@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Screening
Virtual Screening Score
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : BRSK1_HUMAN: (2020-09-05 )
MSSGAKEGGGGSPAYHLPHPHPHPPQHAQYVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDGRRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVEPEKRLSLEQIQKHPWYLGGKHEPDPCLEPAPGRRVAMRSLPSNGELDPDVLESMASLGCFRDRERLHRELRSEEENQEKMIYYLLLDRKERYPSCEDQDLPPRNDVDPPRKRVDSPMLSRHGKRRPERKSMEVLSITDAGGGGSPVPTRRALEMAQHSQRSRSVSGASTGLSSSPLSSPRSPVFSFSPEPGAGDEARGGGSPTSKTQTLPSRGPRGGGAGEQPPPPSARSTPLPGPPGSPRSSGGTPLHSPLHTPRASPTGTPGTTPPPSPGGGVGGAAWRSRLNSIRNSFLGSPRFHRRKMQVPTAEEMSSLTPESSPELAKRSWFGNFISLDKEEQIFLVLKDKPLSSIKADIVHAFLSIPSLSHSVLSQTSFRAEYKASGGPSVFQKPVRFQVDISSSEGPEPSPRRDGSGGGGIYSVTFTLISGPSRRFKRVVETIQAQLLSTHDQPSVQALADEKNGAQTRPAGAPPRSLQPPPGRPDPELSSSPRRGPPKDKKLLATNGTPLP
Atome Classification :
(400 SA)
.........10........20....----..--..30........40........50......----..60...--....--.-70.-----..----.-.---....---80........-90........100.......110.......120.......130-.........140.......150.......160.---.---...---.----.---170.....-.-.-180-..-.--.-..-...190........200--......-----.210----........220.......230--.--....-----..240..--..--.--..---250.----.-.--..-------..-------..260---........270..-----.....280.------.---.--------....--290.---......300....---...310.......320...-....330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(pKd)
(pKd)
(Uniprot)
MSSGAKEGGGGSPAYHLPHPHPHPP----QH--AQYV
G
P
Y
R
L
E
K
T
LGKGQT
G
L
V
K
L
G
V
H
C
ITG----
Q
K
V
A
I
K
I
--V
N
R
E
--
K
-
L
-
S
-----
E
S
----
V
-
L
---
M
K
V
E
---
R
E
I
A
I
L
K
L
IE-HP
H
V
L
K
L
H
D
V
YEN
K
K
Y
L
Y
L
V
L
EHVSG
G
E
L
F
D
Y
L
V
KKGRL
T
P
---
K
E
A
R
K
F
F
R
Q
I
V
S
A
L
D
F
C
H
S
Y
S
I
C
HRDLKPE
N
L
L
---L---DEK---N----
N
---
I
R
I
A
DFG
M
-
A
-
S
-
L
---
Q
V
-
G
--
D
-
S
L
-
L
ETS-CGSPHYAC
P
E
VI--KGEKYD-----GRR-----A
D
M
W
S
C
G
V
I
L
F
A
L
L
VGALPFD--
D
--
D
N
L
R
-----
Q
L
L
E
K
V
K
--
R
G
--V--FH---M--P----H-F--IP-------P
D
-------
C
Q
S
L
----
L
R
G
M
I
EVE
P
E
KRL-----
S
L
E
Q
I
Q
KHP------W---Y--------LGGK--HEPD---PCLEPAPGR
R
V
A
M
---RSLPSNGEL
D
P
D
V
L
E
S
M
A
S-LGC
F
R
D
R
E
R
L
H
R
E
L
RSEEENQ
E
K
M
I
Y
Y
L
L
LDRKERYPSCEDQDLPPRNDVDP
P
R
K
RVD
S
P
M
L
S
R
HGKRRPERKS
M
E
V
L
S
I
TDAGGGGSPV
P
T
R
R
A
L
E
M
A
Q
H
S
Q
R
SRSVSGASTGLSSSPLSSPRSP
V
F
S
FSPEPGAGDEARGGGSPTSKTQTLPSRGPRGGGAGEQPPPPSARSTPLPGPPGSPRSSGGTPLHSPLHTPRASPTGTPGTTPPPSPGGGV
G
G
A
A
W
R
S
R
L
N
S
I
R
N
SFLGSPRFHRRKMQVP
T
A
E
E
M
S
SLTPESS
P
E
L
A
K
R
S
WFGNFISLDKE
E
Q
I
F
L
V
LKDK
P
L
S
S
I
K
A
D
I
V
H
A
F
L
SIP
S
L
S
H
S
V
L
S
QTS
F
R
A
E
YKASGG
P
S
V
FQKP
V
R
F
Q
V
DISSSEGPEPSPRRDGSGGG
G
I
Y
S
V
T
F
T
L
ISG
P
S
R
R
F
K
R
V
V
E
T
I
Q
A
Q
L
L
STHDQP
S
V
Q
A
L
ADEKNGAQTRPAGAPPRSLQPPPGRPDPELSSSPRRGPPKD
K
K
L
LATNGTPLP
1
PsiBlast_PDB
95.02
83%
-145
- C2 -
-
4YOM
-
-
?
B:
[13-342]
------------------------------
