@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Screening
Virtual Screening Score
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : BLK_HUMAN: (2020-09-05 )
MGLVSSKKPDKEKPIKEKDKGQWSPLKVSAQDKDAPPLPPLVVFNHLTPPPPDEHLDEDKHFVVALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLVTGREGYVPSNFVARVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELIKHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPWAQDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLYAVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEERPTFEFLQSVLEDFYTATERQYELQP
Atome Classification :
(508 SA)
.........10........20........30........40........50........60........70........80.......--.-90.-........100.......110.......120.......130.......140.......150.......160.....-.-.170.......180.......190.......200.......210.......220....----.----.-------.230---------------------.----------------...-------------------.....240-------.-..---------.....250.......260.---.----......270....--.---...---280.......290.......300..-.-.-.--..310.......320.......330.......340.......350.......360.......370.......380..-.-.-...-.-390-.-.....-...400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(pKd)
(pKd)
(Uniprot)
MGLVSSKKPDKEKPIKEKDKGQWS
P
L
K
V
SAQDKDAPPLP
P
L
V
VFNHLTPPPPDEHLDEDK
H
F
V
V
A
L
Y
D
Y
TAMNDR
D
L
Q
MLKGE
K
L
Q
V
L
--K-G-T-
G
D
W
W
L
A
R
S
LVTGREGYV
P
S
N
F
V
A
R
V
E
S
L
E
M
E
R
W
F
F
R
SQG
R
K
E
A
E
R
Q
L
L
A
P
INKA
G
S
F
L
I
R
ESETNK
G
A
F
S
L
S
V
K
DV-T-T
Q
G
E
L
I
K
H
Y
K
I
R
C
LDEG
G
Y
Y
I
SPRIT
F
P
S
L
Q
A
L
V
Q
H
Y
SKKGD
G
L
C
Q
RLTLPCVRPAPQ----N----P-------WA-----------------------Q----------------
D
E
W-------------------EI
P
R
Q
S
L
--------
R
-
L
V
---------
R
K
LGSGQ
F
G
E
V
W
M
G
Y
YK-N---N----
M
K
V
A
I
K
T
L
-
K
EGT--M---
S
P
E
---
A
FL
G
E
A
N
V
M
K
A
L
Q
H
E
R
L
V
R
L
Y
A
V
VT-K-E-P--
I
Y
I
V
T
E
Y
M
A
R
G
C
L
L
D
F
L
KTDEGSRLSL
P
R
L
I
D
M
S
A
Q
I
A
E
G
M
A
Y
I
E
R
M
N
S
I
H
R
D
L
R
A
A
N
I
L
V
S
E
A
L
C
C
K
I
A
D
F
G
L
-
A
R
-
I
-I-DSE-Y-T---A-QEGAK-F
P
I
K
WTAPE
A
I
H
F
G
V
F
T
I
K
A
D
V
W
S
F
G
V
L
L
M
E
V
V
TYGRVPYPGMS
N
P
E
V
I
R
N
L
E
R
GYRMPRPDTC
P
P
E
L
Y
R
G
V
I
A
E
C
W
RSRPEER
P
T
F
E
F
L
Q
S
V
L
E
D
F
Y
T
A
T
E
R
Q
YELQP
1
PsiBlast_PDB
84.52
69%
-13
- C3 -
-
1QCF
6.4
-
HCK_HUMAN
A:
[10-454]
-------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
-
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
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R
Q
L
L
A
P
G
N
M
L
G
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F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
-
D
P
R
Q
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K
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K
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G
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Y
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T
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S
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L
Q
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D
H
Y
K
K
G
N
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G
L
C
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K
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S
V
P
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M
S
S
K
P
Q
----
K
----
P
-------
W
E
-----------------------
K
----------------
D
A
W
-------------------
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I
P
R
E
S
L
--------
K
-
L
E
---------
K
K
L
G
A
G
Q
F
G
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V
W
M
A
T
Y
N
-
K
---
H
----
T
K
V
A
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T
M
-
K
P
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S
--
M
---
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---
A
F
L
A
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A
N
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T
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Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
--
I
Y
I
I
T
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F
M
A
K
G
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L
L
D
F
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K
S
D
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G
S
K
Q
P
L
P
K
L
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Q
I
A
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G
M
A
F
I
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Q
R
N
Y
I
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R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
-
A
R
-
V
-
I
E
D
N
E
-
Y
-
T
---
A
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R
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G
A
K
-
F
P
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K
W
T
A
P
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A
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N
F
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K
S
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W
S
F
G
I
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L
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I
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Y
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P
Y
P
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S
N
P
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A
L
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R
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Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
-
N
I
M
M
R
C
W
K
N
R
P
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E
R
P
T
F
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Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
33
Blastp_CBE
83.74
69%
-28
- C3 -
-
3VRY
8.7
-
HCK_HUMAN
B:
[10-453]
-------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
-
G
E
W
W
K
A
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S
L
A
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K
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G
Y
I
P
S
N
Y
V
A
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S
L
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T
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W
F
F
K
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K
D
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L
L
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N
M
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G
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D
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T
T
K
G
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Y
S
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S
V
R
D
Y
-
D
P
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K
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F
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L
V
D
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Y
K
K
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N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
E
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
---------
K
K
L
G
A
G
Q
F
G
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W
M
A
T
Y
N
-
K
---
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----
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K
V
A
V
K
T
M
-
K
P
G
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--
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---
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V
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---
A
F
L
A
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A
N
V
M
K
T
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Q
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D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
--
I
Y
I
I
T
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F
M
A
K
G
S
L
L
D
F
L
K
S
D
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G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
-
A
R
-
V
-
I
-------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
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W
S
F
G
I
L
L
M
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V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
-
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
--
17
PsiBlast_PDB
83.70
69%
-11
- C3 -
-
5H09
9.5
-
HCK_HUMAN
A:
[10-454]
-------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
-
G
E
W
W
K
A
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S
L
A
T
R
K
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G
Y
I
P
S
N
Y
V
A
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D
S
L
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F
F
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G
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K
D
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L
L
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D
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T
T
K
G
S
Y
S
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S
V
R
D
Y
-
D
P
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Q
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N
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P
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F
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T
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Q
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L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
E
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
---------
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-
K
---
H
----
T
K
V
A
V
K
T
M
-
K
P
G
S
--
M
---
S
V
E
---
A
F
L
A
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A
N
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K
L
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A
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F
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Q
P
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K
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F
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A
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M
A
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I
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Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
-
A
R
-
V
-
I
E
D
N
E
-
Y
-
T
---
A
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R
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A
K
-
F
P
I
K
W
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A
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A
I
N
F
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I
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Y
P
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S
N
P
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I
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A
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G
Y
R
M
P
R
P
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N
C
P
E
E
L
Y
-
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
20
PsiBlast_PDB
83.52
69%
-12
- C3 -
-
5H0H
10.3
-
HCK_HUMAN
A:
[10-454]
-------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
-
G
E
W
W
K
A
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S
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A
T
R
K
E
G
Y
I
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S
N
Y
V
A
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V
D
S
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E
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W
F
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I
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R
K
D
A
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L
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N
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F
M
I
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D
S
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T
T
K
G
S
Y
S
L
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D
Y
-
D
P
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D
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G
L
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V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
E
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
---------
K
K
L
G
A
G
Q
F
G
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V
W
M
A
T
Y
N
-
K
---
H
----
T
K
V
A
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S
--
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---
A
F
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A
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A
N
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K
L
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A
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V
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--
I
Y
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F
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L
L
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D
F
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M
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I
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Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
-
A
R
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V
-
I
E
D
N
E
-
Y
-
T
---
A
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R
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A
K
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F
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I
K
W
T
A
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A
I
N
F
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I
K
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W
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L
L
M
E
I
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R
I
P
Y
P
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M
S
N
P
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I
R
A
L
E
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G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
-
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
10
PsiBlast_PDB
83.32
69%
-23
- C3 -
-
3VS3
9.2
-
HCK_HUMAN
A:
[10-454]
-------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
-
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
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K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
-
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
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L
V
D
H
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K
K
G
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D
G
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C
Q
K
L
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V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
E
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
---------
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-
K
---
H
----
T
K
V
A
V
K
T
M
-
K
P
G
S
--
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
-
A
R
-
V
-
I
-------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
-
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
526
HHSearch
83.22
69%
-12
- C3 -
-
5H0B
9.7
-
HCK_HUMAN
A:
[8-454]
-----------------------------------------------------------
R
I
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
-
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
-
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
E
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
---------
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-
K
---
H
----
T
K
V
A
V
K
T
M
-
K
P
G
S
--
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
--
I
Y
I
I
T
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F
M
A
K
G
S
L
L
D
F
L
K
S
D
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G
S
K
Q
P
L
P
K
L
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S
A
Q
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A
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M
A
F
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R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
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F
G
L
-
A
R
-
V
-
I
-
E
D
N
E
Y
-
T
---
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
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N
F
G
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F
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S
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V
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S
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G
I
L
L
M
E
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V
T
Y
G
R
I
P
Y
P
G
M
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N
P
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I
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A
L
E
R
G
Y
R
M
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R
P
E
N
C
P
E
E
L
Y
-
N
I
M
M
R
C
W
K
N
R
P
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P
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F
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Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
18
PsiBlast_PDB
82.85
69%
-11
- C3 -
-
5H0E
10.0
-
HCK_HUMAN
A:
[10-454]
-------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
-
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
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R
K
D
A
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R
Q
L
L
A
P
G
N
M
L
G
S
F
M
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D
S
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T
T
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G
S
Y
S
L
S
V
R
D
Y
-
D
P
R
Q
G
D
T
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K
H
Y
K
I
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L
D
N
G
G
F
Y
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S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
E
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
---------
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-
K
---
H
----
T
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A
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-
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P
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S
--
M
---
S
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---
A
F
L
A
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A
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V
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L
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H
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K
L
V
K
L
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A
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V
T
-
K
-
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-
P
--
I
Y
I
I
T
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F
M
A
K
G
S
L
L
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S
D
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K
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P
L
P
K
L
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A
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M
A
F
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R
N
Y
I
H
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D
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R
A
A
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I
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A
S
L
V
C
K
I
A
D
F
G
L
-
A
R
-
V
-
I
E
D
N
E
-
Y
-
T
---
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
-
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
21
Blastp_CBE
82.77
69%
-12
- C3 -
-
5H0B
9.7
-
HCK_HUMAN
A:
[10-453]
-------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
-
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
-
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
E
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
---------
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-
K
---
H
----
T
K
V
A
V
K
T
M
-
K
P
G
S
--
M
---
S
V
E
---
A
F
L
A
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A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
-
A
R
-
V
-
I
E
D
N
E
-
Y
-
T
---
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
-
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
--
524
HHSearch
82.46
62%
-4
- C3 -
-
2H8H
8.0
-
SRC_HUMAN
A:
[87-531]
-------------------------------------------------------------
T
F
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
--
N
-
N
T
E
-
G
D
W
W
L
A
H
S
L
S
T
G
Q
T
G
Y
I
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S
N
Y
V
A
P
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D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
N
A
E
N
P
R
G
T
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
S
D
F
-
D
N
A
K
G
L
N
V
K
H
Y
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I
R
K
L
D
S
G
G
F
Y
I
T
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R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
T
S
K
P
Q
T---
Q
----
G
-------
L
A
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
-
I
-
E
D
N
E
Y
-
T
---
A
-
R
Q
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
--
525
HHSearch
82.39
69%
-21
- C3 -
-
2HCK
5.5
-
HCK_HUMAN
B:
[2-438]
-----------------------------------------------------------
D
I
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
-
G
E
W
W
K
A
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S
L
A
T
R
K
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G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
-
D
P
R
Q
G
D
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K
H
Y
K
I
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T
L
D
N
G
G
F
Y
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S
P
R
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T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
E
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
---------
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-
K
---
H
----
T
K
V
A
V
K
T
M
-
K
P
G
S
--
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
-
A
R
-
V
-
G
-
A
---------------
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
-
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
Q
Q
Q
P
27
Blastp_CBE
82.36
69%
-24
- C3 -
-
3VS4
8.7
-
HCK_HUMAN
B:
[10-453]
-------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
-
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
-
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
E
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
---------
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-
K
---
H
----
T
K
V
A
V
K
T
M
-
K
P
G
S
--
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
-
A
R
-
V
-
I
-------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
-
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
--
19
PsiBlast_PDB
82.35
69%
-10
- C3 -
-
5H0G
9.6
-
HCK_HUMAN
A:
[10-454]
-------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
-
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
-
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
E
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
---------
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-
K
---
H
----
T
K
V
A
V
K
T
M
-
K
P
G
S
--
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
-
A
R
-
V
-
I
E
D
N
E
-
Y
-
T
---
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
-
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
31
Blastp_CBE
82.28
69%
-21
- C3 -
-
3VS0
8.1
-
HCK_HUMAN
B:
[10-453]
-------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
-
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
-
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
E
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
---------
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-
K
---
H
----
T
K
V
A
V
K
T
M
-
K
P
G
S
--
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
-
A
R
-
V
-
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
-
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
--
13
PsiBlast_PDB
82.23
69%
-20
- C3 -
-
3VS6
8.3
-
HCK_HUMAN
A:
[10-454]
-------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
-
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
-
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
E
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
---------
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-
K
---
H
----
T
K
V
A
V
K
T
M
-
K
P
G
S
--
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
-
A
R
-
V
-
I
-------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
-
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
25
Blastp_CBE
82.13
69%
-18
- C3 -
-
3VS6
8.1
-
HCK_HUMAN
B:
[10-453]
-------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
-
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
-
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
E
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
---------
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-
K
---
H
----
T
K
V
A
V
K
T
M
-
K
P
G
S
--
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
-
A
R
-
V
-
I
-------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
-
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
--
2
PsiBlast_PDB
82.08
69%
-19
- C3 -
-
2C0I
11.6
-
HCK_HUMAN
A:
[10-454]
-------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
-
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
-
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
E
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
---------
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-
K
---
H
----
T
K
V
A
V
K
T
M
-
K
P
G
S
--
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
-
A
R
-
V
-
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
-
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
29
Blastp_CBE
81.66
69%
-19
- C3 -
-
3VS2
8.0
-
HCK_HUMAN
B:
[10-453]
-------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
-
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
-
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
E
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
---------
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-
K
---
H
----
T
K
V
A
V
K
T
M
-
K
P
G
S
--
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
-
A
R
-
V
-
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
-
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
--
36
Blastp_CBE
81.62
69%
-17
- C3 -
-
2C0I
10.9
-
HCK_HUMAN
B:
[10-453]
-------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
-
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
-
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
E
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
---------
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-
K
---
H
----
T
K
V
A
V
K
T
M
-
K
P
G
S
--
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
-
A
R
-
V
-
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
-
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
--
3
PsiBlast_PDB
81.56
69%
-17
- C3 -
-
2C0O
10.3
-
HCK_HUMAN
A:
[10-454]
-------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
-
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
-
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
E
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
---------
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-
K
---
H
----
T
K
V
A
V
K
T
M
-
K
P
G
S
--
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
-
A
R
-
V
-
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
-
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
6
PsiBlast_PDB
81.52
69%
-15
- C3 -
-
3VRZ
9.3
-
HCK_HUMAN
A:
[10-454]
-------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
-
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
-
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
E
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
---------
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-
K
---
H
----
T
K
V
A
V
K
T
M
-
K
P
G
S
--
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
-
A
R
-
V
-
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
-
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
9
PsiBlast_PDB
81.50
69%
-18
- C3 -
-
3VS2
9.0
-
HCK_HUMAN
A:
[10-454]
-------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
-
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
-
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
---
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
E
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
---------
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-
K
---
H
----
T
K
V
A
V
K
T
M
-
K
P
G
S
--
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
-
A
R
-
V
-
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
-
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
5
PsiBlast_PDB
81.48
69%
-17
- C3 -
-
3VRY
8.7
-
HCK_HUMAN
A:
[10-454]
-------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
-
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
-
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
------
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
E
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
---------
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-
K
---
H
----
T
K
V
A
V
K
T
M
-
K
P
G
S
--
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
-
A
R
-
V
-
I
-------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
-
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
12
PsiBlast_PDB
81.45
69%
-19
- C3 -
-
3VS5
7.9
-
HCK_HUMAN
A:
[10-454]
-------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
-
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
-
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
E
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
---------
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-
K
---
H
----
T
K
V
A
V
K
T
M
-
K
P
G
S
--
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
-
A
R
-
V
-
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
-
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
34
Blastp_CBE
81.42
69%
-21
- C3 -
-
2C0T
10.2
-
HCK_HUMAN
B:
[10-453]
-------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
-
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
-
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
E
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
---------
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-
K
---
H
----
T
K
V
A
V
K
T
M
-
K
P
G
S
--
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
-
A
R
-
V
-
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
-
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
--
37
Blastp_CBE
81.26
68%
-22
- C3 -
-
2HCK
5.5
-
HCK_HUMAN
B:
[4-433]
-------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
-
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
-
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
E
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
---------
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-
K
---
H
----
T
K
V
A
V
K
T
M
-
K
P
G
S
--
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
-
A
R
-
V
-----------------
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
-
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
-----
4
PsiBlast_PDB
81.20
69%
-14
- C3 -
-
2C0T
11.4
-
HCK_HUMAN
A:
[10-454]
-------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
-
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
-
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
------
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
E
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
---------
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-
K
---
H
----
T
K
V
A
V
K
T
M
-
K
P
G
S
--
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
-
A
R
-
V
-
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
-
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
28
Blastp_CBE
81.12
69%
-13
- C3 -
-
3VS3
9.3
-
HCK_HUMAN
B:
[10-453]
-------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
-
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
-
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
-----
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
