@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Screening
Virtual Screening Score
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : BMR1A_HUMAN: (2020-09-05 )
MPQLYIYIRLLGAYLFIISRVQGQNLDSMLHGTGMKSDSDQKKSENGVTLAPEDTLPFLKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRRTIECCRTNLCNQYLQPTLPPVVIGPFFDGSIRWLVLLISMAVCIIAMIIFSSCFCYKHYCKSISSRRRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVESQDVKI
Atome Classification :
(167 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200...-....210.......220.......230.......240.......250...--.-...260----.....----...270.......280..---.....290.......300....-...310.......320..--.---....330------.......340.......---350.--..--..--...360.......370.......380..---....-.390--.........400...---....410..-.....420.--......430.......440..---...-..450.......460----------........470.......480...-....490........500.......510.......520.......530
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(pKd)
(pKd)
(Uniprot)
M
P
Q
L
Y
I
Y
I
R
L
L
G
A
Y
L
F
I
I
S
RVQGQ
N
L
D
S
M
L
HGTGMKSDSDQKKSENG
V
T
LAPEDT
L
P
F
L
K
C
Y
CSGHCPDDAINNTCITNG
H
C
F
A
I
I
EEDDQGE
T
T
L
A
S
G
C
MKYEGSDFQCKDS
P
K
A
Q
L
R
R
T
I
E
C
C
R
T
N
L
C
N
Q
Y
LQPTLP
P
V
V
I
GPFFDG
S
I
R
W
L
V
L
L
I
S
M
A
V
C
I
I
A
M
I
I
F
S
S
C
F
C
Y
K
H
Y
C
K
S
I
S
S
R
R
RYNRDLEQDEAFIPV
G
E
S
-
L
K
D
L
I
D
QSQSSGSGSG
L
P
L
L
V
Q
R
T
I
A
K
Q
I
Q
M
V
R
Q
VGKGRYGE
V
W
M
GKWRG--
E
-
K
V
A
V
K
-----
V
F
F
TT----EEA
S
W
F
R
E
T
E
I
Y
Q
T
V
L
M
R
---
H
E
N
I
L
G
F
I
A
ADIKGTGS
W
T
Q
L
Y
-
L
I
T
D
YHENG
S
L
Y
D
F
L
K
C
A--T---L
D
T
R
A
L
L
------
K
L
A
Y
S
AACGL
C
H
L
H
T
E
I
---YG-T--QG--KP--
A
I
AHRDLKSK
N
I
L
I
KKNG
S
C
C
I
ADL
G
L
A
---
V
K
FN-SD----TN
E
V
DVPLNTRVGTK---RYM
A
P
E
V
L
D
-
E
S
LNKNHFQ--
P
Y
I
M
A
D
I
Y
S
F
G
L
I
I
W
E
M
A
R
R
C
---ITG-G
I
V
E
E
YQLPYYNMV-----------PSDP
S
Y
E
D
M
R
E
V
V
C
V
K
R
L
R
P
I
V
SN-RW
N
S
D
E
-
C
L
R
A
V
L
K
L
M
S
E
C
WAH
N
P
A
S
R
L
T
A
L
R
I
K
K
T
L
A
K
M
V
E
SQDVKI
1
PsiBlast_PDB
93.61
85%
-109
- C1 -
-
3MDY
8.5
-
BMR1B_HUMAN
A:
[9-337]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
-
L
R
D
L
I
E
Q
S
Q
S
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
K
Q
I
Q
M
V
K
Q
I
G
K
G
R
Y
G
E
V
W
M
G
K
W
R
G
--
E
-
K
V
A
V
K
-----
V
F
F
T
T
----
E
E
A
S
W
F
R
E
T
E
I
Y
Q
T
V
L
M
R
---
H
E
N
I
L
G
F
I
A
A
D
I
K
G
T
G
S
W
T
Q
L
Y
-
L
I
T
D
Y
H
E
N
G
S
L
Y
D
Y
L
K
S
T
--
T
---
L
D
A
K
S
M
L
------
K
L
A
Y
S
S
V
S
G
L
C
H
L
H
T
E
I
---
F
S
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
---
V
K
F
I
--------------
P
N
T
R
V
G
T
K
---
R
Y
M
P
P
E
V
L
D
-
E
S
L
N
R
N
H
F
Q
--
S
Y
I
M
A
D
M
Y
S
F
G
L
I
L
W
E
V
A
R
R
C
---
V
S
G
-
G
I
V
E
E
Y
Q
L
P
Y
H
D
L
V
-----------
P
S
D
P
S
Y
E
D
M
R
E
I
V
C
I
K
K
L
R
P
S
F
P
N
-
R
W
S
S
D
E
-
C
L
R
Q
M
G
K
L
M
T
E
C
W
A
H
N
P
A
S
R
L
T
A
L
R
V
K
K
T
L
A
K
M
S
E
S
Q
D
I
K
L
21
Blastp_CBE
92.83
85%
-108
- C1 -
-
3MDY
8.5
-
BMR1B_HUMAN
C:
[9-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
-
L
R
D
L
I
E
Q
S
Q
S
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
K
Q
I
Q
M
V
K
Q
I
G
K
G
R
Y
G
E
V
W
M
G
K
W
R
G
--
E
-
K
V
A
V
K
-----
V
F
F
T
T
----
E
E
A
S
W
F
R
E
T
E
I
Y
Q
T
V
L
M
R
---
H
E
N
I
L
G
F
I
A
A
D
I
K
G
T
G
S
W
T
Q
L
Y
-
L
I
T
D
Y
H
E
N
G
S
L
Y
D
Y
L
K
S
T
--
T
---
L
D
A
K
S
M
L
------
K
L
A
Y
S
S
V
S
G
L
C
H
L
H
T
E
I
---
F
S
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
---
V
K
F
I
------------
I
P
P
N
T
R
V
G
T
K
---
R
Y
M
P
P
E
V
L
D
-
E
S
L
N
R
N
H
F
Q
--
S
Y
I
M
A
D
M
Y
S
F
G
L
I
L
W
E
V
A
R
R
C
---
V
S
G
-
G
I
V
E
E
Y
Q
L
P
Y
H
D
L
V
-----------
P
S
D
P
S
Y
E
D
M
R
E
I
V
C
I
K
K
L
R
P
S
F
P
N
-
R
W
S
S
D
E
-
C
L
R
Q
M
G
K
L
M
T
E
C
W
A
H
N
P
A
S
R
L
T
A
L
R
V
K
K
T
L
A
K
M
S
E
S
Q
D
I
--
31
Blastp_CBE
92.57
64%
-110
- C1 -
-
2X7O
-
-
TGFR1_HUMAN
D:
[10-339]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
G
T
T
-
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
-
E
V
A
V
K
-----
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
-
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
--
T
---
V
T
V
E
G
M
I
------
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
---
V
R
H
D
-
S
A
----
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
---
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
---
28
Blastp_CBE
92.53
64%
-121
- C1 -
-
3FAA
-
-
TGFR1_HUMAN
C:
[10-339]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
G
T
T
-
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
-
E
V
A
V
K
-----
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
-
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
--
T
---
V
T
V
E
G
M
I
------
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
---
V
R
H
D
-
S
A
----
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
---
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
---
30
Blastp_CBE
92.47
64%
-110
- C1 -
-
2X7O
-
-
TGFR1_HUMAN
E:
[10-339]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
G
T
T
-
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
-
E
V
A
V
K
-----
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
-
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
--
T
---
V
T
V
E
G
M
I
------
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
---
V
R
H
D
-
S
A
----
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
---
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
---
33
Blastp_CBE
92.46
64%
-110
- C1 -
-
2X7O
-
-
TGFR1_HUMAN
B:
[10-339]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
G
T
T
-
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
-
E
V
A
V
K
-----
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
-
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
--
T
---
V
T
V
E
G
M
I
------
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
---
V
R
H
D
-
S
A
----
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
---
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
---
29
Blastp_CBE
92.42
64%
-120
- C1 -
-
3FAA
-
-
TGFR1_HUMAN
B:
[10-340]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
G
T
T
-
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
-
E
V
A
V
K
-----
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
-
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
--
T
---
V
T
V
E
G
M
I
------
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
----------
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
---
V
R
H
D
-
S
A
----
T
D
T
I
D
I
---
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
---
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
I
--
32
Blastp_CBE
92.22
64%
-109
- C1 -
-
2X7O
-
-
TGFR1_HUMAN
C:
[10-339]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
G
T
T
-
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
-
E
V
A
V
K
-----
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
-
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
--
T
---
V
T
V
E
G
M
I
------
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
---
V
R
H
D
-
S
A
----
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
---
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
---
6
PsiBlast_PDB
92.06
63%
-109
- C1 -
-
2X7O
-
-
TGFR1_HUMAN
A:
[10-339]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
G
T
T
-
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
-
E
V
A
V
K
-----
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
-
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
--
T
---
V
T
V
E
G
M
I
------
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
---
V
R
H
D
-
S
A
----
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
---
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
---
26
Blastp_CBE
92.00
64%
-114
- C1 -
-
3FAA
-
-
TGFR1_HUMAN
E:
[10-339]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
G
T
T
-
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
-
E
V
A
V
K
-----
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
-
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
--
T
---
V
T
V
E
G
M
I
------
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
---
V
R
H
D
-
S
A
----
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
---
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
---
27
Blastp_CBE
91.71
64%
-114
- C1 -
-
3FAA
-
-
TGFR1_HUMAN
D:
[10-339]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
G
T
T
-
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
-
E
V
A
V
K
-----
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
-
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
--
T
---
V
T
V
E
G
M
I
------
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
---
V
R
H
D
-
S
A
----
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
---
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
---
22
Blastp_CBE
91.71
64%
-109
- C1 -
-
3KCF
-
-
TGFR1_HUMAN
E:
[10-339]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
G
T
T
-
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
-
E
V
A
V
K
-----
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
-
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
--
T
---
V
T
V
E
G
M
I
------
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
---
V
R
H
D
-
S
A
----
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
---
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
---
23
Blastp_CBE
91.41
64%
-115
- C1 -
-
3KCF
-
-
TGFR1_HUMAN
D:
[10-339]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
G
T
T
-
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
-
E
V
A
V
K
-----
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
-
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
--
T
---
V
T
V
E
G
M
I
------
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
---
V
R
H
D
-
S
A
----
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
---
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
---
4
PsiBlast_PDB
91.36
63%
-115
- C1 -
-
3FAA
-
-
TGFR1_HUMAN
A:
[10-339]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
G
T
T
-
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
-
E
V
A
V
K
-----
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
-
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
--
T
---
V
T
V
E
G
M
I
------
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
---
V
R
H
D
-
S
A
----
T
D
T
I
D
I
--
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
---
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
---
5
PsiBlast_PDB
91.33
63%
-112
- C1 -
-
3KCF
-
-
TGFR1_HUMAN
A:
[10-339]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
G
T
T
-
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
-
E
V
A
V
K
-----
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
-
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
--
T
---
V
T
V
E
G
M
I
------
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
---
V
R
H
D
-
S
A
----
T
D
T
I
D
I
--
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
---
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
---
3
PsiBlast_PDB
91.31
63%
-109
- C1 -
-
1IAS
-
-
TGFR1_HUMAN
A:
[10-339]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
G
T
T
-
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
-
E
V
A
V
K
-----
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
-
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
--
T
---
V
T
V
E
G
M
I
------
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
---
V
R
H
D
-
S
A
----
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
---
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
---
25
Blastp_CBE
91.26
64%
-113
- C1 -
-
3KCF
-
-
TGFR1_HUMAN
B:
[10-340]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
G
T
T
-
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
-
E
V
A
V
K
-----
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
-
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
--
T
---
V
T
V
E
G
M
I
------
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
----------
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
---
V
R
H
D
-
S
A
----
T
D
T
I
D
I
---
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
---
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
I
--
24
Blastp_CBE
91.12
64%
-112
- C1 -
-
3KCF
-
-
TGFR1_HUMAN
C:
[10-339]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
G
T
T
-
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
-
E
V
A
V
K
-----
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
-
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
--
T
---
V
T
V
E
G
M
I
------
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
---
V
R
H
D
-
S
A
----
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
---
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
---
449
HHSearch
90.46
86%
-114
- C1 -
-
3MDY
8.5
-
BMR1B_HUMAN
A:
[27-336]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
L
V
Q
R
T
I
A
K
Q
I
Q
M
V
K
Q
I
G
K
G
R
Y
G
E
V
W
M
G
K
W
R
G
--
E
-
K
V
A
V
K
-----
V
F
F
T
T
----
E
E
A
S
W
F
R
E
T
E
I
Y
Q
T
V
L
M
R
---
H
E
N
I
L
G
F
I
A
A
D
I
K
G
T
G
S
W
T
Q
L
Y
-
L
I
T
D
Y
H
E
N
G
S
L
Y
D
Y
L
K
S
T
--
T
---
L
D
A
K
S
M
L
------
K
L
A
Y
S
S
V
S
G
L
C
H
L
H
T
E
I
---
F
S
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
---
V
K
F
I
--------------
P
N
T
R
V
G
T
K
---
R
Y
M
P
P
E
V
L
D
-
E
S
L
N
R
N
H
F
Q
--
S
Y
I
M
A
D
M
Y
S
F
G
L
I
L
W
E
V
A
R
R
C
---
V
S
G
-
G
I
V
E
E
Y
Q
L
P
Y
H
D
L
V
-----------
P
S
D
P
S
Y
E
D
M
R
E
I
V
C
I
K
K
L
R
P
S
F
P
N
-
R
W
S
S
D
E
-
C
L
R
Q
M
G
K
L
M
T
E
C
W
A
H
N
P
A
S
R
L
T
A
L
R
V
K
K
T
L
A
K
M
S
E
S
Q
D
I
K
-
56
Blastp_CBE
89.49
63%
-123
- C1 -
-
5E8X
8.6
-
TGFR1_HUMAN
A:
[4-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
D
I
V
L
Q
E
S
V
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
-
E
V
A
V
K
-----
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
F
Q
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
-
L
V
T
D
F
H
E
H
G
N
L
F
D
Y
L
N
R
Y
--
T
---
V
T
V
E
G
M
I
------
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
C
D
F
G
L
A
---
V
R
H
D
-
S
A
----
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
---
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
I
K
M
451
HHSearch
88.86
63%
-123
- C1 -
-
5E8X
8.6
-
TGFR1_HUMAN
A:
[5-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
R
D
I
V
L
Q
E
S
V
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
-
E
V
A
V
K
-----
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
F
Q
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
-
L
V
T
D
F
H
E
H
G
N
L
F
D
Y
L
N
R
Y
--
T
---
V
T
V
E
G
M
I
------
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
C
D
F
G
L
A
---
V
R
H
D
-
S
A
----
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
---
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
I
K
-
453
HHSearch
87.21
65%
-120
- C1 -
-
5USQ
9.0
-
TGFR1_HUMAN
A:
[2-298]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
-
E
V
A
V
K
-----
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
-
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
--
T
---
V
T
V
E
G
M
I
------
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
---
V
R
H
D
-
S
A
----
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
---
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
------
8
PsiBlast_PDB
87.19
63%
-104
- C1 -
-
6EIX
