURKA_HUMAN
A:
[2-266]
--------------------------------------------------------------------------------------------------------------------------
S
K
K
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
T
--
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
-------------------
159
Blastp_CBE
88.60
99%
-106
- C1 -
-
3HA6
9.3
-
AURKA_HUMAN
A:
[2-265]
----------------------------------------------------------------------------------------------------------------------------
K
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
T
--
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
547
HHSearch
88.59
100%
-115
- C1 -
-
5ORX
6.7
-
AURKA_HUMAN
A:
[1-262]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
T
--
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
160
Blastp_CBE
88.51
99%
-111
- C1 -
-
5OSD
6.8
-
AURKA_HUMAN
A:
[1-267]
----------------------------------------------------------------------------------------------------------------------------
K
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
T
--
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
------------
94
Blastp_CBE
88.48
99%
-108
- C1 -
-
5L8K
6.6
-
AURKA_HUMAN
A:
[8-274]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
T
--
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
N
-----------
143
Blastp_CBE
88.27
99%
-112
- C1 -
-
5DR2
4.9
-
AURKA_HUMAN
A:
[4-267]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
A
--
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
-------------
545
HHSearch
88.25
99%
-111
- C1 -
-
5G1X
6.9
-
AURKA_HUMAN
A:
[9-271]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
T
--
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
-----------------
1
PsiBlast_PDB
88.23
100%
-112
- C1 -
-
2J4Z
7.7
-
AURKA_HUMAN
A:
[29-291]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
T
--
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
102
Blastp_CBE
88.21
100%
-113
- C1 -
-
4JAJ
5.2
-
AURKA_HUMAN
A:
[13-277]
----------------------------------------------------------------------------------------------------------------------------
K
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
T
--
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
-----------------
178
Blastp_CBE
88.17
99%
-109
- C1 -
-
5ORX
6.7
-
AURKA_HUMAN
A:
[1-265]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
T
--
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
------------
23
Blastp_CBE
88.12
100%
-110
- C1 -
-
2J4Z
7.7
-
AURKA_HUMAN
B:
[29-297]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
T
--
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
N
C
Q
---------
145
Blastp_CBE
88.11
99%
-112
- C1 -
-
5DOS
4.8
-
AURKA_HUMAN
A:
[4-267]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
------------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
-------------
96
Blastp_CBE
88.08
99%
-111
- C1 -
-
5G1X
6.9
-
AURKA_HUMAN
A:
[9-271]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
T
--
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
-----------------
35
Blastp_CBE
88.05
100%
-118
- C1 -
-
5ZAN
7.7
-
AURKA_HUMAN
A:
[5-267]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
-----------------
183
Blastp_CBE
88.02
99%
-114
- C1 -
-
5ORR
6.8
-
AURKA_HUMAN
A:
[1-265]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
T
--
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
------------
86
Blastp_CBE
87.89
99%
-114
- C1 -
-
3W10
7.4
-
AURKA_HUMAN
A:
[1-263]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
A
--
A
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
546
HHSearch
87.88
99%
-109
- C1 -
-
5L8L
6.3
-
AURKA_HUMAN
A:
[8-271]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
T
--
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
-----------------
107
Blastp_CBE
87.81
99%
-99
- C1 -
-
4J8M
10.6
-
AURKA_HUMAN
A:
[3-268]
----------------------------------------------------------------------------------------------------------------------------
K
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
D
--
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
N
-----------
133
Blastp_CBE
87.80
99%
-107
- C1 -
-
3H10
9.3
-
AURKA_HUMAN
B:
[2-268]
----------------------------------------------------------------------------------------------------------------------------
K
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
A
--
A
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
------------
154
Blastp_CBE
87.76
99%
-106
- C1 -
-
5OS5
7.0
-
AURKA_HUMAN
A:
[1-268]
----------------------------------------------------------------------------------------------------------------------------
K
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
T
--
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
N
-----------
93
Blastp_CBE
87.71
99%
-109
- C1 -
-
5L8L
6.3
-
AURKA_HUMAN
A:
[8-271]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
T
--
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
-----------------
126
Blastp_CBE
87.69
100%
-115
- C1 -
-
1MQ4
5.8
-
AURKA_HUMAN
A:
[7-269]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
-------
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
76
Blastp_CBE
87.68
99%
-114
- C1 -
-
3FDN
6.8
-
AURKA_HUMAN
A:
[4-272]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-------------------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
N
C
Q
---------
44
Blastp_CBE
87.60
99%
-124
- C1 -
-
5ODT
5.4
-
AURKA_HUMAN
A:
[6-272]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
N
F
G
W
---
S
--
V
-
H
----------------------------
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
N
-----------
173
Blastp_CBE
87.58
99%
-111
- C1 -
-
5OS3
6.9
-
AURKA_HUMAN
A:
[1-265]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
T
--
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
------------
121
Blastp_CBE
87.56
100%
-120
- C1 -
-
5OBJ
5.2
-
AURKA_HUMAN
A:
[8-271]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
--------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
-------------
52
Blastp_CBE
87.54
99%
-107
- C1 -
-
4JBO
10.3
-
AURKA_HUMAN
A:
[4-269]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
T
--
D
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
------------
130
Blastp_CBE
87.50
99%
-110
- C1 -
-
5DT4
5.3
-
AURKA_HUMAN
A:
[4-267]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
------------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
-------------
55
Blastp_CBE
87.49
99%
-108
- C1 -
-
4DEB
7.0
-
AURKA_HUMAN
A:
[3-266]
----------------------------------------------------------------------------------------------------------------------------
K
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
D
--
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
134
Blastp_CBE
87.41
99%
-104
- C1 -
-
3H10
9.6
-
AURKA_HUMAN
A:
[2-268]
----------------------------------------------------------------------------------------------------------------------------
K
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
A
--
A
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
------------
182
Blastp_CBE
87.38
99%
-113
- C1 -
-
5ORS
6.9
-
AURKA_HUMAN
A:
[1-265]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
T
--
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
------------
88
Blastp_CBE
87.38
99%
-109
- C1 -
-
6R4D
6.4
-
AURKA_HUMAN
A:
[9-273]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
T
--
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
------------
174
Blastp_CBE
87.35
99%
-109
- C1 -
-
5OS1
6.8
-
AURKA_HUMAN
A:
[1-265]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
T
--
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
------------
185
Blastp_CBE
87.34
99%
-109
- C1 -
-
5ORO
6.6
-
AURKA_HUMAN
A:
[1-265]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
T
--
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
------------
170
Blastp_CBE
87.32
99%
-109
- C1 -
-
5OSE
6.9
-
AURKA_HUMAN
A:
[1-265]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
T
--
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
------------
163
Blastp_CBE
87.29
99%
-114
- C1 -
-
5DT3
6.1
-
AURKA_HUMAN
A:
[4-267]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
T
--
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
-------------
98
Blastp_CBE
87.29
99%
-101
- C1 -
-
5LXM
6.0
-
AURKA_HUMAN
A:
[6-272]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
T
--
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
N
-----------
175
Blastp_CBE
87.26
99%
-108
- C1 -
-
5OS0
6.9
-
AURKA_HUMAN
A:
[1-265]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
T
--
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
------------
176
Blastp_CBE
87.24
99%
-111
- C1 -
-
5ORZ
6.7
-
AURKA_HUMAN
A:
[1-265]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
T
--
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
------------
157
Blastp_CBE
87.21
99%
-115
- C1 -
-
5EW9
8.4
-
AURKA_HUMAN
A:
[8-271]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
----------------
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
-------------
85
Blastp_CBE
87.21
99%
-113
- C1 -
-
3NRM
6.5
-
AURKA_HUMAN
A:
[6-268]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
A
--
A
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
97
Blastp_CBE
87.20
99%
-106
- C1 -
-
4CEG
7.1
-
AURKA_HUMAN
A:
[9-273]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
T
--
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
------------
10
PsiBlast_PDB
87.16
100%
-125
- C1 -
-
4C3P
5.3
-
AURKA_HUMAN
A:
[4-267]
----------------------------------------------------------------------------------------------------------------------------
K
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
T
--
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
82
Blastp_CBE
87.10
99%
-111
- C1 -
-
1OL7
5.7
-
AURKA_HUMAN
A:
[6-268]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
T
--
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
-----------------
180
Blastp_CBE
86.98
99%
-108
- C1 -
-
5ORV
6.9
-
AURKA_HUMAN
A:
[1-265]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
T
--
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
------------
177
Blastp_CBE
86.97
99%
-112
- C1 -
-
5ORY
6.6
-
AURKA_HUMAN
A:
[1-265]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
T
--
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
------------
171
Blastp_CBE
86.94
99%
-108
- C1 -
-
5OS6
6.8
-
AURKA_HUMAN
A:
[1-265]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
T
--
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
------------
91
Blastp_CBE
86.89
99%
-106
- C1 -
-
6R4A
7.3
-
AURKA_HUMAN
A:
[9-273]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
T
--
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
------------
84
Blastp_CBE
86.87
99%
-107
- C1 -
-
4BN1
7.3
-
AURKA_HUMAN
A:
[8-270]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
M
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
T
--
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
184
Blastp_CBE
86.85
99%
-106
- C1 -
-
5ORP
6.7
-
AURKA_HUMAN
A:
[1-265]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
T
--
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
------------
179
Blastp_CBE
86.85
99%
-110
- C1 -
-
5ORW
6.8
-
AURKA_HUMAN
A:
[1-265]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
T
--
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
------------
139
Blastp_CBE
86.83
99%
-110
- C1 -
-
5DT0
6.4
-
AURKA_HUMAN
A:
[4-267]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
------------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
-------------
89
Blastp_CBE
86.78
99%
-106
- C1 -
-
6R4C
7.2
-
AURKA_HUMAN
A:
[9-273]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
T
--
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
------------
140
Blastp_CBE
86.77
99%
-111
- C1 -
-
5DRD
6.2
-
AURKA_HUMAN
A:
[4-267]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
------------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
-------------
81
Blastp_CBE
86.71
99%
-110
- C1 -
-
6I2U
8.6
-
AURKA_HUMAN
A:
[9-273]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
T
--
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
------------
75
Blastp_CBE
86.67
99%
-115
- C1 -
-
3K5U
7.1
-
AURKA_HUMAN
A:
[4-272]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
----------------------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
N
C
Q
---------
92
Blastp_CBE
86.63
99%
-111
- C1 -
-
6R49
6.0
-
AURKA_HUMAN
A:
[9-273]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
------------
172
Blastp_CBE
86.55
99%
-108
- C1 -
-
5OS4
6.9
-
AURKA_HUMAN
A:
[1-265]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
T
--
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
------------
71
Blastp_CBE
86.52
99%
-107
- C1 -
-
3UO4
8.3
-
AURKA_HUMAN
A:
[2-267]
---------------------------------------------------------------------------------------------------------------------------
K
K
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
D
--
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
-----------------
18
PsiBlast_PDB
86.48
100%
-117
- C1 -
-
4ZS0
5.0
-
AURKA_HUMAN
A:
[9-270]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
149
Blastp_CBE
86.47
99%
-117
- C1 -
-
4DHF
7.2
-
AURKA_HUMAN
B:
[8-269]
-------------------------------------------------------------------------------------------------------------------------------
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
--------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
-----------------
8
PsiBlast_PDB
86.42
100%
-115
- C1 -
-
2XNG
7.1
-
AURKA_HUMAN
A:
[7-269]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
---------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
-----------------
186
Blastp_CBE
86.40
99%
-106
- C1 -
-
5ORN
6.7
-
AURKA_HUMAN
A:
[1-265]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
T
--
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
------------
56
Blastp_CBE
86.37
99%
-106
- C1 -
-
4DEA
7.4
-
AURKA_HUMAN
A:
[2-267]
---------------------------------------------------------------------------------------------------------------------------
K
K
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
D
--
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
-----------------
187
Blastp_CBE
86.34
99%
-107
- C1 -
-
5ORL
7.3
-
AURKA_HUMAN
A:
[1-265]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
T
--
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
------------
65
Blastp_CBE
86.29
99%
-107
- C1 -
-
3UOH
7.7
-
AURKA_HUMAN
B:
[4-267]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
D
--
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
-----------------
141
Blastp_CBE
86.28
99%
-122
- C1 -
-
5DR9
6.8
-
AURKA_HUMAN
A:
[4-267]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-----------------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
-------------
38
Blastp_CBE
86.26
99%
-120
- C1 -
-
4O0U
4.3
-
AURKA_HUMAN
A:
[5-270]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
R
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
---------------------
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
------------
181
Blastp_CBE
86.20
99%
-105
- C1 -
-
5ORT
6.6
-
AURKA_HUMAN
A:
[1-265]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
T
--
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
------------
156
Blastp_CBE
86.16
99%
-114
- C1 -
-
2W1C
7.5
-
AURKA_HUMAN
A:
[7-269]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
T
--
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
-----------------
66
Blastp_CBE
86.05
99%
-106
- C1 -
-
3UOH
7.8
-
AURKA_HUMAN
A:
[4-267]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
D
--
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
-----------------
142
Blastp_CBE
86.03
99%
-120
- C1 -
-
5DR6
6.8
-
AURKA_HUMAN
A:
[4-267]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-----------------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
-------------
40
Blastp_CBE
86.02
99%
-117
- C1 -
-
5AAF
8.8
-
AURKA_HUMAN
A:
[8-270]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
----------------------------
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
113
Blastp_CBE
86.00
99%
-107
- C1 -
-
2DWB
6.1
-
AURKA_HUMAN
A:
[8-271]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
-------
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
-----------------
169
Blastp_CBE
85.95
99%
-104
- C1 -
-
5OSF
6.9
-
AURKA_HUMAN
A:
[1-265]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
T
--
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
------------
137
Blastp_CBE
85.95
99%
-128
- C1 -
-
3H0Z
9.6
-
AURKA_HUMAN
A:
[5-265]
-------------------------------------------------------------------------------------------------------------------------------
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
-----------------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
144
Blastp_CBE
85.90
99%
-117
- C1 -
-
5DPV
6.3
-
AURKA_HUMAN
A:
[4-266]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
---------------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
-----------------
90
Blastp_CBE
85.89
99%
-107
- C1 -
-
6R4B
6.7
-
AURKA_HUMAN
A:
[9-273]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
T
--
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
------------
99
Blastp_CBE
85.88
99%
-113
- C1 -
-
4UZD
8.7
-
AURKA_HUMAN
B:
[2-266]
----------------------------------------------------------------------------------------------------------------------------
K
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
----------------------
R
---
R
T
--
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
-----------------
59
Blastp_CBE
85.88
99%
-109
- C1 -
-
3UOL
8.0
-
AURKA_HUMAN
B:
[5-267]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
D
--
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
-----------------
150
Blastp_CBE
85.76
99%
-110
- C1 -
-
4DHF
7.3
-
AURKA_HUMAN
A:
[8-269]
-------------------------------------------------------------------------------------------------------------------------------
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
--------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
-----------------
60
Blastp_CBE
85.69
99%
-110
- C1 -
-
3UOL
8.0
-
AURKA_HUMAN
A:
[5-267]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
D
--
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
-----------------
64
Blastp_CBE
85.63
99%
-108
- C1 -
-
3UOJ
7.0
-
AURKA_HUMAN
A:
[5-267]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
D
--
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
-----------------
68
Blastp_CBE
85.61
99%
-103
- C1 -
-
3UO6
7.0
-
AURKA_HUMAN
B:
[4-267]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
D
--
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
-----------------
37
Blastp_CBE
85.58
99%
-117
- C1 -
-
4O0W
4.1
-
AURKA_HUMAN
A:
[4-270]
----------------------------------------------------------------------------------------------------------------------------
K
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
Y
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
-----------------------
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
------------
57
Blastp_CBE
85.56
99%
-108
- C1 -
-
3UP7
7.3
-
AURKA_HUMAN
A:
[2-265]
---------------------------------------------------------------------------------------------------------------------------
K
K
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
D
--
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
-------------------
69
Blastp_CBE
85.54
99%
-103
- C1 -
-
3UO6
6.8
-
AURKA_HUMAN
A:
[4-267]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
D
--
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
-----------------
12
PsiBlast_PDB
85.49
100%
-107
- C1 -
-
4O0S
4.3
-
AURKA_HUMAN
A:
[5-270]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
---
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
------------
49
Blastp_CBE
85.48
99%
-110
- C1 -
-
6HJJ
8.2
-
AURKA_HUMAN
A:
[9-275]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
C
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-------------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
N
A
----------
148
Blastp_CBE
85.47
99%
-109
- C1 -
-
5OS2
5.9
-
AURKA_HUMAN
A:
[1-265]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
--------------
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
------------
63
Blastp_CBE
85.40
99%
-108
- C1 -
-
3UOJ
6.5
-
AURKA_HUMAN
B:
[5-267]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
D
--
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
-----------------
188
Blastp_CBE
85.39
95%
-121
- C1 -
-
3DJ7
9.2
-
AURKA_MOUSE
A:
[7-269]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
T
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
R
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
T
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
N
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
---------------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
----
H
T
Y
Q
E
T
Y
R
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
--
R
-----
L
-----
T
L
A
-
E
V
L
E
H
P
W
I
-
K
A
N
S
S
------------------
54
Blastp_CBE
85.35
99%
-102
- C1 -
-
4DED
6.7
-
AURKA_HUMAN
A:
[2-266]
---------------------------------------------------------------------------------------------------------------------------
K
K
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
D
--
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
50
Blastp_CBE
85.29
99%
-121
- C1 -
-
4JBQ
7.5
-
AURKA_HUMAN
A:
[4-269]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
----------------------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
------------
138
Blastp_CBE
85.28
99%
-125
- C1 -
-
3H0Y
7.8
-
AURKA_HUMAN
A:
[3-265]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
-----------------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
194
Blastp_CBE
85.24
95%
-118
- C1 -
-
3D14
9.2
-
AURKA_MOUSE
A:
[5-269]
----------------------------------------------------------------------------------------------------------------------------
K
R
Q
W
T
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
R
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
T
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
N
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
---------------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
----
H
T
Y
Q
E
T
Y
R
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
--
R
-----
L
-----
T
L
A
-
E
V
L
E
H
P
W
I
-
K
A
N
S
S
------------------
6
PsiBlast_PDB
85.24
99%
-115
- C1 -
-
6CPG
3.9
-
AURKA_HUMAN
A:
[9-269]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
-------------------------------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
-------------------
73
Blastp_CBE
85.23
99%
-108
- C1 -
-
3UNZ
7.2
-
AURKA_HUMAN
A:
[5-267]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
D
--
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
-----------------
120
Blastp_CBE
85.18
100%
-121
- C1 -
-
5OBR
7.0
-
AURKA_HUMAN
A:
[7-271]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
-----------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
-------------
62
Blastp_CBE
85.14
99%
-103
- C1 -
-
3UOK
7.1
-
AURKA_HUMAN
A:
[3-267]
----------------------------------------------------------------------------------------------------------------------------
K
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
D
--
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
-----------------
14
PsiBlast_PDB
85.11
100%
-115
- C1 -
-
2X6D
8.4
-
AURKA_HUMAN
A:
[8-270]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-------
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
--------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
123
Blastp_CBE
85.06
100%
-120
- C1 -
-
3MYG
6.9
-
AURKA_HUMAN
A:
[7-269]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
------------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
72
Blastp_CBE
85.05
99%
-108
- C1 -
-
3UNZ
7.5
-
AURKA_HUMAN
B:
[5-267]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
D
--
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
-----------------
61
Blastp_CBE
84.99
99%
-102
- C1 -
-
3UOK
7.0
-
AURKA_HUMAN
B:
[3-267]
----------------------------------------------------------------------------------------------------------------------------
K
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
D
--
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
-----------------
74
Blastp_CBE
84.91
99%
-113
- C1 -
-
3M11
10.2
-
AURKA_HUMAN
A:
[4-269]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
-----------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
------------
42
Blastp_CBE
84.89
99%
-119
- C1 -
-
5AAD
7.5
-
AURKA_HUMAN
A:
[9-270]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
---------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
48
Blastp_CBE
84.88
99%
-111
- C1 -
-
6HJK
5.1
-
AURKA_HUMAN
A:
[9-273]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