H
--
A
Q
Y
V
G
P
Y
R
L
E
K
T
L
G
K
G
Q
T
G
L
V
K
L
G
I
H
C
V
T
C
----
Q
K
V
A
I
K
I
--
V
N
R
E
--
K
-
L
-
S
-----
E
S
----
V
-
L
---
M
K
V
E
---
R
E
I
A
I
L
K
L
I
E
-
H
P
H
V
L
K
L
H
D
V
Y
E
N
K
K
Y
L
Y
L
V
L
E
H
V
S
G
G
E
L
F
D
Y
L
V
K
K
G
R
L
T
P
---
K
E
A
R
K
F
F
R
Q
I
I
S
A
L
D
F
C
H
S
H
S
I
C
H
R
D
L
K
P
E
N
L
L
---
L
---
D
E
R
---
N
----
N
---
I
R
I
A
D
F
G
M
-
A
-
S
-
L
---
Q
V
-
G
--
D
-
S
L
-
L
E
T
S
-
C
G
S
P
H
Y
A
C
P
E
V
I
--
R
G
E
K
Y
D
-----
G
R
K
-----
A
D
V
W
S
C
G
V
I
L
F
A
L
L
V
G
A
L
P
F
D
--
D
--
D
N
L
R
-----
Q
L
L
E
K
V
K
--
R
G
--
V
--
F
H
---
M
--
P
----
H
-
F
--
I
P
-------
P
D
-------
C
Q
S
L
----
L
R
G
M
I
E
V
D
A
A
R
R
L
-----
T
L
E
H
I
Q
K
H
I
------
W
---
Y
--------
I
G
G
K
--
N
---------------
K
V
Q
I
---
R
S
L
P
S
L
E
D
I
D
P
D
V
L
D
S
M
H
S
-
L
G
C
F
R
D
R
N
K
L
L
Q
D
L
L
S
E
E
E
N
Q
E
K
M
I
Y
F
L
L
L
D
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
74.44
46%
-118
- C2 -
-
3IEC
-
-
MARK2_HUMAN
A:
[5-317]
-----------------------------------
H
I
G
N
Y
R
L
L
K
T
I
G
----
A
K
V
K
L
A
R
H
I
L
T
G
----
K
E
V
A
V
K
I
--
I
D
K
T
--
Q
-
L
-
N
-----
S
S
----
S
-
L
---
Q
K
L
F
---
R
E
V
R
I
M
K
V
L
N
-
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
W
M
K
E
---
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
D
---
M
----
N
---
I
K
I
A
D
F
G
F
-
S
-
N
-
E
---
F
T
-
F
--
G
-
N
K
-
L
D
T
F
-
C
G
S
P
P
Y
A
A
P
E
L
F
--
Q
G
K
K
Y
D
-----
G
P
E
-----
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
--
G
--
Q
N
L
K
-----
E
L
R
E
R
V
L
--
R
G
--
K
--
Y
R
---
I
--
P
----
F
-
Y
--
M
S
-------
T
D
-------
C
E
N
L
----
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
R
------
W
---
M
--------
N
V
G
---
H
E
D
D
ELK
P
Y
V
E
P
L
P
D
Y
K
---------------
D
P
R
R
T
E
L
M
V
S
-
M
G
Y
--
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
-
E
V
M
A
T
Y
L
L
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
73.17
46%
-112
- C2 -
-
5KZ8
7.5
-
MARK2_HUMAN
A:
[31-345]
-----------------------------------
H
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
----
K
E
V
A
V
K
I
--
I
D
K
T
--
Q
-
L
-
N
-----
S
S
----
S
-
L
---
Q
K
L
F
---
R
E
V
R
I
M
K
V
L
N
-
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
---
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
D
---
M
----
N
---
I
K
I
A
D
F
G
--------------------------
C
G
S
P
P
Y
A
A
P
E
L
F
--
Q
G
K
K
Y
D
-----
G
P
E
-----
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
--
G
--
Q
N
L
K
-----
E
L
R
E
R
V
L
--
R
G
--
K
--
Y
R
---
I
--
P
----
F
-
Y
--
M
S
-------
T
D
-------
C
E
N
L
----
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
R
------
W
---
M
--------
N
V
G
---
H
E
D
D
ELK
P
Y
V
E
P
L
P
D
Y
K
---------------
D
P
R
R
T
E
L
M
V
S
-
M
G
Y
--
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
-
E
V
M
A
T
Y
L
L
L
G
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Blastp_CBE