E
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
---------
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-
K
---
H
----
T
K
V
A
V
K
T
M
-
K
P
G
S
--
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
-
A
R
-
V
-
I
E----------------
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
-
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
--
44
Blastp_CBE
80.99
63%
-3
- C3 -
-
2H8H
8.0
-
SRC_HUMAN
A:
[89-528]
---------------------------------------------------------------
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
--
N
-
N
-
T
E
G
D
W
W
L
A
H
S
L
S
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
N
A
E
N
P
R
G
T
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
S
D
F
D
N
-
A
K
G
L
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
T
S
K
P
Q
----
T
----
Q
G------
L
A
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
-
I
E
D
N
E
-
Y
-
T
---
A
-
R
Q
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
-----
14
PsiBlast_PDB
80.96
69%
-17
- C3 -
-
3VS7
6.7
-
HCK_HUMAN
A:
[10-454]
-------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
-
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
-
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
E
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
---------
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-
K
---
H
----
T
K
V
A
V
K
T
M
-
K
P
G
S
--
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
-
A
R
-
V
----------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
-
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
35
Blastp_CBE
80.93
69%
-21
- C3 -
-
2C0O
9.9
-
HCK_HUMAN
B:
[10-453]
-------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
-
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
-
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
E
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
---------
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-
K
---
H
----
T
K
V
A
V
K
T
M
-
K
P
G
S
--
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
-
A
R
-
V
-
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
-
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
--
32
Blastp_CBE
80.84
69%
-21
- C3 -
-
3VRZ
9.5
-
HCK_HUMAN
B:
[10-453]
-------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
-
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
-
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
E
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
---------
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-
K
---
H
----
T
K
V
A
V
K
T
M
-
K
P
G
S
--
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
-
A
R
-
V
-
I
-------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
-
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
--
30
Blastp_CBE
80.80
69%
-17
- C3 -
-
3VS1
9.2
-
HCK_HUMAN
B:
[10-453]
-------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
-
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
-
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
E
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
---------
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-
K
---
H
----
T
K
V
A
V
K
T
M
-
K
P
G
S
--
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
-
A
R
-
V
-
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
-
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
--
40
Blastp_CBE
80.74
68%
-21
- C3 -
-
1AD5
4.5
-
HCK_HUMAN
A:
[4-433]
-------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
-
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
-
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
E
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
---------
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-
K
---
H
----
T
K
V
A
V
K
T
M
-
K
P
G
S
--
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
-
A
R
-
V
-----------------
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
-
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
-----
7
PsiBlast_PDB
80.64
69%
-16
- C3 -
-
3VS0
8.8
-
HCK_HUMAN
A:
[10-454]
-------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
-
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
-
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
-----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
E
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
---------
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-
K
---
H
----
T
K
V
A
V
K
T
M
-
K
P
G
S
--
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
-
A
R
-
V
-
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
-
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
16
PsiBlast_PDB
80.58
69%
-18
- C3 -
-
4LUE
9.6
-
HCK_HUMAN
A:
[10-453]
-------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
-
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
-
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
E
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
---------
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-
K
---
H
----
T
K
V
A
V
K
T
M
-
K
P
G
S
--------------
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
-
A
R
-
V
-
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
-
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
-
15
PsiBlast_PDB
80.58
69%
-20
- C3 -
-
4LUD
3.8
-
HCK_HUMAN
A:
[10-454]
-------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
-
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
---
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
-
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
--
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
E
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
---------
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-
K
---
H
----
T
K
V
A
V
K
T
M
-
K
P
--------
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
-
A
R
-
V
-
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
----
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
-
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
42
Blastp_CBE
80.46
63%
-6
- C3 -
-
6F3F
5.5
-
SRC_MOUSE
A:
[9-448]
---------------------------------------------------------------
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
--
N
-
N
-
T
E
G
D
W
W
L
A
H
S
L
S
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
N
A
E
N
P
R
G
T
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
S
D
F
D
N
-
A
K
G
L
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
T
S
K
P
Q
----
T
----
Q
G------
L
A
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
G
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
-
I
E
D
N
E
-
Y
-
T
---
A
-
R
Q
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
-----
39
Blastp_CBE
80.43
68%
-21
- C3 -
-
1AD5
4.6
-
HCK_HUMAN
B:
[4-433]
-------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
-
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
-
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
E
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
---------
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-
K
---
H
----
T
K
V
A
V
K
T
M
-
K
P
G
S
--
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
-
A
R
-
V
-----------------
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
-
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
-----
8
PsiBlast_PDB
80.36
69%
-13
- C3 -
-
3VS1
8.7
-
HCK_HUMAN
A:
[10-454]
-------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
-
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
-
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
---------
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
E
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
---------
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-
K
---
H
----
T
K
V
A
V
K
T
M
-
K
P
G
S
--
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
-
A
R
-
V
-
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
-
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
38
Blastp_CBE
80.27
68%
-19
- C3 -
-
2HCK
5.6
-
HCK_HUMAN
A:
[4-433]
-------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
-
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
-
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
E
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
---------
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-
K
---
H
----
T
K
V
A
V
K
T
M
-
K
P
G
S
--
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
-
A
R
-
V
-----------------
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
-
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
-----
528
HHSearch
80.24
62%
-9
- C3 -
-
1Y57
7.3
-
SRC_HUMAN
A:
[3-449]
------------------------------------------------------------
T
T
F
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
--
N
-
N
T
E
-
G
D
W
W
L
A
H
S
L
S
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
N
A
E
N
P
R
G
T
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
S
D
F
-
D
N
A
K
G
L
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
T
S
K
P
Q
T---
Q
----
G
-------
L
A
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
-
I
-
E
D
N
E
Y
-
T
---
A
-
R
Q
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
-
43
Blastp_CBE
80.21
63%
-4
- C3 -
-
2SRC
5.8
-
SRC_HUMAN
A:
[6-445]
---------------------------------------------------------------
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
--
N
-
N
-
T
E
G
D
W
W
L
A
H
S
L
S
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
N
A
E
N
P
R
G
T
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
S
D
F
D
N
-
A
K
G
L
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
T
S
K
P
Q
----
T
----
Q
G------
L
A
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
-
I
E
D
N
E
-
Y
-
T
---
A
-
R
Q
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
-----
11
PsiBlast_PDB
80.20
69%
-10
- C3 -
-
3VS4
8.4
-
HCK_HUMAN
A:
[10-454]
-------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
-
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
-
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
------
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
E
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
---------
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-
K
---
H
----
T
K
V
A
V
K
T
M
-
K
P
G
S
--
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
-
A
R
-
V
-
I
E------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
-
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
45
Blastp_CBE
80.16
63%
-2
- C3 -
-
4K11
6.0
-
SRC_HUMAN
A:
[4-443]
---------------------------------------------------------------
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
--
N
-
N
-
T
E
G
D
W
W
L
A
H
S
L
S
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
N
A
E
N
P
R
G
T
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
S
D
F
D
N
-
A
K
G
L
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
T
S
K
P
Q
----
T
----
Q
G------
L
A
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
-
I
E
D
N
E
-
Y
-
T
---
A
-
R
Q
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
-----
24
Blastp_CBE
79.89
69%
-18
- C3 -
-
3VS7
6.9
-
HCK_HUMAN
B:
[10-453]
-------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
-
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
-
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
-----
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
E
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
---------
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-
K
---
H
----
T
K
V
A
V
K
T
M
-
K
P
G
S
--
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
-
A
R
------------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
-
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
--
41
Blastp_CBE
79.77
63%
-7
- C3 -
-
1Y57
7.3
-
SRC_HUMAN
A:
[6-447]
---------------------------------------------------------------
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
--
N
-
N
-
T
E
G
D
W
W
L
A
H
S
L
S
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
N
A
E
N
P
R
G
T
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
S
D
F
D
N
-
A
K
G
L
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
T
S
K
P
Q
----
T
----
Q
G------
L
A
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
-
I
E
D
N
E
-
Y
-
T
---
A
-
R
Q
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
26
Blastp_CBE
79.69
69%
-14
- C3 -
-
3VS5
8.7
-
HCK_HUMAN
B:
[10-453]
-------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
-
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
-
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
------
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
E
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
---------
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-
K
---
H
----
T
K
V
A
V
K
T
M
-
K
P
G
S
--
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
-
A
R
-
V
-
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
-
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
--
22
Blastp_CBE
79.55
69%
-21
- C3 -
-
4LUE
9.7
-
HCK_HUMAN
B:
[10-453]
-------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
-
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
-
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
E
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
---------
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-
K
---
H
----
T
K
V
A
V
K
T
M
-
K
P
----------------
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
-
A
R
-
V
-
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
---
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
-
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
--
46
Blastp_CBE
79.23
63%
-4
- C3 -
-
1KSW
5.7
-
SRC_HUMAN
A:
[6-445]
---------------------------------------------------------------
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
--
N
-
N
-
T
E
G
D
W
W
L
A
H
S
L
S
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
N
A
E
N
P
R
G
T
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
S
D
F
D
N
-
A
K
G
L
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
T
S
K
P
Q
----
T
----
Q
G------
L
A
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
-
I
E
D
N
E
-
Y
-
T
---
A
-
R
Q
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
-----
23
Blastp_CBE
75.94
69%
-16
- C3 -
-
4LUD
5.5
-
HCK_HUMAN
B:
[10-452]
-------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
-
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
---
S
Y
S
L
S
V
R
D
Y
-
D
P
R
Q
G
D
T
V
K
H
Y
K
I
-----------------
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
E
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
---------
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-
K
---
H
----
T
K
V
A
V
K
T
M
-
K
P
G
-------
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
-
A
R
-
V
-
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
-
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
--
230
Blastp_CBE
74.36
43%
-3
- C3 -
-
2FO0
10.0
-
ABL1_HUMAN
A:
[37-474]
--------------------------------------------------------
E
N
D
P
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
GY
N
-
H
-
N
-
G
E
W
C
E
A
Q
T
--
K
N
G
Q
G
W
V
P
S
N
Y
I
T
P
V
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
S
G
I
N
--
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
-----
Y
E
G
R
-
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
--
P
K
R
N
----
K
----
P
-------
T
V
-----------------------
Y
GVSPNY----------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
532
HHSearch
73.88
42%
-6
- C3 -
-
2FO0
10.0
-
ABL1_HUMAN
A:
[36-477]
-------------------------------------------------------
S
E
N
D
P
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
--
G
Y
N
-
H
-
N
G
E
W
C
E
A
Q
T
-
K
N
G
Q
G
W
V
P
S
N
Y
I
T
P
V
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
S
--
G
I
N
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
Y
E
------
G
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
K
R
N
K
P
----
T
VYGV
S
-------
P
N
-----------------------
Y
----------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
-
P
--
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
-
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
--------
232
Blastp_CBE
73.74
43%
-5
- C3 -
-
1OPL
10.0
-
ABL1_HUMAN
A:
[81-516]
----------------------------------------------------------
D
P
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
GY
N
-
H
-
N
-
G
E
W
C
E
A
Q
T
--
K
N
G
Q
G
W
V
P
S
N
Y
I
T
P
V
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
S
G
I
N
--
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
-----
Y
E
G
R
-
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
--
P
K
R
N
----
K
----
P
-------
T
V
-----------------------
Y
GVSPNY----------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
229
Blastp_CBE
72.88
43%
6
- C3 -
-
1OPK
10.3
-
ABL1_MOUSE
A:
[44-477]
------------------------------------------------------------
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
GY
N
-
H
-
N
-
G
E
W
C
E
A
Q
T
--
K
N
G
Q
G
W
V
P
S
N
Y
I
T
P
V
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
S
G
I
N
--
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
-----
Y
E
G
R
-
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
K
R
N
K
P
----
T
----
I
-------
Y
G
VSPN-------------------
Y
----------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
534
HHSearch
72.41
42%
-9
- C3 -
-
1OPK
10.3
-
ABL1_MOUSE
A:
[44-479]
------------------------------------------------------------
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
--
G
Y
N
-
H
-
N
G
E
W
C
E
A
Q
T
-
K
N
G
Q
G
W
V
P
S
N
Y
I
T
P
V
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
S
--
G
I
N
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
Y
E
------
G
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
K
R
N
K
P
TIYG
V
----
S
-------
P
N
-----------------------
Y
----------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
-
P
--
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
-
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
---------
233
Blastp_CBE
71.16
42%
-4
- C3 -
-
5MO4
12.0
-
ABL1_HUMAN
A:
[44-477]
------------------------------------------------------------
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
GY
N
-
H
-
N
-
G
E
W
C
E
A
Q
T
--
K
N
G
Q
G
W
V
P
S
N
Y
I
T
P
V
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
S
G
I
N
--
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
-----
Y
E
G
R
-
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
--
P
K
R
N
----
K
----
P
-------
T
V
-----------------------
Y
GVSPNY----------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
-------
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
----------------------------
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
531
HHSearch
69.49
42%
-0
- C3 -
-
5MO4
12.0
-
ABL1_HUMAN
A:
[44-480]
------------------------------------------------------------
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
--
G
Y
N
-
H
-
N
G
E
W
C
E
A
Q
T
-
K
N
G
Q
G
W
V
P
S
N
Y
I
T
P
V
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
S
--
G
I
N
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
Y
E
------
G
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
K
R
N
K
P
----
T
VYGV
S
-------
P
N
-----------------------
Y
----------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
-------
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
-
P
--
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
----------------------------
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
-
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
--------
231
Blastp_CBE
67.65
43%
-46
- C3 -
-
1OPL
9.3
-
ABL1_HUMAN
B:
[140-516]
--------------------------------------------------------------------------------------------------------------------------
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
S
G
I
N
--
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
-----
Y
E
G
R
-
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
--
P
--------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
138
Blastp_CBE
67.65
69%
-144
- C3 -
-
5XP7
4.6
-
SRC_CHICK
A:
[10-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
-
I
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
172
Blastp_CBE
67.40
69%
-143
- C3 -
-
3EN4
6.6
-
SRC_CHICK
B:
[10-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
------------------
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
145
Blastp_CBE
67.09
69%
-146
- C3 -
-
4YBK
9.1
-
SRC_CHICK
A:
[9-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
-------------------
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
180
Blastp_CBE
67.07
69%
-139
- C3 -
-
2OIQ
10.5
-
SRC_CHICK
A:
[9-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
----------------------
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
208
Blastp_CBE
66.95
68%
-136
- C3 -
-
3GEQ
6.4
-
SRC_CHICK
A:
[9-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
A
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
150
Blastp_CBE
66.90
69%
-146
- C3 -
-
4O2P
8.0
-
SRC_CHICK
B:
[9-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
-
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
-
I
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
79
Blastp_CBE
66.90
72%
-103
- C3 -
-
2OF2
7.2
-
LCK_HUMAN
A:
[2-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-------
W
W
-----------------------
E
----------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
---------
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-
G
---
H
----
T
K
V
A
V
K
S
L
-
K
Q
G
S
--
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
-
A
R
-
L
-
I
E
D
N
E
-
Y
-
T
---
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
-
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
--------
74
Blastp_CBE
66.76
72%
-144
- C3 -
-
3BYU
11.0
-
LCK_HUMAN
A:
[7-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
P
-------
W
W
-----------------------
E
----------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
---------
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-
G
---
H
----
T
K
V
A
V
K
S
L
-
K
Q
G
S
--
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
------------------------
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
-
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
--------
161
Blastp_CBE
66.74
69%
-144
- C3 -
-
3UQF
6.9
-
SRC_CHICK
A:
[11-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
-------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
75
Blastp_CBE
66.63
72%
-142
- C3 -
-
3BYS
11.2
-
LCK_HUMAN
A:
[6-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
----
K
----
P
-------
W
W
-----------------------
E
----------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
---------
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-
G
---
H
----
T
K
V
A
V
K
S
L
-
K
Q
G
S
--
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
---------------------------
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
-
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
--------
135
Blastp_CBE
66.59
69%
-144
- C3 -
-
4MXO
7.4
-
SRC_HUMAN
B:
[11-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
-
I
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
141
Blastp_CBE
66.56
69%
-147
- C3 -
-
5K9I
7.1
-
SRC_CHICK
B:
[12-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
97
Blastp_CBE
66.53
69%
-148
- C3 -
-
3TZ7
9.6
-
SRC_CHICK
B:
[10-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
---------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
163
Blastp_CBE
66.51
69%
-136
- C3 -
-
3G6G
12.1
-
SRC_CHICK
A:
[9-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-----------------------
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
105
Blastp_CBE
66.47
69%
-146
- C3 -
-
3F3T
6.9
-
SRC_CHICK
A:
[10-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
155
Blastp_CBE
66.44
69%
-139
- C3 -
-
4DGG
8.9
-
SRC_CHICK
A:
[9-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
---------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
206
Blastp_CBE
66.37
68%
-141
- C3 -
-
5SWH
6.6
-
SRC_CHICK
A:
[11-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
C
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
----------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
193
Blastp_CBE
66.35
68%
-147
- C3 -
-
3QLG
8.2
-
SRC_CHICK
B:
[9-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
------
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
162
Blastp_CBE
66.35
69%
-140
- C3 -
-
3G6G
12.9
-
SRC_CHICK
B:
[9-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
------------------------
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
124
Blastp_CBE
66.35
69%
-146
- C3 -
-
3F3W
10.9
-
SRC_CHICK
B:
[11-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
170
Blastp_CBE
66.33
69%
-146
- C3 -
-
3EN5
6.5
-
SRC_CHICK
B:
[9-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
---------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
94
Blastp_CBE
66.30
69%
-147
- C3 -
-
3TZ9
10.0
-
SRC_CHICK
A:
[10-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
207
Blastp_CBE
66.20
68%
-137
- C3 -
-
3GEQ
6.4
-
SRC_CHICK
B:
[9-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
A
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
-
I
--------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
214
Blastp_CBE
66.16
68%
-147
- C3 -
-
3SVV
6.1
-
SRC_CHICK
B:
[9-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
---
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
-
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
C
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
---------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
157
Blastp_CBE
66.16
69%
-139
- C3 -
-
4AGW
9.4
-
SRC_CHICK
A:
[10-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
-----------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
95
Blastp_CBE
66.15
69%
-138
- C3 -
-
3TZ8
11.6
-
SRC_CHICK
B:
[9-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
------------------------
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
212
Blastp_CBE
66.11
68%
-145
- C3 -
-
4MXY
7.1
-
SRC_HUMAN
B:
[11-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
L
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
-
I
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
210
Blastp_CBE
66.11
68%
-145
- C3 -
-
4MXZ
7.1
-
SRC_HUMAN
B:
[11-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
L
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
-
I
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
144
Blastp_CBE
66.07
69%
-143
- C3 -
-
5J5S
9.5
-
SRC_CHICK
A:
[11-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
----------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
89
Blastp_CBE
66.06
72%
-151
- C3 -
-
2OG8
10.8
-
LCK_HUMAN
A:
[2-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
---------
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-
G
---
H
----
T
K
V
A
V
K
S
L
-
K
Q
G
S
--
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
---------------------------
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
-
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
----------
159
Blastp_CBE
66.01
69%
-139
- C3 -
-
3UQG
3.8
-
SRC_CHICK
A:
[11-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
-
I
--------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
78
Blastp_CBE
66.01
72%
-103
- C3 -
-
2OF4
6.4
-
LCK_HUMAN
A:
[2-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-------
W
W
-----------------------
E
----------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
---------
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-
G
---
H
----
T
K
V
A
V
K
S
L
-
K
Q
G
S
--
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
-
A
R
-
L
-
I
E
D
N
E
-
Y
-
T
---
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
-
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
--------
96
Blastp_CBE
66.00
69%
-144
- C3 -
-
3TZ8
10.8
-
SRC_CHICK
A:
[10-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
173
Blastp_CBE
65.98
69%
-143
- C3 -
-
3EN4
6.5
-
SRC_CHICK
A:
[11-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
----
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
---------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
48
Blastp_CBE
65.97
75%
-102
- C3 -
-
5ZJ6
9.2
-
HCK_HUMAN
A:
[14-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
P
-------
W
E
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
---------
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-
K
---
H
----
T
K
V
A
V
K
T
M
-
K
P
G
S
--
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
-
A
R
-
V
-
I
E
D
N
E
-
Y
-
T
---
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
-
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
--------
166
Blastp_CBE
65.92
69%
-141
- C3 -
-
3F6X
7.0
-
SRC_CHICK
B:
[9-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
-
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
-
I
-----------------
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
194
Blastp_CBE
65.91
68%
-140
- C3 -
-
3QLG
8.2
-
SRC_CHICK
A:
[11-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
---------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
47
Blastp_CBE
65.90
75%
-103
- C3 -
-
5ZJ6
8.9
-
HCK_HUMAN
B:
[15-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-------
W
E
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
---------
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-
K
---
H
----
T
K
V
A
V
K
T
M
-
K
P
G
S
--
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
-
A
R
-
V
-
I
E
D
N
E
-
Y
-
T
---
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
-
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
--------
125
Blastp_CBE
65.86
69%
-143
- C3 -
-
3F3W
10.5
-
SRC_CHICK
A:
[10-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
147
Blastp_CBE
65.81
69%
-143
- C3 -
-
4YBJ
9.9
-
SRC_CHICK
A:
[12-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
----------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
99
Blastp_CBE
65.79
69%
-152
- C3 -
-
3G5D
7.6
-
SRC_CHICK
B:
[11-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
---
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
-----
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
205
Blastp_CBE
65.78
68%
-139
- C3 -
-
5SWH
6.3
-
SRC_CHICK
B:
[9-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
C
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
----------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
129
Blastp_CBE
65.77
69%
-140
- C3 -
-
1YOL
6.2
-
SRC_HUMAN
B:
[9-278]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
G
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
------------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
535
HHSearch
65.72
43%
-53
- C3 -
-
4XEY
8.1
-
ABL1_HUMAN
B:
[7-385]
---------------------------------------------------------------------------------------------------------------------------
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
S
--
G
I
N
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
Y
E
------
G
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
---
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
K
----------------------------------------------
Y
----------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
------
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
----
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
-
P
--
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
-
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
--------
130
Blastp_CBE
65.66
69%
-139
- C3 -
-
1YOL
4.0
-
SRC_HUMAN
A:
[6-278]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
G
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
------------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
154
Blastp_CBE
65.63
69%
-143
- C3 -
-
4DGG
9.9
-
SRC_CHICK
B:
[9-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
--------------
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
160
Blastp_CBE
65.62
69%
-145
- C3 -
-
3UQF
7.6
-
SRC_CHICK
B:
[9-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
-------------
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
----------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
143
Blastp_CBE
65.59
69%
-143
- C3 -
-
5J5S
8.6
-
SRC_CHICK
B:
[9-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
--
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
----------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
88
Blastp_CBE
65.56
72%
-144
- C3 -
-
2OG8
10.2
-
?
