@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Screening
Virtual Screening Score
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : AURKB_HUMAN: (2020-09-04 )
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
Atome Classification :
(415 SA)
.........10........20........30........40........50........60.......----.70...---.....80........90.....---.---.-.100........110.-.-.-....-120........130.......140.......150.......160.......170........180.......190.-..-....200.....---..210-.---..---......220--.---.-..--.-.-.--..--230----.-.----......240.......250.-.......260.......270.......280......---..290..----.----.....300.......310....-----...320----....------.-----------....330----........340..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(pKd)
(pKd)
(Uniprot)
MAQKENSYPWPYGRQTAP
S
G
L
S
T
L
P
Q
R
V
L
RKEPVTPS
A
L
V
L
M
SRSNVQPTAAP
G
Q
K
V
MENSSG
T
P
D
I
L
----
T
R
H
F
T
I---DDFEIGRPLGKGKFG
N
V
Y
L
A
RE---K---K-S
H
F
-
I
V
A
L
K
V
L
F
K
S
Q
I
-
E
-
K
-
E
G
V
E
-
H
-
Q
L
R
R
E
I
E
I
Q
A
HLHH
P
N
I
L
R
L
Y
N
Y
F
YDR
R
R
I
Y
L
I
L
E
YAP
R
G
E
L
Y
K
E
L
Q
K
SCT-F
D
E
Q
R
T
A
T
I
M
E
E
L
A
D
A
L
M
Y
CHG-
K
K
-
V
I
H
RDIKPE
N
L
L
---
L
GL---K---G
E
---
L
K
I
A
D
FG----W---S-VH--A-P-
S
--
L
R
--
R
-K----T-M----CGTLDYL
P
P
E
M
I
EGRMHN-E-KVD
L
W
C
I
G
V
L
C
Y
E
L
LVGNPPFESASH
N
E
-
T
Y
R
R
I
V
K
---
V
D
L
-KFP----A----SVPM
G
A
Q
D
L
I
S
K
L
L
RHNPSERL-----P
L
A
Q------VSAH------P-----------WVRANS-----RRVL
P
P
S
A
L
Q
SVA
3
PsiBlast_PDB
91.88
83%
-130
- C1 -
-
6GR9
8.0
-
AURKC_HUMAN
A:
[6-274]
--------------------------------------------------------------------------
R
L
T
V
---
D
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
L
---
K
---
E
-
S
H
F
-
I
V
A
L
K
V
L
F
K
S
Q
I
-
E
-
K
-
E
G
L
E
-
H
-
Q
L
R
R
E
I
E
I
Q
A
H
L
Q
H
P
N
I
L
R
L
Y
N
Y
F
H
D
A
R
R
V
Y
L
I
L
E
Y
A
P
R
G
E
L
Y
K
E
L
Q
K
S
D
K
-
L
D
E
Q
R
T
A
T
I
I
E
E
L
A
D
A
L
T
Y
C
H
D
-
K
K
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
F
---
R
---
G
E
---
V
K
I
A
D
F
G
----
W
---
S
-
V
H
--
T
-
P
-
S
--
L
R
--
R
-
K
----
T
-
M
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
T
Y
D
-
E
-
K
V
D
L
W
C
I
G
V
L
C
Y
E
L
L
V
G
Y
P
P
F
E
S
A
S
H
S
E
-
T
Y
R
R
I
L
K
---
V
D
V
-
R
F
P
----
L
----
S
M
P
L
G
A
R
D
L
I
S
R
L
L
R
Y
Q
P
L
E
R
L
-----
P
L
A
Q
------
I
L
K
H
------
P
-----------
W
V
Q
A
H
S
-----
R
R
V
L
P
P
C
A
-----
2
PsiBlast_PDB
91.50
83%
-113
- C1 -
-
6GR8
10.9
-
AURKC_HUMAN
A:
[4-272]
------------------------------------------------------------------------
S
R
R
L
T
V
---
D
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
L
---
K
---
E
-
S
H
F
-
I
V
A
L
K
V
L
F
K
S
Q
I
-
E
-
K
-
E
G
L
E
-
H
-
Q
L
R
R
E
I
E
I
Q
A
H
L
Q
H
P
N
I
L
R
L
Y
N
Y
F
H
D
A
R
R
V
Y
L
I
L
E
Y
A
P
R
G
E
L
Y
K
E
L
Q
K
S
D
K
-
L
D
E
Q
R
T
A
T
I
I
E
E
L
A
D
A
L
T
Y
C
H
D
-
K
K
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
F
---
R
---
G
E
---
V
K
I
A
D
F
G
----
W
---
S
-
V
H
--
T
-
P
-
S
--
L
R
--
R
-
K
----
T
-
M
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
T
Y
D
-
E
-
K
V
D
L
W
C
I
G
V
L
C
Y
E
L
L
V
G
Y
P
P
F
E
S
A
S
H
S
E
-
T
Y
R
R
I
L
K
---
V
D
V
-
R
F
P
----
L
----
S
M
P
L
G
A
R
D
L
I
S
R
L
L
R
Y
Q
P
L
E
R
L
-----
P
L
A
Q
------
I
L
K
H
------
P
-----------
W
V
Q
A
H
S
-----
R
R
V
L
P
P
-------
1
PsiBlast_PDB
89.53
99%
-129
- C1 -
-
4AF3
7.9
-
AURKB_HUMAN
A:
[18-286]
-------------------------------------------------------------------------
R
H
F
T
I
---
D
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
K
-
S
H
F
-
I
V
A
L
K
V
L
F
K
S
Q
I
-
E
-
K
-
E
G
V
E
-
H
-
Q
L
R
R
E
I
E
I
Q
A
H
L
H
H
P
N
I
L
R
L
Y
N
Y
F
Y
D
R
R
R
I
Y
L
I
L
E
Y
A
P
R
G
E
L
Y
K
E
L
Q
K
S
C
T
-
F
D
E
Q
R
T
A
T
I
M
E
E
L
A
D
A
L
M
Y
C
H
G
-
K
K
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
L
---
K
---
G
E
---
L
K
I
A
D
F
G
------------------------------------------
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
N
-
E
-
K
V
D
L
W
C
I
G
V
L
C
Y
E
L
L
V
G
N
P
P
F
E
S
A
S
H
N
E
-
T
Y
R
R
I
V
K
---
V
D
L
-
K
F
P
----
A
----
S
V
P
T
G
A
Q
D
L
I
S
K
L
L
R
H
N
P
S
E
R
L
-----
P
L
A
Q
------
V
S
A
H
------
P
-----------
W
V
R
A
N
S
-----
R
R
V
L
P
P
S
------
8
PsiBlast_PDB
89.26
80%
-113
- C1 -
-
2VGO
6.9
-
AUKBA_XENLA
A:
[10-276]
--------------------------------------------------------------------------
K
F
T
I
---
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
N
K
F
-
I
M
A
L
K
V
L
F
K
S
Q
L
-
E
-
K
-
E
G
V
E
-
H
-
Q
L
R
R
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Q
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P
N
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D
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K
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L
M
L
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P
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K
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Q
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R
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F
D
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A
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F
M
E
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L
A
D
A
L
H
Y
C
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E
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R
K
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V
I
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R
D
I
K
P
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N
L
L
---
M
G
Y
---
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---
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E
---
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K
I
A
D
F
G
----
W
---
S
-
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--
A
-
P
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S
--
L
R
--
R
-
R
----
T
-
M
----
C
G
T
L
D
Y
L
P
P
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M
I
E
G
K
T
H
D
-
E
-
K
V
D
L
W
C
A
G
V
L
C
Y
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F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
-
T
H
R
R
I
V
N
---
V
D
L
-
K
F
P
----
P
----
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
K
G
------
V
M
E
H
------
P
-----------
W
V
K
A
N
S
-----
R
R
V
L
P
P
-------
557
HHSearch
89.21
80%
-114
- C1 -
-
4C2V
8.0
-
AUKBA_XENLA
B:
[11-280]
-------------------------------------------------------------------------
R
K
F
T
I
---
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
N
K
F
-
I
M
A
L
K
V
L
F
K
S
Q
L
-
E
-
K
-
E
G
V
E
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H
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Q
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R
E
I
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I
Q
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A
D
A
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C
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E
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R
K
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V
I
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D
I
K
P
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N
L
L
---
M
G
Y
---
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---
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E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
L
R
--
R
-
R
----
T
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M
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
-
E
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K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
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S
P
S
H
T
E
-
T
H
R
R
I
V
N
---
V
D
L
-
K
F
P
----
P
----
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
K
G
------
V
M
E
H
------
P
-----------
W
V
K
A
N
S
-----
R
R
V
L
P
P
V
Y
-----
6
PsiBlast_PDB
88.79
80%
-112
- C1 -
-
2BFX
-
-
AUKBA_XENLA
A:
[86-353]
-------------------------------------------------------------------------
R
K
F
T
I
---
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
N
K
F
-
I
M
A
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L
F
K
S
Q
L
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E
-
K
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E
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H
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R
R
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S
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L
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N
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Y
F
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K
R
I
Y
L
M
L
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A
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L
Y
K
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L
Q
K
H
G
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Q
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M
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A
D
A
L
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E
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K
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R
D
I
K
P
E
N
L
L
---
M
G
Y
---
K
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
L
R
--
R
-
R
----
T
-
M
----
C
G
T
L
D
Y
L
P
P
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M
I
E
G
K
T
H
D
-
E
-
K
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L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
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D
S
P
S
H
T
E
-
T
H
R
R
I
V
N
---
V
D
L
-
K
F
P
----
P
----
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
K
G
------
V
M
E
H
------
P
-----------
W
V
K
A
N
S
-----
R
R
V
L
P
P
-------
23
Blastp_CBE
88.70
77%
-113
- C1 -
-
4C2V
8.0
-
AUKBA_XENLA
B:
[1-278]
-----------------------------------------------------------
Q
N
T
A
L
A
E
M
P
----
K
R
K
F
T
I
---
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
N
K
F
-
I
M
A
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K
V
L
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K
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Q
L
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E
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K
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E
G
V
E
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H
-
Q
L
R
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E
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L
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P
N
I
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M
Y
N
Y
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R
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M
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A
P
R
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E
L
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Q
K
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F
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E
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A
T
F
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A
D
A
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H
E
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---
M
G
Y
---
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---
G
E
---
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K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
L
R
--
R
-
R
----
T
-
M
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
-
E
-
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
-
T
H
R
R
I
V
N
---
V
D
L
-
K
F
P
----
P
----
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
K
G
------
V
M
E
H
------
P
-----------
W
V
K
A
N
S
-----
R
R
V
L
P
P
-------
25
Blastp_CBE
88.52
80%
-116
- C1 -
-
2VGP
6.0
-
AUKBA_XENLA
B:
[9-276]
-------------------------------------------------------------------------
R
K
F
T
I
---
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
N
K
F
-
I
M
A
L
K
V
L
F
K
S
Q
L
-
E
-
K
-
E
G
V
E
-
H
-
Q
L
R
R
E
I
E
I
Q
S
H
L
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
G
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
-
V
I
H
R
D
I
K
P
E
N
L
L
---
M
G
Y
---
K
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
L
R
--
R
-
R
----
T
-
M
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
-
E
-
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
-
T
H
R
R
I
V
N
---
V
D
L
-
K
F
P
----
P
----
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
K
G
------
V
M
E
H
------
P
-----------
W
V
K
A
N
S
-----
R
R
V
L
P
P
-------
28
Blastp_CBE
88.48
80%
-115
- C1 -
-
4C2W
5.1
-
AUKBA_XENLA
B:
[9-276]
-------------------------------------------------------------------------
R
K
F
T
I
---
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
N
K
F
-
I
M
A
L
K
V
L
F
K
S
Q
L
-
E
-
K
-
E
G
V
E
-
H
-
Q
L
R
R
E
I
E
I
Q
S
H
L
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
G
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
-
V
I
H
R
D
I
K
P
E
N
L
L
---
M
G
Y
---
K
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
L
R
--
R
-
R
----
T
-
M
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
-
E
-
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
-
T
H
R
R
I
V
N
---
V
D
L
-
K
F
P
----
P
----
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
K
G
------
V
M
E
H
------
P
-----------
W
V
K
A
N
S
-----
R
R
V
L
P
P
-------
30
Blastp_CBE
88.42
80%
-114
- C1 -
-
5EYK
9.1
-
AUKBA_XENLA
B:
[6-273]
-------------------------------------------------------------------------
R
K
F
T
I
---
D
D
F
D
I
V
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
N
K
F
-
I
M
A
L
K
V
L
F
K
S
Q
L
-
E
-
K
-
E
G
V
E
-
H
-
Q
L
R
R
E
I
E
I
Q
S
H
L
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
G
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
-
V
I
H
R
D
I
K
P
E
N
L
L
---
M
G
Y
---
K
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
L
R
--
R
-
R
----
T
-
M
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
-
E
-
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
-
T
H
R
R
I
V
N
---
V
D
L
-
K
F
P
----
P
----
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
K
G
------
V
M
E
H
------
P
-----------
W
V
K
A
N
S
-----
R
R
V
L
P
P
-------
556
HHSearch
88.38
81%
-111
- C1 -
-
4C2W
6.0
-
AUKBA_XENLA
A:
[11-276]
---------------------------------------------------------------------------
F
T
I
---
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
N
K
F
-
I
M
A
L
K
V
L
F
K
S
Q
L
-
E
-
K
-
E
G
V
E
-
H
-
Q
L
R
R
E
I
E
I
Q
S
H
L
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
G
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
-
V
I
H
R
D
I
K
P
E
N
L
L
---
M
G
Y
---
K
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
L
R
--
R
-
R
----
T
-
M
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
-
E
-
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
-
T
H
R
R
I
V
N
---
V
D
L
-
K
F
P
----
P
----
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
K
G
------
V
M
E
H
------
P
-----------
W
V
K
A
N
S
-----
R
R
V
L
P
P
-------
7
PsiBlast_PDB
88.25
80%
-116
- C1 -
-
2VGP
5.7
-
AUKBA_XENLA
A:
[11-276]
---------------------------------------------------------------------------
F
T
I
---
D
D
F
D
I
G
R
P
L
G
K
---
G
N
V
Y
L
A
R
E
---
K
---
Q
-
N
K
F
-
I
M
A
L
K
V
L
F
K
S
Q
L
-
E
-
K
-
E
G
V
E
-
H
-
Q
L
R
R
E
I
E
I
Q
S
H
L
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
G
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
-
V
I
H
R
D
I
K
P
E
N
L
L
---
M
G
Y
---
K
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
L
R
--
R
-
R
----
T
-
M
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
-
E
-
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
-
T
H
R
R
I
V
N
---
V
D
L
-
K
F
P
----
P
----
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
K
G
------
V
M
E
H
------
P
-----------
W
V
K
A
N
S
-----
R
R
V
L
P
P
-------
4
PsiBlast_PDB
88.24
77%
-116
- C1 -
-
4B8M
7.5
-
AUKBA_XENLA
A:
[11-277]
--------------------------------------------------------------------------
K
F
T
I
---
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
N
K
F
-
I
M
A
L
K
V
L
F
K
S
Q
L
-
E
-
K
-
E
G
V
E
-
H
-
Q
L
R
R
E
I
E
I
Q
S
H
L
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
G
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
-
V
I
H
R
D
I
K
P
E
N
L
L
---
M
G
Y
---
K
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
L
R
--
R
-
R
----
T
-
M
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
-
E
-
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
-
T
H
R
R
I
V
N
---
V
D
L
-
K
F
P
----
P
----
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
K
G
------
V
M
E
H
------
P
-----------
W
V
K
A
N
S
-----
R
R
V
L
P
P
-------
9
PsiBlast_PDB
88.18
80%
-111
- C1 -
-
3ZTX
7.8
-
AUKBA_XENLA
A:
[10-276]
--------------------------------------------------------------------------
K
F
T
I
---
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
N
K
F
-
I
M
A
L
K
V
L
F
K
S
Q
L
-
E
-
K
-
E
G
V
E
-
H
-
Q
L
R
R
E
I
E
I
Q
S
H
L
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
G
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
-
V
I
H
R
D
I
K
P
E
N
L
L
---
M
G
Y
---
K
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
L
R
--
R
-
R
----
T
-
M
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
-
E
-
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
-
T
H
R
R
I
V
N
---
V
D
L
-
K
F
P
----
P
----
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
K
G
------
V
M
E
H
------
P
-----------
W
V
K
A
N
S
-----
R
R
V
L
P
P
-------
12
PsiBlast_PDB
88.12
80%
-111
- C1 -
-
4C2W
6.0
-
AUKBA_XENLA
A:
[11-276]
---------------------------------------------------------------------------
F
T
I
---
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
N
K
F
-
I
M
A
L
K
V
L
F
K
S
Q
L
-
E
-
K
-
E
G
V
E
-
H
-
Q
L
R
R
E
I
E
I
Q
S
H
L
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
G
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
-
V
I
H
R
D
I
K
P
E
N
L
L
---
M
G
Y
---
K
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
L
R
--
R
-
R
----
T
-
M
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
-
E
-
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
-
T
H
R
R
I
V
N
---
V
D
L
-
K
F
P
----
P
----
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
K
G
------
V
M
E
H
------
P
-----------
W
V
K
A
N
S
-----
R
R
V
L
P
P
-------
14
PsiBlast_PDB
87.94
79%
-107
- C1 -
-
2BFY
8.5
-
AUKBA_XENLA
A:
[9-276]
-------------------------------------------------------------------------
R
K
F
T
I
---
D
D
F
D
I
V
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
N
K
F
-
I
M
A
L
K
V
L
F
K
S
Q
L
-
E
-
K
-
E
G
V
E
-
H
-
Q
L
R
R
E
I
E
I
Q
S
H
L
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
G
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
-
V
I
H
R
D
I
K
P
E
N
L
L
---
M
G
Y
---
K
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
L
R
--
R
-
R
----
T
-
M
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
-
E
-
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
-
T
H
R
R
I
V
N
---
V
D
L
-
K
F
P
----
P
----
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
K
G
------
V
M
E
H
------
P
-----------
W
V
K
A
N
S
-----
R
R
V
L
P
P
-------
5
PsiBlast_PDB
87.91
77%
-112
- C1 -
-
4C2V
8.8
-
AUKBA_XENLA
A:
[12-278]
--------------------------------------------------------------------------
K
F
T
I
---
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
N
K
F
-
I
M
A
L
K
V
L
F
K
S
Q
L
-
E
-
K
-
E
G
V
E
-
H
-
Q
L
R
R
E
I
E
I
Q
S
H
L
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
G
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
-
V
I
H
R
D
I
K
P
E
N
L
L
---
M
G
Y
---
K
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
L
R
--
R
-
R
----
T
-
M
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
-
E
-
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
-
T
H
R
R
I
V
N
---
V
D
L
-
K
F
P
----
P
----
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
K
G
------
V
M
E
H
------
P
-----------
W
V
K
A
N
S
-----
R
R
V
L
P
P
-------
10
PsiBlast_PDB
87.69
77%
-112
- C1 -
-
2VRX
8.1
-
AUKBA_XENLA
A:
[11-277]
--------------------------------------------------------------------------
K
F
T
I
---
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
N
K
F
-
I
M
A
L
K
V
L
F
K
S
Q
L
-
E
-
K
-
E
G
V
E
-
H
-
Q
L
R
R
E
I
E
I
Q
S
H
L
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
G
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
-
V
I
H
R
D
I
K
P
E
N
L
L
---
M
G
Y
---
K
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
L
R
--
R
-
R
----
T
-
M
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
-
E
-
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
-
T
H
R
R
I
V
N
---
V
D
L
-
K
F
P
----
P
----
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
K
G
------
V
M
E
H
------
P
-----------
W
V
K
A
N
S
-----
R
R
V
L
P
P
-------
29
Blastp_CBE
87.39
80%
-108
- C1 -
-
2BFY
8.7
-
AUKBA_XENLA
B:
[9-276]
-------------------------------------------------------------------------
R
K
F
T
I
---
D
D
F
D
I
V
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
N
K
F
-
I
M
A
L
K
V
L
F
K
S
Q
L
-
E
-
K
-
E
G
V
E
-
H
-
Q
L
R
R
E
I
E
I
Q
S
H
L
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
G
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
-
V
I
H
R
D
I
K
P
E
N
L
L
---
M
G
Y
---
K
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
L
R
--
R
-
R
----
T
-
M
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
-
E
-
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
-
T
H
R
R
I
V
N
---
V
D
L
-
K
F
P
----
P
----
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
K
G
------
V
M
E
H
------
P
-----------
W
V
K
A
N
S
-----
R
R
V
L
P
P
-------
22
Blastp_CBE
87.35
78%
-117
- C1 -
-
4B8M
8.1
-
AUKBA_XENLA
B:
[2-277]
-------------------------------------------------------------
T
A
L
A
E
M
P
----
K
R
K
F
T
I
---
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
N
K
F
-
I
M
A
L
K
V
L
F
K
S
Q
L
-
E
-
K
-
E
G
V
E
-
H
-
Q
L
R
R
E
I
E
I
Q
S
H
L
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
G
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
-
V
I
H
R
D
I
K
P
E
N
L
L
---
M
G
Y
---
K
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
L
R
--
R
-
R
----
T
-
M
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
-
E
-
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
-
T
H
R
R
I
V
N
---
V
D
L
-
K
F
P
----
P
----
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
K
G
------
V
M
E
H
------
P
-----------
W
V
K
A
N
S
-----
R
R
V
L
P
P
-------
15
PsiBlast_PDB
87.14
79%
-118
- C1 -
-
5EYK
9.2
-
AUKBA_XENLA
A:
[8-273]
---------------------------------------------------------------------------
F
T
I
---
D
D
F
D
I
V
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
N
K
F
-
I
M
A
L
K
V
L
F
K
S
Q
L
-
E
-
K
-
E
G
V
E
-
H
-
Q
L
R
R
E
I
E
I
Q
S
H
L
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
G
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
-
V
I
H
R
D
I
K
P
E
N
L
L
---
M
G
Y
---
K
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
----------
R
-
R
----
T
-
M
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
-
E
-
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
-
T
H
R
R
I
V
N
---
V
D
L
-
K
F
P
----
P
----
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
K
G
------
V
M
E
H
------
P
-----------
W
V
K
A
N
S
-----
R
R
V
L
P
P
-------
27
Blastp_CBE
87.08
78%
-113
- C1 -
-
2VRX
8.1
-
AUKBA_XENLA
B:
[1-277]
------------------------------------------------------------
N
T
A
L
A
E
M
P
----
K
R
K
F
T
I
---
D
D
F
D
I
G
R
P
L
G
----
G
N
V
Y
L
A
R
E
---
K
---
Q
-
N
K
F
-
I
M
A
L
K
V
L
F
K
S
Q
L
-
E
-
K
-
E
G
V
E
-
H
-
Q
L
R
R
E
I
E
I
Q
S
H
L
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
G
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
-
V
I
H
R
D
I
K
P
E
N
L
L
---
M
G
Y
---
K
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
L
R
--
R
-
R
----
T
-
M
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
-
E
-
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
-
T
H
R
R
I
V
N
---
V
D
L
-
K
F
P
----
P
----
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
K
G
------
V
M
E
H
------
P
-----------
W
V
K
A
N
S
-----
R
R
V
L
P
P
-------
26
Blastp_CBE
86.60
80%
-110
- C1 -
-
2VGO
6.6
-
AUKBA_XENLA
B:
[9-276]
-------------------------------------------------------------------------
R
K
F
T
I
---
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
N
K
F
-
I
M
A
L
K
V
L
F
K
S
Q
L
-
E
-
K
---
V
E
-
H
-
Q
L
R
R
E
I
E
I
Q
S
H
L
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
G
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
-
V
I
H
R
D
I
K
P
E
N
L
L
---
M
G
Y
---
K
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
L
R
--
R
-
R
----
T
-
M
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
-
E
-
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
-
T
H
R
R
I
V
N
---
V
D
L
-
K
F
P
----
P
----
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
K
G
------
V
M
E
H
------
P
-----------
W
V
K
A
N
S
-----
R
R
V
L
P
P
-------
24
Blastp_CBE
86.26
80%
-115
- C1 -
-
3ZTX
7.9
-
AUKBA_XENLA
B:
[9-276]
-------------------------------------------------------------------------
R
K
F
T
I
---
D
D
F
D
I
G
R
P
L
-----
G
N
V
Y
L
A
R
E
---
K
---
Q
-
N
K
F
-
I
M
A
L
K
V
L
F
K
S
Q
L
-
E
-
K
-
E
G
V
E
-
H
-
Q
L
R
R
E
I
E
I
Q
S
H
L
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
G
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
-
V
I
H
R
D
I
K
P
E
N
L
L
---
M
G
Y
---
K
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
L
R
--
R
-
R
----
T
-
M
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
-
E
-
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
-
T
H
R
R
I
V
N
---
V
D
L
-
K
F
P
----
P
----
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
K
G
------
V
M
E
H
------
P
-----------
W
V
K
A
N
S
-----
R
R
V
L
P
P
-------
189
Blastp_CBE
86.14
71%
-109
- C1 -
-
5LXM
5.9
-
AURKA_HUMAN
A:
[6-272]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
T
----
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
---
P
S
N
-----
169
Blastp_CBE
85.94
73%
-114
- C1 -
-
5DNR
6.1
-
AURKA_HUMAN
A:
[7-270]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
T
----
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
178
Blastp_CBE
85.88
73%
-124
- C1 -
-
3E5A
7.9
-
AURKA_HUMAN
A:
[3-266]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
T
----
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
89
Blastp_CBE
85.75
71%
-117
- C1 -
-
2J4Z
7.1
-
AURKA_HUMAN
B:
[29-297]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
T
----
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
---
P
S
N
C
Q
---
170
Blastp_CBE
85.73
73%
-114
- C1 -
-
5DN3
6.5
-
AURKA_HUMAN
A:
[7-270]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
T
----
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
54
Blastp_CBE
85.54
71%
-123
- C1 -
-
5G15
6.6
-
AURKA_HUMAN
A:
[5-269]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
T
----
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
---
P
-------
82
Blastp_CBE
85.45
71%
-115
- C1 -
-
3UOD
7.2
-
AURKA_HUMAN
A:
[4-267]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
D
----
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
185
Blastp_CBE
85.42
70%
-113
- C1 -
-
5L8K
6.7
-
AURKA_HUMAN
A:
[8-274]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
T
----
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
---
P
S
N
-----
176
Blastp_CBE
85.16
72%
-119
- C1 -
-
5DT3
5.9
-
AURKA_HUMAN
A:
[4-266]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
T
----
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
199
Blastp_CBE
85.11
72%
-113
- C1 -
-
3HA6
8.6
-
AURKA_HUMAN
A:
[3-265]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
T
----
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
------------
217
Blastp_CBE
84.98
72%
-115
- C1 -
-
5ORO
6.3
-
AURKA_HUMAN
A:
[1-263]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
T
----
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