72.91
47%
-105
- C2 -
-
5EAK
8.0
-
MARK2_HUMAN
B:
[15-327]
-------------------------------------
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
----
K
E
V
A
V
K
I
--
I
D
K
T
--
Q
-
L
-
N
-----
S
S
----
S
-
L
---
Q
K
L
F
---
R
E
V
R
I
M
K
V
L
N
-
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
---
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
D
---
M
----
N
---
I
K
I
A
D
F
G
------------------------
F
-
C
G
S
P
P
Y
A
A
P
E
L
F
--
Q
G
K
K
Y
D
-----
G
P
E
-----
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
--
G
--
Q
N
L
K
-----
E
L
R
E
R
V
L
--
R
G
--
K
--
Y
R
---
I
--
P
----
F
-
Y
--
M
S
-------
T
D
-------
C
E
N
L
----
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
R
------
W
---
M
--------
N
V
G
---
H
E
D
D
ELK
P
Y
V
E
P
L
P
D
Y
K
---------------
D
P
R
R
T
E
L
M
V
S
-
M
G
Y
--
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
-
E
V
M
A
T
Y
L
L
L
G
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Blastp_CBE
72.68
47%
-116
- C2 -
-
5KZ8
7.3
-
MARK2_HUMAN
B:
[31-345]
-----------------------------------
H
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
----
K
E
V
A
V
K
I
--
I
D
K
T
--
Q
-
L
-
N
-----
S
S
----
S
-
L
---
Q
K
L
F
---
R
E
V
R
I
M
K
V
L
N
-
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
---
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
D
---
M
----
N
---
I
K
I
A
D
F
----------------------------
G
S
P
P
Y
A
A
P
E
L
F
--
Q
G
K
K
Y
D
-----
G
P
E
-----
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
--
G
--
Q
N
L
K
-----
E
L
R
E
R
V
L
--
R
G
--
K
--
Y
R
---
I
--
P
----
F
-
Y
--
M
S
-------
T
D
-------
C
E
N
L
----
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
R
------
W
---
M
--------
N
V
G
---
H
E
D
D
ELK
P
Y
V
E
P
L
P
D
Y
K
---------------
D
P
R
R
T
E
L
M
V
S
-
M
G
Y
--
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
-
E
V
M
A
T
Y
L
L
L
G
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
72.22
46%
-116
- C2 -
-
5KZ7
7.6
-
MARK2_HUMAN
A:
[31-345]
-----------------------------------
H
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
----
K
E
V
A
V
K
I
--
I
D
K
T
--
Q
-
L
-
N
-----
S
S
----
S
-
L
---
Q
K
L
F
---
R
E
V
R
I
M
K
V
L
N
-
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
---
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
D
---
M
----
N
---
I
K
I
A
D
F
----------------------------
G
S
P
P
Y
A
A
P
E
L
F
--
Q
G
K
--
D
-----
G
P
E
-----
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
------
N
L
K
-----
E
L
R
E
R
V
L
--
R
G
--
K
--
Y
R
---
I
--
P
----
F
-
Y
--
M
S
-------
T
D
-------
C
E
N
L
----
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
R
------
W
---
M
--------
N
V
G
---
H
E
D
D
ELK
P
Y
V
E
P
L
P
D
Y
K
---------------
D
P
R
R
T
E
L
M
V
S
-
M
G
Y
--
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
-
E
V
M
A
T
Y
L