7.1
-
ACVR1_HUMAN
A:
[23-334]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
S
G
L
P
F
L
V
Q
R
T
V
A
R
E
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
-
N
V
A
V
K
-----
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
-
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
--
T
---
L
D
T
V
S
C
L
------
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---
F
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
---
V
M
H
S
-
Q
S
----
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
---
V
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
D
N
S
L
D
---
54
Blastp_CBE
87.05
66%
-120
- C1 -
-
5USQ
9.0
-
TGFR1_HUMAN
A:
[1-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
-
E
V
A
V
K
-----
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
-
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
--
T
---
V
T
V
E
G
M
I
------
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
---
V
R
H
D
-
S
A
----
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
---
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
--------
13
PsiBlast_PDB
86.96
64%
-119
- C1 -
-
2WOU
6.1
-
TGFR1_HUMAN
A:
[3-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
-
E
V
A
V
K
-----
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
-
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
--
T
---
V
T
V
E
G
M
I
------
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
---
V
R
H
D
-
S
A
----
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
---
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
-------
12
PsiBlast_PDB
86.94
64%
-113
- C1 -
-
2WOT
9.2
-
TGFR1_HUMAN
A:
[3-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
-
E
V
A
V
K
-----
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
-
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
--
T
---
V
T
V
E
G
M
I
------
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
---
V
R
H
D
-
S
A
----
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
---
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
---
42
Blastp_CBE
86.89
64%
-111
- C1 -
-
6B8Y
8.9
-
TGFR1_HUMAN
A:
[4-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
D
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
-
E
V
A
V
K
-----
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
-
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
--
T
---
V
T
V
E
G
M
I
------
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
---
V
R
H
D
-
S
A
----
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
---
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
I
--
51
Blastp_CBE
86.86
64%
-114
- C1 -
-
1VJY
7.2
-
TGFR1_HUMAN
A:
[1-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
-
E
V
A
V
K
-----
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
-
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
--
T
---
V
T
V
E
G
M
I
------
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
---
V
R
H
D
-
S
A
----
T
D
T
I
D
I
----
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
---
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
I
K
M
46
Blastp_CBE
86.77
64%
-110
- C1 -
-
5E8W
9.0
-
TGFR1_HUMAN
A:
[4-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
D
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
-
E
V
A
V
K
-----
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
-
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
--
T
---
V
T
V
E
G
M
I
------
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
---
V
R
H
D
-
S
A
----
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
---
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
I
--
17
PsiBlast_PDB
86.65
64%
-116
- C1 -
-
4X2F
4.4
-
TGFR1_HUMAN
A:
[2-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
-
E
V
A
V
K
-----
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
-
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
--
T
---
V
T
V
E
G
M
I
------
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
---
V
R
H
D
-
S
A
----
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
---
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
I
--
16
PsiBlast_PDB
86.50
64%
-115
- C1 -
-
4X2G
3.9
-
TGFR1_HUMAN
A:
[2-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
-
E
V
A
V
K
-----
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
-
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
--
T
---
V
T
V
E
G
M
I
------
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
---
V
R
H
D
-
S
A
----
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
---
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
I
--
15
PsiBlast_PDB
86.49
64%
-114
- C1 -
-
5QIM
7.6
-
TGFR1_HUMAN
A:
[3-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
-
E
V
A
V
K
-----
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
-
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
--
T
---
V
T
V
E
G
M
I
------
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
---
V
R
H
D
-
S
A
----
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
---
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
I
--
43
Blastp_CBE
86.48
64%
-110
- C1 -
-
5QIL
7.3
-
TGFR1_HUMAN
A:
[4-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
D
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
-
E
V
A
V
K
-----
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
-
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
--
T
---
V
T
V
E
G
M
I
------
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
---
V
R
H
D
-
S
A
----
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
---
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
----
53
Blastp_CBE
86.33
66%
-115
- C1 -
-
5FRI
6.3
-
TGFR1_HUMAN
A:
[3-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
-
E
V
A
V
K
-----
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
-
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
--
T
---
V
T
V
E
G
M
I
------
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
---
V
R
H
D
-
S
A
----
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
---
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
--------
48
Blastp_CBE
86.27
64%
-118
- C1 -
-
3TZM
7.6
-
TGFR1_HUMAN
A:
[6-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
-
E
V
A
V
K
-----
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
-
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
--
T
---
V
T
V
E
G
M
I
------
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
---
V
R
H
D
-
S
A
----
T
D
T
I
D
I
A
P
--
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
---
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
-------
20
PsiBlast_PDB
85.92
64%
-112
- C1 -
-
4X2K
5.6
-
TGFR1_HUMAN
A:
[2-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
-
E
V
A
V
K
-----
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
-
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
--
T
---
V
T
V
E
G
M
I
------
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
---
V
R
H
D
-
S
A
----
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
---
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
I
--
19
PsiBlast_PDB
85.92
64%
-112
- C1 -
-
4X2J
5.6
-
TGFR1_HUMAN
A:
[2-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
-
E
V
A
V
K
-----
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
-
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
--
T
---
V
T
V
E
G
M
I
------
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
---
V
R
H
D
-
S
A
----
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
---
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
I
--
18
PsiBlast_PDB
85.78
64%
-115
- C1 -
-
4X0M
3.2
-
TGFR1_HUMAN
A:
[2-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
-
E
V
A
V
K
-----
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
-
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
--
T
---
V
T
V
E
G
M
I
------
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
---
V
R
H
D
-
S
A
----
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
---
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
I
--
454
HHSearch
85.73
64%
-113
- C1 -
-
4X2J
5.6
-
TGFR1_HUMAN
A:
[3-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
-
E
V
A
V
K
-----
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
-
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
--
T
---
V
T
V
E
G
M
I
------
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
---
V
R
H
D
-
S
A
----
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
---
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
I
--
45
Blastp_CBE
85.60
64%
-108
- C1 -
-
5E8Z
6.8
-
TGFR1_HUMAN
A:
[4-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
D
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
-
E
V
A
V
K
-----
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
-
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
--
T
---
V
T
V
E
G
M
I
------
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
---
V
R
H
D
-
S
A
----
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
---
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
----
44
Blastp_CBE
85.36
64%
-108
- C1 -
-
5QIK
8.0
-
TGFR1_HUMAN
A:
[4-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
D
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
-
E
V
A
V
K
-----
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
-
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
--
T
---
V
T
V
E
G
M
I
------
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
---
V
R
H
D
-
S
A
----
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
---
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
----
90
Blastp_CBE
85.31
63%
-115
- C1 -
-
3Q4U
8.8
-
ACVR1_HUMAN
B:
[2-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
Q
R
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
-
N
V
A
V
K
-----
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
-
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
--
T
---
L
D
T
V
S
C
L
------
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---
F
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
---
V
M
H
S
-
Q
S
----
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
---
V
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
--------
49
Blastp_CBE
84.99
64%
-116
- C1 -
-
3HMM
8.1
-
TGFR1_HUMAN
A:
[1-298]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
-
E
V
A
V
K
-----
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
-
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
--
T
---
V
T
V
E
G
M
I
------
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
---
V
R
H
D
-
S
A
----
T
D
T
I
D
I
A
-----
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
---
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
-----
55
Blastp_CBE
84.96
63%
-109
- C1 -
-
5E90
7.1
-
TGFR1_HUMAN
A:
[4-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
D
I
V
L
Q
E
S
V
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
-
E
V
A
V
K
-----
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
F
Q
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
-
L
V
T
D
F
H
E
H
G
N
L
F
D
Y
L
N
R
Y
--
T
---
V
T
V
E
G
M
I
------
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
C
D
F
G
L
A
---
V
R
H
D
-
S
A
----
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
---
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
----
52
Blastp_CBE
84.89
65%
-115
- C1 -
-
1RW8
7.3
-
TGFR1_HUMAN
A:
[1-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
-
E
V
A
V
K
-----
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
-
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
--
T
---
V
T
V
E
G
M
I
------
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
---
V
R
H
D
-
S
A
----
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
---
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
----
47
Blastp_CBE
84.48
64%
-106
- C1 -
-
5E8T
2.5
-
TGFR1_HUMAN
A:
[4-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
D
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
-
E
V
A
V
K
-----
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
-
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
--
T
---
V
T
V
E
G
M
I
------
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
---
V
R
H
D
-
S
A
----
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
---
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
----
67
Blastp_CBE
83.61
63%
-117
- C1 -
-
6T6D
7.5
-
?
A:
[6-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
-
N
V
A
V
K
-----
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
-
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
--
T
---
L
D
T
V
S
C
L
------
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---
F
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
---
V
M
H
S
-
Q
S
----
T
N
-
L
D
V
---
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
---
V
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
--------
60
Blastp_CBE
83.41
64%
-111
- C1 -
-
4DYM
6.5
-
ACVR1_HUMAN
A:
[9-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
-
N
V
A
V
K
-----
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
-
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
--
T
---
L
D
T
V
S
C
L
------
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---
F
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
---
V
M
H
S
-
Q
S
----
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
---
V
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
--------
59
Blastp_CBE
83.38
64%
-112
- C1 -
-
6ACR
7.0
-
ACVR1_HUMAN
A:
[5-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
H
Q
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
-
N
V
A
V
K
-----
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
-
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
--
T
---
L
D
T
V
S
C
L
------
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---
F
G
-----
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
---
V
M
H
S
-
Q
S
----
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
---
V
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
--------
86
Blastp_CBE
83.37
63%
-109
- C1 -
-
4BGG
8.2
-
ACVR1_HUMAN
B:
[5-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
-
N
V
A
V
K
-----
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
-
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
--
T
---
L
D
T
V
S
C
L
------
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---
F
------
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
---
V
M
H
S
-
Q
S
----
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
---
V
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
--------
94
Blastp_CBE
83.21
63%
-110
- C1 -
-
3MTF
7.5
-
ACVR1_HUMAN
A:
[5-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
-
N
V
A
V
K
-----
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
-
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
--
T
---
L
D
T
V
S
C
L
------
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---
F
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
---
V
M
H
S
-
Q
S
----
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
---
V
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
--------
66
Blastp_CBE
83.19
63%
-109
- C1 -
-
6T6D
7.2
-
?