C
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
------------------------------
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
------------
5
PsiBlast_PDB
84.85
99%
-104
- C1 -
-
6CPF
4.7
-
AURKA_HUMAN
A:
[10-274]
-------------------------------------------------------------------------------------------------------------------------------
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
-------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
N
-----------
151
Blastp_CBE
84.83
99%
-116
- C1 -
-
3R22
7.2
-
AURKA_HUMAN
A:
[6-269]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
--------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
-----------------
116
Blastp_CBE
84.83
100%
-117
- C1 -
-
2W1E
6.3
-
AURKA_HUMAN
A:
[7-269]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-------------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
-----------------
39
Blastp_CBE
84.82
99%
-120
- C1 -
-
5AAG
6.9
-
AURKA_HUMAN
A:
[9-270]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
----------------------------
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
32
Blastp_CBE
84.80
100%
-121
- C1 -
-
6GRA
10.7
-
AURKA_HUMAN
A:
[8-271]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---------------------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
-----------------
122
Blastp_CBE
84.78
100%
-117
- C1 -
-
3VAP
8.9
-
AURKA_HUMAN
A:
[8-269]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
--------------------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
117
Blastp_CBE
84.70
100%
-122
- C1 -
-
2W1D
4.5
-
AURKA_HUMAN
A:
[7-269]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-------------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
---
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
-----------------
119
Blastp_CBE
84.66
100%
-127
- C1 -
-
6C2R
9.3
-
AURKA_HUMAN
A:
[9-270]
-------------------------------------------------------------------------------------------------------------------------------
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
--------------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
-----------------
152
Blastp_CBE
84.59
99%
-120
- C1 -
-
3R21
6.7
-
AURKA_HUMAN
A:
[7-269]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-------------------------
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
-----------------
115
Blastp_CBE
84.59
100%
-117
- C1 -
-
2W1F
5.9
-
AURKA_HUMAN
A:
[7-269]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
-----------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
-----------------
11
PsiBlast_PDB
84.54
100%
-120
- C1 -
-
4C3R
5.9
-
AURKA_HUMAN
A:
[6-267]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
-----------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
155
Blastp_CBE
84.51
99%
-119
- C1 -
-
2W1G
5.3
-
AURKA_HUMAN
A:
[7-269]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
--------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
-----------------
118
Blastp_CBE
84.44
100%
-132
- C1 -
-
6C2T
8.0
-
AURKA_HUMAN
A:
[9-269]
-------------------------------------------------------------------------------------------------------------------------------
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-----------------------
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
43
Blastp_CBE
84.44
99%
-115
- C1 -
-
2WTW
7.5
-
AURKA_HUMAN
A:
[10-271]
-------------------------------------------------------------------------------------------------------------------------------
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
R
G
E
V
Y
K
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
---------------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
-----------------
95
Blastp_CBE
84.41
99%
-113
- C1 -
-
5L8J
5.7
-
AURKA_HUMAN
A:
[8-273]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
-----------------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
------------
193
Blastp_CBE
84.34
95%
-125
- C1 -
-
3D15
8.8
-
AURKA_MOUSE
A:
[7-269]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
T
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
R
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
T
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
N
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
----------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
----
H
T
Y
Q
E
T
Y
R
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
--
R
-----
L
-----
T
L
A
-
E
V
L
E
H
P
W
I
-
K
A
N
S
S
------------------
51
Blastp_CBE
84.25
99%
-112
- C1 -
-
4JBP
10.7
-
AURKA_HUMAN
A:
[4-268]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
-----------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
-------------
34
Blastp_CBE
84.23
100%
-123
- C1 -
-
4ZTS
9.6
-
AURKA_HUMAN
A:
[9-270]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
-----------------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
33
Blastp_CBE
84.17
100%
-113
- C1 -
-
5ONE
9.5
-
AURKA_HUMAN
A:
[9-273]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
-----------------------
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
------------
100
Blastp_CBE
84.16
99%
-118
- C1 -
-
4UZD
7.8
-
AURKA_HUMAN
A:
[4-265]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
-----------------------
R
---
R
T
--
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
19
PsiBlast_PDB
84.16
100%
-128
- C1 -
-
4ZTQ
7.3
-
AURKA_HUMAN
A:
[9-270]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-------------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
------
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
47
Blastp_CBE
84.15
100%
-130
- C1 -
-
3W16
6.0
-
AURKA_HUMAN
A:
[1-263]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-------------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
------
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
190
Blastp_CBE
84.10
95%
-142
- C1 -
-
3DJ5
10.1
-
AURKA_MOUSE
A:
[9-269]
-------------------------------------------------------------------------------------------------------------------------------
W
T
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
R
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
T
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
N
---
G
E
----
L
K
I
A
D
F
G
W
---------------------------
T
--
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
----
H
T
Y
Q
E
T
Y
R
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
--
R
-----
L
-----
T
L
A
-
E
V
L
E
H
P
W
I
-
K
A
N
S
S
------------------
135
Blastp_CBE
84.10
99%
-126
- C1 -
-
3H0Z
9.2
-
AURKA_HUMAN
C:
[3-265]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
------------------------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
87
Blastp_CBE
84.09
99%
-120
- C1 -
-
2XRU
6.8
-
AURKA_HUMAN
A:
[3-265]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
------------------------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
129
Blastp_CBE
84.05
100%
-119
- C1 -
-
3O50
7.8
-
AURKA_HUMAN
A:
[2-264]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---------------------------------------
T
L
D
Y
L
P
P
E
M
I
E
----
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
131
Blastp_CBE
84.00
99%
-128
- C1 -
-
3P9J
6.5
-
AURKA_HUMAN
A:
[3-265]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-------------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
------
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
29
Blastp_CBE
83.98
99%
-115
- C1 -
-
6CPG
5.1
-
AURKA_HUMAN
D:
[9-270]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
----------------------------
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
16
PsiBlast_PDB
83.97
100%
-117
- C1 -
-
4BYI
7.0
-
AURKA_HUMAN
A:
[8-270]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
--------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
41
Blastp_CBE
83.94
99%
-117
- C1 -
-
5AAE
7.9
-
AURKA_HUMAN
A:
[8-270]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-------------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
192
Blastp_CBE
83.92
95%
-124
- C1 -
-
3D2I
8.9
-
AURKA_MOUSE
A:
[8-269]
------------------------------------------------------------------------------------------------------------------------------
Q
W
T
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
R
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
T
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
N
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-----------------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
----
H
T
Y
Q
E
T
Y
R
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
--
R
-----
L
-----
T
L
A
-
E
V
L
E
H
P
W
I
-
K
A
N
S
S
------------------
124
Blastp_CBE
83.82
100%
-136
- C1 -
-
2X81
6.0
-
AURKA_HUMAN
A:
[8-269]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
---
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
------------------------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
158
Blastp_CBE
83.80
98%
-127
- C1 -
-
4PRJ
7.5
-
AURKA_HUMAN
A:
[3-266]
----------------------------------------------------------------------------------------------------------------------------
K
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
---
G
N
V
Y
L
A
-
R
E
---
K
---
N
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
S
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
K
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
------------------------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
D
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
80
Blastp_CBE
83.65
99%
-122
- C1 -
-
2C6E
10.8
-
AURKA_HUMAN
A:
[9-271]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
----------------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
-----------------
189
Blastp_CBE
83.63
95%
-139
- C1 -
-
3DJ6
11.0
-
AURKA_MOUSE
A:
[9-269]
-------------------------------------------------------------------------------------------------------------------------------
W
T
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
R
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
T
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
N
---
G
E
----
L
K
I
A
D
F
G
W
---------------------------
T
--
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
----
H
T
Y
Q
E
T
Y
R
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
--
R
-----
L
-----
T
L
A
-
E
V
L
E
H
P
W
I
-
K
A
N
S
S
------------------
106
Blastp_CBE
83.59
99%
-120
- C1 -
-
3LAU
6.3
-
AURKA_HUMAN
A:
[2-268]
----------------------------------------------------------------------------------------------------------------------------
K
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
------------------------------------------
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
------------
31
Blastp_CBE
83.42
100%
-129
- C1 -
-
4C3P
4.5
-
AURKA_HUMAN
D:
[4-269]
----------------------------------------------------------------------------------------------------------------------------
K
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
------------------
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
-------------
132
Blastp_CBE
83.33
99%
-112
- C1 -
-
3H10
9.1
-
AURKA_HUMAN
D:
[3-265]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
-----------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
3
PsiBlast_PDB
83.30
100%
-122
- C1 -
-
1MUO
3.9
-
AURKA_HUMAN
A:
[22-282]
-------------------------------------------------------------------------------------------------------------------------------
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
----------------------------
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
77
Blastp_CBE
83.23
100%
-117
- C1 -
-
2J50
7.4
-
AURKA_HUMAN
B:
[5-265]
-------------------------------------------------------------------------------------------------------------------------------
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-----------------------
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
-----
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
162
Blastp_CBE
83.21
98%
-116
- C1 -
-
3COH
7.1
-
AURKA_HUMAN
A:
[5-265]
-------------------------------------------------------------------------------------------------------------------------------
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
N
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
S
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
K
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
-----------------------------------
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
D
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
20
PsiBlast_PDB
83.19
100%
-119
- C1 -
-
4ZTR
9.6
-
AURKA_HUMAN
A:
[9-270]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
--------------------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
79
Blastp_CBE
83.09
99%
-116
- C1 -
-
2C6E
9.4
-
AURKA_HUMAN
B:
[9-270]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
-----------------------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
161
Blastp_CBE
82.87
98%
-117
- C1 -
-
3COH
7.1
-
AURKA_HUMAN
B:
[5-265]
-------------------------------------------------------------------------------------------------------------------------------
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
N
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
S
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
K
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
-----------------------------------
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
D
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
7
PsiBlast_PDB
82.84
99%
-118
- C1 -
-
6C83
5.1
-
AURKA_HUMAN
A:
[9-271]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
----------------------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
-----------------
30
Blastp_CBE
82.83
99%
-115
- C1 -
-
6C83
4.4
-
AURKA_HUMAN
B:
[9-270]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
----------------------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
17
PsiBlast_PDB
82.74
100%
-116
- C1 -
-
4BYJ
6.2
-
AURKA_HUMAN
A:
[8-270]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
------------------------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
191
Blastp_CBE
82.72
95%
-132
- C1 -
-
3D2K
8.5
-
AURKA_MOUSE
A:
[9-269]
-------------------------------------------------------------------------------------------------------------------------------
W
T
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
R
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
T
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
N
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
------------------------------
T
L
D
Y
L
P
P
E
M
I
------
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
----
H
T
Y
Q
E
T
Y
R
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
--
R
-----
L
-----
T
L
A
-
E
V
L
E
H
P
W
I
-
K
A
N
S
S
------------------
104
Blastp_CBE
82.70
99%
-119
- C1 -
-
4UZH
5.5
-
AURKA_HUMAN
A:
[2-268]
----------------------------------------------------------------------------------------------------------------------------
K
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
------------------------------------------
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
------------
114
Blastp_CBE
82.63
99%
-117
- C1 -
-
2XNE
6.2
-
AURKA_HUMAN
A:
[7-268]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
----------
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
N
F
G
W
---
S
--
V
-
H
--
A
-
P
-------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
108
Blastp_CBE
82.60
99%
-113
- C1 -
-
2C6D
5.6
-
AURKA_HUMAN
A:
[3-266]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
-----------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
-----------------
78
Blastp_CBE
82.58
100%
-117
- C1 -
-
2J50
7.4
-
AURKA_HUMAN
A:
[5-265]
-------------------------------------------------------------------------------------------------------------------------------
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-----------------------
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
-----
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
22
Blastp_CBE
82.54
100%
-136
- C1 -
-
3EFW
8.7
-
AURKA_HUMAN
A:
[126-388]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
------------------------------------------
L
D
Y
L
P
P
E
M
I
--------
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
36
Blastp_CBE
82.42
99%
-122
- C1 -
-
1OL6
4.2
-
AURKA_HUMAN
A:
[7-266]
-------------------------------------------------------------------------------------------------------------------------------
W
A
L
E
D
F
E
I
G
R
P
L
G
K
-
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
---
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
N
F
G
W
---
S
--
V
-
H
------------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
-
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
-------------------
105
Blastp_CBE
82.36
99%
-117
- C1 -
-
4UYN
8.6
-
AURKA_HUMAN
A:
[2-268]
----------------------------------------------------------------------------------------------------------------------------
K
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
----
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
-----------------------------------------
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
------------
195
Blastp_CBE
82.34
94%
-130
- C1 -
-
3DAJ
7.5
-
AURKA_MOUSE
A:
[8-269]
------------------------------------------------------------------------------------------------------------------------------
Q
W
T
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
R
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
T
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
N
---
G
E
----
L
K
I
A
D
F
G
W
---
S
-----------------------------------
T
L
D
Y
L
P
P
E
M
I
-----
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
----
H
T
Y
Q
E
T
Y
R
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
--
R
-----
L
-----
T
L
A
-
E
V
L
E
H
P
W
I
-
K
A
N
S
S
------------------
101
Blastp_CBE
82.25
99%
-116
- C1 -
-
3QBN
5.3
-
AURKA_HUMAN
A:
[4-266]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
---------------------------------
T
-
L
----
S
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
168
Blastp_CBE
82.13
99%
-124
- C1 -
-
2WQE
5.6
-
AURKA_HUMAN
A:
[1-262]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
R
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
-----------------------------------------
G
T
L
D
Y
L
P
P
E
M
I
------
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
127
Blastp_CBE
81.42
100%
-135
- C1 -
-
3O51
7.0
-
AURKA_HUMAN
A:
[2-264]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
------------------------------------------
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
128
Blastp_CBE
80.77
100%
-119
- C1 -
-
3O50
8.7
-
AURKA_HUMAN
B:
[2-265]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
-----------------------------
T
--
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
-----
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
-----------------
21
Blastp_CBE
80.69
100%
-128
- C1 -
-
3EFW
9.6
-
AURKA_HUMAN
B:
[126-389]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
------------------------------------------
L
D
Y
L
P
P
E
M
I
E
-------
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
-----------------
15
PsiBlast_PDB
80.54
100%
-116
- C1 -
-
2X6E
7.6
-
AURKA_HUMAN
A:
[8-270]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
------------------------------
T
L
D
Y
L
P
P
E
M
I
E
----
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
103
Blastp_CBE
80.36
100%
-115
- C1 -
-
4JAI
8.6
-
AURKA_HUMAN
A:
[14-278]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
-----------------------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
-------------
9
PsiBlast_PDB
80.09
100%
-111
- C1 -
-
4B0G
8.0
-
AURKA_HUMAN
A:
[6-271]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
-------
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
--------------------------------
T
L
D
Y
L
P
P
E
M
I
E
----
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
------------
548
HHSearch
79.36
68%
-109
- C1 -
-
4C2V
8.0
-
AUKBA_XENLA
B:
[11-281]
-----------------------------------------------------------------------------------------------------------------------------
R
K
F
T
I
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
N
K
F
I
M
A
L
K
V
L
F
K
-
S
Q
L
E
-
K
-
E
G
-
V
E
H
Q
L
R
R
E
I
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
-
G
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
L
---
R
---
R
R
--
T
-
M
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
-
H
D
-
E
-
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
----
P
S
H
T
E
T
H
R
R
I
--
V
N
---
V
D
----
L
K
F
--
P
----
P
F
--
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
--
R
-----
L
-----
P
L
K
-
G
V
M
E
H
P
W
V
-
K
A
N
S
R
R
---
V
L
P
P
V
Y
Q
-------
136
Blastp_CBE
79.23
99%
-122
- C1 -
-
3H0Z
8.9
-
AURKA_HUMAN
B:
[3-265]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
------
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
------------------------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
45
Blastp_CBE
78.94
100%
-129
- C1 -
-
3W18
9.0
-
AURKA_HUMAN
B:
[1-263]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
--------------
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
--------------------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
------
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
543
HHSearch
78.11
70%
-106
- C1 -
-
4C2W
5.6
-
AUKBA_XENLA
A:
[11-275]
-------------------------------------------------------------------------------------------------------------------------------
F
T
I
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
N
K
F
I
M
A
L
K
V
L
F
K
-
S
Q
L
E
-
K
-
E
G
-
V
E
H
Q
L
R
R
E
I
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
-
G
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
L
---
R
---
R
R
--
T
-
M
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
-
H
D
-
E
-
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
----
P
S
H
T
E
T
H
R
R
I
--
V
N
---
V
D
----
L
K
F
--
P
----
P
F
--
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
--
R
-----
L
-----
P
L
K
-
G
V
M
E
H
P
W
V
-
K
A
N
S
R
R
---
V
L
P
-----------
216
Blastp_CBE
77.65
69%
-117
- C1 -
-
5EYK
9.1
-
AUKBA_XENLA
A:
[8-269]
-------------------------------------------------------------------------------------------------------------------------------
F
T
I
D
D
F
D
I
V
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
N
K
F
I
M
A
L
K
V
L
F
K
-
S
Q
L
E
-
K
-
E
G
-
V
E
H
Q
L
R
R
E
I
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
-
G
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
----------
R
---
R
---
R
-
M
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
-
H
D
-
E
-
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
----
P
S
H
T
E
T
H
R
R
I
--
V
N
---
V
D
----
L
K
F
--
P
----
P
F
--
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
--
R
-----
L
-----
P
L
K
-
G
V
M
E
H
P
W
V
-
K
A
N
S
R
R
-----------------
46
Blastp_CBE
77.02
100%
-130
- C1 -
-
3W18
8.0
-
AURKA_HUMAN
A:
[1-263]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
--
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
--------
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
------------------------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
------
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
------------------
217
Blastp_CBE
75.28
71%
-125
- C1 -
-
4AF3
7.7
-
AURKB_HUMAN
A:
[18-286]
-----------------------------------------------------------------------------------------------------------------------------
R
H
F
T
I
D
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
K
S
H
F
I
V
A
L
K
V
L
F
K
-
S
Q
I
E
-
K
-
E
G
-
V
E
H
Q
L
R
R
E
I
E
--
I
Q
A
H
L
H
H
P
N
I
L
R
L
Y
N
Y
F
Y
D
R
R
R
I
Y
L
I
L
E
Y
A
P
R
G
E
L
Y
K
E
L
Q
K
S
-
C
T
-
F
D
E
Q
R
T
A
T
I
M
E
E
L
A
D
A
L
M
Y
C
H
G
-
K
K
V
I
H
R
D
I
K
P
E
N
L
L
L
G
L
K
---
G
E
----
L
K
I
A
D
F
G
-----------------------------------------
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
N
-
E
-
K
V
D
L
W
C
I
G
V
L
C
Y
E
L
L
V
G
N
P
P
F
E
S
----
A
S
H
N
E
T
Y
R
R
I
--
V
K
---
V
D
----
L
K
F
--
P
----
A
S
--
V
P
T
G
A
Q
D
L
I
S
K
L
L
R
H
N
P
S
E
--
R
-----
L
-----
P
L
A
-
Q
V
S
A
H
P
W
V
-
R
A
N
S
R
R
VLP
P
S
------------
111
Blastp_CBE
73.25
98%
-53
- C1 -
-
2WTV
9.5
-
AURKA_HUMAN
B:
[8-271]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
R
G
E
V
Y
K
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
----------
L
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
N
-----------
196
Blastp_CBE
73.17
68%
-114
- C1 -
-
4B8L
4.7
-
AUKBA_XENLA
A:
[11-275]
------------------------------------------------------------------------------------------------------------------------------
K
F
T
I
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
N
K
F
I
M
A
L
K
V
L
F
K
-
S
Q
L
E
-
K
-
E
G
-
V
E
H
Q
L
R
R
E
I
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
-
G
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
---
G
E
----
L
K
