@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Screening
Virtual Screening Score
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : BMX_HUMAN: (2020-09-05 )
MDTKSILEELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYDKMKRGSRKGSIEIKKIRCVEKVNLEEQTPVERQYPFQIVYKDGLLYVYASNEESRSQWLKALQKEIRGNPHLLVKYHSGFFVDGKFLCCQQSCKAAPGCTLWEAYANLHTAVNEEKHRVPTFPDRVLKIPRAVPVLKMDAPSSSTTLAQYDNESKKNYGSQPPSSSTSLAQYDSNSKKIYGSQPNFNMQYIPREDFPDWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFAGNISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRPTFQQLLSSIEPLREKDKH
Atome Classification :
(513 SA)
.........10........20........30........40...--.....50........60........70..------------......80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.....-..230.......240......-.-250.......260.......270.......280.......290.......300.....-..310-.-.-......320..-..-.-..330.......340..-.....350.......360.......370.......380.......390.......400-----...---------------.----------------...--410-------.....--------.-.420.......430....------.----.---.440-........450--.---..---....-460.......470.......480..-.....490.......500-.--.--.-..-..510........520.......530.......540.......550.......560.....--..570..-......580.......590.......600.......610.-......620.......630.......640.......650.......660.......670...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(pKd)
(pKd)
(Uniprot)
M
D
T
K
S
I
L
E
E
L
L
L
K
R
S
Q
Q
KKKMSPNNY
K
E
R
L
F
V
L
TKTNL
S
Y
Y
E
Y
D
--
K
MKRGSRKG
S
I
E
I
K
K
I
R
C
V
E
KVNLEEQTP------------VERQY
P
F
Q
I
V
YKD
G
L
L
Y
V
Y
ASN
E
E
S
R
S
Q
W
L
K
A
L
Q
K
E
IRGNP
H
L
L
V
K
YHS
G
F
F
VDG
K
F
L
C
C
Q
Q
SCKAAPG
C
T
L
W
E
A
Y
A
N
L
H
T
AVNEEKHRVPTF
P
D
R
V
LKIPRAV
P
V
L
K
MDAPSSS
T
T
L
A
QYDNESKKNYGSQPPSSSTS
L
A
QYDSNS
K
K
I
YGSQ-PNF
N
M
Q
YIPREDFP
D
W
W
Q
V
R
K
-L-KSSSSSEDVASSNQKERNVNHTTS
K
I
S
W
EFPESSSSEEEENLDDYDWFAGNIS
R
S
Q
S
E
-
Q
L
L
-
R
-Q-K-GKE
G
A
F
M
V
RNS-SQ-V-
G
M
Y
T
V
S
L
F
S
K
A
VNDKKG-
T
V
K
H
Y
H
V
HTNAE
N
K
L
Y
L
AEN
Y
C
F
D
S
I
P
K
L
I
H
Y
HQHNSAG
M
I
T
R
LRHPVSTKANKVPDS-----VSL---------------G----------------N
G
I
--
W
E
L
-------
K
R
E
E
I
--------
T
-
L
L
K
E
LGSG
Q
F
G
V
V
Q
LGKW------K----G---Q
Y
-
D
-
V
A
V
K
M
I
KEGSM--
S
---
E
D
---
E
F
F
Q
-
E
A
Q
T
M
M
KLSH
P
K
L
V
K
F
Y
G
VCSKEY
P
-
I
Y
I
V
T
E
Y
ISN
G
C
L
L
N
Y
L
R
-S--H--G-KG-L
E
P
-
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
RNCLVDRD
L
C
V
K
VSDFG
M
T
R
Y
V
L
D
D
Q
Y
V
--
S
S
V-GTK-FPVKWSAPE
V
F
H
Y
F
KYSSKS
D
V
W
A
F
G
I
L
M
W
E
V
F
S
LGKQPY-DLYDN
S
Q
V
V
L
K
VSQG
H
R
LYRPHLAS
D
T
I
Y
Q
I
M
Y
S
C
W
H
ELPEKR
P
T
F
Q
Q
L
L
S
S
I
E
P
L
R
EKDKH
3
PsiBlast_PDB
84.85
59%
-138
- C1 -
-
4XI2
-
-
BTK_MOUSE
A:
[51-438]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
S
N
Y
I
T
E
A
E
D
S
I
E
M
Y
E
W
Y
S
K
H
M
T
R
S
Q
A
E
-
Q
L
L
---------
E
G
G
F
I
V
R
D
---------
Y
T
V
S
V
F
A
K
------
G
-
V
I
R
H
Y
V
V
C
------
Y
Y
L
A
E
K
H
L
F
S
T
I
P
E
L
I
N
Y
H
Q
H
N
S
A
G
L
I
S
R
L
K
Y
P
V
S
K
Q
N
K
N
A
P
S
T
-----
A
G
L
---------------
G
----------------
Y
G
S
--
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
R
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
R
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
S
F
K
I
L
L
S
N
I
---------
2
PsiBlast_PDB
81.34
97%
-134
- C1 -
-
3SXS
7.3
-
A:
[1-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
--
M
E
L
-------
K
R
E
E
I
--------
T
-
L
L
K
E
L
G
S
G
Q
F
G
V
V
K
L
G
K
W
------
K
----
G
---
Q
Y
-
D
-
V
A
V
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
F
Q
-
E
A
Q
T
M
M
K
L
S
H
P
K
L
V
K
F
Y
G
V
C
S
K
E
Y
P
-
I
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
-
S
--
H
--
G
-
K
G
-
L
E
P
-
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
D
R
D
L
C
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
D
Q
Y
V
--
S
S
V
-
G
T
K
-
F
P
V
K
W
S
A
P
E
V
F
H
Y
F
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
-
D
L
Y
T
N
S
E
V
V
L
K
V
S
Q
G
H
R
L
Y
R
P
H
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
E
P
L
R
E
----
550
HHSearch
80.80
59%
9
- C1 -
-
4Y93
9.4
-
?
A:
[2-445]
-
M
A
T
V
I
L
E
S
I
F
L
K
R
S
--------
L
N
F
K
K
R
L
F
L
L
T
V
Q
K
L
S
Y
Y
E
Y
D
FE
R
G
R
R
G
S
K
K
G
S
I
D
V
E
K
I
T
C
V
E
T
V
V
P
E
K
N
P
P
PERQIPEQISII
E
R
F
P
Y
P
F
Q
V
V
Y
D
E
G
P
L
Y
V
F
S
P
T
E
E
L
R
K
R
W
I
H
Q
L
K
N
V
I
R
Y
N
S
D
L
V
Q
K
Y
H
P
C
F
W
I
D
G
Q
Y
L
C
C
S
Q
T
A
K
N
A
M
G
C
Q
I
L
A
A
A
P
-------------------------------------------------
S
----------------------------------------
T
--------------
A
---
G
---
L
G
--------------------
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
--
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
D
E
Y
T
--
S
S
T
-
G
S
K
-
F
P
V
K
W
A
S
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
P
R
P
H
L
A
S
E
R
V
Y
A
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
---
21
Blastp_CBE
79.54
98%
-133
- C1 -
-
3SXR
8.0
-
B:
[1-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
--
M
E
L
-------
K
R
E
E
I
--------
T
-
L
L
K
E
L
------
V
V
K
L
G
K
W
------
K
----
G
---
Q
Y
-
D
-
V
A
V
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
F
Q
-
E
A
Q
T
M
M
K
L
S
H
P
K
L
V
K
F
Y
G
V
C
S
K
E
Y
P
-
I
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
-
S
--
H
--
G
-
K
G
-
L
E
P
-
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
D
R
D
L
C
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
D
Q
Y
V
--
S
S
V
-
G
T
K
-
F
P
V
K
W
S
A
P
E
V
F
H
Y
F
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
-
D
L
Y
T
N
S
E
V
V
L
K
V
S
Q
G
H
R
L
Y
R
P
H
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
E
P
L
R
E
----
1
PsiBlast_PDB
79.41
97%
-129
- C1 -
-
3SXR
8.2
-
BMX_HUMAN
A:
[1-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
--
M
E
L
-------
K
R
E
E
I
--------
T
-
L
L
K
E
L
G
S
----
V
V
K
L
G
K
W
------
K
----
G
---
Q
Y
-
D
-
V
A
V
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
F
Q
-
E
A
Q
T
M
M
K
L
S
H
P
K
L
V
K
F
Y
G
V
C
S
K
E
Y
P
-
I
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
-
S
--
H
--
G
-
K
G
-
L
E
P
-
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
D
R
D
L
C
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
D
Q
Y
V
--
S
S
V
-
G
T
K
-
F
P
V
K
W
S
A
P
E
V
F
H
Y
F
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
-
D
L
Y
T
N
S
E
V
V
L
K
V
S
Q
G
H
R
L
Y
R
P
H
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
E
P
L
R
E
----
539
HHSearch
76.43
54%
-15
- C1 -
-
4XI2
-
-
BTK_MOUSE
A:
[3-444]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
K
V
V
A
L
Y
D
Y
M
P
M
N
A
N
D
L
Q
L
R
K
G
E
E
Y
F
I
L
E
E
S
N
L
P
W
W
R
A
R
D
-
K
-
N
G
Q
E
---
G
Y
I
P
S
N
--------------------
Y
I
T
E
A
E
D
S
I
E
M
Y
E
W
Y
S
K
H
M
T
R
S
Q
A
E
-
Q
L
L
---------
E
G
G
F
I
V
R
D
---------
Y
T
V
S
V
F
A
K
------
G
-
V
I
R
H
Y
V
V
C
------
Y
Y
L
A
E
K
H
L
F
S
T
I
P
E
L
I
N
Y
H
Q
H
N
S
A
G
L
I
S
R
L
K
Y
P
V
S
K
Q
N
K
N
A
P
S
T
-----
A
G
L
---------------
G
----------------
Y
G
S
--
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
R
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
R
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
S
F
K
I
L
L
S
N
I
L
D
V
M
D
E
---
104
Blastp_CBE
72.47
58%
-144
- C1 -
-
4HCU
8.8
-
A:
[5-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
I
-------
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
R
E
G
A
M
--
S
---
E
E
---
D
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
Y
T
--
S
S
T
-
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----
46
Blastp_CBE
72.39
66%
-150
- C1 -
-
6DI5
7.2
-
A:
[1-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
---------------
G
----------------
Y
G
S
--
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
105
Blastp_CBE
72.36
58%
-143
- C1 -
-
4HCT
9.2
-
A:
[3-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
--
W
V
I
-------
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
R
E
G
A
M
--
S
---
E
E
---
D
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
Y
T
--
S
S
T
-
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----
99
Blastp_CBE
72.36
58%
-145
- C1 -
-
4M13
9.7
-
A:
[4-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
W
V
I
-------
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
R
E
G
A
M
--
S
---
E
E
---
D
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
Y
T
--
S
S
T
-
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----
42
Blastp_CBE
71.98
66%
-141
- C1 -
-
6OMU
6.6
-
A:
[1-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
---------------
G
----------------
Y
G
S
--
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
98
Blastp_CBE
71.82
58%
-143
- C1 -
-
4M14
8.7
-
A:
[4-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
W
V
I
-------
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
R
E
G
A
M
--
S
---
E
E
---
D
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
Y
T
--
S
S
T
-
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----
97
Blastp_CBE
71.56
58%
-143
- C1 -
-
4M15
4.9
-
A:
[4-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
W
V
I
-------
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
R
E
G
A
M
--
S
---
E
E
---
D
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
Y
T
--
S
S
T
-
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----
49
Blastp_CBE
71.53
66%
-140
- C1 -
-
6DI0
4.2
-
A:
[1-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
---------------
G
----------------
Y
G
S
--
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
50
Blastp_CBE
71.51
66%
-143
- C1 -
-
5VFI
10.9
-
A:
[1-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
---------------
G
----------------
Y
G
S
--
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
103
Blastp_CBE
71.48
58%
-145
- C1 -
-
4HCV
8.7
-
A:
[5-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
I
-------
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
R
E
G
A
M
--
S
---
E
E
---
D
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
Y
T
--
S
S
T
-
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----
102
Blastp_CBE
71.47
58%
-143
- C1 -
-
4M0Y
7.9
-
A:
[5-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
I
-------
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
R
E
G
A
M
--
S
---
E
E
---
D
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
Y
T
--
S
S
T
-
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----
58
Blastp_CBE
71.45
66%
-145
- C1 -
-
6J6M
8.2
-
?
A:
[3-261]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
--
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
55
Blastp_CBE
71.43
66%
-138
- C1 -
-
6E4F
8.9
-
A:
[20-282]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
---------------
G
----------------
Y
G
S
--
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
101
Blastp_CBE
71.41
58%
-143
- C1 -
-
4M0Z
5.3
-
A:
[4-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
W
V
I
-------
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
R
E
G
A
M
--
S
---
E
E
---
D
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
Y
T
--
S
S
T
-
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----
16
PsiBlast_PDB
71.36
64%
-145
- C1 -
-
5BQ0
7.3
-
A:
[13-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
---------------
G
----------------
Y
G
S
--
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
---------
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
61
Blastp_CBE
71.32
66%
-143
- C1 -
-
6S90
10.4
-
BTK_HUMAN
A:
[3-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
100
Blastp_CBE
71.29
58%
-140
- C1 -
-
4M12
9.2
-
A:
[4-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
W
V
I
-------
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
R
E
G
A
M
--
S
---
E
E
---
D
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
Y
T
--
S
S
T
-
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----
75
Blastp_CBE
71.27
65%
-142
- C1 -
-
4Y93
9.4
-
?