B:
[1-265]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
---------
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-
G
---
H
----
T
K
V
A
V
K
S
L
-
K
Q
G
S
--
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
-
A
-------------------------
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
-
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
---------
215
Blastp_CBE
65.54
68%
-140
- C3 -
-
3SVV
5.6
-
SRC_CHICK
A:
[10-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
-
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
C
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
111
Blastp_CBE
65.55
69%
-157
- C3 -
-
2HWO
4.4
-
SRC_CHICK
A:
[9-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
-
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
---------------
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
----------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
117
Blastp_CBE
65.54
69%
-152
- C3 -
-
5D12
5.6
-
SRC_CHICK
A:
[10-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-----------
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
-
I
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
102
Blastp_CBE
65.50
69%
-139
- C3 -
-
3F3V
10.4
-
SRC_CHICK
A:
[10-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
104
Blastp_CBE
65.44
69%
-137
- C3 -
-
3F3U
6.0
-
SRC_CHICK
A:
[10-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
198
Blastp_CBE
65.40
68%
-139
- C3 -
-
3OEZ
9.8
-
SRC_CHICK
A:
[10-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
204
Blastp_CBE
65.38
68%
-139
- C3 -
-
5SYS
10.0
-
SRC_CHICK
A:
[11-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
C
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
----------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
156
Blastp_CBE
65.38
69%
-139
- C3 -
-
4AGW
10.1
-
SRC_CHICK
B:
[11-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
-----------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
101
Blastp_CBE
65.37
69%
-141
- C3 -
-
3F3V
10.5
-
SRC_CHICK
B:
[9-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
178
Blastp_CBE
65.34
69%
-141
- C3 -
-
3D7T
8.3
-
SRC_CHICK
B:
[11-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
-
I
-----------------
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
98
Blastp_CBE
65.29
69%
-140
- C3 -
-
3TZ7
9.3
-
SRC_CHICK
A:
[10-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
---------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
197
Blastp_CBE
65.28
68%
-139
- C3 -
-
3OEZ
8.9
-
SRC_CHICK
B:
[9-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
---------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
203
Blastp_CBE
65.19
68%
-139
- C3 -
-
5SYS
10.3
-
SRC_CHICK
B:
[11-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
C
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
----------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
100
Blastp_CBE
65.15
69%
-150
- C3 -
-
3G5D
8.2
-
SRC_CHICK
A:
[10-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
---
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-----------
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
237
Blastp_CBE
65.13
43%
-45
- C3 -
-
4XEY
8.1
-
ABL1_HUMAN
B:
[7-382]
---------------------------------------------------------------------------------------------------------------------------
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
S
G
I
N
--
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
-----
Y
E
G
R
-
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
---
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
--
P
K
---------------------------------------------Y---------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
------
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
----
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
68
Blastp_CBE
65.09
72%
-109
- C3 -
-
3B2W
10.8
-
LCK_HUMAN
A:
[13-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
---------
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-
G
---
H
----
T
K
V
A
V
K
S
L
-
K
Q
G
S
--
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
-
A
R
-
L
-
I
E
D
N
E
-
Y
-
T
---
A
---
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
-
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
---------
209
Blastp_CBE
65.04
68%
-137
- C3 -
-
3G6H
11.6
-
SRC_CHICK
B:
[11-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
I
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
---------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
142
Blastp_CBE
65.04
69%
-143
- C3 -
-
5K9I
6.5
-
SRC_CHICK
A:
[12-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
---------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
158
Blastp_CBE
65.02
69%
-143
- C3 -
-
3UQG
4.2
-
SRC_CHICK
B:
[9-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
----
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
---------
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
-
I
--------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
183
Blastp_CBE
65.01
69%
-142
- C3 -
-
1YOM
7.0
-
SRC_HUMAN
B:
[6-278]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
G
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
----------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
118
Blastp_CBE
65.00
69%
-154
- C3 -
-
5D11
5.0
-
SRC_CHICK
B:
[10-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
------------------
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
195
Blastp_CBE
64.97
68%
-143
- C3 -
-
3QLF
4.7
-
SRC_CHICK
B:
[11-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
----
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
-------------------------
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
146
Blastp_CBE
64.96
69%
-147
- C3 -
-
4YBJ
5.2
-
SRC_CHICK
B:
[12-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
------
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
---------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
181
Blastp_CBE
64.90
68%
-142
- C3 -
-
4MXX
7.7
-
SRC_HUMAN
B:
[11-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
T
D
F
G
L
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
184
Blastp_CBE
64.86
69%
-134
- C3 -
-
1YOM
6.8
-
SRC_HUMAN
A:
[6-278]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
G
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
-----------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
67
Blastp_CBE
64.81
75%
-96
- C3 -
-
2HK5
9.3
-
HCK_HUMAN
A:
[2-269]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
----
K
----
P
-------
W
E
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
---------
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-
K
---
H
----
T
K
V
A
V
K
T
M
-
K
P
G
S
--
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
-
A
R
-
V
-
I
E
D
N
E
-
Y
-
T
---
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
-
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
------------
200
Blastp_CBE
64.77
68%
-141
- C3 -
-
5TEH
4.7
-
SRC_CHICK
A:
[9-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
C
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
---------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
216
Blastp_CBE
64.76
68%
-142
- C3 -
-
4MCV
5.5
-
SRC_CHICK
B:
[2-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
-
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
-
I
-----------------
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
103
Blastp_CBE
64.71
69%
-136
- C3 -
-
3F3U
6.3
-
SRC_CHICK
B:
[10-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
-------
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
218
Blastp_CBE
64.67
69%
-139
- C3 -
-
3U51
8.4
-
SRC_CHICK
B:
[3-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
----------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
70
Blastp_CBE
64.67
72%
-144
- C3 -
-
2OFV
10.3
-
LCK_HUMAN
A:
[6-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
P
-------
W
W
-----------------------
E
----------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
---------
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-
G
---
H
----
T
K
V
A
V
K
S
L
-
K
Q
G
---------------
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
-
A
--------------------------
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
-
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
-----------
201
Blastp_CBE
64.63
68%
-142
- C3 -
-
5T0P
6.4
-
SRC_CHICK
B:
[11-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
C
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
-
I
--------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
219
Blastp_CBE
64.54
69%
-139
- C3 -
-
3U51
8.7
-
SRC_CHICK
A:
[3-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
---------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
119
Blastp_CBE
64.40
69%
-151
- C3 -
-
5D11
5.5
-
SRC_CHICK
A:
[11-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
---------
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
174
Blastp_CBE
64.27
69%
-136
- C3 -
-
3EL8
8.1
-
SRC_CHICK
A:
[11-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
49
Blastp_CBE
64.22
72%
-96
- C3 -
-
2PL0
10.2
-
LCK_HUMAN
A:
[11-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
P
-------
W
W
-----------------------
E
----------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
---------
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-
G
---
H
----
T
K
V
A
V
K
S
L
-
K
Q
G
S
--
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
-
A
R
-
L
-
I
E
D
N
E
-
Y
-
T
---
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
-
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
-----------
220
Blastp_CBE
64.18
69%
-95
- C3 -
-
3U4W
10.5
-
SRC_CHICK
A:
[2-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
-
I
E
D
N
E
-
Y
-
T
---
A
-
R
Q
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
113
Blastp_CBE
64.09
69%
-151
- C3 -
-
6HVF
6.2
-
?
A:
[10-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
-------------------
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
-----------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
202
Blastp_CBE
64.04
68%
-143
- C3 -
-
5T0P
6.7
-
SRC_CHICK
A:
[10-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
C
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
-
I
--------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
114
Blastp_CBE
63.96
69%
-153
- C3 -
-
6HVE
4.9
-
?
B:
[11-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
-------------------
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
-----------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
168
Blastp_CBE
63.94
69%
-152
- C3 -
-
3EN7
5.6
-
SRC_CHICK
A:
[9-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
---
G
E
V
W
M
G
T
W
N
----------
T
R
V
A
I
K
T
L
-
K
P
---------------
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
-----------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
93
Blastp_CBE
63.92
69%
-137
- C3 -
-
3TZ9
9.4
-
SRC_CHICK
B:
[10-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
----------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
109
Blastp_CBE
63.88
69%
-156
- C3 -
-
2HWP
3.2
-
SRC_CHICK
A:
[9-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
------------
V
K
L
G
Q
G
C
-
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
-------------------
F
L
Q
-
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
---
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
----------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
120
Blastp_CBE
63.84
69%
-158
- C3 -
-
5D10
6.4
-
SRC_CHICK
B:
[10-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
----------------------
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
---------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
509
Blastp_CBE
63.78
37%
-56
- C3 -
-
6JMF
6.5
-
A:
[8-370]
---------------------------------------------------------------------------------------------------------------------------
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
E
L
L
V
----
H
S
G
D
F
L
V
R
E
S
Q
-
G
K
Q
E
Y
V
L
S
V
------
L
W
D
G
L
P
R
H
F
I
I
Q
S
L
D
N
--
L
Y
R
L
E
G
E
G
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
P
L
T
K
K
S
G
V
V
L
H
R
A
V
P
K
-----------------------------------------------------------
D
K
W
-------------------
V
L
N
H
E
D
L
--------
V
-
L
G
---------
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
D
---
N
----
T
L
V
A
V
K
S
C
-
R
E
-
T
--
L
---
P
P
D
LKA
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
-
Q
-
P
--
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
-
E
G
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
-
S
R
-
E
E
A
-
D
G
V
-
Y
-
A
---
A
-
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
-
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
------------
153
Blastp_CBE
63.73
69%
-146
- C3 -
-
4FIC
5.3
-
SRC_CHICK
A:
[9-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
---
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
----------------
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
---------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
126
Blastp_CBE
63.72
69%
-155
- C3 -
-
2QQ7
4.7
-
SRC_CHICK
B:
[11-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
---------------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
---------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
199
Blastp_CBE
63.70
68%
-137
- C3 -
-
5TEH
6.5
-
SRC_CHICK
B:
[9-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
C
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
134
Blastp_CBE
63.66
69%
-139
- C3 -
-
6ATE
4.7
-
SRC_HUMAN
A:
[10-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
------------
P
E
---
A
F
--
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
536
HHSearch
63.58
36%
-46
- C3 -
-
3BKB
8.5
-
A:
[8-374]
-------------------------------------------------------------------------------------------------------------------------
K
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
E
L
L
V
----
H
S
G
D
F
L
V
R
E
S
Q
G
-
K
Q
E
Y
V
L
S
V
L
W
D
------
G
L
P
R
H
F
I
I
Q
S
-
L
D
N
-
L
Y
R
L
E
G
E
G
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
P
L
T
K
K
S
G
V
V
L
H
R
-------------
A
-------
V
P
-----------------------
K
----------------
D
K
W
-------------------
V
L
N
H
E
D
L
--------
V
-
L
G
---------
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
D
---
N
----
T
L
V
A
V
K
S
C
-
R
E
T
L
PP
D
---
L
K
A
---
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
-
Q
-
P
--
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
G
-
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
-
S
R
-
E
-
E
-
A
D
G
-
V
Y
A
---
A
S
G
G
L
R
Q
-
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
-
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
----------
91
Blastp_CBE
63.55
72%
-103
- C3 -
-
3MPM
7.2
-
LCK_HUMAN
A:
[4-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
---------
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-
G
---
H
----
T
K
V
A
V
K
S
L
-
K
Q
G
S
--
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
N
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
-
A
R
-
L
-
I
E
D
N
E
-
Y
-
T
---
A
-
R
-----
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
-
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
-----------
107
Blastp_CBE
63.50
69%
-160
- C3 -
-
2QLQ
6.0
-
SRC_CHICK
A:
[9-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
----------------------
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
---
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
-----------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
121
Blastp_CBE
63.49
69%
-144
- C3 -
-
5D10
5.9
-
SRC_CHICK
A:
[11-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
----
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
----
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
------------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
175
Blastp_CBE
63.48
69%
-139
- C3 -
-
3EL7
9.9
-
SRC_CHICK
A:
[10-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
-
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
------
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
----------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
222
Blastp_CBE
63.47
68%
-149
- C3 -
-
4LGH
7.0
-
SRC_CHICK
A:
[1-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
N
-
G
--------
T
R
V
A
I
K
T
L
---------------------
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
-----------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
227
Blastp_CBE
63.40
68%
-143
- C3 -
-
4LGG
6.4
-
SRC_CHICK
B:
[1-265]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
----
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-----
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
-----------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
90
Blastp_CBE
63.35
72%
-105
- C3 -
-
4C3F
7.5
-
LCK_HUMAN
A:
[4-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
---------
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-
G
---
H
----
T
K
V
A
V
K
S
L
-
K
Q
G
S
--
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
N
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
-
A
R
-
L
-
I
E
D
N
E
-
Y
-
T
---
A
-
R
-----
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
-
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
-----------
538
HHSearch
63.17
36%
-55
- C3 -
-
3CBL
8.5
-
A:
[8-374]
-------------------------------------------------------------------------------------------------------------------------
K
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
E
L
L
V
----
H
S
G
D
F
L
V
R
E
S
Q
---
Q
E
Y
V
L
S
V
-----------
P
R
H
F
I
I
-----
N
-
L
Y
R
L
----
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
P
L
-----
V
V
L
H
---------
R
----
A
-------
V
P
-----------------------
K
----------------
D
K
W
-------------------
V
L
N
H
E
D
L
--------
V
-
L
G
---------
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
D
---
N
----
T
L
V
A
V
K
S
C
-
R
E
T
L
PP
D
---
L
K
A
---
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
-
Q
-
P
--
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
G
-
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
-
S
R
-
E
-
E
-
A
D
G
-
V
Y
A
---
A
S
G
G
L
R
Q
-
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
-
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
----------
123
Blastp_CBE
63.13
69%
-156
- C3 -
-
3LOK
1.8
-
SRC_CHICK
A:
[10-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
---
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
---------------------
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
112
Blastp_CBE
63.05
69%
-143
- C3 -
-
6HVF
6.8
-
?