I
A
D
F
-----------------------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
-
H
D
-
E
-
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
----
P
S
H
T
E
T
H
R
R
I
--
V
N
---
V
D
----
L
K
F
--
P
----
P
F
--
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
--
R
-----
L
-----
P
L
K
-
G
V
M
E
H
P
W
V
-
K
A
N
S
R
R
VL---------------
109
Blastp_CBE
72.92
98%
-49
- C1 -
-
2WTV
8.9
-
AURKA_HUMAN
D:
[7-271]
----------------------------------------------------------------------------------------------------------------------------
K
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
R
G
E
V
Y
K
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
----------
L
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
N
-----------
110
Blastp_CBE
72.53
98%
-52
- C1 -
-
2WTV
9.2
-
AURKA_HUMAN
C:
[8-271]
-----------------------------------------------------------------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
R
G
E
V
Y
K
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
----------
L
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
N
-----------
112
Blastp_CBE
72.37
98%
-53
- C1 -
-
2WTV
8.9
-
AURKA_HUMAN
A:
[7-271]
----------------------------------------------------------------------------------------------------------------------------
K
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
R
G
E
V
Y
K
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
---
R
----------
L
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
-
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
E
T
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
--
R
-----
P
-----
M
L
R
-
E
V
L
E
H
P
W
I
-
T
A
N
S
S
K
---
P
S
N
-----------
218
Blastp_CBE
72.30
72%
-93
- C1 -
-
6GR9
7.6
-
AURKC_HUMAN
A:
[9-268]
---------------------------------------------------------------------------------------------------------------------------------
V
D
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
L
---
K
---
E
S
H
F
I
V
A
L
K
V
L
F
K
-
S
Q
I
E
-
K
-
E
G
-
L
E
H
Q
L
R
R
E
I
E
--
I
Q
A
H
L
Q
H
P
N
I
L
R
L
Y
N
Y
F
H
D
A
R
R
V
Y
L
I
L
E
Y
A
P
R
G
E
L
Y
K
E
L
Q
K
S
-
D
K
-
L
D
E
Q
R
T
A
T
I
I
E
E
L
A
D
A
L
T
Y
C
H
D
-
K
K
V
I
H
R
D
I
K
P
E
N
L
L
L
G
F
R
---
G
E
----
V
K
I
A
D
F
G
W
---
S
--
V
-
H
--
T
-
P
-
S
--
L
---
R
---
R
---
K
-
M
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
T
-
Y
D
-
E
-
K
V
D
L
W
C
I
G
V
L
C
Y
E
L
L
V
G
Y
P
P
F
E
S
----
A
S
H
S
E
T
Y
R
R
I
--
L
K
---
V
D
----
V
R
F
--
P
----
L
S
--
M
P
L
G
A
R
D
L
I
S
R
L
L
R
Y
Q
P
L
E
--
R
-----
L
-----
P
L
A
-
Q
I
L
K
H
P
W
V
-
Q
A
H
S
R
R
-----------------
201
Blastp_CBE
70.59
70%
-87
- C1 -
-
2VGP
6.0
-
AUKBA_XENLA
B:
[5-272]
-------------------------------------------------------------------------------------------------------------------------
E
M
P
K
R
K
F
T
I
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
N
K
F
I
M
A
L
K
V
L
F
K
-
S
Q
L
E
-
K
-
E
G
-
V
E
H
Q
L
R
R
E
I
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
-
G
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
L
---
R
---
R
---
R
-
M
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
-
H
D
-
E
-
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
----
P
S
H
T
E
T
H
R
R
I
--
V
N
---
V
D
----
L
K
F
--
P
----
P
F
--
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
--
R
-----
L
-----
P
L
K
-
G
V
M
E
H
P
W
V
-
K
A
N
S
R
R
-----------------
219
Blastp_CBE
70.36
72%
-84
- C1 -
-
6GR8
10.9
-
AURKC_HUMAN
A:
[9-268]
---------------------------------------------------------------------------------------------------------------------------------
V
D
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
L
---
K
---
E
S
H
F
I
V
A
L
K
V
L
F
K
-
S
Q
I
E
-
K
-
E
G
-
L
E
H
Q
L
R
R
E
I
E
--
I
Q
A
H
L
Q
H
P
N
I
L
R
L
Y
N
Y
F
H
D
A
R
R
V
Y
L
I
L
E
Y
A
P
R
G
E
L
Y
K
E
L
Q
K
S
-
D
K
-
L
D
E
Q
R
T
A
T
I
I
E
E
L
A
D
A
L
T
Y
C
H
D
-
K
K
V
I
H
R
D
I
K
P
E
N
L
L
L
G
F
R
---
G
E
----
V
K
I
A
D
F
G
W
---
S
--
V
-
H
--
T
-
P
-
S
--
L
---
R
---
R
---
K
-
M
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
T
-
Y
D
-
E
-
K
V
D
L
W
C
I
G
V
L
C
Y
E
L
L
V
G
Y
P
P
F
E
S
----
A
S
H
S
E
T
Y
R
R
I
--
L
K
---
V
D
----
V
R
F
--
P
----
L
S
--
M
P
L
G
A
R
D
L
I
S
R
L
L
R
Y
Q
P
L
E
--
R
-----
L
-----
P
L
A
-
Q
I
L
K
H
P
W
V
-
Q
A
H
S
R
R
-----------------
165
Blastp_CBE
70.12
100%
-151
- C1 -
-
3W2C
8.5
-
AURKA_HUMAN
E:
[1-261]
-------------------------------------------------------------------------------------------------------------------------------
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
---------------
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
-----------
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
------------------------------------------
T
L
D
Y
L
P
P
E
M
I
E
----------
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
--
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
------------------------
H
P
W
I
-
T
A
N
S
S
------------------
209
Blastp_CBE
69.69
70%
-86
- C1 -
-
4C2V
8.0
-
AUKBA_XENLA
B:
[7-274]
-------------------------------------------------------------------------------------------------------------------------
E
M
P
K
R
K
F
T
I
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
N
K
F
I
M
A
L
K
V
L
F
K
-
S
Q
L
E
-
K
-
E
G
-
V
E
H
Q
L
R
R
E
I
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
-
G
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
L
---
R
---
R
---
R
-
M
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
-
H
D
-
E
-
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
----
P
S
H
T
E
T
H
R
R
I
--
V
N
---
V
D
----
L
K
F
--
P
----
P
F
--
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
--
R
-----
L
-----
P
L
K
-
G
V
M
E
H
P
W
V
-
K
A
N
S
R
R
-----------------
206
Blastp_CBE
69.68
70%
-86
- C1 -
-
2VRX
8.1
-
AUKBA_XENLA
A:
[11-273]
------------------------------------------------------------------------------------------------------------------------------
K
F
T
I
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
N
K
F
I
M
A
L
K
V
L
F
K
-
S
Q
L
E
-
K
-
E
G
-
V
E
H
Q
L
R
R
E
I
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
-
G
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
L
---
R
---
R
---
R
-
M
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
-
H
D
-
E
-
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
----
P
S
H
T
E
T
H
R
R
I
--
V
N
---
V
D
----
L
K
F
--
P
----
P
F
--
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
--
R
-----
L
-----
P
L
K
-
G
V
M
E
H
P
W
V
-
K
A
N
S
R
R
-----------------
166
Blastp_CBE
69.55
100%
-152
- C1 -
-
3W2C
8.4
-
AURKA_HUMAN
C:
[1-261]
-------------------------------------------------------------------------------------------------------------------------------
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
---------------
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
-----------
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
------------------------------------------
T
L
D
Y
L
P
P
E
M
I
E
----------
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
--
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
------------------------
H
P
W
I
-
T
A
N
S
S
------------------
208
Blastp_CBE
69.51
70%
-88
- C1 -
-
4B8M
7.2
-
AUKBA_XENLA
A:
[11-273]
------------------------------------------------------------------------------------------------------------------------------
K
F
T
I
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
N
K
F
I
M
A
L
K
V
L
F
K
-
S
Q
L
E
-
K
-
E
G
-
V
E
H
Q
L
R
R
E
I
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
-
G
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
L
---
R
---
R
---
R
-
M
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
-
H
D
-
E
-
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
----
P
S
H
T
E
T
H
R
R
I
--
V
N
---
V
D
----
L
K
F
--
P
----
P
F
--
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
--
R
-----
L
-----
P
L
K
-
G
V
M
E
H
P
W
V
-
K
A
N
S
R
R
-----------------
207
Blastp_CBE
69.26
70%
-86
- C1 -
-
4B8M
8.1
-
AUKBA_XENLA
B:
[6-273]
-------------------------------------------------------------------------------------------------------------------------
E
M
P
K
R
K
F
T
I
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
N
K
F
I
M
A
L
K
V
L
F
K
-
S
Q
L
E
-
K
-
E
G
-
V
E
H
Q
L
R
R
E
I
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
-
G
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
L
---
R
---
R
---
R
-
M
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
-
H
D
-
E
-
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
----
P
S
H
T
E
T
H
R
R
I
--
V
N
---
V
D
----
L
K
F
--
P
----
P
F
--
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
--
R
-----
L
-----
P
L
K
-
G
V
M
E
H
P
W
V
-
K
A
N
S
R
R
-----------------
204
Blastp_CBE
69.26
70%
-84
- C1 -
-
2VGO
7.1
-
AUKBA_XENLA
A:
[10-272]
------------------------------------------------------------------------------------------------------------------------------
K
F
T
I
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
N
K
F
I
M
A
L
K
V
L
F
K
-
S
Q
L
E
-
K
-
E
G
-
V
E
H
Q
L
R
R
E
I
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
-
G
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
L
---
R
---
R
---
R
-
M
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
-
H
D
-
E
-
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
----
P
S
H
T
E
T
H
R
R
I
--
V
N
---
V
D
----
L
K
F
--
P
----
P
F
--
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
--
R
-----
L
-----
P
L
K
-
G
V
M
E
H
P
W
V
-
K
A
N
S
R
R
-----------------
210
Blastp_CBE
69.20
70%
-85
- C1 -
-
4C2V
8.9
-
AUKBA_XENLA
A:
[12-274]
------------------------------------------------------------------------------------------------------------------------------
K
F
T
I
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
N
K
F
I
M
A
L
K
V
L
F
K
-
S
Q
L
E
-
K
-
E
G
-
V
E
H
Q
L
R
R
E
I
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
-
G
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
L
---
R
---
R
---
R
-
M
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
-
H
D
-
E
-
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
----
P
S
H
T
E
T
H
R
R
I
--
V
N
---
V
D
----
L
K
F
--
P
----
P
F
--
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
--
R
-----
L
-----
P
L
K
-
G
V
M
E
H
P
W
V
-
K
A
N
S
R
R
-----------------
215
Blastp_CBE
69.10
69%
-84
- C1 -
-
5EYK
9.2
-
AUKBA_XENLA
B:
[2-269]
-------------------------------------------------------------------------------------------------------------------------
E
M
P
K
R
K
F
T
I
D
D
F
D
I
V
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
N
K
F
I
M
A
L
K
V
L
F
K
-
S
Q
L
E
-
K
-
E
G
-
V
E
H
Q
L
R
R
E
I
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
-
G
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
L
---
R
---
R
---
R
-
M
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
-
H
D
-
E
-
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
----
P
S
H
T
E
T
H
R
R
I
--
V
N
---
V
D
----
L
K
F
--
P
----
P
F
--
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
--
R
-----
L
-----
P
L
K
-
G
V
M
E
H
P
W
V
-
K
A
N
S
R
R
-----------------
167
Blastp_CBE
68.95
100%
-149
- C1 -
-
3W2C
8.7
-
AURKA_HUMAN
A:
[1-261]
-------------------------------------------------------------------------------------------------------------------------------
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
---------------
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
----------
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
------------------------------------------
T
L
D
Y
L
P
P
E
M
I
E
----------
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
--
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
------------------------
H
P
W
I
-
T
A
N
S
S
------------------
200
Blastp_CBE
68.90
70%
-84
- C1 -
-
3ZTX
8.2
-
AUKBA_XENLA
A:
[10-272]
------------------------------------------------------------------------------------------------------------------------------
K
F
T
I
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
N
K
F
I
M
A
L
K
V
L
F
K
-
S
Q
L
E
-
K
-
E
G
-
V
E
H
Q
L
R
R
E
I
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
-
G
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
L
---
R
---
R
---
R
-
M
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
-
H
D
-
E
-
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
----
P
S
H
T
E
T
H
R
R
I
--
V
N
---
V
D
----
L
K
F
--
P
----
P
F
--
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
--
R
-----
L
-----
P
L
K
-
G
V
M
E
H
P
W
V
-
K
A
N
S
R
R
-----------------
211
Blastp_CBE
68.78
70%
-87
- C1 -
-
4C2W
5.1
-
AUKBA_XENLA
B:
[5-272]
-------------------------------------------------------------------------------------------------------------------------
E
M
P
K
R
K
F
T
I
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
N
K
F
I
M
A
L
K
V
L
F
K
-
S
Q
L
E
-
K
-
E
G
-
V
E
H
Q
L
R
R
E
I
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
-
G
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
L
---
R
---
R
---
R
-
M
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
-
H
D
-
E
-
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
----
P
S
H
T
E
T
H
R
R
I
--
V
N
---
V
D
----
L
K
F
--
P
----
P
F
--
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
--
R
-----
L
-----
P
L
K
-
G
V
M
E
H
P
W
V
-
K
A
N
S
R
R
-----------------
164
Blastp_CBE
68.46
100%
-142
- C1 -
-
3W2C
8.7
-
AURKA_HUMAN
G:
[1-261]
-------------------------------------------------------------------------------------------------------------------------------
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
---------------
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
-----------
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
------------------------------------------
T
L
D
Y
L
P
P
E
M
I
E
----------
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
----
N
T
Y
Q
--
Y
K
R
I
--
S
R
---
V
E
----
F
T
F
--
P
----
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
------------------------
H
P
W
I
-
T
A
N
S
S
------------------
202
Blastp_CBE
67.99
70%
-87
- C1 -
-
2VGP
5.6
-
AUKBA_XENLA
A:
[11-272]
-------------------------------------------------------------------------------------------------------------------------------
F
T
I
D
D
F
D
I
G
R
P
L
G
K
---
G
N
V
Y
L
A
-
R
E
---
K
---
Q
N
K
F
I
M
A
L
K
V
L
F
K
-
S
Q
L
E
-
K
-
E
G
-
V
E
H
Q
L
R
R
E
I
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
-
G
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
L
---
R
---
R
---
R
-
M
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
-
H
D
-
E
-
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
----
P
S
H
T
E
T
H
R
R
I
--
V
N
---
V
D
----
L
K
F
--
P
----
P
F
--
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
--
R
-----
L
-----
P
L
K
-
G
V
M
E
H
P
W
V
-
K
A
N
S
R
R
-----------------
214
Blastp_CBE
67.95
69%
-82
- C1 -
-
2BFY
8.5
-
AUKBA_XENLA
A:
[9-272]
-----------------------------------------------------------------------------------------------------------------------------
R
K
F
T
I
D
D
F
D
I
V
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
N
K
F
I
M
A
L
K
V
L
F
K
-
S
Q
L
E
-
K
-
E
G
-
V
E
H
Q
L
R
R
E
I
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
-
G
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
L
---
R
---
R
---
R
-
M
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
-
H
D
-
E
-
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
----
P
S
H
T
E
T
H
R
R
I
--
V
N
---
V
D
----
L
K
F
--
P
----
P
F
--
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
--
R
-----
L
-----
P
L
K
-
G
V
M
E
H
P
W
V
-
K
A
N
S
R
R
-----------------
212
Blastp_CBE
67.83
70%
-84
- C1 -
-
4C2W
5.6
-
AUKBA_XENLA
A:
[11-272]
-------------------------------------------------------------------------------------------------------------------------------
F
T
I
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
N
K
F
I
M
A
L
K
V
L
F
K
-
S
Q
L
E
-
K
-
E
G
-
V
E
H
Q
L
R
R
E
I
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
-
G
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
L
---
R
---
R
---
R
-
M
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
-
H
D
-
E
-
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
----
P
S
H
T
E
T
H
R
R
I
--
V
N
---
V
D
----
L
K
F
--
P
----
P
F
--
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
--
R
-----
L
-----
P
L
K
-
G
V
M
E
H
P
W
V
-
K
A
N
S
R
R
-----------------
205
Blastp_CBE
67.66
70%
-84
- C1 -
-
2VRX
7.5
-
AUKBA_XENLA
B:
[6-273]
-------------------------------------------------------------------------------------------------------------------------
E
M
P
K
R
K
F
T
I
D
D
F
D
I
G
R
P
L
G
----
G
N
V
Y
L
A
-
R
E
---
K
---
Q
N
K
F
I
M
A
L
K
V
L
F
K
-
S
Q
L
E
-
K
-
E
G
-
V
E
H
Q
L
R
R
E
I
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
-
G
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
L
---
R
---
R
---
R
-
M
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
-
H
D
-
E
-
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
----
P
S
H
T
E
T
H
R
R
I
--
V
N
---
V
D
----
L
K
F
--
P
----
P
F
--
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
--
R
-----
L
-----
P
L
K
-
G
V
M
E
H
P
W
V
-
K
A
N
S
R
R
-----------------
199
Blastp_CBE
67.45
70%
-83
- C1 -
-
3ZTX
7.6
-
AUKBA_XENLA
B:
[5-272]
-------------------------------------------------------------------------------------------------------------------------
E
M
P
K
R
K
F
T
I
D
D
F
D
I
G
R
P
L
-----
G
N
V
Y
L
A
-
R
E
---
K
---
Q
N
K
F
I
M
A
L
K
V
L
F
K
-
S
Q
L
E
-
K
-
E
G
-
V
E
H
Q
L
R
R
E
I
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
-
G
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
L
---
R
---
R
---
R
-
M
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
-
H
D
-
E
-
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
----
P
S
H
T
E
T
H
R
R
I
--
V
N
---
V
D
----
L
K
F
--
P
----
P
F
--
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
--
R
-----
L
-----
P
L
K
-
G
V
M
E
H
P
W
V
-
K
A
N
S
R
R
-----------------
213
Blastp_CBE
67.42
69%
-77
- C1 -
-
2BFY
8.7
-
AUKBA_XENLA
B:
[5-272]
-------------------------------------------------------------------------------------------------------------------------
E
M
P
K
R
K
F
T
I
D
D
F
D
I
V
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
N
K
F
I
M
A
L
K
V
L
F
K
-
S
Q
L
E
-
K
-
E
G
-
V
E
H
Q
L
R
R
E
I
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
-
G
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
L
---
R
---
R
---
R
-
M
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
-
H
D
-
E
-
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
----
P
S
H
T
E
T
H
R
R
I
--
V
N
---
V
D
----
L
K
F
--
P
----
P
F
--
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
--
R
-----
L
-----
P
L
K
-
G
V
M
E
H
P
W
V
-
K
A
N
S
R
R
-----------------
203
Blastp_CBE
66.50
70%
-84
- C1 -
-
2VGO
6.4
-
AUKBA_XENLA
B:
[5-272]
-------------------------------------------------------------------------------------------------------------------------
E
M
P
K
R
K
F
T
I
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
N
K
F
I
M
A
L
K
V
L
F
K
-
S
Q
L
E
-
K
----
V
E
H
Q
L
R
R
E
I
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
-
G
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
L
---
R
---
R
---
R
-
M
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
-
H
D
-
E
-
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
----
P
S
H
T
E
T
H
R
R
I
--
V
N
---
V
D
----
L
K
F
--
P
----
P
F
--
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
--
R
-----
L
-----
P
L
K
-
G
V
M
E
H
P
W
V
-
K
A
N
S
R
R
-----------------
551
HHSearch
62.49
34%
-37
- C1 -
-
4GV1
7.1
-
AKT1_HUMAN
A:
[6-278]
--------------------------------------------------------------------------------------------------------------------------------
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
-
K
E
---
K
---
A
T
G
R
Y
Y
A
M
K
I
L
K
K
-
E
V
I
V
-
A
-
K
D
-
E
V
A
H
T
L
T
E
N
R
--
V
L
Q
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
-
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
---
G
H
----
I
K
I
T
D
F
G
L
---
C
--
K
-
E
--
G
-
I
-
K
DG
A
---
T
---
M
K
--
T
-
F
----
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-
Y
G
-
R
-
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
----
Q
D
H
E
K
L
F
E
L
I
--
L
M
---
E
E
----
I
R
F
--
P
----
R
T
--
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
-----
L
GGGSE
D
A
K
-
E
I
M
Q
H
R
F
F
-
A
G
I
V
W
------------------
561
HHSearch
61.78
32%
-68
- C1 -
-
6ED6
7.9
-
ROCK2_HUMAN
A:
[84-363]
------------------------------------------------------------------------------------------------------------------------------
Q
M
K
A
E
D
Y
D
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
-
R
H
---
K
---
A
S
Q
K
V
Y
A
M
K
L
L
S
K
-
F
E
M
I
-
K
-
R
S
-
D
S
A
F
F
W
E
E
R
D
--
I
M
A
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
--
D
-
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
L
I
H
R
D
V
K
P
D
N
M
L
L
D
K
H
---
G
H
----
L
K
L
A
D
F
G
T
---
C
--
M
-
K
--
M
-
D
-
E
--
T
---
G
MVH
C
D
--
T
-
A
----
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
-F
Y
G
-
R
-
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
----
D
S
L
V
G
T
Y
S
K
I
--
M
D
---
H
K
NSLC
F
P
E
--
D
----
A
E
--
I
S
K
H
A
K
N
L
I
C
A
F
L
T
D
R
E
V
R
LG
R
-----
N
-----
G
V
E
-
E
I
R
Q
H
P
F
F
-
K
N
D
Q
-------------------
560
HHSearch
61.65
30%
-103
- C1 -
-
5TVT
7.9
-
MELK_HUMAN
A:
[8-269]
--------------------------------------------------------------------------------------------------------------------------------
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
-
C
H
---
I
---
L
T
G
E
M
V
A
I
K
I
M
D
K
-
N
T
L
G
----
S
-
D
L
P
R
I
K
T
E
I
E
--
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
-
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
---
H
K
----
L
K
L
I
D
F
G
L
---
C
--
A
-
K
-----------------------------
G
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
G
-
S
-
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
----
D
N
V
M
A
L
Y
K
K
I
--
M
R
---
G
K
----
Y
D
V
--
P
----
K
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
--
R
-----
I
-----
S
M
K
-
N
L
L
N
H
P
W
I
-
M
Q
D
Y
N
------------------
456
Blastp_CBE
61.39
37%
-75
- C1 -
-
4YZB
6.9
-
?
A:
[36-455]
----------------------------------------------------------------------------------------------------------------------------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
---
K
---
V
T
G
Q
E
Y
A
V
K
V
I
S
K
-
R
----
Q
-
K
T
-
D
K
E
L
L
L
K
E
V
E
--
L
L
K
K
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
N
K
RKD
A
N
----
I
R
I
I
D
F
G
L
---
S
--
T
-
H
--
F
-
E
-
S
--
T
---
K
---
K
M
K-
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
-
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
----
A
N
E
F
D
I
L
K
K
V
--
E
K
---
G
K
----
F
T
F
DL
P
----
Q
W
KK
V
S
E
P
A
K
D
L
I
R
K
M
L
A
Y
V
P
T
M
--
R
-----
I
-----
S
A
R
-
D
A
L
E
H
E
W
L
K
T
T
D
A
A
T
---
D
S
------------
455
Blastp_CBE
60.67
37%
-75
- C1 -
-
4YZB
6.6
-
?
B:
[36-471]
----------------------------------------------------------------------------------------------------------------------------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
---
K
---
V
T
G
Q
E
Y
A
V
K
V
I
S
K
-
R
----
Q
-
K
T
-
D
K
E
L
L
L
K
E
V
E
--
L
L
K
K
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
N
K
RKD
A
N
----
I
R
I
I
D
F
G
L
---
S
--
T
-
H
--
F
-
E
-
S
--
T
---
K
---
K
M
K-
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
-
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
----
A
N
E
F
D
I
L
K
K
V
--
E
K
---
G
K
----
F
T
F
DL
P
----
Q
W
KK
V
S
E
P
A
K
D
L
I
R
K
M
L
A
Y
V
P
T
M
--
R
-----
I
-----
S
A
R
-
D
A
L
E
H
E
W
L
K
T
T
D
A
A
T
---
D
S
------------
368
Blastp_CBE
60.05
37%
-83
- C1 -
-
2BIY
5.0
-
PDPK1_HUMAN
A:
[30-274]
----------------------------------------------------------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
-
R
E
---
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
-
R
H
I
I
-
K
-
E
N
-
K
V
P
Y
V
T
R
E
R
D
--
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
---
M
H
----
I
Q
I
T
D
F
G
T
---
A
K-
V
-
L
--
S
-
P
-
E
--
S
KQA
R
---
A
N
--
A
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
-
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
----
G
N
E
Y
L
I
F
Q
K
I
--
I
K
---
L
E
----
Y
D
F
--
P
----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
-----------------------------------------------
477
Blastp_CBE
59.45
34%
-42
- C1 -
-
5N23
6.5
-
KAPCA_HUMAN
A:
[41-309]
---------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
R
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
---
K
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
-
Q
K
V
V
-
K
-
L
K
Q
I
E
H
T
L
N
-
E
K
R
--
I
Q
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
---
G
Y
----
I
K
V
A
D
F
G
F
---
A
--
K
-
R
--
V
---
K
--
G
---
R
---
T
P
--
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-
Y
N
-
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
----
D
Q
P
I
Q
I
Y
E
K
I
--
V
S
---
G
K
----
V
R
F
--
P
----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
FGNLK
N
-----
G
V
N
-
D
I
K
N
H
K
W
F
-
A
T
T
D
-------------------
234
Blastp_CBE
59.43
38%
-87
- C1 -
-
4IEB
4.6
-
?