L
L
G
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
582
HHSearch
71.89
44%
-116
- C2 -
-
2QNJ
-
-
MARK3_HUMAN
B:
[47-367]
------------------------
S
----
D
E
--
Q
P
H
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
----
R
E
V
A
I
K
I
--
I
D
K
T
--
Q
-
L
-
N
-----
P
T
----
S
-
L
---
Q
K
L
F
---
R
E
V
R
I
M
K
I
L
N
-
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
I
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
---
K
E
A
R
S
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
R
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
D
---
M
----
N
---
I
K
I
A
D
F
G
F
-
S
-
N
-
E
---
F
T
-------
K
-
L
D
T
F
-
C
G
S
P
P
Y
A
A
P
E
L
F
--
Q
G
K
K
Y
D
-----
G
P
E
-----
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
--
G
--
Q
N
L
K
-----
E
L
R
E
R
V
L
--
R
G
--
K
--
Y
R
---
I
--
P
----
F
-
Y
--
M
S
-------
T
D
-------
C
E
N
L
----
L
K
R
F
L
V
L
N
P
I
K
R
G
-----
T
L
E
Q
I
M
K
D
R
------
W
---
I
--------
N
A
G
H
--
E
E
D
E
----
L
-
K
P
-----------
F
V
E
P
E
L
D
I
S
D
Q
K
R
I
D
I
M
V
G
-
M
G
Y
--
S
Q
E
E
I
Q
E
S
L
S
K
M
K
Y
D
E
I
T
A
T
Y
L
L
L
G
R
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Blastp_CBE
71.68
47%
-118
- C2 -
-
5KZ7
7.2
-
MARK2_HUMAN
B:
[31-345]
-----------------------------------
H
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
----
K
E
V
A
V
K
I
--
I
D
K
T
--
Q
-
L
-
N
-----
S
S
----
S
-
L
---
Q
K
L
F
---
R
E
V
R
I
M
K
V
L
N
-
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
---
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
D
---
M
----
N
---
I
K
I
A
D
F
----------------------------
G
S
P
P
Y
A
A
P
E
L
F
--
Q
G
K
--
D
-----
G
P
E
-----
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
------
N
L
K
-----
E
L
R
E
R
V
L
--
R
G
--
K
--
Y
R
---
I
--
P
----
F
-
Y
--
M
S
-------
T
D
-------
C
E
N
L
----
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
R
------
W
---
M
--------
N
V
G
---
H
E
D
D
ELK
P
Y
V
E
P
L
P
D
Y
K
---------------
D
P
R
R
T
E
L
M
V
S
-
M
G
Y
--
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
-
E
V
M
A
T
Y
L
L
L
G
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
71.23
46%
-100
- C2 -
-
5EAK
7.5
-
MARK2_HUMAN
A:
[13-326]
-----------------------------------
H
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
----
K
E
V
A
V
K
I
--
I
D
K
T
--
Q
-
L
-
N
-----
S
S
----
S
-
L
---
Q
K
L
F
---
R
E
V
R
I
M
K
V
L
N
-
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
---
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
D
---
M
----
N
---
I
K
I
A
D
F
G
F
-
S
---------------------
F
-
C
G
S
P
P
Y
A
A
P
E
L
F
--
Q
G
K
K
Y
D
-----
G
P
E
-----
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
--
G
--
Q
N
L
K
-----
E
L
R
E
R
V
L
--
R
G
--
K
--
Y
R
---
I
--
P
----
F
-
Y
--
M
S
-------
T
D
-------
C
E
N
L
----
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
R
------