B:
[11-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
------------------
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
------------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
228
Blastp_CBE
62.99
68%
-147
- C3 -
-
4LGG
5.0
-
SRC_CHICK
A:
[1-265]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
---------------
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
----
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
-----------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
149
Blastp_CBE
62.95
69%
-96
- C3 -
-
4U5J
5.9
-
SRC_CHICK
A:
[12-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
-
I
E--------------
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
152
Blastp_CBE
62.94
69%
-147
- C3 -
-
4FIC
5.2
-
SRC_CHICK
B:
[11-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-----------------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
---------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
537
HHSearch
62.84
36%
-48
- C3 -
-
6JMF
6.5
-
A:
[6-372]
-------------------------------------------------------------------------------------------------------------------------
K
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
E
L
L
V
----
H
S
G
D
F
L
V
R
E
S
Q
G
-
K
Q
E
Y
V
L
S
V
L
W
D
------
G
L
P
R
H
F
I
I
Q
S
L
-
D
N
-
L
Y
R
L
E
G
E
G
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
P
L
T
K
K
S
G
V
V
L
H
---------
R
----
A
-------
V
P
-----------------------
K
----------------
D
K
W
-------------------
V
L
N
H
E
D
L
--------
V
-
L
G
---------
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
D
---
N
----
T
L
V
A
V
K
S
C
-
R
E
T
L
PP
D
---
L
K
A
---
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
-
Q
-
P
--
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
G
-
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
-
S
R
-
E
-
E
-
A
D
G
-
V
Y
A
---
A
S
G
G
L
R
Q
-
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
-
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
----------
164
Blastp_CBE
62.79
69%
-97
- C3 -
-
3F6X
7.1
-
SRC_CHICK
D:
[10-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
-
I
E----------------
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
106
Blastp_CBE
62.79
69%
-147
- C3 -
-
2QLQ
2.4
-
SRC_CHICK
B:
[10-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-----------------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
196
Blastp_CBE
62.70
68%
-149
- C3 -
-
3QLF
7.8
-
SRC_CHICK
A:
[11-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
-----------------
L
Q
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
----------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
136
Blastp_CBE
62.69
69%
-95
- C3 -
-
4MXO
7.1
-
SRC_HUMAN
A:
[10-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
-
I
E------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
110
Blastp_CBE
62.66
69%
-146
- C3 -
-
2HWO
3.1
-
SRC_CHICK
B:
[11-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
---------------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
-----------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
171
Blastp_CBE
62.65
69%
-152
- C3 -
-
3EN5
6.2
-
SRC_CHICK
A:
[13-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
-
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-----------------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
-------------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
127
Blastp_CBE
62.62
69%
-152
- C3 -
-
2QQ7
4.8
-
SRC_CHICK
A:
[10-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
-
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
--------------------
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
115
Blastp_CBE
62.62
69%
-99
- C3 -
-
6HVE
5.2
-
?
A:
[9-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
-
I
E------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
221
Blastp_CBE
62.59
68%
-138
- C3 -
-
4LGH
5.5
-
SRC_CHICK
B:
[3-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
-
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
------------------
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
---------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
540
HHSearch
62.57
37%
-22
- C3 -
-
4FL2
5.6
-
KSYK_HUMAN
A:
[162-633]
-------------------------------------------------------------------------------------------------------------------------
T
A
H
E
K
M
P
W
F
H
G
K
I
S
R
E
E
S
E
Q
I
V
L
I
G
S
K
T
N
G
K
F
L
I
R
A
R
D
N
-
N
G
S
Y
A
L
C
L
L
H
E
------
G
K
V
L
H
Y
R
I
D
K
D
K
T
G
K
L
S
I
P
E
G
K
K
F
D
T
L
W
Q
L
V
E
H
Y
S
Y
K
A
D
G
L
L
R
V
L
T
V
P
C
Q
K
I
G
T
--------------------QREALPMDTEVYESPYADPEEIR
P
----------------
K
E
V
-------------------
Y
L
D
R
K
L
L
--------
T
L
E
D
---------
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
Q
-
M
KKV
V
----
K
T
V
A
V
K
I
L
-
K
N
E
A
--
N
DPA
L
K
D
---
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
E
-
A
-
E
-
S
--
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
N
--
R
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
-
S
K
-
A
-
L
-
R
A
D
-
E
-
N
YYK
A
-
Q
T
H
G
K
-
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
-
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
---------
177
Blastp_CBE
62.56
69%
-100
- C3 -
-
3DQX
4.4
-
SRC_CHICK
A:
[12-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
-
I
E--------------
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
116
Blastp_CBE
62.56
69%
-143
- C3 -
-
5D12
6.0
-
SRC_CHICK
B:
[11-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-------------
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
132
Blastp_CBE
62.52
69%
-93
- C3 -
-
2BDF
7.5
-
SRC_HUMAN
B:
[2-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
-
I
E---------------
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
140
Blastp_CBE
62.32
69%
-95
- C3 -
-
5XP5
3.7
-
SRC_CHICK
A:
[12-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
-
I
E--------------
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
167
Blastp_CBE
62.25
69%
-99
- C3 -
-
3F6X
7.6
-
SRC_CHICK
A:
[9-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-----------
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
-
I
E----------------
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
122
Blastp_CBE
62.22
69%
-155
- C3 -
-
3LOK
4.1
-
SRC_CHICK
B:
[11-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
-----------------------
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
---------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
139
Blastp_CBE
62.21
69%
-96
- C3 -
-
5XP5
4.6
-
SRC_CHICK
B:
[12-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
-
I
E--------------
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
165
Blastp_CBE
62.17
69%
-95
- C3 -
-
3F6X
7.4
-
SRC_CHICK
C:
[9-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
---------
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
-
I
E----------------
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
169
Blastp_CBE
62.13
69%
-162
- C3 -
-
3EN6
6.0
-
SRC_CHICK
B:
[10-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
--
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
----------------------
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
--------
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
------------------------------
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
131
Blastp_CBE
62.10
69%
-99
- C3 -
-
2BDJ
9.8
-
SRC_HUMAN
A:
[3-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
-
I
E------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
----------
176
Blastp_CBE
62.05
69%
-94
- C3 -
-
3DQX
4.1
-
SRC_CHICK
B:
[12-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
-
I
E-------------
Q
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
108
Blastp_CBE
62.01
69%
-155
- C3 -
-
2HWP
2.7
-
SRC_CHICK
B:
[11-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
---
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-----------------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
------------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
541
HHSearch
61.77
37%
-48
- C3 -
-
4FL3
5.4
-
KSYK_HUMAN
A:
[161-632]
-------------------------------------------------------------------------------------------------------------------------
T
A
H
E
K
M
P
W
F
H
G
K
I
S
R
E
E
S
E
Q
I
V
L
I
G
S
K
T
N
G
K
F
L
I
R
A
R
D
N
-
N
G
S
Y
A
L
C
L
L
H
E
------
G
K
V
L
H
Y
R
I
D
K
D
K
T
G
K
L
S
I
P
E
G
K
K
F
D
T
L
W
Q
L
V
E
H
Y
S
Y
K
A
D
G
L
L
R
V
L
T
V
P
C
Q
K
------------------------------------------------------------------REALPMDTEVFESPFADPE
E
I
R
P
K
E
V
YLDRKLLT
L
-
E
D
---------
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
Q
-
M
KKV
V
----
K
T
V
A
V
K
I
L
-
K
N
E
A
--
N
DPA
L
K
D
---
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
E
-
A
-
E
-
S
--
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
N
--
R
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
-
S
K
-
A
-
L
-
R
A
-----------------
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
-
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
---------
137
Blastp_CBE
61.76
69%
-92
- C3 -
-
5XP7
6.6
-
SRC_CHICK
B:
[9-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
-
I
E------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
151
Blastp_CBE
61.32
69%
-94
- C3 -
-
4O2P
8.3
-
SRC_CHICK
A:
[10-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
----
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
-
I
E
D
-----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
213
Blastp_CBE
61.04
68%
-97
- C3 -
-
4MXY
6.5
-
SRC_HUMAN
A:
[10-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
L
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
-
I
E------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
211
Blastp_CBE
61.04
68%
-97
- C3 -
-
4MXZ
6.5
-
SRC_HUMAN
A:
[10-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
L
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
-
I
E------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
217
Blastp_CBE
61.00
68%
-95
- C3 -
-
4MCV
5.8
-
SRC_CHICK
A:
[1-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
-
I
E------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
148
Blastp_CBE
60.92
69%
-93
- C3 -
-
4U5J
5.9
-
SRC_CHICK
B:
[12-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
-
I
E--------------
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
133
Blastp_CBE
60.90
69%
-93
- C3 -
-
2BDF
7.1
-
SRC_HUMAN
A:
[3-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
-
I
E------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
77
Blastp_CBE
60.70
71%
-98
- C3 -
-
2OFU
8.1
-
LCK_HUMAN
A:
[1-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
----
K
----
P
-------
W
W
-----------------------
E
----------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
---------
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-
G
---
H
----
T
K
V
A
V
K
S
L
-
K
Q
G
S
--
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
-
A
R
-
L
-
I
-
E
D
N
-
E
-
T
---
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
-
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
--------
539
HHSearch
60.63
34%
-39
- C3 -
-
4K2R
6.5
-
ZAP70_HUMAN
A:
[156-601]
-------------------------------------------------------------------------------------------------------------------------
T
A
H
E
R
M
P
W
Y
H
S
S
L
T
R
E
E
A
E
R
K
L
Y
S
G
A
Q
T
D
G
K
F
L
L
R
P
R
K
-
E
Q
G
T
Y
A
L
S
L
I
Y
G
------
K
T
V
Y
H
Y
L
I
S
Q
D
K
A
G
K
Y
C
I
P
E
G
T
K
F
D
T
L
W
Q
L
V
E
Y
L
K
L
K
A
D
G
L
I
Y
C
L
K
E
A
C
P
N
S
-------------DKPRPMP
M
D
-----------------------
T
SVYESPYSDPEELKDK
K
L
F
-------------------
L
K
R
D
N
L
L
--------
I
-
A
D
---------
I
E
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
R
-
M
RKK
Q
----
I
D
V
A
I
K
V
L
-
K
Q
G
T
--
E
KA-
D
T
E
---
E
M
M
R
E
A
Q
I
M
H
Q
L
D
N
P
Y
I
V
R
L
I
G
V
C
Q
-
A
-
E
-
A
--
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
G
K
R
-
E
E
I
P
V
S
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
N
L
A
A
R
N
V
L
L
V
N
R
H
Y
A
K
I
S
D
F
G
L
-
S
------------------------
W
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
Q
K
P
Y
K
K
M
K
G
P
E
V
M
A
F
I
E
Q
G
K
R
M
E
C
P
P
E
C
P
P
E
L
Y
-
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
Y
S
L
A
-------
66
Blastp_CBE
60.32
70%
-98
- C3 -
-
3KMM
7.8
-
LCK_HUMAN
A:
[10-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
P
-------
W
W
-----------------------
E
----------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
---------
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-
G
---
H
----
T
K
V
A
V
K
S
L
-
K
Q
G
S
--
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
-
A
R
-
L
-
I
-
E
D
N
-
E
-
T
---
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
-
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
E
-------
182
Blastp_CBE
60.17
68%
-92
- C3 -
-
4MXX
7.2
-
SRC_HUMAN
A:
[10-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
T
D
F
G
L
-
A
R
-
L
-
I
E------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
61
Blastp_CBE
60.15
71%
-96
- C3 -
-
2ZYB
7.6
-
LCK_HUMAN
A:
[7-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
P
-------
W
W
-----------------------
E
----------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
---------
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-
G
---
H
----
T
K
V
A
V
K
S
L
-
K
Q
G
S
--
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
-
A
R
-
L
-
I
-
E
D
N
-
E
-
T
---
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
-
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
E
-------
58
Blastp_CBE
60.13
71%
-98
- C3 -
-
3AC3
5.4
-
LCK_HUMAN
A:
[7-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
P
-------
W
W
-----------------------
E
----------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
---------
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-
G
---
H
----
T
K
V
A
V
K
S
L
-
K
Q
G
S
--
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
-
A
R
-
L
-
I
-
E
D
N
-
E
-
T
---
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
-
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
E
-------
52
Blastp_CBE
60.10
71%
-101
- C3 -
-
3AD4
5.0
-
LCK_HUMAN
A:
[7-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
P
-------
W
W
-----------------------
E
----------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
---------
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-
G
---
H
----
T
K
V
A
V
K
S
L
-
K
Q
G
S
--
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
-
A
R
-
L
-
I
-
E
D
N
-
E
-
T
---
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
-
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
E
-------
81
Blastp_CBE
60.06
71%
-96
- C3 -
-
3BYM
8.5
-
LCK_HUMAN
A:
[1-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
----
K
----
P
-------
W
W
-----------------------
E
----------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
---------
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-
G
---
H
----
T
K
V
A
V
K
S
L
-
K
Q
G
S
--
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
-
A
R
-
L
-
I
-
E
D
N
-
E
-
T
---
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
-
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
--------
56
Blastp_CBE
60.04
71%
-99
- C3 -
-
3AC5
7.2
-
LCK_HUMAN
A:
[7-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
P
-------
W
W
-----------------------
E
----------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
---------
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-
G
---
H
----
T
K
V
A
V
K
S
L
-
K
Q
G
S
--
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
-
A
R
-
L
-
I
-
E
D
N
-
E
-
T
---
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
-
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
E
-------
73
Blastp_CBE
60.02
71%
-97
- C3 -
-
1QPC
4.7
-
?
A:
[2-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-------
W
W
-----------------------
E
----------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
---------
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-
G
---
H
----
T
K
V
A
V
K
S
L
-
K
Q
G
S
--
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
-
A
R
-
L
-
I
-
E
D
N
-
E
-
T
---
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
-
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
E
-------
59
Blastp_CBE
59.79
71%
-96
- C3 -
-
3AC2
5.6
-
LCK_HUMAN
A:
[7-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
P
-------
W
W
-----------------------
E
----------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
---------
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-
G
---
H
----
T
K
V
A
V
K
S
L
-
K
Q
G
S
--
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
-
A
R
-
L
-
I
-
E
D
N
-
E
-
T
---
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
-
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
E
-------
83
Blastp_CBE
59.76
71%
-102
- C3 -
-
3BYO
9.4
-
?
A:
[2-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-------
W
W
-----------------------
E
----------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
---------
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-
G
---
H
----
T
K
V
A
V
K
S
L
-
K
Q
G
S
--
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
-
A
R
-
L
-
I
-
E
D
N
-
E
-
T
---
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
-
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
--------
54
Blastp_CBE
59.75
71%
-99
- C3 -
-
3ACJ
5.0
-
LCK_HUMAN
A:
[7-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
P
-------
W
W
-----------------------
E
----------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
---------
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-
G
---
H
----
T
K
V
A
V
K
S
L
-
K
Q
G
S
--
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
-
A
R
-
L
-
I
-
E
D
N
-
E
-
T
---
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
-
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
E
-------
57
Blastp_CBE
59.72
71%
-92
- C3 -
-
3AC4
5.3
-
LCK_HUMAN
A:
[7-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
P
-------
W
W
-----------------------
E
----------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
---------
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-
G
---
H
----
T
K
V
A
V
K
S
L
-
K
Q
G
S
--
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
-
A
R
-
L
-
I
-
E
D
N
-
E
-
T
---
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
-
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
E
-------
69
Blastp_CBE
59.59
72%
-114
- C3 -
-
2OFV
10.5
-
?
B:
[7-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-------
W
W
-----------------------
E
----------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
---------
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-
G
---
H
----
T
K
V
A
V
K
S
L
-
K
Q
G
-------------
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
-
A
R
-
L
-
I
E
D
------------------
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
-------
I
Q
N
L
E
-
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
-
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
----------
65
Blastp_CBE
59.55
71%
-100
- C3 -
-
6PDJ
8.5
-
?
A:
[3-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
----
K
----
P
-------
W
W
-----------------------
E
----------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
---------
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-
G
---
H
----
T
K
V
A
V
K
S
L
-
K
Q
G
S
--
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
-
A
R
-
L
-
I
-
E
D
N
-
E
-
T
---
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
-
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
--------
55
Blastp_CBE
59.53
71%
-98
- C3 -
-
3AC8
6.4
-
LCK_HUMAN
A:
[7-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
P
-------
W
W
-----------------------
E
----------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
---------
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-
G
---
H
----
T
K
V
A
V
K
S
L
-
K
Q
G
S
--
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
-
A
R
-
L
-
I
-
E
D
N
-
E
-
T
---
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
-
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
E
-------
62
Blastp_CBE
59.50
71%
-95
- C3 -
-
2ZM4
7.0
-
LCK_HUMAN
A:
[7-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
P
-------
W
W
-----------------------
E
----------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
---------
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-
G
---
H
----
T
K
V
A
V
K
S
L
-
K
Q
G
S
--
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
-
A
R
-
L
-
I
-
E
D
N
-
E
-
T
---
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
-
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
E
-------
72
Blastp_CBE
59.45
71%
-101
- C3 -
-
1QPE
6.3
-
LCK_HUMAN
A:
[2-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-------
W
W
-----------------------
E
----------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
---------
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-
G
---
H
----
T
K
V
A
V
K
S
L
-
K
Q
G
S
--
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
-
A
R
-
L
-
I
-
E
D
N
-
E
-
T
---
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
-
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
E
-------
80
Blastp_CBE
59.41
70%
-100
- C3 -
-
1QPD
7.1
-
?