A:
[55-309]
----------------------------------------------------------------------------------------------------------------------------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
---
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
-
R
Q
V
-----
T
-
D
K
E
S
L
L
R
E
V
Q
--
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
M
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
---
S
K
DAN-
I
R
I
I
D
F
G
L
---
S
--
T
-
H
--
F
-
E
-
A
--
S
---
K
---
K
M
K-
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
-
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
----
A
N
E
Y
D
I
L
K
K
V
--
E
K
---
G
K
----
Y
T
F
E-
P
----
Q
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
--
R
-----
I
-----
S
A
R
-
D
A
L
D
H
E
W
I
------------------------
317
Blastp_CBE
59.16
37%
-133
- C1 -
-
5HO8
5.9
-
PDPK1_HUMAN
A:
[30-274]
----------------------------------------------------------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
-
R
E
---
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
-
R
H
I
I
-
K
-
E
N
-
K
V
P
Y
V
T
R
E
R
D
--
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
---
M
H
----
I
Q
I
T
D
F
G
T
---
A
K-
V
-
L
--
S
------------------
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
-
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
----
G
N
E
Y
L
I
F
Q
K
I
--
I
K
---
L
E
----
Y
D
F
--
P
----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
-----------------------------------------------
228
Blastp_CBE
59.14
36%
-57
- C1 -
-
4CZU
4.9
-
CIPKN_ARATH
D:
[13-279]
------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
-
R
N
---
V
---
E
N
G
D
N
V
A
I
K
V
I
D
K
-
E
K
V
L
-
K
-
N
K
-
M
I
A
Q
I
K
R
E
I
S
--
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
-
G
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
-
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
A
N
---
G
A
----
L
K
V
S
D
F
G
L
---
S
--
A
-
L
--
P
-
Q
-
Q
--
V
---
R
---
E
D
--
G
-
L
LHDT
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
-
Y
D
G
A
-
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
----
S
N
L
T
S
L
Y
K
K
I
--
F
K
---
A
E
----
F
T
C
--
P
----
P
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
--
R
-----
I
-----
T
F
A
-
E
V
I
E
N
E
W
F
-
K
K
G
Y
K
A
---
P
-------------
312
Blastp_CBE
58.96
37%
-84
- C1 -
-
1OKY
8.8
-
PDPK1_HUMAN
A:
[30-274]
----------------------------------------------------------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
-
R
E
---
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
-
R
H
I
I
-
K
-
E
N
-
K
V
P
Y
V
T
R
E
R
D
--
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
---
M
H
----
I
Q
I
T
D
F
G
T
---
A
K-
V
-
L
--
S
-
P
-
E
--
S
-----------
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
-
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
----
G
N
E
Y
L
I
F
Q
K
I
--
I
K
---
L
E
----
Y
D
F
--
P
----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
-----------------------------------------------
403
Blastp_CBE
58.93
33%
-93
- C1 -
-
5KZ7
7.6
-
MARK2_HUMAN
A:
[30-288]
-------------------------------------------------------------------------------------------------------------------------------
P
H
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
-
R
H
---
I
---
L
T
G
K
E
V
A
V
K
I
I
D
K
-
T
Q
L
N
-
S
-
S
S
-
L
Q
-
K
L
F
R
E
V
R
--
I
M
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
-
G
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
D
---
M
N
----
I
K
I
A
D
F
----------------------------------------
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
---
D
-
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
------
N
L
K
E
L
R
E
R
V
--
L
R
---
G
K
----
Y
R
I
--
P
----
F
Y
--
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
--
R
-----
G
-----
T
L
E
-
Q
I
M
K
D
R
W
M
-
N
V
---------------------
307
Blastp_CBE
58.79
37%
-90
- C1 -
-
3IOP
7.9
-
PDPK1_HUMAN
A:
[33-277]
----------------------------------------------------------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
-
R
E
---
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
-
R
H
I
I
-
K
-
E
N
-
K
V
P
Y
V
T
R
E
R
D
--
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
---
M
H
----
I
Q
I
T
D
F
G
T
---
A
K-
V
-
L
--
S
------------------
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
-
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
----
G
N
E
Y
L
I
F
Q
K
I
--
I
K
---
L
E
----
Y
D
F
--
P
----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
-----------------------------------------------
311
Blastp_CBE
58.57
37%
-87
- C1 -
-
1OKZ
2.5
-
PDPK1_HUMAN
A:
[30-274]
----------------------------------------------------------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
-
R
E
---
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
-
R
H
I
I
-
K
-
E
N
-
K
V
P
Y
V
T
R
E
R
D
--
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
---
M
H
----
I
Q
I
T
D
F
G
T
---
A
K-
V
-
L
--
S
------------------
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
-
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
----
G
N
E
Y
L
I
F
Q
K
I
--
I
K
---
L
E
----
Y
D
F
--
P
----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
-----------------------------------------------
278
Blastp_CBE
58.57
34%
-81
- C1 -
-
5ES1
8.8
-
MARK4_HUMAN
A:
[16-268]
-----------------------------------------------------------------------------------------------------------------------------------
N
Y
R
L
L
R
T
I
G
K
G
N
F
A
K
V
K
L
A
-
R
H
---
I
---
L
T
G
R
E
V
A
I
K
I
I
D
K
-
T
Q
L
N
-
P
-
S
S
-
L
Q
-
K
L
F
R
E
V
R
--
I
M
K
G
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
A
G
E
V
F
D
Y
L
V
S
H
-
G
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
H
Y
C
H
Q
-
K
N
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
E
---
A
N
----
I
K
I
A
D
F
G
F
---
S
N----------------------------------
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
-
Y
D
-
G
P
E
V
D
I
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
----
H
N
L
K
E
L
R
E
R
V
--
L
R
---
G
K
----
Y
R
V
--
P
----
F
Y
--
M
S
T
D
C
E
S
I
L
R
R
F
L
V
L
N
P
A
K
--
R
-----
C
-----
T
L
E
-
Q
I
M
K
D
K
W
I
------------------------
457
Blastp_CBE
58.44
37%
-62
- C1 -
-
4YUQ
5.8
-
?
B:
[36-301]
----------------------------------------------------------------------------------------------------------------------------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
---
K
---
V
T
G
Q
E
Y
A
V
K
V
I
S
K
-
R
Q
------------
L
L
K
E
V
E
--
L
L
K
K
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
N
K
RKD
A
N
----
I
R
I
I
D
F
G
L
---
S
--
T
-
H
--
F
-
E
-
S
--
T
---
K
---
K
M
K-
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
-
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
----
A
N
E
F
D
I
L
K
K
V
--
E
K
---
G
K
----
F
T
F
DL
P
----
Q
W
KK
V
S
E
P
A
K
D
L
I
R
K
M
L
A
Y
V
P
T
M
--
R
-----
I
-----
S
A
R
-
D
A
L
E
H
E
W
L
K
T
T
D
A
A
T
---
D
S
------------
299
Blastp_CBE
58.40
37%
-86
- C1 -
-
3RWP
7.6
-
PDPK1_HUMAN
A:
[32-276]
----------------------------------------------------------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
-
R
E
---
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
-
R
H
I
I
-
K
-
E
N
-
K
V
P
Y
V
T
R
E
R
D
--
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
---
M
H
----
I
Q
I
T
D
F
G
T
---
A
K-
V
-
L
--
S
------------------
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
-
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
----
G
N
E
Y
L
I
F
Q
K
I
--
I
K
---
L
E
----
Y
D
F
--
P
----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
-----------------------------------------------
461
Blastp_CBE
58.23
37%
-72
- C1 -
-
4YSJ
6.0
-
?
B:
[36-455]
----------------------------------------------------------------------------------------------------------------------------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
---
K
---
V
T
G
Q
E
Y
A
V
K
V
I
S
K
-
R
-------------
L
L
K
E
V
E
--
L
L
K
K
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
N
K
RKD
A
N
----
I
R
I
I
D
F
G
L
---
S
--
T
-
H
--
F
-
E
-
S
--
T
---
K
---
K
M
K-
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
-
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
----
A
N
E
F
D
I
L
K
K
V
--
E
K
---
G
K
----
F
T
F
DL
P
----
Q
W
KK
V
S
E
P
A
K
D
L
I
R
K
M
L
A
Y
V
P
T
M
--
R
-----
I
-----
S
A
R
-
D
A
L
E
H
E
W
L
K
T
T
D
A
A
T
---
D
S
------------
363
Blastp_CBE
58.18
37%
-87
- C1 -
-
3ION
8.5
-
PDPK1_HUMAN
A:
[33-277]
----------------------------------------------------------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
-
R
E
---
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
-
R
H
I
I
-
K
-
E
N
-
K
V
P
Y
V
T
R
E
R
D
--
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
---
M
H
----
I
Q
I
T
D
F
G
T
---
A
K-
V
-
L
--
S
-------------------------
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
-
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
----
G
N
E
Y
L
I
F
Q
K
I
--
I
K
---
L
E
----
Y
D
F
--
P
----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
-----------------------------------------------
462
Blastp_CBE
58.16
37%
-72
- C1 -
-
4YSJ
6.1
-
?
A:
[36-303]
----------------------------------------------------------------------------------------------------------------------------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
---
K
---
V
T
G
Q
E
Y
A
V
K
V
I
S
K
-
R
-------------
L
L
K
E
V
E
--
L
L
K
K
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
N
K
RKD
A
N
----
I
R
I
I
D
F
G
L
---
S
--
T
-
H
--
F
-
E
-
S
--
T
---
K
---
K
M
K-
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
-
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
----
A
N
E
F
D
I
L
K
K
V
--
E
K
---
G
K
----
F
T
F
DL
P
----
Q
W
KK
V
S
E
P
A
K
D
L
I
R
K
M
L
A
Y
V
P
T
M
--
R
-----
I
-----
S
A
R
-
D
A
L
E
H
E
W
L
K
T
T
D
A
A
T
---
D
S
------------
303
Blastp_CBE
58.12
37%
-82
- C1 -
-
3QCY
7.2
-
PDPK1_HUMAN
A:
[33-277]
----------------------------------------------------------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
-
R
E
---
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
-
R
H
I
I
-
K
-
E
N
-
K
V
P
Y
V
T
R
E
R
D
--
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
---
M
H
----
I
Q
I
T
D
F
G
T
---
A
K-
V
-
L
--
S
-------------------------
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
-
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
----
G
N
E
Y
L
I
F
Q
K
I
--
I
K
---
L
E
----
Y
D
F
--
P
----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
-----------------------------------------------
337
Blastp_CBE
58.06
37%
-90
- C1 -
-
5LVP
4.9
-
PDPK1_HUMAN
C:
[32-276]
----------------------------------------------------------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
-
R
E
---
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
-
R
H
I
I
-
K
-
E
N
-
K
V
P
Y
V
T
R
E
R
D
--
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
---
M
H
----
I
Q
I
T
D
F
G
T
---
A
K-
V
-
L
--
S
------------------
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
-
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
----
G
N
E
G
L
I
F
A
K
I
--
I
K
---
L
E
----
Y
D
F
--
P
----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
-----------------------------------------------
291
Blastp_CBE
57.93
37%
-86
- C1 -
-
2PE0
2.3
-
PDPK1_HUMAN
A:
[7-251]
----------------------------------------------------------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
-
R
E
---
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
-
R
H
I
I
-
K
-
E
N
-
K
V
P
Y
V
T
R
E
R
D
--
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
---
M
H
----
I
Q
I
T
D
F
G
T
---
A
K-
V
-
L
--
S
--------------------
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
-
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
----
G
N
E
Y
L
I
F
Q
K
I
--
I
K
---
L
E
----
Y
D
F
--
P
----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
-----------------------------------------------
290
Blastp_CBE
57.93
37%
-83
- C1 -
-
2PE1
5.8
-
PDPK1_HUMAN
A:
[7-251]
----------------------------------------------------------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
-
R
E
---
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
-
R
H
I
I
-
K
-
E
N
-
K
V
P
Y
V
T
R
E
R
D
--
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
---
M
H
----
I
Q
I
T
D
F
G
T
---
A
K-
V
-
L
--
S
--------------------
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
-
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
----
G
N
E
Y
L
I
F
Q
K
I
--
I
K
---
L
E
----
Y
D
F
--
P
----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
-----------------------------------------------
336
Blastp_CBE
57.84
37%
-134
- C1 -
-
5LVP
4.6
-
PDPK1_HUMAN
D:
[32-276]
----------------------------------------------------------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
-
R
E
---
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
-
R
H
I
I
-
K
-
E
N
-
K
V
P
Y
V
T
R
E
R
D
--
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
---
M
H
----
I
Q
I
T
D
F
G
T
---
A
K-
V
-
L
--
S
--------------------
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
-
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
----
G
N
E
G
L
I
F
A
K
I
--
I
K
---
L
E
----
Y
D
F
--
P
----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
-----------------------------------------------
267
Blastp_CBE
57.85
38%
-80
- C1 -
-
3HX4
4.2
-
?
A:
[56-309]
----------------------------------------------------------------------------------------------------------------------------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
---
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
-----------
D
K
E
S
L
L
R
E
V
Q
--
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
---
S
K
DAN-
I
R
I
I
D
F
G
L
---
S
--
T
-
H
--
F
-
E
-
A
--
S
---
K
---
K
M
K-
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
-
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
----
A
N
E
Y
D
I
L
K
K
V
--
E
K
---
G
K
----
Y
T
F
EL
P
----
Q
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
--
R
-----
I
-----
S
A
R
-
D
A
L
D
H
E
W
I
------------------------
255
Blastp_CBE
57.84
38%
-71
- C1 -
-
3UPX
6.2
-
?
A:
[32-304]
----------------------------------------------------------------------------------------------------------------------------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
---
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
-
R
Q
V
K
-
Q
-
K
T
-
D
K
E
S
L
L
R
E
V
Q
--
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
---
S
K
DAN-
I
R
I
I
D
F
G
L
---
S
--
T
-
H
--
F
-
E
-
A
--
S
---
K
---
K
M
K-
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
-
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
----
A
N
E
Y
D
I
L
K
K
V
--
E
K
---
G
K
----
Y
T
F
EL
P
----
Q
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
--
R
-----
I
-----
S
A
R
-
D
A
L
D
H
E
W
I
------------------------
401
Blastp_CBE
57.78
33%
-86
- C1 -
-
5KZ8
7.5
-
MARK2_HUMAN
A:
[30-288]
-------------------------------------------------------------------------------------------------------------------------------
P
H
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
-
R
H
---
I
---
L
T
G
K
E
V
A
V
K
I
I
D
K
-
T
Q
L
N
-
S
-
S
S
-
L
Q
-
K
L
F
R
E
V
R
--
I
M
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
-
G
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
D
---
M
N
----
I
K
I
A
D
F
G
--------------------------------------
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
-
Y
D
-
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
----
Q
N
L
K
E
L
R
E
R
V
--
L
R
---
G
K
----
Y
R
I
--
P
----
F
Y
--
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
--
R
-----
G
-----
T
L
E
-
Q
I
M
K
D
R
W
M
-
N
V
---------------------
283
Blastp_CBE
57.76
37%
-81
- C1 -
-
1UU9
3.2
-
PDPK1_HUMAN
A:
[9-253]
----------------------------------------------------------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
-
R
E
---
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
-
R
H
I
I
-
K
-
E
N
-
K
V
P
Y
V
T
R
E
R
D
--
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
---
M
H
----
I
Q
I
T
D
F
G
T
---
A
K-
V
-
L
--
S
------------------
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
-
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
----
G
N
E
Y
L
I
F
Q
K
I
--
I
K
---
L
E
----
Y
D
F
--
P
----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
-----------------------------------------------
390
Blastp_CBE
57.75
33%
-78
- C1 -
-
5EAK
8.1
-
MARK2_HUMAN
B:
[15-271]
----------------------------------------------------------------------------------------------------------------------------------
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
-
R
H
---
I
---
L
T
G
K
E
V
A
V
K
I
I
D
K
-
T
Q
L
N
-
S
-
S
S
-
L
Q
-
K
L
F
R
E
V
R
--
I
M
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
-
G
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
D
---
M
N
----
I
K
I
A
D
F
G
---------------------------------
F
----
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
-
Y
D
-
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
----
Q
N
L
K
E
L
R
E
R
V
--
L
R
---
G
K
----
Y
R
I
--
P
----
F
Y
--
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
--
R
-----
G
-----
T
L
E
-
Q
I
M
K
D
R
W
M
-
N
V
G
--------------------
272
Blastp_CBE
57.69
38%
-67
- C1 -
-
5T6K
3.8
-
?
A:
[73-357]
----------------------------------------------------------------------------------------------------------------------------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
---
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
-
R
Q
V
K
-
Q
-
K
T
-
D
K
E
S
L
L
R
E
V
Q
--
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
---
S
K
DAN-
I
R
I
I
D
F
G
L
---
S
--
T
-
H
--
F
-
E
-
A
------
K
---
K
M
K-
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
-
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
----
A
N
E
Y
D
I
L
K
K
V
--
E
K
---
G
K
----
Y
T
F
EL
P
----
Q
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
--
R
-----
I
-----
S
A
R
-
D
A
L
D
H
E
W
I
------------------------
298
Blastp_CBE
57.67
35%
-48
- C1 -
-
6FDY
6.7
-
ULK3_HUMAN
U:
[10-269]
---------------------------------------------------------------------------------------------------------------------------------
L
D
G
F
I
L
T
E
R
L
G
-----
T
V
Y
K
A
Y
A
K
---
K
---
D
T
R
E
V
V
A
I
K
C
V
A
K
-
K
S
L
N
-
K
-
A
S
-
V
E
N
L
L
T
-
E
I
E
--
I
L
K
G
I
R
H
P
H
I
V
Q
L
K
D
F
Q
W
D
S
D
N
I
Y
L
I
M
E
F
C
A
G
G
D
L
S
R
F
I
H
T
R
-
R
I
-
L
P
E
K
V
A
R
V
F
M
Q
Q
L
A
S
A
L
Q
F
L
H
E
-
R
N
I
S
H
L
D
L
K
P
Q
N
I
L
L
S
S
L
---
E
K
PH--
L
K
L
A
D
F
G
F
---
A
--
Q
-
H
M-
S
-
P
-
W
--
D
---
E
---
K
H
--
V
-
L
----
R
G
S
P
L
Y
M
A
P
E
M
V
C
Q
R
Q
-
Y
D
-
A
-
R
V
D
L
W
S
M
G
V
I
L
Y
E
A
L
F
G
Q
P
P
F
A
S
----
R
S
F
S
E
L
E
E
K
I
--
R
S
NRV
I
E
----
L
P
L
--
R
----
P
L
--
L
S
R
D
C
R
D
L
L
Q
R
L
L
E
R
D
P
S
R
--
R
-----
I
-----
S
F
Q
-
D
F
F
A
H
P
W
V
------------------------
274
Blastp_CBE
57.68
38%
-65
- C1 -
-
5T6A
5.8
-
?
A:
[73-357]
----------------------------------------------------------------------------------------------------------------------------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
---
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
-
R
Q
V
K
-
Q
-
K
T
-
D
K
E
S
L
L
R
E
V
Q
--
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
---
S
K
DAN-
I
R
I
I
D
F
G
L
---
S
--
T
-
H
--
F
-
E
-
A
------
K
---
K
M
K-
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
-
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
----
A
N
E
Y
D
I
L
K
K
V
--
E
K
---
G
K
----
Y
T
F
EL
P
----
Q
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
--
R
-----
I
-----
S
A
R
-
D
A
L
D
H
E
W
I
------------------------
248
Blastp_CBE
57.67
38%
-72
- C1 -
-
4ONA
4.4
-
?
A:
[32-285]
----------------------------------------------------------------------------------------------------------------------------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
---
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
-
R
Q
V
K
-
Q
-
K
T
-
D
K
E
S
L
L
R
E
V
Q
--
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
---
S
K
DAN-
I
R
I
I
D
F
G
L
---
S
--
T
-
H
--
F
-
E
-
A
--
S
---
K
---
K
M
K-
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
-
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
----
A
N
E
Y
D
I
L
K
K
V
--
E
K
---
G
K
----
Y
T
F
EL
P
----
Q
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
--
R
-----
I
-----
S
A
R
-
D
A
L
D
H
E
W
I
------------------------
320
Blastp_CBE
57.59
37%
-135
- C1 -
-
5HKM
7.1
-
PDPK1_HUMAN
A:
[30-274]
----------------------------------------------------------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
-
R
E
---
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
-
R
H
I
I
-
K
-
E
N
-
K
V
P
Y
V
T
R
E
R
D
--
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
---
M
H
----
I
Q
I
T
D
F
G
T
---
A
K-
V
-
L
--
S
--------------------
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
-
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
----
G
N
E
Y
L
I
F
Q
K
I
--
I
K
---
L
E
----
Y
D
F
--
P
----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
-----------------------------------------------
304
Blastp_CBE
57.57
37%
-86
- C1 -
-
3QCX
7.0
-
PDPK1_HUMAN
A:
[33-277]
----------------------------------------------------------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
-
R
E
---
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
-
R
H
I
I
-
K
-
E
N
-
K
V
P
Y
V
T
R
E
R
D
--
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
---
M
H
----
I
Q
I
T
D
F
G
T
---
A
K-
V
-
L
--
S
------------------
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
-
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
----
G
N
E
Y
L
I
F
Q
K
I
--
I
K
---
L
E
----
Y
D
F
--
P
----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
-----------------------------------------------
310
Blastp_CBE
57.56
37%
-87
- C1 -
-
1UU3
6.8
-
PDPK1_HUMAN
A:
[30-274]
----------------------------------------------------------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
-
R
E
---
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
-
R
H
I
I
-
K
-
E
N
-
K
V
P
Y
V
T
R
E
R
D
--
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
---
M
H
----
I
Q
I
T
D
F
G
T
---
A
K-
V
-
L
--
S
--------------------
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
-
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
----
G
N
E
Y
L
I
F
Q
K
I
--
I
K
---
L
E
----
Y
D
F
--
P
----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
-----------------------------------------------
305
Blastp_CBE
57.55
37%
-84
- C1 -
-
3QCS
5.9
-
PDPK1_HUMAN
A:
[33-277]
----------------------------------------------------------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
-
R
E
---
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
-
R
H
I
I
-
K
-
E
N
-
K
V
P
Y
V
T
R
E
R
D
--
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
---
M
H
----
I
Q
I
T
D
F
G
T
---
A
K-
V
-
L
--
S
------------------
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
-
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
----
G
N
E
Y
L
I
F
Q
K
I
--
I
K
---
L
E
----
Y
D
F
--
P
----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
-----------------------------------------------
251
Blastp_CBE
57.53
38%
-68
- C1 -
-
3V5T
5.8
-
?
A:
[32-290]
----------------------------------------------------------------------------------------------------------------------------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
---
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
-
R
Q
V
K
-
Q
-
K
T
-
D
K
E
S
L
L
R
E
V
Q
--
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
---
S
K
DAN-
I
R
I
I
D
F
G
L
---
S
--
T
-
H
--
F
-
E
-
A
--
S
---
K
---
K
M
K-
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
-
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
----
A
N
E
Y
D
I
L
K
K
V
--
E
K
---
G
K
----
Y
T
F
EL
P
----
Q
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
--
R
-----
I
-----
S
A
R
-
D
A
L
D
H
E
W
I
------------------------
557
HHSearch
57.52
34%
-61
- C1 -
-
4EJN
6.7
-
AKT1_HUMAN
A:
[145-414]
-------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
-
K
E
---
K
---
A
T
G
R
Y
Y
A
M
K
I
L
K
K
-
E
V
I
V
------------------
V
L
Q
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
-
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
---
G
H
----
I
K
I
T
D
F
G
L
---
C
--
K
-
E
--
G
-
I
-
K
-----------
K
--
T
-
F
----
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-
Y
G
-
R
-
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
----
Q
D
H
E
K
L
F
E
L
I
--
L
M
---
E
E
----
I
R
F
--
P
----
R
T
--
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
-----
L
GGGSE
D
A
K
-
E
I
M
Q
H
R
F
F
-
A
G
I
V
W
Q
-----------------
273
Blastp_CBE
57.51
38%
-66
- C1 -
-
5T6I
5.2
-
?