B:
[5-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
-
N
V
A
V
K
-----
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
-
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
--
T
---
L
D
T
V
S
C
L
------
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---
F
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
---
V
M
H
S
-
Q
S
----
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
---
V
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
--------
81
Blastp_CBE
83.10
63%
-108
- C1 -
-
5OXG
8.5
-
ACVR1_HUMAN
C:
[2-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
Q
R
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
-
N
V
A
V
K
-----
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
-
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
--
T
---
L
D
T
V
S
C
L
------
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---
F
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
---
V
M
H
S
-
Q
S
----
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
---
V
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
--------
74
Blastp_CBE
83.02
63%
-113
- C1 -
-
6GIN
8.7
-
ACVR1_HUMAN
A:
[6-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
-
N
V
A
V
K
-----
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
-
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
--
T
---
L
D
T
V
S
C
L
------
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---
F
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
---
V
M
H
S
-
Q
S
----
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
---
V
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
--------
50
Blastp_CBE
82.98
64%
-114
- C1 -
-
3GXL
8.0
-
TGFR1_HUMAN
A:
[1-298]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
------
E
V
A
V
K
-----
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
-
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
--
T
---
V
T
V
E
G
M
I
------
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
---
V
R
H
D
-
S
A
----
T
D
T
I
D
-----
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
---
S
----
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
-
R
--
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
-----
7
PsiBlast_PDB
82.77
65%
-108
- C1 -
-
1PY5
6.2
-
TGFR1_HUMAN
A:
[26-325]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
-
E
V
A
V
K
-----
I
F
S
S
R
----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
-
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
--
T
---
V
T
V
E
G
M
I
------
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
---
V
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
---
V
R
H
D
-
S
A
----
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
D
S
I
N
M
K
H
F
E
--
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
---
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
-----------
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
-
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
----
78
Blastp_CBE
82.76
63%
-113
- C1 -
-
5OY6
6.9
-
ACVR1_HUMAN
B:
[5-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
-
N
V
A
V
K
-----
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
-
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
--
T
---
L
D
T
V
S
C
L
------
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---
F
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
---
V
M
H
S
---------
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
---
V
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
--------
91
Blastp_CBE
82.73
63%
-110
- C1 -
-
3Q4U
8.6
-
ACVR1_HUMAN
A:
[4-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
-
N
V
A
V
K
-----
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
-
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
--
T
---
L
D
T
V
S
C
L
------
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---
F
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
---
V
M
H
S
-
Q
S
----
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
---
V
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
--------
87
Blastp_CBE
82.72
63%
-108
- C1 -
-
4BGG
8.0
-
ACVR1_HUMAN
A:
[5-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
-
N
V
A
V
K
-----
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
-
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
--
T
---
L
D
T
V
S
C
L
------
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---
F
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
---
V
M
H
S
-
Q
S
----
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
---
V
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
--------
76
Blastp_CBE
82.63
63%
-111
- C1 -
-
5OY6
7.2
-
ACVR1_HUMAN
D:
[6-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
-
N
V
A
V
K
-----
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
-
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
--
T
---
L
D
T
V
S
C
L
------
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---
F
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
---
V
M
H
S
---------
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
---
V
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
--------
82
Blastp_CBE
82.47
63%
-107
- C1 -
-
5OXG
8.5
-
ACVR1_HUMAN
B:
[5-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
-
N
V
A
V
K
-----
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
-
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
--
T
---
L
D
T
V
S
C
L
------
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---
F
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
---
V
M
H
S
-
Q
S
----
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
---
V
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
--------
455
HHSearch
82.46
63%
-108
- C1 -
-
5OXG
8.5
-
ACVR1_HUMAN
C:
[5-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
-
N
V
A
V
K
-----
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
-
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
--
T
---
L
D
T
V
S
C
L
------
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---
F
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
---
V
M
H
S
-
Q
S
----
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
---
V
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
--------
92
Blastp_CBE
82.27
63%
-110
- C1 -
-
3OOM
7.5
-
ACVR1_HUMAN
A:
[5-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
-
N
V
A
V
K
-----
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
-
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
--
T
---
L
D
T
V
S
C
L
------
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---
F
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
---
V
M
H
S
-
Q
S
----
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
---
V
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
--------
73
Blastp_CBE
82.27
63%
-112
- C1 -
-
6GIN
8.1
-
ACVR1_HUMAN
B:
[6-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
-
N
V
A
V
K
-----
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
-
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
--
T
---
L
D
T
V
S
C
L
------
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---
F
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
---
V
M
H
S
-
Q
S
----
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
---
V
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
--------
77
Blastp_CBE
82.24
63%
-112
- C1 -
-
5OY6
7.2
-
ACVR1_HUMAN
C:
[6-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
-
N
V
A
V
K
-----
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
-
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
--
T
---
L
D
T
V
S
C
L
------
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---
F
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
---
V
M
H
S
---------
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
---
V
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
--------
58
Blastp_CBE
82.12
64%
-109
- C1 -
-
6ACR
7.3
-
ACVR1_HUMAN
B:
[5-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
H
Q
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
-
N
V
A
V
K
-----
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
-
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
--
T
---
L
D
T
V
S
C
L
------
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---
F
------
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
---
V
M
H
S
-
Q
S
----
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
---
V
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
--------
89
Blastp_CBE
82.11
63%
-108
- C1 -
-
3Q4U
8.9
-
ACVR1_HUMAN
C:
[6-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
-
N
V
A
V
K
-----
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
-
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
--
T
---
L
D
T
V
S
C
L
------
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---
F
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
---
V
M
H
S
-
Q
S
----
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
---
V
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
--------
75
Blastp_CBE
82.07
63%
-111
- C1 -
-
6GI6
6.7
-
ACVR1_HUMAN
A:
[4-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
-
N
V
A
V
K
-----
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
-
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
--
T
---
L
D
T
V
S
C
L
------
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---
F
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
---
V
M
H
S
-
Q
S
----
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
---
V
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
--------
61
Blastp_CBE
82.04
63%
-109
- C1 -
-
6TN8
6.0
-
?
A:
[6-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
-
N
V
A
V
K
-----
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
-
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
--
T
---
L
D
T
V
S
C
L
------
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---
F
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
---
V
M
H
S
-
Q
S
----
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
---
V
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
--------
79
Blastp_CBE
81.82
63%
-108
- C1 -
-
5OY6
6.4
-
ACVR1_HUMAN
A:
[6-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
-
N
V
A
V
K
-----
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
-
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
--
T
---
L
D
T
V
S
C
L
------
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---
F
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
---
V
M
H
S
---------
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
---
V
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
--------
70
Blastp_CBE
81.76
63%
-112
- C1 -
-
6SRH
8.1
-
ACVR1_HUMAN
B:
[7-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
-
N
V
A
V
K
-----
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
-
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
--
T
---
L
D
T
V
S
C
L
------
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---
F
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
---
V
M
H
S
-
Q
S
----
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
---
V
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
--------
65
Blastp_CBE
81.73
63%
-117
- C1 -
-
6T6D
7.6
-
?
C:
[7-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
-
N
V
A
V
K
-----
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
-
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
--
T
---
L
D
T
V
S
C
L
------
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-------------
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
---
V
M
H
S
----------------
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
---
V
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
--------
68
Blastp_CBE
81.57
63%
-109
- C1 -
-
6SZM
7.8
-
?
B:
[7-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
-
N
V
A
V
K
-----
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
-
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
--
T
---
L
D
T
V
S
C
L
------
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---
F
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
---
V
M
H
S
-
Q
S
----
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
---
V
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
--------
72
Blastp_CBE
81.51
63%
-109
- C1 -
-
6GIP
7.6
-
ACVR1_HUMAN
A:
[6-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
-
N
V
A
V
K
-----
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
-
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
--
T
---
L
D
T
V
S
C
L
------
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---
F
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
---
V
M
H
S
-
Q
S
----
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
---
V
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
--------
69
Blastp_CBE
81.50
63%
-117
- C1 -
-
6SZM
7.7
-
?
A:
[4-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
-
N
V
A
V
K
-----
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
-
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
--
T
---
L
D
T
V
S
C
L
------
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---
F
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
---
V
M
H
S
---------------
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
---
V
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
--------
83
Blastp_CBE
81.42
63%
-110
- C1 -
-
5OXG
8.4
-
ACVR1_HUMAN
A:
[5-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
-
N
V
A
V
K
-----
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
S
D
M
T
S
---
S
T
Q
L
W
-
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
--
T
---
L
D
T
V
S
C
L
------
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---
F
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
---
V
M
H
S
-
Q
S
----
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
---
V
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
--------
64
Blastp_CBE
81.41
63%
-114
- C1 -
-
6T6D
6.0
-
?
D:
[5-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
-
N
V
A
V
K
-----
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
-
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
--
T
---
L
D
T
V
S
C
L
------
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---
F
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
---
V
M
H
S
-
Q
---------------
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
---
V
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
--------
63
Blastp_CBE
81.25
63%
-109
- C1 -
-
6T8N
8.0
-
?
A:
[5-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
-
N
V
A
V
K
-----
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
S
D
M
T
S
---
S
T
Q
L
W
-
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
--
T
---
L
D
T
V
S
C
L
------
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---