A:
[2-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-------
W
W
-----------------------
E
----------------
D
A
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
---------
E
R
L
G
A
G
Q
A
G
E
V
W
M
G
Y
Y
N
-
G
---
H
----
T
K
V
A
V
K
S
L
-
K
Q
G
S
--
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
-
A
R
-
L
-
I
-
E
D
A
-
E
-
T
---
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
-
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
E
-------
63
Blastp_CBE
59.39
71%
-94
- C3 -
-
2ZM1
7.1
-
LCK_HUMAN
A:
[7-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
P
-------
W
W
-----------------------
E
----------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
---------
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-
G
---
H
----
T
K
V
A
V
K
S
L
-
K
Q
G
S
--
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
-
A
R
-
L
-
I
-
E
D
N
-
E
-
T
---
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
-
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
E
-------
60
Blastp_CBE
59.32
71%
-98
- C3 -
-
3AC1
5.4
-
LCK_HUMAN
A:
[7-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
P
-------
W
W
-----------------------
E
----------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
---------
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-
G
---
H
----
T
K
V
A
V
K
S
L
-
K
Q
G
S
--
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
-
A
R
-
L
-
I
-
E
D
N
-
E
-
T
---
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
-
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
E
-------
50
Blastp_CBE
59.24
71%
-90
- C3 -
-
3AD6
4.9
-
LCK_HUMAN
A:
[6-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
----
K
----
P
-------
W
W
-----------------------
E
----------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
---------
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-
G
---
H
----
T
K
V
A
V
K
S
L
-
K
Q
G
S
--
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
-
A
R
-
L
-
I
-
E
D
N
-
E
-
T
---
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
-
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
E
G
------
53
Blastp_CBE
59.22
71%
-94
- C3 -
-
3ACK
5.3
-
LCK_HUMAN
A:
[7-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
P
-------
W
W
-----------------------
E
----------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
---------
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-
G
---
H
----
T
K
V
A
V
K
S
L
-
K
Q
G
S
--
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
-
A
R
-
L
-
I
-
E
D
N
-
E
-
T
---
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
-
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
E
-------
51
Blastp_CBE
59.13
71%
-94
- C3 -
-
3AD5
5.9
-
LCK_HUMAN
A:
[7-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
P
-------
W
W
-----------------------
E
----------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
---------
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-
G
---
H
----
T
K
V
A
V
K
S
L
-
K
Q
G
S
--
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
-
A
R
-
L
-
I
-
E
D
N
-
E
-
T
---
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
-
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
E
-------
71
Blastp_CBE
58.93
71%
-107
- C3 -
-
1QPJ
8.7
-
LCK_HUMAN
A:
[6-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
---------
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-
G
---
H
----
T
K
V
A
V
K
S
L
-
K
Q
G
S
--
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
-
A
R
-
L
-
I
-
E
D
N
-
E
-
T
---
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
-
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
E
-------
87
Blastp_CBE
58.62
72%
-62
- C3 -
-
2ZV8
3.9
-
LYN_MOUSE
A:
[7-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
P
R
E
S
I
--------
K
-
L
V
---------
K
K
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-
N
---
S
----
T
K
V
A
V
K
T
L
-
K
P
G
T
--
M
---
S
V
Q
---
A
F
L
E
E
A
N
L
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
V
V
T
-
K
-
E
E
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
G
K
V
L
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
-
A
R
-
V
-
I
-------------
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
N
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
T
N
A
D
V
M
S
A
L
S
Q
G
Y
R
M
P
R
M
E
N
C
P
D
E
L
Y
-
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
F
Y
-----------
224
Blastp_CBE
58.61
67%
-96
- C3 -
-
3DQW
5.2
-
SRC_CHICK
C:
[11-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
I
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
-
I
-
E
D
N
-
E
-
T
---
A
-
R
Q
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
542
HHSearch
58.43
35%
-37
- C3 -
-
2OZO
6.4
-
ZAP70_HUMAN
A:
[156-601]
-------------------------------------------------------------------------------------------------------------------------
T
A
H
E
R
M
P
W
Y
H
S
S
L
T
R
E
E
A
E
R
K
L
Y
S
G
A
Q
T
D
G
K
F
L
L
R
P
R
K
-
E
Q
G
T
Y
A
L
S
L
I
Y
G
------
K
T
V
Y
H
Y
L
I
S
Q
D
K
A
G
K
Y
C
I
P
E
G
T
K
F
D
T
L
W
Q
L
V
E
Y
L
K
L
K
A
D
G
L
I
Y
C
L
K
E
A
C
P
N
---------------------
M
D
TSVFESPFSDPEELKD-------
K
----------------
K
L
F
-------------------
L
K
R
D
N
L
L
--------
I
-
A
D
---------
I
E
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
R
-
M
RKK
Q
----
I
D
V
A
I
K
V
L
-
K
Q
G
T
--
E
KA-
D
T
E
---
E
M
M
R
E
A
Q
I
M
H
Q
L
D
N
P
Y
I
V
R
L
I
G
V
C
Q
-
A
-
E
-
A
--
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
G
K
R
-
E
E
I
P
V
S
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
N
L
A
A
R
N
V
L
L
V
N
R
H
Y
A
K
I
S
D
F
G
L
-
S
K
-
A
-
L
-
G
------------------
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
Q
K
P
Y
K
K
M
K
G
P
E
V
M
A
F
I
E
Q
G
K
R
M
E
C
P
P
E
C
P
P
E
L
Y
-
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
Y
S
L
A
-------
85
Blastp_CBE
58.40
72%
-45
- C3 -
-
2ZVA
7.8
-
LYN_MOUSE
A:
[7-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
P
R
E
S
I
--------
K
-
L
V
---------
K
K
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-
N
---
S
----
T
K
V
A
V
K
T
L
-
K
P
G
T
--
M
---
S
V
Q
---
A
F
L
E
E
A
N
L
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
V
V
T
-
K
-
E
E
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
G
K
V
L
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
-
A
R
-
V
-
I
E------
T
---
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
N
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
T
N
A
D
V
M
S
A
L
S
Q
G
Y
R
M
P
R
M
E
N
C
P
D
E
L
Y
-
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
F
Y
T
----------
223
Blastp_CBE
58.31
67%
-94
- C3 -
-
3DQW
4.4
-
SRC_CHICK
D:
[10-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
I
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
-
I
-
E
D
N
-
E
-
T
---
A
-
R
Q
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
416
Blastp_CBE
58.20
42%
-167
- C3 -
-
3PJ1
7.9
-
A:
[10-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
---
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-----------
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
----
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
--
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
--------------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
397
Blastp_CBE
58.15
42%
-164
- C3 -
-
6NFI
7.3
-
A:
[4-262]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
----
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
----
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
----
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
-------------------------
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
225
Blastp_CBE
57.94
67%
-95
- C3 -
-
3DQW
4.1
-
SRC_CHICK
B:
[9-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
I
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
-
I
-
E
D
N
-
E
-
T
---
A
-
R
Q
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
226
Blastp_CBE
57.89
67%
-97
- C3 -
-
3DQW
5.0
-
SRC_CHICK
A:
[9-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------
K
----------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
---------
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-
G
---
T
----
T
R
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
I
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-
A
R
-
L
-
I
-
E
D
N
-
E
-
T
---
A
-
R
Q
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
-
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
86
Blastp_CBE
57.89
72%
-61
- C3 -
-
2ZV9
5.7
-
LYN_MOUSE
A:
[7-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
P
R
E
S
I
--------
K
-
L
V
---------
K
K
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-
N
---
S
----
T
K
V
A
V
K
T
L
-
K
P
G
T
--
M
---
S
V
Q
---
A
F
L
E
E
A
N
L
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
V
V
T
-
K
-
E
E
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
G
K
V
L
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
-
A
R
-
V
-
I
--------------
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
N
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
T
N
A
D
V
M
S
A
L
S
Q
G
Y
R
M
P
R
M
E
N
C
P
D
E
L
Y
-
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
F
Y
-----------
84
Blastp_CBE
57.83
72%
-62
- C3 -
-
5XY1
6.2
-
LYN_HUMAN
A:
[7-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
P
R
E
S
I
--------
K
-
L
V
---------
K
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-
N
---
S
----
T
K
V
A
V
K
T
L
-
K
P
G
T
--
M
---
S
V
Q
---
A
F
L
E
E
A
N
L
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
V
V
T
-
R
-
E
E
P
--
I
Y
I
I
T
E
Y
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
G
K
V
L
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
-
A
R
-
V
-------------------
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
D
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
T
N
A
D
V
M
T
A
L
S
Q
G
Y
R
M
P
R
V
E
N
C
P
D
E
L
Y
-
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
F
Y
T
----------
76
Blastp_CBE
57.35
72%
-64
- C3 -
-
3A4O
7.7
-
LYN_HUMAN
X:
[6-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
I
--------
K
-
L
V
---------
K
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-
N
---
S
----
T
K
V
A
V
K
T
L
-
K
P
G
T
--
M
---
S
V
Q
---
A
F
L
E
E
A
N
L
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
V
V
T
-
R
-
E
E
P
--
I
Y
I
I
T
E
Y
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
G
K
V
L
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
-
A
R
-
V
----------------
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
D
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
T
N
A
D
V
M
T
A
L
S
Q
G
Y
R
M
P
R
V
E
N
C
P
D
E
L
Y
-
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
F
Y
T
A
T
E
-------
64
Blastp_CBE
57.35
71%
-94
- C3 -
-
3KXZ
8.4
-
LCK_HUMAN
A:
[16-279]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
---------
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-
G
---
H
----
T
K
V
A
V
K
S
L
-
K
Q
G
S
--
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
-
A
R
-
L
-
I
-
E
D
N
-
E
-
T
---
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
-
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
E
-------
440
Blastp_CBE
56.85
42%
-115
- C3 -
-
6NZM
10.6
-
BTK_HUMAN
A:
[16-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
----
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
544
Fugue
56.35
37%
-40
- C3 -
-
3CD3
8.6
-
A:
[1-376]
-----
S
M
I
P
E
V
Q
K
P
L
H
E
-------------------------------------------------------------------------------------------------------------
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
E
L
L
V
H
S
----
G
D
F
L
V
R
E
S
Q
E
----
Y
V
L
S
V
P
R
------
H
F
I
I
N
L
Y
R
L
---------------
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
P
L
S
G
V
V
L
H
R
A
V
P
K
--------------------------------------------------------------
D
K
W
-------------------
V
L
N
H
E
D
L
--------
V
-
L
G
---------
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
D
---
N
----
T
L
V
A
V
K
S
C
-
R
P
D
L
--
K
---
A
K
-----
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
-
Q
-
P
--
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
-
E
G
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
-
S
R
-
E
-
E
A
D
G
V
-
A
-
A
---
S
-
G
G
L
R
Q
-
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
-
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
H
--------
92
Blastp_CBE
56.02
68%
-90
- C3 -
-
2DQ7
8.6
-
FYN_HUMAN
X:
[1-263]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----------------
D
V
W
-------------------
E
I
P
R
E
S
L
--------
Q
-
L
I
---------
K
R
L
G
N
G
Q
F
G
E
V
W
M
G
T
W
N
-
G
---
N
----
T
K
V
A
I
K
T
L
-
K
P
G
T
--
M
---
S
P
E
---
S
F
L
E
E
A
Q
I
M
K
K
L
K
H
D
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
--
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
D
G
E
G
R
A
L
K
L
P
N
L
V
D
M
A
A
Q
V
A
A
G
M
A
Y
I
E
R
M
N
Y
I
H
R
D
L
R
S
A
N
I
L
V
G
N
G
L
I
C
K
I
A
D
F
G
L
-
A
R
-
L
-
I
-
E
D
N
-
E
-
T
---
A
-
R
Q
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
V
T
K
G
R
V
P
Y
P
G
M
N
N
R
E
V
L
E
Q
V
E
R
G
Y
R
M
P
C
P
Q
D
C
P
I
S
L
H
E
L
M
I
-
H
C
W
K
K
D
P
E
E
R
P
T
F
E
Y
L
Q
S
F
L
E
D
Y
F
-----------
243
Blastp_CBE
54.17
48%
-41
- C3 -
-
2XYN
5.8
-
ABL2_HUMAN
C:
[27-289]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
--
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
L
-
E
-
P
P-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
R
E
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
-
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
F
-----------
242
Blastp_CBE
53.94
48%
-37
- C3 -
-
3GVU
11.4
-
ABL2_HUMAN
A:
[23-289]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----------------------
M
----------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
L
-
E
-
P
P-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
R
E
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
-
S
R
------
G
D
T
Y
-
T
--------
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
-
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
F
-----------
245
Blastp_CBE
53.42
48%
-43
- C3 -
-
2XYN
7.6
-
ABL2_HUMAN
A:
[26-289]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
---
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
L
-
E
-
P
P-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
R
E
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
-
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
F
-----------
493
Blastp_CBE
53.24
42%
-121
- C3 -
-
5BPY
6.9
-
B:
[4-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
-
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
--------
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-------------------
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
260
Blastp_CBE
53.24
47%
-28
- C3 -
-
6HD4
11.3
-
ABL1_MOUSE
A:
[5-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
----
S
----
P
--------
N
-----------------------
Y
----------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
258
Blastp_CBE
53.23
47%
-33
- C3 -
-
6HD6
11.4
-
ABL1_MOUSE
A:
[5-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
----
S
----
P
--------
N
-----------------------
Y
----------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
----
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
290
Blastp_CBE
53.14
47%
-34
- C3 -
-
3QRK
8.4
-
ABL1_HUMAN
A:
[5-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
----
S
----
P
--------
N
-----------------------
Y
----------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------------
265
Blastp_CBE
53.12
47%
-34
- C3 -
-
3MS9
11.5
-
ABL1_MOUSE
B:
[5-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
----
S
----
P
--------
N
-----------------------
Y
----------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
----
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
322
Blastp_CBE
53.05
47%
-38
- C3 -
-
6NPE
10.9
-
ABL1_HUMAN
A:
[19-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
----------
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
241
Blastp_CBE
53.01
48%
-27
- C3 -
-
3HMI
7.0
-
ABL2_HUMAN
A:
[25-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
L
-
E
-
P
P-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
R
E
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
-
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
F
-----------
270
Blastp_CBE
52.99
47%
-36
- C3 -
-
1OPJ
11.2
-
ABL1_MOUSE
B:
[5-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
----
S
----
P
--------
N
-----------------------
Y
----------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
340
Blastp_CBE
52.97
47%
-27
- C3 -
-
2G2H
9.3
-
ABL1_HUMAN
A:
[8-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
P
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
339
Blastp_CBE
52.96
47%
-36
- C3 -
-
2G2H
9.8
-
ABL1_HUMAN
B:
[8-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
P
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
326
Blastp_CBE
52.95
47%
-36
- C3 -
-
3DK3
8.1
-
ABL1_MOUSE
A:
[4-268]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
---------
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
F
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
343
Blastp_CBE
52.93
47%
-36
- C3 -
-
3QRJ
9.4
-
ABL1_HUMAN
B:
[11-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
332
Blastp_CBE
52.85
47%
-44
- C3 -
-
3IK3
12.1
-
ABL1_MOUSE
A:
[6-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
---------T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
244
Blastp_CBE
52.83
48%
-41
- C3 -
-
2XYN
7.6
-
ABL2_HUMAN
B:
[26-289]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
---
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
L
-
E
-
P
P-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
R
E
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
-
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
F
-----------
301
Blastp_CBE
52.78
47%
-38
- C3 -
-
2E2B
11.2
-
ABL1_HUMAN
A:
[5-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
----
S
----
P
--------
N
-----------------------
Y
----------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-------
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
------T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
274
Blastp_CBE
52.77
47%
-38
- C3 -
-
1IEP
11.2
-
ABL1_MOUSE
B:
[5-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
----
S
----
P
--------
N
-----------------------
Y
----------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
300
Blastp_CBE
52.72
47%
-36
- C3 -
-
2E2B
11.7
-
ABL1_HUMAN
B:
[5-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
----
S
----
P
--------
N
-----------------------
Y
----------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-----------
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
---------T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
271
Blastp_CBE
52.63
47%
-30
- C3 -
-
1OPJ
11.1
-
ABL1_MOUSE
A:
[5-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
----
S
----
P
--------
N
-----------------------
Y
----------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
292
Blastp_CBE
52.59
47%
-34
- C3 -
-
3QRI
9.9
-
ABL1_HUMAN
A:
[5-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
----
S
----
P
--------
N
-----------------------
Y
----------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
334
Blastp_CBE
52.49
47%
-38
- C3 -
-
4TWP
8.0
-
ABL1_HUMAN
B:
[1-265]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
276
Blastp_CBE
52.55
47%
-34
- C3 -
-
1FPU
7.4
-
ABL1_MOUSE
B:
[5-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
----
S
----
P
--------
N
-----------------------
Y
----------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
--------T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
455
Blastp_CBE
52.49
42%
-50
- C3 -
-
6AUA
9.2
-
A:
[2-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
A
Y
-
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
A
N
--------
331
Blastp_CBE
52.52
47%
-40
- C3 -
-
3IK3
12.2
-
ABL1_MOUSE
B:
[6-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
259
Blastp_CBE
52.49
47%
-35
- C3 -
-
6HD4
11.2
-
ABL1_MOUSE
B:
[5-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
----
S
----
P
--------
N
-----------------------
Y
----------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
-----
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
291
Blastp_CBE
52.45
47%
-32
- C3 -
-
3QRI
10.2