A:
[73-360]
----------------------------------------------------------------------------------------------------------------------------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
---
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
---
V
K
-
Q
-
K
T
-
D
K
E
S
L
L
R
E
V
Q
--
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
---
S
K
AN--
I
R
I
I
D
F
G
L
---
S
--
T
-
H
--
F
-
E
-
A
--
S
---
K
---
K
M
K-
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
-
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
----
A
N
E
Y
D
I
L
K
K
V
--
E
K
---
G
K
----
Y
T
F
EL
P
----
Q
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
--
R
-----
I
-----
S
A
R
-
D
A
L
D
H
E
W
I
------------------------
402
Blastp_CBE
57.50
33%
-91
- C1 -
-
5KZ7
7.0
-
MARK2_HUMAN
B:
[30-288]
-------------------------------------------------------------------------------------------------------------------------------
P
H
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
-
R
H
---
I
---
L
T
G
K
E
V
A
V
K
I
I
D
K
-
T
Q
L
N
-
S
-
S
S
-
L
Q
-
K
L
F
R
E
V
R
--
I
M
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
-
G
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
D
---
M
N
----
I
K
I
A
D
F
----------------------------------------
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
---
D
-
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
------
N
L
K
E
L
R
E
R
V
--
L
R
---
G
K
----
Y
R
I
--
P
----
F
Y
--
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
--
R
-----
G
-----
T
L
E
-
Q
I
M
K
D
R
W
M
-
N
V
---------------------
289
Blastp_CBE
57.30
37%
-85
- C1 -
-
2PE2
3.0
-
PDPK1_HUMAN
A:
[7-251]
----------------------------------------------------------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
-
R
E
---
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
-
R
H
I
I
-
K
-
E
N
-
K
V
P
Y
V
T
R
E
R
D
--
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
---
M
H
----
I
Q
I
T
D
F
G
T
---
A
K-
V
-
L
--
S
--------------------
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
-
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
----
G
N
E
Y
L
I
F
Q
K
I
--
I
K
---
L
E
----
Y
D
F
--
P
----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
-----------------------------------------------
451
Blastp_CBE
57.24
33%
-72
- C1 -
-
2RKU
3.0
-
PLK1_HUMAN
A:
[23-272]
------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
G
G
F
A
K
C
F
E
I
-
S
D
---
A
---
D
T
K
E
V
F
A
G
K
I
V
P
K
-
S
L
L
L
-
K
-
P
H
-
Q
R
E
K
M
S
M
E
I
S
--
I
H
R
S
L
A
H
Q
H
V
V
G
F
H
G
F
F
E
D
N
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
L
E
L
H
K
R
R
-
K
A
-
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
-
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
E
D
---
L
E
----
V
K
I
G
D
F
G
L
---
A
TK
V
-
E
--
Y
-
D
-
G
--
E
---
R
---
K
K
--
V
-
L
----
C
G
T
P
N
Y
I
A
P
E
V
L
S
K
K
G
-
H
S
-
F
-
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
E
T
----
S
C
L
K
E
T
Y
L
R
I
--
K
K
---
N
E
----
Y
S
I
--
P
----
K
H
--
I
N
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
--
R
-----
P
-----
T
I
N
-
E
L
L
N
D
E
F
F
-
T
S
G
--------------------
391
Blastp_CBE
57.22
33%
-73
- C1 -
-
5EAK
7.4
-
MARK2_HUMAN
A:
[11-271]
------------------------------------------------------------------------------------------------------------------------------
Q
P
H
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
-
R
H
---
I
---
L
T
G
K
E
V
A
V
K
I
I
D
K
-
T
Q
L
N
-
S
-
S
S
-
L
Q
-
K
L
F
R
E
V
R
--
I
M
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
-
G
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
D
---
M
N
----
I
K
I
A
D
F
G
F
---
S
----------------------------
F
----
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
-
Y
D
-
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
----
Q
N
L
K
E
L
R
E
R
V
--
L
R
---
G
K
----
Y
R
I
--
P
----
F
Y
--
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
--
R
-----
G
-----
T
L
E
-
Q
I
M
K
D
R
W
M
-
N
V
G
--------------------
236
Blastp_CBE
57.19
38%
-64
- C1 -
-
4MX9
6.8
-
?
A:
[33-292]
----------------------------------------------------------------------------------------------------------------------------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
---
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
-
R
Q
V
K
-
Q
-
K
T
-
D
K
E
S
L
L
R
E
V
Q
--
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
Y
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
---
S
K
DAN-
I
R
I
I
D
F
G
L
---
S
--
T
-
H
--
F
-
E
-
A
--
S
---
K
---
K
M
K-
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
-
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
----
A
N
E
Y
D
I
L
K
K
V
--
E
K
---
G
K
----
Y
T
F
EL
P
----
Q
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
--
R
-----
I
-----
S
A
R
-
D
A
L
D
H
E
W
I
------------------------
240
Blastp_CBE
57.11
38%
-69
- C1 -
-
5W91
5.6
-
?
A:
[32-299]
----------------------------------------------------------------------------------------------------------------------------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
---
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
-
R
Q
V
K
-
Q
-
K
T
-
D
K
E
S
L
L
R
E
V
Q
--
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
---
S
K
DAN-
I
R
I
I
D
F
G
L
---
S
--
T
-
H
--
F
-
E
-
A
--
S
---
K
---
K
M
K-
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
-
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
----
A
N
E
Y
D
I
L
K
K
V
--
E
K
---
G
K
----
Y
T
F
EL
P
----
Q
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
--
R
-----
I
-----
S
A
R
-
D
A
L
D
H
E
W
I
------------------------
306
Blastp_CBE
57.05
37%
-83
- C1 -
-
3QCQ
6.0
-
PDPK1_HUMAN
A:
[33-277]
----------------------------------------------------------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
-
R
E
---
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
-
R
H
I
I
-
K
-
E
N
-
K
V
P
Y
V
T
R
E
R
D
--
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
---
M
H
----
I
Q
I
T
D
F
G
T
---
A
K-
V
-
L
--
S
------------------
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
-
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
----
G
N
E
Y
L
I
F
Q
K
I
--
I
K
---
L
E
----
Y
D
F
--
P
----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
-----------------------------------------------
243
Blastp_CBE
57.02
38%
-66
- C1 -
-
4YJN
5.2
-
?
A:
[32-290]
----------------------------------------------------------------------------------------------------------------------------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
---
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
-
R
Q
V
K
-
Q
-
K
T
-
D
K
E
S
L
L
R
E
V
Q
--
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
---
S
K
DAN-
I
R
I
I
D
F
G
L
---
S
--
T
-
H
--
F
-
E
-
A
--
S
---
K
---
K
M
K-
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
-
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
----
A
N
E
Y
D
I
L
K
K
V
--
E
K
---
G
K
----
Y
T
F
EL
P
----
Q
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
--
R
-----
I
-----
S
A
R
-
D
A
L
D
H
E
W
I
------------------------
387
Blastp_CBE
57.01
35%
-64
- C1 -
-
4QOX
6.8
-
CDPK4_PLAF7
A:
[83-430]
----------------------------------------------------------------------------------------------------------------------------------------
K
I
L
G
K
G
S
F
G
E
V
I
L
S
-
R
D
---
K
---
H
T
G
H
E
Y
A
I
K
V
I
S
K
-
K
H
V
K
-
R
-
K
T
-
D
K
E
S
L
L
R
E
V
E
--
L
L
K
M
L
D
H
I
N
I
M
K
L
Y
E
F
F
E
D
N
N
Y
Y
Y
L
V
S
D
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
R
-
F
Y
E
I
D
A
A
R
I
I
K
Q
I
L
S
G
I
T
Y
M
H
K
-
N
N
V
V
H
R
D
L
K
P
E
N
I
L
L
E
T
K
---
N
-EDMI
I
K
I
I
D
F
G
L
---
S
--
T
-
H
--
F
-
E
-
Y
--
S
-------------
K
----
I
G
T
A
Y
Y
I
A
P
D
V
L
H
G
-
T
-
Y
D
-
E
-
K
C
D
I
W
S
C
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
----
S
N
E
Y
D
I
L
K
K
V
--
E
A
---
G
K
----
Y
T
F
DL
P
----
Q
F
KK
I
S
D
K
A
K
D
L
I
K
K
M
L
M
Y
T
S
A
V
--
R
-----
I
-----
S
A
R
-
D
A
L
E
H
E
W
I
-
K
M
M
T
S
K
---
D
N
------------
276
Blastp_CBE
56.98
38%
-66
- C1 -
-
5JMS
6.4
-
?
A:
[73-343]
----------------------------------------------------------------------------------------------------------------------------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
---
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
-
R
Q
V
K
-
Q
-
K
T
-
D
K
E
S
L
L
R
E
V
Q
--
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
---
S
K
DAN-
I
R
I
I
D
F
G
L
---
S
--
T
-
H
--
F
-
E
-
A
--
S
---
K
---
K
M
K-
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
-
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
----
A
N
E
Y
D
I
L
K
K
V
--
E
K
---
G
K
----
Y
T
F
EL
P
----
Q
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
--
R
-----
I
-----
S
A
R
-
D
A
L
D
H
E
W
I
------------------------
316
Blastp_CBE
56.96
37%
-80
- C1 -
-
3NUN
5.5
-
PDPK1_HUMAN
A:
[14-258]
----------------------------------------------------------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
-
R
E
---
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
-
R
H
I
I
-
K
-
E
N
-
K
V
P
Y
V
T
R
E
R
D
--
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
---
M
H
----
I
Q
I
T
D
F
G
T
---
A
K-
V
-
L
--
S
------------------
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
-
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
----
G
N
E
Y
L
I
F
Q
K
I
--
I
K
---
L
E
----
Y
D
F
--
P
----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
-----------------------------------------------
321
Blastp_CBE
56.80
37%
-80
- C1 -
-
2XCH
2.5
-
PDPK1_HUMAN
A:
[30-274]
----------------------------------------------------------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
-
R
E
---
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
-
R
H
I
I
-
K
-
E
N
-
K
V
P
Y
V
T
R
E
R
D
--
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
---
M
H
----
I
Q
I
T
D
F
G
T
---
A
K-
V
-
L
--
S
---------------
A
--
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
-
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
----
G
N
E
Y
L
I
F
Q
K
I
--
I
K
---
L
E
----
Y
D
F
--
P
----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
-----------------------------------------------
458
Blastp_CBE
56.73
37%
-63
- C1 -
-
4YUQ
5.9
-
?
A:
[36-301]
----------------------------------------------------------------------------------------------------------------------------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
---
K
---
V
T
G
Q
E
Y
A
V
K
V
I
S
K
-
R
Q
-----------
L
L
L
K
E
V
E
--
L
L
K
K
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
N
K
RKD
A
N
----
I
R
I
I
D
F
G
L
---
S
--
T
-
H
--
F
-
E
-
S
--
T
---
K
---
K
M
K-
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
-
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
----
A
N
E
F
D
I
L
K
K
V
--
E
K
---
G
K
----
F
T
F
DL
P
----
Q
W
KK
V
S
E
P
A
K
D
L
I
R
K
M
L
A
Y
V
P
T
M
--
R
-----
I
-----
S
A
R
-
D
A
L
E
H
E
W
L
K
T
T
D
A
A
T
---
D
S
------------
244
Blastp_CBE
56.71
38%
-66
- C1 -
-
4WG5
4.4
-
?
A:
[32-285]
----------------------------------------------------------------------------------------------------------------------------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
---
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
-
R
Q
V
K
-
Q
-
K
T
-
D
K
E
S
L
L
R
E
V
Q
--
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
---
S
K
DAN-
I
R
I
I
D
F
G
L
---
S
--
T
-
H
--
F
-
E
-
A
--
S
---
K
---
K
M
K-
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
-
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
----
A
N
E
Y
D
I
L
K
K
V
--
E
K
---
G
K
----
Y
T
F
EL
P
----
Q
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
--
R
-----
I
-----
S
A
R
-
D
A
L
D
H
E
W
I
------------------------
250
Blastp_CBE
56.67
38%
-65
- C1 -
-
4JBV
6.4
-
?
A:
[32-290]
----------------------------------------------------------------------------------------------------------------------------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
---
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
-
R
Q
V
K
-
Q
-
K
T
-
D
K
E
S
L
L
R
E
V
Q
--
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
---
S
K
DAN-
I
R
I
I
D
F
G
L
---
S
--
T
-
H
--
F
-
E
-
A
--
S
---
K
---
K
M
K-
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
-
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
----
A
N
E
Y
D
I
L
K
K
V
--
E
K
---
G
K
----
Y
T
F
EL
P
----
Q
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
--
R
-----
I
-----
S
A
R
-
D
A
L
D
H
E
W
I
------------------------
235
Blastp_CBE
56.66
38%
-62
- C1 -
-
4MXA
4.9
-
?
A:
[33-292]
----------------------------------------------------------------------------------------------------------------------------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
---
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
-
R
Q
V
K
-
Q
-
K
T
-
D
K
E
S
L
L
R
E
V
Q
--
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
Y
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
---
S
K
DAN-
I
R
I
I
D
F
G
L
---
S
--
T
-
H
--
F
-
E
-
A
--
S
---
K
---
K
M
K-
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
-
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
----
A
N
E
Y
D
I
L
K
K
V
--
E
K
---
G
K
----
Y
T
F
EL
P
----
Q
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
--
R
-----
I
-----
S
A
R
-
D
A
L
D
H
E
W
I
------------------------
308
Blastp_CBE
56.63
37%
-88
- C1 -
-
1UU8
3.1
-
PDPK1_HUMAN
A:
[30-274]
----------------------------------------------------------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
-
R
E
---
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
-
R
H
I
I
-
K
-
E
N
-
K
V
P
Y
V
T
R
E
R
D
--
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
---
M
H
----
I
Q
I
T
D
F
G
T
---
A
K-
V
-
L
--
S
---------------
A
--
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
-
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
----
G
N
E
Y
L
I
F
Q
K
I
--
I
K
---
L
E
----
Y
D
F
--
P
----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
-----------------------------------------------
419
Blastp_CBE
56.64
33%
-74
- C1 -
-
4A4L
2.8
-
PLK1_HUMAN
A:
[25-274]
------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
G
G
F
A
K
C
F
E
I
-
S
D
---
A
---
D
T
K
E
V
F
A
G
K
I
V
P
K
-
S
L
L
L
-
K
-
P
H
-
Q
R
E
K
M
S
M
E
I
S
--
I
H
R
S
L
A
H
Q
H
V
V
G
F
H
G
F
F
E
D
N
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
L
E
L
H
K
R
R
-
K
A
-
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
-
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
E
D
---
L
E
----
V
K
I
G
D
F
G
L
---
A
TK
V
-
E
--
Y
-
D
-
G
--
E
---
R
---
K
K
--
T
-
L
----
C
G
T
P
N
Y
I
A
P
E
V
L
S
K
K
G
-
H
S
-
F
-
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
E
T
----
S
C
L
K
E
T
Y
L
R
I
--
K
K
---
N
E
----
Y
S
I
--
P
----
K
H
--
I
N
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
--
R
-----
P
-----
T
I
N
-
E
L
L
N
D
E
F
F
-
T
S
G
--------------------
245
Blastp_CBE
56.63
38%
-66
- C1 -
-
4WG4
6.1
-
?
A:
[32-296]
----------------------------------------------------------------------------------------------------------------------------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
---
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
-
R
Q
V
K
-
Q
-
K
T
-
D
K
E
S
L
L
R
E
V
Q
--
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
---
S
K
DAN-
I
R
I
I
D
F
G
L
---
S
--
T
-
H
--
F
-
E
-
A
--
S
---
K
---
K
M
K-
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
-
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
----
A
N
E
Y
D
I
L
K
K
V
--
E
K
---
G
K
----
Y
T
F
EL
P
----
Q
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
--
R
-----
I
-----
S
A
R
-
D
A
L
D
H
E
W
I
------------------------
400
Blastp_CBE
56.61
33%
-85
- C1 -
-
5KZ8
7.3
-
MARK2_HUMAN
B:
[30-288]
-------------------------------------------------------------------------------------------------------------------------------
P
H
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
-
R
H
---
I
---
L
T
G
K
E
V
A
V
K
I
I
D
K
-
T
Q
L
N
-
S
-
S
S
-
L
Q
-
K
L
F
R
E
V
R
--
I
M
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
-
G
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
D
---
M
N
----
I
K
I
A
D
F
----------------------------------------
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
-
Y
D
-
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
----
Q
N
L
K
E
L
R
E
R
V
--
L
R
---
G
K
----
Y
R
I
--
P
----
F
Y
--
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
--
R
-----
G
-----
T
L
E
-
Q
I
M
K
D
R
W
M
-
N
V
---------------------
249
Blastp_CBE
56.54
38%
-65
- C1 -
-
4M84
4.3
-
?
A:
[32-285]
----------------------------------------------------------------------------------------------------------------------------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
---
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
-
R
Q
V
K
-
Q
-
K
T
-
D
K
E
S
L
L
R
E
V
Q
--
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
---
S
K
DAN-
I
R
I
I
D
F
G
L
---
S
--
T
-
H
--
F
-
E
-
A
--
S
---
K
---
K
M
K-
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
-
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
----
A
N
E
Y
D
I
L
K
K
V
--
E
K
---
G
K
----
Y
T
F
EL
P
----
Q
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
--
R
-----
I
-----
S
A
R
-
D
A
L
D
H
E
W
I
------------------------
442
Blastp_CBE
56.52
33%
-72
- C1 -
-
3FC2
2.2
-
PLK1_HUMAN
A:
[49-298]
------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
G
G
F
A
K
C
F
E
I
-
S
D
---
A
---
D
T
K
E
V
F
A
G
K
I
V
P
K
-
S
L
L
L
-
K
-
P
H
-
Q
R
E
K
M
S
M
E
I
S
--
I
H
R
S
L
A
H
Q
H
V
V
G
F
H
G
F
F
E
D
N
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
L
E
L
H
K
R
R
-
K
A
-
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
-
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
E
D
---
L
E
----
V
K
I
G
D
F
G
L
---
A
TK
V
-
E
--
Y
-
D
-
G
--
E
---
R
---
K
K
--
V
-
L
----
C
G
T
P
N
Y
I
A
P
E
V
L
S
K
K
G
-
H
S
-
F
-
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
E
T
----
S
C
L
K
E
T
Y
L
R
I
--
K
K
---
N
E
----
Y
S
I
--
P
----
K
H
--
I
N
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
--
R
-----
P
-----
T
I
N
-
E
L
L
N
D
E
F
F
-
T
S
G
--------------------
338
Blastp_CBE
56.51
37%
-127
- C1 -
-
5LVP
5.1
-
PDPK1_HUMAN
B:
[32-276]
----------------------------------------------------------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
-
R
E
---
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
-
R
H
I
I
-
K
-
E
N
-
K
V
P
Y
V
T
R
E
R
D
--
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
---
M
H
----
I
Q
I
T
D
F
G
T
---
A
K-
V
-
L
--
S
------------------
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
-
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
----
G
N
E
G
L
I
F
A
K
I
--
I
K
---
L
E
----
Y
D
F
--
P
----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
-----------------------------------------------
266
Blastp_CBE
56.46
38%
-65
- C1 -
-
3KU2
4.8
-
?
A:
[55-315]
----------------------------------------------------------------------------------------------------------------------------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
---
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
-
R
Q
V
K
-
Q
-
K
T
-
D
K
E
S
L
L
R
E
V
Q
--
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
---
S
K
DAN-
I
R
I
I
D
F
G
L
---
S
--
T
-
H
--
F
-
E
-
A
--
S
---
K
---
K
M
K-
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
-
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
----
A
N
E
Y
D
I
L
K
K
V
--
E
K
---
G
K
----
Y
T
F
EL
P
----
Q
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
--
R
-----
I
-----
S
A
R
-
D
A
L
D
H
E
W
I
------------------------
339
Blastp_CBE
56.44
37%
-136
- C1 -
-
5LVP
5.2
-
PDPK1_HUMAN
A:
[32-276]
----------------------------------------------------------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
-
R
E
---
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
-
R
H
I
I
-
K
-
E
N
-
K
V
P
Y
V
T
R
E
R
D
--
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
---
M
H
----
I
Q
I
T
D
F
G
T
---
A
K-
V
-
L
--
S
--------------------
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
-
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
----
G
N
E
G
L
I
F
A
K
I
--
I
K
---
L
E
----
Y
D
F
--
P
----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
-----------------------------------------------
417
Blastp_CBE
56.42
33%
-73
- C1 -
-
3KB7
2.5
-
PLK1_HUMAN
A:
[25-272]
------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
G
G
F
A
K
C
F
E
I
-
S
D
---
A
---
D
T
K
E
V
F
A
G
K
I
V
P
K
-
S
L
L
L
-
K
-
P
H
-
Q
R
E
K
M
S
M
E
I
S
--
I
H
R
S
L
A
H
Q
H
V
V
G
F
H
G
F
F
E
D
N
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
L
E
L
H
K
R
R
-
K
A
-
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
-
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
E
D
---
L
E
----
V
K
I
G
D
F
G
L
---
A
TK
V
-
E
--
Y
-
D
-
G
--
E
---
R
---
K
K
--
T
-
L
----
C
G
T
P
N
Y
I
A
P
E
V
L
S
K
K
G
-
H
S
-
F
-
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
E
T
----
S
C
L
K
E
T
Y
L
R
I
--
K
K
---
N
E
----
Y
S
I
--
P
----
K
H
--
I
N
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
--
R
-----
P
-----
T
I
N
-
E
L
L
N
D
E
F
F
-
T
S
G
--------------------
420
Blastp_CBE
56.39
33%
-73
- C1 -
-
2YAC
2.8
-
PLK1_HUMAN
A:
[25-274]
------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
G
G
F
A
K
C
F
E
I
-
S
D
---
A
---
D
T
K
E
V
F
A
G
K
I
V
P
K
-
S
L
L
L
-
K
-
P
H
-
Q
R
E
K
M
S
M
E
I
S
--
I
H
R
S
L
A
H
Q
H
V
V
G
F
H
G
F
F
E
D
N
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
L
E
L
H
K
R
R
-
K
A
-
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
-
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
E
D
---
L
E
----
V
K
I
G
D
F
G
L
---
A
TK
V
-
E
--
Y
-
D
-
G
--
E
---
R
---
K
K
--
T
-
L
----
C
G
T
P
N
Y
I
A
P
E
V
L
S
K
K
G
-
H
S
-
F
-
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
E
T
----
S
C
L
K
E
T
Y
L
R
I
--
K
K
---
N
E
----
Y
S
I
--
P
----
K
H
--
I
N
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
--
R
-----
P
-----
T
I
N
-
E
L
L
N
D
E
F
F
-
T
S
G
--------------------
247
Blastp_CBE
56.32
38%
-65
- C1 -
-
4TZR
5.0
-
?
A:
[32-290]
----------------------------------------------------------------------------------------------------------------------------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
---
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
-
R
Q
V
K
-
Q
-
K
T
-
D
K
E
S
L
L
R
E
V
Q
--
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
---
S
K
DAN-
I
R
I
I
D
F
G
L
---
S
--
T
-
H
--
F
-
E
-
A
--
S
---
K
---
K
M
K-
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
-
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
----
A
N
E
Y
D
I
L
K
K
V
--
E
K
---
G
K
----
Y
T
F
EL
P
----
Q
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
--
R
-----
I
-----
S
A
R
-
D
A
L
D
H
E
W
I
------------------------
264
Blastp_CBE
56.33
38%
-66
- C1 -
-
4IH8
6.5
-
?