A:
[172-439]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
S
T
-----
A
G
L
---------------
G
----------------
Y
G
S
--
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
D
E
Y
T
--
S
S
T
-
G
S
K
-
F
P
V
K
W
A
S
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
P
R
P
H
L
A
S
E
R
V
Y
A
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
43
Blastp_CBE
71.15
66%
-137
- C1 -
-
6NFH
7.2
-
A:
[1-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
---------------
G
----------------
Y
G
S
--
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
65
Blastp_CBE
71.13
66%
-143
- C1 -
-
5KUP
10.2
-
A:
[3-260]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
23
Blastp_CBE
71.13
65%
-133
- C1 -
-
4YHF
6.7
-
B:
[9-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------------
G
----------------
Y
G
S
--
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
44
Blastp_CBE
71.11
66%
-143
- C1 -
-
6N9P
6.7
-
A:
[1-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
---------------
G
----------------
Y
G
S
--
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
26
Blastp_CBE
71.10
65%
-136
- C1 -
-
5P9K
6.6
-
A:
[9-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
---------------
G
----------------
Y
G
S
--
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
87
Blastp_CBE
71.09
66%
-145
- C1 -
-
5BPY
7.6
-
BTK_HUMAN
A:
[3-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
60
Blastp_CBE
71.03
66%
-140
- C1 -
-
6S90
10.6
-
B:
[3-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
66
Blastp_CBE
70.99
66%
-144
- C1 -
-
4RX5
8.5
-
A:
[3-260]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
96
Blastp_CBE
70.97
59%
-143
- C1 -
-
3T9T
6.6
-
A:
[3-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
I
-------
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
R
E
G
A
M
--
S
---
E
E
---
D
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
T
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
Y
T
--
S
S
T
-
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----
27
Blastp_CBE
70.96
65%
-146
- C1 -
-
5P9J
8.8
-
A:
[14-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
------
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
31
Blastp_CBE
70.87
66%
-133
- C1 -
-
5J87
9.6
-
BTK_HUMAN
B:
[1-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
T
-----
A
G
L
---------------
G
----------------
Y
G
S
--
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
57
Blastp_CBE
70.86
66%
-136
- C1 -
-
4ZLY
4.2
-
A:
[1-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
---------------
G
----------------
Y
G
S
--
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
51
Blastp_CBE
70.74
66%
-137
- C1 -
-
5U9D
10.2
-
A:
[1-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
---------------
G
----------------
Y
G
S
--
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
64
Blastp_CBE
70.72
66%
-143
- C1 -
-
5VGO
10.0
-
A:
[3-260]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
33
Blastp_CBE
70.52
65%
-138
- C1 -
-
4Z3V
6.8
-
A:
[13-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
---------------
G
----------------
Y
G
S
--
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
40
Blastp_CBE
70.50
66%
-138
- C1 -
-
3PIX
5.7
-
A:
[6-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
----------------
Y
G
S
--
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
82
Blastp_CBE
70.42
66%
-142
- C1 -
-
6AUA
9.5
-
A:
[2-258]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
A
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
48
Blastp_CBE
70.39
66%
-139
- C1 -
-
6DI1
3.9
-
A:
[1-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
---------------
G
----------------
Y
G
S
--
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
15
PsiBlast_PDB
70.30
64%
-146
- C1 -
-
3GEN
8.7
-
A:
[16-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
--
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
---
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
85
Blastp_CBE
70.12
66%
-144
- C1 -
-
5JRS
9.2
-
BTK_HUMAN
A:
[3-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
----------
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
90
Blastp_CBE
70.11
66%
-140
- C1 -
-
6BKW
8.9
-
A:
[2-260]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
--
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
-
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
24
Blastp_CBE
70.08
65%
-140
- C1 -
-
5P9M
7.3
-
A:
[9-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
---------------
G
----------------
Y
G
S
--
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
17
PsiBlast_PDB
70.04
65%
-138
- C1 -
-
4YHF
7.3
-
BTK_HUMAN
A:
[10-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
----------------
Y
G
S
--
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
83
Blastp_CBE
70.03
66%
-141
- C1 -
-
5T18
9.1
-
A:
[2-259]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
--
M
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
----------
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
74
Blastp_CBE
70.01
66%
-142
- C1 -
-
3OCS
9.8
-
A:
[4-260]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
28
Blastp_CBE
69.99
65%
-140
- C1 -
-
5P9I
9.1
-
A:
[9-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
---------------
G
----------------
Y
G
S
--
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
5
PsiBlast_PDB
69.96
64%
-145
- C1 -
-
4OT6
7.0
-
A:
[18-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
A
--
R
-
H
A
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
18
PsiBlast_PDB
69.94
64%
-142
- C1 -
-
5P9F
10.2
-
A:
[14-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
76
Blastp_CBE
69.91
67%
-142
- C1 -
-
6AUB
9.8
-
A:
[1-257]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
59
Blastp_CBE
69.90
66%
-144
- C1 -
-
6O8I
5.4
-
A:
[1-261]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
----------------
Y
G
S
--
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
----------------
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
19
PsiBlast_PDB
69.84
64%
-144
- C1 -
-
5P9G
10.3
-
A:
[14-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
47
Blastp_CBE
69.79
66%
-150
- C1 -
-
6DI3
7.0
-
A:
[5-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
--
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
--
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
------------
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
4
PsiBlast_PDB
69.78
64%
-142
- C1 -
-
4OT5
10.3
-
A:
[20-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
A
--
R
-
H
A
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
56
Blastp_CBE
69.75
66%
-138
- C1 -
-
4ZLZ
5.4
-
A:
[1-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
---------------
G
----------------
Y
G
S
--
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
20
PsiBlast_PDB
69.75
64%
-149
- C1 -
-
5P9H
8.8
-
A:
[15-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
22
Blastp_CBE
69.69
65%
-143
- C1 -
-
6NZM
10.1
-
D:
[16-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
9
PsiBlast_PDB
69.57
64%
-142
- C1 -
-
4RFZ
10.0
-
A:
[20-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
A
--
R
-
H
A
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
30
Blastp_CBE
69.54
66%
-139
- C1 -
-
5J87
9.3
-
BTK_HUMAN
C:
[12-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
14
PsiBlast_PDB
69.54
64%
-143
- C1 -
-
6NZM
10.1
-
BTK_HUMAN
A:
[16-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
---
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
12
PsiBlast_PDB
69.51
64%
-140
- C1 -
-
6HRP
10.3
-
A:
[20-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
A
--
R
-
H
A
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
8
PsiBlast_PDB
69.51
64%
-146
- C1 -
-
4RFY
9.6
-
A:
[20-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
A
--
R
-
H
A
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
6
PsiBlast_PDB
69.51
64%
-142
- C1 -
-
4OTQ
9.7
-
A:
[20-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
A
--
R
-
H
A
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
52
Blastp_CBE
69.46
66%
-156
- C1 -
-
5FBO
10.5
-
A:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
--
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-----------------
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
395
Blastp_CBE
69.41
37%
-36
- C1 -
-
6JMF
6.6
-
A:
[3-374]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
Q
K
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
-
E
L
L
-
V
-
H
-
S
-
G
D
---
F
L
V
R
E
S
-
Q
G
-
K
-
Q
E
Y
V
L
S
V
L
W
D
------
G
-
L
P
R
H
F
I
I
Q
S
L
--
D
N
L
Y
R
L
E
G
E
G
F
P
S
I
P
L
L
I
D
H
--------
L
L
S
T
Q
Q
P
L
T
K
K
S
G
V
V
L
H
R
------
A
V
---------------
P
----------------
K
D
K
--
W
V
L
-------
N
H
E
D
L
--------
V
-
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
------
R
----
A
---
D
N
-
T
L
V
A
V
K
S
C
R
E
-
T
L
--
P
---
P
D
LKA
K
F
L
Q
-
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
Q
P
-
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
-
T
--
E
--
G
-
A
R
-
L
R
V
-
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
--
A
S
G
-
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
-
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
H
--
89
Blastp_CBE
69.37
66%
-139
- C1 -
-
6BLN
8.5
-
A:
[4-260]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
-
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
11
PsiBlast_PDB
69.37
64%
-144
- C1 -
-
6EP9
9.9
-
A:
[20-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
A
--
R
-
H
A
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
13
PsiBlast_PDB
69.33
64%
-140
- C1 -
-
6HRT
11.4
-
A:
[20-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
A
--
R
-
H
A
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
10
PsiBlast_PDB
69.28
64%
-143
- C1 -
-
4RG0
10.6
-
A:
[20-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
A
--
R
-
H
A
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
92
Blastp_CBE
69.22
66%
-139
- C1 -
-
6BKE
9.3
-
A:
[4-260]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
-
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
32
Blastp_CBE
69.17
66%
-142
- C1 -
-
5J87
9.6
-
BTK_HUMAN
A:
[12-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
7
PsiBlast_PDB
69.16
64%
-142
- C1 -
-
4OTR
10.3
-
A:
[20-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
A
--
R
-
H
A
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
93
Blastp_CBE
69.03
66%
-138
- C1 -
-
6BIK
9.4
-
A:
[4-260]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
-
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
430
Blastp_CBE
69.01
37%
-34
- C1 -
-
3BKB
8.7
-
A:
[5-376]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
Q
K
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
-
E
L
L
-
V
-
H
-
S
-
G
D
---
F
L
V
R
E
S
-
Q
G
-
K
-
Q
E
Y
V
L
S
V
L
W
D
------
G
-
L
P
R
H
F
I
I
Q
S
L
--
D
N
L
Y
R
L
E
G
E
G
F
P
S
I
P
L
L
I
D
H
--------
L
L
S
T
Q
Q
P
L
T
K
K
S
G
V
V
L
H
R
------
A
V
---------------
P
----------------
K
D
K
--
W
V
L
-------
N
H
E
D
L
--------
V
-
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
------
R
----
A
---
D
N
-
T
L
V
A
V
K
S
C
R
E
-
T
L
--
P
---
P
D
LKA
K
F
L
Q
-
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
Q
P
-
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
-
T
--
E
--
G
-
A
R
-
L
R
V
-
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
--
A
S
G
-
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
-
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
H
--
81
Blastp_CBE
68.86
66%
-160
- C1 -
-
3OCT
8.7
-
A:
[3-260]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
--
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
---
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
29
Blastp_CBE
68.81
66%
-140
- C1 -
-
5J87
8.2
-
D:
[12-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
36
Blastp_CBE
68.76
66%
-157
- C1 -
-
3PJ2
7.8
-
A:
[6-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
----------------
Y
G
S
--
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
---
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
----------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
551
HHSearch
68.72
38%
-50
- C1 -
-
6JMF
6.6
-
A:
[6-373]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
-
E
L
L
-
V
------
H
S
G
D
F
L
V
R
E
S
-
Q
G
-
K
-
Q
E
Y
V
L
S
V
L
W
D
------
G
-
L
P
R
H
F
I
I
Q
S
-
L
D
N
L
Y
R
L
-
E
G
E
G
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
P
L
T
K
K
S
G
V
V
L
H
--------------
R
A
V
---------------
P
----------------
K
D
K
--
W
V
L
-------
N
H
E
D
L
--------
V
-
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
------
R
----
A
D--
N
T
-
L
-
V
A
V
K
S
C
R
E
T
L
P
PD
L
---
K
A
---
K
F
L
Q
-
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
Q
P
-
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
-
T
--
E
--
G
-
A
R
-
L
R
V
-
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
--
A
S
G
G
L
R
Q
-
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
-
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
---
552
HHSearch
68.63
38%
-46
- C1 -
-
3BKB
8.7
-
A:
[7-375]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
-
E
L
L
-
V
------
H
S
G
D
F
L
V
R
E
S
-
Q
G
-
K
-
Q
E
Y
V
L
S
V
L
W
D
------
G
-
L
P
R
H
F
I
I
Q
S
-
L
D
N
L
Y
R
L
-
E
G
E
G
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
P
L
T
K
K
S
G
V
V
L
H
--------------
R
A
V
---------------
P
----------------
K
D
K
--
W
V
L
-------
N
H
E
D
L
--------
V
-
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
------
R
----
A
D--
N
T
-
L
-
V
A
V
K
S
C
R
E
T
L
P
PD
L
---
K
A
---
K
F
L
Q
-
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
Q
P
-
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
-
T
--
E
--
G
-
A
R
-
L
R
V
-
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
--
A
S
G
G
L
R
Q
-
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
-
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
---
54
Blastp_CBE
68.58
66%
-150
- C1 -
-
5FBN
7.7
-
BTK_HUMAN
C:
[7-263]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
-----------
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
91
Blastp_CBE
68.54
66%
-137
- C1 -
-
6BKH
9.0
-
A:
[5-260]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
-
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
53
Blastp_CBE
68.52
66%
-149
- C1 -
-
5FBN
11.1
-
D:
[6-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
--------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
34
Blastp_CBE
68.50
65%
-153
- C1 -
-
6MNY
7.6
-
?
A:
[12-268]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
R
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
-------------
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
A
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
R
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
S
F
K
I
L
L
S
N
I
---------
549
HHSearch
68.49
36%
5
- C1 -
-
1OPK
10.4
-
ABL1_MOUSE
A:
[44-479]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
G
Y
N
H
N
G
E
W
C
E
A
Q
-
T
-
K
N
G
Q
---
G
W
V
P
S
N
--------------------
Y
I
T
P
-
V
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
-
Y
L
L
-
S
-
S
---
G
I
N
G
S
F
L
V
R
E
S
-
E
S
S
P
-
G
Q
R
S
I
S
L
R
Y
E
------
G
-
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
K
R
N
K
P
T
I
Y
G
-----
V
S
P
---------------
N
----------------
Y
D
K
--
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
R
Q
E
-
V
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
---
39
Blastp_CBE
68.42
66%
-135
- C1 -
-
3PIY
7.5
-
A:
[6-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
----------------
Y
G
S
--
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
-----------
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
V
-
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
166
Blastp_CBE
68.34
35%
4
- C1 -
-
5H0G
9.5
-
HCK_HUMAN
A:
[32-440]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
V
V
L
E
E
S
G
E
W
W
K
A
R
S
-
L
---
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
---------------------
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
T
-
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------
W
---------------
E
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
------
N
----
K
---
H
T
-
K
-
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
E
---
A
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
--
D
--
E
-
G
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
Y
T
--
A
R
E
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
-
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------
169
Blastp_CBE
68.29
35%
2
- C1 -
-
5H09
9.9
-
HCK_HUMAN
A:
[32-440]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
V
V
L
E
E
S
G
E
W
W
K
A
R
S
-
L
---
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
---------------------
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
T
-
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------
W
---------------
E
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
------
N
----
K
---
H
T
-
K
-
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
E
---
A
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
--
D
--
E
-
G
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
Y
T
--
A
R
E
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
-
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------
45
Blastp_CBE
68.23
66%
-155
- C1 -
-
6DI9
5.5
-
A:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
--
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
------
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
-------------
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
167
Blastp_CBE
68.09
35%
4
- C1 -
-
5H0E
9.7
-
HCK_HUMAN
A:
[32-440]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
V
V
L
E
E
S
G
E
W
W
K
A
R
S
-
L
---
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
---------------------
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
T
-
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------
W
---------------
E
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
------
N
----
K
---
H
T
-
K
-
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
E
---
A
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
--
D
--
E
-
G
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
Y
T
--
A
R
E
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
-
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------
25
Blastp_CBE
68.00
65%
-152
- C1 -
-
5P9L
5.7
-
A:
[12-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
--
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
----
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
-------------
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
165
Blastp_CBE
67.97
35%
3
- C1 -
-
5H0H
9.8
-
HCK_HUMAN
A:
[32-440]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
V
V
L
E
E
S
G
E
W
W
K
A
R
S
-
L
---
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
---------------------
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
T
-
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------
W
---------------
E
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
------
N
----
K
---
H
T
-
K
-
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
E
---
A
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
--
D
--
E
-
G
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
Y
T
--
A
R
E
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
-
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------
86
Blastp_CBE
67.96
66%
-156
- C1 -
-
5BPY
7.6
-
B:
[3-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
-
G
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-----
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
--------------
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
160
Blastp_CBE
67.87
40%
-21
- C1 -
-
1Y57
7.3
-
SRC_HUMAN
A:
[66-436]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
W
Y
F
G
K
I
T
R
R
E
S
E
-
R
L
L
L
N
-
A
-
E
-
N
P
R
G
T
F
L
V
R
E
S
-
E
T
-
T
K
G
A
Y
C
L
S
V
-
S
D
F
D
N
A
K
G
L
-
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
T
S
K
---
P
Q
T
-----
Q
G
L
---------------
A
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
T-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
Q
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
154
Blastp_CBE
67.77
39%
-18
- C1 -
-
1OPK
10.4
-
ABL1_MOUSE
A:
[101-476]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
-
Y
L
L
---
S
-
S
-
G
I
N
G
S
F
L
V
R
E
S
E
S
S
-
P
-
G
Q
R
S
I
S
L
------
R
Y
E
G
-
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
K
R
N
K
P
T
I
Y
G
-----
V
S
P
---------------
N
----------------
Y
D
K
--
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C-
N
--
R
-
Q
E
-
V
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
84
Blastp_CBE
67.77
66%
-156
- C1 -
-
5JRS
9.0
-
B:
[3-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
--
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-----
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
----------
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
--------------
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
168
Blastp_CBE
67.63
35%
2
- C1 -
-
5H0B
9.9
-
HCK_HUMAN
A:
[32-440]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
V
V
L
E
E
S
G
E
W
W
K
A
R
S
-
L
---
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
---------------------
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
T
-
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------
W
---------------
E
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
------
N
----
K
---
H
T
-
K
-
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
E
---
A
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
--
D
--
E
-
G
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
Y
T
--
A
R
E
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
-
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------
159
Blastp_CBE
67.60
40%
-9
- C1 -
-
2SRC
5.3
-
SRC_HUMAN
A:
[66-436]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
W
Y
F
G
K
I
T
R
R
E
S
E
-
R
L
L
L
N
-
A
-
E
-
N
P
R
G
T
F
L
V
R
E
S
-
E
T
-
T
K
G
A
Y
C
L
S
V
-
S
D
F
D
N
A
K
G
L
-
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
T
S
K
---
P
Q
T
-----
Q
G
L
---------------
A
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
T-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
Q
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
114
Blastp_CBE
67.58
59%
-137
- C1 -
-
3MJ2
6.5
-
A:
[8-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
R
E
G
A
M
--
S
---
E
E
---
D
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
Y
T
--
S
S
T
-
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
------
157
Blastp_CBE
67.34
39%
-19
- C1 -
-
1OPL
10.1
-
ABL1_HUMAN
A:
[140-515]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
-
Y
L
L
---
S
-
S
-
G
I
N
G
S
F
L
V
R
E
S
E
S
S
-
P
-
G
Q
R
S
I
S
L
------
R
Y
E
G
-
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
K
R
N
K
P
T
V
Y
G
-----
V
S
P
---------------
N
----------------
Y
D
K
--
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C-
N
--
R
-
Q
E
-
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
37
Blastp_CBE
67.30
66%
-159
- C1 -
-
3PJ1
7.6
-
A:
[6-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
----------------
Y
G
S
--
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
---
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
-------
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
---
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
-----
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
--------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
109
Blastp_CBE
67.29
61%
-152
- C1 -
-
3QGW
6.2
-
ITK_HUMAN
A:
[28-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
K
E
G
S
M
--
S
---
E
D
---
D
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
---------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----
161
Blastp_CBE
67.26
40%
-10
- C1 -
-
2H8H
8.1
-
SRC_HUMAN
A:
[149-519]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
W
Y
F
G
K
I
T
R
R
E
S
E
-
R
L
L
L
N
-
A
-
E
-
N
P
R
G
T
F
L
V
R
E
S
-
E
T
-
T
K
G
A
Y
C
L
S
V
-
S
D
F
D
N
A
K
G
L
-
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
T
S
K
---
P
Q
T
-----
Q
G
L
---------------
A
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
T-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
Q
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
428
Blastp_CBE
67.24
37%
-43
- C1 -
-
4E93
5.6
-
A:
[5-377]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
Q
K
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
-
E
L
L
-
V
-
H
-
S
-
G
D
---
F
L
V
R
E
S
-
Q
----
Q
E
Y
V
L
S
V
L
W
D
------
G
-
L
P
R
H
F
I
I
Q
S
L
--
D
N
L
Y
R
L
E
G
E
G
F
P
S
I
P
L
L
I
D
H
--------
L
L
S
T
Q
Q
P
L
T
K
K
S
G
V
V
L
H
R
------
A
V
---------------
P
----------------
K
D
K
--
W
V
L
-------
N
H
E
D
L
--------
V
-
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
------
R
----
A
---
D
N
-
T
L
V
A
V
K
S
C
R
E
-
T
L
--
P
---
P
D
LKA
K
F
L
Q
-
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
Q
P
-
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
-
T
--
E
--
G
-
A
R
-
L
R
V
-
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
-----------------
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
-
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
H
R
-
191
Blastp_CBE
67.15
35%
-4
- C1 -
-
3VRZ
8.7
-
HCK_HUMAN
A:
[32-440]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
V
V
L
E
E
S
G
E
W
W
K
A
R
S
-
L
---
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
---------------------
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
T
-
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------
W
---------------
E
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
------
N
----
K
---
H
T
-
K
-
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
E
---
A
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
--
D
--
E
-
G
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
-----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
-
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------
38
Blastp_CBE
67.13
66%
-153
- C1 -
-
3PIZ
7.0
-
A:
[6-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
----------------
Y
G
S
--
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
---
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
-------
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
--------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
67
Blastp_CBE
67.10
66%
-156
- C1 -
-
6NFI
7.1
-
A:
[2-260]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
--
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
----
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
---
S
M
--
S
---
E
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
---
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
-------------------
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
200
Blastp_CBE
67.05
35%
10
- C1 -
-
1QCF
6.7
-
HCK_HUMAN
A:
[32-440]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
V
V
L
E
E
S
G
E
W
W
K
A
R
S
-
L
---
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
---------------------
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
T
-
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------
W
---------------
E
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
------
N
----
K
---
H
T
-
K
-
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
E
---
A
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
--
D
--
E
-
G
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
Y
T
--
A
R
E
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
-
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------
163
Blastp_CBE
67.01
40%
-11
- C1 -
-
4K11
6.1
-
SRC_HUMAN
A:
[64-434]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
W
Y
F
G
K
I
T
R
R
E
S
E
-
R
L
L
L
N
-
A
-
E
-
N
P
R
G
T
F
L
V
R
E
S
-
E
T
-
T
K
G
A
Y
C
L
S
V
-
S
D
F
D
N
A
K
G
L
-
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
T
S
K
---
P
Q
T
-----
Q
G
L
---------------
A
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
T-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
Q
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
35
Blastp_CBE
67.00
66%
-155
- C1 -
-
3PJ3
10.8
-
A:
[6-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
----------------
Y
G
S
--
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
---
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
------------
D
---
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
-----------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
194
Blastp_CBE
66.97
35%
2
- C1 -
-
2C0T
10.2
-
HCK_HUMAN
B:
[32-440]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
V
V
L
E
E
S
G
E
W
W
K
A
R
S
-
L
---