W
---
M
--------
N
V
G
---
H
E
D
D
ELK
P
Y
V
E
P
L
P
D
Y
K
---------------
D
P
R
R
T
E
L
M
V
S
-
M
G
Y
--
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
-
E
V
M
A
T
Y
L
L
L
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
71.01
46%
-112
- C2 -
-
1ZMW
-
-
MARK2_RAT
A:
[49-363]
-----------------------------------
H
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
----
K
E
V
A
V
K
I
--
I
D
K
T
--
Q
-
L
-
N
-----
S
S
----
S
-
L
---
Q
K
L
F
---
R
E
V
R
I
M
K
V
L
N
-
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
---
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
D
---
M
----
N
---
I
K
I
A
------------------------
L
D
A
F
-
C
G
A
P
P
Y
A
A
P
E
L
F
--
Q
G
K
K
Y
D
-----
G
P
E
-----
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
--
G
--
Q
N
L
K
-----
E
L
R
E
R
V
L
--
R
G
--
K
--
Y
R
---
I
--
P
----
F
-
Y
--
M
S
-------
T
D
-------
C
E
N
L
----
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
R
------
W
---
M
--------
N
V
G
---
H
E
D
D
ELK
P
Y
V
E
P
L
P
D
Y
K
---------------
D
P
R
R
T
E
L
M
V
S
-
M
G
Y
--
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
-
E
V
M
A
T
Y
L
L
L
G
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
70.69
46%
-106
- C2 -
-
5ES1
7.9
-
MARK4_HUMAN
A:
[12-328]
----------------------------------
P
H
V
G
N
Y
R
L
L
R
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
----
R
E
V
A
I
K
I
--
I
D
K
T
--
Q
-
L
-
N
-----
P
S
----
S
-
L
---
Q
K
L
F
---
R
E
V
R
I
M
K
G
L
N
-
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
A
G
E
V
F
D
Y
L
V
S
H
G
R
M
K
E
---
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
H
Y
C
H
Q
K
N
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
E
---
A
----
N
---
I
K
I
A
D
F
G
F
-
S
-
N
-----------------------
S
P
P
Y
A
A
P
E
L
F
--
Q
G
K
K
Y
D
-----
G
P
E
-----
V
D
I
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
--
G
--
H
N
L
K
-----
E
L
R
E
R
V
L
--
R
G
--
K
--
Y
R
---
V
--
P
----
F
-
Y
--
M
S
-------
T
D
-------
C
E
S
I
----
L
R
R
F
L
V
L
N
P
A
K
R
C
-----
T
L
E
Q
I
M
K
D
K
------
W
---
I
--------
N
I
G
Y
EG
E
E
L
K
---
P
Y
T
E
P
E
E
D
F
G
---------------
D
T
K
R
I
E
V
M
V
G
-
M
G
--
Y
T
R
E
E
I
K
E
S
L
T
S
Q
K
Y
N
-
E
V
T
A
T
Y
L
L
L
G
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
70.49
46%
-119
- C2 -
-
1ZMV
-
-
MARK2_RAT
A:
[51-363]
-------------------------------------
G
N
Y
R
L
L
K
T
I
G
K
G
--
A
K
V
K
L
A
R
H
I
L
T
G
----
K
E
V
A
V
R
I
--
I
D
K
T
--
Q
-
L
-
N
-----
S
S
----
S
-
L
---
Q
K
L
F
---
R
E
V
R
I
M
K
V
L
N
-
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
---
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
D
---
M
----
N
---
I
K
I
A
------------------------------
G
S
P
P
Y
A
A
P
E
L
F
--
Q
G
K
K
Y
D
-----
G
P
E
-----
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
--
G
--
Q
N
L
K
-----
E
L
R
E
R
V
L
--
R
G
--
K
--
Y
R
---
I