A:
[55-336]
----------------------------------------------------------------------------------------------------------------------------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
---
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
-
R
Q
V
K
-
Q
-
K
T
-
D
K
E
S
L
L
R
E
V
Q
--
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
-----
S
K
DAN-
I
R
I
I
D
F
G
L
---
S
--
T
-
H
--
F
-
E
-
A
--
S
---
K
---
K
M
K-
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
-
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
----
A
N
E
Y
D
I
L
K
K
V
--
E
K
---
G
K
----
Y
T
F
EL
P
----
Q
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
--
R
-----
I
-----
S
A
R
-
D
A
L
D
H
E
W
I
------------------------
237
Blastp_CBE
56.32
38%
-65
- C1 -
-
6BFA
4.7
-
?
A:
[32-285]
----------------------------------------------------------------------------------------------------------------------------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
---
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
-
R
Q
V
K
-
Q
-
K
T
-
D
K
E
S
L
L
R
E
V
Q
--
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
---
S
K
DAN-
I
R
I
I
D
F
G
L
---
S
--
T
-
H
--
F
-
E
-
A
--
S
---
K
---
K
M
K-
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
-
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
----
A
N
E
Y
D
I
L
K
K
V
--
E
K
---
G
K
----
Y
T
F
EL
P
----
Q
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
--
R
-----
I
-----
S
A
R
-
D
A
L
D
H
E
W
I
------------------------
238
Blastp_CBE
56.19
38%
-66
- C1 -
-
5W9R
6.4
-
?
A:
[32-304]
----------------------------------------------------------------------------------------------------------------------------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
---
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
-
R
Q
V
K
-
Q
-
K
T
-
D
K
E
S
L
L
R
E
V
Q
--
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
---
S
K
DAN-
I
R
I
I
D
F
G
L
---
S
--
T
-
H
--
F
-
E
-
A
--
S
---
K
---
K
M
K-
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
-
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
----
A
N
E
Y
D
I
L
K
K
V
--
E
K
---
G
K
----
Y
T
F
EL
P
----
Q
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
--
R
-----
I
-----
S
A
R
-
D
A
L
D
H
E
W
I
------------------------
246
Blastp_CBE
56.17
38%
-68
- C1 -
-
4WG3
7.1
-
?
A:
[32-290]
----------------------------------------------------------------------------------------------------------------------------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
---
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
-
R
Q
V
K
-
Q
-
K
T
-
D
K
E
S
L
L
R
E
V
Q
--
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
---
S
K
DAN-
I
R
I
I
D
F
G
L
---
S
--
T
-
H
--
F
-
E
-
A
--
S
---
K
---
K
M
K-
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
-
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
----
A
N
E
Y
D
I
L
K
K
V
--
E
K
---
G
K
----
Y
T
F
EL
P
----
Q
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
--
R
-----
I
-----
S
A
R
-
D
A
L
D
H
E
W
I
------------------------
482
Blastp_CBE
56.08
35%
-50
- C1 -
-
4Y5Q
4.8
-
?
A:
[22-307]
----------------------------------------------------------------------------------------------------------------------------------
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
-
K
D
---
R
---
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
-
A
S
A
K
-
N
-
K
D
-
T
S
T
I
L
R
-
E
V
E
--
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
-
K
R
-
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
EKD
C
D
----
I
K
I
I
D
F
G
L
---
S
--
T
C
F
--
Q
-
Q
-
N
--
T
-----------
D
-
R
----
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
-
T
-
Y
D
-
E
-
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
----
K
N
E
Y
D
I
L
K
R
V
ET
G
K
---
Y
A
----
F
D
L
--
P
----
Q
W
RT
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
--
R
-----
I
-----
T
A
T
-
Q
C
L
E
H
P
W
I
-
Q
K
Y
S
S
E
---
T
-------------
252
Blastp_CBE
56.04
38%
-67
- C1 -
-
3V5P
5.2
-
?
A:
[32-300]
----------------------------------------------------------------------------------------------------------------------------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
---
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
-
R
Q
V
K
-
Q
-
K
T
-
D
K
E
S
L
L
R
E
V
Q
--
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
---
S
K
DAN-
I
R
I
I
D
F
G
L
---
S
--
T
-
H
--
F
-
E
-
A
--
S
---
K
---
K
M
K-
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
-
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
----
A
N
E
Y
D
I
L
K
K
V
--
E
K
---
G
K
----
Y
T
F
EL
P
----
Q
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
--
R
-----
I
-----
S
A
R
-
D
A
L
D
H
E
W
I
------------------------
222
Blastp_CBE
55.98
38%
-107
- C1 -
-
4YUR
6.2
-
PLK4_HUMAN
A:
[12-269]
---------------------------------------------------------------------------------------------------------------------------------
I
E
D
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
-
E
S
---
I
---
H
T
G
L
E
V
A
I
K
M
I
D
K
-
K
A
M
Y
-
K
-
A
G
-
M
V
Q
R
V
Q
N
E
V
K
--
I
H
C
Q
L
K
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
R
-
V
K
P
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
-
H
G
I
L
H
R
D
L
T
L
S
N
L
L
L
T
R
N
---
M
N
----
I
K
I
A
D
F
---------------------------------------------------------
G
-
L
-
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
-------
T
V
K
N
T
L
N
K
V
--
V
L
---
A
D
----
Y
E
M
--
P
----
S
F
--
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
--
R
-----
L
-----
S
L
S
-
S
V
L
D
H
P
F
M
-
S
----------------------
242
Blastp_CBE
55.96
38%
-68
- C1 -
-
5W80
5.9
-
?
A:
[32-296]
----------------------------------------------------------------------------------------------------------------------------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
---
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
-
R
Q
V
K
-
Q
-
K
T
-
D
K
E
S
L
L
R
E
V
Q
--
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
---
S
K
DAN-
I
R
I
I
D
F
G
L
---
S
--
T
-
H
--
F
-
E
-
A
--
S
---
K
---
K
M
K-
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
-
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
----
A
N
E
Y
D
I
L
K
K
V
--
E
K
---
G
K
----
Y
T
F
EL
P
----
Q
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
--
R
-----
I
-----
S
A
R
-
D
A
L
D
H
E
W
I
------------------------
258
Blastp_CBE
55.91
38%
-63
- C1 -
-
3SXF
4.3
-
?
A:
[32-296]
----------------------------------------------------------------------------------------------------------------------------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
---
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
-
R
Q
V
K
-
Q
-
K
T
-
D
K
E
S
L
L
R
E
V
Q
--
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
---
S
K
DAN-
I
R
I
I
D
F
G
L
---
S
--
T
-
H
--
F
-
E
-
A
--
S
---
K
---
K
M
K-
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
-
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
----
A
N
E
Y
D
I
L
K
K
V
--
E
K
---
G
K
----
Y
T
F
EL
P
----
Q
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
--
R
-----
I
-----
S
A
R
-
D
A
L
D
H
E
W
I
------------------------
531
Blastp_CBE
55.87
33%
-47
- C1 -
-
4RA5
3.1
-
KPCT_HUMAN
A:
[4-259]
---------------------------------------------------------------------------------------------------------------------------------
I
E
D
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
-
E
F
---
K
---
K
T
N
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
M
-
D
-
D
D
-
V
E
C
T
M
V
E
K
R
V
--
L
S
L
A
W
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
-
H
K
-
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
---
G
H
----
I
K
I
A
D
F
G
M
---
C
--
K
-
E
NM
L
-
G
-
D
--
A
---
K
---
T
N
--
E
-
F
----
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
K
-
Y
N
-
H
-
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
H
G
----
Q
D
E
E
E
L
F
H
S
I
--
R
M
---
D
N
----
P
F
Y
--
P
----
R
W
--
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
-----
L
-----
G
V
R
G
D
I
R
Q
H
P
--------------------------
275
Blastp_CBE
55.84
38%
-63
- C1 -
-
5JN2
5.6
-
?
A:
[73-341]
----------------------------------------------------------------------------------------------------------------------------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
---
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
-
R
Q
V
K
-
Q
-
K
T
-
D
K
E
S
L
L
R
E
V
Q
--
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
---
S
K
DAN-
I
R
I
I
D
F
G
L
---
S
--
T
-
H
--
F
-
E
-
A
--
S
---
K
---
K
M
K-
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
-
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
----
A
N
E
Y
D
I
L
K
K
V
--
E
K
---
G
K
----
Y
T
F
EL
P
----
Q
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
--
R
-----
I
-----
S
A
R
-
D
A
L
D
H
E
W
I
------------------------
233
Blastp_CBE
55.83
38%
-63
- C1 -
-
3MA6
4.7
-
?
A:
[38-291]
----------------------------------------------------------------------------------------------------------------------------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
---
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
-
R
Q
V
K
-
Q
-
K
T
-
D
K
E
S
L
L
R
E
V
Q
--
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
---
S
K
DAN-
I
R
I
I
D
F
G
L
---
S
--
T
-
H
--
F
-
E
----
S
---
K
---
K
M
K-
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
-
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
----
A
N
E
Y
D
I
L
K
K
V
--
E
K
---
G
K
----
Y
T
F
EL
P
----
Q
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
--
R
-----
I
-----
S
A
R
-
D
A
L
D
H
E
W
I
------------------------
239
Blastp_CBE
55.78
38%
-66
- C1 -
-
5W9E
5.2
-
?
A:
[32-298]
----------------------------------------------------------------------------------------------------------------------------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
---
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
-
R
Q
V
K
-
Q
-
K
T
-
D
K
E
S
L
L
R
E
V
Q
--
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
---
S
K
DAN-
I
R
I
I
D
F
G
L
---
S
--
T
-
H
--
F
-
E
-
A
--
S
---
K
---
K
M
K-
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
-
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
----
A
N
E
Y
D
I
L
K
K
V
--
E
K
---
G
K
----
Y
T
F
EL
P
----
Q
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
--
R
-----
I
-----
S
A
R
-
D
A
L
D
H
E
W
I
------------------------
260
Blastp_CBE
55.74
38%
-62
- C1 -
-
3N51
5.9
-
?
A:
[32-300]
----------------------------------------------------------------------------------------------------------------------------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
---
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
-
R
Q
V
K
-
Q
-
K
T
-
D
K
E
S
L
L
R
E
V
Q
--
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
---
S
K
DAN-
I
R
I
I
D
F
G
L
---
S
--
T
-
H
--
F
-
E
-
A
--
S
---
K
---
K
M
K-
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
-
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
----
A
N
E
Y
D
I
L
K
K
V
--
E
K
---
G
K
----
Y
T
F
EL
P
----
Q
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
--
R
-----
I
-----
S
A
R
-
D
A
L
D
H
E
W
I
------------------------
257
Blastp_CBE
55.63
38%
-64
- C1 -
-
3T3U
4.8
-
?
A:
[32-296]
----------------------------------------------------------------------------------------------------------------------------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
---
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
-
R
Q
V
K
-
Q
-
K
T
-
D
K
E
S
L
L
R
E
V
Q
--
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
---
S
K
DAN-
I
R
I
I
D
F
G
L
---
S
--
T
-
H
--
F
-
E
-
A
--
S
---
K
---
K
M
K-
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
-
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
----
A
N
E
Y
D
I
L
K
K
V
--
E
K
---
G
K
----
Y
T
F
EL
P
----
Q
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
--
R
-----
I
-----
S
A
R
-
D
A
L
D
H
E
W
I
------------------------
261
Blastp_CBE
55.52
38%
-62
- C1 -
-
3I7B
6.4
-
?
A:
[32-288]
----------------------------------------------------------------------------------------------------------------------------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
---
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
-
R
Q
V
K
-
Q
-
K
T
-
D
K
E
S
L
L
R
E
V
Q
--
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
---
S
K
DAN-
I
R
I
I
D
F
G
L
---
S
--
T
-
H
--
F
-
E
-
A
--
S
---
K
---
K
M
K-
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
-
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
----
A
N
E
Y
D
I
L
K
K
V
--
E
K
---
G
K
----
Y
T
F
EL
P
----
Q
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
--
R
-----
I
-----
S
A
R
-
D
A
L
D
H
E
W
I
------------------------
265
Blastp_CBE
55.35
38%
-67
- C1 -
-
4IFG
6.3
-
?
A:
[55-320]
----------------------------------------------------------------------------------------------------------------------------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
---
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
-
R
Q
V
K
-
Q
-
K
T
-
D
K
E
S
L
L
R
E
V
Q
--
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
---
S
K
DAN-
I
R
I
I
D
F
G
L
---
S
--
T
-
H
--
F
-
E
-
A
--
S
---
K
---
K
M
K-
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
-
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
----
A
N
E
Y
D
I
L
K
K
V
--
E
K
---
G
K
----
Y
T
F
EL
P
----
Q
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
--
R
-----
I
-----
S
A
R
-
D
A
L
D
H
E
W
I
------------------------
407
Blastp_CBE
54.85
36%
-58
- C1 -
-
3HZT
5.3
-
?
A:
[10-301]
----------------------------------------------------------------------------------------------------------------------------------------
K
K
L
G
S
G
A
Y
G
E
V
L
L
C
-
K
D
---
K
---
L
T
G
A
E
R
A
I
K
I
I
K
K
-
S
S
V
T
-
T
-
T
S
-
N
S
G
A
L
L
D
E
V
A
--
V
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
R
N
Y
Y
L
V
M
E
V
Y
R
G
G
E
L
F
D
E
I
I
L
R
-
Q
K
-
F
S
E
V
D
A
A
V
I
M
K
Q
V
L
S
G
T
T
Y
L
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
---
S
R
DAL-
I
K
I
V
D
F
G
L
---
S
--
A
-
H
--
F
-
E
V-----------------------
G
T
A
Y
Y
I
A
P
E
V
L
R
-
K
K
-
Y
D
-
E
-
K
C
D
V
W
S
C
G
V
I
L
Y
I
L
L
C
G
Y
P
P
F
G
G
----
Q
T
D
Q
E
I
L
K
R
V
--
E
K
---
G
K
----
F
S
F
DP
P
----
D
W
TQ
V
S
D
E
A
K
Q
L
V
K
L
M
L
T
Y
E
P
S
K
--
R
-----
I
-----
S
A
E
-
E
A
L
N
H
P
W
I
-
V
K
F
C
S
Q
-----------------
558
HHSearch
54.62
38%
-80
- C1 -
-
4JXF
3.4
-
PLK4_HUMAN
A:
[6-264]
---------------------------------------------------------------------------------------------------------------------------------
I
E
D
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
-
E
S
---
I
---
H
T
G
L
E
V
A
I
K
M
I
D
K
-
K
A
M
Y
-
K
-
A
G
-
M
V
Q
R
V
Q
N
E
V
K
--
I
H
C
Q
L
K
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
R
V
K
P
-
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
-
H
G
I
L
H
R
D
L
T
L
S
N
L
L
L
T
R
N
---
M
N
----
I
K
I
A
D
F
G
L
---
A
--
T
-
Q
--
L
-
K
-
M
--
P
H---------------------------------------
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
--------
V
K
N
T
L
N
K
V
--
V
L
---
A
D
----
Y
E
M
--
P
----
S
F
--
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
--
R
-----
L
-----
S
L
S
-
S
V
L
D
H
P
F
M
-
S
R
---------------------
418
Blastp_CBE
54.63
33%
-67
- C1 -
-
4A4O
2.7
-
PLK1_HUMAN
A:
[25-274]
------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
G
G
F
A
K
C
F
E
I
-
S
D
---
A
---
D
T
K
E
V
F
A
G
K
I
V
P
K
-
S
L
L
L
-
K
-
P
H
-
Q
R
E
K
M
S
M
E
I
S
--
I
H
R
S
L
A
H
Q
H
V
V
G
F
H
G
F
F
E
D
N
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
L
E
L
H
K
R
R
-
K
A
-
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
-
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
E
D
---
L
E
----
V
K
I
G
D
F
G
L
---
A
TK
V
-
E
--
Y
-
D
-
G
--
E
---
R
---
K
K
--
T
-
L
----
C
G
T
P
N
Y
I
A
P
E
V
L
S
K
K
G
-
H
S
-
F
-
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
E
T
----
S
C
L
K
E
T
Y
L
R
I
--
K
K
---
N
E
----
Y
S
I
--
P
----
K
H
--
I
N
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
--
R
-----
P
-----
T
I
N
-
E
L
L
N
D
E
F
F
-
T
S
G
--------------------
485
Blastp_CBE
54.62
35%
-54
- C1 -
-
3IGO
5.4
-
?
A:
[22-302]
----------------------------------------------------------------------------------------------------------------------------------
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
-
K
D
---
R
---
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
-
A
S
A
K
-
N
-
K
--
T
S
T
I
L
R
-
E
V
E
--
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
-
K
R
-
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
EKD
C
D
----
I
K
I
I
D
F
G
L
---
S
--
T
C
F
--
Q
-
Q
-
N
--
T
--------------------
T
A
Y
Y
I
A
P
E
V
L
R
G
-
T
-
Y
D
-
E
-
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
----
K
N
E
Y
D
I
L
K
R
V
ET
G
K
---
Y
A
----
F
D
L
--
P
----
Q
W
RT
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
--
R
-----
I
-----
T
A
T
-
Q
C
L
E
H
P
W
I
-
Q
K
Y
S
S
E
---
T
-------------
223
Blastp_CBE
54.56
38%
-77
- C1 -
-
4JXF
3.4
-
PLK4_HUMAN
A:
[6-264]
---------------------------------------------------------------------------------------------------------------------------------
I
E
D
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
-
E
S
---
I
---
H
T
G
L
E
V
A
I
K
M
I
D
K
-
K
A
M
Y
-
K
-
A
G
-
M
V
Q
R
V
Q
N
E
V
K
--
I
H
C
Q
L
K
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
R
-
V
K
P
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
-
H
G
I
L
H
R
D
L
T
L
S
N
L
L
L
T
R
N
---
M
N
----
I
K
I
A
D
F
G
L
---
A
TQ
L
-
K
--
M
-
P
-
H
-------------------------------------------
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
--------
V
K
N
T
L
N
K
V
--
V
L
---
A
D
----
Y
E
M
--
P
----
S
F
--
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
--
R
-----
L
-----
S
L
S
-
S
V
L
D
H
P
F
M
-
S
R
---------------------
220
Blastp_CBE
54.41
38%
-92
- C1 -
-
3COK
5.6
-
PLK4_HUMAN
B:
[10-267]
---------------------------------------------------------------------------------------------------------------------------------
I
E
D
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
-
E
S
---
I
---
H
T
G
L
E
V
A
I
K
M
I
D
K
-
K
A
M
Y
-
K
-
A
G
-
M
V
Q
R
V
Q
N
E
V
K
--
I
H
C
Q
L
K
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
R
-
V
K
P
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
-
H
G
I
L
H
R
D
L
T
L
S
N
L
L
L
T
R
N
---
M
N
----
I
K
I
A
D
F
G
L
---
A
TQ
L
-
K
------------------------------------------------
L
-
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
----------
N
T
L
N
K
V
--
V
L
---
A
D
----
Y
E
M
--
P
----
S
F
--
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
--
R
-----
L
-----
S
L
S
-
S
V
L
D
H
P
F
M
-
S
----------------------
232
Blastp_CBE
54.21
38%
-56
- C1 -
-
3MA6
5.9
-
?