569
HHSearch
84.89
72%
-113
- C1 -
-
5L8L
6.2
-
AURKA_HUMAN
A:
[8-271]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
T
----
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
179
Blastp_CBE
84.79
70%
-112
- C1 -
-
6R4D
6.1
-
AURKA_HUMAN
A:
[9-273]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
T
----
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
---
P
S
------
215
Blastp_CBE
84.73
72%
-119
- C1 -
-
5ORR
6.7
-
AURKA_HUMAN
A:
[1-263]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
T
----
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
90
Blastp_CBE
84.61
71%
-120
- C1 -
-
2J4Z
7.1
-
AURKA_HUMAN
A:
[29-291]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
T
----
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
------------
209
Blastp_CBE
84.56
72%
-118
- C1 -
-
5ORY
6.3
-
AURKA_HUMAN
A:
[1-263]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
T
----
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
202
Blastp_CBE
84.54
72%
-114
- C1 -
-
5OSE
7.0
-
AURKA_HUMAN
A:
[1-263]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
T
----
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
112
Blastp_CBE
84.47
72%
-118
- C1 -
-
5DR2
4.6
-
AURKA_HUMAN
A:
[4-266]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
A
----
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
192
Blastp_CBE
84.42
71%
-117
- C1 -
-
1OL5
5.3
-
AURKA_HUMAN
A:
[5-266]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
T
----
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
------------------
197
Blastp_CBE
84.39
72%
-116
- C1 -
-
5OSD
6.2
-
AURKA_HUMAN
A:
[2-265]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
T
----
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
207
Blastp_CBE
84.36
72%
-114
- C1 -
-
5OS0
6.8
-
AURKA_HUMAN
A:
[1-263]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
T
----
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
187
Blastp_CBE
84.30
70%
-116
- C1 -
-
5G1X
6.5
-
AURKA_HUMAN
A:
[9-271]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
T
----
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
206
Blastp_CBE
84.27
72%
-115
- C1 -
-
5OS1
6.9
-
AURKA_HUMAN
A:
[1-263]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
T
----
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
195
Blastp_CBE
84.27
72%
-114
- C1 -
-
5OS5
6.8
-
AURKA_HUMAN
A:
[2-265]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
T
----
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
68
Blastp_CBE
84.22
71%
-106
- C1 -
-
4DEE
5.5
-
AURKA_HUMAN
A:
[4-272]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
D
----
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
---
P
S
N
C
Q
---
184
Blastp_CBE
84.21
70%
-113
- C1 -
-
5L8L
6.2
-
AURKA_HUMAN
A:
[8-271]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
T
----
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
125
Blastp_CBE
84.20
71%
-121
- C1 -
-
3W10
7.4
-
AURKA_HUMAN
A:
[1-263]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
A
----
A
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
------------
80
Blastp_CBE
84.20
71%
-115
- C1 -
-
3UOH
6.6
-
AURKA_HUMAN
B:
[4-267]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
D
----
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
129
Blastp_CBE
84.19
72%
-110
- C1 -
-
3H10
9.5
-
AURKA_HUMAN
A:
[3-266]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
A
----
A
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
85
Blastp_CBE
84.19
71%
-113
- C1 -
-
3UO5
6.4
-
AURKA_HUMAN
A:
[4-268]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
D
----
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
---
P
-------
95
Blastp_CBE
84.17
71%
-115
- C1 -
-
4JAJ
5.0
-
AURKA_HUMAN
A:
[14-277]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
T
----
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
205
Blastp_CBE
84.14
72%
-116
- C1 -
-
5OS3
6.5
-
AURKA_HUMAN
A:
[1-263]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
T
----
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
203
Blastp_CBE
84.14
72%
-114
- C1 -
-
5OS6
7.0
-
AURKA_HUMAN
A:
[1-263]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
T
----
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
194
Blastp_CBE
84.12
72%
-120
- C1 -
-
2W1C
6.9
-
AURKA_HUMAN
A:
[7-269]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
T
----
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
213
Blastp_CBE
84.09
72%
-110
- C1 -
-
5ORT
6.7
-
AURKA_HUMAN
A:
[1-263]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
T
----
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
214
Blastp_CBE
84.07
72%
-117
- C1 -
-
5ORS
6.7
-
AURKA_HUMAN
A:
[1-263]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
T
----
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
87
Blastp_CBE
84.00
71%
-115
- C1 -
-
3UNZ
7.4
-
AURKA_HUMAN
B:
[5-267]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
D
----
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
73
Blastp_CBE
83.98
71%
-114
- C1 -
-
3UP2
7.4
-
AURKA_HUMAN
A:
[4-267]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
D
----
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
114
Blastp_CBE
83.95
72%
-119
- C1 -
-
5DOS
5.0
-
AURKA_HUMAN
A:
[4-266]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
-----------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
143
Blastp_CBE
83.93
71%
-121
- C1 -
-
3FDN
5.9
-
AURKA_HUMAN
A:
[4-272]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
------------------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
---
P
S
N
C
Q
---
218
Blastp_CBE
83.85
72%
-111
- C1 -
-
5ORN
6.4
-
AURKA_HUMAN
A:
[1-263]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
T
----
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
212
Blastp_CBE
83.85
72%
-114
- C1 -
-
5ORV
6.6
-
AURKA_HUMAN
A:
[1-263]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
T
----
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
61
Blastp_CBE
83.82
71%
-122
- C1 -
-
5ZAN
7.3
-
AURKA_HUMAN
A:
[5-267]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
-----------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
211
Blastp_CBE
83.81
72%
-115
- C1 -
-
5ORW
6.4
-
AURKA_HUMAN
A:
[1-263]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
T
----
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
188
Blastp_CBE
83.75
70%
-108
- C1 -
-
4CEG
7.1
-
AURKA_HUMAN
A:
[9-273]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
T
----
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
---
P
S
------
92
Blastp_CBE
83.75
73%
-127
- C1 -
-
5OBJ
4.8
-
AURKA_HUMAN
A:
[8-270]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
----------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
86
Blastp_CBE
83.75
71%
-111
- C1 -
-
3UO4
7.3
-
AURKA_HUMAN
A:
[4-267]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
D
----
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
81
Blastp_CBE
83.74
71%
-113
- C1 -
-
3UOH
6.7
-
AURKA_HUMAN
A:
[4-267]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
D
----
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
191
Blastp_CBE
83.68
71%
-115
- C1 -
-
1OL7
5.9
-
AURKA_HUMAN
A:
[6-268]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
T
----
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
210
Blastp_CBE
83.64
72%
-115
- C1 -
-
5ORX
6.6
-
AURKA_HUMAN
A:
[1-263]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
T
----
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
58
Blastp_CBE
83.63
71%
-131
- C1 -
-
4C3P
5.5
-
AURKA_HUMAN
A:
[5-267]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
T
----
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
------------
565
HHSearch
83.60
73%
-116
- C1 -
-
5ORX
6.6
-
AURKA_HUMAN
A:
[3-261]
----------------------------------------------------------------------------
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
T
----
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
------------------
128
Blastp_CBE
83.59
72%
-112
- C1 -
-
3H10
9.2
-
AURKA_HUMAN
B:
[3-266]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
A
----
A
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
75
Blastp_CBE
83.59
71%
-115
- C1 -
-
3UOL
6.9
-
AURKA_HUMAN
A:
[5-267]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
D
----
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
74
Blastp_CBE
83.57
71%
-114
- C1 -
-
3UOL
6.8
-
AURKA_HUMAN
B:
[5-267]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
D
----
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
208
Blastp_CBE
83.56
72%
-117
- C1 -
-
5ORZ
6.4
-
AURKA_HUMAN
A:
[1-263]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
T
----
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
31
Blastp_CBE
83.54
73%
-125
- C1 -
-
3DJ7
9.2
-
AURKA_MOUSE
A:
[7-269]
-------------------------------------------------------------------------
R
Q
W
T
L
---
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
R
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
T
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
N
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--------------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
H
T
Y
Q
E
-
T
Y
R
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-----
T
L
A
E
------
V
L
E
H
------
P
-----------
W
I
K
A
N
S
-----
S
------------
84
Blastp_CBE
83.51
71%
-110
- C1 -
-
3UO6
5.7
-
AURKA_HUMAN
A:
[4-267]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
D
----
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
196
Blastp_CBE
83.50
69%
-111
- C1 -
-
4BN1
7.2
-
AURKA_HUMAN
A:
[8-270]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
M
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
T
----
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
------------
138
Blastp_CBE
83.45
71%
-127
- C1 -
-
4JBQ
6.8
-
AURKA_HUMAN
A:
[4-269]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
---------------------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
---
P
S
------
55
Blastp_CBE
83.44
71%
-113
- C1 -
-
4O0S
4.4
-
AURKA_HUMAN
A:
[5-270]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
------
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
---
P
S
------
133
Blastp_CBE
83.43
72%
-131
- C1 -
-
3H0Y
5.1
-
AURKA_HUMAN
A:
[3-265]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
--------------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
------------
103
Blastp_CBE
83.41
73%
-119
- C1 -
-
1MQ4
5.1
-
AURKA_HUMAN
A:
[7-269]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
---------
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
------------
165
Blastp_CBE
83.35
71%
-131
- C1 -
-
5ODT
5.5
-
AURKA_HUMAN
A:
[6-272]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
N
F
G
----
W
---
S
-
V
H
---------------------------
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
---
P
S
N
-----
216
Blastp_CBE
83.32
72%
-112
- C1 -
-
5ORP
6.0
-
AURKA_HUMAN
A:
[1-263]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
T
----
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
140
Blastp_CBE
83.28
71%
-111
- C1 -
-
4JBO
10.0
-
AURKA_HUMAN
A:
[4-269]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
T
----
D
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
---
P
S
------
107
Blastp_CBE
83.25
72%
-116
- C1 -
-
5DT4
5.8
-
AURKA_HUMAN
A:
[4-266]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
-----------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
88
Blastp_CBE
83.25
71%
-115
- C1 -
-
3UNZ
7.2
-
AURKA_HUMAN
A:
[5-267]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
D
----
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
18
PsiBlast_PDB
83.23
73%
-125
- C1 -
-
3D14
9.2
-
AURKA_MOUSE
A:
[7-269]
-------------------------------------------------------------------------
R
Q
W
T
L
---
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
R
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
T
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
N
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--------------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
H
T
Y
Q
E
-
T
Y
R
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-----
T
L
A
E
------
V
L
E
H
------
P
-----------
W
I
K
A
N
S
-----
S
------------
60
Blastp_CBE
83.16
71%
-122
- C1 -
-
2XNG
6.9
-
AURKA_HUMAN
A:
[7-269]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
--------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
180
Blastp_CBE
83.14
70%
-110
- C1 -
-
6R4C
6.6
-
AURKA_HUMAN
A:
[9-273]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
T
----
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
---
P
S
------
19
PsiBlast_PDB
83.12
73%
-145
- C1 -
-
3DJ5
10.0
-
AURKA_MOUSE
A:
[9-269]
---------------------------------------------------------------------------
W
T
L
---
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
R
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
T
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
N
---
G
E
---
L
K
I
A
D
F
G
----
W
----------------------
T
----
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
H
T
Y
Q
E
-
T
Y
R
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-----
T
L
A
E
------
V
L
E
H
------
P
-----------
W
I
K
A
N
S
-----
S
------------
77
Blastp_CBE
83.08
71%
-111
- C1 -
-
3UOK
6.0
-
AURKA_HUMAN
A:
[4-267]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
D
----
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
34
Blastp_CBE
83.08
73%
-129
- C1 -
-
3D15
8.8
-
AURKA_MOUSE
A:
[7-269]
-------------------------------------------------------------------------
R
Q
W
T
L
---
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
R
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
T
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
N
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
---------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
H
T
Y
Q
E
-
T
Y
R
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-----
T
L
A
E
------
V
L
E
H
------
P
-----------
W
I
K
A
N
S
-----
S
------------
190
Blastp_CBE
83.03
70%
-114
- C1 -
-
6I2U
7.7
-
AURKA_HUMAN
A:
[9-273]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
T
----
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
---
P
S
------
71
Blastp_CBE
83.01
71%
-111
- C1 -
-
4DEA
6.8
-
AURKA_HUMAN
A:
[4-267]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
D
----
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
182
Blastp_CBE
82.99
70%
-110
- C1 -
-
6R4A
7.3
-
AURKA_HUMAN
A:
[9-273]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
T
----
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
---
P
S
------
70
Blastp_CBE
83.00
71%
-111
- C1 -
-
4DEB
6.2
-
AURKA_HUMAN
A:
[4-266]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
D
----
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
------------
132
Blastp_CBE
82.99
72%
-132
- C1 -
-
3H0Z
7.4
-
AURKA_HUMAN
A:
[5-265]
---------------------------------------------------------------------------
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
--------------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
------------
162
Blastp_CBE
82.97
72%
-117
- C1 -
-
4DHF
6.5
-
AURKA_HUMAN
A:
[8-269]
---------------------------------------------------------------------------
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
----------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
17
PsiBlast_PDB
82.98
73%
-136
- C1 -
-
3DAJ
6.8
-
AURKA_MOUSE
A:
[8-269]
--------------------------------------------------------------------------
Q
W
T
L
---
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
R
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
T
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
N
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
--------------------------------
T
L
D
Y
L
P
P
E
M
I
----
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
H
T
Y
Q
E
-
T
Y
R
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-----
T
L
A
E
------
V
L
E
H
------
P
-----------
W
I
K
A
N
S
-----
S
------------
119
Blastp_CBE
82.97
71%
-115
- C1 -
-
3NRM
6.6
-
AURKA_HUMAN
A:
[6-268]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
A
----
A
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
------------
79
Blastp_CBE
82.96
71%
-112
- C1 -
-
3UOJ
5.5
-
AURKA_HUMAN
A:
[5-267]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
D
----
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
181
Blastp_CBE
82.94
70%
-110
- C1 -
-
6R4B
6.3
-
AURKA_HUMAN
A:
[9-273]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
T
----
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
---
P
S
------
83
Blastp_CBE
82.92
71%
-110
- C1 -
-
3UO6
6.4
-
AURKA_HUMAN
B:
[4-267]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
D
----
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
204
Blastp_CBE
82.91
72%
-114
- C1 -
-
5OS4
6.5
-
AURKA_HUMAN
A:
[1-263]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
T
----
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
142
Blastp_CBE
82.88
71%
-122
- C1 -
-
3K5U
6.7
-
AURKA_HUMAN
A:
[4-272]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
---------------------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
---
P
S
N
C
Q
---
121
Blastp_CBE
82.87
70%
-122
- C1 -
-
5AAF
8.6
-
AURKA_HUMAN
A:
[8-270]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
---------------------------
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
------------
110
Blastp_CBE
82.84
72%
-129
- C1 -
-
5DR9
6.0
-
AURKA_HUMAN
A:
[4-266]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
----------------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
91
Blastp_CBE
82.83
73%
-127
- C1 -
-
5OBR
6.5
-
AURKA_HUMAN
A:
[7-270]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
----------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
201
Blastp_CBE
82.82
72%
-111
- C1 -
-
5OSF
6.7
-
AURKA_HUMAN
A:
[1-263]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
T
----
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
118
Blastp_CBE
82.81
71%
-123
- C1 -
-
4O0W
3.4
-
AURKA_HUMAN
A:
[5-270]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
Y
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
----------------------
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
---
P
S
------
183
Blastp_CBE
82.79
70%
-116
- C1 -
-
6R49
5.1
-
AURKA_HUMAN
A:
[9-273]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
-----------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
---
P
S
------
127
Blastp_CBE
82.79
72%
-118
- C1 -
-
3H10
9.2
-
AURKA_HUMAN
D:
[3-265]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
----------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
------------
20
PsiBlast_PDB
82.77
73%
-140
- C1 -
-
3DJ6
10.9
-
AURKA_MOUSE
A:
[9-269]
---------------------------------------------------------------------------
W
T
L
---
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
R
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
T
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
N
---
G
E
---
L
K
I
A
D
F
G
----
W
----------------------
T
----
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
H
T
Y
Q
E
-
T
Y
R
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-----
T
L
A
E
------
V
L
E
H
------
P
-----------
W
I
K
A
N
S
-----
S
------------
65
Blastp_CBE
82.76
73%
-125
- C1 -
-
2W1F
4.9
-
AURKA_HUMAN
A:
[7-269]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
----------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
193
Blastp_CBE
82.74
72%
-126
- C1 -
-
2W1G
4.8
-
AURKA_HUMAN
A:
[7-269]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
76
Blastp_CBE
82.70
71%
-110
- C1 -
-
3UOK
5.8
-
AURKA_HUMAN
B:
[4-267]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
D
----
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
98
Blastp_CBE
82.68
73%
-133
- C1 -
-
6C2R
8.1
-
AURKA_HUMAN
A:
[9-270]
---------------------------------------------------------------------------
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
------------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
161
Blastp_CBE
82.64
72%
-122
- C1 -
-
4DHF
6.0
-
AURKA_HUMAN
B:
[8-269]
---------------------------------------------------------------------------
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
----------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
134
Blastp_CBE
82.64
71%
-125
- C1 -
-
4O0U
4.1
-
AURKA_HUMAN
A:
[5-270]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
R
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--------------------
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
---
P
S
------
78
Blastp_CBE
82.64
71%
-112
- C1 -
-
3UOJ
4.9
-
AURKA_HUMAN
B:
[5-267]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
D
----
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
159
Blastp_CBE
82.63
72%
-134
- C1 -
-
4PRJ
7.2
-
AURKA_HUMAN
A:
[4-266]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
---
G
N
V
Y
L
A
R
E
---
K
---
N
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
S
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
K
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
----------------------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
D
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
------------
200
Blastp_CBE
82.49
71%
-122
- C1 -
-
5EW9
8.3
-
AURKA_HUMAN
A:
[8-270]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
---------------
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
167
Blastp_CBE
82.48
69%
-119
- C1 -
-
6HJJ
8.4
-
AURKA_HUMAN
A:
[9-275]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
C
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
-----------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
---
P
S
N
A
----
69
Blastp_CBE
82.46
71%
-106
- C1 -
-
4DED
5.7
-
AURKA_HUMAN
A:
[4-266]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
D
----
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
------------
66
Blastp_CBE
82.45
73%
-125
- C1 -
-
2W1E
5.9
-
AURKA_HUMAN
A:
[7-269]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
-----------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
177
Blastp_CBE
82.43
72%
-117
- C1 -
-
5OS2
5.1
-
AURKA_HUMAN
A:
[1-263]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
----------------
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
219
Blastp_CBE
82.41
72%
-115
- C1 -
-
5ORL
6.9
-
AURKA_HUMAN
A:
[1-263]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
T
----
T
-
L
----
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
51
Blastp_CBE
82.39
71%
-118
- C1 -
-
4UZD
8.7
-
AURKA_HUMAN
B:
[2-266]
------------------------------------------------------------------------
K
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
-----------------
R
--
R
-
T
----
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
141
Blastp_CBE
82.34
71%
-118
- C1 -
-
3M11
9.6
-
AURKA_HUMAN
A:
[4-269]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
----------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
---
P
S
------
99
Blastp_CBE
82.34
73%
-124
- C1 -
-
3VAP
8.9
-
AURKA_HUMAN
A:
[8-269]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
-----------------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
------------
111
Blastp_CBE
82.30
72%
-127
- C1 -
-
5DR6
6.3
-
AURKA_HUMAN
A:
[4-266]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
----------------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
72
Blastp_CBE
82.26
71%
-113
- C1 -
-
3UP7
6.7
-
AURKA_HUMAN
A:
[4-265]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
D
----
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
------------------
16
PsiBlast_PDB
82.26
71%
-120
- C1 -
-
2WTW
8.1
-
AURKA_HUMAN
A:
[10-271]
---------------------------------------------------------------------------
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
R
G
E
V
Y
K
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--------------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
40
Blastp_CBE
82.24
70%
-122
- C1 -
-
4ZS0
6.0
-
AURKA_HUMAN
A:
[9-270]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
---------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
------------
198
Blastp_CBE
82.10
71%
-104
- C1 -
-
4J8M
10.0
-
AURKA_HUMAN
A:
[4-268]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-
D
----
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
---
P
S
N
-----
186
Blastp_CBE
82.07
70%
-121
- C1 -
-
5L8J
5.6
-
AURKA_HUMAN
A:
[8-273]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
--------------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
---
P
S
------
33
Blastp_CBE
82.07
73%
-131
- C1 -
-
3D2I
8.8
-
AURKA_MOUSE
A:
[8-269]
--------------------------------------------------------------------------
Q
W
T
L
---
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
R
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
T
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
N
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
----------------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
H
T
Y
Q
E
-
T
Y
R
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-----
T
L
A
E
------
V
L
E
H
------
P
-----------
W
I
K
A
N
S
-----
S
------------
97
Blastp_CBE
82.01
73%
-137
- C1 -
-
6C2T
7.3
-
AURKA_HUMAN
A:
[9-269]
---------------------------------------------------------------------------
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
---------------------
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
------------
36
Blastp_CBE
81.98
70%
-119
- C1 -
-
5ONE
8.4
-
AURKA_HUMAN
A:
[9-273]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
----------------------
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
---
P
S
------
52
Blastp_CBE
81.95
71%
-124
- C1 -
-
4UZD
7.8
-
AURKA_HUMAN
A:
[4-265]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----------------------
R
--
R
-
T
----
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
------------
122
Blastp_CBE
81.89
70%
-122
- C1 -
-
5AAE
8.0
-
AURKA_HUMAN
A:
[8-270]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
-----------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
------------
56
Blastp_CBE
81.88
71%
-125
- C1 -
-
4C3R
5.2
-
AURKA_HUMAN
A:
[6-267]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
----------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
------------
109
Blastp_CBE
81.86
72%
-120
- C1 -
-
5DRD
7.4
-
AURKA_HUMAN
A:
[4-266]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
-----------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
67
Blastp_CBE
81.84
73%
-128
- C1 -
-
2W1D
4.1
-
AURKA_HUMAN
A:
[7-269]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
-----------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
---
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
166
Blastp_CBE
81.79
69%
-117
- C1 -
-
6HJK
5.2
-
AURKA_HUMAN
A:
[9-273]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
C
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
----------------------------
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
---
P
S
------
139
Blastp_CBE
81.78
71%
-118
- C1 -
-
4JBP
10.5
-
AURKA_HUMAN
A:
[4-268]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
----------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
---
P
-------
45
Blastp_CBE
81.78
71%
-121
- C1 -
-
6CPG
4.7
-
AURKA_HUMAN
D:
[9-270]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-------------------------
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
------------
11
PsiBlast_PDB
81.76
77%
-120
- C1 -
-
4B8L
5.1
-
AUKBA_XENLA
A:
[11-275]
--------------------------------------------------------------------------
K
F
T
I
---
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
N
K
F
-
I
M
A
L
K
V
L
F
K
S
Q
L
-
E
-
K
-
E
G
V
E
-
H
-
Q
L
R
R
E
I
E
I
Q
S
H
L
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