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
---------------------
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
T
-
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------
W
---------------
E
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
------
N
----
K
---
H
T
-
K
-
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
E
---
A
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
--
D
--
E
-
G
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
-----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
-
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------
553
HHSearch
66.96
38%
-56
- C1 -
-
3CBL
8.6
-
A:
[7-375]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
-
E
L
L
-
V
------
H
S
G
D
F
L
V
R
E
S
-
Q
----
Q
E
Y
V
L
S
V
------------
P
R
H
F
I
I
-----
N
L
Y
R
-
L
----
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
P
L
-----
V
V
L
H
--------------
R
A
V
---------------
P
----------------
K
D
K
--
W
V
L
-------
N
H
E
D
L
--------
V
-
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
------
R
----
A
D--
N
T
-
L
-
V
A
V
K
S
C
R
E
T
L
P
PD
L
---
K
A
---
K
F
L
Q
-
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
Q
P
-
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
-
T
--
E
--
G
-
A
R
-
L
R
V
-
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
--
A
S
G
G
L
R
Q
-
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
-
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
---
548
HHSearch
66.91
36%
11
- C1 -
-
2FO0
9.9
-
ABL1_HUMAN
A:
[38-476]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
D
P
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
G
Y
N
H
N
G
E
W
C
E
A
Q
-
T
-
K
N
G
Q
---
G
W
V
P
S
N
--------------------
Y
I
T
P
-
V
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
-
Y
L
L
-
S
---
S
-
G
I
N
G
S
F
L
V
R
E
S
-
E
S
S
P
-
G
Q
R
S
I
S
L
R
Y
E
------
G
-
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
K
R
N
K
P
T
V
Y
G
-----
V
S
P
---------------
N
----------------
Y
D
K
--
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
R
Q
E
-
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
---
156
Blastp_CBE
66.87
39%
-16
- C1 -
-
1OPL
9.4
-
ABL1_HUMAN
B:
[140-515]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
-
Y
L
L
---
S
-
S
-
G
I
N
G
S
F
L
V
R
E
S
E
S
S
-
P
-
G
Q
R
S
I
S
L
------
R
Y
E
G
-
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
--------------------------------------------------
D
K
--
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C-
N
--
R
-
Q
E
-
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
107
Blastp_CBE
66.73
61%
-149
- C1 -
-
3QGY
6.8
-
ITK_HUMAN
A:
[28-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
K
E
G
S
M
--
S
---
E
D
---
D
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----
177
Blastp_CBE
66.69
35%
-1
- C1 -
-
3VS6
8.2
-
HCK_HUMAN
A:
[32-440]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
V
V
L
E
E
S
G
E
W
W
K
A
R
S
-
L
---
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
---------------------
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
T
-
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------
W
---------------
E
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
------
N
----
K
---
H
T
-
K
-
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
E
---
A
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
--
D
--
E
-
G
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
-
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------
185
Blastp_CBE
66.63
35%
-5
- C1 -
-
3VS2
8.4
-
HCK_HUMAN
A:
[32-440]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
V
V
L
E
E
S
G
E
W
W
K
A
R
S
-
L
---
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
---------------------
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
T
-
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
---
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------
W
---------------
E
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
------
N
----
K
---
H
T
-
K
-
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
E
---
A
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
--
D
--
E
-
G
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
-----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
-
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------
130
Blastp_CBE
66.49
59%
-155
- C1 -
-
1SM2
8.4
-
B:
[6-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
R
E
G
A
M
--
S
---
E
E
---
D
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
-----------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----
180
Blastp_CBE
66.46
35%
-2
- C1 -
-
3VS4
7.1
-
HCK_HUMAN
B:
[32-440]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
V
V
L
E
E
S
G
E
W
W
K
A
R
S
-
L
---
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
---------------------
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
T
-
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------
W
---------------
E
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
------
N
----
K
---
H
T
-
K
-
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
E
---
A
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
--
D
--
E
-
G
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
-
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------
182
Blastp_CBE
66.34
35%
-5
- C1 -
-
3VS3
7.4
-
HCK_HUMAN
B:
[32-440]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
V
V
L
E
E
S
G
E
W
W
K
A
R
S
-
L
---
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
---------------------
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
T
-
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
-----
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------
W
---------------
E
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
------
N
----
K
---
H
T
-
K
-
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
E
---
A
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
--
D
--
E
-
G
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
-------------
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
-
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------
155
Blastp_CBE
66.31
39%
-19
- C1 -
-
2FO0
9.9
-
ABL1_HUMAN
A:
[98-473]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
-
Y
L
L
---
S
-
S
-
G
I
N
G
S
F
L
V
R
E
S
E
S
S
-
P
-
G
Q
R
S
I
S
L
------
R
Y
E
G
-
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
K
R
N
K
P
T
V
Y
G
-----
V
S
P
---------------
N
----------------
Y
D
K
--
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C-
N
--
R
-
Q
E
-
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
544
HHSearch
66.27
34%
24
- C1 -
-
5H0B
9.9
-
HCK_HUMAN
A:
[8-445]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
E
S
G
-
E
W
W
K
A
R
S
-
L
A
T
R
K
E
---
G
Y
I
P
S
N
--------------------
Y
V
A
R
-
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
-
R
Q
L
-
L
-
A
P
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
T
T
K
-
G
S
Y
S
L
S
V
R
D
Y
D
P
-
R
Q
G
D
-
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
---
P
-
Q
-----
K
P
W
---------------
E
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
------
N
----
K
---
H
T
-
K
-
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
E
---
A
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
--
D
--
E
G
S
K
-
Q
P
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
Y
T
--
A
R
E
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
-
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
---
129
Blastp_CBE
66.24
59%
-148
- C1 -
-
1SNU
7.5
-
ITK_HUMAN
A:
[6-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
R
E
G
A
M
--
S
---
E
E
---
D
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----
188
Blastp_CBE
66.22
35%
0
- C1 -
-
3VS0
8.4
-
HCK_HUMAN
B:
[32-440]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
V
V
L
E
E
S
G
E
W
W
K
A
R
S
-
L
---
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
---------------------
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
T
-
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------
W
---------------
E
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
------
N
----
K
---
H
T
-
K
-
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
E
---
A
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
--
D
--
E
-
G
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
-----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
-
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------
140
Blastp_CBE
66.22
59%
-150
- C1 -
-
4PP9
5.1
-
B:
[8-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
R
E
G
A
M
--
S
---
E
E
---
D
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
---------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----
196
Blastp_CBE
66.20
35%
-2
- C1 -
-
2C0O
10.4
-
HCK_HUMAN
B:
[32-440]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
V
V
L
E
E
S
G
E
W
W
K
A
R
S
-
L
---
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
---------------------
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
T
-
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------
W
---------------
E
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
------
N
----
K
---
H
T
-
K
-
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
E
---
A
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
--
D
--
E
-
G
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
-----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
-
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------
546
HHSearch
66.16
36%
5
- C1 -
-
5MO4
12.1
-
ABL1_HUMAN
A:
[44-479]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
G
Y
N
H
N
G
E
W
C
E
A
Q
-
T
-
K
N
G
Q
---
G
W
V
P
S
N
--------------------
Y
I
T
P
-
V
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
-
Y
L
L
-
S
-
S
---
G
I
N
G
S
F
L
V
R
E
S
-
E
S
S
P
-
G
Q
R
S
I
S
L
R
Y
E
------
G
-
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
K
R
N
K
P
T
V
Y
G
-----
V
S
P
---------------
N
----------------
Y
D
K
--
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
----
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
R
Q
E
-
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
----------------------
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
---
164
Blastp_CBE
66.13
40%
-15
- C1 -
-
1KSW
5.7
-
SRC_HUMAN
A:
[66-436]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
W
Y
F
G
K
I
T
R
R
E
S
E
-
R
L
L
L
N
-
A
-
E
-
N
P
R
G
T
F
L
V
R
E
S
-
E
T
-
T
K
G
A
Y
C
L
S
V
-
S
D
F
D
N
A
K
G
L
-
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
T
S
K
---
P
Q
T
-----
Q
G
L
---------------
A
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
T-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
Q
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
110
Blastp_CBE
66.07
59%
-152
- C1 -
-
4RFM
6.6
-
A:
[8-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
R
E
G
A
M
--
S
---
E
E
---
D
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
------
145
Blastp_CBE
66.05
59%
-147
- C1 -
-
4L7S
6.8
-
ITK_HUMAN
A:
[8-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
R
E
G
A
M
--
S
---
E
E
---
D
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
--------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----
540
HHSearch
66.03
36%
24
- C1 -
-
2H8H
8.1
-
SRC_HUMAN
A:
[87-524]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
F
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
N
T
E
G
D
W
W
L
A
H
S
-
L
S
T
G
Q
T
---
G
Y
I
P
S
N
--------------------
Y
V
A
P
-
S
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
-
R
L
L
-
L
-
N
A
E
-
N
P
R
G
T
F
L
V
R
E
S
-
E
T
T
K
-
G
A
Y
C
L
S
V
S
D
F
D
N
-
A
K
G
L
-
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
T
S
---
K
P
Q
T
-----
Q
G
L
---------------
A
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
--
T
G
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
Q
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
---
162
Blastp_CBE
66.02
40%
-12
- C1 -
-
6F3F
5.4
-
SRC_MOUSE
A:
[69-439]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
W
Y
F
G
K
I
T
R
R
E
S
E
-
R
L
L
L
N
-
A
-
E
-
N
P
R
G
T
F
L
V
R
E
S
-
E
T
-
T
K
G
A
Y
C
L
S
V
-
S
D
F
D
N
A
K
G
L
-
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
T
S
K
---
P
Q
T
-----
Q
G
L
---------------
A
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
-
G
--
E
T-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
Q
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
192
Blastp_CBE
66.00
35%
2
- C1 -
-
3VRY
7.3
-
HCK_HUMAN
B:
[32-440]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
V
V
L
E
E
S
G
E
W
W
K
A
R
S
-
L
---
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
---------------------
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
T
-
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------
W
---------------
E
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
------
N
----
K
---
H
T
-
K
-
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
E
---
A
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
--
D
--
E
-
G
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
-
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------
199
Blastp_CBE
65.93
35%
1
- C1 -
-
2C0I
11.4
-
HCK_HUMAN
A:
[32-440]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
V
V
L
E
E
S
G
E
W
W
K
A
R
S
-
L
---
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
---------------------
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
T
-
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------
W
---------------
E
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
------
N
----
K
---
H
T
-
K
-
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
E
---
A
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
--
D
--
E
-
G
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
-----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
-
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------
176
Blastp_CBE
65.86
35%
-1
- C1 -
-
3VS6
8.2
-
HCK_HUMAN
B:
[32-440]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
V
V
L
E
E
S
G
E
W
W
K
A
R
S
-
L
---
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
---------------------
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
T
-
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------
W
---------------
E
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
------
N
----
K
---
H
T
-
K
-
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
E
---
A
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
--
D
--
E
-
G
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
-
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------
186
Blastp_CBE
65.84
35%
-2
- C1 -
-
3VS1
8.8
-
HCK_HUMAN
B:
[32-440]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
V
V
L
E
E
S
G
E
W
W
K
A
R
S
-
L
---
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
---------------------
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
T
-
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------
W
---------------
E
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
------
N
----
K
---
H
T
-
K
-
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
E
---
A
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
--
D
--
E
-
G
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
-----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
-
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------
542
HHSearch
65.82
36%
29
- C1 -
-
1Y57
7.3
-
SRC_HUMAN
A:
[3-441]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
F
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
N
T
E
G
D
W
W
L
A
H
S
L
S
-
T
G
Q
T
---
G
Y
I
P
S
N
--------------------
Y
V
A
P
-
S
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
-
R
L
L
-
L
-
N
A
E
-
N
P
R
G
T
F
L
V
R
E
S
-
E
T
T
K
-
G
A
Y
C
L
S
V
S
D
F
D
N
-
A
K
G
L
-
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
T
S
---
K
P
Q
T
-----
Q
G
L
---------------
A
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
--
T
G
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
Q
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
---
195
Blastp_CBE
65.78
35%
-6
- C1 -
-
2C0T
10.8
-
HCK_HUMAN
A:
[32-440]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
V
V
L
E
E
S
G
E
W
W
K
A
R
S
-
L
---
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
---------------------
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
T
-
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
------
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------
W
---------------
E
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
------
N
----
K
---
H
T
-
K
-
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
E
---
A
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
--
D
--
E
-
G
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
-----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
-
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------
63
Blastp_CBE
65.76
66%
-168
- C1 -
-
5XYZ
7.0
-
BTK_HUMAN
A:
[3-260]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
-------
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
---
M
--
S
---
E
D
------
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--------
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
------------------
F
P
V
R
W
S
P
P
E
V
L
M
---
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
147
Blastp_CBE
65.73
59%
-149
- C1 -
-
4KIO
4.6
-
ITK_HUMAN
C:
[8-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
R
E
G
A
M
--
S
---
E
E
---
D
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----
131
Blastp_CBE
65.69
59%
-149
- C1 -
-
1SM2
7.5
-
ITK_HUMAN
A:
[6-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
R
E
G
A
M
--
S
---
E
E
---
D
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----
144
Blastp_CBE
65.66
59%
-143
- C1 -
-
4L7S
5.9
-
B:
[8-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
R
E
G
A
M
--
S
---
E
E
---
D
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
--------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----
128
Blastp_CBE
65.58
59%
-153
- C1 -
-
1SNU
7.4
-
B:
[6-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
R
E
G
A
M
--
S
---
E
E
---
D
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
-----------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----
198
Blastp_CBE
65.56
35%
4
- C1 -
-
2C0I
11.1
-
HCK_HUMAN
B:
[32-440]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
V
V
L
E
E
S
G
E
W
W
K
A
R
S
-
L
---
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
---------------------
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
T
-
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------
W
---------------
E
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
------
N
----
K
---
H
T
-
K
-
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
E
---
A
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
--
D
--
E
-
G
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
-----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
-
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------
158
Blastp_CBE
65.54
39%
-25
- C1 -
-
5MO4
12.1
-
ABL1_HUMAN
A:
[101-476]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
-
Y
L
L
---
S
-
S
-
G
I
N
G
S
F
L
V
R
E
S
E
S
S
-
P
-
G
Q
R
S
I
S
L
------
R
Y
E
G
-
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
K
R
N
K
P
T
V
Y
G
-----
V
S
P
---------------
N
----------------
Y
D
K
--
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
----
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C-
N
--
R
-
Q
E
-
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
----------------------
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
429
Blastp_CBE
65.51
37%
-39
- C1 -
-
3CBL
8.6
-
A:
[5-376]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
Q
K
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
-
E
L
L
-
V
-
H
-
S
-
G
D
---
F
L
V
R
E
S
-
Q
----
Q
E
Y
V
L
S
V
------------
P
R
H
F
I
I
------
N
L
Y
R
L
----
F
P
S
I
P
L
L
I
D
H
--------
L
L
S
T
Q
Q
P
L
-----
V
V
L
H
R
------
A
V
---------------
P
----------------
K
D
K
--
W
V
L
-------
N
H
E
D
L
--------
V
-
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
------
R
----
A
---
D
N
-
T
L
V
A
V
K
S
C
R
E
-
T
L
--
P
---
P
D
LKA
K
F
L
Q
-
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
Q
P
-
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
-
T
--
E
--
G
-
A
R
-
L
R
V
-
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
--
A
S
G
-
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
-
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
H
--
184
Blastp_CBE
65.42
35%
1
- C1 -
-
3VS2
6.4
-
HCK_HUMAN
B:
[32-440]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
V
V
L
E
E
S
G
E
W
W
K
A
R
S
-
L
---
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
---------------------
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
T
-
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------
W
---------------
E
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
------
N
----
K
---
H
T
-
K
-
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
E
---
A
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
--
D
--
E
-
G
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
-----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
-
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------
106
Blastp_CBE
65.41
61%
-137
- C1 -
-
3QGY
5.3
-
B:
[28-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
K
E
G
S
M
--
S
---
E
D
---
D
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
--------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
-----
174
Blastp_CBE
65.33
35%
-2
- C1 -
-
3VS7
6.9
-
HCK_HUMAN
B:
[32-440]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
V
V
L
E
E
S
G
E
W
W
K
A
R
S
-
L
---
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
---------------------
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
T
-
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
-----
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------
W
---------------
E
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
------
N
----
K
---
H
T
-
K
-
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
E
---
A
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
--
D
--
E
-
G
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
-------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
-
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------
181
Blastp_CBE
65.20
35%
-8
- C1 -
-
3VS4
6.3
-
HCK_HUMAN
A:
[32-440]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
V
V
L
E
E
S
G
E
W
W
K
A
R
S
-
L
---
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
---------------------
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
T
-
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
------
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------
W
---------------
E
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
------
N
----
K
---
H
T
-
K
-
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
E
---
A
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
--
D
--
E
-
G
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
---------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
-
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------
175
Blastp_CBE
65.20
35%
3
- C1 -
-
3VS7
7.0
-
HCK_HUMAN
A:
[32-440]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
V
V
L
E
E
S
G
E
W
W
K
A
R
S
-
L
---
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
---------------------
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
T
-
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------
W
---------------
E
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
------
N
----
K
---
H
T
-
K
-
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
E
---
A
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
--
D
--
E
-
G
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
-
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------
179
Blastp_CBE
65.18
35%
2
- C1 -
-
3VS5
8.5
-
HCK_HUMAN
A:
[32-440]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
V
V
L
E
E
S
G
E
W
W
K
A
R
S
-
L
---
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
---------------------
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
T
-
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------
W
---------------
E
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
------
N
----
K
---
H
T
-
K
-
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
E
---
A
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
--
D
--
E
-
G
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
-----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
-
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------
118
Blastp_CBE
65.12
59%
-158
- C1 -
-
3V8W
3.2
-
B:
[8-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
--------
T
-
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
R
---
M
--
S
---
E
E
---
D
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----
190
Blastp_CBE
65.08
35%
2
- C1 -
-
3VRZ
8.5
-
HCK_HUMAN
B:
[32-440]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
V
V
L
E
E
S
G
E
W
W
K
A
R
S
-
L
---
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
---------------------
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
T
-
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------
W
---------------
E
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
------
N
----
K
---
H
T
-
K
-
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
E
---
A
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
--
D
--
E
-
G
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
-
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------
126
Blastp_CBE
65.02
59%
-162
- C1 -
-
3V5J
6.8
-
B:
[8-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
--------
T
-
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
----
M
--
S
---
E
E
---
D
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
-----------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----
178
Blastp_CBE
64.99
35%
-1
- C1 -
-
3VS5
8.6
-
HCK_HUMAN
B:
[32-440]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
V
V
L
E
E
S
G
E
W
W
K
A
R
S
-
L
---
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
---------------------
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
T
-
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
------
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------
W
---------------
E
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
------
N
----
K
---
H
T
-
K
-
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
E
---
A
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
--
D
--
E
-
G
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
-----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
-
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------
183
Blastp_CBE
64.98
35%
-3
- C1 -
-
3VS3
5.5
-
HCK_HUMAN
A:
[32-440]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
V
V
L
E
E
S
G
E
W
W
K
A
R
S
-
L
---
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
---------------------
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
T
-
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------
W
---------------
E
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
------
N
----
K
---
H
T
-
K
-
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
E
---
A
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
--
D
--
E
-
G
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
-
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------
202
Blastp_CBE
64.97
35%
3
- C1 -
-
2HCK
6.3
-
HCK_HUMAN
A:
[26-424]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
V
V
L
E
E
S
G
E
W
W
K
A
R
S
-
L
---
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
---------------------
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
T
-
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------
W
---------------
E
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
------
N
----
K
---
H
T
-
K
-
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
E
---
A
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
--
D
--
E
-
G
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
------------
V
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
-
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------
173
Blastp_CBE
64.94
35%
-2
- C1 -
-
4LUD
4.8
-
HCK_HUMAN
A:
[32-440]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
V
V
L
E
E
S
G
E
W
W
K
A
R
S
-
L
---
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
T
-
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
--
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------
W
---------------
E
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
------
N
----
K
---