B:
[38-291]
----------------------------------------------------------------------------------------------------------------------------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
---
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
-
R
Q
V
K
-
Q
--
T
-
D
K
E
S
L
L
R
E
V
Q
--
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
---
S
K
DAN-
I
R
I
I
D
F
G
L
---
S
--
T
-
H
--
F
-
E
-
A
--
S
---
K
---
K
M
K-
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
-
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
----
A
N
E
Y
D
I
L
K
K
V
--
E
K
---
G
K
----
Y
T
F
EL
P
----
Q
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
--
R
-----
I
-----
S
A
R
-
D
A
L
D
H
E
W
I
------------------------
535
Blastp_CBE
53.40
36%
-36
- C1 -
-
3E8D
6.6
-
AKT2_HUMAN
A:
[3-285]
--------------------------------------------------------------------------------------------------------------------------------
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
-
R
E
---
K
---
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
-
D
E
-
V
A
H
T
V
T
-
E
S
R
--
V
L
Q
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
---
G
H
----
I
K
I
T
D
F
G
L
---
C
--
K
-
E
--
G
-
I
-
S
--
D
---
G
---
A
T
--
M
K
F
----
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-
Y
G
-
R
-
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
----
Q
D
H
E
R
L
F
E
L
I
--
L
M
---
E
E
----
I
R
F
--
P
----
R
T
--
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
LGGGP
S
-----
D
A
K
-
E
V
M
E
H
R
F
F
-
L
S
---------------------
349
Blastp_CBE
53.04
37%
-86
- C1 -
-
4A06
4.4
-
PDPK1_HUMAN
A:
[32-276]
----------------------------------------------------------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
-
R
E
---
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
-
R
H
I
I
-
K
-
E
N
-
K
V
P
Y
V
T
R
E
R
D
--
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
---
M
H
----
I
Q
I
T
D
F
G
T
---
A
K-
V
-
L
--
S
-
P
-
E
--
S
---
K
QA-
R
A
--
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
-
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
----
G
N
E
G
L
I
F
A
K
I
--
I
K
---
L
E
----
Y
D
F
--
P
----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
-----------------------------------------------
528
Blastp_CBE
52.82
36%
-35
- C1 -
-
1O6K
7.0
-
AKT2_HUMAN
A:
[3-282]
--------------------------------------------------------------------------------------------------------------------------------
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
-
R
E
---
K
---
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
-
D
E
-
V
A
H
T
V
T
-
E
S
R
--
V
L
Q
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
---
G
H
----
I
K
I
T
D
F
G
L
---
C
--
K
-
E
--
G
-
I
-
S
--
D
---
G
---
A
T
--
M
K
F
----
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-
Y
G
-
R
-
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
----
Q
D
H
E
R
L
F
E
L
I
--
L
M
---
E
E
----
I
R
F
--
P
----
R
T
--
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
LGGGP
S
-----
D
A
K
-
E
V
M
E
H
R
F
F
-
L
S
---------------------
534
Blastp_CBE
52.42
36%
-37
- C1 -
-
3E8D
6.8
-
AKT2_HUMAN
B:
[3-283]
--------------------------------------------------------------------------------------------------------------------------------
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
-
R
E
---
K
---
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
-
D
E
-
V
A
H
T
V
T
-
E
S
R
--
V
L
Q
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
---
G
H
----
I
K
I
T
D
F
G
L
---
C
--
K
-
E
--
G
-
I
-
S
--
D
---
G
---
A
T
--
M
K
F
----
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-
Y
G
-
R
-
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
----
Q
D
H
E
R
L
F
E
L
I
--
L
M
---
E
E
----
I
R
F
--
P
----
R
T
--
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
LGGGP
S
-----
D
A
K
-
E
V
M
E
H
R
F
F
-
L
S
---------------------
359
Blastp_CBE
52.26
37%
-78
- C1 -
-
3QC4
10.8
-
PDPK1_HUMAN
B:
[35-279]
----------------------------------------------------------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
-
R
E
---
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
-
R
H
I
-----------
V
T
R
E
R
D
--
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
---
M
H
----
I
Q
I
T
D
F
G
T
---
A
K-
V
-
L
--
S
-
P
-
E
--
S
-------------
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
-
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
----
G
N
E
Y
L
I
F
Q
K
I
--
I
K
---
L
E
----
Y
D
F
--
P
----
A
A
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
-----------------------------------------------
536
Blastp_CBE
52.13
36%
-33
- C1 -
-
3E88
7.5
-
AKT2_HUMAN
B:
[3-280]
--------------------------------------------------------------------------------------------------------------------------------
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
-
R
E
---
K
---
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
-
D
E
-
V
A
H
T
V
T
-
E
S
R
--
V
L
Q
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
---
G
H
----
I
K
I
T
D
F
G
L
---
C
--
K
-
E
--
G
-
I
-
S
--
D
---
G
---
A
T
--
M
K
F
----
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-
Y
G
-
R
-
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
----
Q
D
H
E
R
L
F
E
L
I
--
L
M
---
E
E
----
I
R
F
--
P
----
R
T
--
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
LGGGP
S
-----
D
A
K
-
E
V
M
E
H
R
F
F
-
L
S
---------------------
350
Blastp_CBE
52.11
37%
-83
- C1 -
-
3RCJ
5.7
-
PDPK1_HUMAN
A:
[32-276]
----------------------------------------------------------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
-
R
E
---
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
-
R
H
I
I
-
K
-
E
N
-
K
V
P
Y
V
T
R
E
R
D
--
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
---
M
H
----
I
Q
I
T
D
F
G
T
---
A
K-
V
-
L
--
S
-
P
-
E
--
S
---
K
QA-
R
A
--
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
-
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
----
G
N
E
G
L
I
F
A
K
I
--
I
K
---
L
E
----
Y
D
F
--
P
----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
-----------------------------------------------
405
Blastp_CBE
52.08
35%
-29
- C1 -
-
3AMA
6.5
-
KAPCA_HUMAN
A:
[41-307]
---------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
R
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
---
K
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
-
Q
K
V
V
-
K
-
L
K
Q
I
E
H
T
L
N
-
E
K
R
--
I
Q
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
---
G
Y
----
I
K
V
A
D
F
G
F
---
A
--
K
-
R
--
V
-
K
-
G
----------
R
T
--
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-
Y
N
-
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
----
D
Q
P
I
Q
I
Y
E
K
I
--
V
S
---
G
K
----
V
R
F
--
P
----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
FGNLK
N
-----
G
V
N
-
D
I
K
N
H
K
W
F
-
A
T
T
D
-------------------
221
Blastp_CBE
52.01
38%
-83
- C1 -
-
3COK
6.6
-
PLK4_HUMAN
A:
[10-267]
---------------------------------------------------------------------------------------------------------------------------------
I
E
D
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
-
E
S
---
I
---
H
T
G
L
E
V
A
I
K
M
I
D
K
-
K
A
M
Y
-
K
-
A
G
-
M
V
Q
R
V
Q
N
E
V
K
--
I
H
C
Q
L
K
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
R
-
V
K
P
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
-
H
G
I
L
H
R
D
L
T
L
S
N
L
L
L
T
R
N
---
M
N
----
I
K
I
A
D
F
G
L
---
A
TQ
L
-
K
--------------------------------------------------
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
D
T
----
D
T
V
-----
K
V
--
V
L
---
A
D
----
Y
E
M
--
P
----
S
F
--
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
--
R
-----
L
-----
S
L
S
-
S
V
L
D
H
P
F
M
-
S
----------------------
537
Blastp_CBE
51.91
36%
-33
- C1 -
-
3E88
7.5
-
AKT2_HUMAN
A:
[3-280]
--------------------------------------------------------------------------------------------------------------------------------
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
-
R
E
---
K
---
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
-
D
E
-
V
A
H
T
V
T
-
E
S
R
--
V
L
Q
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
---
G
H
----
I
K
I
T
D
F
G
L
---
C
--
K
-
E
--
G
-
I
-
S
--
D
---
G
---
A
T
--
M
K
F
----
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-
Y
G
-
R
-
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
----
Q
D
H
E
R
L
F
E
L
I
--
L
M
---
E
E
----
I
R
F
--
P
----
R
T
--
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
LGGGP
S
-----
D
A
K
-
E
V
M
E
H
R
F
F
-
L
S
---------------------
433
Blastp_CBE
51.80
35%
-29
- C1 -
-
6FRX
7.3
-
KAPCA_HUMAN
A:
[41-307]
---------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
R
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
---
K
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
-
Q
K
V
V
-
K
-
L
K
Q
I
E
H
T
L
N
-
E
K
R
--
I
Q
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
---
G
Y
----
I
K
V
A
D
F
G
F
---
A
--
K
-
R
--
V
-
K
-
G
----------
R
T
--
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-
Y
N
-
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
----
D
Q
P
I
Q
I
Y
E
K
I
--
V
S
---
G
K
----
V
R
F
--
P
----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
FGNLK
N
-----
G
V
N
-
D
I
K
N
H
K
W
F
-
A
T
T
D
-------------------
540
Blastp_CBE
51.69
36%
-36
- C1 -
-
3D0E
7.0
-
AKT2_HUMAN
B:
[3-277]
--------------------------------------------------------------------------------------------------------------------------------
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
-
R
E
---
K
---
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
-
D
E
-
V
A
H
T
V
T
-
E
S
R
--
V
L
Q
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
---
G
H
----
I
K
I
T
D
F
G
L
---
C
--
K
-
E
--
G
-
I
-
S
--
D
---
G
---
A
T
--
M
K
F
----
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-
Y
G
-
R
-
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
----
Q
D
H
E
R
L
F
E
L
I
--
L
M
---
E
E
----
I
R
F
--
P
----
R
T
--
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
LGGGP
S
-----
D
A
K
-
E
V
M
E
H
R
F
F
-
L
S
---------------------
285
Blastp_CBE
51.42
37%
-74
- C1 -
-
1H1W
4.6
-
PDPK1_HUMAN
A:
[10-254]
----------------------------------------------------------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
-
R
E
---
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
-
R
H
I
I
-
K
-
E
N
-
K
V
P
Y
V
T
R
E
R
D
--
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
---
M
H
----
I
Q
I
T
D
F
G
T
---
A
K-
V
-
L
--
S
-
P
---------A--
R
A
--
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
-
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
----
G
N
E
Y
L
I
F
Q
K
I
--
I
K
---
L
E
----
Y
D
F
--
P
----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
-----------------------------------------------
404
Blastp_CBE
51.36
35%
-33
* C1 *
-
3AMB
7.1
-
KAPCA_HUMAN
A:
[41-307]
---------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
R
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
---
K
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
-
Q
K
V
V
-
K
-
L
K
Q
I
E
H
T
L
N
-
E
K
R
--
I
Q
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
---
G
Y
----
I
K
V
A
D
F
G
F
---
A
--
K
-
R
--
V
-
K
-
G
----------
R
T
--
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-
Y
N
-
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
----
D
Q
P
I
Q
I
Y
E
K
I
--
V
S
---
G
K
----
V
R
F
--
P
----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
FGNLK
N
-----
G
V
N
-
D
I
K
N
H
K
W
F
-
A
T
T
D
-------------------
541
Blastp_CBE
51.29
36%
-36
- C1 -
-
3D0E
7.0
-
AKT2_HUMAN
A:
[3-277]
--------------------------------------------------------------------------------------------------------------------------------
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
-
R
E
---
K
---
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
-
D
E
-
V
A
H
T
V
T
-
E
S
R
--
V
L
Q
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
---
G
H
----
I
K
I
T
D
F
G
L
---
C
--
K
-
E
--
G
-
I
-
S
--
D
---
G
---
A
T
--
M
K
F
----
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-
Y
G
-
R
-
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
----
Q
D
H
E
R
L
F
E
L
I
--
L
M
---
E
E
----
I
R
F
--
P
----
R
T
--
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
LGGGP
S
-----
D
A
K
-
E
V
M
E
H
R
F
F
-
L
S
---------------------
284
Blastp_CBE
51.21
37%
-75
- C1 -
-
1UVR
3.0
-
PDPK1_HUMAN
A:
[10-254]
----------------------------------------------------------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
-
R
E
---
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
-
R
H
I
I
-
K
-
E
N
-
K
V
P
Y
V
T
R
E
R
D
--
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
---
M
H
----
I
Q
I
T
D
F
G
T
---
A
K-
V
-
L
--
S
-
P
---------A--
R
A
--
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
-
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
----
G
N
E
Y
L
I
F
Q
K
I
--
I
K
---
L
E
----
Y
D
F
--
P
----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
-----------------------------------------------
521
Blastp_CBE
51.09
32%
-35
- C1 -
-
2GNH
5.7
-
KAPCA_BOVIN
A:
[40-301]
---------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
-
K
H
---
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
-
Q
K
V
V
-
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
--
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
I
-
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
---
G
Y
----
I
K
V
A
D
F
G
F
---
A
--
K
-
R
--
V
-
K
-
G
----------
R
T
--
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-
Y
N
-
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
----
D
Q
P
I
Q
I
Y
E
K
I
--
V
S
---
G
K
----
V
R
F
--
P
----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
FGNLK
N
-----
G
V
N
-
D
I
K
N
H
K
W
F
-
A
T
T
D
-------------------
437
Blastp_CBE
51.02
32%
-43
- C1 -
-
4FG8
4.0
-
KCC1A_HUMAN
B:
[26-293]
------------------------------------------------------------------------------------------------------------------------------------------
L
G
T
G
A
F
S
E
V
I
L
A
-
E
D
---
K
---
R
T
Q
K
L
V
A
I
K
C
I
A
K
-----------------
N
E
I
A
--
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
-
G
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
-
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
---
D
E
DSK-
I
M
I
S
D
F
G
----------------
G
--
S
---
V
---
L
S
--
T
-
A
----
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
-
Y
S
-
K
-
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
----
E
N
D
A
K
L
F
E
Q
I
--
L
K
---
A
E
----
Y
E
F
--
D
SPYW
D
D
--
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
--
R
-----
F
-----
T
C
E
-
Q
A
L
Q
H
P
W
I
-
A
G
D
T
A
L
---
D
K
N
I
H
--
Q
S
V
S
E
Q
-
314
Blastp_CBE
50.91
37%
-72
- C1 -
-
3RWQ
6.8
-
PDPK1_HUMAN
A:
[32-276]
----------------------------------------------------------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
-
R
E
---
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
-
R
H
I
I
-
K
-
E
N
-
K
V
P
Y
V
T
R
E
R
D
--
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
---
M
H
----
I
Q
I
T
D
F
G
T
---
A
K-
V
-
L
--
S
-
P
---------A--
R
A
--
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
-
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
----
G
N
E
Y
L
I
F
Q
K
I
--
I
K
---
L
E
----
Y
D
F
--
P
----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
-----------------------------------------------
538
Blastp_CBE
50.87
36%
-34
- C1 -
-
3E87
6.7
-
AKT2_HUMAN
B:
[3-278]
--------------------------------------------------------------------------------------------------------------------------------
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
-
R
E
---
K
---
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
-
D
E
-
V
A
H
T
V
T
-
E
S
R
--
V
L
Q
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
---
G
H
----
I
K
I
T
D
F
G
L
---
C
--
K
-
E
--
G
-
I
-
S
--
D
---
G
---
A
T
--
M
K
F
----
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-
Y
G
-
R
-
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
----
Q
D
H
E
R
L
F
E
L
I
--
L
M
---
E
E
----
I
R
F
--
P
----
R
T
--
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
LGGGP
S
-----
D
A
K
-
E
V
M
E
H
R
F
F
-
L
S
---------------------
509
Blastp_CBE
50.75
32%
-36
- C1 -
-
2GNF
4.8
-
KAPCA_BOVIN
A:
[40-301]
---------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
-
K
H
---
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
-
Q
K
V
V
-
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
--
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
I
-
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
---
G
Y
----
I
K
V
A
D
F
G
F
---
A
--
K
-
R
--
V
-
K
-
G
----------
R
T
--
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-
Y
N
-
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
----
D
Q
P
I
Q
I
Y
E
K
I
--
V
S
---
G
K
----
V
R
F
--
P
----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
FGNLK
N
-----
G
V
N
-
D
I
K
N
H
K
W
F
-
A
T
T
D
-------------------
352
Blastp_CBE
50.47
37%
-75
- C1 -
-
3HRC
5.4
-
PDPK1_HUMAN
A:
[32-276]
----------------------------------------------------------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
-
R
E
---
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
-
R
H
I
I
-
K
-
E
N
-
K
V
P
Y
V
T
R
E
R
D
--
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
---
M
H
----
I
Q
I
T
D
F
G
T
---
A
K-
V
-
L
--
S
-
P
---------A--
R
A
--
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
-
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
----
G
N
E
G
L
I
F
A
K
I
--
I
K
---
L
E
----
Y
D
F
--
P
----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
-----------------------------------------------
539
Blastp_CBE
50.46
36%
-35
- C1 -
-
3E87
6.4
-
AKT2_HUMAN
A:
[3-278]
--------------------------------------------------------------------------------------------------------------------------------
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
-
R
E
---
K
---
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
-
D
E
-
V
A
H
T
V
T
-
E
S
R
--
V
L
Q
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
---
G
H
----
I
K
I
T
D
F
G
L
---
C
--
K
-
E
--
G
-
I
-
S
--
D
---
G
---
A
T
--
M
K
F
----
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-
Y
G
-
R
-
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
----
Q
D
H
E
R
L
F
E
L
I
--
L
M
---
E
E
----
I
R
F
--
P
----
R
T
--
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
LGGGP
S
-----
D
A
K
-
E
V
M
E
H
R
F
F
-
L
S
---------------------
504
Blastp_CBE
50.42
32%
-31
- C1 -
-
3OVV
3.3
-
KAPCA_HUMAN
A:
[41-302]
---------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
---
K
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
-
Q
K
V
V
-
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
--
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
---
G
Y
----
I
Q
V
T
D
F
G
F
---
A
--
K
-
R
--
V
-
K
-
G
----------
R
T
--
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-
Y
N
-
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
----
D
Q
P
I
Q
I
Y
E
K
I
--
V
S
---
G
K
----
V
R
F
--
P
----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
FGNLK
N
-----
G
V
N
-
D
I
K
N
H
K
W
F
-
A
T
T
D
-------------------
386
Blastp_CBE
50.09
37%
3
- C1 -
-
4L42
6.9
-
KS6B1_HUMAN
A:
[18-299]
----------------------------------------------------------------------------------------------------------------------------------
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
-
R
K
VTG
A
---
N
T
G
K
I
F
A
M
K
V
L
K
K
-
A
M
I
V
-
R
N
A
K
-
D
T
A
H
T
K
A
E
R
N
--
I
L
E
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
-
G
I
-
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
---
G
H
----
V
K
L
T
D
F
G
L
CKE
S
--
I
-
H
--
D
-
G
-
T
--
V
---
T
---
H
T
----
F
----
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
-
H
N
-
R
-
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
----
E
N
R
K
K
T
I
D
K
I
--
L
K
---
C
K
----
L
N
L
--
P
----
P
Y
--
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
-----------------------------------------------
498
Blastp_CBE
50.00
32%
-33
- C1 -
-
4UJ2
6.7
-
KAPCA_HUMAN
A:
[41-302]
---------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
---
K
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
-
Q
K
V
V
-
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
--
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
---
G
Y
----
I
Q
V
T
D
F
G
F
---
A
--
K
-
R
--
V
-
K
-
G
----------
R
T
--
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-
Y
N
-
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
----
D
Q
P
I
Q
I
Y
E
K
I
--
V
S
---
G
K
----
V
R
F
--
P
----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
FGNLK
N
-----
G
V
N
-
D
I
K
N
H
K
W
F
-
A
T
T
D
-------------------
384
Blastp_CBE
49.99
37%
-1
- C1 -
-
3WE4
7.0
-
KS6B1_HUMAN
A:
[19-265]
----------------------------------------------------------------------------------------------------------------------------------
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
-
R
K
VTG
A
---
N
T
G
K
I
F
A
M
K
V
L
K
K
-
A
M
I
V
-
R
N
A
K
-
D
T
A
H
T
K
A
E
R
N
--
I
L
E
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
-
G
I
-
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
---
G
H
----
V
K
L
T
D
F
G
L
CKE
S
--
I
-
H
--
D
------
V
--------
T
--
H
-
F
----
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
-
H
N
-
R
-
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
----
E
N
R
K
K
T
I
D
K
I
--
L
K
---
C
K
----
L
N
L
--
P
----
P
Y
--
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
-----------------------------------------------
500
Blastp_CBE
49.93
32%
-30
- C1 -
-
3POO
3.3
-
KAPCA_HUMAN
A:
[41-306]
---------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
---
K
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
-
Q
K
V
V
-
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
--
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
---
G
Y
----
I
Q
V
T
D
F
G
F
---
A
--
K
-
R
--
V
-
K
-
G
----------
R
T
--
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-
Y
N
-
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
----
D
Q
P
I
Q
I
Y
E
K
I
--
V
S
---
G
K
----
V
R
F
--
P
----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
FGNLK
N
-----
G
V
N
-
D
I
K
N
H
K
W
F
-
A
T
T
D
-------------------
475
Blastp_CBE
49.92
33%
-31
- C1 -
-
3L9M
6.8
-
KAPCA_HUMAN
B:
[41-302]
---------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
---
K
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
-
Q
K
V
V
-
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
--
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
---
G
Y
----
I
K
V
T
D
F
G
F
---
A
--
K
-
R
--
V
-
K
-
G
----------
R
T
--
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-
Y
N
-
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
----
D
Q
P
I
Q
I
Y
E
K
I
--
V
S
---
G
K
----
V
R
F
--
P
----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
FGNLK
N
-----
G
V
N
-
D
I
K
N
H
K
W
F
-
A
T
T
D
-------------------
489
Blastp_CBE
49.73
32%
-34
- C1 -
-
2GNL
5.3
-
KAPCA_BOVIN
A:
[40-301]
---------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
-
K
H
---
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
-
Q
K
V
V
-
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
--
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
---
G
Y
----
I
K
V
A
D
F
G
F
---
A
--
K
-
R
--
V
-
K
-
G
----------
R
T
--
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-
Y
N
-
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
----
D
Q
P
I
Q
I
Y
E
K
I
--
V
S
---
G
K
----
V
R
F
--
P
----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
FGNLK
N
-----
G
V
N
-
D
I
K
N
H
K
W
F
-
A
T
T
D
-------------------
476
Blastp_CBE
49.51
33%
-33
- C1 -
-
3L9M
6.6
-
KAPCA_HUMAN
A:
[41-302]
---------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
---
K
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
-
Q
K
V
V
-
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
--
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
---
G
Y
----
I
K
V
T
D
F
G
F
---
A
--
K
-
R
--
V
-
K
-
G
----------
R
T
--
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-
Y
N
-
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
----
D
Q
P
I
Q
I
Y
E
K
I
--
V
S
---
G
K
----
V
R
F
--
P
----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
FGNLK
N
-----
G
V
N
-
D
I
K
N
H
K
W
F
-
A
T
T
D
-------------------
490
Blastp_CBE
49.38
32%
-28
- C1 -
-
2GNJ
5.1
-
KAPCA_BOVIN
A:
[40-301]
---------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
-
K
H
---
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
-
Q
K
V
V
-
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
--
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
---
G
Y
----
I
K
V
A
D
F
G
F
---
A
--
K
-
R
--
V
-
K
-
G
----------
R
T
--
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-
Y
N
-
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
----
D
Q
P
I
Q
I
Y
E
K
I
--
V
S
---
G
K
----
V
R
F
--
P
----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
FGNLK
N
-----
G
V
N
-
D
I
K
N
H
K
W
F
-
A
T
T
D
-------------------
529
Blastp_CBE
49.32
32%
-29
- C1 -
-
2VO0
6.8
-
KAPCA_BOVIN
A:
[41-302]
---------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
---
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
-
Q
K
V
V
-
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
--
L
Q
A
-
V
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
---
G
Y
----
I
K
V
T
D
F
G
F
---
A
--
K
-
R
--
V
-
K
-
G
----------
R
T
--
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-
Y
N
-
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
----
D
Q
P
I
Q
I
Y
E
K
I
--
V
S
---
G
K
----
V
R
F
--
P
----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
FGNLK
N
-----
G
V
N
-
D
I
K
N
H
K
W
F
-
A
T
T
D
-------------------
519
Blastp_CBE
48.89
32%
-24
- C1 -
-
6C0U
3.4
-
KAPCA_HUMAN
A:
[44-305]
---------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
---
K
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
-
Q
K
V
V
-
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
--
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
---
G
Y
----
I
Q
V
T
D
F
G
F
---
A
--
K
-
R
--
V
-
K
-
G
----------
R
T
--
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-
Y
N
-
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
----
D
Q
P
I
Q
I
Y
E
K
I
--
V
S
---
G
K
----
V
R
F
--
P
----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
FGNLK
N
-----
G
V
N
-
D
I
K
N
H
K
W
F
-
A
T
T
D
-------------------
381
Blastp_CBE
48.65
37%
2
- C1 -
-
3WF7
6.8
-
KS6B1_HUMAN
A:
[19-265]
----------------------------------------------------------------------------------------------------------------------------------
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
-
R
K
VTG
A
---
N
T
G
K
I
F
A
M
K
V
L
K
K
-
A
M
I
V
-
R
N
A
K
-
D
T
A
H
T
K
A
E
R
N
--
I
L
E
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
-
G
I
-
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
---
G
H
----
V
K
L
T
D
F
G
L
CKE
S
--
I
-
H
--
D
------
V
--------
T
--
H
-
F
----
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
-
H
N
-
R
-
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
----
E
N
R
K
K
T
I
D
K
I
--
L
K
---
C
K
----
L
N
L
--
P
----
P
Y
--
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
-----------------------------------------------
466
Blastp_CBE
48.55
35%
5
- C1 -
-
6C0T
2.7
-
A:
[33-295]
---------------------------------------------------------------------------------------------------------------------------------
L
S
D
F
N
I
I
D
T
L
G
V
G
G
F
G
R
V
E
L
V
-
Q
L
---
K
SE-
E
S
K
-
T
F
A
M
K
I
L
K
K
-
R
H
I
V
-
D
-
T
R
-
Q
Q
E
H
I
R
S
E
K
Q
--
I
M
Q
G
A
H
S
D
F
I
V
R
L
Y
R
T
F
K
D
S
K
Y
L
Y
M
L
M
E
A
C
L
G
G
E
L
W
T
I
L
R
D
R
-
G
S
-
F
E
D
S
T
T
R
F
Y
T
A
C
V
V
E
A
F
A
Y
L
H
S
-
K
G
I
I
Y
R
D
L
K
P
E
N
L
I
L
D
H
R
---
G
Y
----
A
K
L
V
D
F
G
F
---
A
--
K
-
K
--
I
-
G
-
F
--
G
---
K
---
K
T
--
W
-
F
----
C
G
T
P
E
Y
V
A
P
E
I
I
L
N
K
G
-
H
D
-
I
-
S
A
D
Y
W
S
L
G
I
L
M
Y
E
L
L
T
G
S
P
P
F
S
G
PDPM
K
T
Y
N
I
I
L
R
G
I
--
D
M
---
I
E
------
F
--
P
----
K
K
--
I
A
K
N
A
A
N
L
I
K
K
L
C
R
D
N
P
S
E
--
R
LGNLK
N
-----
G
V
K
-
D
I
Q
K
H
K
W
F
------------------------
440
Blastp_CBE
48.52
38%
-69
- C1 -
-
3I7C
6.1
-
?