G
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
-
V
I
H
R
D
I
K
P
E
N
L
L
---
M
G
Y
---
K
---
G
E
---
L
K
I
A
D
F
------------------------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
-
E
-
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
-
T
H
R
R
I
V
N
---
V
D
L
-
K
F
P
----
P
----
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
K
G
------
V
M
E
H
------
P
-----------
W
V
K
A
N
S
-----
R
R
V
L
---------
108
Blastp_CBE
81.72
72%
-117
- C1 -
-
5DT0
5.4
-
AURKA_HUMAN
A:
[4-266]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
-----------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
38
Blastp_CBE
81.70
70%
-127
- C1 -
-
4ZTR
9.4
-
AURKA_HUMAN
A:
[9-270]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
-----------------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
------------
163
Blastp_CBE
81.65
72%
-122
- C1 -
-
3R22
7.3
-
AURKA_HUMAN
A:
[6-269]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
137
Blastp_CBE
81.65
71%
-127
- C1 -
-
3LAU
6.2
-
AURKA_HUMAN
A:
[1-268]
-------------------------------------------------------------------
M
----
K
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
-------------------------------------------
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
---
P
S
------
39
Blastp_CBE
81.54
70%
-134
- C1 -
-
4ZTQ
7.3
-
AURKA_HUMAN
A:
[9-270]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
-----------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
-----
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
------------
123
Blastp_CBE
81.49
70%
-125
- C1 -
-
5AAD
7.5
-
AURKA_HUMAN
A:
[9-270]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
--------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
------------
64
Blastp_CBE
81.47
71%
-135
- C1 -
-
3W16
5.3
-
AURKA_HUMAN
A:
[1-263]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
-----------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
-----
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
------------
105
Blastp_CBE
81.41
73%
-123
- C1 -
-
3O50
8.7
-
AURKA_HUMAN
B:
[2-265]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
----------------------------
T
----
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
----
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
47
Blastp_CBE
81.39
71%
-114
- C1 -
-
6CPF
5.0
-
AURKA_HUMAN
A:
[10-274]
---------------------------------------------------------------------------
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
---
P
S
N
-----
113
Blastp_CBE
81.36
72%
-124
- C1 -
-
5DPV
5.9
-
AURKA_HUMAN
A:
[4-266]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--------------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
145
Blastp_CBE
81.30
71%
-127
- C1 -
-
2C6E
11.1
-
AURKA_HUMAN
A:
[9-271]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-------------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
126
Blastp_CBE
81.30
72%
-134
- C1 -
-
3P9J
6.2
-
AURKA_HUMAN
A:
[3-265]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
-----------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
-----
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
------------
42
Blastp_CBE
81.30
70%
-122
- C1 -
-
4BYI
6.5
-
AURKA_HUMAN
A:
[8-270]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
------------
135
Blastp_CBE
81.28
71%
-126
- C1 -
-
4UZH
5.6
-
AURKA_HUMAN
A:
[1-268]
-------------------------------------------------------------------
M
----
K
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
-------------------------------------------
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
---
P
S
------
120
Blastp_CBE
81.25
70%
-126
- C1 -
-
5AAG
8.9
-
AURKA_HUMAN
A:
[9-270]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
---------------------------
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
------------
164
Blastp_CBE
81.18
72%
-127
- C1 -
-
3R21
6.4
-
AURKA_HUMAN
A:
[7-269]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
-----------------------
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
160
Blastp_CBE
81.16
71%
-125
- C1 -
-
2XRU
6.8
-
AURKA_HUMAN
A:
[3-265]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
----------------------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
------------
101
Blastp_CBE
80.99
73%
-142
- C1 -
-
2X81
8.1
-
AURKA_HUMAN
A:
[8-269]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
---
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
-------------------------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
------------
37
Blastp_CBE
80.93
70%
-129
- C1 -
-
4ZTS
9.4
-
AURKA_HUMAN
A:
[9-270]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
--------------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
------------
35
Blastp_CBE
80.88
70%
-125
- C1 -
-
6GRA
10.2
-
AURKA_HUMAN
A:
[8-271]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
------------------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
32
Blastp_CBE
80.78
73%
-136
- C1 -
-
3D2K
8.3
-
AURKA_MOUSE
A:
[9-269]
---------------------------------------------------------------------------
W
T
L
---
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
R
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
T
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
N
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
-----------------------------
T
L
D
Y
L
P
P
E
M
I
-----
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
H
T
Y
Q
E
-
T
Y
R
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-----
T
L
A
E
------
V
L
E
H
------
P
-----------
W
I
K
A
N
S
-----
S
------------
106
Blastp_CBE
80.75
73%
-125
- C1 -
-
3O50
7.7
-
AURKA_HUMAN
A:
[2-264]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
------------------------------------
T
L
D
Y
L
P
P
E
M
I
E
---
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
------------
93
Blastp_CBE
80.63
71%
-123
- C1 -
-
2J50
6.5
-
AURKA_HUMAN
B:
[5-265]
---------------------------------------------------------------------------
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
---------------------
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
----
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
------------
53
Blastp_CBE
80.58
71%
-128
- C1 -
-
1MUO
3.7
-
AURKA_HUMAN
A:
[22-282]
---------------------------------------------------------------------------
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-------------------------
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
------------
100
Blastp_CBE
80.55
73%
-124
- C1 -
-
3MYG
7.2
-
AURKA_HUMAN
A:
[7-269]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
-----------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
------------
117
Blastp_CBE
80.51
71%
-141
- C1 -
-
3EFW
8.6
-
AURKA_HUMAN
A:
[126-388]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
-------------------------------------------
L
D
Y
L
P
P
E
M
I
-------
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
------------
44
Blastp_CBE
80.49
70%
-120
- C1 -
-
2X6D
9.0
-
AURKA_HUMAN
A:
[8-270]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
------
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
----------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
------------
46
Blastp_CBE
80.42
71%
-120
- C1 -
-
6CPG
5.2
-
AURKA_HUMAN
A:
[9-269]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
----------------------------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
------------------
94
Blastp_CBE
80.40
71%
-124
- C1 -
-
2J50
6.5
-
AURKA_HUMAN
A:
[5-265]
---------------------------------------------------------------------------
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
---------------------
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
----
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
------------
175
Blastp_CBE
80.37
72%
-122
- C1 -
-
3QBN
5.1
-
AURKA_HUMAN
A:
[4-266]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
----------------------------------
T
-
L
----
S
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
------------
57
Blastp_CBE
80.36
71%
-134
- C1 -
-
4C3P
4.7
-
AURKA_HUMAN
D:
[5-269]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-----------------
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
---
P
-------
130
Blastp_CBE
80.33
72%
-130
- C1 -
-
3H0Z
8.5
-
AURKA_HUMAN
C:
[3-265]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
-------------------------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
------------
144
Blastp_CBE
80.26
71%
-121
- C1 -
-
2C6E
9.5
-
AURKA_HUMAN
B:
[9-270]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
------------------------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
------------
50
Blastp_CBE
80.14
71%
-127
- C1 -
-
6C83
5.3
-
AURKA_HUMAN
A:
[9-271]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
-----------------------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
168
Blastp_CBE
79.94
73%
-133
- C1 -
-
2WQE
5.0
-
AURKA_HUMAN
A:
[1-261]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
R
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
------------------------------------------
G
T
L
D
Y
L
P
P
E
M
I
-----
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
------------------
136
Blastp_CBE
79.73
71%
-122
- C1 -
-
4UYN
8.5
-
AURKA_HUMAN
A:
[2-268]
------------------------------------------------------------------------
K
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
---
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
------------------------------------------
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
---
P
S
------
104
Blastp_CBE
79.69
73%
-141
- C1 -
-
3O51
7.0
-
AURKA_HUMAN
A:
[2-264]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
-------------------------------------------
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
------------
49
Blastp_CBE
79.58
71%
-123
- C1 -
-
6C83
4.1
-
AURKA_HUMAN
B:
[9-270]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
-----------------------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
------------
115
Blastp_CBE
79.54
71%
-127
- C1 -
-
1OL6
4.8
-
AURKA_HUMAN
A:
[7-266]
---------------------------------------------------------------------------
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
-
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
--
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
N
F
G
----
W
---
S
-
V
H
-----------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
-
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
------------------
124
Blastp_CBE
79.49
72%
-124
- C1 -
-
2XNE
6.6
-
AURKA_HUMAN
A:
[7-268]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
----------
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
N
F
G
----
W
---
S
-
V
H
--
A
-
P
------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
------------
148
Blastp_CBE
79.43
71%
-119
- C1 -
-
2C6D
5.5
-
AURKA_HUMAN
A:
[3-266]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
----------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
116
Blastp_CBE
79.43
71%
-132
- C1 -
-
3EFW
9.5
-
AURKA_HUMAN
B:
[126-389]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
-------------------------------------------
L
D
Y
L
P
P
E
M
I
E
------
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
-----------
41
Blastp_CBE
79.35
70%
-122
- C1 -
-
4BYJ
6.3
-
AURKA_HUMAN
A:
[8-270]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
-------------------------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
------------
96
Blastp_CBE
79.34
71%
-121
- C1 -
-
4JAI
8.5
-
AURKA_HUMAN
A:
[14-278]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
------------------------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
---
P
-------
147
Blastp_CBE
79.29
72%
-121
- C1 -
-
3COH
7.3
-
AURKA_HUMAN
A:
[5-265]
---------------------------------------------------------------------------
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
N
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
S
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
K
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
------------------------------------
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
D
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
------------
146
Blastp_CBE
79.15
72%
-122
- C1 -
-
3COH
7.3
-
AURKA_HUMAN
B:
[5-265]
---------------------------------------------------------------------------
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
N
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
S
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
K
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
------------------------------------
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
D
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
------------
220
Blastp_CBE
79.13
71%
-99
- C1 -
-
2DWB
5.7
-
AURKA_HUMAN
A:
[8-271]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
---------
T
-
L
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
------
P
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
---
P
-------
43
Blastp_CBE
78.16
70%
-122
- C1 -
-
2X6E
7.9
-
AURKA_HUMAN
A:
[8-270]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
-----------------------------
T
L
D
Y
L
P
P
E
M
I
E
---
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
------------
59
Blastp_CBE
77.27
71%
-117
- C1 -
-
4B0G
7.9
-
AURKA_HUMAN
A:
[6-271]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-------
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
------------------------------
T
L
D
Y
L
P
P
E
M
I
E
---
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
---
P
S
------
131
Blastp_CBE
77.26
72%
-127
- C1 -
-
3H0Z
7.4
-
AURKA_HUMAN
B:
[3-265]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
------
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
-------------------------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
------------
62
Blastp_CBE
76.37
71%
-134
- C1 -
-
3W18
8.9
-
AURKA_HUMAN
B:
[1-263]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
----------------
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
-----------------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
-----
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
------------
63
Blastp_CBE
73.54
71%
-135
- C1 -
-
3W18
7.9
-
AURKA_HUMAN
A:
[1-263]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
--
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
---------
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
-------------------------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
-----
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
------------
172
Blastp_CBE
73.21
70%
-58
- C1 -
-
2WTV
9.2
-
AURKA_HUMAN
C:
[8-271]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
R
G
E
V
Y
K
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-------------
L
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
---
P
S
N
-----
173
Blastp_CBE
73.09
70%
-60
- C1 -
-
2WTV
9.4
-
AURKA_HUMAN
B:
[8-271]
-------------------------------------------------------------------------
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
R
G
E
V
Y
K
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-------------
L
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
---
P
S
N
-----
171
Blastp_CBE
71.60
70%
-53
- C1 -
-
2WTV
8.9
-
AURKA_HUMAN
D:
[7-271]
------------------------------------------------------------------------
K
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
R
G
E
V
Y
K
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-------------
L
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
---
P
S
N
-----
174
Blastp_CBE
71.19
70%
-56
- C1 -
-
2WTV
8.8
-
AURKA_HUMAN
A:
[7-271]
------------------------------------------------------------------------
K
R
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
R
G
E
V
Y
K
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
--
R
-------------
L
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
-
T
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
------
V
L
E
H
------
P
-----------
W
I
T
A
N
S
-----
S
K
---
P
S
N
-----
301
Blastp_CBE
68.06
36%
-92
- C1 -
-
3IOP
7.9
-
PDPK1_HUMAN
A:
[33-297]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
-----------------
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
-
I
F
Q
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
304
Blastp_CBE
67.82
36%
-93
- C1 -
-
5LVP
5.0
-
PDPK1_HUMAN
C:
[32-296]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
-----------------
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
G
L
-
I
F
A
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
268
Blastp_CBE
67.59
36%
-88
- C1 -
-
2PE0
5.2
-
PDPK1_HUMAN
A:
[7-271]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
-------------------
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
-
I
F
Q
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
293
Blastp_CBE
67.58
36%
-91
- C1 -
-
3H9O
6.9
-
PDPK1_HUMAN
A:
[32-296]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
-----------------
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
-
I
F
Q
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
302
Blastp_CBE
67.28
36%
-87
- C1 -
-
3RWP
7.6
-
PDPK1_HUMAN
A:
[32-296]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
-----------------
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
-
I
F
Q
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
299
Blastp_CBE
67.25
36%
-87
- C1 -
-
3QCS
5.9
-
PDPK1_HUMAN
A:
[33-297]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
-----------------
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
-
I
F
Q
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
321
Blastp_CBE
67.18
35%
-77
- C1 -
-
2BIY
5.1
-
PDPK1_HUMAN
A:
[30-294]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
TAKV
L
---
S
-
P
E
--
S
-
K
-
Q
--
A
R
--
A
-
N
----
A
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
-
I
F
Q
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
284
Blastp_CBE
67.02
36%
-91
- C1 -
-
1OKZ
8.1
-
PDPK1_HUMAN
A:
[30-294]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
-----------------
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
-
I
F
Q
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
283
Blastp_CBE
67.02
36%
-88
- C1 -
-
1UU3
6.9
-
PDPK1_HUMAN
A:
[30-294]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
-------------------
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
-
I
F
Q
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
303
Blastp_CBE
66.97
36%
-135
- C1 -
-
5LVP
4.5
-
PDPK1_HUMAN
D:
[32-296]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
-------------------
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
G
L
-
I
F
A
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
323
Blastp_CBE
66.86
36%
-88
- C1 -
-
3NAY
9.0
-
PDPK1_HUMAN
A:
[29-293]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
------------
A
----
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
-
I
F
Q
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
267
Blastp_CBE
66.82
36%
-86
- C1 -
-
2PE1
5.8
-
PDPK1_HUMAN
A:
[7-271]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
-------------------
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
-
I
F
Q
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
280
Blastp_CBE
66.81
36%
-85
- C1 -
-
2XCH
7.7
-
PDPK1_HUMAN
A:
[30-294]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
------------
A
----
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
-
I
F
Q
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
297
Blastp_CBE
66.66
36%
-84
- C1 -
-
3QCY
7.1
-
PDPK1_HUMAN
A:
[33-297]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
------------------------
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
-
I
F
Q
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
152
Blastp_CBE
66.63
73%
-154
- C1 -
-
3W2C
8.5
-
AURKA_HUMAN
A:
[1-260]
---------------------------------------------------------------------------
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
-----------------
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
-----------
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
-------------------------------------------
T
L
D
Y
L
P
P
E
M
I
E
---------
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
---
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
----------------------
H
------
P
-----------
W
I
T
A
N
S
------------------
285
Blastp_CBE
66.62
36%
-89
- C1 -
-
1OKY
8.7
-
PDPK1_HUMAN
A:
[30-294]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
-
P
-
E
--
S
----------
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
-
I
F
Q
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
298
Blastp_CBE
66.56
36%
-88
- C1 -
-
3QCX
7.0
-
PDPK1_HUMAN
A:
[33-297]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
-----------------
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
-
I
F
Q
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
290
Blastp_CBE
66.54
36%
-85
- C1 -
-
3NUN
5.4
-
PDPK1_HUMAN
A:
[14-278]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
-----------------
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
-
I
F
Q
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
286
Blastp_CBE
66.50
35%
-88
- C1 -
-
3ION
8.2
-
PDPK1_HUMAN
A:
[33-297]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
TAKV
L
---
S
------------------------------
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
-
I
F
Q
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
150
Blastp_CBE
66.46
73%
-157
- C1 -
-
3W2C
8.2
-
AURKA_HUMAN
E:
[1-260]
---------------------------------------------------------------------------
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
-----------------
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
------------
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
-------------------------------------------
T
L
D
Y
L
P
P
E
M
I
E
---------
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
---
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
----------------------
H
------
P
-----------
W
I
T
A
N
S
------------------
281
Blastp_CBE
66.41
36%
-89
- C1 -
-
1UU8
3.1
-
PDPK1_HUMAN
A:
[30-294]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
------------
A
----
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
-
I
F
Q
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
322
Blastp_CBE
66.39
36%
-92
- C1 -
-
3NAY
8.8
-
PDPK1_HUMAN
B:
[29-293]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
------------
A
----
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
-
I
F
Q
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
273
Blastp_CBE
66.41
36%
-85
- C1 -
-
3NUU
3.5
-
PDPK1_HUMAN
A:
[8-272]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
-----------------
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
-
I
F
Q
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
266
Blastp_CBE
66.40
36%
-88
- C1 -
-
2PE2
3.0
-
PDPK1_HUMAN
A:
[7-271]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
-------------------
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
-
I
F
Q
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
288
Blastp_CBE
66.39
36%
-88
- C1 -
-
3SC1
4.5
-
PDPK1_HUMAN
A:
[32-296]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
------------
A
----
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
-
I
F
Q
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
348
Blastp_CBE
66.37
36%
-84
- C1 -
-
2XCK
8.3
-
PDPK1_HUMAN
A:
[30-294]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
T
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
------------
A
----
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
-
I
F
Q
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
275
Blastp_CBE
66.36
36%
-85
- C1 -
-
1UU9
3.2
-
PDPK1_HUMAN
A:
[9-273]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
-----------------
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
-
I
F
Q
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
269
Blastp_CBE
66.31
36%
-89
- C1 -
-
1Z5M
7.2
-
PDPK1_HUMAN
A:
[7-271]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
-------------------
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
-
I
F
Q
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
276
Blastp_CBE
66.22
36%
-131
- C1 -
-
5HO8
6.0
-
PDPK1_HUMAN
A:
[30-294]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
-----------------
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
-
I
F
Q
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
296
Blastp_CBE
66.06
36%
-86
- C1 -
-
3QD0
8.0
-
PDPK1_HUMAN
A:
[33-297]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
-------------------------
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
-
I
F
Q
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
151
Blastp_CBE
65.99
73%
-158
- C1 -
-
3W2C
8.2
-
AURKA_HUMAN
C:
[1-260]
---------------------------------------------------------------------------
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
-----------------
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
------------
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
-------------------------------------------
T
L
D
Y
L
P
P
E
M
I
E
---------
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
---
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
----------------------
H
------
P
-----------
W
I
T
A
N
S
------------------
287
Blastp_CBE
65.98
35%
-93
- C1 -
-
2R7B
6.8
-
PDPK1_HUMAN
A:
[33-297]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
TAKV
L
-----------------------------
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
-
I
F
Q
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
300
Blastp_CBE
65.93
36%
-84
- C1 -
-
3QCQ
6.0
-
PDPK1_HUMAN
A:
[33-297]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
-----------------
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
-
I
F
Q
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
305
Blastp_CBE
65.86
36%
-126
- C1 -
-
5LVP
5.2
-
PDPK1_HUMAN
B:
[32-296]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
-----------------
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
G
L
-
I
F
A
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
306
Blastp_CBE
65.60
36%
-137
- C1 -
-
5LVP
5.3
-
PDPK1_HUMAN
A:
[32-296]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
-------------------
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
G
L
-
I
F
A
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
278
Blastp_CBE
65.36
36%
-133
- C1 -
-
5HNG
4.3
-
PDPK1_HUMAN
A:
[30-294]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
-
P
---------------
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
-
I
F
Q
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
229
Blastp_CBE
64.98
33%
-66
- C1 -
-
4CZU
4.1
-
CIPKN_ARATH
D:
[1-273]
----------------------------------------------------------------
P
G
I
H
----
S
G
R
T
R
V
---
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
---
V
---
E
-
N
G
D
-
N
V
A
I
K
V
I
D
K
E
K
V
-
L
-
K
-
N
K
M
I
-
A
-
Q
I
K
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
-
R
G
-
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
D
A
---
N
---
G
A
---
L
K
V
S
D
F
G
----
L
---
S
-
A
L
--
P
-
Q
-
Q
--
V
R
--
E
-
D
----
G
-
L
LHDT
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
G
A
-
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
S
-
L
Y
K
K
I
F
K
---
A
E
F
-
T
C
P
----
P
----
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
E
------
V
I
E
N
------
E
-----------
W
F
K
---------------------
149
Blastp_CBE
64.88
73%
-146
- C1 -
-
3W2C
8.3
-
AURKA_HUMAN
G:
[1-260]
---------------------------------------------------------------------------
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
-----------------