F
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
---
V
M
H
S
-
Q
S
----
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
---
V
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
--------
80
Blastp_CBE
81.08
63%
-109
- C1 -
-
5OXG
8.5
-
ACVR1_HUMAN
D:
[6-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
-
N
V
A
V
K
-----
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
S
D
M
T
---
S
S
T
Q
L
W
-
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
--
T
---
L
D
T
V
S
C
L
------
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---
F
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
---
V
M
H
S
-
Q
S
----
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
---
V
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
--------
71
Blastp_CBE
81.00
63%
-116
- C1 -
-
6SRH
8.2
-
ACVR1_HUMAN
A:
[3-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
R
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
-
N
V
A
V
K
-----
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
-
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
--
T
---
L
D
T
V
S
C
L
------
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---
F
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
---
V
M
H
S
----------------
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
---
V
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
--------
84
Blastp_CBE
80.88
63%
-110
- C1 -
-
4BGG
8.1
-
ACVR1_HUMAN
D:
[6-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
-
N
V
A
V
K
-----
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
S
D
M
------
T
Q
L
W
-
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
--
T
---
L
D
T
V
S
C
L
------
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---
F
------
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
---
V
M
H
S
-
Q
S
----
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
---
V
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
--------
62
Blastp_CBE
80.87
63%
-107
- C1 -
-
6T8N
8.6
-
?
B:
[5-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
-
N
V
A
V
K
-----
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
S
D
M
T
S
----
T
Q
L
W
-
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
--
T
---
L
D
T
V
S
C
L
------
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---
F
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
---
V
M
H
S
-
Q
S
----
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
---
V
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
--------
456
HHSearch
80.85
63%
-116
- C1 -
-
6SRH
8.2
-
ACVR1_HUMAN
A:
[5-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
-
N
V
A
V
K
-----
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
-
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
--
T
---
L
D
T
V
S
C
L
------
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---
F
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
---
V
M
H
S
----------------
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
---
V
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
--------
85
Blastp_CBE
80.35
63%
-110
- C1 -
-
4BGG
8.1
-
ACVR1_HUMAN
C:
[6-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
-
N
V
A
V
K
-----
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
-
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
--
T
---
L
D
T
V
S
C
L
------
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
----------
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
---
V
M
H
S
-
Q
S
----
T
N
---
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
------------
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
---------
10
PsiBlast_PDB
75.37
64%
-38
- C1 -
-
4C02
7.1
-
ACVR1_HUMAN
A:
[9-329]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
L
A
D
L
L
D
----
S
G
S
G
S
G
L
P
F
L
V
Q
R
T
V
A
R
Q
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
-
N
V
A
V
K
-----
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
--
S
T
Q
L
W
-
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
--
T
---
L
D
T
V
S
C
L
------
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---
F
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
---
V
M
H
S
-
Q
S
----
T
N
Q
L
D
V
---
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
---
V
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
--------
11
PsiBlast_PDB
75.15
64%
-39
- C1 -
-
6I1S
7.8
-
ACVR1_HUMAN (first)
A:
[6-329]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
D
S
T
L
A
D
L
L
D
H
-----
S
G
S
G
L
P
F
L
V
Q
R
T
V
A
R
Q
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
-
N
V
A
V
K
-----
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
S
D
M
T
---
S
S
T
Q
L
W
-
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
--
T
---
L
D
T
V
S
C
L
------
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---
F
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
---
V
M
H
S
-
Q
S
----
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
---
V
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
--------
9
PsiBlast_PDB
74.69
64%
-40
- C1 -
-
3H9R
7.8
-
ACVR1_HUMAN
A:
[6-329]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
D
S
T
L
A
D
L
L
D
H
S
C
T
S
G
S
G
S
G
L
P
F
L
V
Q
R
T
V
A
R
Q
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
-
N
V
A
V
K
-----
I
F
S
S
R
----
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
---
H
E
N
I
L
G
F
I
A
S
D
M
T
---
S
S
T
Q
L
W
-
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
--
T
---
L
D
T
V
S
C
L
------
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
---
F
G
-
T
--
Q
G
--
K
P
--
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
---
V
M
H
------------------
R
V
G
T
K
---
R
Y
M
A
P
E
V
L
D
-
E
T
I
Q
V
D
C
F
D
--
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
---
V
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
-----------
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
-
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
--------
127
Blastp_CBE
64.55
36%
-36
- C1 -
-
5E92
7.7
-
TGFR2_HUMAN
A:
[11-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
L
D
T
L
V
G
K
G
R
F
A
E
V
Y
K
A
K
L
K
-F-
E
-
T
V
A
V
K
-----
I
F
P
Y
E
----
E
Y
A
S
W
K
T
E
K
D
I
F
S
D
I
N
L
K
---
H
E
N
I
L
Q
F
L
T
A
E
E
R
K
T
E
L
G
K
Q
Y
W
-
L
I
T
A
F
H
A
K
G
N
L
Q
E
Y
L
T
R
H
--
V
---
I
S
W
E
D
L
R
------
K
L
G
S
S
L
A
R
G
I
A
H
L
H
S
D
----
H
T
-
P
--
C
G
--
R
P
KM
P
I
V
H
R
D
L
K
S
S
N
I
L
V
K
N
D
L
T
C
C
L
C
D
F
G
L
S
---
L
R
L
D
-
P
T
----
L
S
V
D
D
L
A
N
S
G
Q
V
G
T
A
---
R
Y
M
A
P
E
V
L
A
-
S
A
M
N
L
E
N
V
E
--
S
F
K
Q
T
D
V
Y
S
M
A
L
V
L
W
E
M
T
S
R
C
---
N
A
V
-
G
E
V
K
D
Y
E
P
P
F
G
S
K
V
-----------
R
E
H
P
C
V
A
S
M
A
D
N
V
L
A
D
A
G
R
P
E
I
P
S
-
F
W
L
N
H
Q
-
G
I
Q
M
V
C
E
T
L
T
E
C
W
D
H
D
P
E
A
R
L
T
A
Q
C
V
A
E
R
F
S
E
L
--------
464
HHSearch
64.36
40%
-53
- C1 -
-
4ASX
5.4
-
AVR2A_HUMAN
A:
[23-320]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
P
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
--
E
-
Y
V
A
V
K
-----
I
F
P
I
Q
----
D
K
Q
S
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
---
H
E
N
I
L
Q
F
I
G
A
E
K
R
G
T
S
V
D
V
D
L
W
-
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
A
N
--
V
---
V
S
W
N
E
L
C
------
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
---
P
G
-
L
KD
G
H
--
K
P
--
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
---
L
K
F
E
-
A
G
----
K
S
A
--
G
-
T
H
G
Q
V
G
T
R
---
R
Y
M
A
P
E
V
L
E
-
G
A
I
N
F
Q
-
R
D
--
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
--------------
T
A
A
D
G
P
V
DEYMLPFEEEI
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
-
Y
W
Q
K
H
A
-
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
L
T
----
457
HHSearch
62.81
35%
-18
- C1 -
-
5E8Y
8.6
-
TGFR2_HUMAN
A:
[8-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
P
I
E
L
D
T
L
V
G
K
G
R
F
A
E
V
Y
K
A
K
L
K
Q
QF
E
-
T
V
A
V
K
-----
I
F
P
Y
E
----
E
Y
A
S
W
K
T
E
K
D
I
F
S
D
I
N
L
K
---
H
E
N
I
L
Q
F
L
T
A
E
E
R
K
T
E
L
G
K
Q
Y
W
-
L
I
T
A
F
H
A
K
G
N
L
Q
E
Y
L
T
R
H
--
V
---
I
S
W
E
D
L
R
------
K
L
G
S
S
L
A
R
G
I
A
H
L
H
S
D
H
---
T
P
C
G
--
R
P
--
K
M
--
P
I
V
H
R
D
L
K
S
S
N
I
L
V
K
N
D
L
T
C
C
L
C
D
F
G
L
S
---
L
R
L
D
-
P
T
----
L
S
V
D
D
L
A
N
S
G
Q
V
G
T
A
---
R
Y
M
A
P
E
V
L
A
-
S
A
M
N
L
E
N
V
E
--
S
F
K
Q
T
D
V
Y
S
M
A
L
V
L
W
E
M
T
S
R
C
---
N
A
V
-
G
E
V
K
D
Y
E
P
P
F
G
S
K
V
-----------
R
E
H
P
C
V
A
S
M
A
D
N
V
L
A
D
A
G
R
P
E
I
P
S
-
F
W
L
N
H
Q
-
G
I
Q
M
V
C
E
T
L
T
E
C
W
D
H
D
P
E
A
R
L
T
A
Q
C
V
A
E
R
F
S
E
L
--------
465
HHSearch
62.69
40%
-50
- C1 -
-
3SOC
7.1
-
AVR2A_HUMAN
A:
[23-320]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
P
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
--
E
-
Y
V
A
V
K
-----
I
F
P
I
Q
----
D
K
Q
S
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
---
H
E
N
I
L
Q
F
I
G
A
E
K
R
G
T
S
V
D
V
D
L
W
-
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
A
N
--
V
---
V
S
W
N
E
L
C
------
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
---
P
G
-
L
KD
G
H
--
K
P
--
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
---
L
K
F
E
-
A
G
----
K
S
A
--
G
D
T
H
G
Q
V
G
T
R
---
R
Y
M
A
P
E
V
L
E
-
G
A
I
N
F
Q
-
R
D
--
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
--------------
T
A
A
D
G
P
V
DEYMLPFEEEI
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
-
Y
W
Q
K
H
A
-
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
L
T
----
120
Blastp_CBE
62.61
42%
-31
- C1 -
-
4ASX
5.4
-
AVR2A_HUMAN
A:
[26-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
--
E
-
Y
V
A
V
K
-----
I
F
P
I
Q
----
D
K
Q
S
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
---
H
E
N
I
L
Q
F
I
G
A
E
K
R
G
T
S
V
D
V
D
L
W
-
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
A
N
--
V
---
V
S
W
N
E
L
C
------
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
---
P
G
-
L
--
K
D
GH
K
P
--
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
---
L
K
F
E
-
A
G
----
K
S
A
G
-
T
--
H
G
Q
V
G
T
R
---
R
Y
M
A
P
E
V
L
E
-
G
A
I
N
---
F
Q
RD
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
---
T
A
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
-----------
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
-
Y
W
Q
K
H
A
-
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
--------
128
Blastp_CBE
62.45
36%
-24
- C1 -
-
5E91
6.5
-
TGFR2_HUMAN
A:
[11-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
L
D
T
L
V
G
K
G
R
F
A
E
V
Y
K
A
K
L
K
---
E
-
T
V
A
V
K
-----
I
F
P
Y
E
----
E
Y
A
S
W
K
T
E
K
D
I
F
S
D
I
N
L
K
---
H
E
N
I
L
Q
F
L
T
A
E
E
R
K
T
E
L
G
K
Q
Y
W
-
L
I
T
A
F
H
A
K
G
N
L
Q
E
Y
L
T
R
H
--
V
---
I
S
W
E
D
L
R
------
K
L
G
S
S
L
A
R
G
I
A
H
L
H
S
D
----
H
T
-
P
--
C
G
--
R
P
KM
P
I
V
H
R
D
L
K
S
S
N
I
L
V
K
N
D
L
T
C
C
L
C
D
F
G
L
S
---
L
R
L
D
-
P
T
----
L
S
V
D
D
L
A
N
S
G
Q
V
G
T
A
---
R
Y
M
A
P
E
V
L
A
-
S
A
M
N
L
E
N
V
E
--
S
F
K
Q
T
D
V
Y
S
M
A
L
V
L
W
E
M
T
S
R
C
---
N
A
V
-
G
E
V
K
D
Y
E
P
P
F
G
S
K
V
-----------
R
E
H
P
C
V
A
S
M
A
D
N
V
L
A
D
A
G
R
P
E
I
P
S
-
F
W
L
N
H
Q
-
G
I
Q
M
V
C
E
T
L
T
E
C
W
D
H
D
P
E
A
R
L
T
A
Q
C
V
A
E
R
F
S
E
L
--------
121
Blastp_CBE
62.19
42%
-32
- C1 -
-
3SOC
7.2
-
AVR2A_HUMAN
B:
[26-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
--
E
-
Y
V
A
V
K
-----
I
F
P
I
Q
----
D
K
Q
S
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
---
H
E
N
I
L
Q
F
I
G
A
E
K
R
G
T
S
V
D
V
D
L
W
-
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
A
N
--
V
---
V
S
W
N
E
L
C
------
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
---
P
G
-
L
--
K
D
GH
K
P
--
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
---
L
K
F
E
-
A
G
----
K
S
A
--
T
--
H
G
Q
V
G
T
R
---
R
Y
M
A
P
E
V
L
E
-
G
A
I
N
---
F
Q
RD
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
---
T
A
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
-----------
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
-
Y
W
Q
K
H
A
-
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
--------
123
Blastp_CBE
61.76
42%
-30
- C1 -
-
3Q4T
7.0
-
AVR2A_HUMAN
B:
[26-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
--
E
-
Y
V
A
V
K
-----
I
F
P
I
Q
----
D
K
Q
S
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
---
H
E
N
I
L
Q
F
I
G
A
E
K
R
G
T
S
V
D
V
D
L
W
-
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
A
N
--
V
---
V
S
W
N
E
L
C
------
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
---
P
G
-
L
--
K
D
GH
K
P
--
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
---
L
K
F
E
-
A
G
----
K
S
A
--
T
--
H
G
Q
V
G
T
R
---
R
Y
M
A
P
E
V
L
E
-
G
A
I
N
---
F
Q
RD
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
---
T
A
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
-----------
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
-
Y
W
Q
K
H
A
-
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
--------
459
HHSearch
61.17
35%
-14
- C1 -
-
5QIN
7.8
-
TGFR2_HUMAN
A:
[8-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
P
I
E
L
D
T
L
V
G
K
G
R
F
A
E
V
Y
K
A
K
L
K
-QF
E
-
T
V
A
V
K
-----
I
F
P
Y
E
----
E
Y
A
S
W
K
T
E
K
D
I
F
S
D
I
N
L
K
---
H
E
N
I
L
Q
F
L
T
A
E
E
R
K
T
E
L
G
K
Q
Y
W
-
L
I
T
A
F
H
A
K
G
N
L
Q
E
Y
L
T
R
H
--
V
---
I
S
W
E
D
L
R
------
K
L
G
S
S
L
A
R
G
I
A
H
L
H
S
D
H
---
T
P
C
G
--
R
P
--
K
M
--
P
I
V
H
R
D
L
K
S
S
N
I
L
V
K
N
D
L
T
C
C
L
C
D
F
G
L
S
---
L
R
L
D
-
P
T
----
L
S
V
D
D
L
A
N
--
Q
V
G
T
A
---
R
Y
M
A
P
E
V
L
A
-
S
A
M
N
L
E
N
V
E
--
S
F
K
Q
T
D
V
Y
S
M
A
L
V
L
W
E
M
T
S
R
C
---
N
A
V
-
G
E
V
K
D
Y
E
P
P
F
G
S
K
V
-----------
R
E
H
P
C
V
A
S
M
A
D
N
V
L
A
D
A
G
R
P
E
I
P
S
-
F
W
L
N
H
Q
-
G
I
Q
M
V
C
E
T
L
T
E
C
W
D
H
D
P
E
A
R
L
T
A
Q
C
V
A
E
R
F
S
E
L
--------
129
Blastp_CBE
61.16
36%
-8
- C1 -
-
5E8Y
8.6
-
TGFR2_HUMAN
A:
[11-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
L
D
T
L
V
G
K
G
R
F
A
E
V
Y
K
A
K
L
K
Q
QF
E
-
T
V
A
V
K
-----
I
F
P
Y
E
----
E
Y
A
S
W
K
T
E
K
D
I
F
S
D
I
N
L
K
---
H
E
N
I
L
Q
F
L
T
A
E
E
R
K
T
E
L
G
K
Q
Y
W
-
L
I
T
A
F
H
A
K
G
N
L
Q
E
Y
L
T
R
H
--
V
---
I
S
W
E
D
L
R
------
K
L
G
S
S
L
A
R
G
I
A
H
L
H
S
D
----
H
T
-
P
--
C
G
--
R
P
KM
P
I
V
H
R
D
L
K
S
S
N
I
L
V
K
N
D
L
T
C
C
L
C
D
F
G
L
S
---
L
R
L
D
-
P
T
----
L
S
V
D
D
L
A
N
S
G
Q
V
G
T
A
---
R
Y
M
A
P
E
V
L
A
-
S
A
M
N
L
E
N
V
E
--
S
F
K
Q
T
D
V
Y
S
M
A
L
V
L
W
E
M
T
S
R
C
---
N
A
V
-
G
E
V
K
D
Y
E
P
P
F
G
S
K
V
-----------
R
E
H
P
C
V
A
S
M
A
D
N
V
L
A
D
A
G
R
P
E
I
P
S
-
F
W
L
N
H
Q
-
G
I
Q
M
V
C
E
T
L
T
E
C
W
D
H
D
P
E
A
R
L
T
A
Q
C
V
A
E
R
F
S
E
L
--------
124
Blastp_CBE
60.56
42%
-18
- C1 -
-
3Q4T
7.7
-
AVR2A_HUMAN
A:
[26-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
--
E
-
Y
V
A
V
K
-----
I
F
P
I
Q
----
D
K
Q
S
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
---
H
E
N
I
L
Q
F
I
G
A
E
K
R
G
T
S
V
D
V
D
L
W
-
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
A
N
--
V
---
V
S
W
N
E
L
C
------
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