H
T
-
K
-
V
A
V
K
T
M
K
P
-----
S
---
V
E
---
A
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
--
D
--
E
-
G
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
-----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
-
P
G
M
S
N
P
E
----
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------
120
Blastp_CBE
64.92
59%
-151
- C1 -
-
3V8T
6.3
-
B:
[8-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
--------
T
-
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
---
A
M
--
S
---
E
E
---
D
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
--------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----
193
Blastp_CBE
64.89
35%
-3
- C1 -
-
3VRY
5.7
-
HCK_HUMAN
A:
[32-440]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
V
V
L
E
E
S
G
E
W
W
K
A
R
S
-
L
---
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
---------------------
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
T
-
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
------
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------
W
---------------
E
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
------
N
----
K
---
H
T
-
K
-
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
E
---
A
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
--
D
--
E
-
G
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
-
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------
189
Blastp_CBE
64.87
35%
-6
- C1 -
-
3VS0
7.8
-
HCK_HUMAN
A:
[32-440]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
V
V
L
E
E
S
G
E
W
W
K
A
R
S
-
L
---
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
---------------------
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
T
-
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
-----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------
W
---------------
E
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
------
N
----
K
---
H
T
-
K
-
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
E
---
A
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
--
D
--
E
-
G
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
-----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
-
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------
123
Blastp_CBE
64.85
59%
-151
- C1 -
-
3V5L
7.3
-
ITK_HUMAN
C:
[8-262]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
--------
T
-
F
V
Q
E
I
G
S
---
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
R
E
G
A
M
--
S
---
E
E
---
D
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
-----
197
Blastp_CBE
64.80
35%
1
- C1 -
-
2C0O
10.2
-
HCK_HUMAN
A:
[32-440]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
V
V
L
E
E
S
G
E
W
W
K
A
R
S
-
L
---
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
---------------------
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
T
-
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------
W
---------------
E
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
------
N
----
K
---
H
T
-
K
-
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
E
---
A
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
--
D
--
E
-
G
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
-----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
-
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------
203
Blastp_CBE
64.78
35%
8
- C1 -
-
1AD5
4.4
-
HCK_HUMAN
B:
[26-424]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
V
V
L
E
E
S
G
E
W
W
K
A
R
S
-
L
---
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
---------------------
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
T
-
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------
W
---------------
E
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
------
N
----
K
---
H
T
-
K
-
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
E
---
A
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
--
D
--
E
-
G
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
------------
V
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
-
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------
119
Blastp_CBE
64.75
59%
-155
- C1 -
-
3V8W
3.5
-
ITK_HUMAN
A:
[8-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
--------
T
-
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
R
-
G
A
M
--
S
---
E
E
---
D
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
-
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----
141
Blastp_CBE
64.66
59%
-148
- C1 -
-
4PP9
4.9
-
ITK_HUMAN
A:
[8-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
R
E
G
A
M
--
S
---
E
E
---
D
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----
149
Blastp_CBE
64.63
59%
-155
- C1 -
-
4KIO
6.0
-
ITK_HUMAN
A:
[8-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
--------
T
-
F
V
Q
E
I
G
S
---
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
-----------
E
E
---
D
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
--------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----
127
Blastp_CBE
64.49
59%
-154
- C1 -
-
3V5J
6.7
-
ITK_HUMAN
A:
[8-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
-
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
R
E
G
----
S
---
E
E
---
D
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
-
R
S
N
S
E
V
V
E
D
I
S
T
G
-
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----
146
Blastp_CBE
64.46
59%
-151
- C1 -
-
4KIO
4.5
-
D:
[8-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
-------
S
---
E
E
---
D
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
---------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----
62
Blastp_CBE
64.44
66%
-157
- C1 -
-
5XYZ
7.1
-
B:
[3-260]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
-------
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
---
M
--
S
---
E
D
---
E
-
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
------------------
F
P
V
R
W
S
P
P
E
V
L
M
----
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
108
Blastp_CBE
64.34
61%
-148
- C1 -
-
3QGW
5.0
-
B:
[28-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
K
E
G
S
M
--
S
---
E
D
---
D
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
-----------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
-----
41
Blastp_CBE
64.34
64%
-148
- C1 -
-
3K54
7.4
-
A:
[16-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
--
W
E
I
-------
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
------
R
----
G
---
Q
Y
-
D
-
V
A
I
K
M
I
K
---------------
E
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--
M
--
R
-
H
R
-
F
Q
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
---------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
-
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
112
Blastp_CBE
64.32
59%
-147
- C1 -
-
4MF1
5.0
-
B:
[8-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
--------
T
-
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
---
A
M
--
S
---
E
E
---
D
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
------
148
Blastp_CBE
64.21
59%
-159
- C1 -
-
4KIO
4.9
-
ITK_HUMAN
B:
[8-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
--------
T
-
F
V
Q
E
I
G
S
---
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
------------
E
---
D
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
--------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----
113
Blastp_CBE
64.13
59%
-150
- C1 -
-
4MF1
4.5
-
ITK_HUMAN
A:
[8-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
--------
T
-
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
---
A
M
--
S
---
E
E
---
D
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
---------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
------
122
Blastp_CBE
64.08
59%
-153
- C1 -
-
3V5L
7.4
-
D:
[8-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
-
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
R
--
A
M
--
S
---
E
E
---
D
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
--------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----
116
Blastp_CBE
64.01
59%
-156
- C1 -
-
3MIY
6.8
-
B:
[8-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
--------
T
-
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
-------
S
---
E
E
---
D
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
------
171
Blastp_CBE
63.94
35%
-0
- C1 -
-
4LUE
9.7
-
HCK_HUMAN
A:
[32-440]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
V
V
L
E
E
S
G
E
W
W
K
A
R
S
-
L
---
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
---------------------
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
T
-
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------
W
---------------
E
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
------
N
----
K
---
H
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--------------
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
--
D
--
E
-
G
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
-----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
-
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------
170
Blastp_CBE
63.90
35%
-5
- C1 -
-
4LUE
9.5
-
HCK_HUMAN
B:
[32-440]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
V
V
L
E
E
S
G
E
W
W
K
A
R
S
-
L
---
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
---------------------
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
T
-
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------
W
---------------
E
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
------
N
----
K
---
H
T
-
K
-
V
A
V
K
T
M
K
P
----------------
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
--
D
--
E
-
G
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
-----------------
P
I
K
W
T
A
P
E
A
I
N
---
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
-
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------
125
Blastp_CBE
63.77
59%
-148
- C1 -
-
3V5L
7.6
-
ITK_HUMAN
A:
[8-262]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
--------
T
-
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
----
M
--
S
---
E
E
---
D
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
--------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
-----
204
Blastp_CBE
63.74
35%
8
- C1 -
-
1AD5
4.7
-
HCK_HUMAN
A:
[26-424]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
V
V
L
E
E
S
G
E
W
W
K
A
R
S
-
L
---
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
---------------------
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
T
-
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------
W
---------------
E
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
------
N
----
K
---
H
T
-
K
-
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
E
---
A
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
--
D
--
E
-
G
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
------------
V
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
-
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------
124
Blastp_CBE
63.71
59%
-150
- C1 -
-
3V5L
7.4
-
ITK_HUMAN
B:
[8-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
--------
T
-
F
V
Q
E
I
G
S
----
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
R
------
S
---
E
E
---
D
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
--------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----
111
Blastp_CBE
63.63
59%
-140
- C1 -
-
4PQN
5.7
-
A:
[8-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
--------
T
-
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
R
E
G
A
M
--
S
---
E
E
---
D
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
---------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
------
121
Blastp_CBE
63.51
59%
-151
- C1 -
-
3V8T
6.2
-
ITK_HUMAN
A:
[8-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
--------
T
-
F
V
Q
E
I
G
S
---
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
R
E
G
A
M
--
S
---
E
E
---
D
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
---------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-------
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----
187
Blastp_CBE
63.31
35%
2
- C1 -
-
3VS1
6.8
-
HCK_HUMAN
A:
[32-440]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
V
V
L
E
E
S
G
E
W
W
K
A
R
S
-
L
---
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
---------------------
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
T
-
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
---------
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------
W
---------------
E
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
------
N
----
K
---
H
T
-
K
-
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
E
---
A
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
--
D
--
E
-
G
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
-----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
-
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------
117
Blastp_CBE
63.11
59%
-154
- C1 -
-
3MIY
6.7
-
ITK_HUMAN
A:
[8-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
--------
T
-
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
-------
S
---
E
E
---
D
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
-----------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
------
201
Blastp_CBE
62.91
35%
5
- C1 -
-
2HCK
5.8
-
HCK_HUMAN
B:
[26-424]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
V
V
L
E
E
S
G
E
W
W
K
A
R
S
-
L
---
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
---------------------
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
T
-
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------
W
---------------
E
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
------
N
----
K
---
H
T
-
K
-
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
E
---
A
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
--
D
--
E
-
G
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
------------
V
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
-
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------
139
Blastp_CBE
62.63
59%
-158
- C1 -
-
4PPA
5.5
-
ITK_HUMAN
A:
[8-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
------------
E
---
D
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----
115
Blastp_CBE
62.37
59%
-154
- C1 -
-
3MJ1
6.4
-
A:
[8-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
--------
T
-
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
-------------------
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
-----------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
-
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
------
133
Blastp_CBE
62.28
59%
-149
- C1 -
-
4QD6
5.0
-
ITK_HUMAN
A:
[8-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
-------
S
---
E
E
---
D
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
--------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----
523
Fugue
62.11
38%
-43
- C1 -
-
3CD3
8.5
-
A:
[1-376]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
I
P
E
V
Q
K
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
-
E
L
L
-
V
-
H
-
S
-
G
---
D
F
L
V
R
E
S
-
Q
E
-----
Y
V
L
S
V
------
P
R
H
F
-
I
I
N
L
Y
R
L
---------------
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
P
L
S
G
V
V
L
H
R
A
V
P
K
D
K
--------------------------------------------------
W
V
L
-------
N
H
E
D
L
--------
V
-
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
------
R
----
A
---
D
N
T
L
-
V
A
V
K
S
C
R
P
D
L
K
--
A
---
K
-----
F
L
Q
-
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
Q
P
-
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
-
T
--
E
--
G
-
A
R
-
L
R
V
-
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
A
A
--
S
G
G
-
L
R
Q
-
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
-
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
H
--
554
HHSearch
61.91
40%
-24
- C1 -
-
4XEY
7.8
-
ABL1_HUMAN
B:
[7-384]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
-
Y
L
L
-
S
---
S
-
G
I
N
G
S
F
L
V
R
E
S
-
E
S
S
P
-
G
Q
R
S
I
S
L
R
Y
E
------
G
-
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
---
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
K
------------------------------------------------
Y
D
K
--
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
------
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
---
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
R
Q
E
-
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
---
132
Blastp_CBE
61.87
59%
-151
- C1 -
-
4QD6
5.3
-
B:
[8-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
-----------
E
E
---
D
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
--------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----
152
Blastp_CBE
61.68
40%
-22
- C1 -
-
4XEY
7.8
-
ABL1_HUMAN
B:
[7-381]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
-
Y
L
L
---
S
-
S
-
G
I
N
G
S
F
L
V
R
E
S
E
S
S
-
P
-
G
Q
R
S
I
S
L
------
R
Y
E
G
-
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
---
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
K
------------------------------------------------
Y
D
K
--
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
------
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
---
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C-
N
--
R
-
Q
E
-
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
543
HHSearch
61.64
34%
23
- C1 -
-
2HCK
5.8
-
HCK_HUMAN
B:
[2-429]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
E
S
-
G
E
W
W
K
A
R
S
-
L
A
T
R
K
E
---
G
Y
I
P
S
N
--------------------
Y
V
A
R
-
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
-
R
Q
L
-
L
-
A
-
P
G
N
M
L
G
S
F
M
I
R
D
S
-
E
T
T
K
-
G
S
Y
S
L
S
V
R
D
Y
D
P
-
R
Q
G
D
-
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
---------
K
P
W
---------------
E
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
------
N
----
K
---
H
T
-
K
-
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
E
---
A
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
E
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
--
D
--
E
G
S
K
-
Q
P
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
G
A
K
--------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
-
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
---
143
Blastp_CBE
61.60
59%
-156
- C1 -
-
4MF0
4.3
-
ITK_HUMAN
A:
[8-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
--------
T
-
F
V
Q
E
I
G
S
---
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
----
M
--
S
---
E
E
---
D
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
--------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----
558
HHSearch
61.57
33%
-7
- C1 -
-
4FL3
6.2
-
KSYK_HUMAN
A:
[161-633]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
H
E
K
M
P
W
F
H
G
K
I
S
R
E
E
S
E
-
Q
I
V
-
L
I
G
-
S
-
K
T
N
G
K
F
L
I
R
A
R
-
D
N
-
N
-
G
S
Y
A
L
C
L
L
H
E
------
G
-
K
V
L
H
Y
R
I
D
K
D
K
T
G
K
L
S
I
P
E
G
K
K
F
D
T
L
W
Q
L
V
E
H
Y
S
Y
K
A
D
G
L
L
R
V
L
T
V
P
C
Q
K
--------------------------------REALPMDTEVFESPF-
A
D
P
--
E
E
I
-------
R
P
K
E
V
YLDRKLLT
L
-
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
------
Q
----
M
KKV
V
K
-
T
-
V
A
V
K
I
L
K
N
E
A
N
--
D
PAL
K
D
---
E
L
L
A
-
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
-
E
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
-
Q
--
N
--
R
--
H
-
V
K
D
-
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
---------------
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
-
R
G
M
K
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
V
--
478
Blastp_CBE
61.33
36%
-38
- C1 -
-
3CD3
8.5
-
A:
[5-376]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
Q
K
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
-
E
L
L
-
V
-
H
-
S
-
G
D
---
F
L
V
R
E
S
------
Q
E
Y
V
L
S
V
------------
P
R
H
F
I
I
------
N
L
Y
R
L
----
F
P
S
I
P
L
L
I
D
H
--------
L
L
S
T
Q
Q
P
L
---
S
G
V
V
L
H
R
------
A
V
---------------
P
----------------
K
D
K
--
W
V
L
-------
N
H
E
D
L
--------
V
-
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
------
R
----
A
---
D
N
-
T
L
V
A
V
K
S
C
R
----------
P
D
LKA
K
F
L
Q
-
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
Q
P
-
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
-
T
--
E
--
G
-
A
R
-
L
R
V
-
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
A
A
--
S
G
G
-
L
R
Q
-
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
-
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
H
R
-
172
Blastp_CBE
61.33
35%
-15
- C1 -
-
4LUD
6.2
-
HCK_HUMAN
B:
[32-440]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
V
V
L
E
E
S
G
E
W
W
K
A
R
S
-
L
---
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
---------------------
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
M
L
G
S
F
M
I
R
D
S
-
E
T
----
S
Y
S
L
S
V
--
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
-----------------
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------
W
---------------
E
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
------
N
----
K
---
H
T
-
K
-
V
A
V
K
T
M
K
P
G
----
S
---
V
E
---
A
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
--
D
--
E
-
G
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
-----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
-
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------
138
Blastp_CBE
61.22
59%
-155
- C1 -
-
4PPA
5.9
-
B:
[8-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
------------
E
---
D
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----
555
HHSearch
60.79
30%
-7
- C1 -
-
4K2R
5.9
-
ZAP70_HUMAN
A:
[156-599]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
H
E
R
M
P
W
Y
H
S
S
L
T
R
E
E
A
E
-
R
K
L
-
Y
-
S
G
A
-
Q
T
D
G
K
F
L
L
R
P
R
-
K
E
-
Q
-
G
T
Y
A
L
S
L
I
Y
G
------
K
-
T
V
Y
H
Y
L
I
S
Q
D
K
A
G
K
Y
C
I
P
E
G
T
K
F
D
T
L
W
Q
L
V
E
Y
L
K
L
K
A
D
G
L
I
Y
C
L
K
E
A
C
P
N
S
-------DKPRP
M
P
M
---------------
D
TSVYESPYSDPEELKD
K
K
L
--
F
L
K
-------
R
D
N
L
L
--------
I
-
A
D
I
E
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
------
R
----
M
RKK
Q
I
-
D
-
V
A
I
K
V
L
K
Q
G
T
E
KA
D
---
T
E
---
E
M
M
R
-
E
A
Q
I
M
H
Q
L
D
N
P
Y
I
V
R
L
I
G
V
C
Q
A
-
E
A
-
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
-
G
--
K
--
R
-
E
E
-
I
P
V
-
S
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
N
L
A
A
R
N
V
L
L
V
N
R
H
Y
A
K
I
S
D
F
G
L
S
-------------------
W
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
Q
K
P
Y
-
K
K
M
K
G
P
E
V
M
A
F
I
E
Q
G
K
R
M
E
C
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
Y
S
---
556
HHSearch
60.58
34%
9
- C1 -
-
4FL2
6.4
-
KSYK_HUMAN
A:
[162-633]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
H
E
K
M
P
W
F
H
G
K
I
S
R
E
E
S
E
-
Q
I
V
L
I
-
G
-
S
-
K
T
N
G
K
F
L
I
R
A
R
-
D
N
-
N
-
G
S
Y
A
L
C
L
L
H
E
------
G
-
K
V
L
H
Y
R
I
D
K
D
K
T
G
K
L
S
I
P
E
G
K
K
F
D
T
L
W
Q
L
V
E
H
Y
S
Y
K
A
D
G
L
L
R
V
L
T
V
P
C
Q
K
I
G
T
-----------------------------QREALPMDTEVYESPY
A
D
P
--
E
E
I
RPKEVYL
D
R
K
L
L
--------
T
L
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
------
Q
----
M
KKV
V
K
-
T
-
V
A
V
K
I
L
K
N
E
A
N
--
D
PAL
K
D
---
E
L
L
A
-
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
E
-
A
E
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
-
Q
--
N
--
R
--
H
-
V
K
D
-
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
YK
A
Q
T
-
H
G
K
-
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
-
R
G
M
K
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
---
135
Blastp_CBE
60.54
59%
-162
- C1 -
-
4PPC
5.7
-
ITK_HUMAN
A:
[8-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
--------
T
-
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
------------------
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
-----------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----
142
Blastp_CBE
60.53
59%
-155
- C1 -
-
4MF0
4.8
-
B:
[8-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
--------
T
-
F
V
Q
E
I
G
S
---
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
----
M
--
S
---
E
E
---
D
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
-----------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----
136
Blastp_CBE
60.41
59%
-148
- C1 -
-
4PPB
5.9
-
B:
[8-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
------------
E
---
D
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----
557
HHSearch
60.33
30%
-11
- C1 -
-
2OZO
6.1
-
ZAP70_HUMAN
A:
[156-599]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
H
E
R
M
P
W
Y
H
S
S
L
T
R
E
E
A
E
-
R
K
L
-
Y
-
S
G
A
-
Q
T
D
G
K
F
L
L
R
P
R
-
K
E
-
Q
-
G
T
Y
A
L
S
L
I
Y
G
------
K
-
T
V
Y
H
Y
L
I
S
Q
D
K
A
G
K
Y
C
I
P
E
G
T
K
F
D
T
L
W
Q
L
V
E
Y
L
K
L
K
A
D
G
L
I
Y
C
L
K
E
A
C
P
N
---------------
M
DTSVFESPFSDPEEL
K
D---------------
K
K
L
--
F
L
K
-------
R
D
N
L
L
--------
I
-
A
D
I
E
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
------
R
----
M
RKK
Q
I
-
D
-
V
A
I
K
V
L
K
Q
G
T
E
KA
D
---
T
E
---
E
M
M
R
-
E
A
Q
I
M
H
Q
L
D
N
P
Y
I
V
R
L
I
G
V
C
Q
A
-
E
A
-
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
-
G
--
K
--
R
-
E
E
-
I
P
V
-
S
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
N
L
A
A
R
N
V
L
L
V
N
R
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
G
----------------
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
Q
K
P
Y
-
K
K
M
K
G
P
E
V
M
A
F
I
E
Q
G
K
R
M
E
C
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
Y
S
---
137
Blastp_CBE
60.09
59%
-153
- C1 -
-
4PPB
5.6
-
ITK_HUMAN
A:
[8-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
------------
E
---
D
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----
134
Blastp_CBE
59.35
59%
-157
- C1 -
-
4PPC
5.5
-
B:
[8-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
--------
T
-
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
------
L
----
N
---
K
D
-
K
-
V
A
I
K
T
I
------------------
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
--
Q
--
R
-
G
L
-
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
-----------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----
212
Blastp_CBE
58.77
46%
-64
- C1 -
-
2OF4
6.4
-
LCK_HUMAN
A:
[8-265]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
-------
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
------
N
----
G
---
H
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
M
--
S
---
P
D
---
A
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P-
S
--
G
-
I
K
-
L
T
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
E
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
-
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------
213
Blastp_CBE
58.72
46%
-62
- C1 -
-
2OF2
7.1
-
LCK_HUMAN
A:
[8-265]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
-------
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
------
N
----
G
---
H
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
M
--
S
---
P
D
---
A
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P-
S
--
G
-
I
K
-
L
T
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
E
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
-
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------
207
Blastp_CBE
58.42
46%
-67
- C1 -
-
3B2W
10.8
-
LCK_HUMAN
A:
[13-270]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
-------
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
------
N
----
G
---
H
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
M
--
S
---
P
D
---
A
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P-
S
--
G
-
I
K
-
L
T
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
---
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
-
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------
236
Blastp_CBE
58.23
45%
-68
- C1 -
-
2OFU
8.2
-
LCK_HUMAN
A:
[10-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
-------
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
------
N
----
G
---
H
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
M
--
S
---
P
D
---
A
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P-
S
--
G
-
I
K
-
L
T
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
E
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
-
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------
392
Blastp_CBE
58.18
45%
-64
- C1 -
-
3U4W
10.6
-
A:
[2-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
Q
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
232
Blastp_CBE
58.13
45%
-63
- C1 -
-
3BYM
8.6
-
LCK_HUMAN
A:
[9-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
-------
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
------
N
----
G
---
H
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
M
--
S
---
P
D
---
A
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P-
S
--
G
-
I
K
-
L
T
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
E
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
-
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------
235
Blastp_CBE
57.95
45%
-73
- C1 -
-
6PDJ
8.0
-
?