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
------------
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
-------------------------------------------
T
L
D
Y
L
P
P
E
M
I
E
---------
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
---
Y
K
R
I
S
R
---
V
E
F
-
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
----------------------
H
------
P
-----------
W
I
T
A
N
S
------------------
279
Blastp_CBE
64.78
36%
-135
- C1 -
-
5HKM
7.0
-
PDPK1_HUMAN
A:
[30-294]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
-------------------
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
-
I
F
Q
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
228
Blastp_CBE
64.45
34%
-60
- C1 -
-
4CZT
4.0
-
CIPKN_ARATH
A:
[2-271]
-----------------------------------------------------------------
G
I
H
----
S
G
R
T
R
V
---
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
---
V
---
E
-
N
G
D
-
N
V
A
I
K
V
I
D
K
E
K
V
-
L
-
K
-
N
K
M
I
-
A
-
Q
I
K
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
-
R
G
-
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
D
A
---
N
---
G
A
---
L
K
V
S
D
F
G
----
L
---
S
-
A
L
--
P
-
Q
-
Q
--
V
R
--
E
-
D
GLLH
T
-
T
----
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
G
A
-
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
S
-
L
Y
K
K
I
F
K
---
A
E
F
-
T
C
P
----
P
----
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
E
------
V
I
E
N
------
E
-----------
W
F
K
---------------------
225
Blastp_CBE
64.34
34%
-61
- C1 -
-
4CZT
3.7
-
CIPKN_ARATH
D:
[1-273]
----------------------------------------------------------------
P
G
I
H
----
S
G
R
T
R
V
---
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
---
V
---
E
-
N
G
D
-
N
V
A
I
K
V
I
D
K
E
K
V
-
L
-
K
-
N
K
M
I
-
A
-
Q
I
K
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
-
R
G
-
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
D
A
---
N
---
G
A
---
L
K
V
S
D
F
G
----
L
---
S
-
A
L
--
P
-
Q
-
Q
--
V
R
--
E
-
D
GLLH
T
-
T
----
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
G
A
-
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
S
-
L
Y
K
K
I
F
K
---
A
E
F
-
T
C
P
----
P
----
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
E
------
V
I
E
N
------
E
-----------
W
F
K
---------------------
291
Blastp_CBE
64.29
36%
-84
- C1 -
-
4XX9
6.0
-
PDPK1_HUMAN
A:
[31-295]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
-
P
-
E
--
S
K
QA
R
-
A
----
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
G
L
-
I
F
A
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
312
Blastp_CBE
64.23
36%
-85
- C1 -
-
4RRV
5.6
-
PDPK1_HUMAN
A:
[32-296]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
-
P
-
E
--
S
K
QA
R
-
A
----
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
G
L
-
I
F
A
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
355
Blastp_CBE
64.18
35%
-83
- C1 -
-
3PWY
2.9
-
PDPK1_HUMAN
A:
[32-296]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
C
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
TAKV
L
---
S
-
P
---------------------
S
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
S
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
-
I
F
Q
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
314
Blastp_CBE
64.10
36%
-83
- C1 -
-
4RQK
6.0
-
PDPK1_HUMAN
A:
[32-296]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
-
P
-
E
--
S
K
QA
R
-
A
----
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
G
L
-
I
F
A
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
559
HHSearch
64.09
33%
-41
- C1 -
-
4GV1
7.3
-
AKT1_HUMAN
A:
[6-278]
----------------------------------------------------------------------------
T
M
---
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
---
A
-
T
G
R
-
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
-
A
-
K
D
E
V
-
A
-
H
T
L
T
E
N
R
V
L
Q
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
-
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
-
V
V
Y
R
D
L
K
L
E
N
L
M
---
L
D
K
---
D
---
G
H
---
I
K
I
T
D
F
G
----
L
---
C
-
K
E
--
G
-
I
-
K
DG
A
T
--
M
-
K
----
T
-
F
----
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
G
-
R
-
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
K
-
L
F
E
L
I
L
M
---
E
E
I
-
R
F
P
----
R
----
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
GGGSE
D
A
K
E
------
I
M
Q
H
------
R
-----------
F
F
A
G
I
V
-----
W
------------
311
Blastp_CBE
64.06
36%
-82
- C1 -
-
5ACK
5.6
-
PDPK1_HUMAN
A:
[32-296]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
-
P
-
E
--
S
K
QA
R
-
A
----
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
G
L
-
I
F
A
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
230
Blastp_CBE
63.81
33%
-76
- C1 -
-
4CZU
5.3
-
CIPKN_ARATH
C:
[9-274]
----------------------------------------------------------------------------
R
V
---
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
---
V
---
E
-
N
G
D
-
N
V
A
I
K
V
I
D
K
E
K
V
-
L
-
K
-
N
K
M
I
-
A
-
Q
I
K
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
-
R
G
-
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
D
A
---
N
---
G
A
---
L
K
V
S
D
F
G
----
L
---
S
-
A
L
--
P
-
Q
-
Q
--
V
R
--
E
-
D
----
G
-
L
LHDT
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
G
A
-
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
S
-
L
Y
K
K
I
F
K
---
A
E
F
-
T
C
P
----
P
----
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
E
------
V
I
E
N
------
E
-----------
W
F
K
---------------------
308
Blastp_CBE
63.69
36%
-85
- C1 -
-
5LVN
4.7
-
PDPK1_HUMAN
A:
[32-296]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
-
P
-
E
--
S
K
QA
R
-
A
----
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
G
L
-
I
F
A
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
316
Blastp_CBE
63.68
36%
-84
- C1 -
-
4A06
4.5
-
PDPK1_HUMAN
A:
[32-296]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
-
P
-
E
--
S
K
QA
R
-
A
----
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
G
L
-
I
F
A
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
313
Blastp_CBE
63.65
36%
-81
- C1 -
-
4RQV
5.4
-
PDPK1_HUMAN
A:
[32-296]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
-
P
-
E
--
S
K
QA
R
-
A
----
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
G
L
-
I
F
A
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
307
Blastp_CBE
63.60
36%
-84
- C1 -
-
5LVO
6.4
-
PDPK1_HUMAN
A:
[32-296]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
-
P
-
E
--
S
K
QA
R
-
A
----
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
G
L
-
I
F
A
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
310
Blastp_CBE
63.53
36%
-84
- C1 -
-
5LVL
5.8
-
PDPK1_HUMAN
A:
[32-296]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
-
P
-
E
--
S
K
QA
R
-
A
----
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
G
L
-
I
F
A
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
232
Blastp_CBE
63.34
33%
-62
- C1 -
-
4CZU
3.7
-
CIPKN_ARATH
A:
[1-274]
----------------------------------------------------------------
P
G
I
H
----
S
G
R
T
R
V
---
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
---
V
---
E
-
N
G
D
-
N
V
A
I
K
V
I
D
K
E
K
V
-
L
-
K
-
N
K
M
I
-
A
-
Q
I
K
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
-
R
G
-
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
D
A
---
N
---
G
A
---
L
K
V
S
D
F
G
----
L
---
S
-
A
L
--
P
-
Q
-
Q
--
V
R
--
E
-
D
----
G
-
L
LHDT
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
G
A
-
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
S
-
L
Y
K
K
I
F
K
---
A
E
F
-
T
C
P
----
P
----
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
E
------
V
I
E
N
------
E
-----------
W
F
K
---------------------
483
Blastp_CBE
63.19
31%
-73
- C1 -
-
5FG8
5.2
-
KCC2A_DROME
A:
[14-277]
---------------------------------------------------------------------------------
D
N
Y
D
I
K
E
E
L
G
K
G
A
F
S
I
V
K
R
C
V
Q
---
K
---
S
-
T
G
F
-
E
F
A
A
K
I
I
N
T
K
K
L
-
T
-
A
-
R
D
F
Q
---
K
L
E
R
E
A
R
I
C
R
K
L
H
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
N
Y
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
F
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
-
N
G
-
V
V
H
R
D
L
K
P
E
N
L
L
---
L
A
S
---
K
---
A
K
GAA
V
K
L
A
D
F
G
----
L
---
A
-
I
E
--
V
-
Q
-
G
--
D
H
--
Q
-
A
WF--
G
-
F
----
A
G
T
P
G
Y
L
S
P
E
V
L
K
K
E
P
Y
G
-
K
-
S
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
-
L
Y
S
Q
I
K
A
---
G
A
Y
-
D
Y
P
----
S
PEWD
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
V
N
P
N
K
R
I
-----
T
A
A
E
------
A
L
K
H
------
P
-----------
W
I
C
Q
R
-------------------
438
Blastp_CBE
63.12
33%
-109
- C1 -
-
5KZ7
7.7
-
MARK2_HUMAN
A:
[32-286]
-----------------------------------------------------------------------------
I
---
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
---
I
---
L
-
T
G
K
-
E
V
A
V
K
I
I
D
K
T
Q
L
-
N
-
S
-
S
S
L
Q
---
K
L
F
R
E
V
R
I
M
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
F
-
I
V
H
R
D
L
K
A
E
N
L
L
---
L
D
A
---
D
---
M
N
---
I
K
I
A
D
F
-----------------------------------------
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
--
D
-
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
--
N
L
K
E
-
L
R
E
R
V
L
R
---
G
K
Y
-
R
I
P
----
F
----
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
------
I
M
K
D
------
R
-----------
W
M
----------------------
444
Blastp_CBE
63.07
34%
-48
- C1 -
-
5N23
6.4
-
KAPCA_HUMAN
A:
[41-304]
-----------------------------------------------------------------------------
L
---
D
Q
F
E
R
I
R
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
K
---
E
-
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
-
K
L
K
Q
I
E
-
H
-
T
L
N
-
E
K
R
I
Q
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
Q
---
Q
---
G
Y
---
I
K
V
A
D
F
G
----
F
---
A
-
K
R
--
V
-
K
-
G
---
R
--
T
-
P
----
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
-
I
Y
E
K
I
V
S
---
G
K
V
-
R
F
P
----
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
------
I
K
N
H
------
K
-----------
W
-----------------------
362
Blastp_CBE
62.98
36%
-71
- C1 -
-
4AW0
5.6
-
PDPK1_HUMAN
A:
[32-296]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
-
P
-
E
--
S
K
QA
R
-
A
----
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-
S
A
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
G
L
-
I
F
A
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
318
Blastp_CBE
62.97
36%
-82
- C1 -
-
3HRF
5.5
-
PDPK1_HUMAN
A:
[32-296]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
-
P
-
E
--
S
K
QA
R
-
A
----
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
G
L
-
I
F
A
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
403
Blastp_CBE
62.96
32%
-112
- C1 -
-
5ES1
8.8
-
MARK4_HUMAN
A:
[14-268]
-----------------------------------------------------------------------------
V
---
G
N
Y
R
L
L
R
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
---
I
---
L
-
T
G
R
-
E
V
A
I
K
I
I
D
K
T
Q
L
-
N
-
P
-
S
S
L
Q
---
K
L
F
R
E
V
R
I
M
K
G
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
A
G
E
V
F
D
Y
L
V
S
H
G
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
H
Y
C
H
Q
-
K
N
-
I
V
H
R
D
L
K
A
E
N
L
L
---
L
D
A
---
E
---
A
N
---
I
K
I
A
D
F
G
----
F
---
S
-
N
------------------------------
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-
G
P
E
V
D
I
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
H
N
L
K
E
-
L
R
E
R
V
L
R
---
G
K
Y
-
R
V
P
----
F
----
Y
M
S
T
D
C
E
S
I
L
R
R
F
L
V
L
N
P
A
K
R
C
-----
T
L
E
Q
------
I
M
K
D
------
K
-----------
W
I
----------------------
315
Blastp_CBE
62.93
36%
-90
- C1 -
-
4AW1
7.3
-
PDPK1_HUMAN
A:
[32-296]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
-
P
-
E
--
S
----------
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
G
L
-
I
F
A
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
309
Blastp_CBE
62.79
36%
-82
- C1 -
-
5LVM
3.7
-
PDPK1_HUMAN
A:
[32-296]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
-
P
-
E
--
S
K
QA
R
-
A
----
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
G
L
-
I
F
A
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
437
Blastp_CBE
62.68
33%
-106
- C1 -
-
5KZ7
7.2
-
MARK2_HUMAN
B:
[32-286]
-----------------------------------------------------------------------------
I
---
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
---
I
---
L
-
T
G
K
-
E
V
A
V
K
I
I
D
K
T
Q
L
-
N
-
S
-
S
S
L
Q
---
K
L
F
R
E
V
R
I
M
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
F
-
I
V
H
R
D
L
K
A
E
N
L
L
---
L
D
A
---
D
---
M
N
---
I
K
I
A
D
F
-----------------------------------------
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
--
D
-
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
--
N
L
K
E
-
L
R
E
R
V
L
R
---
G
K
Y
-
R
I
P
----
F
----
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
------
I
M
K
D
------
R
-----------
W
M
----------------------
428
Blastp_CBE
62.42
33%
-95
- C1 -
-
5EAK
8.1
-
MARK2_HUMAN
B:
[15-268]
---------------------------------------------------------------------------------
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
---
I
---
L
-
T
G
K
-
E
V
A
V
K
I
I
D
K
T
Q
L
-
N
-
S
-
S
S
L
Q
---
K
L
F
R
E
V
R
I
M
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
F
-
I
V
H
R
D
L
K
A
E
N
L
L
---
L
D
A
---
D
---
M
N
---
I
K
I
A
D
F
G
----------------------------------
F
----
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
K
E
-
L
R
E
R
V
L
R
---
G
K
Y
-
R
I
P
----
F
----
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
------
I
M
K
D
------
R
-----------
W
M
----------------------
399
Blastp_CBE
62.42
36%
-47
- C1 -
-
6FDY
6.5
-
ULK3_HUMAN
U:
[10-269]
-----------------------------------------------------------------------------
L
---
D
G
F
I
L
T
E
R
L
G
-----
T
V
Y
K
A
Y
A
---
K
---
K
D
T
R
E
-
V
V
A
I
K
C
V
A
K
K
S
L
-
N
-
K
-
A
S
V
E
-
N
-
L
L
T
-
E
I
E
I
L
K
G
I
R
H
P
H
I
V
Q
L
K
D
F
Q
W
D
S
D
N
I
Y
L
I
M
E
F
C
A
G
G
D
L
S
R
F
I
H
T
R
R
I
-
L
P
E
K
V
A
R
V
F
M
Q
Q
L
A
S
A
L
Q
F
L
H
E
-
R
N
-
I
S
H
L
D
L
K
P
Q
N
I
L
---
L
S
S
LE-
K
---
P
H
---
L
K
L
A
D
F
G
----
F
---
A
-
Q
H
M-
S
-
P
-
W
--
D
E
--
K
-
H
----
V
-
L
----
R
G
S
P
L
Y
M
A
P
E
M
V
C
Q
R
Q
Y
D
-
A
-
R
V
D
L
W
S
M
G
V
I
L
Y
E
A
L
F
G
Q
P
P
F
A
S
R
S
F
S
E
-
L
E
E
K
I
R
S
NRV
I
E
L
-
P
L
R
----
P
----
L
L
S
R
D
C
R
D
L
L
Q
R
L
L
E
R
D
P
S
R
R
I
-----
S
F
Q
D
------
F
F
A
H
------
P
-----------
W
V
----------------------
436
Blastp_CBE
62.30
33%
-103
- C1 -
-
5KZ8
7.5
-
MARK2_HUMAN
A:
[32-286]
-----------------------------------------------------------------------------
I
---
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
---
I
---
L
-
T
G
K
-
E
V
A
V
K
I
I
D
K
T
Q
L
-
N
-
S
-
S
S
L
Q
---
K
L
F
R
E
V
R
I
M
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
F
-
I
V
H
R
D
L
K
A
E
N
L
L
---
L
D
A
---
D
---
M
N
---
I
K
I
A
D
F
G
---------------------------------------
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
K
E
-
L
R
E
R
V
L
R
---
G
K
Y
-
R
I
P
----
F
----
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
------
I
M
K
D
------
R
-----------
W
M
----------------------
429
Blastp_CBE
62.30
33%
-92
- C1 -
-
5EAK
7.4
-
MARK2_HUMAN
A:
[14-268]
-----------------------------------------------------------------------------
I
---
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
---
I
---
L
-
T
G
K
-
E
V
A
V
K
I
I
D
K
T
Q
L
-
N
-
S
-
S
S
L
Q
---
K
L
F
R
E
V
R
I
M
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
F
-
I
V
H
R
D
L
K
A
E
N
L
L
---
L
D
A
---
D
---
M
N
---
I
K
I
A
D
F
G
----
F
---
S
-------------------------
F
----
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
K
E
-
L
R
E
R
V
L
R
---
G
K
Y
-
R
I
P
----
F
----
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
------
I
M
K
D
------
R
-----------
W
M
----------------------
317
Blastp_CBE
62.30
36%
-82
- C1 -
-
3RCJ
5.7
-
PDPK1_HUMAN
A:
[32-296]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
-
P
-
E
--
S
K
QA
R
-
A
----
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
G
L
-
I
F
A
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
534
Blastp_CBE
62.29
32%
-48
- C1 -
-
2OH0
6.9
-
KAPCA_BOVIN
E:
[41-297]
-----------------------------------------------------------------------------
L
---
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
---
E
-
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
-
K
L
K
Q
I
E
-
H
-
T
L
N
E
K
R
I
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
----
F
---
A
-
K
R
--
V
-
K
-
G
---
R
--
T
-
W
----
T
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
-
I
Y
E
K
I
V
S
---
G
K
V
-
R
F
P
----
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
------
I
K
N
H
------
K
-----------
W
-----------------------
537
Blastp_CBE
62.21
32%
-50
- C1 -
-
2F7E
6.9
-
KAPCA_BOVIN
E:
[41-297]
-----------------------------------------------------------------------------
L
---
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
---
E
-
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
-
K
L
K
Q
I
E
-
H
-
T
L
N
E
K
R
I
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
----
F
---
A
-
K
R
--
V
-
K
-
G
---
R
--
T
-
W
----
T
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
-
I
Y
E
K
I
V
S
---
G
K
V
-
R
F
P
----
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
------
I
K
N
H
------
K
-----------
W
-----------------------
319
Blastp_CBE
62.16
36%
-78
- C1 -
-
3HRC
5.6
-
PDPK1_HUMAN
A:
[32-296]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
-
P
------A-
R
-
A
----
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
G
L
-
I
F
A
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
533
Blastp_CBE
62.01
32%
-50
- C1 -
-
2OJF
6.3
-
KAPCA_BOVIN
E:
[41-297]
-----------------------------------------------------------------------------
L
---
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
---
E
-
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
-
K
L
K
Q
I
E
-
H
-
T
L
N
E
K
R
I
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
----
F
---
A
-
K
R
--
V
-
K
-
G
---
R
--
T
-
W
----
T
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
-
I
Y
E
K
I
V
S
---
G
K
V
-
R
F
P
----
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
------
I
K
N
H
------
K
-----------
W
-----------------------
482
Blastp_CBE
62.04
31%
-71
- C1 -
-
5H9B
5.8
-
KCC2A_DROME
A:
[14-277]
---------------------------------------------------------------------------------
D
N
Y
D
I
K
E
E
L
G
K
G
A
F
S
I
V
K
R
C
V
Q
---
K
---
S
-
T
G
F
-
E
F
A
A
K
I
I
N
T
K
K
L
-
T
-
A
-
R
D
F
Q
---
K
L
E
R
E
A
R
I
C
R
K
L
H
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
N
Y
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
F
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
-
N
G
-
V
V
H
R
D
L
K
P
E
N
L
L
---
L
A
S
---
K
---
A
K
GAA
V
K
L
A
D
F
G
----
L
---
A
-
I
E
--
V
-
Q
-
G
--
D
H
--
Q
-
A
WF--
G
-
F
----
A
G
T
P
G
Y
L
S
P
E
V
L
K
K
E
P
Y
G
-
K
-
S
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
-
L
Y
S
Q
I
K
A
---
G
A
Y
-
D
Y
P
----
S
PEWD
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
V
N
P
N
K
R
I
-----
T
A
A
E
------
A
L
K
H
------
P
-----------
W
I
C
Q
R
-------------------
264
Blastp_CBE
62.01
36%
-77
- C1 -
-
1UVR
3.0
-
PDPK1_HUMAN
A:
[10-274]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
-
P
------A-
R
-
A
----
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
-
I
F
Q
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
373
Blastp_CBE
62.00
35%
4
- C1 -
-
3WF8
6.3
-
KS6B1_HUMAN
A:
[21-298]
-----------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
---
N
-
T
G
K
-
I
F
A
M
K
V
L
K
K
A
M
I
-
V
-
R
-
N
A
K
D
-
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
I
-
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
---
L
N
H
---
Q
---
G
H
---
V
K
L
T
D
F
G
----
L
CKE
S
-
I
H
--
D
-
G
-
T
--
V
T
--
H
-
T
------
F
----
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
H
N
-
R
-
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
-
T
I
D
K
I
L
K
---
C
K
L
-
N
L
P
----
P
----
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
GAGPG
D
A
G
E
------
V
Q
A
H
------
P
FFRHIN-----
W
E
E
L
L
A
-----
R
K
V
E
P
P
-------
391
Blastp_CBE
61.85
34%
-39
- C1 -
-
6BDL
4.5
-
B:
[30-317]
--------------------------------------------------------------------------
N
L
K
L
---
S
D
F
N
I
I
D
T
L
G
V
G
G
F
G
R
V
E
L
V
Q
L
---
K
---
S
-
E
E
S
K
T
F
A
M
K
I
L
K
K
R
H
I
-
V
-
D
-
T
R
Q
Q
-
E
-
H
I
R
S
E
K
Q
I
M
Q
G
A
H
S
D
F
I
V
R
L
Y
R
T
F
K
D
S
K
Y
L
Y
M
L
M
E
A
C
L
G
G
E
L
W
T
I
L
R
D
R
G
S
-
F
E
D
S
T
T
R
F
Y
T
A
C
V
V
E
A
F
A
Y
L
H
S
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
L
I
---
L
D
H
---
R
---
G
Y
---
A
K
L
V
D
F
G
----
F
---
A
-
K
K
--
I
-
G
-
F
--
G
K
--
K
-
T
----
W
-
F
----
C
G
T
P
E
Y
V
A
P
E
I
I
L
N
K
G
H
D
-
I
-
S
A
D
Y
W
S
L
G
I
L
M
Y
E
L
L
T
G
S
P
P
F
S
G
P
D
P
M
K
-
T
Y
N
I
I
L
R
G--
I
D
M
I
E
F
P
----
K
----
K
I
A
K
N
A
A
N
L
I
K
K
L
C
R
D
N
P
S
E
R
L
GNLKN
G
V
K
D
------
I
Q
K
H
------
K
-----------
W
F
E
G
F
N
WEGLR
K
G
T
L
T
P
P
I
I
P
S
V
A
289
Blastp_CBE
61.83
36%
-75
- C1 -
-
3RWQ
6.9
-
PDPK1_HUMAN
A:
[32-296]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
-
P
------A-
R
-
A
----
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
-
I
F
Q
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
363
Blastp_CBE
61.81
36%
-71
- C1 -
-
4A07
5.6
-
PDPK1_HUMAN
A:
[32-296]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
-
P
-
E
--
S
K
QA
R
-
A
----
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-
S
A
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
G
L
-
I
F
A
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
493
Blastp_CBE
61.78
32%
-47
- C1 -
-
2UZV
6.5
-
KAPCA_BOVIN
A:
[26-282]
-----------------------------------------------------------------------------
L
---
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
---
E
-
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
-
K
L
K
Q
I
E
-
H
-
T
L
N
E
K
R
I
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
----
F
---
A
-
K
R
--
V
-
K
-
G
---
R
--
T
-
W
----
T
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
-
I
Y
E
K
I
V
S
---
G
K
V
-
R
F
P
----
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
------
I
K
N
H
------
K
-----------
W
-----------------------
368
Blastp_CBE
61.68
35%
1
- C1 -
-
4L3J
6.8
-
KS6B1_HUMAN
A:
[20-297]
-----------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
---
N
-
T
G
K
-
I
F
A
M
K
V
L
K
K
A
M
I
-
V
-
R
-
N
A
K
D
T
A
-
H
T
K
A
E
R
N
I
L
E
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
I
-
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
---
L
N
H
---
Q
---
G
H
---
V
K
L
T
D
F
G
----
L
CKE
S
-
I
H
--
D
-
G
-
T
--
V
T
--
H
------
T
-
F
----
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
H
N
-
R
-
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
-
T
I
D
K
I
L
K
---
C
K
L
-
N
L
P
----
P
----
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
GAGPG
D
A
G
E
------
V
Q
A
H
------
P
FFRHIN-----
W
E
E
L
L
A
-----
R
K
V
E
P
P
-------
265
Blastp_CBE
61.62
36%
-77
- C1 -
-
1H1W
4.6
-
PDPK1_HUMAN
A:
[10-274]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
-
K
-
E
N
K
V
-
P
-
Y
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
-
P
------A-
R
-
A
----
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
-
I
F
Q
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
535
Blastp_CBE
61.57
32%
-53
- C1 -
-
2F7Z
7.6
-
KAPCA_BOVIN
E:
[41-297]
-----------------------------------------------------------------------------
L
---
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
---
E
-
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
-
K
L
K
Q
I
E
-
H
-
T
L
N
E
K
R
I
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
----
F
---
A
-
K
R
--
V
-
K
-
G
---
R
--
T
-
W
----
T
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
-
I
Y
E
K
I
V
S
---
G
K
V
-
R
F
P
----
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
------
I
K
N
H
------
K
-----------
W
-----------------------
271
Blastp_CBE
61.46
36%
-81
- C1 -
-
4CT1
5.1
-
PDPK1_HUMAN
A:
[32-296]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
V
E
K
R
H
V
-
H
-
K
-
E
N
K
I
-
P
-
Y
V
Q
R
E
K
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
C
F
Q
D
D
E
K
L
Y
L
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
-
P
-
E
--
S
K
QA
R
-
A
----
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
G
L
-
I
F
A
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
539
Blastp_CBE
61.44
31%
-77
- C1 -
-
5HU3
5.2
-
KCC2A_DROME
A:
[14-274]
---------------------------------------------------------------------------------
D
N
Y
D
I
K
E
E
L
G
K
G
A
F
S
I
V
K
R
C
V
Q
---
K
---
S
-
T
G
F
-
E
F
A
A
K
I
I
N
T
K
K
L
-
T
-
A
-
R
D
F
Q
---
K
L
E
R
E
A
R
I
C
R
K
L
H
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
N
Y
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
F
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
-
N
G
-
V
V
H
R
N
L
K
P
E
N
L
L
---
L
A
S
---
K
---
A
K
GAA
V
K
L
A
D
F
G
----
L
---
A
-
I
E
--
V
-
Q
-
G
--
D
H
--
Q
-
A
WF--
G
-
F
----
A
G
T
P
G
Y
L
S
P
E
V
L
K
K
E
P
Y
G
-
K
-
S
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
-
L
Y
S
Q
I
K
A
---
G
A
Y
-
D
Y
P
----
S
PEWD
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
V
N
P
N
K
R
I
-----
T
A
A
E
------
A
L
K
H
------
P
-----------
W
I
----------------------
435
Blastp_CBE
61.40
33%
-102
- C1 -
-
5KZ8
7.2
-
MARK2_HUMAN
B:
[32-286]
-----------------------------------------------------------------------------
I
---
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
---
I
---
L
-
T
G
K
-
E
V
A
V
K
I
I
D
K
T
Q
L
-
N
-
S
-
S
S
L
Q
---
K
L
F
R
E
V
R
I
M
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
F
-
I
V
H
R
D
L
K
A
E
N
L
L
---
L
D
A
---
D
---
M
N
---
I
K
I
A
D
F
-----------------------------------------
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
K
E
-
L
R
E
R
V
L
R
---
G
K
Y
-
R
I
P
----
F
----
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
------
I
M
K
D
------
R
-----------
W
M
----------------------
367
Blastp_CBE
61.39
35%
-1
- C1 -
-
4L3L
6.9
-
KS6B1_HUMAN
A:
[20-297]
-----------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
---
N
-
T
G
K
-
I
F
A
M
K
V
L
K
K
A
M
I
-
V
-
R
-
N
A
K
D
T
A
-
H
T
K
A
E
R
N
I
L
E
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
I
-
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
---
L
N
H
---
Q
---
G
H
---
V
K
L
T
D
F
G
----
L
CKE
S
-
I
H
--
D
-
G
-
T
--
V
T
--
H
------
T
-
F
----
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
H
N
-
R
-
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
-
T
I
D
K
I
L
K
---
C
K
L
-
N
L
P
----
P
----
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
GAGPG
D
A
G
E
------
V
Q
A
H
------
P
FFRHIN-----
W
E
E
L
L
A
-----
R
K
V
E
P
P
-------
495
Blastp_CBE
61.36
32%
-53
- C1 -
-
2UZT
6.1
-
KAPCA_BOVIN
A:
[26-282]
-----------------------------------------------------------------------------
L
---
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
---
E
-
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
-
K
L
K
Q
I
E
-
H
-
T
L
N
E
K
R
I
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
----
F
---
A
-
K
R
--
V
-
K
-
G
---
R
--
T
-
W
----
T
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
-
I
Y
E
K
I
V
S
---
G
K
V
-
R
F
P
----
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
------
I
K
N
H
------
K
-----------
W
-----------------------
492
Blastp_CBE
61.35
32%
-50
- C1 -
-
2UZW
5.6
-
KAPCA_BOVIN
E:
[26-282]
-----------------------------------------------------------------------------
L
---
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
---
E
-
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
-
K
L
K
Q
I
E
-
H
-
T
L
N
E
K
R
I
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
----
F
---
A
-
K
R
--
V
-
K
-
G
---
R
--
T
-
W
----
T
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
-
I
Y
E
K
I
V
S
---
G
K
V
-
R
F
P
----
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
------
I
K
N
H
------
K
-----------
W
-----------------------
378
Blastp_CBE
61.19
35%
-78
- C1 -
-
3LIJ
3.9
-
?