---
P
G
-
L
--
K
D
GH
K
P
--
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
---
L
K
F
E
-
A
G
----
K
S
A
G
D
T
--
H
G
Q
V
G
T
R
---
R
Y
M
A
P
E
V
L
E
-
G
A
I
N
---
F
Q
RD
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
---
T
A
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
-----------
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
-
Y
W
Q
K
H
A
-
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
--------
119
Blastp_CBE
60.56
42%
-18
- C1 -
-
4ASX
5.4
-
AVR2A_HUMAN
B:
[26-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
--
E
-
Y
V
A
V
K
-----
I
F
P
I
Q
----
D
K
Q
S
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
---
H
E
N
I
L
Q
F
I
G
A
E
K
R
G
T
S
V
D
V
D
L
W
-
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
A
N
--
V
---
V
S
W
N
E
L
C
------
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
---
P
G
-
L
--
K
D
GH
K
P
--
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
---
L
K
F
E
-
A
G
----
K
S
A
G
D
T
--
H
G
Q
V
G
T
R
---
R
Y
M
A
P
E
V
L
E
-
G
A
I
N
---
F
Q
RD
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
---
T
A
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
-----------
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
-
Y
W
Q
K
H
A
-
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
--------
126
Blastp_CBE
60.46
36%
-5
- C1 -
-
5QIN
7.8
-
TGFR2_HUMAN
A:
[11-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
L
D
T
L
V
G
K
G
R
F
A
E
V
Y
K
A
K
L
K
-QF
E
-
T
V
A
V
K
-----
I
F
P
Y
E
----
E
Y
A
S
W
K
T
E
K
D
I
F
S
D
I
N
L
K
---
H
E
N
I
L
Q
F
L
T
A
E
E
R
K
T
E
L
G
K
Q
Y
W
-
L
I
T
A
F
H
A
K
G
N
L
Q
E
Y
L
T
R
H
--
V
---
I
S
W
E
D
L
R
------
K
L
G
S
S
L
A
R
G
I
A
H
L
H
S
D
----
H
T
-
P
--
C
G
--
R
P
KM
P
I
V
H
R
D
L
K
S
S
N
I
L
V
K
N
D
L
T
C
C
L
C
D
F
G
L
S
---
L
R
L
D
-
P
T
----
L
S
V
D
D
L
A
N
--
Q
V
G
T
A
---
R
Y
M
A
P
E
V
L
A
-
S
A
M
N
L
E
N
V
E
--
S
F
K
Q
T
D
V
Y
S
M
A
L
V
L
W
E
M
T
S
R
C
---
N
A
V
-
G
E
V
K
D
Y
E
P
P
F
G
S
K
V
-----------
R
E
H
P
C
V
A
S
M
A
D
N
V
L
A
D
A
G
R
P
E
I
P
S
-
F
W
L
N
H
Q
-
G
I
Q
M
V
C
E
T
L
T
E
C
W
D
H
D
P
E
A
R
L
T
A
Q
C
V
A
E
R
F
S
E
L
--------
122
Blastp_CBE
59.66
42%
-20
- C1 -
-
3SOC
7.1
-
AVR2A_HUMAN
A:
[26-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
--
E
-
Y
V
A
V
K
-----
I
F
P
I
Q
----
D
K
Q
S
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
---
H
E
N
I
L
Q
F
I
G
A
E
K
R
G
T
S
V
D
V
D
L
W
-
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
A
N
--
V
---
V
S
W
N
E
L
C
------
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
---
P
G
-
L
--
K
D
GH
K
P
--
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
---
L
K
F
E
-
A
G
----
K
S
A
G
D
T
--
H
G
Q
V
G
T
R
---
R
Y
M
A
P
E
V
L
E
-
G
A
I
N
---
F
Q
RD
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
---
T
A
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
-----------
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
-
Y
W
Q
K
H
A
-
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
--------
125
Blastp_CBE
59.07
39%
-37
- C1 -
-
2QLU
3.0
-
AVR2B_HUMAN
A:
[17-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
L
L
E
I
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
M
N
--
D
-
F
V
A
V
K
-----
I
F
P
L
Q
----
D
K
Q
S
W
Q
S
E
R
E
I
F
S
T
P
G
M
K
---
H
E
N
L
L
Q
F
I
A
A
E
K
R
G
S
N
L
E
V
E
L
W
-
L
I
T
A
F
H
D
K
G
S
L
T
D
Y
L
K
G
N
--
I
---
I
T
W
N
E
L
C
------
H
V
A
E
T
M
S
R
G
L
S
Y
L
H
E
D
V
PWC
R
G
-
E
--
G
H
--
K
P
--
S
I
A
H
R
D
F
K
S
K
N
V
L
L
K
S
D
L
T
A
V
L
A
D
F
G
L
A
---
V
R
F
E
-
P
G
----
K
P
P
G
D
T
--
H
G
Q
V
G
T
R
---
R
Y
M
A
P
E
V
L
E
-
G
A
I
N
---
F
Q
RD
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
V
S
R
C
---
K
A
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
-----------
G
Q
H
P
S
L
E
E
L
Q
E
V
V
V
H
K
K
M
R
P
T
I
K
D
-
H
W
L
K
H
P
-
G
L
A
Q
L
C
V
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
------------------
131
Blastp_CBE
54.83
37%
-34
- C1 -
-
3G2F
6.0
-
BMPR2_HUMAN
B:
[14-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
K
L
L
E
L
I
G
R
G
R
Y
G
A
V
Y
K
G
S
L
D
E
--
R
-
P
V
A
V
K
-----
V
F
S
F
A
----
N
R
Q
N
F
I
N
E
K
N
I
Y
R
V
P
L
M
E
---
H
D
N
I
A
R
F
I
V
G
D
E
R
V
T
A
D
G
R
M
E
Y
L
L
V
M
E
Y
Y
P
N
G
S
L
C
K
Y
L
S
L
H
--
T
---
S
D
W
V
S
S
C
------
R
L
A
H
S
V
T
R
G
L
A
Y
L
H
T
E
L
P--
R
G
-
D
--
H
Y
--
K
P
--
A
I
S
H
R
D
L
N
S
R
N
V
L
V
K
N
D
G
T
C
V
I
S
D
F
G
L
S
---
M
R
L
T
-
G
N
RL-------------
V
G
T
I
---
R
Y
M
A
P
E
V
L
E
-
G
A
V
N
L
R
D
E
S
--
A
L
K
Q
V
D
M
Y
A
L
G
L
I
Y
W
E
I
F
M
R
C
TDL
F
P
G
-
E
S
V
P
E
Y
Q
M
A
F
Q
T
E
V
-----------
G
N
H
P
T
F
E
D
M
Q
V
L
V
S
R
E
K
Q
R
P
K
F
P
E
-
A
W
K
E
N
S
L
A
V
R
S
L
K
E
T
I
E
D
C
W
D
Q
D
A
E
A
R
L
T
A
------------------
132
Blastp_CBE
53.74
37%
-28
- C1 -
-
3G2F
6.3
-
BMPR2_HUMAN
A:
[14-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
K
L
L
E
L
I
G
R
G
R
Y
G
A
V
Y
K
G
S
L
D
E
--
R
-
P
V
A
V
K
-----
V
F
S
F
A
----
N
R
Q
N
F
I
N
E
K
N
I
Y
R
V
P
L
M
E
---
H
D
N
I
A
R
F
I
V
G
D
E
R
V
T
A
D
G
R
M
E
Y
L
L
V
M
E
Y
Y
P
N
G
S
L
C
K
Y
L
S
L
H
--
T
---
S
D
W
V
S
S
C
------
R
L
A
H
S
V
T
R
G
L
A
Y
L
H
T
E
L
P--
R
G
-
D
--
H
Y
--
K
P
--
A
I
S
H
R
D
L
N
S
R
N
V
L
V
K
N
D
G
T
C
V
I
S
D
F
G
L
S
---
M
R
L
T
-
G
N
RLVR
P
---------
E
V
G
T
I
---
R
Y
M
A
P
E
V
L
E
-
G
A
V
N
L
R
D
E
S
--
A
L
K
Q
V
D
M
Y
A
L
G
L
I
Y
W
E
I
F
M
R
C
TDL
F
P
G
-
E
S
V
P
E
Y
Q
M
A
F
Q
T
E
V
-----------
G
N
H
P
T
F
E
D
M
Q
V
L
V
S
R
E
K
Q
R
P
K
F
P
E
-
A
W
K
E
N
S
L
A
V
R
S
L
K
E
T
I
E
D
C
W
D
Q
D
A
E
A
R
L
T
A
------------------
142
Blastp_CBE
45.96
31%
-21
- C1 -
-
5JSM
3.5
-
D:
[13-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
--
V
A
V
K
-----
M
L
N
V
-PTP-
Q
Q
L
Q
A
F
K
-
N
E
V
G
V
L
R
K
T
R
---
H
V
N
I
L
L
F
M
G
Y
S
T
K
-----
P
Q
L
A
-
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
ET
K
---
F
E
M
K
K
L
I
------
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
------------------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
---
T
E
K
S
------------------
S
G
S
I
---
L
W
M
A
P
E
V
I
R
M---
N
P
Y
S
F
Q
------
S
D
V
Y
A
F
G
I
V
L
Y
E
L
-------
M
T
G
-------
Q
L
P
Y
S
N
I
--------------
D
----
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
----
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
---------------
144
Blastp_CBE
43.84
31%
-8
- C1 -
-
5JSM
3.5
-
BRAF_HUMAN
B:
[13-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
--
V
A
V
K
-----
M
L
N
V
T
APTP
Q
Q
L
Q
A
F
K
-
N
E
V
G
V
L
R
K
T
R
---
H
V
N
I
L
L
F
M
G
Y
S
T
K
-----
P
Q
L
A
-
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
ET
K
---
F
E
M
K
K
L
I
------
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
------------------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
---
T
E
K
S
R-------------------
S
I
---
L
W
M
A
P
E
V
I
R
M---
N
P
Y
S
F
Q
------
S
D
V
Y
A
F
G
I
V
L
Y
E
L
-------
M
T
G
-------
Q
L
P
Y
S
N
I
N
-----------
N
R
D
----
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
----
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
---------------
147
Blastp_CBE
43.01
31%
-7
- C1 -
-
5JRQ
3.5
-
BRAF_HUMAN
A:
[13-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
--
V
A
V
K
-----
M
L
N
V
T
APTP
Q
Q
L
Q
A
F
K
-
N
E
V
G
V
L
R
K
T
R
---
H
V
N
I
L
L
F
M
G
Y
S
T
K
-----
P
Q
L
A
-
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
ET
K
---
F
E
M
K
K
L
I
------
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
------------------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
---
T
E
K
S
R-------------------
S
I
---
L
W
M
A
P
E
V
I
R
M---
N
P
Y
S
F
Q
------
S
D
V
Y
A
F
G
I
V
L
Y
E
L
-------
M
T
G
-------
Q
L
P
Y
S
N
I
N
-----------
N
R
D
----
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
----
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
---------------
145
Blastp_CBE
42.49
31%
-6
- C1 -
-
5JSM
3.4
-
BRAF_HUMAN
A:
[13-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
--
V
A
V
K
-----
M
L
N
V
T
APTP
Q
Q
L
Q
A
F
K
-
N
E
V
G
V
L
R
K
T
R
---
H
V
N
I
L
L
F
M
G
Y
S
T
K
-----
P
Q
L
A
-
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
ET
K
---
F
E
M
K
K
L
I
------
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
------------------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
---
T
E
K
-------------------
S
G
S
I
---
L
W
M
A
P
E
V
I
R
M
Q
D
S
N
P
Y
S
F
Q
------
S
D
V
Y
A
F
G
I
V
L
Y
E
L
-------
M
T
G
-------
Q
L
P
Y
S
N
I
N
-----------
N
R
D
----
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
----
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
---------------
165
Blastp_CBE
41.43
31%
-4
- C1 -
-
3ACJ
5.0
-
LCK_HUMAN
A:
[21-262]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
T
K
V
A
V
K
--------
S
L
----
K
Q
G
S
M
S
P
D
A
F
L
A
E
A
N
L
M
K
QLQ
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
-----
E
P
I
Y
-
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
--
S
GIK
L
T
I
N
K
L
L
------
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
---
Y
---------------
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
---
R
L
I
---
E
----
D
N
E
T
-----
A
R
E
G
A
K
FPI
K
W
T
A
P
-----
E
A
I
N
Y
G
T
F
T
----
I
K
S
D
V
W
S
F
G
I
L
L
T
E
-------------
I
V
T
H
G
R
I
P
Y
P
G
M
-------------
T
N
P
E
V
I
Q
N
L
E
-
R
G
Y
R
M
V
R
P
---------
D
N
-
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
-------------------
160
Blastp_CBE
41.40
31%
-2
- C1 -
-
2OFU
7.2
-
LCK_HUMAN
A:
[17-258]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
T
K
V
A
V
K
--------
S
L
----
K
Q
G
S
M
S
P
D
A
F
L
A
E
A
N
L
M
K
QLQ
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
-----
E
P
I
Y
-
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
--
S
GIK
L
T
I
N
K
L
L
------
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
---
Y
---------------
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
---
R
L
I
---
E
----
D
N
E
T
-----
A
R
E
G
A
K
FPI
K
W
T
A
P
-----
E
A
I
N
Y
G
T
F
T
----
I
K
S
D
V
W
S
F
G
I
L
L
T
E
-------------
I
V
T
H
G
R
I
P
Y
P
G
M
-------------
T
N
P
E
V
I
Q
N
L
E
-
R
G
Y
R
M
V
R
P
---------
D
N
-
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
-------------------
174
Blastp_CBE
41.39
31%
-2
- C1 -
-
2ZM1
6.0
-
LCK_HUMAN
A:
[21-262]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
T
K
V
A
V
K
--------
S
L
----
K
Q
G
S
M
S
P
D
A
F
L
A
E
A
N
L
M
K
QLQ
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
-----
E
P
I
Y
-
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
--
S
GIK
L
T
I
N
K
L
L
------
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
---
Y
---------------
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
---
R
L
I
---
E
----
D
N
E
T
-----
A
R
E
G
A
K
FPI
K
W
T
A
P
-----
E
A
I
N
Y
G
T
F
T
----
I
K
S
D
V
W
S
F
G
I
L
L
T
E
-------------
I
V
T
H
G
R
I
P
Y
P
G
M
-------------
T
N
P
E
V
I
Q
N
L
E
-
R
G
Y
R
M
V
R
P
---------
D
N
-
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
-------------------
172
Blastp_CBE
41.18
31%
-5
- C1 -
-
2ZYB
5.8
-
LCK_HUMAN
A:
[21-262]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
T
K
V
A
V
K
--------
S
L
----
K
Q
G
S
M
S
P
D
A
F
L
A
E
A
N
L
M
K
QLQ
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
-----
E
P
I
Y
-
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
--
S
GIK
L
T
I
N
K
L
L
------
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
---
Y
---------------
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
---
R
L
I
---
E
----
D
N
E
T
-----
A
R
E
G
A
K
FPI
K
W
T
A
P
-----
E
A
I
N
Y
G
T
F
T
----
I
K
S
D
V
W
S
F
G
I
L
L
T
E
-------------
I
V
T
H
G
R
I
P
Y
P
G
M
-------------
T
N
P
E
V
I
Q
N
L
E
-
R
G
Y
R
M
V
R
P
---------
D
N
-
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
-------------------
156
Blastp_CBE
41.17
31%
-8
- C1 -
-
3KXZ
8.2
-
LCK_HUMAN
A:
[23-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
T
K
V
A
V
K
--------
S
L
----
K
Q
G
S
M
S
P
D
A
F
L
A
E
A
N
L
M
K
QLQ
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
-----
E
P
I
Y
-
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
--
S
GIK
L
T
I
N
K
L
L
------
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
---
Y
---------------
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
---
R
L
I
---
E
----
D
N
E
T
-----
A
R
E
G
A
K
FPI
K
W
T
A
P
-----
E
A
I
N
Y
G
T
F
T
----
I
K
S
D
V
W
S
F
G
I
L
L
T
E
-------------
I
V
T
H
G
R
I
P
Y
P
G
M
-------------
T
N
P
E
V
I
Q
N
L
E
-
R
G
Y
R
M
V
R
P
---------
D
N
-
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
-------------------
167
Blastp_CBE
40.99
31%
-4
* C1 *
-
3AC5
7.6
-
LCK_HUMAN
A:
[21-262]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
T
K
V
A
V
K
--------
S
L
----
K
Q
G
S
M
S
P
D
A
F
L
A
E
A
N
L
M
K
QLQ
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
-----
E
P
I
Y
-
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
--
S
GIK
L
T
I
N
K
L
L
------
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
---
Y
---------------
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
---
R
L
I
---
E
----
D
N
E
T
-----
A
R
E
G
A
K
FPI
K
W
T
A
P
-----
E
A
I
N
Y
G
T
F
T
----
I
K
S
D
V
W
S
F
G
I
L
L
T
E
-------------
I
V
T
H
G
R
I
P
Y
P
G
M
-------------
T
N
P
E
V
I
Q
N
L
E
-
R
G
Y
R
M
V
R
P
---------
D
N
-
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
-------------------
159
Blastp_CBE
40.88
31%
-2
- C1 -
-
3KMM
7.0
-
LCK_HUMAN
A:
[24-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
T
K
V
A
V
K
--------
S
L
----
K
Q
G
S
M
S
P
D
A
F
L
A
E
A
N
L
M
K
QLQ
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
-----
E
P
I
Y
-
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
--
S
GIK
L
T
I
N
K
L
L
------
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
---
Y
---------------
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
---
R
L
I
---
E
----
D
N
E
T
-----
A
R
E
G
A
K
FPI
K
W
T
A
P
-----
E
A
I
N
Y
G
T
F
T
----
I
K
S
D
V
W
S
F
G
I
L
L
T
E
-------------
I
V
T
H
G
R
I
P
Y
P
G
M
-------------
T
N
P
E
V
I
Q
N
L
E
-
R
G
Y
R
M
V
R
P
---------
D
N
-
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
-------------------
173
Blastp_CBE
40.61
31%
-6
- C1 -
-
2ZM4
5.8
-
LCK_HUMAN
A:
[21-262]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
T
K
V
A
V
K
--------
S
L
----
K
Q
G
S
M
S
P
D
A
F
L
A
E
A
N
L
M
K
QLQ
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
-----
E
P
I
Y
-
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
--
S
GIK
L
T
I
N
K
L
L
------
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
---
Y
---------------
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
---
R
L
I
---
E
----
D
N
E
T
-----
A
R
E
G
A
K
FPI
K
W
T
A
P
-----
E
A
I
N
Y
G
T
F
T
----
I
K
S
D
V
W
S
F
G
I
L
L
T
E
-------------
I
V
T
H
G
R
I
P
Y
P
G
M
-------------
T
N
P
E
V
I
Q
N
L
E
-
R
G
Y
R
M
V
R
P
---------
D
N
-
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
-------------------
175
Blastp_CBE
40.57
31%
-8
- C1 -
-
6PDJ
6.3
-
?