A:
[17-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
-------
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
------
N
----
G
---
H
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
M
--
S
---
P
D
---
A
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P-
S
--
G
-
I
K
-
L
T
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
E
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
-
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------
323
Blastp_CBE
57.25
45%
-63
- C1 -
-
3F6X
7.0
-
SRC_CHICK
B:
[8-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------------
A
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
-
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------------
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
214
Blastp_CBE
57.07
46%
-65
- C1 -
-
2PL0
10.2
-
LCK_HUMAN
A:
[18-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
-------
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
------
N
----
G
---
H
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
M
--
S
---
P
D
---
A
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P-
S
--
G
-
I
K
-
L
T
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
E
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
-
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------
337
Blastp_CBE
56.95
45%
-66
- C1 -
-
2OIQ
10.5
-
SRC_CHICK
A:
[9-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
----------------
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
316
Blastp_CBE
56.95
45%
-64
- C1 -
-
3UQG
4.1
-
SRC_CHICK
A:
[11-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
-----------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
320
Blastp_CBE
56.94
45%
-62
- C1 -
-
3G6G
12.4
-
SRC_CHICK
A:
[9-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-----------------
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
402
Blastp_CBE
56.92
44%
-72
- C1 -
-
3CS9
11.5
-
ABL1_HUMAN
D:
[12-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------------------
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
335
Blastp_CBE
56.86
45%
-72
- C1 -
-
3D7T
8.4
-
SRC_CHICK
B:
[11-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------------
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
277
Blastp_CBE
56.62
45%
-73
- C1 -
-
3F3W
10.4
-
SRC_CHICK
A:
[10-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
333
Blastp_CBE
56.58
45%
-58
- C1 -
-
3DQX
4.1
-
SRC_CHICK
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
---------
Q
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
286
Blastp_CBE
56.57
45%
-57
- C1 -
-
2BDF
7.2
-
SRC_HUMAN
B:
[1-263]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------------
A
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
T-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
------------
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
318
Blastp_CBE
56.56
45%
-66
- C1 -
-
3UQF
6.9
-
SRC_CHICK
A:
[11-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
--------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
276
Blastp_CBE
56.52
45%
-72
- C1 -
-
3F3W
11.0
-
SRC_CHICK
B:
[11-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
250
Blastp_CBE
56.47
45%
-75
- C1 -
-
3F3V
10.3
-
SRC_CHICK
B:
[9-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
302
Blastp_CBE
56.45
45%
-63
- C1 -
-
4YBK
8.7
-
SRC_CHICK
A:
[9-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
---------------
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
306
Blastp_CBE
56.40
45%
-61
- C1 -
-
4U5J
5.9
-
SRC_CHICK
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
-----------
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
334
Blastp_CBE
56.39
45%
-61
- C1 -
-
3DQX
4.4
-
SRC_CHICK
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
-----------
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
267
Blastp_CBE
56.37
45%
-62
- C1 -
-
6HVE
5.1
-
?
A:
[9-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
---------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
231
Blastp_CBE
56.37
45%
-57
- C1 -
-
3KXZ
8.4
-
LCK_HUMAN
A:
[16-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
-------
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
------
N
----
G
---
H
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
M
--
S
---
P
D
---
A
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P-
S
--
G
-
I
K
-
L
T
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
E
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
-
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------
262
Blastp_CBE
56.23
45%
-63
- C1 -
-
3GEQ
6.4
-
SRC_CHICK
B:
[7-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
---------------
A
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
A
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
-----------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
421
Blastp_CBE
56.20
44%
-68
- C1 -
-
3OEZ
10.0
-
SRC_CHICK
A:
[10-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
307
Blastp_CBE
56.21
45%
-66
- C1 -
-
4O2P
8.1
-
SRC_CHICK
B:
[9-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
-
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
215
Blastp_CBE
56.23
45%
-57
- C1 -
-
4C3F
7.5
-
LCK_HUMAN
A:
[4-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
-------
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
------
N
----
G
---
H
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
M
--
S
---
P
D
---
A
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P-
S
--
G
-
I
K
-
L
T
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
N
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
------
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
-
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------
329
Blastp_CBE
56.20
45%
-60
- C1 -
-
3EN4
6.6
-
SRC_CHICK
B:
[10-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
--------------
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
263
Blastp_CBE
56.21
45%
-57
- C1 -
-
3GEQ
6.7
-
SRC_CHICK
A:
[7-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
---------------
A
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
A
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
297
Blastp_CBE
56.20
45%
-58
- C1 -
-
5XP5
4.1
-
SRC_CHICK
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
-----------
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
216
Blastp_CBE
56.14
45%
-58
- C1 -
-
3MPM
7.2
-
LCK_HUMAN
A:
[4-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
-------
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
------
N
----
G
---
H
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
M
--
S
---
P
D
---
A
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P-
S
--
G
-
I
K
-
L
T
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
N
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
------
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
-
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------
291
Blastp_CBE
56.10
45%
-62
- C1 -
-
4MXO
7.4
-
SRC_HUMAN
B:
[11-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
T-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
324
Blastp_CBE
56.08
45%
-64
- C1 -
-
3F6X
7.7
-
SRC_CHICK
A:
[8-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------------
A
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
-------
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
-------------
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
244
Blastp_CBE
56.07
45%
-67
- C1 -
-
3TZ8
11.3
-
SRC_CHICK
B:
[9-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
------------------
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
312
Blastp_CBE
56.01
45%
-65
- C1 -
-
4DGG
9.0
-
SRC_CHICK
A:
[9-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
206
Blastp_CBE
56.00
46%
-73
- C1 -
-
2OG8
10.6
-
LCK_HUMAN
A:
[3-260]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
-------
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
------
N
----
G
---
H
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
M
--
S
---
P
D
---
A
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P-
S
--
G
-
I
K
-
L
T
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
---------------------
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
-
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------
308
Blastp_CBE
55.98
45%
-63
- C1 -
-
4O2P
8.4
-
SRC_CHICK
A:
[10-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
--
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
--------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
292
Blastp_CBE
55.97
45%
-61
- C1 -
-
4MXO
7.4
-
SRC_HUMAN
A:
[10-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
T-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
---------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
210
Blastp_CBE
55.94
46%
-70
- C1 -
-
3BYU
11.0
-
LCK_HUMAN
A:
[14-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
-------
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
------
N
----
G
---
H
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
M
--
S
---
P
D
---
A
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P-
S
--
G
-
I
K
-
L
T
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
------------------
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
-
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------
295
Blastp_CBE
55.88
45%
-65
- C1 -
-
5XP7
4.6
-
SRC_CHICK
A:
[10-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
294
Blastp_CBE
55.88
45%
-59
- C1 -
-
5XP7
6.7
-
SRC_CHICK
B:
[9-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
---------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
472
Blastp_CBE
55.74
44%
-66
- C1 -
-
4MXY
6.9
-
SRC_HUMAN
B:
[11-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
L
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
T-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
470
Blastp_CBE
55.74
44%
-66
- C1 -
-
4MXZ
6.9
-
SRC_HUMAN
B:
[11-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
L
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
T-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
296
Blastp_CBE
55.74
45%
-58
- C1 -
-
5XP5
4.6
-
SRC_CHICK
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
-----------
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
304
Blastp_CBE
55.73
45%
-65
- C1 -
-
4YBJ
10.2
-
SRC_CHICK
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
303
Blastp_CBE
55.71
45%
-70
- C1 -
-
4YBJ
5.2
-
SRC_CHICK
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
-----
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
247
Blastp_CBE
55.69
45%
-70
- C1 -
-
3TZ7
9.1
-
SRC_CHICK
A:
[10-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
311
Blastp_CBE
55.68
45%
-67
- C1 -
-
4DGG
9.8
-
SRC_CHICK
B:
[9-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
--------------
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
-----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
462
Blastp_CBE
55.64
45%
-66
- C1 -
-
4MCV
6.0
-
SRC_CHICK
A:
[5-262]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
---------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
289
Blastp_CBE
55.62
45%
-58
- C1 -
-
4MXX
7.3
-
SRC_HUMAN
A:
[10-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
T-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
T
D
F
G
L
A
R
L
I
E
---------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
254
Blastp_CBE
55.56
45%
-72
- C1 -
-
3F3T
7.2
-
SRC_CHICK
A:
[10-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
298
Blastp_CBE
55.55
45%
-66
- C1 -
-
5K9I
7.0
-
SRC_CHICK
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
-----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
287
Blastp_CBE
55.52
45%
-60
- C1 -
-
2BDF
7.0
-
SRC_HUMAN
A:
[3-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
T-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
---------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
463
Blastp_CBE
55.49
44%
-66
- C1 -
-
1YOM
6.9
-
SRC_HUMAN
B:
[5-267]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------------
A
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
-
G
--
E
T-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
285
Blastp_CBE
55.47
45%
-59
- C1 -
-
2BDJ
10.1
-
SRC_HUMAN
A:
[3-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
T-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
---------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
327
Blastp_CBE
55.44
45%
-63
- C1 -
-
3EN5
6.5
-
SRC_CHICK
B:
[9-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
---------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
211
Blastp_CBE
55.42
46%
-74
- C1 -
-
3BYS
11.3
-
LCK_HUMAN
A:
[14-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
-------
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
------
N
----
G
---
H
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
M
--
S
---
P
D
---
A
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P-
S
--
G
-
I
K
-
L
T
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
---------------------
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
-
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------
452
Blastp_CBE
55.38
44%
-58
- C1 -
-
5SWH
6.5
-
SRC_CHICK
B:
[8-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------------
A
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
C
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
205
Blastp_CBE
55.42
46%
-69
- C1 -
-
2OG8
10.0
-
?