A:
[43-302]
---------------------------------------------------------------------------------------
K
K
L
G
S
---
G
E
V
L
L
C
R
D
---
K
---
V
-
T
H
V
-
E
R
A
I
K
I
I
R
K
--------
S
S
-
N
-
S
-
K
L
L
E
E
V
A
V
L
K
L
L
D
H
P
N
I
M
K
L
Y
D
F
F
E
D
K
R
N
Y
Y
L
V
M
E
C
Y
K
G
G
E
L
F
D
E
I
I
H
R
M
K
-
F
N
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
K
-
H
N
-
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
---
K
---
E
K
DAL
I
K
I
V
D
F
G
----
L
---
S
A
V
F
--
E
-
N
-
Q
--
K
K
--
M
-
K
----
E
-
R
----
L
G
T
A
Y
Y
I
A
P
E
V
L
R
-
K
K
Y
D
-
E
-
K
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
G
G
Q
T
D
Q
E
-
I
L
R
K
V
E
K
---
G
K
Y
-
T
F
D
----
S
PEWK
N
V
S
E
G
A
K
D
L
I
K
Q
M
L
Q
F
D
S
Q
R
R
I
-----
S
A
Q
Q
------
A
L
E
H
------
P
-----------
W
I
K
---------------------
386
Blastp_CBE
61.05
34%
-31
- C1 -
-
6C0T
2.7
-
A:
[30-317]
--------------------------------------------------------------------------
N
L
K
L
---
S
D
F
N
I
I
D
T
L
G
V
G
G
F
G
R
V
E
L
V
Q
L
---
K
---
S
-
E
E
S
K
T
F
A
M
K
I
L
K
K
R
H
I
-
V
-
D
-
T
R
Q
Q
-
E
-
H
I
R
S
E
K
Q
I
M
Q
G
A
H
S
D
F
I
V
R
L
Y
R
T
F
K
D
S
K
Y
L
Y
M
L
M
E
A
C
L
G
G
E
L
W
T
I
L
R
D
R
G
S
-
F
E
D
S
T
T
R
F
Y
T
A
C
V
V
E
A
F
A
Y
L
H
S
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
L
I
---
L
D
H
---
R
---
G
Y
---
A
K
L
V
D
F
G
----
F
---
A
-
K
K
--
I
-
G
-
F
--
G
K
--
K
-
T
----
W
-
F
----
C
G
T
P
E
Y
V
A
P
E
I
I
L
N
K
G
H
D
-
I
-
S
A
D
Y
W
S
L
G
I
L
M
Y
E
L
L
T
G
S
P
P
F
S
G
P
D
P
M
K
-
T
Y
N
I
I
L
R
G--
I
D
M
I
E
F
P
----
K
----
K
I
A
K
N
A
A
N
L
I
K
K
L
C
R
D
N
P
S
E
R
L
GNLKN
G
V
K
D
------
I
Q
K
H
------
K
-----------
W
F
E
G
F
N
WEGLR
K
G
T
L
T
P
P
I
I
P
S
V
A
372
Blastp_CBE
61.05
35%
6
- C1 -
-
3WF9
6.3
-
KS6B1_HUMAN
A:
[21-298]
-----------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
---
N
-
T
G
K
-
I
F
A
M
K
V
L
K
K
A
M
I
-
V
-
R
-
N
A
K
D
-
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
I
-
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
---
L
N
H
---
Q
---
G
H
---
V
K
L
T
D
F
G
----
L
CKE
S
-
I
H
--
D
-
G
-
T
--
V
T
--
H
-
T
------
F
----
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
H
N
-
R
-
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
-
T
I
D
K
I
L
K
---
C
K
L
-
N
L
P
----
P
----
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
GAGPG
D
A
G
E
------
V
Q
A
H
------
P
FFRHIN-----
W
E
E
L
L
A
-----
R
K
V
E
P
P
-------
441
Blastp_CBE
60.88
34%
-74
- C1 -
-
3HZT
5.3
-
?
A:
[4-295]
---------------------------------------------------------------------------------
D
R
Y
Q
R
V
K
K
L
G
S
G
A
Y
G
E
V
L
L
C
K
D
---
K
---
L
-
T
G
A
-
E
R
A
I
K
I
I
K
K
S
S
V
-
T
-
T
-
T
S
N
S
-
G
-
A
L
L
D
E
V
A
V
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
R
N
Y
Y
L
V
M
E
V
Y
R
G
G
E
L
F
D
E
I
I
L
R
Q
K
-
F
S
E
V
D
A
A
V
I
M
K
Q
V
L
S
G
T
T
Y
L
H
K
-
H
N
-
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
---
K
---
S
R
DAL
I
K
I
V
D
F
G
----
L
---
S
-
A
H
--
F
-
E
V----------------------
G
T
A
Y
Y
I
A
P
E
V
L
R
-
K
K
Y
D
-
E
-
K
C
D
V
W
S
C
G
V
I
L
Y
I
L
L
C
G
Y
P
P
F
G
G
Q
T
D
Q
E
-
I
L
K
R
V
E
K
---
G
K
F
-
S
F
D
PPDW
T
----
Q
V
S
D
E
A
K
Q
L
V
K
L
M
L
T
Y
E
P
S
K
R
I
-----
S
A
E
E
------
A
L
N
H
------
P
-----------
W
I
----------------------
383
Blastp_CBE
60.38
34%
-61
- C1 -
-
3TXO
5.3
-
A:
[23-300]
---------------------------------------------------------------------------------
D
N
F
E
F
I
R
V
L
G
K
G
S
F
G
K
V
M
L
A
R
V
---
K
---
E
-
T
G
D
-
L
Y
A
V
K
V
L
K
K
D
V
I
L
Q
-
D
-
D
D
V
E
-
C
-
T
M
T
E
K
R
I
L
S
L
A
R
N
H
P
F
L
T
Q
L
F
C
C
F
Q
T
P
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
S
R
R
-
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
-
K
G
-
I
I
Y
R
D
L
K
L
D
N
V
L
---
L
D
H
---
E
---
G
H
---
C
K
L
A
D
F
G
----
M
---
C
-
K
E
--
G
I-----------------------
C
G
T
P
D
Y
I
A
P
E
I
L
Q
E
M
L
Y
G
-
P
-
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
A
P
F
E
A
E
N
E
D
D
-
L
F
E
A
I
L
N
---
D
E
V
-
V
Y
P
----
T
----
W
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
R
L
G----
S
L
T
Q
------
G
G
E
H
------
A
ILRHPFFKEID
W
A
Q
L
N
H
-----
R
Q
I
E
P
P
-------
369
Blastp_CBE
60.34
35%
-6
- C1 -
-
4L46
6.7
-
KS6B1_HUMAN
A:
[20-313]
-----------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
---
N
-
T
G
K
-
I
F
A
M
K
V
L
K
K
A
M
I
-
V
-
R
-
N
A
K
D
T
A
-
H
T
K
A
E
R
N
I
L
E
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
I
-
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
---
L
N
H
---
Q
---
G
H
---
V
K
L
T
D
F
G
----
L
CKE
S
-
I
H
--
D
----------
H
------
T
-
F
----
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
H
N
-
R
-
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
-
T
I
D
K
I
L
K
---
C
K
L
-
N
L
P
----
P
----
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
GAGPG
D
A
G
E
------
V
Q
A
H
------
P
FFRHIN-----
W
E
E
L
L
A
-----
R
K
V
E
P
P
-------
270
Blastp_CBE
60.27
36%
-82
- C1 -
-
4CT2
5.4
-
PDPK1_HUMAN
A:
[32-296]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
V
E
K
R
H
---------
I
-
P
-
Y
V
Q
R
E
K
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
C
F
Q
D
D
E
K
L
Y
L
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
-
P
-
E
--
S
K
QA
R
-
A
----
N
-
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
G
L
-
I
F
A
K
I
I
K
---
L
E
Y
-
D
F
P
----
E
----
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
470
Blastp_CBE
60.07
34%
-50
- C1 -
-
2JDO
5.7
-
AKT2_HUMAN
A:
[8-307]
----------------------------------------------------------------------------
T
M
---
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
---
A
-
T
G
R
-
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
-
D
E
V
A
-
H
-
T
V
T
-
E
S
R
V
L
Q
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
---
L
D
K
---
D
---
G
H
---
I
K
I
T
D
F
G
----
L
---
C
-
K
E
--
G
-
I
-
S
---
D
--
G
-
A
----
T
-
M
KF--
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
G
-
R
-
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
R
-
L
F
E
L
I
L
M
---
E
E
I
-
R
F
P
----
R
----
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
GGGPS
D
A
K
E
------
V
M
E
H
RFFLSI
N
-----------
W
Q
D
V
V
Q
-----
K
K
L
L
P
P
-------
233
Blastp_CBE
59.92
36%
-81
- C1 -
-
3QC4
10.8
-
PDPK1_HUMAN
B:
[35-299]
---------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
---
L
---
A
-
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
-------------
V
T
R
E
R
D
V
M
S
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
---
D
---
M
H
---
I
Q
I
T
D
F
G
----
T
---
A
K
V
L
--
S
-
P
-
E
--
S
------------
F
----
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
-
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
-
I
F
Q
K
I
I
K
---
L
E
Y
-
D
F
P
----
A
----
A
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
-----
G
C
E
E
MEGYGP
L
K
A
H
------
P
-----------
F
F
E
S
--------------------
364
Blastp_CBE
59.89
35%
1
- C1 -
-
4L44
7.0
-
KS6B1_HUMAN
A:
[20-308]
-----------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
---
N
-
T
G
K
-
I
F
A
M
K
V
L
K
K
A
M
I
-
V
-
R
-
N
A
K
D
T
A
-
H
T
K
A
E
R
N
I
L
E
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
I
-
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
---
L
N
H
---
Q
---
G
H
---
V
K
L
T
D
F
G
----
L
CKE
S
-
I
H
-------------
H
------
T
-
F
----
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
H
N
-
R
-
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
-
T
I
D
K
I
L
K
---
C
K
L
-
N
L
P
----
P
----
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
GAGPG
D
A
G
E
------
V
Q
A
H
------
P
FFRHIN-----
W
E
E
L
L
A
-----
R
K
V
E
P
P
-------
457
Blastp_CBE
59.77
34%
-49
- C1 -
-
3D0E
6.2
-
AKT2_HUMAN
B:
[3-291]
----------------------------------------------------------------------------
T
M
---
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
---
A
-
T
G
R
-
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
-
D
E
V
A
-
H
-
T
V
T
-
E
S
R
V
L
Q
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
---
L
D
K
---
D
---
G
H
---
I
K
I
T
D
F
G
----
L
---
C
-
K
E
--
G
-
I
-
S
---
D
--
G
-
A
----
T
-
M
KF--
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
G
-
R
-
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
R
-
L
F
E
L
I
L
M
---
E
E
I
-
R
F
P
----
R
----
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
GGGPS
D
A
K
E
------
V
M
E
H
RFFLSI
N
-----------
W
Q
D
V
V
Q
-----
K
K
L
L
P
P
-------
469
Blastp_CBE
59.71
34%
-50
- C1 -
-
2JDR
7.1
-
AKT2_HUMAN
A:
[8-305]
----------------------------------------------------------------------------
T
M
---
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
---
A
-
T
G
R
-
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
-
D
E
V
A
-
H
-
T
V
T
-
E
S
R
V
L
Q
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
---
L
D
K
---
D
---
G
H
---
I
K
I
T
D
F
G
----
L
---
C
-
K
E
--
G
-
I
-
S
---
D
--
G
-
A
----
T
-
M
KF--
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
G
-
R
-
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
R
-
L
F
E
L
I
L
M
---
E
E
I
-
R
F
P
----
R
----
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
GGGPS
D
A
K
E
------
V
M
E
H
RFFLSI
N
-----------
W
Q
D
V
V
Q
-----
K
K
L
L
P
P
-------
447
Blastp_CBE
59.67
34%
-48
- C1 -
-
1O6K
5.9
-
AKT2_HUMAN
A:
[3-296]
----------------------------------------------------------------------------
T
M
---
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
---
A
-
T
G
R
-
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
-
D
E
V
A
-
H
-
T
V
T
-
E
S
R
V
L
Q
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
---
L
D
K
---
D
---
G
H
---
I
K
I
T
D
F
G
----
L
---
C
-
K
E
--
G
-
I
-
S
---
D
--
G
-
A
----
T
-
M
KF--
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
G
-
R
-
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
R
-
L
F
E
L
I
L
M
---
E
E
I
-
R
F
P
----
R
----
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
GGGPS
D
A
K
E
------
V
M
E
H
RFFLSI
N
-----------
W
Q
D
V
V
Q
-----
K
K
L
L
P
P
-------
365
Blastp_CBE
59.62
35%
-1
- C1 -
-
4L43
7.1
-
KS6B1_HUMAN
A:
[20-307]
-----------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
---
N
-
T
G
K
-
I
F
A
M
K
V
L
K
K
A
M
I
-
V
-
R
-
N
A
K
D
T
A
-
H
T
K
A
E
R
N
I
L
E
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
I
-
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
---
L
N
H
---
Q
---
G
H
---
V
K
L
T
D
F
G
----
L
CKE
S
-------------------------------
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
H
N
-
R
-
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
-
T
I
D
K
I
L
K
---
C
K
L
-
N
L
P
----
P
----
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
GAGPG
D
A
G
E
------
V
Q
A
H
------
P
FFRHIN-----
W
E
E
L
L
A
-----
R
K
V
E
P
P
-------
570
HHSearch
59.48
33%
-75
- C1 -
-
4EJN
6.7
-
AKT1_HUMAN
A:
[145-413]
---------------------------------------------------------------------------
V
T
M
---
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
---
A
-
T
G
R
-
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
-----------------
V
L
Q
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
-
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
-
V
V
Y
R
D
L
K
L
E
N
L
M
---
L
D
K
---
D
---
G
H
---
I
K
I
T
D
F
G
----
L
---
C
-
K
E
--
G
-
I
-
K
--------
K
----
T
-
F
----
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
G
-
R
-
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
K
-
L
F
E
L
I
L
M
---
E
E
I
-
R
F
P
----
R
----
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
GGGSE
D
A
K
E
------
I
M
Q
H
------
R
-----------
F
F
A
G
I
V
-----
W
------------
223
Blastp_CBE
59.44
37%
-106
- C1 -
-
4YUR
6.0
-
PLK4_HUMAN
A:
[12-269]
-----------------------------------------------------------------------------
I
---
E
D
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
---
I
---
H
-
T
G
L
-
E
V
A
I
K
M
I
D
K
K
A
M
-
Y
-
K
-
A
G
M
V
-
Q
-
R
V
Q
N
E
V
K
I
H
C
Q
L
K
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
R
V
K
P
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
-
H
G
-
I
L
H
R
D
L
T
L
S
N
L
L
---
L
T
R
---
N
---
M
N
---
I
K
I
A
D
F
---------------------------------------------------------
G
-
L
-
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
---
T
V
K
N
-
T
L
N
K
V
V
L
---
A
D
Y
-
E
M
P
----
S
----
F
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
-----
S
L
S
S
------
V
L
D
H
------
P
-----------
F
M
S
---------------------
525
Blastp_CBE
59.38
31%
-80
- C1 -
-
6T6F
5.4
-
?