A:
[24-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
T
K
V
A
V
K
--------
S
L
----
K
Q
G
S
M
S
P
D
A
F
L
A
E
A
N
L
M
K
QLQ
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
-----
E
P
I
Y
-
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
--
S
GIK
L
T
I
N
K
L
L
------
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
---
Y
---------------
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
---
R
L
I
---
E
----
D
N
E
T
-----
A
R
E
G
A
K
FPI
K
W
T
A
P
-----
E
A
I
N
Y
G
T
F
T
----
I
K
S
D
V
W
S
F
G
I
L
L
T
E
-------------
I
V
T
H
G
R
I
P
Y
P
G
M
-------------
T
N
P
E
V
I
Q
N
L
E
-
R
G
Y
R
M
V
R
P
---------
D
N
-
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
-------------------
164
Blastp_CBE
40.41
31%
-1
- C1 -
-
3ACK
5.1
-
LCK_HUMAN
A:
[21-262]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
T
K
V
A
V
K
--------
S
L
----
K
Q
G
S
M
S
P
D
A
F
L
A
E
A
N
L
M
K
QLQ
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
-----
E
P
I
Y
-
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
--
S
GIK
L
T
I
N
K
L
L
------
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
---
Y
---------------
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
---
R
L
I
---
E
----
D
N
E
T
-----
A
R
E
G
A
K
FPI
K
W
T
A
P
-----
E
A
I
N
Y
G
T
F
T
----
I
K
S
D
V
W
S
F
G
I
L
L
T
E
-------------
I
V
T
H
G
R
I
P
Y
P
G
M
-------------
T
N
P
E
V
I
Q
N
L
E
-
R
G
Y
R
M
V
R
P
---------
D
N
-
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
-------------------
161
Blastp_CBE
40.37
31%
3
- C1 -
-
3AD6
5.0
-
LCK_HUMAN
A:
[21-262]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
T
K
V
A
V
K
--------
S
L
----
K
Q
G
S
M
S
P
D
A
F
L
A
E
A
N
L
M
K
QLQ
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
-----
E
P
I
Y
-
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
--
S
GIK
L
T
I
N
K
L
L
------
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
---
Y
---------------
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
---
R
L
I
---
E
----
D
N
E
T
-----
A
R
E
G
A
K
FPI
K
W
T
A
P
-----
E
A
I
N
Y
G
T
F
T
----
I
K
S
D
V
W
S
F
G
I
L
L
T
E
-------------
I
V
T
H
G
R
I
P
Y
P
G
M
-------------
T
N
P
E
V
I
Q
N
L
E
-
R
G
Y
R
M
V
R
P
---------
D
N
-
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
-------------------
163
Blastp_CBE
40.29
31%
-4
- C1 -
-
3AD4
4.5
-
LCK_HUMAN
A:
[21-262]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
T
K
V
A
V
K
--------
S
L
----
K
Q
G
S
M
S
P
D
A
F
L
A
E
A
N
L
M
K
QLQ
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
-----
E
P
I
Y
-
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
--
S
GIK
L
T
I
N
K
L
L
------
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
---
Y
---------------
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
---
R
L
I
---
E
----
D
N
E
T
-----
A
R
E
G
A
K
FPI
K
W
T
A
P
-----
E
A
I
N
Y
G
T
F
T
----
I
K
S
D
V
W
S
F
G
I
L
L
T
E
-------------
I
V
T
H
G
R
I
P
Y
P
G
M
-------------
T
N
P
E
V
I
Q
N
L
E
-
R
G
Y
R
M
V
R
P
---------
D
N
-
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
-------------------
170
Blastp_CBE
40.26
31%
0
- C1 -
-
3AC2
5.2
-
LCK_HUMAN
A:
[21-262]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
T
K
V
A
V
K
--------
S
L
----
K
Q
G
S
M
S
P
D
A
F
L
A
E
A
N
L
M
K
QLQ
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
-----
E
P
I
Y
-
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
--
S
GIK
L
T
I
N
K
L
L
------
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
---
Y
---------------
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
---
R
L
I
---
E
----
D
N
E
T
-----
A
R
E
G
A
K
FPI
K
W
T
A
P
-----
E
A
I
N
Y
G
T
F
T
----
I
K
S
D
V
W
S
F
G
I
L
L
T
E
-------------
I
V
T
H
G
R
I
P
Y
P
G
M
-------------
T
N
P
E
V
I
Q
N
L
E
-
R
G
Y
R
M
V
R
P
---------
D
N
-
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
-------------------
192
Blastp_CBE
40.14
31%
1
- C1 -
-
3BYM
7.5
-
LCK_HUMAN
A:
[16-257]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
T
K
V
A
V
K
--------
S
L
----
K
Q
G
S
M
S
P
D
A
F
L
A
E
A
N
L
M
K
QLQ
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
-----
E
P
I
Y
-
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
--
S
GIK
L
T
I
N
K
L
L
------
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
---
Y
---------------
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
---
R
L
I
---
E
----
D
N
E
T
-----
A
R
E
G
A
K
FPI
K
W
T
A
P
-----
E
A
I
N
Y
G
T
F
T
----
I
K
S
D
V
W
S
F
G
I
L
L
T
E
-------------
I
V
T
H
G
R
I
P
Y
P
G
M
-------------
T
N
P
E
V
I
Q
N
L
E
-
R
G
Y
R
M
V
R
P
---------
D
N
-
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
-------------------
162
Blastp_CBE
40.12
31%
-0
- C1 -
-
3AD5
6.2
-
LCK_HUMAN
A:
[21-262]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
T
K
V
A
V
K
--------
S
L
----
K
Q
G
S
M
S
P
D
A
F
L
A
E
A
N
L
M
K
QLQ
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
-----
E
P
I
Y
-
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
--
S
GIK
L
T
I
N
K
L
L
------
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
---
Y
---------------
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
---
R
L
I
---
E
----
D
N
E
T
-----
A
R
E
G
A
K
FPI
K
W
T
A
P
-----
E
A
I
N
Y
G
T
F
T
----
I
K
S
D
V
W
S
F
G
I
L
L
T
E
-------------
I
V
T
H
G
R
I
P
Y
P
G
M
-------------
T
N
P
E
V
I
Q
N
L
E
-
R
G
Y
R
M
V
R
P
---------
D
N
-
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
-------------------
166
Blastp_CBE
40.11
31%
-5
- C1 -
-
3AC8
5.2
-
LCK_HUMAN
A:
[21-262]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
T
K
V
A
V
K
--------
S
L
----
K
Q
G
S
M
S
P
D
A
F
L
A
E
A
N
L
M
K
QLQ
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
-----
E
P
I
Y
-
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
--
S
GIK
L
T
I
N
K
L
L
------
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
---
Y
---------------
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
---
R
L
I
---
E
----
D
N
E
T
-----
A
R
E
G
A
K
FPI
K
W
T
A
P
-----
E
A
I
N
Y
G
T
F
T
----
I
K
S
D
V
W
S
F
G
I
L
L
T
E
-------------
I
V
T
H
G
R
I
P
Y
P
G
M
-------------
T
N
P
E
V
I
Q
N
L
E
-
R
G
Y
R
M
V
R
P
---------
D
N
-
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
-------------------
168
Blastp_CBE
39.93
31%
-1
- C1 -
-
3AC4
4.3
-
LCK_HUMAN
A:
[21-262]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
T
K
V
A
V
K
--------
S
L
----
K
Q
G
S
M
S
P
D
A
F
L
A
E
A
N
L
M
K
QLQ
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
-----
E
P
I
Y
-
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
--
S
GIK
L
T
I
N
K
L
L
------
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
---
Y
---------------
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
---
R
L
I
---
E
----
D
N
E
T
-----
A
R
E
G
A
K
FPI
K
W
T
A
P
-----
E
A
I
N
Y
G
T
F
T
----
I
K
S
D
V
W
S
F
G
I
L
L
T
E
-------------
I
V
T
H
G
R
I
P
Y
P
G
M
-------------
T
N
P
E
V
I
Q
N
L
E
-
R
G
Y
R
M
V
R
P
---------
D
N
-
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
-------------------
171
Blastp_CBE
39.85
31%
0
- C1 -
-
3AC1
4.9
-
LCK_HUMAN
A:
[21-262]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
T
K
V
A
V
K
--------
S
L
----
K
Q
G
S
M
S
P
D
A
F
L
A
E
A
N
L
M
K
QLQ
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
-----
E
P
I
Y
-
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
--
S
GIK
L
T
I
N
K
L
L
------
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
---
Y
---------------
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
---
R
L
I
---
E
----
D
N
E
T
-----
A
R
E
G
A
K
FPI
K
W
T
A
P
-----
E
A
I
N
Y
G
T
F
T
----
I
K
S
D
V
W
S
F
G
I
L
L
T
E
-------------
I
V
T
H
G
R
I
P
Y
P
G
M
-------------
T
N
P
E
V
I
Q
N
L
E
-
R
G
Y
R
M
V
R
P
---------
D
N
-
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
-------------------
169
Blastp_CBE
39.66
31%
4
- C1 -
-
3AC3
5.2
-
LCK_HUMAN
A:
[21-262]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
T
K
V
A
V
K
--------
S
L
----
K
Q
G
S
M
S
P
D
A
F
L
A
E
A
N
L
M
K
QLQ
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
-----
E
P
I
Y
-
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
--
S
GIK
L
T
I
N
K
L
L
------
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
---
Y
---------------
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
---
R
L
I
---
E
----
D
N
E
T
-----
A
R
E
G
A
K
FPI
K
W
T
A
P
-----
E
A
I
N
Y
G
T
F
T
----
I
K
S
D
V
W
S
F
G
I
L
L
T
E
-------------
I
V
T
H
G
R
I
P
Y
P
G
M
-------------
T
N
P
E
V
I
Q
N
L
E
-
R
G
Y
R
M
V
R
P
---------
D
N
-
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
-------------------
194
Blastp_CBE
39.63
31%
-1
- C1 -
-
3BYO
8.6
-
?