-
ABL1_HUMAN
B:
[10-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
----------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-----------
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
277
Blastp_CBE
52.47
47%
-31
- C3 -
-
1FPU
9.0
-
ABL1_MOUSE
A:
[5-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
----
S
----
P
--------
N
-----------------------
Y
----------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
240
Blastp_CBE
52.45
48%
-33
- C3 -
-
4XLI
8.2
-
ABL2_MOUSE
A:
[1-265]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
---------
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
L
-
E
-
P
P-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
S
R
E
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
-
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
F
-----------
252
Blastp_CBE
52.44
48%
-36
- C3 -
-
3KFA
12.6
-
ABL1_MOUSE
A:
[6-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
253
Blastp_CBE
52.43
48%
-37
- C3 -
-
3KF4
9.3
-
ABL1_MOUSE
B:
[6-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
----
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
268
Blastp_CBE
52.39
47%
-29
- C3 -
-
3K5V
11.2
-
ABL1_MOUSE
A:
[5-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
----
S
----
P
--------
N
-----------------------
Y
----------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
318
Blastp_CBE
52.31
47%
-37
- C3 -
-
6NPV
11.4
-
ABL1_HUMAN
A:
[19-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
----------
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
306
Blastp_CBE
52.31
47%
-39
- C3 -
-
2HYY
11.1
-
ABL1_HUMAN
C:
[6-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
-
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
----T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
491
Blastp_CBE
52.26
42%
-122
- C3 -
-
5JRS
9.0
-
B:
[4-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
--
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
--------
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
----
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-------------------
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
273
Blastp_CBE
52.32
47%
-30
- C3 -
-
1M52
10.2
-
ABL1_MOUSE
A:
[10-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
----------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
263
Blastp_CBE
52.31
47%
-37
- C3 -
-
3MSS
11.4
-
ABL1_MOUSE
B:
[3-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
----
S
----
P
--------
N
-----------------------
Y
----------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
------------
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
--
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
335
Blastp_CBE
52.30
47%
-37
- C3 -
-
4TWP
7.6
-
ABL1_HUMAN
A:
[1-265]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-----------
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
328
Blastp_CBE
52.27
47%
-37
- C3 -
-
3OY3
11.6
-
ABL1_MOUSE
A:
[6-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
324
Blastp_CBE
52.27
47%
-36
- C3 -
-
3PYY
11.5
-
ABL1_HUMAN
A:
[19-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
---------
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
272
Blastp_CBE
52.29
47%
-30
- C3 -
-
1M52
10.1
-
ABL1_MOUSE
B:
[10-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
----------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
267
Blastp_CBE
52.27
47%
-34
- C3 -
-
3K5V
11.2
-
ABL1_MOUSE
B:
[5-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
----
S
----
P
--------
N
-----------------------
Y
----------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
-----
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
251
Blastp_CBE
52.27
48%
-36
- C3 -
-
3KFA
12.7
-
ABL1_MOUSE
B:
[6-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
333
Blastp_CBE
52.26
47%
-38
- C3 -
-
2Z60
8.5
-
ABL1_MOUSE
A:
[6-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
--------
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
370
Blastp_CBE
52.25
45%
-55
- C3 -
-
4HCV
8.1
-
A:
[5-257]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
V
I
D
P
S
E
L
--------
T
-
F
V
---------
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
-
R
E
G
A
--
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
-
T
R
F
V
-
L
-
D
D
Q
-
Y
-
T
---
S
-
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
278
Blastp_CBE
52.23
47%
-34
- C3 -
-
4WA9
9.0
-
ABL1_HUMAN
B:
[7-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
314
Blastp_CBE
52.22
47%
-34
- C3 -
-
3CS9
12.2
-
ABL1_HUMAN
A:
[10-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
---------
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
288
Blastp_CBE
52.18
47%
-28
- C3 -
-
2G1T
6.6
-
ABL1_HUMAN
B:
[8-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
297
Blastp_CBE
52.19
47%
-26
- C3 -
-
4ZOG
7.7
-
ABL1_HUMAN
A:
[5-269]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
256
Blastp_CBE
52.18
48%
-38
- C3 -
-
2QOH
8.1
-
ABL1_MOUSE
A:
[6-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
--------
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
327
Blastp_CBE
52.17
47%
-36
- C3 -
-
3OY3
11.5
-
ABL1_MOUSE
B:
[6-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
261
Blastp_CBE
52.13
47%
-36
- C3 -
-
3MSS
11.3
-
ABL1_MOUSE
D:
[3-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
----
S
----
P
--------
N
-----------------------
Y
----------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
------------
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
--
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
305
Blastp_CBE
52.12
47%
-33
- C3 -
-
2HYY
10.9
-
ABL1_HUMAN
D:
[6-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
----
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
344
Blastp_CBE
52.11
47%
-41
- C3 -
-
3QRJ
9.9
-
ABL1_HUMAN
A:
[12-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-----------
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------------
325
Blastp_CBE
52.06
47%
-40
- C3 -
-
3DK3
8.3
-
ABL1_MOUSE
B:
[4-268]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-------
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
F
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
336
Blastp_CBE
52.01
47%
-32
- C3 -
-
2F4J
7.7
-
ABL1_HUMAN
A:
[7-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
P
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
354
Blastp_CBE
51.95
44%
-54
- C3 -
-
3SXS
7.3
-
A:
[4-260]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
K
R
E
E
I
--------
T
-
L
L
---------
K
E
L
G
S
G
Q
F
G
V
V
K
L
G
K
W
K
-
G
---
Q
----
Y
D
V
A
V
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
F
Q
E
A
Q
T
M
M
K
L
S
H
P
K
L
V
K
F
Y
G
V
C
S
-
K
-
E
Y
P
--
I
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
S
-
H
G
K
G
L
E
P
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
D
R
D
L
C
V
K
V
S
D
F
G
M
-
T
R
Y
V
-
L
-
D
D
Q
-
Y
-
V
---
S
-
S
V
G
T
K
-
F
P
V
K
W
S
A
P
E
V
F
H
Y
F
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
T
N
S
E
V
V
L
K
V
S
Q
G
H
R
L
Y
R
P
H
L
A
S
D
T
I
Y
Q
-
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
E
--------------
308
Blastp_CBE
51.86
47%
-34
- C3 -
-
2HYY
10.8
-
ABL1_HUMAN
A:
[8-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
-
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
320
Blastp_CBE
51.87
47%
-35
- C3 -
-
6NPU
11.3
-
ABL1_HUMAN
A:
[19-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
----------
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
275
Blastp_CBE
51.84
47%
-32
- C3 -
-
1IEP
11.1
-
ABL1_MOUSE
A:
[5-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
----
S
----
P
--------
N
-----------------------
Y
----------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
262
Blastp_CBE
51.84
47%
-31
- C3 -
-
3MSS
11.5
-
ABL1_MOUSE
C:
[3-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
----
S
----
P
--------
N
-----------------------
Y
----------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
------------
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
--
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
307
Blastp_CBE
51.83
47%
-34
- C3 -
-
2HYY
11.2
-
ABL1_HUMAN
B:
[6-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
-
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
255
Blastp_CBE
51.82
48%
-34
- C3 -
-
2QOH
8.5
-
ABL1_MOUSE
B:
[6-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
-----
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
257
Blastp_CBE
51.80
47%
-40
- C3 -
-
6HD6
11.3
-
ABL1_MOUSE
B:
[5-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
----
S
----
P
--------
N
-----------------------
Y
----------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
-----
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
496
Blastp_CBE
51.73
43%
-66
- C3 -
-
1BYG
7.6
-
CSK_HUMAN
A:
[15-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
W
-------------------
A
L
N
M
K
E
L
--------
K
-
L
L
---------
Q
T
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
R
-
G
---
N
-----
K
V
A
V
K
C
I
-
K
N
D
--------
A
Q
---
A
F
L
A
E
A
S
V
M
T
Q
L
R
H
S
N
L
V
Q
L
L
G
V
I
V
-
E
-
E
--G-
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
S
R
G
R
S
V
L
G
G
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
E
D
N
V
A
K
V
S
D
F
G
L
--------------------------
L
P
V
K
W
T
A
P
E
A
L
R
E
K
K
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
R
V
P
Y
P
R
I
P
L
K
D
V
V
P
R
V
E
K
G
Y
K
M
D
A
P
D
G
C
P
P
A
V
Y
E
-
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
Q
L
E
H
I
K
T
----------
287
Blastp_CBE
51.78
47%
-29
- C3 -
-
2G1T
6.1
-
ABL1_HUMAN
C:
[8-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
436
Blastp_CBE
51.73
42%
-72
- C3 -
-
5FBO
10.6
-
A:
[7-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-----------------------
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
366
Blastp_CBE
51.73
45%
-46
- C3 -
-
4M13
9.2
-
A:
[4-257]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
V
I
D
P
S
E
L
--------
T
-
F
V
---------
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
-
R
E
G
A
--
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
-
T
R
F
V
-
L
-
D
D
Q
-
Y
-
T
---
S
-
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
315
Blastp_CBE
51.68
47%
-38
- C3 -
-
2HZI
10.7
-
ABL1_HUMAN
B:
[10-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-------
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
342
Blastp_CBE
51.66
47%
-27
- C3 -
-
2G2F
4.3
-
ABL1_HUMAN
A:
[8-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
P
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
367
Blastp_CBE
51.60
45%
-51
- C3 -
-
4M12
8.7
-
A:
[4-257]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
V
I
D
P
S
E
L
--------
T
-
F
V
---------
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
-
R
E
G
A
--
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
-
T
R
F
V
-
L
-
D
D
Q
-
Y
-
T
---
S
-
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
286
Blastp_CBE
51.62
47%
-28
- C3 -
-
2G1T
4.3
-
ABL1_HUMAN
D:
[8-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
254
Blastp_CBE
51.60
48%
-34
- C3 -
-
3KF4
9.4
-
ABL1_MOUSE
A:
[6-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
----------
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
431
Blastp_CBE
51.57
42%
-59
- C3 -
-
6DI3
7.3
-
A:
[7-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
--
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
----------------
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
316
Blastp_CBE
51.56
47%
-27
- C3 -
-
2HZI
10.7
-
ABL1_HUMAN
A:
[10-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
369
Blastp_CBE
51.51
45%
-55
- C3 -
-
4M0Y
6.9
-
A:
[5-257]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
V
I
D
P
S
E
L
--------
T
-
F
V
---------
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
-
R
E
G
A
--
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
-
T
R
F
V
-
L
-
D
D
Q
-
Y
-
T
---
S
-
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
266
Blastp_CBE
51.52
47%
-27
- C3 -
-
3MS9
11.6
-
ABL1_MOUSE
A:
[3-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
----
S
----
P
--------
N
-----------------------
Y
----------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
------------
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
----
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
311
Blastp_CBE
51.51
47%
-41
- C3 -
-
3CS9
11.1
-
ABL1_HUMAN
D:
[10-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------------
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
426
Blastp_CBE
51.46
42%
-48
- C3 -
-
6OMU
6.4
-
A:
[7-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
428
Blastp_CBE
51.50
42%
-51
- C3 -
-
6N9P
6.9
-
A:
[7-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
289
Blastp_CBE
51.49
47%
-31
- C3 -
-
2G1T
6.4
-
ABL1_HUMAN
A:
[8-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
501
Blastp_CBE
51.48
42%
-50
- C3 -
-
6BKE
9.5
-
A:
[4-262]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
-
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
285
Blastp_CBE
51.46
47%
-31
- C3 -
-
3UE4
6.7
-
ABL1_HUMAN
A:
[8-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
264
Blastp_CBE
51.44
47%
-31
- C3 -
-
3MSS
11.6
-
ABL1_MOUSE
A:
[3-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
----
S
----
P
--------
N
-----------------------
Y
----------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
------------
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
--
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
460
Blastp_CBE
51.30
43%
-46
- C3 -
-
4Y93
9.2
-
?
A:
[183-441]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
M
-
T
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
T
G
S
K
-
F
P
V
K
W
A
S
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
P
R
P
H
L
A
S
E
R
V
Y
-
A
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
269
Blastp_CBE
51.31
47%
-33
- C3 -
-
2HZN
6.8
-
ABL1_MOUSE
A:
[5-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
----
S
----
P
--------
N
-----------------------
Y
----------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
---
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
---
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
415
Blastp_CBE
51.30
42%
-77
- C3 -
-
3PJ2
7.8
-
A:
[10-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
---
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
----------------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
299
Blastp_CBE
51.28
47%
-33
- C3 -
-
2HIW
9.4
-
ABL1_HUMAN
A:
[8-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
449
Blastp_CBE
51.25
42%
-44
- C3 -
-
5P9K
6.4
-
A:
[15-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
284
Blastp_CBE
51.24
47%
-29
- C3 -
-
3UE4
7.7
-
ABL1_HUMAN
B:
[8-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
--
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
294
Blastp_CBE
51.19
47%
-24
- C3 -
-
6BL8
7.2
-
ABL1_HUMAN
A:
[1-265]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
F
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
239
Blastp_CBE
51.19
48%
-27
- C3 -
-
4XLI
7.2
-
B:
[1-265]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
----
G
E
V
Y
V
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
L
-
E
-
P
P-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
S
R
E
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
-
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
F
-----------
439
Blastp_CBE
51.15
42%
-48
- C3 -
-
6NZM
10.7
-
D:
[16-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R---
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
310
Blastp_CBE
51.12
47%
-33
- C3 -
-
2HZ0
10.2
-
ABL1_HUMAN
A:
[6-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
498
Blastp_CBE
51.05
42%
-47
- C3 -
-
6BLN
8.6
-
A:
[4-262]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
-
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
469
Blastp_CBE
51.09
42%
-52
- C3 -
-
4OT6
6.9
-
A:
[19-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
R
H
A
-
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
392
Blastp_CBE
51.07
42%
-50
- C3 -
-
6AUB
9.8
-
A:
[1-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
447
Blastp_CBE
51.06
42%
-47
- C3 -
-
5P9M
7.6
-
A:
[15-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
298
Blastp_CBE
51.05
47%
-34
- C3 -
-
2HIW
9.5
-
ABL1_HUMAN
B:
[8-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
442
Blastp_CBE
51.04
42%
-46
- C3 -
-
4ZLY
4.2
-
A:
[7-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
365
Blastp_CBE
51.00
45%
-44
- C3 -
-
4M14
8.3
-
A:
[4-257]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
V
I
D
P
S
E
L
--------
T
-
F
V
---------
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
-
R
E
G
A
--
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
-
T
R
F
V
-
L
-
D
D
Q
-
Y
-
T
---
S
-
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
371
Blastp_CBE
51.02
45%
-54
- C3 -
-
4HCU
8.3
-
A:
[5-257]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
V
I
D
P
S
E
L
--------
T
-
F
V
---------
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
-
R
E
G
A
--
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
-
T
R
F
V
-
L
-
D
D
Q
-
Y
-
T
---
S
-
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
359
Blastp_CBE
51.00
46%
-53
- C3 -
-
3T9T
6.1
-
A:
[3-255]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
V
I
D
P
S
E
L
--------
T
-
F
V
---------
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
-
R
E
G
A
--
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
T
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
-
T
R
F
V
-
L
-
D
D
Q
-
Y
-
T
---
S
-
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
404
Blastp_CBE
50.94
42%
-49
- C3 -
-
4RX5
8.5
-
A:
[4-262]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
368
Blastp_CBE
50.96
45%
-49
- C3 -
-
4M0Z
5.3
-
A:
[4-257]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
V
I
D
P
S
E
L
--------
T
-
F
V
---------
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
-
R
E
G
A
--
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
-
T
R
F
V
-
L
-
D
D
Q
-
Y
-
T
---
S
-
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
406
Blastp_CBE
50.95
42%
-48
- C3 -
-
6J6M
8.3
-
?
A:
[5-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
401
Blastp_CBE
50.94
42%
-51
- C3 -
-
6S90
10.3
-
BTK_HUMAN
A:
[3-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
452
Blastp_CBE
50.93
42%
-44
- C3 -
-
5P9H
8.3
-
A:
[15-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
293
Blastp_CBE
50.92
47%
-36
- C3 -
-
6BL8
6.2
-
ABL1_HUMAN
B:
[1-265]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
---
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
F
-
T
---
A
-
H
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
372
Blastp_CBE
50.91
45%
-53
- C3 -
-
4HCT
8.4
-
A:
[4-257]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
V
I
D
P
S
E
L
--------
T
-
F
V
---------
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
-
R
E
G
A
--
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
-
T
R
F
V
-
L
-
D
D
Q
-
Y
-
T
---
S
-
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
456
Blastp_CBE
50.82
42%
-49
- C3 -
-
5BQ0
7.3
-
A:
[19-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-----------
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
427
Blastp_CBE
50.87
42%
-46
- C3 -
-
6NFH
7.2
-
A:
[7-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
435
Blastp_CBE
50.82
42%
-44
- C3 -
-
5U9D
10.0
-
A:
[7-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
434
Blastp_CBE
50.82
42%
-47
- C3 -
-
5VFI
10.6
-
A:
[7-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
430
Blastp_CBE
50.82
42%
-47
- C3 -
-
6DI5
7.2
-
A:
[7-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
402
Blastp_CBE
50.81
42%
-50
- C3 -
-
5VGO
9.8
-
A:
[4-262]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
457
Blastp_CBE
50.78
42%
-49
- C3 -
-
3GEN
8.8
-
A:
[19-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
---
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
450
Blastp_CBE
50.75
42%
-49
- C3 -
-
5P9J
8.6
-
A:
[15-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
-------
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
234
Blastp_CBE
50.73
60%
-17
- C3 -
-
4UEU
3.9
-
?