A:
[16-291]
-----------------------------------------------------------------------------------
F
E
F
K
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
---
K
---
A
-
T
G
K
-
L
F
A
V
K
C
I
P
K
K
A
L
-
K
----
G
K
E
-
S
-
S
I
E
N
E
I
A
V
L
R
K
I
K
H
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
-
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
-
M
G
-
I
V
H
R
D
L
K
P
E
N
L
L
---
Y
Y
S
---
Q
---
D
E
ESK
I
M
I
S
D
F
G
----
L
---
S
---------------------------------
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
-
K
-
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
S
K
-
L
F
E
Q
I
L
K
---
A
E
Y
-
E
F
D
----
S
PYWD
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
-----
T
C
E
Q
------
A
A
R
H
------
P
-----------
W
I
A
G
D
T
------------------
445
Blastp_CBE
59.38
31%
-60
- C1 -
-
4FG8
4.0
-
KCC1A_HUMAN
B:
[18-291]
---------------------------------------------------------------------------------
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
---
K
---
R
-
T
Q
K
-
L
V
A
I
K
C
I
A
K
------------------
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
-
L
G
-
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
D
E
---
D
---
S
K
---
I
M
I
S
D
F
G
------------------
G
--
S
V
--
L
-
S
----
T
-
A
----
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
-
K
-
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
-
L
F
E
Q
I
L
K
---
A
E
Y
-
E
F
D
----
S
PYWD
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
-----
T
C
E
Q
------
A
L
Q
H
------
P
-----------
W
I
A
G
D
T
-------
A
L
D
K
N
I
H
Q
S
V
S
465
Blastp_CBE
59.26
34%
-47
- C1 -
-
1O6L
5.9
-
AKT2_HUMAN
A:
[3-300]
----------------------------------------------------------------------------
T
M
---
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
---
A
-
T
G
R
-
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
-
D
E
V
A
-
H
-
T
V
T
-
E
S
R
V
L
Q
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
---
L
D
K
---
D
---
G
H
---
I
K
I
T
D
F
G
----
L
---
C
-
K
E
--
G
-
I
-
S
---
D
--
G
-
A
----
T
-
M
KF--
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
G
-
R
-
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
R
-
L
F
E
L
I
L
M
---
E
E
I
-
R
F
P
----
R
----
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
GGGPS
D
A
K
E
------
V
M
E
H
RFFLSI
N
-----------
W
Q
D
V
V
Q
-----
K
K
L
L
P
P
-------
468
Blastp_CBE
59.09
34%
-49
- C1 -
-
2UW9
5.8
-
AKT2_HUMAN
A:
[8-305]
----------------------------------------------------------------------------
T
M
---
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
---
A
-
T
G
R
-
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
-
D
E
V
A
-
H
-
T
V
T
-
E
S
R
V
L
Q
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
---
L
D
K
---
D
---
G
H
---
I
K
I
T
D
F
G
----
L
---
C
-
K
E
--
G
-
I
-
S
---
D
--
G
-
A
----
T
-
M
KF--
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
G
-
R
-
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
R
-
L
F
E
L
I
L
M
---
E
E
I
-
R
F
P
----
R
----
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
GGGPS
D
A
K
E
------
V
M
E
H
RFFLSI
N
-----------
W
Q
D
V
V
Q
-----
K
K
L
L
P
P
-------
452
Blastp_CBE
59.08
34%
-46
- C1 -
-
3E8D
5.3
-
AKT2_HUMAN
A:
[3-299]
----------------------------------------------------------------------------
T
M
---
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
---
A
-
T
G
R
-
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
-
D
E
V
A
-
H
-
T
V
T
-
E
S
R
V
L
Q
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
---
L
D
K
---
D
---
G
H
---
I
K
I
T
D
F
G
----
L
---
C
-
K
E
--
G
-
I
-
S
---
D
--
G
-
A
----
T
-
M
KF--
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
G
-
R
-
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
R
-
L
F
E
L
I
L
M
---
E
E
I
-
R
F
P
----
R
----
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
GGGPS
D
A
K
E
------
V
M
E
H
RFFLSI
N
-----------
W
Q
D
V
V
Q
-----
K
K
L
L
P
P
-------
366
Blastp_CBE
59.05
35%
2
- C1 -
-
4L45
6.8
-
KS6B1_HUMAN
A:
[20-306]
-----------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
---
N
-
T
G
K
-
I
F
A
M
K
V
L
K
K
A
M
I
-
V
-
R
-
N
A
K
D
T
A
-
H
T
K
A
E
R
N
I
L
E
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
I
-
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
---
L
N
H
---
Q
---
G
H
---
V
K
L
T
D
F
G
----
L
CKE
S
-------------------------------
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
H
N
-
R
-
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
-
T
I
D
K
I
L
K
---
C
K
L
-
N
L
P
----
P
----
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
GAGPG
D
A
G
E
------
V
Q
A
H
------
P
FFRHIN-----
W
E
E
L
L
A
-----
R
K
V
E
P
P
-------
467
Blastp_CBE
58.78
34%
-48
- C1 -
-
2X39
6.3
-
AKT2_HUMAN
A:
[8-305]
----------------------------------------------------------------------------
T
M
---
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
---
A
-
T
G
R
-
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
-
D
E
V
A
-
H
-
T
V
T
-
E
S
R
V
L
Q
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
---
L
D
K
---
D
---
G
H
---
I
K
I
T
D
F
G
----
L
---
C
-
K
E
--
G
-
I
-
S
---
D
--
G
-
A
----
T
-
M
KF--
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
G
-
R
-
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
R
-
L
F
E
L
I
L
M
---
E
E
I
-
R
F
P
----
R
----
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
GGGPS
D
A
K
E
------
V
M
E
H
RFFLSI
N
-----------
W
Q
D
V
V
Q
-----
K
K
L
L
P
P
-------
451
Blastp_CBE
58.77
34%
-47
- C1 -
-
3E8D
5.7
-
AKT2_HUMAN
B:
[3-297]
----------------------------------------------------------------------------
T
M
---
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
---
A
-
T
G
R
-
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
-
D
E
V
A
-
H
-
T
V
T
-
E
S
R
V
L
Q
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
---
L
D
K
---
D
---
G
H
---
I
K
I
T
D
F
G
----
L
---
C
-
K
E
--
G
-
I
-
S
---
D
--
G
-
A
----
T
-
M
KF--
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
G
-
R
-
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
R
-
L
F
E
L
I
L
M
---
E
E
I
-
R
F
P
----
R
----
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
GGGPS
D
A
K
E
------
V
M
E
H
RFFLSI
N
-----------
W
Q
D
V
V
Q
-----
K
K
L
L
P
P
-------
466
Blastp_CBE
58.63
34%
-49
- C1 -
-
2XH5
7.4
-
AKT2_HUMAN
A:
[8-305]
----------------------------------------------------------------------------
T
M
---
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
---
A
-
T
G
R
-
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
-
D
E
V
A
-
H
-
T
V
T
-
E
S
R
V
L
Q
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
---
L
D
K
---
D
---
G
H
---
I
K
I
T
D
F
G
----
L
---
C
-
K
E
--
G
-
I
-
S
---
D
--
G
-
A
----
T
-
M
KF--
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
G
-
R
-
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
R
-
L
F
E
L
I
L
M
---
E
E
I
-
R
F
P
----
R
----
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
GGGPS
D
A
K
E
------
V
M
E
H
RFFLSI
N
-----------
W
Q
D
V
V
Q
-----
K
K
L
L
P
P
-------
456
Blastp_CBE
58.42
34%
-46
- C1 -
-
3E87
5.9
-
AKT2_HUMAN
A:
[3-292]
----------------------------------------------------------------------------
T
M
---
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
---
A
-
T
G
R
-
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
-
D
E
V
A
-
H
-
T
V
T
-
E
S
R
V
L
Q
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
---
L
D
K
---
D
---
G
H
---
I
K
I
T
D
F
G
----
L
---
C
-
K
E
--
G
-
I
-
S
---
D
--
G
-
A
----
T
-
M
KF--
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
G
-
R
-
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
R
-
L
F
E
L
I
L
M
---
E
E
I
-
R
F
P
----
R
----
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
GGGPS
D
A
K
E
------
V
M
E
H
RFFLSI
N
-----------
W
Q
D
V
V
Q
-----
K
K
L
L
P
P
-------
458
Blastp_CBE
58.39
34%
-48
- C1 -
-
3D0E
6.0
-
AKT2_HUMAN
A:
[3-291]
----------------------------------------------------------------------------
T
M
---
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
---
A
-
T
G
R
-
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
-
D
E
V
A
-
H
-
T
V
T
-
E
S
R
V
L
Q
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
---
L
D
K
---
D
---
G
H
---
I
K
I
T
D
F
G
----
L
---
C
-
K
E
--
G
-
I
-
S
---
D
--
G
-
A
----
T
-
M
KF--
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
G
-
R
-
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
R
-
L
F
E
L
I
L
M
---
E
E
I
-
R
F
P
----
R
----
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
GGGPS
D
A
K
E
------
V
M
E
H
RFFLSI
N
-----------
W
Q
D
V
V
Q
-----
K
K
L
L
P
P
-------
455
Blastp_CBE
58.21
34%
-45
- C1 -
-
3E87
6.0
-
AKT2_HUMAN
B:
[3-292]
----------------------------------------------------------------------------
T
M
---
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
---
A
-
T
G
R
-
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
-
D
E
V
A
-
H
-
T
V
T
-
E
S
R
V
L
Q
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
---
L
D
K
---
D
---
G
H
---
I
K
I
T
D
F
G
----
L
---
C
-
K
E
--
G
-
I
-
S
---
D
--
G
-
A
----
T
-
M
KF--
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
G
-
R
-
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
R
-
L
F
E
L
I
L
M
---
E
E
I
-
R
F
P
----
R
----
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
GGGPS
D
A
K
E
------
V
M
E
H
RFFLSI
N
-----------
W
Q
D
V
V
Q
-----
K
K
L
L
P
P
-------
375
Blastp_CBE
58.17
35%
10
- C1 -
-
3WF6
5.9
-
KS6B1_HUMAN
A:
[21-298]
-----------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
---
N
-
T
G
K
-
I
F
A
M
K
V
L
K
K
----------------
T
K
A
E
R
N
I
L
E
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
I
-
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
---
L
N
H
---
Q
---
G
H
---
V
K
L
T
D
F
G
----
L
CKE
S
-
I
H
--
D
-
G
-
T
--
V
T
--
H
-
T
------
F
----
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
H
N
-
R
-
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
-
T
I
D
K
I
L
K
---
C
K
L
-
N
L
P
----
P
----
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
GAGPG
D
A
G
E
------
V
Q
A
H
------
P
FFRHIN-----
W
E
E
L
L
A
-----
R
K
V
E
P
P
-------
377
Blastp_CBE
58.00
35%
5
- C1 -
-
3WE4
6.7
-
KS6B1_HUMAN
A:
[21-298]
-----------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
---
N
-
T
G
K
-
I
F
A
M
K
V
L
K
K
A
M
I
-
V
-
R
-
N
A
K
D
-
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
I
-
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
---
L
N
H
---
Q
---
G
H
---
V
K
L
T
D
F
G
----
L
CKE
S
-
I
H
--
D
------
V
T
--
H
--------
F
----
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
H
N
-
R
-
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
-
T
I
D
K
I
L
K
---
C
K
L
-
N
L
P
----
P
----
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
GAGPG
D
A
G
E
------
V
Q
A
H
------
P
FFRHIN-----
W
E
E
L
L
A
-----
R
K
V
E
P
P
-------
453
Blastp_CBE
57.84
34%
-44
- C1 -
-
3E88
6.6
-
AKT2_HUMAN
B:
[3-294]
----------------------------------------------------------------------------
T
M
---
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
---
A
-
T
G
R
-
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
-
D
E
V
A
-
H
-
T
V
T
-
E
S
R
V
L
Q
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
---
L
D
K
---
D
---
G
H
---
I
K
I
T
D
F
G
----
L
---
C
-
K
E
--
G
-
I
-
S
---
D
--
G
-
A
----
T
-
M
KF--
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
G
-
R
-
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
R
-
L
F
E
L
I
L
M
---
E
E
I
-
R
F
P
----
R
----
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
GGGPS
D
A
K
E
------
V
M
E
H
RFFLSI
N
-----------
W
Q
D
V
V
Q
-----
K
K
L
L
P
P
-------
374
Blastp_CBE
57.81
35%
6
- C1 -
-
3WF7
6.1
-
KS6B1_HUMAN
A:
[21-298]
-----------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
---
N
-
T
G
K
-
I
F
A
M
K
V
L
K
K
A
M
I
-
V
-
R
-
N
A
K
D
-
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
I
-
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
---
L
N
H
---
Q
---
G
H
---
V
K
L
T
D
F
G
----
L
CKE
S
-
I
H
--
D
------
V
T
--
H
--------
F
----
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
H
N
-
R
-
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
-
T
I
D
K
I
L
K
---
C
K
L
-
N
L
P
----
P
----
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
GAGPG
D
A
G
E
------
V
Q
A
H
------
P
FFRHIN-----
W
E
E
L
L
A
-----
R
K
V
E
P
P
-------
480
Blastp_CBE
57.66
33%
-81
- C1 -
-
6HHF
5.3
-
AKT1_HUMAN
A:
[94-392]
----
E
E
R
E
E
W
T
T
A
I
Q
T
V
A
D
G
L
K
-------------
K
Q
--------------------------------------
V
T
M
---
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
---
A
-
T
G
R
-
Y
Y
A
M
K
I
L
K
K
E
V
I
-----------------------
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
-
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
---
L
D
K
---
D
---
G
H
---
I
K
I
T
D
F
G
----
L
---
C
-
K
------------------------------
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
G
-
R
-
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
K
-
L
F
E
L
I
L
M
---
E
E
I
-
R
F
P
----
R
----
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
-------------------------------------------------------------
376
Blastp_CBE
57.69
35%
9
- C1 -
-
3WF5
5.9
-
KS6B1_HUMAN
A:
[21-298]
-----------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
---
N
-
T
G
K
-
I
F
A
M
K
V
L
K
K
----------------
T
K
A
E
R
N
I
L
E
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
I
-
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
---
L
N
H
---
Q
---
G
H
---
V
K
L
T
D
F
G
----
L
CKE
S
-
I
H
--
D
-
G
-
T
--
V
T
--
H
-
T
------
F
----
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
H
N
-
R
-
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
-
T
I
D
K
I
L
K
---
C
K
L
-
N
L
P
----
P
----
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
GAGPG
D
A
G
E
------
V
Q
A
H
------
P
FFRHIN-----
W
E
E
L
L
A
-----
R
K
V
E
P
P
-------
454
Blastp_CBE
57.66
34%
-43
- C1 -
-
3E88
6.8
-
AKT2_HUMAN
A:
[3-294]
----------------------------------------------------------------------------
T
M
---
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
---
A
-
T
G
R
-
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
-
D
E
V
A
-
H
-
T
V
T
-
E
S
R
V
L
Q
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
---
L
D
K
---
D
---
G
H
---
I
K
I
T
D
F
G
----
L
---
C
-
K
E
--
G
-
I
-
S
---
D
--
G
-
A
----
T
-
M
KF--
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
G
-
R
-
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
R
-
L
F
E
L
I
L
M
---
E
E
I
-
R
F
P
----
R
----
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
GGGPS
D
A
K
E
------
V
M
E
H
RFFLSI
N
-----------
W
Q
D
V
V
Q
-----
K
K
L
L
P
P
-------
222
Blastp_CBE
57.63
37%
-82
- C1 -
-
3COK
5.7
-
PLK4_HUMAN
A:
[10-267]
-----------------------------------------------------------------------------
I
---
E
D
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
---
I
---
H
-
T
G
L
-
E
V
A
I
K
M
I
D
K
K
A
M
-
Y
-
K
-
A
G
M
V
-
Q
-
R
V
Q
N
E
V
K
I
H
C
Q
L
K
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
R
V
K
P
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
-
H
G
-
I
L
H
R
D
L
T
L
S
N
L
L
---
L
T
R
---
N
---
M
N
---
I
K
I
A
D
F
G
----
L
---
A
-
T
Q
LK----------------------------------------------
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
D
T
D
T
V
------
K
V
V
L
---
A
D
Y
-
E
M
P
----
S
----
F
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
-----
S
L
S
S
------
V
L
D
H
------
P
-----------
F
M
S
---------------------
349
Blastp_CBE
57.57
35%
17
- C1 -
-
5T6K
3.8
-
?
A:
[62-362]
----------------------------------------------------------------------------
T
A
IFS
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
---
K
---
I
-
T
G
Q
-
E
C
A
V
K
V
I
S
K
R
Q
V
-
K
-
Q
-
K
T
D
K
-
E
-
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
-
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
---
K
---
S
K
DAN
I
R
I
I
D
F
G
----
L
---
S
-
T
H
F-
E
-
A
----
K
K
--
M
-
K
----
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
---
G
K
Y
-
T
F
E
LPQW
K
----
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
------
A
L
D
H
------
E
-----------
W
I
Q
T
Y
T
-----
K
------------
347
Blastp_CBE
57.54
35%
15
- C1 -
-
4MX9
4.9
-
?
A:
[21-297]
---------------------------------------------------------------------------
S
T
A
IFS
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
---
K
---
I
-
T
G
Q
-
E
C
A
V
K
V
I
S
K
R
Q
V
-
K
-
Q
-
K
T
D
K
-
E
-
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
Y
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
-
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
---
K
---
S
K
DAN
I
R
I
I
D
F
G
----
L
---
S
-
T
H
F-
E
-
A
-
S
--
K
K
--
M
-
K
----
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
---
G
K
Y
-
T
F
E
LPQW
K
----
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
------
A
L
D
H
------
E
-----------
W
I
Q
T
Y
T
-----
K
------------
221
Blastp_CBE
57.52
37%
-90
- C1 -
-
3COK
5.1
-
PLK4_HUMAN
B:
[10-267]
-----------------------------------------------------------------------------
I
---
E
D
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
---
I
---
H
-
T
G
L
-
E
V
A
I
K
M
I
D
K
K
A
M
-
Y
-
K
-
A
G
M
V
-
Q
-
R
V
Q
N
E
V
K
I
H
C
Q
L
K
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
R
V
K
P
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
-
H
G
-
I
L
H
R
D
L
T
L
S
N
L
L
---
L
T
R
---
N
---
M
N
---
I
K
I
A
D
F
G
----
L
---
A
-
T
Q
LK--------------------------------------------
L
-
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
------
N
-
T
L
N
K
V
V
L
---
A
D
Y
-
E
M
P
----
S
----
F
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
-----
S
L
S
S
------
V
L
D
H
------
P
-----------
F
M
S
---------------------
443
Blastp_CBE
57.45
31%
-89
- C1 -
-
4FG7
4.5
-
KCC1A_HUMAN
A:
[18-277]
---------------------------------------------------------------------------------
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
---
K
---
R
-
T
Q
K
-
L
V
A
I
K
C
I
A
----------------
S
M
E
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
-
L
G
-
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
D
E
---
D
---
S
K
---
I
M
I
S
D
F
G
----
L
---
S
K
M
E
--
D
-
P
-----------------------
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
--
S
-
K
-
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
-
L
F
E
Q
I
L
K
---
A
E
Y
-
E
F
D
----
S
PYWD
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
-----
T
C
E
Q
------
A
L
Q
H
------
P
-----------
W
I
A
---------------------
341
Blastp_CBE
57.41
35%
21
- C1 -
-
4IHP
4.9
-
?
A:
[44-323]
----------------------------------------------------------------------------
T
A
IFS
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
---
K
---
I
-
T
G
Q
-
E
C
A
V
K
V
I
S
K
R
Q
V
-
K
-
Q
-
K
T
D
K
-
E
-
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
-
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
---
K
---
S
K
DAN
I
R
I
I
D
F
G
----
L
---
S
-
T
H
F-
E
-
A
-
S
--
K
K
--
M
-
K
----
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
---
G
K
Y
-
T
F
E
LPQW
K
----
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
------
A
L
D
H
------
E
-----------
W
I
Q
T
Y
T
-----
K
------------
240
Blastp_CBE
57.38
35%
15
- C1 -
-
5W91
5.7
-
?
A:
[20-304]
---------------------------------------------------------------------------
S
T
A
IFS
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
---
K
---
I
-
T
G
Q
-
E
C
A
V
K
V
I
S
K
R
Q
V
-
K
-
Q
-
K
T
D
K
-
E
-
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
-
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
---
K
---
S
K
DAN
I
R
I
I
D
F
G
----
L
---
S
-
T
H
F-
E
-
A
-
S
--
K
K
--
M
-
K
----
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
---
G
K
Y
-
T
F
E
LPQW
K
----
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
------
A
L
D
H
------
E
-----------
W
I
Q
T
Y
T
-----
K
------------
238
Blastp_CBE
57.37
35%
17
- C1 -
-
5W9R
6.4
-
?
A:
[21-309]
----------------------------------------------------------------------------
T
A
IFS
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
---
K
---
I
-
T
G
Q
-
E
C
A
V
K
V
I
S
K
R
Q
V
-
K
-
Q
-
K
T
D
K
-
E
-
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
-
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
---
K
---
S
K
DAN
I
R
I
I
D
F
G
----
L
---
S
-
T
H
F-
E
-
A
-
S
--
K
K
--
M
-
K
----
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
---
G
K
Y
-
T
F
E
LPQW
K
----
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
------
A
L
D
H
------
E
-----------
W
I
Q
T
Y
T
-----
K
------------
352
Blastp_CBE
57.07
35%
17
- C1 -
-
5JN2
5.6
-
?
A:
[61-346]
---------------------------------------------------------------------------
S
T
A
IFS
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
---
K
---
I
-
T
G
Q
-
E
C
A
V
K
V
I
S
K
R
Q
V
-
K
-
Q
-
K
T
D
K
-
E
-
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
-
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
---
K
---
S
K
DAN
I
R
I
I
D
F
G
----
L
---
S
-
T
H
F-
E
-
A
-
S
--
K
K
--
M
-
K
----
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
---
G
K
Y
-
T
F
E
LPQW
K
----
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
------
A
L
D
H
------
E
-----------
W
I
Q
T
Y
T
-----
K
------------
346
Blastp_CBE
57.00
35%
19
- C1 -
-
4MXA
5.2
-
?
A:
[21-297]
---------------------------------------------------------------------------
S
T
A
IFS
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
---
K
---
I
-
T
G
Q
-
E
C
A
V
K
V
I
S
K
R
Q
V
-
K
-
Q
-
K
T
D
K
-
E
-
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
Y
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
-
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
---
K
---
S
K
DAN
I
R
I
I
D
F
G
----
L
---
S
-
T
H
F-
E
-
A
-
S
--
K
K
--
M
-
K
----
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
---
G
K
Y
-
T
F
E
LPQW
K
----
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
------
A
L
D
H
------
E
-----------
W
I
Q
T
Y
T
-----
K
------------
242
Blastp_CBE
56.98
35%
14
- C1 -
-
5W80
5.9
-
?
A:
[21-301]
----------------------------------------------------------------------------
T
A
IFS
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
---
K
---
I
-
T
G
Q
-
E
C
A
V
K
V
I
S
K
R
Q
V
-
K
-
Q
-
K
T
D
K
-
E
-
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
-
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
---
K
---
S
K
DAN
I
R
I
I
D
F
G
----
L
---
S
-
T
H
F-
E
-
A
-
S
--
K
K
--
M
-
K
----
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
---
G
K
Y
-
T
F
E
LPQW
K
----
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
------
A
L
D
H
------
E
-----------
W
I
Q
T
Y
T
-----
K
------------
448
Blastp_CBE
56.83
31%
-58
- C1 -
-
4FG9
5.2
-
KCC1A_HUMAN
B:
[18-291]
---------------------------------------------------------------------------------
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
---
K
---
R
-
T
Q
K
-
L
V
A
I
K
C
I
A
K
-------------------
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
-
L
G
-
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
D
E
---
D
---
S
K
---
I
M
I
S
D
F
-----------------------
V
--
L
-
S
----
T
-
A
----
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
-
K
-
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
-
L
F
E
Q
I
L
K
---
A
E
Y
-
E
F
D
----
S
PYWD
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
-----
T
C
E
Q
------
A
L
Q
H
------
P
-----------
W
I
A
G
D
T
-------
A
L
D
K
N
I
H
Q
S
V
S
239
Blastp_CBE
56.86
35%
12
- C1 -
-
5W9E
5.3
-
?
A:
[21-303]
----------------------------------------------------------------------------
T
A
IFS
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
---
K
---
I
-
T
G
Q
-
E
C
A
V
K
V
I
S
K
R
Q
V
-
K
-
Q
-
K
T
D
K
-
E
-
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
-
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
---
K
---
S
K
DAN
I
R
I
I
D
F
G
----
L
---
S
-
T
H
F-
E
-
A
-
S
--
K
K
--
M
-
K
----
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
---
G
K
Y
-
T
F
E
LPQW
K
----
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
------
A
L
D
H
------
E
-----------
W
I
Q
T
Y
T
-----
K
------------
224
Blastp_CBE
56.83
37%
-76
- C1 -
-
4JXF
3.4
-
PLK4_HUMAN
A:
[6-264]
-----------------------------------------------------------------------------
I
---
E
D
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
---
I
---
H
-
T
G
L
-
E
V
A
I
K
M
I
D
K
K
A
M
-
Y
-
K
-
A
G
M
V
-
Q
-
R
V
Q
N
E
V
K
I
H
C
Q
L
K
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
R
V
K
P
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
-
H
G
-
I
L
H
R
D
L
T
L
S
N
L
L
---
L
T
R
---
N
---
M
N
---
I
K
I
A
D
F
G
----
L
---
A
-
T
Q
LK
M
-
P
-
H
-----------------------------------------
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
----
V
K
N
-
T
L
N
K
V
V
L
---
A
D
Y
-
E
M
P
----
S
----
F
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
-----
S
L
S
S
------
V
L
D
H
------
P
-----------
F
M
S
R
--------------------
353
Blastp_CBE
56.77
35%
20
- C1 -
-
5JMS
6.4
-
?