B:
[3-260]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
-------
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
------
N
----
G
---
H
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
M
--
S
---
P
D
---
A
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P-
S
--
G
-
I
K
-
L
T
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
--------------------
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
-
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------
301
Blastp_CBE
55.38
45%
-65
- C1 -
-
5J5S
9.5
-
SRC_CHICK
A:
[11-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
299
Blastp_CBE
55.40
45%
-63
- C1 -
-
5K9I
6.2
-
SRC_CHICK
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
454
Blastp_CBE
55.35
44%
-68
- C1 -
-
3G6H
11.7
-
SRC_CHICK
B:
[11-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
I
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
---------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
251
Blastp_CBE
55.39
45%
-73
- C1 -
-
3F3V
10.7
-
SRC_CHICK
A:
[10-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
248
Blastp_CBE
55.38
45%
-63
- C1 -
-
3G5D
7.6
-
SRC_CHICK
B:
[11-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
---
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
---
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
-----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
393
Blastp_CBE
55.35
45%
-67
- C1 -
-
5T0P
6.4
-
SRC_CHICK
B:
[11-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
C
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
-----------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
319
Blastp_CBE
55.27
45%
-58
- C1 -
-
3G6G
12.9
-
SRC_CHICK
B:
[9-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
------------------
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
453
Blastp_CBE
55.16
44%
-58
- C1 -
-
5SWH
6.6
-
SRC_CHICK
A:
[11-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
C
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
331
Blastp_CBE
55.16
45%
-66
- C1 -
-
3EL8
7.9
-
SRC_CHICK
A:
[11-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
-----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
253
Blastp_CBE
55.16
45%
-70
- C1 -
-
3F3U
6.2
-
SRC_CHICK
A:
[10-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
245
Blastp_CBE
55.16
45%
-69
- C1 -
-
3TZ8
10.9
-
SRC_CHICK
A:
[10-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
330
Blastp_CBE
55.06
45%
-69
- C1 -
-
3EN4
6.5
-
SRC_CHICK
A:
[11-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
--
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
242
Blastp_CBE
55.06
45%
-72
- C1 -
-
3TZ9
9.2
-
SRC_CHICK
B:
[10-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
314
Blastp_CBE
55.03
45%
-63
- C1 -
-
4AGW
9.6
-
SRC_CHICK
A:
[10-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
417
Blastp_CBE
55.01
44%
-62
- C1 -
-
3QLG
8.2
-
SRC_CHICK
A:
[11-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
420
Blastp_CBE
54.97
44%
-64
- C1 -
-
3OEZ
8.9
-
SRC_CHICK
B:
[9-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
473
Blastp_CBE
54.95
44%
-62
- C1 -
-
4MXY
6.6
-
SRC_HUMAN
A:
[10-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
L
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
T-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
---------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
317
Blastp_CBE
54.97
45%
-63
- C1 -
-
3UQF
7.8
-
SRC_CHICK
B:
[9-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
------------
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
271
Blastp_CBE
54.97
45%
-69
- C1 -
-
5D11
5.5
-
SRC_CHICK
A:
[11-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
-------------
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
457
Blastp_CBE
54.96
44%
-67
- C1 -
-
3SVV
6.0
-
SRC_CHICK
B:
[9-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
---
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
-
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
C
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
---------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
471
Blastp_CBE
54.95
44%
-62
- C1 -
-
4MXZ
6.6
-
SRC_HUMAN
A:
[10-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
L
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
T-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
---------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
322
Blastp_CBE
54.89
45%
-59
- C1 -
-
3F6X
7.8
-
SRC_CHICK
C:
[8-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------------
A
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
---------
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
-------------
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
433
Blastp_CBE
54.83
43%
-56
- C1 -
-
2HK5
9.4
-
HCK_HUMAN
A:
[10-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
-------
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
------
N
----
K
---
H
T
-
K
-
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
E
---
A
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
--
D
--
E
-
G
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
Y
T
--
A
R
E
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
-
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------
461
Blastp_CBE
54.82
45%
-63
- C1 -
-
4MCV
5.5
-
SRC_CHICK
B:
[5-262]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
-
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------------
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
313
Blastp_CBE
54.83
45%
-59
- C1 -
-
4AGW
10.2
-
SRC_CHICK
B:
[11-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
243
Blastp_CBE
54.82
45%
-69
- C1 -
-
3TZ9
9.7
-
SRC_CHICK
A:
[10-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
391
Blastp_CBE
54.78
45%
-70
- C1 -
-
3U51
8.7
-
SRC_CHICK
A:
[3-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
458
Blastp_CBE
54.75
44%
-55
- C1 -
-
3SVV
5.5
-
SRC_CHICK
A:
[10-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
-
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
C
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
246
Blastp_CBE
54.70
45%
-68
- C1 -
-
3TZ7
9.6
-
SRC_CHICK
B:
[10-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
288
Blastp_CBE
54.68
45%
-60
- C1 -
-
4MXX
7.8
-
SRC_HUMAN
B:
[11-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
T-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
T
D
F
G
L
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
269
Blastp_CBE
54.58
45%
-69
- C1 -
-
5D12
6.0
-
SRC_CHICK
A:
[10-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
-------
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
444
Blastp_CBE
54.53
43%
-65
- C1 -
-
5ZJ6
8.8
-
HCK_HUMAN
B:
[21-278]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
-------
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
------
N
----
K
---
H
T
-
K
-
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
E
---
A
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
--
D
--
E
-
G
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
Y
T
--
A
R
E
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
-
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------
305
Blastp_CBE
54.51
45%
-59
- C1 -
-
4U5J
5.6
-
SRC_CHICK
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
-----------
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
390
Blastp_CBE
54.43
45%
-66
- C1 -
-
3U51
8.6
-
B:
[3-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
249
Blastp_CBE
54.39
45%
-63
- C1 -
-
3G5D
8.1
-
SRC_CHICK
A:
[10-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
---
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
-------
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
-----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
240
Blastp_CBE
54.32
45%
-50
- C1 -
-
3KMM
8.0
-
LCK_HUMAN
A:
[17-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
-------
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
------
N
----
G
---
H
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
M
--
S
---
P
D
---
A
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P-
S
--
G
-
I
K
-
L
T
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
-
L
I
E
D
N
E
T
--
A
R
E
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
-
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------
524
Fugue
54.18
45%
-58
- C1 -
-
1BYG
7.5
-
CSK_HUMAN
A:
[15-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--
W
A
L
-------
N
M
K
E
L
--------
K
-
L
L
Q
T
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
------
R
----
G
----
N
-
K
-
V
A
V
K
C
I
K
---
N
--
D
---
A
Q
---
A
F
L
A
-
E
A
S
V
M
T
Q
L
R
H
S
N
L
V
Q
L
L
G
V
I
V
-
E
E
G
-
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
-
S
RG---
R
-
S
V
-
L
G
G
-
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
E
D
N
V
A
K
V
S
D
F
G
-------------------
L
-
L
P
V
K
W
T
A
P
E
A
L
R
E
K
K
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
R
V
P
Y
P
R
I
P
L
-
K
D
V
V
P
R
V
E
K
G
Y
K
M
D
A
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
Q
L
E
H
I
K
T
H
E
L
-
394
Blastp_CBE
54.14
45%
-71
- C1 -
-
5T0P
6.6
-
SRC_CHICK
A:
[10-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
C
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
-----------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
493
Blastp_CBE
54.05
44%
-57
- C1 -
-
3DQW
5.0
-
SRC_CHICK
A:
[8-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------------
A
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
I
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-
L
I
E
D
N
E
T
--
A
R
Q
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
300
Blastp_CBE
54.02
45%
-60
- C1 -
-
5J5S
8.7
-
SRC_CHICK
B:
[9-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
--
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
507
Blastp_CBE
53.99
44%
-66
- C1 -
-
5H2U
7.3
-
PTK6_HUMAN
B:
[2-254]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
-------
P
R
E
E
F
--------
T
-
L
C
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
------
K
----
D
---
R
V
-
Q
-
V
A
I
K
V
I
S
R
D
N
L
--
L
---
H
Q
---
Q
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
G
D
P
-
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
-
S
--
D
--
E
-
K
V
-
L
P
V
-
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
L
C
K
V
G
D
F
G
L
A
R
L
I
K
E
D
V
Y
L
--
S
H
--
D
H
N
-
I
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
-
P
G
M
S
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
-------------
222
Blastp_CBE
53.98
45%
-46
- C1 -
-
3AC8
6.2
-
LCK_HUMAN
A:
[14-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
-------
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
------
N
----
G
---
H
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
M
--
S
---
P
D
---
A
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P-
S
--
G
-
I
K
-
L
T
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
-
L
I
E
D
N
E
T
--
A
R
E
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
-
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------
449
Blastp_CBE
53.94
44%
-62
- C1 -
-
5TEH
4.8
-
SRC_CHICK
A:
[9-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
C
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
508
Blastp_CBE
53.86
44%
-66
- C1 -
-
5H2U
7.3
-
PTK6_HUMAN
A:
[2-254]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
-------
P
R
E
E
F
--------
T
-
L
C
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
------
K
----
D
---
R
V
-
Q
-
V
A
I
K
V
I
S
R
D
N
L
--
L
---
H
Q
---
Q
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
G
D
P
-
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
-
S
--
D
--
E
-
K
V
-
L
P
V
-
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
L
C
K
V
G
D
F
G
L
A
R
L
I
K
E
D
V
Y
L
--
S
H
--
D
H
N
-
I
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
-
P
G
M
S
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
-------------
445
Blastp_CBE
53.92
43%
-65
- C1 -
-
5ZJ6
9.3
-
HCK_HUMAN
A:
[21-278]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
-------
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
------
N
----
K
---
H
T
-
K
-
V
A
V
K
T
M
K
P
G
S
M
--
S
---
V
E
---
A
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
--
D
--
E
-
G
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
Y
T
--
A
R
E
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
-
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------
416
Blastp_CBE
53.90
44%
-62
- C1 -
-
3QLG
8.1
-
SRC_CHICK
B:
[9-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
-----
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
-----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
310
Blastp_CBE
53.86
45%
-74
- C1 -
-
4FIC
5.5
-
SRC_CHICK
A:
[8-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------------
A
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
---
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
----------------
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
293
Blastp_CBE
53.85
44%
-49
- C1 -
-
2DQ7
8.4
-
X:
[3-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
W
E
I
-------
P
R
E
S
L
--------
Q
-
L
I
K
R
L
G
N
G
Q
F
G
E
V
W
M
G
T
W
------
N
----
G
---
N
T
-
K
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
S
F
L
E
-
E
A
Q
I
M
K
K
L
K
H
D
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
D
G
--
E
--
G
-
R
A
-
L
K
L
-
P
N
L
V
D
M
A
A
Q
V
A
A
G
M
A
Y
I
E
R
M
N
Y
I
H
R
D
L
R
S
A
N
I
L
V
G
N
G
L
I
C
K
I
A
D
F
G
L
A
R
-
L
I
E
D
N
E
T
--
A
R
Q
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
V
T
K
G
R
V
P
Y
-
P
G
M
N
N
R
E
V
L
E
Q
V
E
R
G
Y
R
M
P
C
P
Q
D
C
P
I
S
L
H
E
L
M
I
H
C
W
K
K
D
P
E
E
R
P
T
F
E
Y
L
Q
S
F
L
E
--------
451
Blastp_CBE
53.82
44%
-62
- C1 -
-
5SYS
10.1
-
SRC_CHICK
A:
[11-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
C
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
464
Blastp_CBE
53.81
44%
-62
- C1 -
-
1YOM
7.1
-
SRC_HUMAN
A:
[5-267]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------------
A
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
-
G
--
E
T-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
492
Blastp_CBE
53.80
44%
-55
- C1 -
-
3DQW
4.1
-
SRC_CHICK
B:
[8-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------------
A
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
I
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-
L
I
E
D
N
E
T
--
A
R
Q
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
252
Blastp_CBE
53.78
45%
-66
- C1 -
-
3F3U
6.3
-
SRC_CHICK
B:
[10-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
----
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
220
Blastp_CBE
53.78
45%
-45
- C1 -
-
3ACK
5.3
-
LCK_HUMAN
A:
[14-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
-------
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
------
N
----
G
---
H
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
M
--
S
---
P
D
---
A
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P-
S
--
G
-
I
K
-
L
T
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
-
L
I
E
D
N
E
T
--
A
R
E
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
-
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------
431
Blastp_CBE
53.74
44%
-60
- C1 -
-
1YOL
6.7
-
SRC_HUMAN
B:
[9-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
-
G
--
E
T-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
225
Blastp_CBE
53.72
45%
-49
- C1 -
-
3AC3
5.5
-
LCK_HUMAN
A:
[14-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
-------
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
------
N
----
G
---
H
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
M
--
S
---
P
D
---
A
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P-
S
--
G
-
I
K
-
L
T
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
-
L
I
E
D
N
E
T
--
A
R
E
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
-
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------
224
Blastp_CBE
53.72
45%
-44
- C1 -
-
3AC4
5.2
-
LCK_HUMAN
A:
[14-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
-------
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
------
N
----
G
---
H
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
M
--
S
---
P
D
---
A
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P-
S
--
G
-
I
K
-
L
T
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
-
L
I
E
D
N
E
T
--
A
R
E
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
-
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------
279
Blastp_CBE
53.66
45%
-69
- C1 -
-
2QQ7
5.0
-
SRC_CHICK
A:
[10-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
-
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
-------------------
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
226
Blastp_CBE
53.66
45%
-48
- C1 -
-
3AC2
5.7
-
LCK_HUMAN
A:
[14-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
-------
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
------
N
----
G
---
H
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
M
--
S
---
P
D
---
A
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P-
S
--
G
-
I
K
-
L
T
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
-
L
I
E
D
N
E
T
--
A
R
E
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
-
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------
496
Blastp_CBE
53.61
43%
-25
- C1 -
-
2V7A
7.7
-
ABL1_HUMAN
B:
[9-270]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
432
Blastp_CBE
53.60
44%
-55
- C1 -
-
1YOL
4.4
-
SRC_HUMAN
A:
[6-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
-
G
--
E
T-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
239
Blastp_CBE
53.53
45%
-44
- C1 -
-
1QPC
4.8
-
?
A:
[8-265]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
-------
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
------
N
----
G
---
H
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
M
--
S
---
P
D
---
A
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P-
S
--
G
-
I
K
-
L
T
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
-
L
I
E
D
N
E
T
--
A
R
E
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
-
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------
237
Blastp_CBE
53.53
45%
-51
- C1 -
-
1QPJ
9.1
-
LCK_HUMAN
A:
[8-265]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
-------
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
------
N
----
G
---
H
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
M
--
S
---
P
D
---
A
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P-
S
--
G
-
I
K
-
L
T
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
-
L
I
E
D
N
E
T
--
A
R
E
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
-
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------
483
Blastp_CBE
53.38
44%
-31
- C1 -
-
2XYN
7.6
-
ABL2_HUMAN
A:
[27-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
--
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
P
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
E
E
V
T
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
------
150
Blastp_CBE
53.47
53%
-17
- C1 -
-
4UEU
4.0
-
?
A:
[6-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
-------
P
R
S
E
I
--------
T
-
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
------
R
----
N
Y--
N
I
-
E
-
V
A
V
K
T
L
K
E
G
T
M
--
S
---
V
E
---
E
F
L
Q
-
E
A
Q
I
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
T
K
E
P
P
-
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
-
D
C-
E
--
G
-
H
T
-
V
N
A
-
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
V
K
V
A
D
F
G
L
A
R
L
I
-------------
A
K
-
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
-
P
G
M
S
G
S
E
V
I
E
Q
V
E
R
G
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
------
281
Blastp_CBE
53.42
45%
-37
- C1 -
-
2ZVA
7.8
-
LYN_MOUSE
A:
[7-265]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
-------
P
R
E
S
I
--------
K
-
L
V
K
K
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
------
N
----
N
---
S
T
-
K
-
V
A
V
K
T
L
K
P
G
T
M
--
S
---
V
Q
---
A
F
L
E
-
E
A
N
L
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
V
V
T
K
E
E
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
--
D
EG
G
-
K
V
-
L
L
P
--
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
I
E
----
T
--
A
R
E
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
N
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
-
P
G
R
T
N
A
D
V
M
S
A
L
S
Q
G
Y
R
M
P
R
M
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
--------
260
Blastp_CBE
53.44
45%
-70
- C1 -
-
2HWO
4.6
-
SRC_CHICK
A:
[8-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------------
A
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
-
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
---------------
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
---
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
418
Blastp_CBE
53.40
44%
-61
- C1 -
-
3QLF
3.1
-
SRC_CHICK
B:
[11-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
--
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
-------------------
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
268
Blastp_CBE
53.43
45%
-72
- C1 -
-
5D12
6.4
-
SRC_CHICK
B:
[11-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
------------
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
208
Blastp_CBE
53.42
46%
-73
- C1 -
-
2OFV
10.3
-
?
B:
[13-270]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
-------
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
------
N
----
G
---
H
T
-
K
-
V
A
V
K
S
L
K
Q
G
-------------
A
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P-
S
--
G
-
I
K
-
L
T
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
---------------
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
-
P
-------
I
Q
N
L
E
-
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------
228
Blastp_CBE
53.41
45%
-46
- C1 -
-
2ZYB
7.5
-
LCK_HUMAN
A:
[14-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
-------
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
------
N
----
G
---
H
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
M
--
S
---
P
D
---
A
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P-
S
--
G
-
I
K
-
L
T
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
-
L
I
E
D
N
E
T
--
A
R
E
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
-
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------
270
Blastp_CBE
53.40
45%
-68
- C1 -
-
5D11
5.3
-
SRC_CHICK
B:
[10-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
-----------------
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
-----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
221
Blastp_CBE
53.38
45%
-49
- C1 -
-
3ACJ
5.0
-
LCK_HUMAN
A:
[14-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
-------
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
------
N
----
G
---
H
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
M
--
S
---
P
D
---
A
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P-
S
--
G
-
I
K
-
L
T
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
-
L
I
E
D
N
E
T
--
A
R
E
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
-
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------
491
Blastp_CBE
53.33
44%
-53
- C1 -
-
3DQW
5.3
-
SRC_CHICK
C:
[11-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
I
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-
L
I
E
D
N
E
T
--
A
R
Q
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
315
Blastp_CBE
53.30
45%
-58
- C1 -
-
3UQG
4.2
-
SRC_CHICK
B:
[9-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
----
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
------
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
-----------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
505
Blastp_CBE
53.31
44%
-64
- C1 -
-
5H2U
7.3
-
PTK6_HUMAN
D:
[2-254]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
-------
P
R
E
E
F
--------
T
-
L
C
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
------
K
----
D
---
R
V
-
Q
-
V
A
I
K
V
I
S
R
D
N
L
--
L
---
H
Q
---
Q
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
G
D
P
-
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
-
S
--
D
--
E
-
K
V
-
L
P
V
-
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
L
C
K
V
G
D
F
G
L
A
R
L
I
K
E
D
V
Y
L
--
S
H
--
D
H
N
-
I
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
-
P
G
M
S
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
-------------
229
Blastp_CBE
53.30
45%
-47
- C1 -
-
2ZM4
7.0
-
LCK_HUMAN
A:
[14-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
-------
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
------
N
----
G
---
H
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
M
--
S
---
P
D
---
A
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P-
S
--
G
-
I
K
-
L
T
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
-
L
I
E
D
N
E
T
--
A
R
E
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
-
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------
382
Blastp_CBE
53.25
44%
-17
- C1 -
-
2G2H
9.4
-
ABL1_HUMAN
A:
[10-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
P
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
407
Blastp_CBE
53.24
44%
-18
- C1 -
-
2HZI
10.7
-
ABL1_HUMAN
A:
[12-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
425
Blastp_CBE
53.19
44%
-27
- C1 -
-
3KF4
9.0
-
ABL1_MOUSE
A:
[8-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
----------
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
399
Blastp_CBE
53.15
44%
-19
- C1 -
-
4ZOG
7.7
-
ABL1_HUMAN
A:
[7-268]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
427
Blastp_CBE
53.12
44%
-23
- C1 -
-
2QOH
8.1
-
ABL1_MOUSE
A:
[8-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
-----
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
230
Blastp_CBE
53.15
45%
-46
- C1 -
-
2ZM1
7.1
-
LCK_HUMAN
A:
[14-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
-------
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
------
N
----
G
---
H
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
M
--
S
---
P
D
---
A
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P-
S
--
G
-
I
K
-
L
T
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
-
L
I
E
D
N
E
T
--
A
R
E
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
-
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------
506
Blastp_CBE
53.07
44%
-65
- C1 -
-
5H2U
7.2
-
PTK6_HUMAN
C:
[2-254]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
-------
P
R
E
E
F
--------
T
-
L
C
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
------
K
----
D
---
R
V
-
Q
-
V
A
I
K
V
I
S
R
D
N
L
--
L
---
H
Q
---
Q
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
G
D
P
-
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
-
S
--
D
--
E
-
K
V
-
L
P
V
-
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
L
C
K
V
G
D
F
G
L
A
R
L
I
K
E
D
V
Y
L
--
S
H
--
D
H
N
-
I
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
-
P
G
M
S
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
-------------
406
Blastp_CBE
53.12
44%
-26
- C1 -
-
2HZI
10.6
-
ABL1_HUMAN
B:
[12-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
----
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
290
Blastp_CBE
53.08
45%
-66
- C1 -
-
6ATE
4.9
-
SRC_HUMAN
A:
[10-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
-----------
P
E
---
A
F
---
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
T-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
284
Blastp_CBE
53.07
45%
-42
- C1 -
-
1QPD
7.6
-
?
A:
[8-265]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
-------
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
A
G
E
V
W
M
G
Y
Y
------
N
----
G
---
H
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
M
--
S
---
P
D
---
A
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P-
S
--
G
-
I
K
-
L
T
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
-
L
I
E
D
A
E
T
--
A
R
E
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
-
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------
377
Blastp_CBE
53.05
44%
-24
- C1 -
-
2F4J
7.6
-
ABL1_HUMAN
A:
[9-270]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
P
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
219
Blastp_CBE
53.04
45%
-47
- C1 -
-
3AD4
5.0
-
LCK_HUMAN
A:
[14-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
-------
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
------
N
----
G
---
H
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
M
--
S
---
P
D
---
A
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P-
S
--
G
-
I
K
-
L
T
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
-
L
I
E
D
N
E
T
--
A
R
E
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
-
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------
467
Blastp_CBE
52.97
44%
-27
- C1 -
-
3IK3
12.3
-
ABL1_MOUSE
B:
[8-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
446
Blastp_CBE
52.95
44%
-26
- C1 -
-
3DK3
8.6
-
ABL1_MOUSE
B:
[6-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
----
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
F
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
332
Blastp_CBE
52.98
45%
-61
- C1 -
-
3EL7
9.8
-
SRC_CHICK
A:
[10-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
-
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
----
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
450
Blastp_CBE
52.97
44%
-61
- C1 -
-
5SYS
10.4
-
SRC_CHICK
B:
[11-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
C
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
448
Blastp_CBE
52.96
44%
-66
- C1 -
-
5TEH
6.5
-
SRC_CHICK
B:
[9-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
C
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
487
Blastp_CBE
52.89
44%
-23
- C1 -
-
2GQG
7.7
-
ABL1_HUMAN
A:
[13-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
238
Blastp_CBE
52.95
45%
-45
- C1 -
-
1QPE
6.3
-
LCK_HUMAN
A:
[8-265]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
-------
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
------
N
----
G
---
H
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
M
--
S
---
P
D
---
A
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P-
S
--
G
-
I
K
-
L
T
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
-
L
I
E
D
N
E
T
--
A
R
E
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
-
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------
447
Blastp_CBE
52.94
44%
-21
- C1 -
-
3DK3
8.2
-
ABL1_MOUSE
A:
[6-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
------
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
F
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
459
Blastp_CBE
52.81
44%
-18
- C1 -
-
3QRJ
9.9
-
ABL1_HUMAN
B:
[13-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
265
Blastp_CBE
52.89
45%
-72
- C1 -
-
6HVF
6.2
-
?