A:
[3-268]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
----------------
D
K
W
-------------------
E
I
P
R
S
E
I
--------
T
-
L
E
---------
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
R
-
N
Y--
N
----
I
E
V
A
V
K
T
L
-
K
E
G
T
--
M
---
S
V
E
---
E
F
L
Q
E
A
Q
I
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
T
-
K
-
E
-
P
P-
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
C
E
G
H
T
V
N
A
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
V
K
V
A
D
F
G
L
-
A
R
-
L
-
I
----------------
A
K
-
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
G
S
E
V
I
E
Q
V
E
R
G
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
-
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
F
-----------
381
Blastp_CBE
50.72
42%
-80
- C3 -
-
3OCT
8.9
-
A:
[4-262]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
--
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
-----
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
-----------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
400
Blastp_CBE
50.57
42%
-47
- C3 -
-
6S90
10.7
-
B:
[3-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
499
Blastp_CBE
50.61
42%
-46
- C3 -
-
6BKW
8.9
-
A:
[4-262]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
-
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
484
Blastp_CBE
50.59
45%
-84
- C3 -
-
4L7S
7.0
-
ITK_HUMAN
A:
[9-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
---------
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
-
R
E
G
A
--
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
-
T
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
338
Blastp_CBE
50.57
47%
-30
- C3 -
-
2G2I
4.0
-
ABL1_HUMAN
A:
[8-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
---
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
P
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
467
Blastp_CBE
50.49
42%
-49
- C3 -
-
4OTR
10.5
-
A:
[20-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
R
H
A
-
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
413
Blastp_CBE
50.47
42%
-47
- C3 -
-
3OCS
9.8
-
A:
[4-262]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
337
Blastp_CBE
50.45
47%
-31
- C3 -
-
2G2I
3.6
-
ABL1_HUMAN
B:
[8-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
----
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
P
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
356
Blastp_CBE
50.41
44%
-53
- C3 -
-
3SXR
8.2
-
BMX_HUMAN
A:
[4-260]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
K
R
E
E
I
--------
T
-
L
L
---------
K
E
L
G
S
----
V
V
K
L
G
K
W
K
-
G
---
Q
----
Y
D
V
A
V
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
F
Q
E
A
Q
T
M
M
K
L
S
H
P
K
L
V
K
F
Y
G
V
C
S
-
K
-
E
Y
P
--
I
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
S
-
H
G
K
G
L
E
P
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
D
R
D
L
C
V
K
V
S
D
F
G
M
-
T
R
Y
V
-
L
-
D
D
Q
-
Y
-
V
---
S
-
S
V
G
T
K
-
F
P
V
K
W
S
A
P
E
V
F
H
Y
F
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
T
N
S
E
V
V
L
K
V
S
Q
G
H
R
L
Y
R
P
H
L
A
S
D
T
I
Y
Q
-
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
E
--------------
403
Blastp_CBE
50.44
42%
-48
- C3 -
-
5KUP
10.0
-
A:
[4-262]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
502
Blastp_CBE
50.42
42%
-44
- C3 -
-
6BIK
9.3
-
A:
[4-262]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
-
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
296
Blastp_CBE
50.41
47%
-27
- C3 -
-
4ZOG
7.7
-
ABL1_HUMAN
B:
[6-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
------
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
454
Blastp_CBE
50.37
42%
-46
- C3 -
-
5P9F
10.2
-
A:
[15-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
433
Blastp_CBE
50.36
42%
-47
- C3 -
-
6DI0
4.1
-
A:
[7-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
464
Blastp_CBE
50.34
42%
-49
* C3 *
-
4RG0
10.2
-
A:
[20-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
R
H
A
-
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
458
Blastp_CBE
50.23
42%
-41
- C3 -
-
6E4F
8.9
-
A:
[26-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
459
Blastp_CBE
50.27
42%
-43
- C3 -
-
4Z3V
6.7
-
A:
[19-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
441
Blastp_CBE
50.26
42%
-44
- C3 -
-
4ZLZ
5.4
-
A:
[7-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
417
Blastp_CBE
50.25
42%
-71
- C3 -
-
3PIZ
7.1
-
A:
[10-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
---
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-----------
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
--------------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
451
Blastp_CBE
50.24
42%
-46
- C3 -
-
5P9I
9.3
-
A:
[15-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
364
Blastp_CBE
50.23
45%
-45
- C3 -
-
4M15
5.2
-
A:
[4-257]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
V
I
D
P
S
E
L
--------
T
-
F
V
---------
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
-
R
E
G
A
--
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
-
T
R
F
V
-
L
-
D
D
Q
-
Y
-
T
---
S
-
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
453
Blastp_CBE
50.15
42%
-43
- C3 -
-
5P9G
10.1
-
A:
[15-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
341
Blastp_CBE
50.20
47%
-28
- C3 -
-
2G2F
3.7
-
ABL1_HUMAN
B:
[9-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
-----
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
P
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
411
Blastp_CBE
50.15
42%
-46
- C3 -
-
4YHF
9.3
-
B:
[14-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
373
Blastp_CBE
50.13
46%
-84
- C3 -
-
4RFM
6.7
-
A:
[9-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
---------
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
-
R
E
G
A
--
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
-
T
R
-----------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
419
Blastp_CBE
50.06
42%
-44
- C3 -
-
3PIX
5.6
-
A:
[10-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
461
Blastp_CBE
50.08
42%
-49
- C3 -
-
6HRT
11.3
-
A:
[20-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
R
H
A
-
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
432
Blastp_CBE
50.07
42%
-48
- C3 -
-
6DI1
3.8
-
A:
[7-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
283
Blastp_CBE
50.06
47%
-32
- C3 -
-
4YC8
5.7
-
ABL1_HUMAN
A:
[8-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
------
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-------
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
303
Blastp_CBE
50.03
47%
-30
- C3 -
-
2HZ4
8.2
-
ABL1_HUMAN
B:
[6-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
-----
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
489
Blastp_CBE
49.93
41%
-54
- C3 -
-
6MNY
7.3
-
?
A:
[12-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
R
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-----------------
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
A
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
R
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
S
F
K
I
L
L
S
N
I
L
D
-------------
444
Blastp_CBE
49.97
42%
-40
- C3 -
-
5J87
9.2
-
BTK_HUMAN
C:
[12-269]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
445
Blastp_CBE
49.96
42%
-46
- C3 -
-
5J87
9.3
-
BTK_HUMAN
B:
[11-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
235
Blastp_CBE
49.95
60%
-6
- C3 -
-
4CSV
10.3
-
?
A:
[5-268]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
I
P
R
S
E
I
--------
T
-
L
E
---------
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
R
-
N
Y--
N
----
I
E
V
A
V
K
T
L
-
K
E
G
T
--
M
---
S
V
E
---
E
F
L
Q
E
A
Q
I
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
T
-
K
-
E
-
P
P-
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
C
----
V
N
A
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
V
K
V
A
D
F
G
---------------------------
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
G
S
E
V
I
E
Q
V
E
R
G
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
-
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
F
-----------
463
Blastp_CBE
49.89
42%
-47
- C3 -
-
6EP9
9.8
-
A:
[20-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
R
H
A
-
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
438
Blastp_CBE
49.93
42%
-57
- C3 -
-
5FBN
11.1
-
BTK_HUMAN
C:
[7-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
--------------
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
466
Blastp_CBE
49.91
42%
-47
- C3 -
-
4RFY
9.6
-
A:
[20-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
R
H
A
-
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
393
Blastp_CBE
49.89
46%
-83
- C3 -
-
1SNU
7.3
-
B:
[7-249]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
---------
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
-
R
E
G
A
--
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
-----------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
----------------------
500
Blastp_CBE
49.88
42%
-42
- C3 -
-
6BKH
9.1
-
A:
[5-262]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
-
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
462
Blastp_CBE
49.82
42%
-47
- C3 -
-
6HRP
10.1
-
A:
[20-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
R
H
A
-
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
446
Blastp_CBE
49.81
42%
-45
- C3 -
-
5J87
9.5
-
BTK_HUMAN
A:
[12-269]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
412
Blastp_CBE
49.80
42%
-51
- C3 -
-
4YHF
8.8
-
BTK_HUMAN
A:
[14-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
495
Blastp_CBE
49.70
42%
-69
- C3 -
-
3K54
7.4
-
A:
[19-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
---------------
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
---------------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
494
Blastp_CBE
49.75
42%
-45
- C3 -
-
5BPY
7.1
-
BTK_HUMAN
A:
[4-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
382
Blastp_CBE
49.70
46%
-77
- C3 -
-
3V8W
3.5
-
B:
[9-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
---------
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
-
R
-----
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
----------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
468
Blastp_CBE
49.67
42%
-47
- C3 -
-
4OTQ
9.3
-
A:
[20-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
R
H
A
-
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
490
Blastp_CBE
49.65
42%
-49
- C3 -
-
5T18
8.8
-
A:
[4-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
----
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
465
Blastp_CBE
49.64
42%
-44
- C3 -
-
4RFZ
10.0
-
A:
[20-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
R
H
A
-
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
492
Blastp_CBE
49.56
42%
-49
- C3 -
-
5JRS
9.0
-
BTK_HUMAN
A:
[4-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
----
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
387
Blastp_CBE
49.53
46%
-77
- C3 -
-
3V5L
7.2
-
ITK_HUMAN
C:
[9-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
---------
Q
E
I
G
S
---
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
-
R
E
G
A
--
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
-
T
------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
470
Blastp_CBE
49.45
42%
-48
- C3 -
-
4OT5
10.1
-
A:
[20-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
R
H
A
-
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
390
Blastp_CBE
49.44
46%
-85
- C3 -
-
3V5J
6.8
-
B:
[9-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
---------
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
-------
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
-----------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
480
Blastp_CBE
49.38
45%
-79
- C3 -
-
4PP9
4.8
-
ITK_HUMAN
A:
[9-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
---------
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
-
R
E
G
A
--
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
----------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
282
Blastp_CBE
49.40
47%
-29
- C3 -
-
4YC8
4.0
-
ABL1_HUMAN
B:
[8-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
------
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
357
Blastp_CBE
49.38
46%
-24
- C3 -
-
6CZ4
9.8
-
PTK6_HUMAN
A:
[4-262]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
-------------------
E
R
P
R
E
E
F
--------
T
-
L
C
---------
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
K
-
D
---
R
----
V
Q
V
A
I
K
V
I
S
R
D
N
L
--
L
---
H
Q
Q
---
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
G
-
D
-
P
--
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
D
S
D
E
K
V
L
P
V
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
L
C
K
V
G
D
F
G
L
-
A
R
-
L
-
I
-
K
E
D
-
V
-
Y
---
L
-
S
H
-----
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
S
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
-
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
C
F
K
A
L
R
E
R
L
---------------
418
Blastp_CBE
49.37
42%
-47
- C3 -
-
3PIY
7.7
-
A:
[10-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
------------
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
377
Blastp_CBE
49.33
46%
-49
- C3 -
-
3MJ2
6.4
-
A:
[9-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
---------
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
-
R
E
G
A
--
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
-
T
R
F
V
-
L
-
D
D
Q
-
Y
-
T
---
S
-
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
250
Blastp_CBE
49.32
48%
-16
- C3 -
-
3OXZ
11.8
-
ABL1_MOUSE
A:
[6-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
------------
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
------------------
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
448
Blastp_CBE
49.31
42%
-55
- C3 -
-
5P9L
5.4
-
A:
[15-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
----
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-----------------
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
483
Blastp_CBE
49.25
45%
-79
- C3 -
-
4L7S
6.1
-
B:
[9-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
---------
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
-
R
E
G
A
--
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
-
T
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
383
Blastp_CBE
49.30
46%
-83
- C3 -
-
3V8W
3.6
-
ITK_HUMAN
A:
[9-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
---------
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
-
R
-
G
A
--
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
----------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
-
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
384
Blastp_CBE
49.27
46%
-84
- C3 -
-
3V8T
6.1
-
B:
[9-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
---------
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
----
A
--
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
-
T
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
394
Blastp_CBE
49.23
46%
-83
- C3 -
-
1SNU
7.4
-
ITK_HUMAN
A:
[7-249]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
---------
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
-
R
E
G
A
--
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
----------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
----------------------
479
Blastp_CBE
49.26
45%
-82
- C3 -
-
4PP9
4.9
-
B:
[9-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
---------
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
-
R
E
G
A
--
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
---------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
348
Blastp_CBE
49.25
46%
-16
- C3 -
-
5H2U
7.2
-
PTK6_HUMAN
A:
[2-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
P
R
E
E
F
--------
T
-
L
C
---------
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
K
-
D
---
R
----
V
Q
V
A
I
K
V
I
S
R
D
N
L
--
L
---
H
Q
Q
---
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
G
-
D
-
P
--
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
-
S
D
E
K
V
L
P
V
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
L
C
K
V
G
D
F
G
L
-
A
R
-
L
-
I
-
K
E
D
-
V
-
Y
---
L
-
S
H
D
H
N
-
I
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
S
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
-
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
R
E
R
L
S
S
F
------------
358
Blastp_CBE
49.23
46%
-20
- C3 -
-
6CZ3
5.5
-
PTK6_HUMAN
A:
[3-262]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
A
-------------------
E
R
P
R
E
E
F
--------
T
-
L
C
---------
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
K
-
D
---
R
----
V
Q
V
A
I
K
V
I
S
R
D
N
L
--
L
---
H
Q
Q
---
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
G
-
D
-
P
--
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
D
S
D
E
K
V
L
P
V
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
L
C
K
V
G
D
F
G
L
-
A
R
-
L
-
I
-
K
E
D
-
V
-
Y
---
L
-
S
H
D
H
N
-
I
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
S
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
-
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
C
F
K
A
L
R
E
R
L
---------------
485
Blastp_CBE
49.07
45%
-78
- C3 -
-
4KIO
4.5
-
D:
[9-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
---------
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
-----------
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
---------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
395
Blastp_CBE
49.07
46%
-85
- C3 -
-
1SM2
8.3
-
B:
[7-249]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
---------
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
-
R
E
G
A
--
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
-----------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
----------------------
353
Blastp_CBE
49.07
46%
-12
- C3 -
-
5D7V
1.9
-
PTK6_HUMAN
A:
[2-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
P
R
E
E
F
--------
T
-
L
C
---------
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
K
-
D
---
R
----
V
Q
V
A
I
K
V
I
S
R
D
N
L
--
L
---
H
Q
Q
---
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
G
-
D
-
P
--
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
D
S
D
E
K
V
L
P
V
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
L
C
K
V
G
D
F
G
L
-
A
R
-
L
-
I
-
K
E
D
-
V
-
Y
---
L
-
S
H
D
H
N
-
I
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
S
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
-
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
R
E
R
L
S
S
F
------------
386
Blastp_CBE
49.03
46%
-79
- C3 -
-
3V5L
7.2
-
D:
[9-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
---------
Q
E
I
G
S
G
Q
-
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
-
R
--
A
--
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
--------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
351
Blastp_CBE
49.03
46%
-14
- C3 -
-
5D7V
1.9
-
PTK6_HUMAN
C:
[2-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
P
R
E
E
F
--------
T
-
L
C
---------
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
K
-
D
---
R
----
V
Q
V
A
I
K
V
I
S
R
D
N
L
--
L
---
H
Q
Q
---
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
G
-
D
-
P
--
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
D
S
D
E
K
V
L
P
V
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
L
C
K
V
G
D
F
G
L
-
A
R
-
L
-
I
-
K
E
D
-
V
-
Y
---
L
-
S
H
D
H
N
-
I
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
S
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
-
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
R
E
R
L
S
S
F
------------
396
Blastp_CBE
49.00
46%
-80
- C3 -
-
1SM2
7.4
-
ITK_HUMAN
A:
[7-249]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
---------
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
-
R
E
G
A
--
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
----------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
----------------------
486
Blastp_CBE
48.88
45%
-75
- C3 -
-
4KIO
4.5
-
ITK_HUMAN
C:
[9-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
---------
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
-
R
E
G
A
--
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
-
T
------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
347
Blastp_CBE
48.87
46%
-15
- C3 -
-
5H2U
7.0
-
PTK6_HUMAN
B:
[2-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
P
R
E
E
F
--------
T
-
L
C
---------
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
K
-
D
---
R
----
V
Q
V
A
I
K
V
I
S
R
D
N
L
--
L
---
H
Q
Q
---
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
G
-
D
-
P
--
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
-
S
D
E
K
V
L
P
V
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
L
C
K
V
G
D
F
G
L
-
A
R
-
L
-
I
-
K
E
D
-
V
-
Y
---
L
-
S
H
D
H
N
-
I
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
S
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
-
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
R
E
R
L
S
S
F
------------
346
Blastp_CBE
48.81
46%
-15
- C3 -
-
5H2U
6.9
-
PTK6_HUMAN
C:
[2-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
P
R
E
E
F
--------
T
-
L
C
---------
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
K
-
D
---
R
----
V
Q
V
A
I
K
V
I
S
R
D
N
L
--
L
---
H
Q
Q
---
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
G
-
D
-
P
--
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
-
S
D
E
K
V
L
P
V
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
L
C
K
V
G
D
F
G
L
-
A
R
-
L
-
I
-
K
E
D
-
V
-
Y
---
L
-
S
H
D
H
N
-
I
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
S
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
-
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
R
E
R
L
S
S
F
------------
443
Blastp_CBE
48.76
42%
-38
- C3 -
-
5J87
7.7
-
D:
[12-269]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
437
Blastp_CBE
48.76
42%
-54
- C3 -
-
5FBN
11.3
-
D:
[7-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
-----------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
391
Blastp_CBE
48.76
46%
-78
- C3 -
-
3V5J
6.5
-
ITK_HUMAN
A:
[9-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
---------
Q
E
I
G
S
G
Q
-
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
-
R
E
G
-------
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
----------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
-
R
S
N
S
E
V
V
E
D
I
S
T
G
-
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
350
Blastp_CBE
48.47
46%
-15
- C3 -
-
5D7V
2.3
-
PTK6_HUMAN
D:
[2-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
P
R
E
E
F
--------
T
-
L
C
---------
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
K
-
D
---
R
----
V
Q
V
A
I
K
V
I
S
R
D
N
L
--
L
---
H
Q
Q
---
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
G
-
D
-
P
--
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
D
S
D
E
K
V
L
P
V
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
L
C
K
V
G
D
F
G
L
-
A
R
-
L
-
I
-
K
E
D
-
V
-
Y
---
L
-
S
H
D
H
N
-
I
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
S
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
-
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
R
E
R
L
S
S
F
------------
388
Blastp_CBE
48.43
46%
-79
- C3 -
-
3V5L
7.3
-
ITK_HUMAN
B:
[9-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
---------
Q
E
I
G
S
----
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
-
R
---------
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
-
T
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
295
Blastp_CBE
48.42
47%
-15
- C3 -
-
5HU9
11.4
-
ABL1_HUMAN
A:
[10-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
---------------
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
352
Blastp_CBE
48.31
46%
-11
- C3 -
-
5D7V
3.2
-
PTK6_HUMAN
B:
[2-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
P
R
E
E
F
--------
T
-
L
C
---------
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
K
-
D
---
R
----
V
Q
V
A
I
K
V
I
S
R
D