A:
[62-348]
----------------------------------------------------------------------------
T
A
IFS
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
---
K
---
I
-
T
G
Q
-
E
C
A
V
K
V
I
S
K
R
Q
V
-
K
-
Q
-
K
T
D
K
-
E
-
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
-
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
---
K
---
S
K
DAN
I
R
I
I
D
F
G
----
L
---
S
-
T
H
F-
E
-
A
-
S
--
K
K
--
M
-
K
----
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
---
G
K
Y
-
T
F
E
LPQW
K
----
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
------
A
L
D
H
------
E
-----------
W
I
Q
T
Y
T
-----
K
------------
255
Blastp_CBE
56.74
35%
18
- C1 -
-
3UPX
6.3
-
?
A:
[21-309]
----------------------------------------------------------------------------
T
A
IFS
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
---
K
---
I
-
T
G
Q
-
E
C
A
V
K
V
I
S
K
R
Q
V
-
K
-
Q
-
K
T
D
K
-
E
-
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
-
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
---
K
---
S
K
DAN
I
R
I
I
D
F
G
----
L
---
S
-
T
H
F-
E
-
A
-
S
--
K
K
--
M
-
K
----
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
---
G
K
Y
-
T
F
E
LPQW
K
----
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
------
A
L
D
H
------
E
-----------
W
I
Q
T
Y
T
-----
K
------------
351
Blastp_CBE
56.70
35%
16
- C1 -
-
5T6A
5.8
-
?
A:
[63-362]
-----------------------------------------------------------------------------
A
IFS
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
---
K
---
I
-
T
G
Q
-
E
C
A
V
K
V
I
S
K
R
Q
V
-
K
-
Q
-
K
T
D
K
-
E
-
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
-
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
---
K
---
S
K
DAN
I
R
I
I
D
F
G
----
L
---
S
-
T
H
F-
E
-
A
----
K
K
--
M
-
K
----
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
---
G
K
Y
-
T
F
E
LPQW
K
----
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
------
A
L
D
H
------
E
-----------
W
I
Q
T
Y
T
-----
K
------------
419
Blastp_CBE
56.68
34%
25
- C1 -
-
4YZB
6.3
-
?
B:
[12-299]
-------------------------------------------------------
K
L
----
A
A
T
P
G
M
F
----
V
Q
H
S
T
A
AFS
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
---
K
---
V
-
T
G
Q
-
E
Y
A
V
K
V
I
S
K
R
-----
Q
-
K
T
D
K
-
E
-
L
L
L
K
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
-
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
N
---
K
RKD
A
N
---
I
R
I
I
D
F
G
----
L
---
S
-
T
H
--
F
-
E
-
S
--
T
K
--
K
M
K
----
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
F
D
-
I
L
K
K
V
E
K
---
G
K
F
-
T
F
D
LPQW
K
----
K
V
S
E
P
A
K
D
L
I
R
K
M
L
A
Y
V
P
T
M
R
I
-----
S
A
R
D
------
A
L
E
H
------
E
-----------
W
L
K
T
T
D
------------------
257
Blastp_CBE
56.64
35%
17
- C1 -
-
3T3U
4.8
-
?
A:
[22-301]
-----------------------------------------------------------------------------
A
IFS
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
---
K
---
I
-
T
G
Q
-
E
C
A
V
K
V
I
S
K
R
Q
V
-
K
-
Q
-
K
T
D
K
-
E
-
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
-
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
---
K
---
S
K
DAN
I
R
I
I
D
F
G
----
L
---
S
-
T
H
F-
E
-
A
-
S
--
K
K
--
M
-
K
----
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
---
G
K
Y
-
T
F
E
LPQW
K
----
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
------
A
L
D
H
------
E
-----------
W
I
Q
T
Y
T
-----
K
------------
344
Blastp_CBE
56.61
35%
14
- C1 -
-
3KU2
4.8
-
?
A:
[44-320]
----------------------------------------------------------------------------
T
A
IFS
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
---
K
---
I
-
T
G
Q
-
E
C
A
V
K
V
I
S
K
R
Q
V
-
K
-
Q
-
K
T
D
K
-
E
-
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
-
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
---
K
---
S
K
DAN
I
R
I
I
D
F
G
----
L
---
S
-
T
H
F-
E
-
A
-
S
--
K
K
--
M
-
K
----
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
---
G
K
Y
-
T
F
E
LPQW
K
----
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
------
A
L
D
H
------
E
-----------
W
I
Q
T
Y
T
-----
K
------------
256
Blastp_CBE
56.48
35%
16
- C1 -
-
3T3V
4.8
-
?
A:
[22-300]
-----------------------------------------------------------------------------
A
IFS
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
---
K
---
I
-
T
G
Q
-
E
C
A
V
K
V
I
S
K
R
Q
V
-
K
-
Q
-
K
T
D
K
-
E
-
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
-
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
---
K
---
S
K
DAN
I
R
I
I
D
F
G
----
L
---
S
-
T
H
F-
E
-
A
-
S
--
K
K
--
M
-
K
----
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
---
G
K
Y
-
T
F
E
LPQW
K
----
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
------
A
L
D
H
------
E
-----------
W
I
Q
T
Y
T
-----
K
------------
249
Blastp_CBE
56.48
35%
19
- C1 -
-
4M84
4.3
-
?
A:
[21-290]
----------------------------------------------------------------------------
T
A
IFS
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
---
K
---
I
-
T
G
Q
-
E
C
A
V
K
V
I
S
K
R
Q
V
-
K
-
Q
-
K
T
D
K
-
E
-
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
-
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
---
K
---
S
K
DAN
I
R
I
I
D
F
G
----
L
---
S
-
T
H
F-
E
-
A
-
S
--
K
K
--
M
-
K
----
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
---
G
K
Y
-
T
F
E
LPQW
K
----
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
------
A
L
D
H
------
E
-----------
W
I
Q
T
Y
T
-----
K
------------
471
Blastp_CBE
56.44
35%
-68
- C1 -
-
3NYV
6.1
-
?
A:
[26-299]
---------------------------------------------------------------------------------
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
---
K
---
I
-
T
G
Q
-
E
C
A
V
K
V
I
S
K
R
Q
V
-
K
-
Q
-
K
T
D
K
-
E
-
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
-
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
---
K
---
S
K
DAN
I
R
I
I
D
F
G
----
L
---
S
-
T
H
--
F
-
E
-
A
--
S
K
--
K
-
K
----
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
---
G
K
Y
-
T
F
E
LPQW
K
----
K
V
S
E
S
A
K
D
L
I
R
K
L
T
-
Y
V
P
S
-
R
I
-----
S
A
R
D
------
A
L
D
H
------
E
-----------
W
I
Q
T
Y
T
-----
K
------------
237
Blastp_CBE
56.41
35%
19
- C1 -
-
6BFA
4.6
-
?
A:
[21-290]
----------------------------------------------------------------------------
T
A
IFS
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
---
K
---
I
-
T
G
Q
-
E
C
A
V
K
V
I
S
K
R
Q
V
-
K
-
Q
-
K
T
D
K
-
E
-
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
-
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
---
K
---
S
K
DAN
I
R
I
I
D
F
G
----
L
---
S
-
T
H
F-
E
-
A
-
S
--
K
K
--
M
-
K
----
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
---
G
K
Y
-
T
F
E
LPQW
K
----
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
------
A
L
D
H
------
E
-----------
W
I
Q
T
Y
T
-----
K
------------
342
Blastp_CBE
56.38
35%
16
- C1 -
-
4IH8
6.0
-
?
A:
[45-341]
-----------------------------------------------------------------------------
A
IFS
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
---
K
---
I
-
T
G
Q
-
E
C
A
V
K
V
I
S
K
R
Q
V
-
K
-
Q
-
K
T
D
K
-
E
-
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
-
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
--------
S
K
DAN
I
R
I
I
D
F
G
----
L
---
S
-
T
H
F-
E
-
A
-
S
--
K
K
--
M
-
K
----
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
---
G
K
Y
-
T
F
E
LPQW
K
----
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
------
A
L
D
H
------
E
-----------
W
I
Q
T
Y
T
-----
K
------------
263
Blastp_CBE
56.37
35%
40
- C1 -
-
4IEB
4.6
-
?
A:
[35-314]
---------------------------------------------------------------
T
P
G
M
F
----
V
Q
H
S
T
A
IFS
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
---
K
---
I
-
T
G
Q
-
E
C
A
V
K
V
I
S
K
R
Q
V
------
T
D
K
-
E
-
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
M
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
-
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
---
K
---
S
K
DAN
I
R
I
I
D
F
G
----
L
---
S
-
T
H
F-
E
-
A
-
S
--
K
K
--
M
-
K
----
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
---
G
K
Y
-
T
F
E
PQW-
K
----
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
------
A
L
D
H
------
E
-----------
W
I
Q
T
Y
T
-----
K
------------
245
Blastp_CBE
56.36
35%
17
- C1 -
-
4WG4
6.3
-
?
A:
[20-301]
---------------------------------------------------------------------------
S
T
A
IFS
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
---
K
---
I
-
T
G
Q
-
E
C
A
V
K
V
I
S
K
R
Q
V
-
K
-
Q
-
K
T
D
K
-
E
-
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
-
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
---
K
---
S
K
DAN
I
R
I
I
D
F
G
----
L
---
S
-
T
H
F-
E
-
A
-
S
--
K
K
--
M
-
K
----
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
---
G
K
Y
-
T
F
E
LPQW
K
----
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
------
A
L
D
H
------
E
-----------
W
I
Q
T
Y
T
-----
K
------------
258
Blastp_CBE
56.35
35%
16
- C1 -
-
3SXF
4.2
-
?
A:
[22-301]
-----------------------------------------------------------------------------
A
IFS
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
---
K
---
I
-
T
G
Q
-
E
C
A
V
K
V
I
S
K
R
Q
V
-
K
-
Q
-
K
T
D
K
-
E
-
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
-
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
---
K
---
S
K
DAN
I
R
I
I
D
F
G
----
L
---
S
-
T
H
F-
E
-
A
-
S
--
K
K
--
M
-
K
----
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
---
G
K
Y
-
T
F
E
LPQW
K
----
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
------
A
L
D
H
------
E
-----------
W
I
Q
T
Y
T
-----
K
------------
248
Blastp_CBE
56.23
35%
19
- C1 -
-
4ONA
4.4
-
?
A:
[20-290]
---------------------------------------------------------------------------
S
T
A
IFS
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
---
K
---
I
-
T
G
Q
-
E
C
A
V
K
V
I
S
K
R
Q
V
-
K
-
Q
-
K
T
D
K
-
E
-
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
-
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
---
K
---
S
K
DAN
I
R
I
I
D
F
G
----
L
---
S
-
T
H
F-
E
-
A
-
S
--
K
K
--
M
-
K
----
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
---
G
K
Y
-
T
F
E
LPQW
K
----
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
------
A
L
D
H
------
E
-----------
W
I
Q
T
Y
T
-----
K
------------
350
Blastp_CBE
56.06
35%
19
- C1 -
-
5T6I
5.2
-
?
A:
[62-365]
----------------------------------------------------------------------------
T
A
IFS
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
---
K
---
I
-
T
G
Q
-
E
C
A
V
K
V
I
S
K
--
V
-
K
-
Q
-
K
T
D
K
-
E
-
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
-
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
---
K
---
S
K
AN-
I
R
I
I
D
F
G
----
L
---
S
-
T
H
F-
E
-
A
-
S
--
K
K
--
M
-
K
----
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
---
G
K
Y
-
T
F
E
LPQW
K
----
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
------
A
L
D
H
------
E
-----------
W
I
Q
T
Y
T
-----
K
------------
343
Blastp_CBE
56.03
35%
13
- C1 -
-
4IFG
6.0
-
?
A:
[44-325]
----------------------------------------------------------------------------
T
A
IFS
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
---
K
---
I
-
T
G
Q
-
E
C
A
V
K
V
I
S
K
R
Q
V
-
K
-
Q
-
K
T
D
K
-
E
-
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
-
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
---
K
---
S
K
DAN
I
R
I
I
D
F
G
----
L
---
S
-
T
H
F-
E
-
A
-
S
--
K
K
--
M
-
K
----
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
---
G
K
Y
-
T
F
E
LPQW
K
----
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
------
A
L
D
H
------
E
-----------
W
I
Q
T
Y
T
-----
K
------------
345
Blastp_CBE
56.05
35%
31
- C1 -
-
3HX4
4.3
-
?
A:
[36-314]
---------------------------------------------------------------
T
P
G
M
F
----
V
Q
H
S
T
A
IFS
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
---
K
---
I
-
T
G
Q
-
E
C
A
V
K
V
I
S
K
----------
D
K
-
E
-
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
-
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
---
K
---
S
K
DAN
I
R
I
I
D
F
G
----
L
---
S
-
T
H
F-
E
-
A
-
S
--
K
K
--
M
-
K
----
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
---
G
K
Y
-
T
F
E
LPQW
K
----
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
------
A
L
D
H
------
E
-----------
W
I
Q
T
Y
T
-----
K
------------
259
Blastp_CBE
56.03
35%
17
- C1 -
-
3SX9
5.8
-
?
A:
[19-299]
--------------------------------------------------------------------------
H
S
T
A
IFS
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
---
K
---
I
-
T
G
Q
-
E
C
A
V
K
V
I
S
K
R
Q
V
-
K
-
Q
-
K
T
D
K
-
E
-
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
-
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
---
K
---
S
K
DAN
I
R
I
I
D
F
G
----
L
---
S
-
T
H
F-
E
-
A
-
S
--
K
K
--
M
-
K
----
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
---
G
K
Y
-
T
F
E
LPQW
K
----
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
------
A
L
D
H
------
E
-----------
W
I
Q
T
Y
T
-----
K
------------
371
Blastp_CBE
55.97
35%
-8
- C1 -
-
3A62
9.0
-
KS6B1_HUMAN
A:
[19-296]
-----------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
---
N
-
T
G
K
-
I
F
A
M
K
V
L
K
K
------------------
A
E
R
N
I
L
E
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
I
-
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
---
L
N
H
---
Q
---
G
H
---
V
K
L
T
D
F
G
----
L
CKE--------------------------
F
----
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
H
N
-
R
-
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
-
T
I
D
K
I
L
K
---
C
K
L
-
N
L
P
----
P
----
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
GAGPG
D
A
G
E
------
V
Q
A
H
------
P
FFRHIN-----
W
E
E
L
L
A
-----
R
K
V
E
P
P
-------
241
Blastp_CBE
55.86
35%
16
- C1 -
-
5W8R
6.5
-
?
A:
[21-298]
----------------------------------------------------------------------------
T
A
IFS
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
---
K
---
I
-
T
G
Q
-
E
C
A
V
K
V
I
S
K
R
Q
V
-
K
-
Q
-
K
T
D
K
-
E
-
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
-
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
---
K
---
S
K
DAN
I
R
I
I
D
F
G
----
L
---
S
-
T
H
F-
E
-
A
-
S
--
K
K
--
M
-
K
----
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
---
G
K
Y
-
T
F
E
LPQW
K
----
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
------
A
L
D
H
------
E
-----------
W
I
Q
T
Y
T
-----
K
------------
261
Blastp_CBE
55.82
35%
19
- C1 -
-
3I7B
6.4
-
?
A:
[23-293]
------------------------------------------------------------------------------IFS
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
---
K
---
I
-
T
G
Q
-
E
C
A
V
K
V
I
S
K
R
Q
V
-
K
-
Q
-
K
T
D
K
-
E
-
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
-
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
---
K
---
S
K
DAN
I
R
I
I
D
F
G
----
L
---
S
-
T
H
F-
E
-
A
-
S
--
K
K
--
M
-
K
----
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
---
G
K
Y
-
T
F
E
LPQW
K
----
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
------
A
L
D
H
------
E
-----------
W
I
Q
T
Y
T
-----
K
------------
244
Blastp_CBE
55.82
35%
20
- C1 -
-
4WG5
4.0
-
?
A:
[21-290]
----------------------------------------------------------------------------
T
A
IFS
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
---
K
---
I
-
T
G
Q
-
E
C
A
V
K
V
I
S
K
R
Q
V
-
K
-
Q
-
K
T
D
K
-
E
-
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
-
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
---
K
---
S
K
DAN
I
R
I
I
D
F
G
----
L
---
S
-
T
H
F-
E
-
A
-
S
--
K
K
--
M
-
K
----
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
---
G
K
Y
-
T
F
E
LPQW
K
----
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
------
A
L
D
H
------
E
-----------
W
I
Q
T
Y
T
-----
K
------------
426
Blastp_CBE
55.61
34%
24
- C1 -
-
4YSJ
6.0
-
?
A:
[12-298]
-------------------------------------------------------
K
L
----
A
A
T
P
G
M
F
----
V
Q
H
S
T
A
AFS
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
---
K
---
V
-
T
G
Q
-
E
Y
A
V
K
V
I
S
K
R
---------------
L
L
K
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
-
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
N
---
K
RKD
A
N
---
I
R
I
I
D
F
G
----
L
---
S
-
T
H
--
F
-
E
-
S
--
T
K
--
K
M
K
----
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
F
D
-
I
L
K
K
V
E
K
---
G
K
F
-
T
F
D
LPQW
K
----
K
V
S
E
P
A
K
D
L
I
R
K
M
L
A
Y
V
P
T
M
R
I
-----
S
A
R
D
------
A
L
E
H
------
E
-----------
W
L
K
T
T
D
------------------
414
Blastp_CBE
55.57
34%
-34
- C1 -
-
3AMA
6.6
-
KAPCA_HUMAN
A:
[41-302]
-----------------------------------------------------------------------------
L
---
D
Q
F
E
R
I
R
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
K
---
E
-
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
-
K
L
K
Q
I
E
-
H
-
T
L
N
-
E
K
R
I
Q
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
Q
---
Q
---
G
Y
---
I
K
V
A
D
F
G
----
F
---
A
-
K
R
--
V
-
K
-
G
------
R
-
T
----
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
-
I
Y
E
K
I
V
S
---
G
K
V
-
R
F
P
----
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
------
I
K
N
H
------
K
-----------
W
-----------------------
446
Blastp_CBE
55.55
31%
-62
- C1 -
-
4FG8
5.7
-
KCC1A_HUMAN
A:
[18-291]
---------------------------------------------------------------------------------
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
---
K
---
R
-
T
Q
K
-
L
V
A
I
K
C
I
A
K
-----------------
E
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
-
L
G
-
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
D
E
---
D
---
S
K
---
I
M
I
S
D
F
------------------------------------------
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
-
K
-
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
-
L
F
E
Q
I
L
K
---
A
E
Y
-
E
F
D
----
S
PYWD
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
-----
T
C
E
Q
------
A
L
Q
H
------
P
-----------
W
I
A
G
D
T
-------
A
L
D
K
N
I
H
Q
S
V
S
407
Blastp_CBE
55.38
33%
-7
- C1 -
-
5D9L
4.9
-
KS6A3_HUMAN
A:
[32-307]
-----------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
---
D
-
A
R
Q
-
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
-
D
R
V
R
-
T
-
K
M
E
R
D
I
L
V
E
--
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
---
L
D
E
---
E
---
G
H
---
I
K
L
T
D
F
G
----
L
---
S
-
K
E
----------------------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
H
T
-
Q
-
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
E
-
T
M
T
M
I
L
K
---
A
K
L
-
G
M
P
----
Q
----
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
GAGPD
G
V
E
E
------
I
K
R
H
------
S
FFSTID-----
W
N
K
L
Y
R
-----
R
E
I
H
P
P
-------
236
Blastp_CBE
55.38
35%
29
- C1 -
-
3MA6
4.7
-
?
A:
[29-296]
------------------------------------------------------------------------------IFS
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
---
K
---
I
-
T
G
Q
-
E
C
A
V
K
V
I
S
K
R
Q
V
-
K
-
Q
-
K
T
D
K
-
E
-
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
-
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
---
K
---
S
K
DAN
I
R
I
I
D
F
G
----
L
---
S
-
T
H
F-
E
---
S
--
K
K
--
M
-
K
----
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
---
G
K
Y
-
T
F
E
LPQW
K
----
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
------
A
L
D
H
------
E
-----------
W
I
Q
T
Y
T
-----
K
------------
449
Blastp_CBE
55.30
31%
-62
- C1 -
-
4FG9
5.9
-
KCC1A_HUMAN
A:
[18-291]
---------------------------------------------------------------------------------
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
---
K
---
R
-
T
Q
K
-
L
V
A
I
K
C
I
A
K
E
----------------
E
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
-
L
G
-
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
D
E
---
D
---
S
K
---
I
M
I
S
D
F
-------------------------------------------
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
-
K
-
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
-
L
F
E
Q
I
L
K
---
A
E
Y
-
E
F
D
----
S
PYWD
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
-----
T
C
E
Q
------
A
L
Q
H
------
P
-----------
W
I
A
G
D
T
-------
A
L
D
K
N
I
H
Q
S
V
S
413
Blastp_CBE
55.26
34%
-38
- C1 -
-
3AMB
7.0
-
KAPCA_HUMAN
A:
[41-302]
-----------------------------------------------------------------------------
L
---
D
Q
F
E
R
I
R
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
K
---
E
-
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
-
K
L
K
Q
I
E
-
H
-
T
L
N
-
E
K
R
I
Q
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
Q
---
Q
---
G
Y
---
I
K
V
A
D
F
G
----
F
---
A
-
K
R
--
V
-
K
-
G
------
R
-
T
----
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
-
I
Y
E
K
I
V
S
---
G
K
V
-
R
F
P
----
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
------
I
K
N
H
------
K
-----------
W
-----------------------
260
Blastp_CBE
55.26
35%
18
- C1 -
-
3N51
6.0
-
?
A:
[22-305]
-----------------------------------------------------------------------------
A
IFS
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
---
K
---
I
-
T
G
Q
-
E
C
A
V
K
V
I
S
K
R
Q
V
-
K
-
Q
-
K
T
D
K
-
E
-
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
-
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
---
K
---
S
K
DAN
I
R
I
I
D
F
G
----
L
---
S
-
T
H
F-
E
-
A
-
S
--
K
K
--
M
-
K
----
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
---
G
K
Y
-
T
F
E
LPQW
K
----
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
------
A
L
D
H
------
E
-----------
W
I
Q
T
Y
T
-----
K
------------
252
Blastp_CBE
55.16
35%
18
- C1 -
-
3V5P
5.5
-
?