A:
[32-288]
----------------------------------------------------------------------------------------------------------------------------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
---
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
-
R
Q
V
K
-
Q
-
K
T
-
D
K
E
S
L
L
R
E
V
Q
--
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
---
S
K
DAN-
I
R
I
I
D
F
G
L
---
S
--
T
-
H
--
F
-
E
-
A
--
S
---
K
---
K
K
--
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
-
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
----
A
N
E
Y
D
I
L
K
K
V
--
E
K
---
G
K
----
Y
T
F
EL
P
----
Q
W
KK
V
S
E
S
A
K
D
L
I
-
R
K
L
T
Y
V
P
S
---
R
-----
I
-----
S
A
R
-
D
A
L
D
H
E
W
I
------------------------
474
Blastp_CBE
48.41
33%
-34
- C1 -
-
3L9N
5.7
-
KAPCA_HUMAN
A:
[41-305]
---------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
---
K
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
-
Q
K
V
V
-
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
--
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
---
G
Y
----
I
K
V
T
D
F
G
F
---
A
--
K
-
R
--
V
-
K
-
G
----------
R
T
--
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-
Y
N
-
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
----
D
Q
P
I
Q
I
Y
E
K
I
--
V
S
---
G
K
----
V
R
F
--
P
----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
FGNLK
N
-----
G
V
N
-
D
I
K
N
H
K
W
F
-
A
T
T
D
-------------------
375
Blastp_CBE
48.06
37%
-9
- C1 -
-
4L46
6.7
-
KS6B1_HUMAN
A:
[18-280]
----------------------------------------------------------------------------------------------------------------------------------
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
-
R
K
VTG
A
---
N
T
G
K
I
F
A
M
K
V
L
K
K
-
A
M
I
V
-
R
N
A
K
-
D
T
A
H
T
K
A
E
R
N
--
I
L
E
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
-
G
I
-
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
---
G
H
----
V
K
L
T
D
F
G
L
CKE
S
--
I
-
H
--
D
--------------
H
T
----
F
----
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
-
H
N
-
R
-
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
----
E
N
R
K
K
T
I
D
K
I
--
L
K
---
C
K
----
L
N
L
--
P
----
P
Y
--
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
-----------------------------------------------
373
Blastp_CBE
47.90
37%
-3
- C1 -
-
4L44
7.0
-
KS6B1_HUMAN
A:
[18-275]
----------------------------------------------------------------------------------------------------------------------------------
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
-
R
K
VTG
A
---
N
T
G
K
I
F
A
M
K
V
L
K
K
-
A
M
I
V
-
R
N
A
K
-
D
T
A
H
T
K
A
E
R
N
--
I
L
E
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
-
G
I
-
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
---
G
H
----
V
K
L
T
D
F
G
L
CKE
S
--
I
-
H
-----------------
H
T
----
F
----
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
-
H
N
-
R
-
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
----
E
N
R
K
K
T
I
D
K
I
--
L
K
---
C
K
----
L
N
L
--
P
----
P
Y
--
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
-----------------------------------------------
125
Blastp_CBE
47.51
100%
-110
- C1 -
-
2NP8
7.7
-
AURKA_HUMAN
A:
[8-166]
------------------------------------------------------------------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
---
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
-
A
Q
L
E
-
K
-
A
G
-
V
E
H
Q
L
R
R
E
V
E
--
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
---
S
--
V
-
H
--
A
-
P
-
S
--
S
---
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
426
Blastp_CBE
46.98
35%
-10
- C1 -
-
5D9K
5.8
-
KS6A3_HUMAN
B:
[32-281]
------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
-
K
K
ISG
S
---
D
A
R
Q
L
Y
A
M
K
V
L
K
K
-
A
T
L
K
V
R
-
D
R
-
V
R
T
K
M
E
R
D
I
L
--
V
E
--
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
-
V
M
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
---
G
H
----
I
K
L
T
D
F
G
L
---
S
--
K
-
E
----------------------------
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
-
H
T
-
Q
-
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
----
K
D
R
K
E
T
M
T
M
I
--
L
K
---
A
K
----
L
G
M
--
P
----
Q
F
--
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
-----------------------------------------------
427
Blastp_CBE
45.76
35%
-14
- C1 -
-
5D9K
6.2
-
KS6A3_HUMAN
A:
[32-280]
------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
-
K
K
ISG
S
---
D
A
R
Q
L
Y
A
M
K
V
L
K
K
-
A
T
L
K
V
R
-
D
R
-
V
R
T
K
M
E
R
D
I
L
--
V
E
--
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
-
V
M
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
---
G
H
----
I
K
L
T
D
F
G
L
---
S
--
K
------------------------------
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
-
H
T
-
Q
-
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
----
K
D
R
K
E
T
M
T
M
I
--
L
K
---
A
K
----
L
G
M
--
P
----
Q
F
--
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
-----------------------------------------------
431
Blastp_CBE
45.47
35%
17
- C1 -
-
4NUS
7.2
-
KS6A3_HUMAN
A:
[32-280]
------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
-
K
K
ISG
S
---
D
A
R
Q
L
Y
A
M
K
V
L
K
K
-
A
T
L
K
V
R
-
D
R
-
V
R
T
K
M
E
R
D
I
L
--
V
E
--
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
-
V
M
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
---
G
H
----
I
K
L
T
D
F
G
L
---
S
--
K
-
E
--
S
-
I
-
D
--
H
---
E
---
K
K
AY
S
-
F
----
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
-
H
T
-
Q
-
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
----
K
D
R
K
E
T
M
T
M
I
--
L
K
---
A
K
----
L
G
M
--
P
----
Q
F
--
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
-----------------------------------------------
421
Blastp_CBE
45.47
36%
-11
- C1 -
-
6G78
6.1
-
KS6A6_HUMAN
B:
[31-273]
------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
-
R
K
---
K
TGP
D
A
G
Q
L
Y
A
M
K
V
L
K
K
-
A
S
L
K
V
R
-
D
---------
D
I
L
--
V
E
--
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
E
-
V
L
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
E
I
---
G
H
----
I
K
L
T
D
F
G
L
---
S
--
K
-
E
--
S
-
V
------------------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
-
H
S
-
Q
-
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
----
K
D
R
N
E
T
M
N
M
I
--
L
K
---
A
K
----
L
G
M
--
P
----
Q
F
--
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
-----------------------------------------------
422
Blastp_CBE
44.64
36%
-7
- C1 -
-
6G78
7.2
-
KS6A6_HUMAN
A:
[31-273]
------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
-
R
K
---
K
TGP
D
A
G
Q
L
Y
A
M
K
V
L
K
K
-
A
S
L
K
V
R
-
D
---------
D
I
L
--
V
E
--
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
E
-
V
L
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
E
I
---
G
H
----
I
K
L
T
D
F
G
L
---
S
--
K
-
E
--
S
-
V
-
D
--
Q
-------------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
-
H
S
-
Q
-
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
----
K
D
R
N
E
T
M
N
M
I
--
L
K
---
A
K
----
L
G
M
--
P
----
Q
F
--
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
-----------------------------------------------
378
Blastp_CBE
44.64
37%
-12
- C1 -
-
3A62
8.8
-
KS6B1_HUMAN
A:
[17-263]
----------------------------------------------------------------------------------------------------------------------------------
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
-
R
K
VTG
A
---
N
T
G
K
I
F
A
M
K
V
L
K
-----------------
K
A
E
R
N
--
I
L
E
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
-
G
I
-
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
---
G
H
----
V
K
L
T
D
F
G
L
CKE-----------------------------
F
----
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
-
H
N
-
R
-
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
----
E
N
R
K
K
T
I
D
K
I
--
L
K
---
C
K
----
L
N
L
--
P
----
P
Y
--
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
-----------------------------------------------
524
Blastp_CBE
44.57
34%
-35
- C1 -
-
3NX8
3.6
-
KAPCA_HUMAN
A:
[41-279]
---------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
---
K
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
-
Q
K
V
V
-
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
--
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
---
G
Y
----
I
Q
V
T
D
F
G
F
---
A
--
K
-
R
--
V
-
K
-
G
----------
R
T
--
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-
Y
N
-
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
----
D
Q
P
I
Q
I
Y
E
K
I
--
V
S
---
G
K
----
V
R
F
--
P
----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
-----------------------------------------------
415
Blastp_CBE
44.51
36%
9
- C1 -
-
6G77
6.4
-
KS6A6_HUMAN
B:
[31-273]
------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
-
R
K
---
K
TGP
D
A
G
Q
L
Y
A
M
K
V
L
K
K
-
A
S
L
K
V
R
-
D
---------
D
I
L
--
V
E
--
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
E
-
V
L
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
E
I
---
G
H
----
I
K
L
T
D
F
G
L
---
S
--
K
-
E
--
S
-
V
-
D
--
Q
---
E
---
K
K
AY
S
-
F
----
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
-
H
S
-
Q
-
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
----
K
D
R
N
E
T
M
N
M
I
--
L
K
---
A
K
----
L
G
M
--
P
----
Q
F
--
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
-----------------------------------------------
416
Blastp_CBE
44.49
36%
7
- C1 -
-
6G77
6.6
-
KS6A6_HUMAN
A:
[31-273]
------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
-
R
K
---
K
TGP
D
A
G
Q
L
Y
A
M
K
V
L
K
K
-
A
S
L
K
V
R
-
D
---------
D
I
L
--
V
E
--
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
E
-
V
L
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
E
I
---
G
H
----
I
K
L
T
D
F
G
L
---
S
--
K
-
E
--
S
-
V
-
D
--
Q
---
E
---
K
K
AY
S
-
F
----
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
-
H
S
-
Q
-
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
----
K
D
R
N
E
T
M
N
M
I
--
L
K
---
A
K
----
L
G
M
--
P
----
Q
F
--
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
-----------------------------------------------
428
Blastp_CBE
44.28
35%
-11
- C1 -
-
5D9L
4.9
-
KS6A3_HUMAN
A:
[32-274]
------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
-
K
K
ISG
S
---
D
A
R
Q
L
Y
A
M
K
V
L
K
K
-
A
T
L
K
V
R
-
D
R
-
V
R
T
K
M
E
R
D
I
L
--
V
E
--
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
-
V
M
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
---
G
H
----
I
K
L
T
D
F
G
L
---
S
--
K
-
E
-----------------------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
-
H
T
-
Q
-
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
----
K
D
R
K
E
T
M
T
M
I
--
L
K
---
A
K
----
L
G
M
--
P
----
Q
F
--
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
-----------------------------------------------
371
Blastp_CBE
42.59
37%
-5
- C1 -
-
3A60
8.1
-
KS6B1_HUMAN
A:
[17-263]
----------------------------------------------------------------------------------------------------------------------------------
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
-
R
K
VTG
A
---
N
T
G
K
I
F
A
M
K
V
L
K
K
-
A
M
-------------
K
A
E
R
N
--
I
L
E
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
-
G
I
-
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
---
G
H
----
V
K
L
T
D
F
G
L
CKE------------------------------------
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
-
H
N
-
R
-
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
----
E
N
R
K
K
T
I
D
K
I
--
L
K
---
C
K
----
L
N
L
--
P
----
P
Y
--
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
-----------------------------------------------
369
Blastp_CBE
42.38
37%
1
- C1 -
-
3A61
7.9
-
KS6B1_HUMAN
A:
[17-263]
----------------------------------------------------------------------------------------------------------------------------------
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
-
R
K
VTG
A
---
N
T
G
K
I
F
A
M
K
V
L
------------------
K
A
E
R
N
--
I
L
E
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
-
G
I
-
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
---
G
H
----
V
K
L
T
D
F
G
---------------------------------------
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
-
H
N
-
R
-
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
----
E
N
R
K
K
T
I
D
K
I
--
L
K
---
C
K
----
L
N
L
--
P
----
P
Y
--
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
-----------------------------------------------
432
Blastp_CBE
41.78
35%
-10
- C1 -
-
3G51
6.6
-
KS6A3_MOUSE
A:
[26-268]
------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
-
K
K
ISG
S
---
D
A
R
Q
L
Y
A
M
K
V
L
K
K
-
A
T
L
K
V-----------
R
D
I
L
--
V
E
--
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
-
V
M
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
---
G
H
----
I
K
L
T
D
F
G
L
---
S
--
K
-
E
--
S
-
I
-------------------------
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
-
H
T
-
Q
-
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
----
K
D
R
K
E
T
M
T
M
I
--
L
K
---
A
K
----
L
G
M
--
P
----
Q
F
--
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
-----------------------------------------------
453
Blastp_CBE
41.00
36%
-6
- C1 -
-
2Z7R
8.5
-
KS6A1_HUMAN
A:
[30-272]
------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
-
R
K
---
V
TRP
D
S
G
H
L
Y
A
M
K
V
L
K
K
-
A
T
L
K
------
V
-----------
I
L
A
D
V
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
-
V
M
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
---
G
H
----
I
K
L
T
D
F
G
L
---
S
--
K
-
E
-----------------------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
Q
G
-
H
S
-
H
-
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
Q
G
----
K
D
R
K
E
T
M
T
L
I
--
L
K
---
A
K
----
L
G
M
--
P
----
Q
F
--
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
--
R
-----------------------------------------------
379
Blastp_CBE
40.97
37%
7
- C1 -
-
3WF9
6.1
-
KS6B1_HUMAN
A:
[19-265]
----------------------------------------------------------------------------------------------------------------------------------
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
-
R
K
VTG
A
---
N
T
G
K
I
F
A
M
K
V
L
K
K
-
A
M
I
V
-
R
N
A
K
-
D
T
A
H
T
K
A
E
R
N
--
I
L
E
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
-
G
I
-
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
---
G
H
----
V
K
L
T
D
F
G
L
CKE
S
--
I
-
H
--
D
-
G
-
T
--
V
--------
T
--
H
-
F
----
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
-
H
N
-
R
-
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
----
E
N
R
K
K
T
I
D
K
I
--
L
K
---
C
K
----
L
N
L
--
P
----
P
Y
--
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
-----------------------------------------------
454
Blastp_CBE
40.59
36%
-14
- C1 -
-
2Z7Q
4.9
-
KS6A1_HUMAN
A:
[30-272]
------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
-
R
K
---
V
TRP
D
S
G
H
L
Y
A
M
K
V
L
-------------------------
I
L
A
D
V
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
-
V
M
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
---
G
H
----
I
K
L
T
D
F
G
L
---
S
--
K
-
E
-----------------------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
Q
G
-
H
S
-
H
-
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
Q
G
----
K
D
R
K
E
T
M
T
L
I
--
L
K
---
A
K
----
L
G
M
--
P
----
Q
F
--
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
--
R
-----------------------------------------------
413
Blastp_CBE
40.46
36%
-17
- C1 -
-
6G76
4.7
-
KS6A6_HUMAN
B:
[31-273]
------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
-
R
K
---
K
TGP
D
A
G
Q
L
Y
A
M
K
V
L
K
K
-
A
S
L
K
------
V
---------RD
I
L
V
E
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
--
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
E
-
V
L
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
E
I
---
G
H
----
I
K
L
T
D
F
G
L
---
S
--
K
-
E
--
S
V
D
--------------------------
V
E
Y
M
A
P
E
V
V
N
R
R
G
-
H
S
-
Q
-
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
----
K
D
R
N
E
T
-----------------
L
G
M
--
P
----
Q
F
--
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
-----------------------------------------------
414
Blastp_CBE
38.11
36%
6
- C1 -
-
6G76
6.2
-
KS6A6_HUMAN
A:
[31-273]
------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
-
R
K
---
K
TGP
D
A
G
Q
L
Y
A
M
K
V
L
K
K
-
A
S
L
K
------
V
R
D
-------D-
I
L
V
E
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
E
-
V
L
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
E
I
---
G
H
----
I
K
L
T
D
F
G
L
---
S
--
K
-
E
--
S
V
D
-
Q
--
E
---
K
---
K
A
--
Y
-
F
----
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
-
H
S
-
Q
-
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
----
K
D
R
N
E
T
M
N
M
I
--
L
K
---
A
K
----
L
G
M
--
P
----
Q
F
--
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
-----------------------------------------------
382
Blastp_CBE
37.66
37%
9
- C1 -
-
3WF6
6.1
-
KS6B1_HUMAN
A:
[19-265]
----------------------------------------------------------------------------------------------------------------------------------
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
-
R
K
VTG
A
---
N
T
G
K
I
F
A
M
K
V
L
K
K
---------------
T
K
A
E
R
N
--
I
L
E
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
-
G
I
-
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
---
G
H
----
V
K
L
T
D
F
G
L
CKE
S
--
I
-
H
--
D
-
G
-
T
--
V
--------
T
--
H
-
F
----
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
-
H
N
-
R
-
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
----
E
N
R
K
K
T
I
D
K
I
--
L
K
---
C
K
----
L
N
L
--
P
----
P
Y
--
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
-----------------------------------------------
366
Blastp_CBE
37.43
37%
1
- C1 -
-
4RLO
8.0
-
KS6B1_HUMAN
B:
[5-251]
----------------------------------------------------------------------------------------------------------------------------------
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
-
R
K
VTG
A
---
N
T
G
K
I
F
A
M
K
V
L
K
K
----------------------------
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
-
G
I
-
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
---
G
H
----
V
K
L
T
D
F
G
L
CKE
S
--
I
--------------------------------
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
-
H
N
-
R
-
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
----
E
N
R
K
K
T
I
D
K
I
--
L
K
---
C
K
----
L
N
L
--
P
----
P
Y
--
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
-----------------------------------------------
383
Blastp_CBE
37.38
37%
4
- C1 -
-
3WF5
6.0
-
KS6B1_HUMAN
A:
[19-265]
----------------------------------------------------------------------------------------------------------------------------------
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
-
R
K
VTG
A
---
N
T
G
K
I
F
A
M
K
V
L
K
K
---------------
T
K
A
E
R
N
--
I
L
E
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
-
G
I
-
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
---
G
H
----
V
K
L
T
D
F
G
L
CKE
S
--
I
-
H
--
D
-
G
-
T
--
V
--------
T
--
H
-
F
----
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
-
H
N
-
R
-
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
----
E
N
R
K
K
T
I
D
K
I
--
L
K
---
C
K
----
L
N
L
--
P
----
P
Y
--
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
-----------------------------------------------
425
Blastp_CBE
37.29
35%
16
- C1 -
-
4EL9
7.5
-
KS6A3_MOUSE
A:
[27-269]
------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
-
K
K
ISG
S
---
D
A
R
Q
L
Y
A
M
K
V
L
K
K
-
A
T
L
K
V
R
-
D
R
-
V
-----
R
D
I
L
--
V
E
--
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
-
V
M
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
---
G
H
----
I
K
L
T
D
F
G
L
---
S
--
K
-
E
--
S
----------
E
---
K
K
AY
S
-
F
----
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
-
H
T
-
Q
-
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
----
K
D
R
K
E
T
M
T
M
I
--
L
K
---
A
K
----
L
G
M
--
P
----
Q
F
--
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
-----------------------------------------------
424
Blastp_CBE
37.17
35%
16
- C1 -
-
4GUE
7.8
-
KS6A3_MOUSE
A:
[27-269]
------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
-
K
K
ISG
S
---
D
A
R
Q
L
Y
A
M
K
V
L
K
K
-
A
T
L
K
V
R
-
D
R
-
V
--------
L
--
V
E
--
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
-
V
M
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
---
G
H
----
I
K
L
T
D
F
G
L
---
S
--
K
---------------
E
---
K
K
AY
S
-
F
----
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
-
H
T
-
Q
-
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
----
K
D
R
K
E
T
M
T
M
I
--
L
K
---
A
K
----
L
G
M
--
P
----
Q
F
--
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
-----------------------------------------------
370
Blastp_CBE
37.14
37%
-2
- C1 -
-
3A60
8.5
-
KS6B1_HUMAN
B:
[17-263]
----------------------------------------------------------------------------------------------------------------------------------
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
-
R
K
VTG
A
---
N
T
G
K
I
F
A
M
K
V
L
K
K
----------------------------
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
-
G
I
-
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
---
G
H
----
V
K
L
T
D
F
G
L
CKE
S
---------------------------------
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
-
H
N
-
R
-
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
----
E
N
R
K
K
T
I
D
K
I
--
L
K
---
C
K
----
L
N
L
--
P
----
P
Y
--
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
-----------------------------------------------
423
Blastp_CBE
36.45
35%
16
- C1 -
-
3UBD
5.9
-
KS6A3_MOUSE
A:
[26-268]
------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
-
K
K
ISG
S
---
D
A
R
Q
L
Y
A
M
K
V
L
K
K
-
A
T
L
K
V
R
-
D
R
-
V
------
D
I
L
--
V
E
--
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
-
V
M
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
---
G
H
----
I
K
L
T
D
F
G
L
---
S
--
K
---------------
E
---
K
K
AY
S
-
F
----
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
-
H
T
-
Q
-
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
----
K
D
R
K
E
T
M
T
M
I
--
L
K
---
A
K
----
L
G
M
--
P
----
Q
F
--
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
-----------------------------------------------