N
L
--
L
---
H
Q
Q
---
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
G
-
D
-
P
--
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
D
S
D
E
K
V
L
P
V
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
L
C
K
V
G
D
F
G
L
-
A
R
-
L
-
I
-
K
E
D
-
V
-
Y
---
L
-
S
H
D
H
N
-
I
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
S
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
-
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
R
E
R
L
S
S
F
------------
487
Blastp_CBE
48.28
45%
-86
- C3 -
-
4KIO
4.8
-
ITK_HUMAN
B:
[9-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
---------
Q
E
I
G
S
---
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
-------------
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
-
T
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
429
Blastp_CBE
48.22
42%
-57
- C3 -
-
6DI9
5.4
-
A:
[7-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
------
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
E
G
S
--
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-----------------
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
405
Blastp_CBE
48.20
42%
-41
- C3 -
-
6O8I
5.3
-
A:
[5-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
----------------
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
Y
V
-
L
-
D
D
E
-
Y
-
T
---
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
374
Blastp_CBE
48.17
46%
-82
- C3 -
-
4PQN
5.7
-
A:
[9-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
---------
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
-
R
E
G
A
--
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
---------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
414
Blastp_CBE
48.15
42%
-72
- C3 -
-
3PJ3
10.5
-
A:
[10-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
G
T
---
G
V
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-------------
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
-----------------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
389
Blastp_CBE
48.11
46%
-77
- C3 -
-
3V5L
7.5
-
ITK_HUMAN
A:
[9-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
---------
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
-------
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
-
T
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
349
Blastp_CBE
47.98
46%
-13
- C3 -
-
5DA3
5.9
-
PTK6_HUMAN
A:
[2-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
P
R
E
E
F
--------
T
-
L
C
---------
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
K
-
D
---
R
----
V
Q
V
A
I
K
V
I
S
R
D
N
L
--
L
---
H
-
Q
---
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
G
-
D
-
P
--
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
D
S
D
E
K
V
L
P
V
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
L
C
K
V
G
D
F
G
L
-
A
R
-
L
-
I
-
K
E
D
-
V
-
Y
---
L
-
S
H
D
H
N
-
I
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
S
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
-
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
R
E
R
L
S
S
F
------------
380
Blastp_CBE
48.01
46%
-73
- C3 -
-
3MIY
6.7
-
ITK_HUMAN
A:
[9-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
---------
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
-----------
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
-----------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
488
Blastp_CBE
47.93
45%
-82
- C3 -
-
4KIO
5.9
-
ITK_HUMAN
A:
[9-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
---------
Q
E
I
G
S
---
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
------------
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
-
T
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
319
Blastp_CBE
47.98
47%
-15
- C3 -
-
6NPU
11.2
-
ABL1_HUMAN
B:
[19-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
------------
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
------------------------
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
375
Blastp_CBE
47.93
46%
-74
- C3 -
-
4MF1
4.9
-
B:
[9-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
---------
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
----
A
--
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
-
T
R
-----------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
248
Blastp_CBE
47.92
47%
-30
- C3 -
-
2GQG
8.3
-
ABL1_HUMAN
B:
[5-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
----
S
----
P
--------
N
-----------------------
Y
----------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
-
T
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
399
Blastp_CBE
47.77
42%
-80
- C3 -
-
5XYZ
6.9
-
BTK_HUMAN
A:
[4-262]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
-------
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
-----
M
---
S
E
D
------
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
---
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
-----------------------
F
P
V
R
W
S
P
P
E
V
L
M
---
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
503
Blastp_CBE
47.73
44%
-32
- C3 -
-
3D7T
7.9
-
CSK_HUMAN
A:
[7-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
A
L
N
M
K
E
L
--------
K
-
L
L
---------
Q
T
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
R
-
G
---
N
-----
K
V
A
V
K
C
I
-
K
N
D
A
------
T
A
Q
---
A
F
L
A
E
A
S
V
M
T
Q
L
R
H
S
N
L
V
Q
L
L
G
V
I
V
-
E
-
E
-
K
GG
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
S
R
G
R
S
V
L
G
G
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
E
D
N
V
A
K
V
S
D
F
G
----------------------------
P
V
K
W
T
A
P
E
A
L
R
E
A
A
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
R
V
P
Y
P
R
I
P
L
K
D
V
V
P
R
V
E
K
G
Y
K
M
D
A
P
D
G
C
P
P
A
V
Y
E
-
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
Q
L
E
H
I
K
T
----------
345
Blastp_CBE
47.67
46%
-16
- C3 -
-
5H2U
7.1
-
PTK6_HUMAN
D:
[2-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
P
R
E
E
F
--------
T
-
L
C
---------
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
K
-
D
---
R
----
V
Q
V
A
I
K
V
I
S
R
D
N
L
--
L
---
H
Q
Q
---
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
G
-
D
-
P
--
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
-
S
D
E
K
V
L
P
V
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
L
C
K
V
G
D
F
G
L
-
A
R
-
L
-
I
-
K
E
D
-
V
-
Y
---
L
-
S
H
D
H
N
-
I
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
S
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
-
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
R
E
R
L
S
S
F
------------
385
Blastp_CBE
47.58
46%
-80
- C3 -
-
3V8T
6.2
-
ITK_HUMAN
A:
[9-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
---------
Q
E
I
G
S
---
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
-
R
E
G
A
--
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
---------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
------
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
249
Blastp_CBE
47.58
47%
-33
- C3 -
-
2GQG
7.8
-
ABL1_HUMAN
A:
[5-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
----
S
----
P
--------
N
-----------------------
Y
----------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
-
T
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
398
Blastp_CBE
47.56
42%
-80
- C3 -
-
5XYZ
7.0
-
B:
[4-262]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
---------
K
E
L
-------
V
K
Y
G
K
W
R
-
G
---
Q
----
Y
D
V
A
I
K
M
I
-
K
-----
M
---
S
E
D
---
E
-
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-
S
R
-----------------------
F
P
V
R
W
S
P
P
E
V
L
M
----
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
-
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
379
Blastp_CBE
47.54
46%
-74
- C3 -
-
3MIY
6.9
-
B:
[9-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
---------
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
-----------
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
----------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
329
Blastp_CBE
47.52
47%
-41
- C3 -
-
2V7A
7.7
-
ABL1_HUMAN
B:
[8-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
-
T
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
317
Blastp_CBE
47.50
47%
-11
- C3 -
-
6NPV
11.4
-
ABL1_HUMAN
B:
[19-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
------------
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
------------------------
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
376
Blastp_CBE
47.39
46%
-77
- C3 -
-
4MF1
4.4
-
ITK_HUMAN
A:
[9-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
---------
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
----
A
--
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
---------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
321
Blastp_CBE
47.35
47%
-18
- C3 -
-
6NPE
10.9
-
ABL1_HUMAN
B:
[19-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
------------
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
---------------------------
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
238
Blastp_CBE
47.29
43%
2
- C3 -
-
4XEY
8.3
-
ABL1_HUMAN
A:
[116-382]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NY--------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
----
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
313
Blastp_CBE
47.07
47%
-8
- C3 -
-
3CS9
12.1
-
ABL1_HUMAN
B:
[10-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
----
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
----------------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
312
Blastp_CBE
47.07
47%
-7
- C3 -
-
3CS9
11.6
-
ABL1_HUMAN
C:
[10-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-----------
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
----------------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
378
Blastp_CBE
46.80
46%
-75
- C3 -
-
3MJ1
6.3
-
A:
[9-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
---------
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
--------------------
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
-----------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
-
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
323
Blastp_CBE
46.73
47%
-11
- C3 -
-
3PYY
11.3
-
ABL1_HUMAN
B:
[19-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
------------
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
------------------------
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
330
Blastp_CBE
46.70
47%
-34
- C3 -
-
2V7A
7.6
-
ABL1_HUMAN
A:
[7-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
E
D
T
--
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
-
T
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
279
Blastp_CBE
46.45
47%
-20
- C3 -
-
4WA9
8.4
-
ABL1_HUMAN
A:
[10-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
-----------------------------
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
----
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
T
Y
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
523
Blastp_CBE
46.23
43%
-42
- C3 -
-
6FNH
5.0
-
C:
[25-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
-
T
----GKKE
V
P
V
A
I
K
T
L
-
K
A
G
Y
--
T
---
E
K
Q
RV-
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
K
-
P
--
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
-
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
---------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
-
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
---------
281
Blastp_CBE
46.10
47%
-34
- C3 -
-
3DK7
8.1
-
ABL1_MOUSE
A:
[4-268]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-
K
---------
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
-
T
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
280
Blastp_CBE
46.00
47%
-40
- C3 -
-
3DK7
7.7
-
ABL1_MOUSE
B:
[4-268]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-------
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
-
T
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
309
Blastp_CBE
45.99
47%
-19
- C3 -
-
2HZ0
9.9
-
ABL1_HUMAN
B:
[6-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
------
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-------
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
---------------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
516
Blastp_CBE
45.83
43%
-33
- C3 -
-
6HEY
12.1
-
A:
[25-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
-
T
---
S
E---
V
P
V
A
I
K
T
L
-
K
A
G
Y
--
T
---
E
K
Q
RV-
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
K
-
P
--
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
-
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
-
S
----------------------
K
-
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
-
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
---------
472
Blastp_CBE
45.77
45%
-75
- C3 -
-
4QD6
5.0
-
ITK_HUMAN
A:
[9-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
---------
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
-----------
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
-
T
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
471
Blastp_CBE
45.77
45%
-78
- C3 -
-
4QD6
5.3
-
B:
[9-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
---------
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
------------
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
-
T
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
512
Blastp_CBE
45.33
43%
-37
- C3 -
-
6Q7E
11.3
-
?
A:
[25-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
-
T
----E---
V
P
V
A
I
K
T
L
-
K
A
G
Y
--
T
---
E
K
Q
RV-
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
K
-
P
--
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
-
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
---------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
-
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
---------
521
Blastp_CBE
45.23
43%
-36
- C3 -
-
6HET
10.8
-
A:
[25-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
-
T
----E---
V
P
V
A
I
K
T
L
-
K
A
G
Y
--
T
---
E
K
Q
RV-
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
K
-
P
--
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
-
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
---------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
-
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
---------
519
Blastp_CBE
45.23
43%
-29
- C3 -
-
6HEV
11.3
-
A:
[25-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-------KKE-
V
P
V
A
I
K
T
L
-
K
A
G
Y
--
T
---
E
K
Q
RV-
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
K
-
P
--
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
-
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
-
S
------------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
-
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
---------
478
Blastp_CBE
44.82
45%
-64
- C3 -
-
4PPA
5.5
-
ITK_HUMAN
A:
[9-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
---------
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
-------------
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
----------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
511
Blastp_CBE
44.76
43%
-36
- C3 -
-
6Q7F
10.4
-
?
A:
[25-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
-
T
----E---
V
P
V
A
I
K
T
L
-
K
A
G
Y
--
T
---
E
K
Q
RV-
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
K
-
P
--
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
-
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
----------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
-
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
---------
520
Blastp_CBE
44.61
43%
-19
- C3 -
-
6HEU
11.6
-
A:
[25-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
-
T
----KE--
V
P
V
A
I
K
T
L
-
K
A
G
Y
--
T
---
E
K
Q
RV-
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
K
-
P
--
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
-
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
-
S
-------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
-
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
---------
482
Blastp_CBE
44.58
45%
-69
- C3 -
-
4MF0
4.4
-
ITK_HUMAN
A:
[9-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
---------
Q
E
I
G
S
---
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
-------
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
-
T
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
246
Blastp_CBE
44.36
48%
-32
- C3 -
-
3DK6
5.7
-
ABL1_MOUSE
B:
[5-268]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
-------
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-----------
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
-
T
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
518
Blastp_CBE
44.34
43%
-23
- C3 -
-
6HEW
10.8
-
A:
[25-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-------KKE-
V
P
V
A
I
K
T
L
-
K
A
G
Y
--
T
---
E
K
Q
RV-
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
K
-
P
--
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
-
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
-
S
---------------------
G
K
-
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
-
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
---------
513
Blastp_CBE
44.28
43%
-19
- C3 -
-
6Q7D
11.9
-
?
A:
[25-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
-
T
----KE--
V
P
V
A
I
K
T
L
-
K
A
G
Y
--
T
---
E
K
Q
RV-
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
K
-
P
--
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
-
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
--------------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
-
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
---------
517
Blastp_CBE
44.22
43%
-27
- C3 -
-
6HEX
10.9
-
A:
[25-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-------KKE-
V
P
V
A
I
K
T
L
-
K
A
G
Y
--
T
---
E
K
Q
RV-
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
K
-
P
--
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
-
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
---------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
-
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
---------
475
Blastp_CBE
44.16
45%
-64
- C3 -
-
4PPB
5.7
-
B:
[9-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
---------
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
-------------
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
----------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
474
Blastp_CBE
44.07
45%
-68
- C3 -
-
4PPC
5.5
-
ITK_HUMAN
A:
[9-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
---------
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
-------------------
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
-----------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
473
Blastp_CBE
43.99
45%
-71
- C3 -
-
4PPC
5.3
-
B:
[9-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
---------
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
-------------------
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
----A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
-----------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
515
Blastp_CBE
43.93
43%
-11
- C3 -
-
6Q7B
11.8
-
?
A:
[25-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
-
T
----KE--
V
P
V
A
I
K
T
L
-
K
A
G
Y
--
T
---
E
K
Q
RV-
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
K
-
P
--
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
-
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
-
S
---------------------
G
K
-
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
-
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
---------
514
Blastp_CBE
43.91
43%
-9
- C3 -
-
6Q7C
12.0
-
?
A:
[23-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
-
T
----KE--
V
P
V
A
I
K
T
L
-
K
A
G
Y
--
T
---
E
K
Q
RV-
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
K
-
P
--
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
-
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
-
S
---------------------
G
K
-
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
-
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
---------
408
Blastp_CBE
43.88
44%
-14
- C3 -
-
3QGY
6.9
-
ITK_HUMAN
A:
[21-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
-
M
V
IDPSELTFV
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
-
K
E
G
S
--
M
---
S
E
D
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
----------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
247
Blastp_CBE
43.78
48%
-34
- C3 -
-
3DK6
7.8
-
ABL1_MOUSE
A:
[4-268]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
---------
H
K
L
--
G
Q
F
G
E
V
Y
E
G
V
W
K
-
K
Y--
S
----
L
T
V
A
V
K
T
L
-----------
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-
S
R
-
L
-
M
-
T
G
D
-
T
-
T
---
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
-
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
477
Blastp_CBE
43.73
45%
-67
- C3 -
-
4PPA
5.9
-
B:
[9-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
---------
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
-------------
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
----------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
510
Blastp_CBE
43.67
43%
-16
- C3 -
-
6Q7G
11.6
-
?
A:
[25-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
-
T
----KE--
V
P
V
A
I
K
T
L
-
K
A
G
Y
--
T
---
E
K
Q
RV-
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
K
-
P
--
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
-
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
---------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
-
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
---------
476
Blastp_CBE
43.63
45%
-66
- C3 -
-
4PPB
5.5
-
ITK_HUMAN
A:
[9-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
---------
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
-------------
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
----------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
522
Blastp_CBE
43.59
43%
-21
- C3 -
-
6HES
11.1
-
A:
[25-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-------KKE-
V
P
V
A
I
K
T
L
-
K
A
G
Y
--
T
---
E
K
Q
RV-
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
K
-
P
--
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
-
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
-
S
-------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
-
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
---------
481
Blastp_CBE
43.49
45%
-68
- C3 -
-
4MF0
4.9
-
B:
[9-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
---------
Q
E
I
G
S
---
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
-------
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
-----------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
407
Blastp_CBE
42.59
44%
-15
- C3 -
-
3QGY
5.2
-
B:
[22-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
IDPSELTFV
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
-
K
E
G
S
--
M
---
S
E
D
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
-
T
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
409
Blastp_CBE
41.87
44%
-13
- C3 -
-
3QGW
4.9
-
B:
[24-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IDPSELTFV
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
-
K
E
G
S
--
M
---
S
E
D
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
-----------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
410
Blastp_CBE
41.33
44%
-1
- C3 -
-
3QGW
6.3
-
ITK_HUMAN
A:
[24-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IDPSELTFV
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-
N
---
K
----
D
K
V
A
I
K
T
I
-
K
E
G
S
--
M
---
S
E
D
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
--
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
-
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
---------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
-
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------