A:
[15-256]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
T
K
V
A
V
K
--------
S
L
----
K
Q
G
S
M
S
P
D
A
F
L
A
E
A
N
L
M
K
QLQ
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
-----
E
P
I
Y
-
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
--
S
GIK
L
T
I
N
K
L
L
------
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
---
Y
---------------
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
---
R
L
I
---
E
----
D
N
E
T
-----
A
R
E
G
A
K
FPI
K
W
T
A
P
-----
E
A
I
N
Y
G
T
F
T
----
I
K
S
D
V
W
S
F
G
I
L
L
T
E
-------------
I
V
T
H
G
R
I
P
Y
P
G
M
-------------
T
N
P
E
V
I
Q
N
L
E
-
R
G
Y
R
M
V
R
P
---------
D
N
-
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
-------------------
296
Blastp_CBE
36.78
33%
-31
- C1 -
-
6MOM
7.6
-
?
C:
[34-236]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
-
T
V
A
V
K
KLA---
D
I
T
T
----
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
---
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
----
D
L
C
-
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-------
L
D
G
T
P
P
L
SWHMRC
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
H
---
H
---------------
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
----
A
S
E
K
F
A
Q
V
M
R
I
V
G
T
T
---
A
Y
M
A
P
E
A
L
------
R
G
E
I
T
--
P
--
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
-------
I
T
G
L
P
A
V
D
E
H
R
E
P
-----------------------------------------------------------------------------------------
298
Blastp_CBE
36.38
33%
-29
- C1 -
-
6MOM
8.5
-
?
A:
[34-236]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
-
T
V
A
V
K
KLA-----
T
T
----
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
---
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
----
D
L
C
-
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-------
L
D
G
T
P
P
L
SWHMRC
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
H
---
H
---------------
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
----
A
S
E
K
F
A
Q
V
M
R
I
V
G
T
T
---
A
Y
M
A
P
E
A
L
------
R
G
E
I
T
--
P
--
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
-------
I
T
G
L
P
A
V
D
E
H
R
E
P
-----------------------------------------------------------------------------------------
369
Blastp_CBE
35.88
33%
-39
- C1 -
-
5K7G
6.7
-
IRAK4_HUMAN
A:
[32-234]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
-
T
V
A
V
K
KLA-------------
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
---
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
----
D
L
C
-
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-------
L
D
G
T
P
P
L
SWHMRC
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
H
---
H
---------------
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
RAS------
T
----
V
M
R
I
-------
V
G
T
T
---
A
Y
M
A
P
E
A
L
------
R
G
E
I
T
--
P
--
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
-------
I
T
G
L
P
A
V
D
E
H
R
E
P
-----------------------------------------------------------------------------------------
357
Blastp_CBE
34.59
33%
-27
- C1 -
-
6O8U
3.2
-
IRAK4_HUMAN
A:
[33-235]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
-
T
V
A
V
K
KL------
T
T
----
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
---
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
----
D
L
C
-
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-------
L
D
G
T
P
P
L
SWHMRC
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
H
---
H
---------------
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
RAS-----
Q
T
----
V
M
R
I
-------
V
G
T
T
---
A
Y
M
A
P
E
A
L
------
R
G
E
I
T
--
P
--
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
-------
I
T
G
L
P
A
V
D
E
H
R
E
P
-----------------------------------------------------------------------------------------
349
Blastp_CBE
34.31
33%
-35
- C1 -
-
2OIC
8.1
-
IRAK4_HUMAN
A:
[32-234]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
-
T
V
A
V
K
K---------------
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
---
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
----
D
L
C
-
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-------
L
D
G
T
P
P
L
SWHMRC
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
H
---
H
---------------
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
----
A
S
---
A
Q
V
M
R
I
V
G
T
T
---
A
Y
M
A
P
E
A
L
------
R
G
E
I
T
--
P
--
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
-------
I
T
G
L
P
A
V
D
E
H
R
E
P
-----------------------------------------------------------------------------------------
365
Blastp_CBE
34.24
33%
-34
- C1 -
-
5K7I
7.0
-
IRAK4_HUMAN
A:
[32-234]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
-
T
V
A
V
K
KL--------------
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
---
H
E
N
L
V
E
L
L
G
F
S
--------
D
L
C
-
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-------
L
D
G
T
P
P
L
SWHMRC
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
H
---
H
---------------
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
RAS------
T
----
V
M
R
I
-------
V
G
T
T
---
A
Y
M
A
P
E
A
L
------
R
G
E
I
T
--
P
--
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
-------
I
T
G
L
P
A
V
D
E
H
R
E
P
-----------------------------------------------------------------------------------------
373
Blastp_CBE
34.21
33%
-22
- C1 -
-
5K75
5.9
-
IRAK4_HUMAN
C:
[32-234]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
-
T
V
A
V
K
KL-----
I
T
T
----
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
---
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
----
D
L
C
-
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-------
L
D
G
T
P
P
L
SWHMRC
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
H
---
H
---------------
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
RAS-----
Q
T
----
V
M
R
I
-------
V
G
T
T
---
A
Y
M
A
P
E
A
L
------
R
G
E
I
T
--
P
--
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
-------
I
T
G
L
P
A
V
D
E
H
R
E
P
-----------------------------------------------------------------------------------------
374
Blastp_CBE
33.76
33%
-22
- C1 -
-
5K75
5.8
-
IRAK4_HUMAN
B:
[32-234]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
-
T
V
A
V
K
KL------
T
T
----
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
---
H
E
N
L
V
E
L
L
G
F
S
S
--
D
----
D
L
C
-
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-------
L
D
G
T
P
P
L
SWHMRC
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
H
---
H
---------------
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
RAS-----
Q
T
----
V
M
R
I
-------
V
G
T
T
---
A
Y
M
A
P
E
A
L
------
R
G
E
I
T
--
P
--
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
-------
I
T
G
L
P
A
V
D
E
H
R
E
P
-----------------------------------------------------------------------------------------
314
Blastp_CBE
33.25
33%
-24
- C1 -
-
5KX8
5.7
-
IRAK4_HUMAN
C:
[32-234]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
-
T
V
A
V
K
KLAA----
T
T
----
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
---
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
----
D
L
C
-
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-------
L
D
G
T
P
P
L
SWHMRC
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
H
---
H
---------------
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
----
A
S
E
K
-
A
Q
V
M
R
I
V
G
T
T
---
A
Y
M
A
P
E
A
L
------
R
G
E
I
T
--
P
--
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
-------
I
T
G
L
P
A
V
D
E
H
R
E
P
-----------------------------------------------------------------------------------------
404
Blastp_CBE
33.22
33%
-29
- C1 -
-
5UIS
6.0
-
IRAK4_HUMAN
A:
[54-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
G
E
G
--
G
V
V
Y
K
G
Y
V
N
N
--
T
-
T
V
A
V
K
K---------------
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
---
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
----
D
L
C
-
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-------
L
D
G
T
P
P
L
SWHMRC
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
H
---
H
---------------
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
--------
R
A
----------
V
M
S
R
I
V
G
T
T
---
A
Y
M
A
P
E
A
L
------
R
G
E
I
T
--
P
--
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
-------
I
T
G
L
P
A
V
D
E
H
R
E
P
-----------------------------------------------------------------------------------------
375
Blastp_CBE
33.20
33%
-30
- C1 -
-
5K75
6.1
-
IRAK4_HUMAN
A:
[32-234]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
G
E
G
---
V
V
Y
K
G
Y
V
N
N
--
T
-
T
V
A
V
K
KLA-------------
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
---
H
E
N
L
V
E
L
L
G
F
S
S
D
G
------
L
C
-
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-------
L
D
G
T
P
P
L
SWHMRC
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
H
---
H
---------------
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
RA-------
T
----
V
M
R
I
-------
V
G
T
T
---
A
Y
M
A
P
E
A
L
------
R
G
E
I
T
--
P
--
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
-------
I
T
G
L
P
A
V
D
E
H
R
E
P
-----------------------------------------------------------------------------------------
297
Blastp_CBE
32.96
33%
-12
- C1 -
-
6MOM
8.4
-
?
B:
[34-236]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
-
T
V
A
V
K
KLAA---
I
T
T
----
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
---
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
----
D
L
C
-
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-------
L
D
G
T
P
P
L
SWHMRC
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
H
---
H
---------------
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
----
A
S
E
K
-
A
Q
V
M
R
I
V
G
T
T
---
A
Y
M
A
P
E
A
L
------
R
G
E
I
T
--
P
--
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
-------
I
T
G
L
P
A
V
D
E
H
R
E
P
-----------------------------------------------------------------------------------------
289
Blastp_CBE
32.92
33%
-21
- C1 -
-
2NRY
5.0
-
IRAK4_HUMAN
B:
[38-240]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
-
T
V
A
V
K
KLAA---
I
T
T
----
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
---
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
----
D
L
C
-
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-------
L
D
G
T
P
P
L
SWHMRC
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
H
---
H
---------------
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---
R
A
S
---------
Q
T
V
---
M
S
R
I
V
G
T
T
---
A
Y
M
A
P
E
A
L
------
R
G
E
I
T
--
P
--
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
-------
I
T
G
L
P
A
V
D
E
H
R
E
P
-----------------------------------------------------------------------------------------
348
Blastp_CBE
32.80
33%
-23
- C1 -
-
2OIC
7.9
-
IRAK4_HUMAN
B:
[32-234]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
G
E
G
--
G
V
V
Y
K
G
Y
V
N
N
--
T
-
T
V
A
V
K
KL--------------
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
---
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
----
D
L
C
-
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-------
L
D
G
T
P
P
L
SWHMRC
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
H
---
H
---------------
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
----
A
S
---
A
Q
V
M
R
I
V
G
T
T
---
A
Y
M
A
P
E
A
L
------
R
G
E
I
T
--
P
--
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
-------
I
T
G
L
P
A
V
D
E
H
R
E
P
-----------------------------------------------------------------------------------------
427
Blastp_CBE
32.75
33%
-13
- C1 -
-
6F3I
6.5
-
IRAK4_HUMAN
B:
[53-255]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
-
T
V
A
V
K
KL-------
T
----
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
---
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
----
D
L
C
-
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-------
L
D
G
T
P
P
L
SWHMRC
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
H
---
H
---------------
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
RAS------
T
----
V
M
R
I
-------
V
G
T
T
---
A
Y
M
A
P
E
A
L
------
R
G
E
I
T
--
P
--
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
-------
I
T
G
L
P
A
V
D
E
H
R
E
P
-----------------------------------------------------------------------------------------
303
Blastp_CBE
32.51
33%
-21
- C1 -
-
4Y73
7.8
-
IRAK4_HUMAN
B:
[33-235]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
-
T
V
A
V
K
KLAAM
V
D
I
T
T
----
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
---
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
----
D
L
C
-
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-------
L
D
G
T
P
P
L
SWHMRC
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
H
---
H
---------------
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
----
A
----
A
Q
V
M
R
I
V
G
T
T
---
A
Y
M
A
P
E
A
L
------
R
G
E
I
T
--
P
--
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
-------
I
T
G
L
P
A
V
D
E
H
R
E
P
-----------------------------------------------------------------------------------------
329
Blastp_CBE
32.41
33%
-30
- C1 -
-
4ZTL
7.0
-
IRAK4_HUMAN
A:
[32-234]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
-
T
V
A
V
K
KLA-----
T
T
----
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
---
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
----
D
L
C
-
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-------
L
D
G
T
P
P
L
SWHMRC
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
H
---
H
---------------
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
----
A
----
A
Q
V
M
R
I
V
G
T
T
---
A
Y
M
A
P
E
A
L
------
R
G
E
I
T
--
P
--
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
-------
I
T
G
L
P
A
V
D
E
H
R
E
P
-----------------------------------------------------------------------------------------
315
Blastp_CBE
32.40
33%
-39
- C1 -
-
5KX8
5.5
-
IRAK4_HUMAN
B:
[32-234]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
-
T
V
A
V
K
KLA----------------
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
---
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
----
D
L
C
-
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-------
L
D
G
T
P
P
L
SWHMRC
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
H
---
H
---------------
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
----
A
----
A
Q
V
M
R
I
V
G
T
T
---
A
Y
M
A
P
E
A
L
------
R
G
E
I
T
--
P
--
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
-------
I
T
G
L
P
A
V
D
E
H
R
E
P
-----------------------------------------------------------------------------------------
326
Blastp_CBE
32.30
33%
-31
- C1 -
-
4ZTL
7.3
-
IRAK4_HUMAN
D:
[32-234]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
G
E
G
-
F
G
V
V
Y
K
G
Y
V
N
N
--
T
-
T
V
A
V
K
KLAA----
T
T
----
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
---
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
----
D
L
C
-
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-------
L
D
G
T
P
P
L
SWHMRC
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
H
---
H
---------------
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
----
A
S
E
K
-
A
Q
V
M
R
I
V
G
T
T
---
A
Y
M
A
P
E
A
L
------
R
G
E
I
T
--
P
--
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
-------
I
T
G
L
P
A
V
D
E
H
R
E
P