--
P
----
F
-
Y
--
M
S
-------
T
D
-------
C
E
N
L
----
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
R
------
W
---
M
--------
N
V
G
---
H
E
D
D
ELK
P
Y
V
E
P
L
P
D
Y
K
---------------
D
P
R
R
T
E
L
M
V
S
-
M
G
Y
--
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
-
E
V
M
A
T
Y
L
L
L
G
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
579
HHSearch
69.86
44%
-114
- C- -
-
3FE3
-
-
MARK3_HUMAN
B:
[50-365]
---------------------------------
Q
P
H
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
----
R
E
V
A
I
K
I
--
I
D
K
T
--
Q
-
L
-
N
-----
P
T
----
S
-
L
---
Q
K
L
F
---
R
E
V
R
I
M
K
I
L
N
-
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
I
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
---
K
E
A
R
S
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
R
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
D
---
M
----
N
---
I
K
I
A
D
F
G
F
-
S
-
N
-
E
---
F
T
-
V
--
G
-
G
K
-
L
D
A
F
-
C
G
A
P
P
Y
A
A
P
E
L
F
--
Q
G
K
K
Y
D
-----
G
P
E
-----
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
--
G
--
Q
N
L
K
-----
E
L
R
E
R
V
L
--
R
G
--
K
--
Y
R
---
I
--
P
----
F
-
Y
--
M
S
-------
T
D
-------
C
E
N
L
----
L
K
R
F
L
V
L
N
P
I
K
R
G
-----
T
L
E
Q
I
M
K
D
R
------
W
---
I
--------
N
A
G
H
--
E
E
D
E
-----
L
K
--------
P
---
F
V
E
P
E
L
D
I
S
D
Q
K
R
I
D
I
M
V
G
-
M
G
Y
S
--
Q
E
E
I
Q
E
S
L
S
K
M
K
Y
D
E
I
T
A
T
Y
L
L
L
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
69.75
46%
-109
- C2 -
-
1ZMU
-
-
MARK2_RAT
A:
[51-363]
-------------------------------------
G
N
Y
R
L
L
K
T
I
G
K
G
--
A
K
V
K
L
A
R
H
I
L
T
G
----
K
E
V
A
V
K
I
--
I
D
K
T
--
Q
-
L
-
N
-----
S
S
----
S
-
L
---
Q
K
L
F
---
R
E
V
R
I
M
K
V
L
N
-
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
---
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
D
---
M
----
N
---
I
K
I
A
------------------------------
G
S
P
P
Y
A
A
P
E
L
F
--
Q
G
K
K
Y
D
-----
G
P
E
-----
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
--
G
--
Q
N
L
K
-----
E
L
R
E
R
V
L
--
R
G
--
K
--
Y
R
---
I
--
P
----
F
-
Y
--
M
S
-------
T
D
-------
C
E
N
L
----
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
R
------
W
---
M
--------
N
V
G
---
H
E
D
D
ELK
P
Y
V
E
P
L
P
D
Y
K
---------------
D
P
R
R
T
E
L
M
V
S
-
M
G
Y
--
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
-
E
V
M
A
T
Y
L
L
L
G
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
69.24
50%
-120
- C2 -
-
2QNJ
-
-
MARK3_HUMAN
A:
[52-322]
-----------------------------------
H
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
----
R
E
V
A
I
K
I
--
I
D
K
T
--
Q
-
L
-
N
-----
P
T
----
S
-
L
---
Q
K
L
F
---
R
E
V
R
I
M
K
I
L
N
-
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
I
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
---
K
E
A
R
S
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
R