A:
[10-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
------------------
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
266
Blastp_CBE
52.88
45%
-67
- C1 -
-
6HVE
4.9
-
?
B:
[11-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
--------------------
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
354
Blastp_CBE
52.86
44%
-20
- C1 -
-
1M52
10.4
-
ABL1_MOUSE
A:
[13-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
415
Blastp_CBE
52.81
44%
-12
- C1 -
-
2G1T
7.3
-
ABL1_HUMAN
A:
[10-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
255
Blastp_CBE
52.84
45%
-66
- C1 -
-
2QLQ
2.8
-
SRC_CHICK
B:
[10-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
-----------------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
349
Blastp_CBE
52.81
44%
-18
- C1 -
-
3K5V
11.3
-
ABL1_MOUSE
A:
[13-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
-
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
256
Blastp_CBE
52.80
45%
-70
- C1 -
-
2QLQ
6.1
-
SRC_CHICK
A:
[9-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
----------------------
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
490
Blastp_CBE
52.78
44%
-51
- C1 -
-
3DQW
5.1
-
SRC_CHICK
D:
[10-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
I
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-
L
I
E
D
N
E
T
--
A
R
Q
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
381
Blastp_CBE
52.76
44%
-19
- C1 -
-
2G2H
9.9
-
ABL1_HUMAN
B:
[10-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
P
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
482
Blastp_CBE
52.72
44%
-29
- C1 -
-
2XYN
7.5
-
ABL2_HUMAN
B:
[27-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
--
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
P
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
E
E
V
T
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
------
223
Blastp_CBE
52.71
45%
-44
- C1 -
-
3AC5
7.3
-
LCK_HUMAN
A:
[14-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
-------
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
------
N
----
G
---
H
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
M
--
S
---
P
D
---
A
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P-
S
--
G
-
I
K
-
L
T
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
-
L
I
E
D
N
E
T
--
A
R
E
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
-
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------
465
Blastp_CBE
52.70
44%
-26
- C1 -
-
3OY3
11.5
-
ABL1_MOUSE
B:
[8-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
424
Blastp_CBE
52.67
44%
-27
- C1 -
-
3KF4
9.4
-
ABL1_MOUSE
B:
[8-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
---
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
227
Blastp_CBE
52.65
45%
-45
- C1 -
-
3AC1
5.5
-
LCK_HUMAN
A:
[14-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
-------
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
------
N
----
G
---
H
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
M
--
S
---
P
D
---
A
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P-
S
--
G
-
I
K
-
L
T
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
-
L
I
E
D
N
E
T
--
A
R
E
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
-
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------
352
Blastp_CBE
52.64
44%
-18
- C1 -
-
1OPJ
11.1
-
ABL1_MOUSE
A:
[13-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
497
Blastp_CBE
52.57
43%
-23
- C1 -
-
2V7A
7.6
-
ABL1_HUMAN
A:
[9-270]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
217
Blastp_CBE
52.63
45%
-47
- C1 -
-
3AD6
5.2
-
LCK_HUMAN
A:
[14-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
-------
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
------
N
----
G
---
H
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
M
--
S
---
P
D
---
A
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P-
S
--
G
-
I
K
-
L
T
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
-
L
I
E
D
N
E
T
--
A
R
E
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
-
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------
476
Blastp_CBE
52.61
44%
-19
- C1 -
-
4XLI
7.3
-
B:
[3-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
----
G
E
V
Y
V
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
P
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
S
-
R
E
E
V
T
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
------
419
Blastp_CBE
52.60
44%
-75
- C1 -
-
3QLF
7.8
-
SRC_CHICK
A:
[11-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
-----------------
L
Q
-
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
274
Blastp_CBE
52.57
45%
-74
- C1 -
-
3LOK
4.4
-
SRC_CHICK
B:
[11-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
------------------------
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
---------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
234
Blastp_CBE
52.57
45%
-43
- C1 -
-
3BYO
9.5
-
?
A:
[8-265]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
-------
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
------
N
----
G
---
H
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
M
--
S
---
P
D
---
A
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P-
S
--
G
-
I
K
-
L
T
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
-
L
I
E
D
N
E
T
--
A
R
E
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
-
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------
498
Blastp_CBE
52.45
43%
-34
- C1 -
-
3D7T
7.9
-
CSK_HUMAN
A:
[7-268]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
A
L
-------
N
M
K
E
L
--------
K
-
L
L
Q
T
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
------
R
----
G
---
N
--
K
-
V
A
V
K
C
I
K
N
D
A
T
--
A
---
Q
----
A
F
L
A
-
E
A
S
V
M
T
Q
L
R
H
S
N
L
V
Q
L
L
G
V
I
V
E
E
K
G
G
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
-
S
--
R
--
G
-
R
S
V
L
G
G
-
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
E
D
N
V
A
K
V
S
D
F
G
----------------------
P
V
K
W
T
A
P
E
A
L
R
E
A
A
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
R
V
P
Y
-
P
R
I
P
L
K
D
V
V
P
R
V
E
K
G
Y
K
M
D
A
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
Q
L
E
H
I
K
T
H
E
L
H
376
Blastp_CBE
52.49
44%
-20
- C1 -
-
3QRI
10.6
-
ABL1_HUMAN
A:
[13-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
241
Blastp_CBE
52.47
45%
-39
- C1 -
-
5XY1
6.0
-
LYN_HUMAN
A:
[7-265]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
-------
P
R
E
S
I
--------
K
-
L
V
K
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
------
N
----
N
---
S
T
-
K
-
V
A
V
K
T
L
K
P
G
T
M
--
S
---
V
Q
---
A
F
L
E
-
E
A
N
L
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
V
V
T
R
E
E
P
-
I
Y
I
I
T
E
Y
M
A
K
G
S
L
L
D
F
L
K
-
S
--
D
EG
G
-
K
V
-
L
L
P
--
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
---------------
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
D
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
-
P
G
R
T
N
A
D
V
M
T
A
L
S
Q
G
Y
R
M
P
R
V
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
--------
353
Blastp_CBE
52.46
44%
-24
- C1 -
-
1M52
10.2
-
ABL1_MOUSE
B:
[13-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
481
Blastp_CBE
52.45
44%
-31
- C1 -
-
2XYN
5.8
-
ABL2_HUMAN
C:
[27-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
--
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
P
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
E
E
V
T
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
------
309
Blastp_CBE
52.44
45%
-69
- C1 -
-
4FIC
5.3
-
SRC_CHICK
B:
[11-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
-----------------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
468
Blastp_CBE
52.42
44%
-20
- C1 -
-
3IK3
12.1
-
ABL1_MOUSE
A:
[8-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
------
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
341
Blastp_CBE
52.35
44%
-16
- C1 -
-
6HD4
11.5
-
ABL1_MOUSE
A:
[13-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
-
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
412
Blastp_CBE
52.32
44%
-7
- C1 -
-
2G1T
7.2
-
ABL1_HUMAN
D:
[10-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
384
Blastp_CBE
52.28
44%
-17
- C1 -
-
2G2F
4.1
-
ABL1_HUMAN
A:
[10-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
P
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
209
Blastp_CBE
52.31
46%
-70
- C1 -
-
2OFV
10.3
-
LCK_HUMAN
A:
[13-270]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
-------
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
------
N
----
G
---
H
T
-
K
-
V
A
V
K
S
L
K
Q
G
---------------
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P-
S
--
G
-
I
K
-
L
T
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
---------------------
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
-
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------
278
Blastp_CBE
52.30
45%
-66
- C1 -
-
2QQ7
4.7
-
SRC_CHICK
B:
[11-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
----------------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
---------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
351
Blastp_CBE
52.28
44%
-21
- C1 -
-
1OPJ
11.3
-
ABL1_MOUSE
B:
[13-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
282
Blastp_CBE
52.24
45%
-36
- C1 -
-
2ZV9
5.7
-
LYN_MOUSE
A:
[7-265]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
-------
P
R
E
S
I
--------
K
-
L
V
K
K
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
------
N
----
N
---
S
T
-
K
-
V
A
V
K
T
L
K
P
G
T
M
--
S
---
V
Q
---
A
F
L
E
-
E
A
N
L
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
V
V
T
K
E
E
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
--
D
EG
G
-
K
V
-
L
L
P
--
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
I
----------
E
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
N
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
-
P
G
R
T
N
A
D
V
M
S
A
L
S
Q
G
Y
R
M
P
R
M
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
--------
477
Blastp_CBE
52.23
44%
-26
- C1 -
-
4XLI
8.1
-
ABL2_MOUSE
A:
[3-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
------
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
P
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
S
-
R
E
E
V
T
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
------
389
Blastp_CBE
52.20
44%
-25
- C1 -
-
2HZ0
9.8
-
ABL1_HUMAN
A:
[8-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
218
Blastp_CBE
52.18
45%
-41
- C1 -
-
3AD5
6.2
-
LCK_HUMAN
A:
[14-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
-------
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
------
N
----
G
---
H
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
M
--
S
---
P
D
---
A
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P-
S
--
G
-
I
K
-
L
T
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
-
L
I
E
D
N
E
T
--
A
R
E
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
-
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------
466
Blastp_CBE
52.16
44%
-23
- C1 -
-
3OY3
11.7
-
ABL1_MOUSE
A:
[8-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
413
Blastp_CBE
52.15
44%
-8
- C1 -
-
2G1T
7.4
-
ABL1_HUMAN
C:
[10-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
398
Blastp_CBE
52.13
44%
-25
- C1 -
-
4ZOG
8.1
-
ABL1_HUMAN
B:
[7-268]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
----
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
414
Blastp_CBE
52.12
44%
-11
- C1 -
-
2G1T
7.1
-
ABL1_HUMAN
B:
[10-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
486
Blastp_CBE
52.03
44%
-21
- C1 -
-
2GQG
8.3
-
ABL1_HUMAN
B:
[13-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
411
Blastp_CBE
52.08
44%
-21
- C1 -
-
3UE4
6.8
-
ABL1_HUMAN
A:
[10-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
499
Blastp_CBE
52.05
43%
-33
- C1 -
-
1BYG
7.5
-
CSK_HUMAN
A:
[16-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
A
L
-------
N
M
K
E
L
--------
K
-
L
L
Q
T
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
------
R
----
G
---
N
--
K
-
V
A
V
K
C
I
K
N
D
----
A
---
Q
----
A
F
L
A
-
E
A
S
V
M
T
Q
L
R
H
S
N
L
V
Q
L
L
G
V
I
V
E
E
--G
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
-
S
--
R
--
G
-
R
S
V
L
G
G
-
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
E
D
N
V
A
K
V
S
D
F
G
L
--------------------
L
P
V
K
W
T
A
P
E
A
L
R
E
K
K
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
R
V
P
Y
-
P
R
I
P
L
K
D
V
V
P
R
V
E
K
G
Y
K
M
D
A
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
Q
L
E
H
I
K
T
H
E
L
-
386
Blastp_CBE
52.04
44%
-21
- C1 -
-
4WA9
9.1
-
ABL1_HUMAN
B:
[9-270]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
374
Blastp_CBE
52.03
44%
-17
- C1 -
-
3QRK
8.6
-
ABL1_HUMAN
A:
[13-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
479
Blastp_CBE
51.94
44%
-19
- C1 -
-
3HMI
6.6
-
ABL2_HUMAN
A:
[27-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
P
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
E
E
V
T
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
------
275
Blastp_CBE
51.92
45%
-73
- C1 -
-
3LOK
2.1
-
SRC_CHICK
A:
[10-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
---
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
---------------------
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
494
Blastp_CBE
51.91
43%
-27
- C1 -
-
3DK7
7.8
-
ABL1_MOUSE
B:
[6-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
----
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
283
Blastp_CBE
51.88
45%
-37
- C1 -
-
2ZV8
4.1
-
LYN_MOUSE
A:
[7-265]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
-------
P
R
E
S
I
--------
K
-
L
V
K
K
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
------
N
----
N
---
S
T
-
K
-
V
A
V
K
T
L
K
P
G
T
M
--
S
---
V
Q
---
A
F
L
E
-
E
A
N
L
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
V
V
T
K
E
E
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
--
D
EG
G
-
K
V
-
L
L
P
--
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
I
---------
R
E
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
N
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
-
P
G
R
T
N
A
D
V
M
S
A
L
S
Q
G
Y
R
M
P
R
M
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
--------
469
Blastp_CBE
51.87
44%
-29
- C1 -
-
2Z60
8.5
-
ABL1_MOUSE
A:
[8-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
-----
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
258
Blastp_CBE
51.81
45%
-73
- C1 -
-
2HWP
3.1
-
SRC_CHICK
A:
[9-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
---
V
K
L
G
Q
G
C
-
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
------------------
F
L
Q
--
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
455
Blastp_CBE
51.75
44%
-25
- C1 -
-
4TWP
7.8
-
ABL1_HUMAN
B:
[3-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
435
Blastp_CBE
51.70
44%
-23
- C1 -
-
6NPV
11.5
-
ABL1_HUMAN
A:
[21-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
----------
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
495
Blastp_CBE
51.68
43%
-21
- C1 -
-
3DK7
8.3
-
ABL1_MOUSE
A:
[6-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
------
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
426
Blastp_CBE
51.70
44%
-22
- C1 -
-
2QOH
8.5
-
ABL1_MOUSE
B:
[8-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
---
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
423
Blastp_CBE
51.65
44%
-16
- C1 -
-
3KFA
12.8
-
ABL1_MOUSE
A:
[8-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
380
Blastp_CBE
51.69
44%
-21
- C1 -
-
2G2I
4.0
-
ABL1_HUMAN
A:
[10-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
---
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
P
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
259
Blastp_CBE
51.68
45%
-70
- C1 -
-
2HWO
3.3
-
SRC_CHICK
B:
[11-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
----------------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
422
Blastp_CBE
51.65
44%
-17
- C1 -
-
3KFA
12.8
-
ABL1_MOUSE
B:
[8-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
509
Blastp_CBE
51.64
43%
-41
- C1 -
-
6CZ4
10.2
-
PTK6_HUMAN
A:
[4-258]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--
A
E
R
-------
P
R
E
E
F
--------
T
-
L
C
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
------
K
----
D
---
R
V
-
Q
-
V
A
I
K
V
I
S
R
D
N
L
--
L
---
H
Q
---
Q
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
G
D
P
-
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
D
S
--
D
--
E
-
K
V
-
L
P
V
-
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
L
C
K
V
G
D
F
G
L
A
R
L
I
K
E
D
V
Y
L
--
S
H
-------
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
-
P
G
M
S
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
C
F
K
A
L
-------------
441
Blastp_CBE
51.55
44%
-20
- C1 -
-
3PYY
11.6
-
ABL1_HUMAN
A:
[21-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
------
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
339
Blastp_CBE
51.54
44%
-20
- C1 -
-
6HD6
11.7
-
ABL1_MOUSE
A:
[13-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
--
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
474
Blastp_CBE
51.52
45%
-65
- C1 -
-
4LGH
5.6
-
SRC_CHICK
B:
[4-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
-
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
-------------------
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
---------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
328
Blastp_CBE
51.51
45%
-66
- C1 -
-
3EN5
6.2
-
SRC_CHICK
A:
[13-270]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
-
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
-----------------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
-------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
442
Blastp_CBE
51.47
44%
-18
- C1 -
-
6BL8
6.3
-
ABL1_HUMAN
B:
[3-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
---
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
F
T
--
A
H
--
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
405
Blastp_CBE
51.43
44%
-14
- C1 -
-
3CS9
12.3
-
ABL1_HUMAN
A:
[12-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
------
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
437
Blastp_CBE
51.41
44%
-20
- C1 -
-
6NPU
11.4
-
ABL1_HUMAN
A:
[21-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
----------
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
410
Blastp_CBE
51.39
44%
-19
- C1 -
-
3UE4
7.6
-
ABL1_HUMAN
B:
[10-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
--
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
480
Blastp_CBE
51.35
44%
-12
- C1 -
-
3GVU
11.6
-
ABL2_HUMAN
A:
[27-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
P
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
E
E
V
T
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
---
G
D
T
Y
T
-------
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
------
460
Blastp_CBE
51.34
44%
-25
- C1 -
-
3QRJ
10.2
-
ABL1_HUMAN
A:
[13-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
-------
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
151
Blastp_CBE
51.33
53%
-7
- C1 -
-
4CSV
10.6
-
?
A:
[6-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
-------
P
R
S
E
I
--------
T
-
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
------
R
----
N
Y--
N
I
-
E
-
V
A
V
K
T
L
K
E
G
T
M
--
S
---
V
E
---
E
F
L
Q
-
E
A
Q
I
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
T
K
E
P
P
-
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
-
D
C---------
V
N
A
-
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
V
K
V
A
D
F
G
---------------------
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
-
P
G
M
S
G
S
E
V
I
E
Q
V
E
R
G
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
------
272
Blastp_CBE
51.31
45%
-70
- C1 -
-
5D10
6.4
-
SRC_CHICK
B:
[10-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
----------------------
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
---------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
257
Blastp_CBE
51.28
45%
-82
- C1 -
-
2HWP
2.7
-
SRC_CHICK
B:
[11-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
---
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
-----------------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
488
Blastp_CBE
51.27
45%
-58
- C1 -
-
4LGG
6.5
-
B:
[1-254]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
S
L
--------
R
-
L
E
V
K
L
G
----
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
----
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
485
Blastp_CBE
51.25
44%
-23
- C1 -
-
3DK6
7.8
-
ABL1_MOUSE
A:
[6-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
--
G
Q
F
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
-------
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
397
Blastp_CBE
51.21
44%
-16
- C1 -
-
2HIW
9.5
-
ABL1_HUMAN
A:
[10-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
443
Blastp_CBE
51.18
44%
-14
- C1 -
-
6BL8
7.3
-
ABL1_HUMAN
A:
[3-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
F
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
346
Blastp_CBE
51.18
44%
-19
- C1 -
-
3MS9
11.6
-
ABL1_MOUSE
B:
[13-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
---
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
356
Blastp_CBE
51.21
44%
-21
- C1 -
-
1IEP
11.1
-
ABL1_MOUSE
A:
[13-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
439
Blastp_CBE
51.20
44%
-20
- C1 -
-
6NPE
11.1
-
ABL1_HUMAN
A:
[21-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
----------
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
372
Blastp_CBE
51.19
44%
-17
- C1 -
-
2HYY
11.2
-
ABL1_HUMAN
B:
[8-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
-
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
345
Blastp_CBE
51.18
44%
-18
- C1 -
-
3MSS
11.6
-
ABL1_MOUSE
A:
[13-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
-----------
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
456
Blastp_CBE
51.17
44%
-20
- C1 -
-
4TWP
7.5
-
ABL1_HUMAN
A:
[3-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
-------
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
343
Blastp_CBE
51.15
44%
-18
- C1 -
-
3MSS
11.6
-
ABL1_MOUSE
C:
[13-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
-----------
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
379
Blastp_CBE
51.09
44%
-23
- C1 -
-
2G2I
3.7
-
ABL1_HUMAN
B:
[10-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
----
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
P
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
370
Blastp_CBE
51.11
44%
-16
- C1 -
-
2HYY
11.2
-
ABL1_HUMAN
D:
[8-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
--
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
325
Blastp_CBE
51.09
45%
-60
- C1 -
-
3EN7
5.7
-
SRC_CHICK
A:
[9-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
---
G
E
V
W
M
G
T
W
------
N
---------
T
-
R
-
V
A
I
K
T
L
K
P
---------------
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
264
Blastp_CBE
51.08
45%
-66
- C1 -
-
6HVF
6.7
-
?