A:
[20-305]
---------------------------------------------------------------------------
S
T
A
IFS
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
---
K
---
I
-
T
G
Q
-
E
C
A
V
K
V
I
S
K
R
Q
V
-
K
-
Q
-
K
T
D
K
-
E
-
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
-
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
---
K
---
S
K
DAN
I
R
I
I
D
F
G
----
L
---
S
-
T
H
F-
E
-
A
-
S
--
K
K
--
M
-
K
----
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
---
G
K
Y
-
T
F
E
LPQW
K
----
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
------
A
L
D
H
------
E
-----------
W
I
Q
T
Y
T
-----
K
------------
442
Blastp_CBE
55.05
34%
-34
- C1 -
-
6FRX
7.4
-
KAPCA_HUMAN
A:
[41-302]
-----------------------------------------------------------------------------
L
---
D
Q
F
E
R
I
R
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
K
---
E
-
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
-
K
L
K
Q
I
E
-
H
-
T
L
N
-
E
K
R
I
Q
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
Q
---
Q
---
G
Y
---
I
K
V
A
D
F
G
----
F
---
A
-
K
R
--
V
-
K
-
G
------
R
-
T
----
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
-
I
Y
E
K
I
V
S
---
G
K
V
-
R
F
P
----
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
------
I
K
N
H
------
K
-----------
W
-----------------------
380
Blastp_CBE
54.92
34%
4
- C1 -
-
6G77
7.0
-
KS6A6_HUMAN
A:
[31-304]
-----------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
---
K
TGP
D
-
A
G
Q
-
L
Y
A
M
K
V
L
K
K
A
S
L
-
K
V
R
-
D
----------
D
I
L
V
E
--
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
E
V
L
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
-
I
V
Y
R
D
L
K
P
E
N
I
L
---
L
D
E
---
I
---
G
H
---
I
K
L
T
D
F
G
----
L
---
S
-
K
E
--
S
-
V
-
D
--
Q
E
--
K
-
K
AY--
S
-
F
----
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
H
S
-
Q
-
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
N
E
-
T
M
N
M
I
L
K
---
A
K
L
-
G
M
P
----
Q
----
F
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
GSE--
G
V
E
E
------
I
K
R
H
LFFANI
D
-----------
W
D
K
L
Y
K
-----
R
E
V
Q
P
P
-------
379
Blastp_CBE
54.79
34%
6
- C1 -
-
6G77
7.0
-
KS6A6_HUMAN
B:
[31-304]
-----------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
---
K
TGP
D
-
A
G
Q
-
L
Y
A
M
K
V
L
K
K
A
S
L
-
K
V
R
-
D
----------
D
I
L
V
E
--
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
E
V
L
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
-
I
V
Y
R
D
L
K
P
E
N
I
L
---
L
D
E
---
I
---
G
H
---
I
K
L
T
D
F
G
----
L
---
S
-
K
E
--
S
-
V
-
D
--
Q
E
--
K
-
K
AY--
S
-
F
----
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
H
S
-
Q
-
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
N
E
-
T
M
N
M
I
L
K
---
A
K
L
-
G
M
P
----
Q
----
F
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
GSE--
G
V
E
E
------
I
K
R
H
LFFANI
D
-----------
W
D
K
L
Y
K
-----
R
E
V
Q
P
P
-------
508
Blastp_CBE
54.67
32%
-36
- C1 -
-
3OWP
5.9
-
KAPCA_HUMAN
A:
[41-297]
-----------------------------------------------------------------------------
L
---
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
K
---
E
-
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
-
K
L
K
Q
I
E
-
H
-
T
L
N
E
K
R
I
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
----
F
---
A
-
K
R
--
V
-
K
-
G
------
R
-
T
----
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
-
I
Y
E
K
I
V
S
---
G
K
V
-
R
F
P
----
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
------
I
K
N
H
------
K
-----------
W
-----------------------
356
Blastp_CBE
54.42
35%
-2
- C1 -
-
3A61
7.8
-
KS6B1_HUMAN
A:
[19-296]
-----------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
---
N
-
T
G
K
-
I
F
A
M
K
V
L
-------------------
K
A
E
R
N
I
L
E
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
I
-
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
---
L
N
H
---
Q
---
G
H
---
V
K
L
T
D
F
G
----------------------------------------
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
H
N
-
R
-
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
-
T
I
D
K
I
L
K
---
C
K
L
-
N
L
P
----
P
----
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
GAGPG
D
A
G
E
------
V
Q
A
H
------
P
FFRHIN-----
W
E
E
L
L
A
-----
R
K
V
E
P
P
-------
505
Blastp_CBE
54.40
32%
-35
- C1 -
-
3POO
3.3
-
KAPCA_HUMAN
A:
[41-301]
-----------------------------------------------------------------------------
L
---
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
K
---
E
-
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
-
K
L
K
Q
I
E
-
H
-
T
L
N
E
K
R
I
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
----
F
---
A
-
K
R
--
V
-
K
-
G
------
R
-
T
----
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
-
I
Y
E
K
I
V
S
---
G
K
V
-
R
F
P
----
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
------
I
K
N
H
------
K
-----------
W
-----------------------
504
Blastp_CBE
54.31
32%
-36
- C1 -
-
4UJ1
5.5
-
KAPCA_HUMAN
A:
[41-297]
-----------------------------------------------------------------------------
L
---
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
K
---
E
-
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
-
K
L
K
Q
I
E
-
H
-
T
L
N
E
K
R
I
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
----
F
---
A
-
K
R
--
V
-
K
-
G
------
R
-
T
----
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
-
I
Y
E
K
I
V
S
---
G
K
V
-
R
F
P
----
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
------
I
K
N
H
------
K
-----------
W
-----------------------
509
Blastp_CBE
54.23
32%
-37
- C1 -
-
3OVV
3.3
-
KAPCA_HUMAN
A:
[41-297]
-----------------------------------------------------------------------------
L
---
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
K
---
E
-
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
-
K
L
K
Q
I
E
-
H
-
T
L
N
E
K
R
I
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
----
F
---
A
-
K
R
--
V
-
K
-
G
------
R
-
T
----
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
-
I
Y
E
K
I
V
S
---
G
K
V
-
R
F
P
----
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
------
I
K
N
H
------
K
-----------
W
-----------------------
503
Blastp_CBE
54.12
32%
-37
- C1 -
-
4UJ2
6.5
-
KAPCA_HUMAN
A:
[41-297]
-----------------------------------------------------------------------------
L
---
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
K
---
E
-
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
-
K
L
K
Q
I
E
-
H
-
T
L
N
E
K
R
I
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
----
F
---
A
-
K
R
--
V
-
K
-
G
------
R
-
T
----
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
-
I
Y
E
K
I
V
S
---
G
K
V
-
R
F
P
----
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
------
I
K
N
H
------
K
-----------
W
-----------------------
460
Blastp_CBE
54.08
32%
-35
- C1 -
-
3L9M
6.8
-
KAPCA_HUMAN
B:
[41-297]
-----------------------------------------------------------------------------
L
---
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
K
---
E
-
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
-
K
L
K
Q
I
E
-
H
-
T
L
N
E
K
R
I
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
D
Q
---
Q
---
G
Y
---
I
K
V
T
D
F
G
----
F
---
A
-
K
R
--
V
-
K
-
G
------
R
-
T
----
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
-
I
Y
E
K
I
V
S
---
G
K
V
-
R
F
P
----
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
------
I
K
N
H
------
K
-----------
W
-----------------------
527
Blastp_CBE
53.98
32%
-31
- C1 -
-
2GNJ
5.3
-
KAPCA_BOVIN
A:
[40-296]
-----------------------------------------------------------------------------
L
---
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
---
E
-
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
-
K
L
K
Q
I
E
-
H
-
T
L
N
E
K
R
I
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
Q
---
Q
---
G
Y
---
I
K
V
A
D
F
G
----
F
---
A
-
K
R
--
V
-
K
-
G
------
R
-
T
----
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
-
I
Y
E
K
I
V
S
---
G
K
V
-
R
F
P
----
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
------
I
K
N
H
------
K
-----------
W
-----------------------
235
Blastp_CBE
53.97
35%
19
- C1 -
-
3MA6
5.9
-
?
B:
[29-295]
------------------------------------------------------------------------------IFS
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
---
K
---
I
-
T
G
Q
-
E
C
A
V
K
V
I
S
K
R
Q
V
-
K
-
Q
--
T
D
K
-
E
-
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
-
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
---
K
---
S
K
DAN
I
R
I
I
D
F
G
----
L
---
S
-
T
H
F-
E
-
A
-
S
--
K
K
--
M
-
K
----
D
-
K
----
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
-
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
---
G
K
Y
-
T
F
E
LPQW
K
----
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
------
A
L
D
H
------
E
-----------
W
I
Q
T
Y
T
------------------
461
Blastp_CBE
53.96
32%
-36
- C1 -
-
3L9M
6.6
-
KAPCA_HUMAN
A:
[41-297]
-----------------------------------------------------------------------------
L
---
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
K
---
E
-
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
-
K
L
K
Q
I
E
-
H
-
T
L
N
E
K
R
I
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
D
Q
---
Q
---
G
Y
---
I
K
V
T
D
F
G
----
F
---
A
-
K
R
--
V
-
K
-
G
------
R
-
T
----
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
-
I
Y
E
K
I
V
S
---
G
K
V
-
R
F
P
----
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
------
I
K
N
H
------
K
-----------
W
-----------------------
526
Blastp_CBE
53.89
32%
-38
- C1 -
-
2GNL
5.4
-
KAPCA_BOVIN
A:
[40-296]
-----------------------------------------------------------------------------
L
---
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
---
E
-
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
-
K
L
K
Q
I
E
-
H
-
T
L
N
E
K
R
I
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
Q
---
Q
---
G
Y
---
I
K
V
A
D
F
G
----
F
---
A
-
K
R
--
V
-
K
-
G
------
R
-
T
----
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
-
I
Y
E
K
I
V
S
---
G
K
V
-
R
F
P
----
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
------
I
K
N
H
------
K
-----------
W
-----------------------
507
Blastp_CBE
53.53
32%
-36
- C1 -
-
3OXT
5.9
-
KAPCA_HUMAN
A:
[41-297]
-----------------------------------------------------------------------------
L
---
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
K
---
E
-
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
-
K
L
K
Q
I
E
-
H
-
T
L
N
E
K
R
I
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
----
F
---
A
-
K
R
--
V
-
K
-
G
------
R
-
T
----
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
-
I
Y
E
K
I
V
S
---
G
K
V
-
R
F
P
----
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
------
I
K
N
H
------
K
-----------
W
-----------------------
511
Blastp_CBE
53.37
32%
-37
- C1 -
-
3L9L
7.4
-
KAPCA_HUMAN
B:
[41-297]
-----------------------------------------------------------------------------
L
---
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
K
---
E
-
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
-
K
L
K
Q
I
E
-
H
-
T
L
N
E
K
R
I
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
----
F
---
A
-
K
R
--
V
-
K
-
G
------
R
-
T
----
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
-
I
Y
E
K
I
V
S
---
G
K
V
-
R
F
P
----
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
------
I
K
N
H
------
K
-----------
W
-----------------------
358
Blastp_CBE
53.23
35%
0
- C1 -
-
3A60
8.3
-
KS6B1_HUMAN
A:
[19-296]
-----------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
---
N
-
T
G
K
-
I
F
A
M
K
V
L
K
K
A
M
---------------
K
A
E
R
N
I
L
E
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
I
-
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
---
L
N
H
---
Q
---
G
H
---
V
K
L
T
D
F
G
----
L
CKE---------------------------------
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
H
N
-
R
-
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
-
T
I
D
K
I
L
K
---
C
K
L
-
N
L
P
----
P
----
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
GAGPG
D
A
G
E
------
V
Q
A
H
------
P
FFRHIN-----
W
E
E
L
L
A
-----
R
K
V
E
P
P
-------
459
Blastp_CBE
52.83
32%
-38
- C1 -
-
3L9N
5.7
-
KAPCA_HUMAN
A:
[41-300]
-----------------------------------------------------------------------------
L
---
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
K
---
E
-
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
-
K
L
K
Q
I
E
-
H
-
T
L
N
E
K
R
I
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
D
Q
---
Q
---
G
Y
---
I
K
V
T
D
F
G
----
F
---
A
-
K
R
--
V
-
K
-
G
------
R
-
T
----
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
-
I
Y
E
K
I
V
S
---
G
K
V
-
R
F
P
----
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
------
I
K
N
H
------
K
-----------
W
-----------------------
491
Blastp_CBE
52.76
32%
-29
- C1 -
-
6C0U
3.4
-
KAPCA_HUMAN
A:
[44-300]
-----------------------------------------------------------------------------
L
---
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
K
---
E
-
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
-
K
L
K
Q
I
E
-
H
-
T
L
N
E
K
R
I
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
----
F
---
A
-
K
R
--
V
-
K
-
G
------
R
-
T
----
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
-
I
Y
E
K
I
V
S
---
G
K
V
-
R
F
P
----
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
------
I
K
N
H
------
K
-----------
W
-----------------------
530
Blastp_CBE
52.41
32%
-32
- C1 -
-
3MVJ
4.9
-
KAPCA_HUMAN
A:
[61-317]
-----------------------------------------------------------------------------
L
---
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
K
---
E
-
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
-
K
L
K
Q
I
E
-
H
-
T
L
N
E
K
R
I
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
----
F
---
A
-
K
R
--
V
-
K
-
G
------
R
-
T
----
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
-
I
Y
E
K
I
V
S
---
G
K
V
-
R
F
P
----
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
------
I
K
N
H
------
K
-----------
W
-----------------------
385
Blastp_CBE
51.33
34%
4
- C1 -
-
6G78
7.4
-
KS6A6_HUMAN
A:
[31-304]
-----------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
---
K
TGP
D
-
A
G
Q
-
L
Y
A
M
K
V
L
K
K
A
S
L
-
K
V
R
-
D
----------
D
I
L
V
E
--
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
E
V
L
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
-
I
V
Y
R
D
L
K
P
E
N
I
L
---
L
D
E
---
I
---
G
H
---
I
K
L
T
D
F
G
----
L
---
S
-
K
E
--
S
-
V
-
D
--
Q
------------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
H
S
-
Q
-
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
N
E
-
T
M
N
M
I
L
K
---
A
K
L
-
G
M
P
----
Q
----
F
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
GSE--
G
V
E
E
------
I
K
R
H
LFFANI
D
-----------
W
D
K
L
Y
K
-----
R
E
V
Q
P
P
-------
360
Blastp_CBE
50.64
35%
-4
- C1 -
-
4RLO
9.0
-
KS6B1_HUMAN
B:
[7-284]
-----------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
---
N
-
T
G
K
-
I
F
A
M
K
V
L
K
K
---------------------------
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
I
-
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
---
L
N
H
---
Q
---
G
H
---
V
K
L
T
D
F
G
----
L
CKE
S
-
I
------------------------------
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
H
N
-
R
-
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
-
T
I
D
K
I
L
K
---
C
K
L
-
N
L
P
----
P
----
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
GAGPG
D
A
G
E
------
V
Q
A
H
------
P
FFRHIN-----
W
E
E
L
L
A
-----
R
K
V
E
P
P
-------
357
Blastp_CBE
50.59
35%
-3
- C1 -
-
3A60
9.1
-
KS6B1_HUMAN
B:
[19-296]
-----------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
---
N
-
T
G
K
-
I
F
A
M
K
V
L
K
K
---------------------------
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
I
-
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
---
L
N
H
---
Q
---
G
H
---
V
K
L
T
D
F
G
----
L
CKE
S
------------------------------
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
H
N
-
R
-
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
-
T
I
D
K
I
L
K
---
C
K
L
-
N
L
P
----
P
----
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
GAGPG
D
A
G
E
------
V
Q
A
H
------
P
FFRHIN-----
W
E
E
L
L
A
-----
R
K
V
E
P
P
-------
404
Blastp_CBE
50.46
33%
-5
- C1 -
-
3G51
6.3
-
KS6A3_MOUSE
A:
[26-301]
-----------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
---
D
-
A
R
Q
-
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V------------
R
D
I
L
V
E
--
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
---
L
D
E
---
E
---
G
H
---
I
K
L
T
D
F
G
----
L
---
S
-
K
E
--
S
-
I
------------------------
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
H
T
-
Q
-
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
E
-
T
M
T
M
I
L
K
---
A
K
L
-
G
M
P
----
Q
----
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
GAGPD
G
V
E
E
------
I
K
R
H
------
S
FFSTID-----
W
N
K
L
Y
R
-----
R
E
I
H
P
P
-------
381
Blastp_CBE
49.92
34%
-3
- C1 -
-
6G76
4.6
-
KS6A6_HUMAN
B:
[31-304]
-----------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
---
K
TGP
D
-
A
G
Q
-
L
Y
A
M
K
V
L
K
K
A
S
L
-
K
V------------
R
D
I
L
V
E
--
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
--
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
E
V
L
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
-
I
V
Y
R
D
L
K
P
E
N
I
L
---
L
D
E
---
I
---
G
H
---
I
K
L
T
D
F
G
----
L
---
S
-
K
E
--
S
-
V
-
D
-----------------------
V
E
Y
M
A
P
E
V
V
N
R
R
G
H
S
-
Q
-
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
N
E
-
T
-----------
L
-
G
M
P
----
Q
----
F
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
GSE--
G
V
E
E
------
I
K
R
H
LFFANI
D
-----------
W
D
K
L
Y
K
-----
R
E
V
Q
P
P
-------
418
Blastp_CBE
49.53
34%
-6
- C1 -
-
2W4O
4.3
-
KCC4_HUMAN
A:
[43-313]
--------------------------------------------------------------------IDGS
N
R
D
A
L
S
---
D
F
F
E
V
E
S
E
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
---
K
---
G
-
T
Q
K
-
P
Y
A
L
K
V
L
-
K
K
-------------------
I
G
V
L
L
R
L
S
H
P
N
I
I
K
L
K
E
I
F
E
T
P
T
E
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
K
G
Y
-
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
-
N
G
-
I
V
H
R
D
L
K
P
E
N
L
L
---
Y
A
T
PAP
D
---
A
P
---
L
K
I
A
D
F
-----------------------------------------
G
T
P
G
Y
C
A
P
E
I
L
R
G
C
A
Y
G
-
P
-
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
D
E
R
G
D
Q
F
M
F
R
R
I
L
N
---
C
E
Y
-
Y
F
I
----
S
PWWD
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
-----
T
T
F
Q
------
A
L
Q
H
------
P
-----------
W
V
T
G
K
A
------------------
384
Blastp_CBE
49.40
34%
0
- C1 -
-
6G78
6.0
-
KS6A6_HUMAN
B:
[31-304]
-----------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
---
K
TGP
D
-
A
G
Q
-
L
Y
A
M
K
V
L
K
K
A
S
L
-
K
V
R
-
D
----------
D
I
L
V
E
--
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
E
V
L
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
-
I
V
Y
R
D
L
K
P
E
N
I
L
---
L
D
E
---
I
---
G
H
---
I
K
L
T
D
F
G
----
L
---
S
-
K
E
--
S
-
V
-----------------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
H
S
-
Q
-
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
N
E
-
T
M
N
M
I
L
K
---
A
K
L
-
G
M
P
----
Q
----
F
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
GSE--
G
V
E
E
------
I
K
R
H
LFFANI
D
-----------
W
D
K
L
Y
K
-----
R
E
V
Q
P
P
-------
538
Blastp_CBE
49.25
33%
-34
- C1 -
-
3NX8
3.5
-
KAPCA_HUMAN
A:
[41-280]
-----------------------------------------------------------------------------
L
---
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
K
---
E
-
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
-
K
L
K
Q
I
E
-
H
-
T
L
N
E
K
R
I
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
----
F
---
A
-
K
R
--
V
-
K
-
G
------
R
-
T
----
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
-
I
Y
E
K
I
V
S
---
G
K
V
-
R
F
P
----
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
-------------------------------------------------------------
102
Blastp_CBE
48.17
73%
-112
- C1 -
-
2NP8
7.4
-
AURKA_HUMAN
A:
[8-166]
--------------------------------------------------------------------------
Q
W
A
L
---
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
---
K
---
Q
-
S
K
F
-
I
L
A
L
K
V
L
F
K
A
Q
L
-
E
-
K
-
A
G
V
E
-
H
-
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
----
W
---
S
-
V
H
--
A
-
P
-
S
--
S
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
401
Blastp_CBE
47.59
33%
18
- C1 -
-
4EL9
7.4
-
KS6A3_MOUSE
A:
[27-302]
-----------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
---
D
-
A
R
Q
-
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
-
D
R
V
-------
R
D
I
L
V
E
--
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
---
L
D
E
---
E
---
G
H
---
I
K
L
T
D
F
G
----
L
---
S
-
K
E
--
S
-------
E
--
K
-
K
AY--
S
-
F
----
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
H
T
-
Q
-
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
E
-
T
M
T
M
I
L
K
---
A
K
L
-
G
M
P
----
Q
----
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
GAGPD
G
V
E
E
------
I
K
R
H
------
S
FFSTID-----
W
N
K
L
Y
R
-----
R
E
I
H
P
P
-------
382
Blastp_CBE
47.55
34%
6
- C1 -
-
6G76
6.1
-
KS6A6_HUMAN
A:
[31-304]
-----------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
---
K
TGP
D
-
A
G
Q
-
L
Y
A
M
K
V
L
K
K
A
S
L
-
K
V
R
-
D
----------
D
I
L
V
E
--
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
E
V
L
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
-
I
V
Y
R
D
L
K
P
E
N
I
L
---
L
D
E
---
I
---
G
H
---
I
K
L
T
D
F
G
----
L
---
S
-
K
E
--
S
-
V
-
D
--
Q
E
--
K
-
K
----
A
Y
F
----
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
H
S
-
Q
-
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
N
E
-
T
M
N
M
I
L
K
---
A
K
L
-
G
M
P
----
Q
----
F
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
GSE--
G
V
E
E
------
I
K
R
H
LFFANI
D
-----------
W
D
K
L
Y
K
-----
R
E
V
Q
P
P
-------
415
Blastp_CBE
46.17
36%
-11
- C1 -
-
2Z7S
6.3
-
KS6A1_HUMAN
A:
[30-273]
-----------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
---
V
TRP
D
-
S
G
H
-
L
Y
A
M
K
V
L
K
-----------------------
I
L
A
D
V
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
---
L
D
E
---
E
---
G
H
---
I
K
L
T
D
F
G
----
L
---
S
-
K
E
----------------------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
Q
G
H
S
-
H
-
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
Q
G
K
D
R
K
E
-
T
M
T
L
I
L
K
---
A
K
L
-
G
M
P
----
Q
----
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
-------------------------------------------------------------
402
Blastp_CBE
45.95
33%
17
- C1 -
-
3UBD
6.1
-
KS6A3_MOUSE
A:
[26-301]
-----------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
---
D
-
A
R
Q
-
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
-
D
R
V
--------
D
I
L
V
E
--
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
---
L
D
E
---
E
---
G
H
---
I
K
L
T
D
F
G
----
L
---
S
-
K
-----------
E
--
K
-
K
AY--
S
-
F
----
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
H
T
-
Q
-
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
E
-
T
M
T
M
I
L
K
---
A
K
L
-
G
M
P
----
Q
----
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
GAGPD
G
V
E
E
------
I
K
R
H
------
S
FFSTID-----
W
N
K
L
Y
R
-----
R
E
I
H
P
P
-------
400
Blastp_CBE
45.44
33%
16
- C1 -
-
4GUE
7.9
-
KS6A3_MOUSE
A:
[27-302]
-----------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
---
D
-
A
R
Q
-
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
-
D
R
V
----------
L
V
E
--
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
---
L
D
E
---
E
---
G
H
---
I
K
L
T
D
F
G
----
L
---
S
-
K
-----------
E
--
K
-
K
AY--
S
-
F
----
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
H
T
-
Q
-
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
E
-
T
M
T
M
I
L
K
---
A
K
L
-
G
M
P
----
Q
----
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
GAGPD
G
V
E
E
------
I
K
R
H
------
S
FFSTID-----
W
N
K
L
Y
R
-----
R
E
I
H
P
P
-------
417
Blastp_CBE
45.23
36%
-14
- C1 -
-
2Z7Q
4.8
-
KS6A1_HUMAN
A:
[30-273]
-----------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
---
V
TRP
D
-
S
G
H
-
L
Y
A
M
K
V
L
------------------------
I
L
A
D
V
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
---
L
D
E
---
E
---
G
H
---
I
K
L
T
D
F
G
----
L
---
S
-
K
E
----------------------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
Q
G
H
S
-
H
-
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
Q
G
K
D
R
K
E
-
T
M
T
L
I
L
K
---
A
K
L
-
G
M
P
----
Q
----
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
-------------------------------------------------------------
416
Blastp_CBE
44.89
36%
-3
- C1 -
-
2Z7R
7.8
-
KS6A1_HUMAN
A:
[30-273]
-----------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
---
V
TRP
D
-
S
G
H
-
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
-----
V
-----------
I
L
A
D
V
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
---
L
D
E
---
E
---
G
H
---
I
K
L
T
D
F
G
----
L
---
S
-
K
E
----------------------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
Q
G
H
S
-
H
-
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
Q
G
K
D
R
K
E
-
T
M
T
L
I
L
K
---
A
K
L
-
G
M
P
----
Q
----
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
-------------------------------------------------------------