-----------------------------------------------------------------------------------------
322
Blastp_CBE
32.30
33%
-20
- C1 -
-
4ZTM
6.7
-
IRAK4_HUMAN
D:
[32-234]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
G
E
G
-
F
G
V
V
Y
K
G
Y
V
N
N
--
T
-
T
V
A
V
K
KLA-----
T
T
----
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
---
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
----
D
L
C
-
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-------
L
D
G
T
P
P
L
SWHMRC
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
H
---
H
---------------
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
----
A
S
E
K
F
A
Q
--
R
I
V
G
T
T
---
A
Y
M
A
P
E
A
L
------
R
G
E
I
T
--
P
--
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
-------
I
T
G
L
P
A
V
D
E
H
R
E
P
-----------------------------------------------------------------------------------------
340
Blastp_CBE
32.29
33%
-35
- C1 -
-
4XS2
6.6
-
IRAK4_HUMAN
B:
[32-234]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
-
T
V
A
V
K
KLA-------------
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
---
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
----
D
L
C
-
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-------
L
D
G
T
P
P
L
SWHMRC
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
H
---
H
---------------
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
----
A
----
A
Q
V
M
R
I
V
G
T
T
---
A
Y
M
A
P
E
A
L
------
R
G
E
I
T
--
P
--
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
-------
I
T
G
L
P
A
V
D
E
H
R
E
P
-----------------------------------------------------------------------------------------
328
Blastp_CBE
32.27
33%
-38
- C1 -
-
4ZTL
6.7
-
IRAK4_HUMAN
B:
[32-234]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
G
E
G
--
G
V
V
Y
K
G
Y
V
N
N
--
T
-
T
V
A
V
K
KLA--------------------
E
I
K
V
M
A
K
C
Q
---
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
----
D
L
C
-
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-------
L
D
G
T
P
P
L
SWHMRC
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
H
---
H
---------------
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
----
A
----
A
Q
V
M
R
I
V
G
T
T
---
A
Y
M
A
P
E
A
L
------
R
G
E
I
T
--
P
--
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
-------
I
T
G
L
P
A
V
D
E
H
R
E
P
-----------------------------------------------------------------------------------------
345
Blastp_CBE
32.18
33%
-19
- C1 -
-
2OID
4.1
-
IRAK4_HUMAN
A:
[31-234]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
-
T
V
A
V
K
K----------------------
E
I
K
V
M
A
K
C
Q
---
H
E
N
L
V
E
L
L
G
F
S
----------
C
-
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-------
L
D
G
T
P
P
L
SWHMRC
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
H
---
H
---------------
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
----
A
S
E
K
-
A
Q
V
M
R
I
V
G
T
T
---
A
Y
M
A
P
E
A
L
------
R
G
E
I
T
--
P
--
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
-------
I
T
G
L
P
A
V
D
E
H
R
E
P
-----------------------------------------------------------------------------------------
396
Blastp_CBE
31.88
33%
-18
- C1 -
-
6O95
7.2
-
IRAK4_HUMAN
A:
[48-250]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
-
T
V
A
V
K
KLAAM
V
D
I
T
T
----
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
---
H
E
N
L
V
E
L
L
G
F
S
S
--
D
----
D
L
C
-
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-------
L
D
G
T
P
P
L
SWHMRC
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
H
---
H
---------------
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
----
A
S
E
K
F
A
Q
--
R
I
V
G
T
T
---
A
Y
M
A
P
E
A
L
------
R
G
E
I
T
--
P
--
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
-------
I
T
G
L
P
A
V
D
E
H
R
E
P
-----------------------------------------------------------------------------------------
347
Blastp_CBE
31.80
33%
-9
- C1 -
-
2OIC
8.2
-
IRAK4_HUMAN
C:
[32-234]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
-
T
V
A
V
K
KL------------
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
---
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
----
D
L
C
-
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-------
L
D
G
T
P
P
L
SWHMRC
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
H
---
H
---------------
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
----
A
S
-------
R
I
V
G
T
T
---
A
Y
M
A
P
E
A
L
------
R
G
E
I
T
--
P
--
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
-------
I
T
G
L
P
A
V
D
E
H
R
E
P
-----------------------------------------------------------------------------------------
295
Blastp_CBE
31.53
33%
-12
- C1 -
-
6MOM
7.6
-
?
D:
[34-236]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
-
T
V
A
V
K
KLAAM
V
D
I
T
T
----
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
---
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
----
D
L
C
-
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-------
L
D
G
T
P
P
L
SWHMRC
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
H
---
H
---------------
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
----
A
S
E
K
F
A
Q
V
M
R
I
V
G
T
T
---
A
Y
M
A
P
E
A
L
------
R
G
E
I
T
--
P
--
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
-------
I
T
G
L
P
A
V
D
E
H
R
E
P
-----------------------------------------------------------------------------------------
428
Blastp_CBE
31.41
33%
-33
- C1 -
-
6F3I
5.8
-
IRAK4_HUMAN
A:
[53-255]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
G
E
----
V
V
Y
K
G
Y
V
----
T
-
T
V
A
V
K
KL--------------
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
---
H
E
N
L
V
E
L
L
G
F
S
----------
C
-
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-------
L
D
G
T
P
P
L
SWHMRC
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
H
---
H
---------------
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
RAS------
T
----
V
M
R
I
-------
V
G
T
T
---
A
Y
M
A
P
E
A
L
------
R
G
E
I
T
--
P
--
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
-------
I
T
G
L
P
A
V
D
E
H
R
E
P
-----------------------------------------------------------------------------------------
352
Blastp_CBE
31.38
33%
-15
- C1 -
-
6N8G
8.5
-
IRAK4_HUMAN
B:
[28-230]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
-
T
V
A
V
K
KLA-----
T
T
----
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
---
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
----
D
L
C
-
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-------
L
D
G
T
P
P
L
SWHMRC
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
H
---
H
---------------
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
----
A
S
E
K
F
A
Q
--
R
I
V
G
T
T
---
A
Y
M
A
P
E
A
L
------
R
G
E
I
T
--
P
--
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
-------
I
T
G
L
P
A
V
D
E
H
R
E
P
-----------------------------------------------------------------------------------------
359
Blastp_CBE
31.36
33%
-23
- C1 -
-
6F3E
7.0
-
IRAK4_HUMAN
A:
[28-230]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
-
T
V
A
V
K
KL--------------
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
---
H
E
N
L
V
E
L
L
G
F
S
---------
L
C
-
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-------
L
D
G
T
P
P
L
SWHMRC
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
H
---
H
---------------
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
--------
R
A
----------
V
M
S
R
I
V
G
T
T
---
A
Y
M
A
P
E
A
L
------
R
G
E
I
T
--
P
--
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
-------
I
T
G
L
P
A
V
D
E
H
R
E
P
-----------------------------------------------------------------------------------------
287
Blastp_CBE
31.21
33%
-11
- C1 -
-
2NRY
7.7
-
IRAK4_HUMAN
D:
[38-240]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
-
T
V
A
V
K
KL-------------
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
---
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
----
D
L
C
-
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-------
L
D
G
T
P
P
L
SWHMRC
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
H
---
H
---------------
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---
R
A
S
E
---------
T
V
---
M
S
R
I
V
G
T
T
---
A
Y
M
A
P
E
A
L
------
R
G
E
I
T
--
P
--
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
-------
I
T
G
L
P
A
V
D
E
H
R
E
P
-----------------------------------------------------------------------------------------
339
Blastp_CBE
31.11
33%
-16
- C1 -
-
4XS2
7.4
-
IRAK4_HUMAN
C:
[32-234]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
-
T
V
A
V
K
KL------
T
T
----
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
---
H
E
N
L
V
E
L
L
G
F
S
S
--------
L
C
-
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-------
L
D
G
T
P
P
L
SWHMRC
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
H
---
H
---------------
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
----
A
S
E
K
-
A
Q
V
M
R
I
V
G
T
T
---
A
Y
M
A
P
E
A
L
------
R
G
E
I
T
--
P
--
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
-------
I
T
G
L
P
A
V
D
E
H
R
E
P
-----------------------------------------------------------------------------------------
338
Blastp_CBE
31.05
33%
-25
- C1 -
-
4XS2
6.9
-
IRAK4_HUMAN
D:
[32-234]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
G
E
G
--
G
V
V
Y
K
G
Y
V
N
N
--
T
-
T
V
A
V
K
KLAA----------
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
---
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
----
D
L
C
-
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-------
L
D
G
T
P
P
L
SWHMRC
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
H
---
H
---------------
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
----
A
S
E
K
F
A
Q
--
R
I
V
G
T
T
---
A
Y
M
A
P
E
A
L
------
R
G
E
I
T
--
P
--
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
-------
I
T
G
L
P
A
V
D
E
H
R
E
P
-----------------------------------------------------------------------------------------
418
Blastp_CBE
30.82
33%
5
- C1 -
-
6EGF
5.3
-
IRAK4_HUMAN
B:
[33-235]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
-
T
V
A
V
K
KLAAM
V
D
I
T
T
----
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
---
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
----
D
L
C
-
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-------
L
D
G
T
P
P
L
SWHMRC
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
H
---
H
---------------
I
H
R
N
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---
R
A
---
S
E
----
K
------------
T
T
---
A
Y
M
A
P
E
A
L
------
R
G
E
I
T
--
P
--
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
-------
I
T
G
L
P
A
V
D
E
H
R
E
P
-----------------------------------------------------------------------------------------
342
Blastp_CBE
30.72
33%
-13
- C1 -
-
2OID
5.4
-
IRAK4_HUMAN
D:
[32-234]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
G
E
G
-
F
G
V
V
Y
K
G
Y
V
N
N
--
T
-
T
V
A
V
K
KL-------------------
D
Q
E
I
K
V
M
A
K
C
Q
---
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
----
D
L
C
-
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-------
L
D
G
T
P
P
L
SWHMRC
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
H
---
H
---------------
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
----
A
S
E
K
F
A
Q
V
M
R
I
V
G
T
T
---
A
Y
M
A
P
E
A
L
------
R
G
E
I
T
--
P
--
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
-------
I
T
G
L
P
A
V
D
E
H
R
E
P
-----------------------------------------------------------------------------------------
341
Blastp_CBE
30.68
33%
-16
- C1 -
-
4XS2
6.5
-
IRAK4_HUMAN
A:
[32-234]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
-
T
V
A
V
K
KLA-----
T
T
----
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
---
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
----
D
L
C
-
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-------
L
D
G
T
P
P
L
SWHMRC
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
H
---
H
---------------
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
----
A
S
E
K
-
A
Q
V
M
R
I
V
G
T
T
---
A
Y
M
A
P
E
A
L
------
R
G
E
I
T
--
P
--
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
-------
I
T
G
L
P
A
V
D
E
H
R
E
P
-----------------------------------------------------------------------------------------
313
Blastp_CBE
30.47
33%
-10
- C1 -
-
5KX8
5.3
-
IRAK4_HUMAN
D:
[32-234]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
-
T
V
A
V
K
KLA-----
T
T
----
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
---
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
----
D
L
C
-
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-------
L
D
G
T
P
P
L
SWHMRC
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
H
---
H
---------------
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
----
A
S
E
K
F
A
Q
--
R
I
V
G
T
T
---
A
Y
M
A
P
E
A
L
------
R
G
E
I
T
--
P
--
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
-------
I
T
G
L
P
A
V
D
E
H
R
E
P
-----------------------------------------------------------------------------------------
390
Blastp_CBE
30.29
33%
-4
- C1 -
-
6O9D
7.2
-
IRAK4_HUMAN
C:
[48-250]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
-
T
V
A
V
K
KL------
T
T
----
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
---
H
E
N
L
V
E
L
L
G
F
S
S
--
D
----
D
L
C
-
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-------
L
D
G
T
P
P
L
SWHMRC
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
H
---
H
---------------
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
----
A
S
E
K
F
A
Q
--
R
I
V
G
T
T
---
A
Y
M
A
P
E
A
L
------
R
G
E
I
T
--
P
--
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
-------
I
T
G
L
P
A
V
D
E
H
R
E
P
-----------------------------------------------------------------------------------------
304
Blastp_CBE
30.25
33%
-6
- C1 -
-
4Y73
7.1
-
IRAK4_HUMAN
A:
[33-235]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
-
T
V
A
V
K
KLAAM
V
D
I
T
T
----
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
---
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
----
D
L
C
-
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-------
L
D
G
T
P
P
L
SWHMRC
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
H
---
H
---------------
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
----
A
S
E
K
F
A
Q
--
R
I
V
G
T
T
---
A
Y
M
A
P
E
A
L
------
R
G
E
I
T
--
P
--
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
-------
I
T
G
L
P
A
V
D
E
H
R
E
P
-----------------------------------------------------------------------------------------
426
Blastp_CBE
28.61
33%
-16
- C1 -
-
6RFI
6.6
-
?
A:
[53-255]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
G
E
G
--
G
V
V
Y
K
G
Y
V
N
N
--
T
-
T
V
A
V
K
KL------------
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
---
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
----
D
L
C
-
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-------
L
D
G
T
P
P
L
SWHMRC
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
H
---
H
---------------
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
R-----
A
-
Q
T
----
V
M
R
I
-------
V
G
T
T
---
A
Y
M
A
P
E
A
L
------
R
G
E
I
T
--
P
--
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
-------
I
T
G
L
P
A
V
D
E
H
R
E
P
-----------------------------------------------------------------------------------------