B:
[11-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
------------------
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
400
Blastp_CBE
51.07
44%
-19
* C1 *
-
2E2B
12.0
-
ABL1_HUMAN
B:
[13-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
-------
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
------
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
344
Blastp_CBE
51.00
44%
-20
- C1 -
-
3MSS
11.5
-
ABL1_MOUSE
B:
[13-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
-----------
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
342
Blastp_CBE
50.96
44%
-19
- C1 -
-
3MSS
11.4
-
ABL1_MOUSE
D:
[13-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
-----------
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
475
Blastp_CBE
50.90
45%
-62
- C1 -
-
4LGH
6.7
-
SRC_CHICK
A:
[4-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
------
N
----
G
----
T
-
R
-
V
A
I
K
T
L
---------------------
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
261
Blastp_CBE
50.89
45%
-45
- C1 -
-
3A4O
7.7
-
LYN_HUMAN
X:
[8-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
-------
P
R
E
S
I
--------
K
-
L
V
K
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
------
N
----
N
---
S
T
-
K
-
V
A
V
K
T
L
K
P
G
T
M
--
S
---
V
Q
---
A
F
L
E
-
E
A
N
L
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
V
V
T
R
E
E
P
-
I
Y
I
I
T
E
Y
M
A
K
G
S
L
L
D
F
L
K
-
S
--
D
EG
G
-
K
V
-
L
L
P
--
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
-----------
E
-
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
D
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
-
P
G
R
T
N
A
D
V
M
T
A
L
S
Q
G
Y
R
M
P
R
V
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
--------
347
Blastp_CBE
50.86
44%
-18
- C1 -
-
3MS9
11.7
-
ABL1_MOUSE
A:
[13-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
-----------
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
375
Blastp_CBE
50.85
44%
-18
- C1 -
-
3QRI
9.7
-
ABL1_HUMAN
B:
[13-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
-------
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
326
Blastp_CBE
50.82
45%
-77
- C1 -
-
3EN6
6.0
-
SRC_CHICK
B:
[10-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
--
F
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
----------------------
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-----
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
------------------------
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
401
Blastp_CBE
50.78
44%
-27
- C1 -
-
2E2B
11.5
-
ABL1_HUMAN
A:
[13-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
----
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
----
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
516
Blastp_CBE
50.79
38%
-36
- C1 -
-
3V5Q
10.6
-
NTRK3_HUMAN
A:
[6-292]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
----------------
I
H
V
--
Q
H
I
-------
K
R
R
D
I
--------
V
-
L
K
R
E
L
------
K
V
F
L
A
E
C
YNLSPT
K
----
D
---
K
M
-
L
-
V
A
V
K
A
L
--
P
T
L
--
A
---
A
R
---
K
D
F
Q
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
G
D
G
D
P
-
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
-
A
--
H
--
G
P--E
L
G
L
-
S
Q
M
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
A
N
L
L
V
K
I
G
D
F
G
M
--
D
V
Y
S
T
D
Y
Y
--
R
----
T
M
-
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
Y
G
K
Q
P
W
-
F
Q
L
S
N
T
E
V
I
E
C
I
T
Q
G
R
V
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
I
Y
K
I
L
H
A
L
------
340
Blastp_CBE
50.78
44%
-20
- C1 -
-
6HD4
11.4
-
ABL1_MOUSE
B:
[13-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
---
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
355
Blastp_CBE
50.76
44%
-20
- C1 -
-
1IEP
11.4
-
ABL1_MOUSE
B:
[13-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
348
Blastp_CBE
50.73
44%
-18
- C1 -
-
3K5V
11.5
-
ABL1_MOUSE
B:
[13-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
---
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
338
Blastp_CBE
50.69
44%
-20
- C1 -
-
6HD6
11.5
-
ABL1_MOUSE
B:
[13-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
---
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
373
Blastp_CBE
50.67
44%
-17
- C1 -
-
2HYY
11.3
-
ABL1_HUMAN
A:
[8-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
-
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
273
Blastp_CBE
50.62
45%
-59
- C1 -
-
5D10
6.0
-
SRC_CHICK
A:
[11-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
--
W
E
I
-------
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
----
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
--
S
---
P
E
---
A
-----
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
371
Blastp_CBE
50.55
44%
-14
- C1 -
-
2HYY
11.4
-
ABL1_HUMAN
C:
[8-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
-
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
---
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
378
Blastp_CBE
50.54
44%
-15
- C1 -
-
5HU9
11.5
-
ABL1_HUMAN
A:
[12-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
------------
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
517
Blastp_CBE
50.51
38%
-17
- C1 -
-
2QOC
4.3
-
A:
[12-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
-------
D
A
T
N
I
--------
S
-
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
------
K
LPSK
K
---
E
I
-
S
-
V
A
I
K
T
L
K
V
G
Y
T
--
E
---
K
Q
RR-
D
F
L
G
-
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
-
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
-
K
--
H
--
D
-
A
Q
-
F
T
V
-
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
------------
K
-
I
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
-
W
E
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
------
489
Blastp_CBE
50.48
45%
-60
- C1 -
-
4LGG
5.0
-
SRC_CHICK
A:
[1-254]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
------
N
----
G
---
T
T
-
R
-
V
A
I
K
T
L
K
P
G
---------------
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
---
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
--
E
M-
G
-
K
Y
-
L
R
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
-
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------
153
Blastp_CBE
50.37
40%
-21
- C1 -
-
4XEY
8.1
-
ABL1_HUMAN
A:
[116-381]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----------------
Y
D
K
--
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
----
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C-
N
--
R
-
Q
E
-
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
513
Blastp_CBE
50.34
38%
-21
- C1 -
-
6IN0
4.7
-
?
A:
[4-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
-------
D
A
T
N
I
--------
S
-
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
------
K
LPSK
K
---
E
I
-
S
-
V
A
I
K
T
L
K
V
G
Y
T
--
E
---
K
Q
RR-
D
F
L
G
-
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
-
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
-
K
--
H
--
D
-
A
Q
-
F
T
V
-
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
----------------
I
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
-
W
E
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
------
368
Blastp_CBE
50.26
44%
-17
- C1 -
-
2HZ4
8.3
-
ABL1_HUMAN
B:
[8-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
-----
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
350
Blastp_CBE
50.24
44%
-19
- C1 -
-
2HZN
6.9
-
ABL1_MOUSE
A:
[13-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
---
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
--
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
396
Blastp_CBE
50.11
44%
-14
- C1 -
-
2HIW
9.5
-
ABL1_HUMAN
B:
[10-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
503
Blastp_CBE
50.03
44%
-29
- C1 -
-
5D7V
2.5
-
PTK6_HUMAN
B:
[2-254]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
-------
P
R
E
E
F
--------
T
-
L
C
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
------
K
----
D
---
R
V
-
Q
-
V
A
I
K
V
I
S
R
D
N
L
--
L
---
H
Q
---
Q
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
G
D
P
-
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
D
S
--
D
--
E
-
K
V
-
L
P
V
-
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
L
C
K
V
G
D
F
G
L
A
R
L
I
K
E
D
V
Y
L
--
S
H
--
D
H
N
-
I
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
-
P
G
M
S
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
-------------
357
Blastp_CBE
50.01
44%
-14
- C1 -
-
1FPU
7.5
-
ABL1_MOUSE
B:
[13-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-----
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
409
Blastp_CBE
49.99
44%
-21
- C1 -
-
4YC8
3.1
-
ABL1_HUMAN
A:
[10-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
------
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
----
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
515
Blastp_CBE
49.80
38%
-33
- C1 -
-
3V5Q
10.6
-
B:
[6-292]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
----------------
I
H
V
--
Q
H
I
-------
K
R
R
D
I
--------
V
-
L
K
R
E
L
G
---
F
-
K
V
F
L
A
E
C
YNLSPT
K
----
D
---
K
M
-
L
-
V
A
V
K
A
L
K
D
P
T
L
--
A
---
A
R
---
K
D
F
Q
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
--
G
D
P
-
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
-
A
--
H
--
G
P--E
L
G
L
-
S
Q
M
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
A
N
L
L
V
K
I
G
D
F
G
M
--
D
V
Y
S
T
D
Y
Y
--
R
----
T
M
-
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
Y
G
K
Q
P
W
-
F
Q
L
S
N
T
E
V
I
E
C
I
T
Q
G
R
V
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
I
Y
K
I
L
H
A
L
------
385
Blastp_CBE
49.74
44%
-19
- C1 -
-
3OXZ
11.9
-
ABL1_MOUSE
A:
[8-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
-----------
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
------------
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
511
Blastp_CBE
49.73
38%
-26
- C1 -
-
4YMJ
5.1
-
B:
[6-292]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
HV
Q
H
I
-------
K
R
R
D
I
--------
V
-
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
YNLSPT
K
----
D
---
K
M
-
L
-
V
A
V
K
A
L
K
D
P
T
L
--
A
---
A
R
---
K
D
F
Q
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
G
D
G
-
P
-
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
-
A
--
H
--
G
P-
G
E
L
G
L
-
S
Q
M
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
A
N
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
T
D
Y
Y
R
--
V
----
T
M
-
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
Y
G
K
Q
P
W
-
F
Q
L
S
N
T
E
V
I
E
C
I
T
Q
G
R
V
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
I
Y
K
I
L
H
A
L
------
484
Blastp_CBE
49.70
44%
-18
- C1 -
-
3DK6
5.7
-
ABL1_MOUSE
B:
[6-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
-------
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
-------
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
408
Blastp_CBE
49.68
44%
-17
- C1 -
-
4YC8
3.3
-
ABL1_HUMAN
B:
[10-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
------
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
358
Blastp_CBE
49.67
44%
-16
- C1 -
-
1FPU
9.2
-
ABL1_MOUSE
A:
[13-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
S
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
502
Blastp_CBE
49.57
44%
-29
- C1 -
-
5D7V
2.1
-
PTK6_HUMAN
C:
[2-254]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
-------
P
R
E
E
F
--------
T
-
L
C
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
------
K
----
D
---
R
V
-
Q
-
V
A
I
K
V
I
S
R
D
N
L
--
L
---
H
Q
---
Q
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
G
D
P
-
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
D
S
--
D
--
E
-
K
V
-
L
P
V
-
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
L
C
K
V
G
D
F
G
L
A
R
L
I
K
E
D
V
Y
L
--
S
H
--
D
H
N
-
I
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
-
P
G
M
S
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
-------------
518
Blastp_CBE
49.48
38%
-15
- C1 -
-
4TWO
6.1
-
A:
[29-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
-------
D
A
T
N
I
--------
S
-
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
------
K
LPSK
K
---
E
I
-
S
-
V
A
I
K
T
L
K
V
G
Y
T
--
E
---
K
Q
RR-
D
F
L
G
-
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
-
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
-
K
--
H
--
D
-
A
Q
-
F
T
V
-
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
-----------------
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
-
W
E
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
------
383
Blastp_CBE
49.54
44%
-13
- C1 -
-
2G2F
3.6
-
ABL1_HUMAN
B:
[10-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
-----
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
K
E
D
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
P
A
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
512
Blastp_CBE
49.48
38%
-28
- C1 -
-
4YMJ
7.0
-
NTRK3_HUMAN
A:
[6-292]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
HV
Q
H
I
-------
K
R
R
D
I
--------
V
-
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
YNLSPT
K
----
D
---
K
M
-
L
-
V
A
V
K
A
L
K
D
P
T
L
--
A
---
A
R
---
K
D
F
Q
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
G
D
G
D
P
-
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
-
A
--
H
--
G
P-
G
E
L
G
L
-
S
Q
M
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
A
N
L
L
V
K
I
G
D
F
G
---
D
V
Y
T
D
Y
Y
R
--
V
----
T
M
-
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
Y
G
K
Q
P
W
-
F
Q
L
S
N
T
E
V
I
E
C
I
T
Q
G
R
V
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
I
Y
K
I
L
H
A
L
------
521
Blastp_CBE
49.37
38%
-14
- C1 -
-
4P5Q
6.4
-
A:
[29-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
-------
D
A
T
N
I
--------
S
-
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
------
K
LPSK
K
---
E
I
-
S
-
V
A
I
K
T
L
K
V
G
Y
T
--
E
---
K
Q
RR-
D
F
L
G
-
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
-
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
-
K
--
H
--
D
-
A
Q
-
F
T
V
-
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
------------------
I
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
-
W
E
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
------
500
Blastp_CBE
49.28
44%
-27
- C1 -
-
5DA3
6.0
-
PTK6_HUMAN
A:
[2-254]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
-------
P
R
E
E
F
--------
T
-
L
C
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
------
K
----
D
---
R
V
-
Q
-
V
A
I
K
V
I
S
R
D
N
L
--
L
---
H
----
Q
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
G
D
P
-
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
D
S
--
D
--
E
-
K
V
-
L
P
V
-
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
L
C
K
V
G
D
F
G
L
A
R
L
I
K
E
D
V
Y
L
--
S
H
--
D
H
N
-
I
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
-
P
G
M
S
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
-------------
403
Blastp_CBE
49.12
44%
-15
- C1 -
-
3CS9
11.8
-
ABL1_HUMAN
C:
[12-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
-------
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
----------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
501
Blastp_CBE
48.99
44%
-28
- C1 -
-
5D7V
2.3
-
PTK6_HUMAN
D:
[2-254]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
-------
P
R
E
E
F
--------
T
-
L
C
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
------
K
----
D
---
R
V
-
Q
-
V
A
I
K
V
I
S
R
D
N
L
--
L
---
H
Q
---
Q
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
G
D
P
-
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
D
S
--
D
--
E
-
K
V
-
L
P
V
-
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
L
C
K
V
G
D
F
G
L
A
R
L
I
K
E
D
V
Y
L
--
S
H
--
D
H
N
-
I
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
-
P
G
M
S
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
-------------
436
Blastp_CBE
48.89
44%
-15
- C1 -
-
6NPU
11.4
-
ABL1_HUMAN
B:
[21-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
-----------
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
------------------
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
522
Blastp_CBE
48.82
38%
-11
- C1 -
-
4P4C
6.0
-
A:
[29-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
-------
D
A
T
N
I
--------
S
-
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
------
K
LPSK
K
---
E
I
-
S
-
V
A
I
K
T
L
K
V
G
Y
T
--
E
---
K
Q
RR-
D
F
L
G
-
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
-
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
-
K
--
H
--
D
-
A
Q
-
F
T
V
-
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
-----------------------
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
-
W
E
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
------
504
Blastp_CBE
48.73
44%
-28
- C1 -
-
5D7V
2.1
-
PTK6_HUMAN
A:
[2-254]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
-------
P
R
E
E
F
--------
T
-
L
C
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
------
K
----
D
---
R
V
-
Q
-
V
A
I
K
V
I
S
R
D
N
L
--
L
---
H
Q
---
Q
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
G
D
P
-
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
D
S
--
D
--
E
-
K
V
-
L
P
V
-
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
L
C
K
V
G
D
F
G
L
A
R
L
I
K
E
D
V
Y
L
--
S
H
--
D
H
N
-
I
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
-
P
G
M
S
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
-------------
438
Blastp_CBE
48.73
44%
-18
- C1 -
-
6NPE
11.0
-
ABL1_HUMAN
B:
[21-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
-----------
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
---------------------
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
404
Blastp_CBE
48.68
44%
-12
- C1 -
-
3CS9
12.1
-
ABL1_HUMAN
B:
[12-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
---
T
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
----------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
440
Blastp_CBE
48.56
44%
-13
- C1 -
-
3PYY
11.4
-
ABL1_HUMAN
B:
[21-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
-----------
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
------------------
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
434
Blastp_CBE
48.50
44%
-13
- C1 -
-
6NPV
11.4
-
ABL1_HUMAN
B:
[21-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
-----------
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
------------------
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
519
Blastp_CBE
48.19
38%
-11
- C1 -
-
4TWN
11.3
-
A:
[29-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
-------
D
A
T
N
I
--------
S
-
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
------
K
LPSK
K
---
E
I
-
S
-
V
A
I
K
T
L
K
V
G
Y
T
--
E
---
K
Q
RR-
D
F
L
G
-
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
-
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
-
K
--
H
--
D
-
A
Q
-
F
T
V
-
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
----------------
K
-
I
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
-
W
E
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
------
520
Blastp_CBE
48.15
38%
-14
- C1 -
-
4P5Z
9.5
-
A:
[29-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
-------
D
A
T
N
I
--------
S
-
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
------
K
LPSK
K
---
E
I
-
S
-
V
A
I
K
T
L
K
V
G
Y
T
--
E
---
K
Q
RR-
D
F
L
G
-
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
-
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
-
K
--
H
--
D
-
A
Q
-
F
T
V
-
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
-----------------------
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
-
W
E
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
------
388
Blastp_CBE
47.30
44%
-21
- C1 -
-
2HZ0
10.1
-
ABL1_HUMAN
B:
[8-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
------
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
K
T
L
----
M
--
E
---
V
E
---
E
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
--
C
--
N
-
R
Q
E
V
N
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
---------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
-
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
387
Blastp_CBE
45.44
44%
-9
- C1 -
-
4WA9
6.8
-
ABL1_HUMAN
A:
[10-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
-------
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------
K
----
K
Y--
S
L
-
T
-
V
A
V
-----------------------------
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
----
I
I
T
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F
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T
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N
L
L
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L
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--
C
--
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V
V
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L
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H
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L
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M
T
G
D
T
Y
T
--
A
H
A
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A
K
-
F
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P
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L
A
Y
N
K
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K
S
D
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A
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L
L
W
E
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A
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P
Y
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P
G
I
D
L
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Q
V
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L
L
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D
Y
R
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C
P
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W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------
-
* C *
-
:
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