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
D
---
M
----
N
---
I
K
I
A
D
F
G
F
-
S
-
N
-
E
---
F
T
----------
D
T
F
-
C
G
S
P
P
Y
A
A
P
E
L
F
--
Q
G
K
K
Y
D
-----
G
P
E
-----
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
--
G
--
Q
N
L
K
-----
E
L
R
E
R
V
L
--
R
G
--
K
--
Y
R
---
I
--
P
----
F
-
Y
--
M
S
-------
T
D
-------
C
E
N
L
----
L
K
R
F
L
V
L
N
P
I
K
R
G
-----
T
L
E
Q
I
M
K
D
R
------
W
---
I
--------
N
A
G
---
H
E
E
D
ELK
P
F
V
E
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
69.11
46%
-113
- C- -
-
2R0I
-
-
MARK2_RAT
A:
[49-363]
-----------------------------------
H
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
----
K
E
V
A
V
K
I
--
I
D
K
T
--
Q
-
L
-
N
-----
S
S
----
S
-
L
---
Q
K
L
F
---
R
E
V
R
I
M
K
V
L
N
-
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
---
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
D
---
M
----
N
---
I
K
I
A
D
F
----------------------------
G
S
P
P
Y
A
A
P
E
L
F
--
Q
G
K
K
Y
D
-----
G
P
E
-----
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
--
G
--
Q
N
L
K
-----
E
L
R
E
R
V
L
--
R
G
--
K
--
Y
R
---
I
--
P
----
F
-
Y
--
M
S
-------
T
D
-------
C
E
N
L
----
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
R
------
W
---
M
--------
N
V
G
---
H
E
D
D
ELK
P
Y
V
A
P
L
P
D
Y
K
---------------
D
P
R
R
T
E
L
M
V
S
-
M
G
Y
--
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
-
E
V
M
A
T
Y
L
L
L
G
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
Blastp_CBE
68.30
42%
-155
- C2 -
-
4UMQ
5.8
-
MELK_HUMAN
A:
[25-290]
---------------------------------
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
----
E
M
V
A
I
K
I
--
M
D
K
N
--
T
-
L
-
G
------
S
----
D
-
L
---
P
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
-------------------------
C
G
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
S
Y
L
-----
G
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
--
D
--
D
T
A
A
-----
A
L
V
A
K
I
M
--
R
G
--
K
--
Y
D
---
V
--
P
----
K
-
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
------
W
---
I
--------
M
Q
D
Y
--
N
Y
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
Blastp_CBE
68.23
42%
-160
- C2 -
-
4UMR
5.3
-
MELK_HUMAN
A:
[26-290]
----------------------------------
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
----
E
M
V
A
I
K
I
--
M
D
K
N
--
T
-
L
-
G
------
S
----
D
-
L
---
P
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
-------------------------
C
G
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
S
Y
L
-----
G
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
--
D
--
D
T
A
A
-----
A
L
V
A
K
I
M
--
R
G
--
K
--
Y
D
---
V
--
P
----
K
-
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
------
W
---
I
--------
M
Q
D
Y
--
N
Y
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
Blastp_CBE
68.21
42%
-153
- C2 -
-
4UMT
9.5
-
MELK_HUMAN
A:
[23-290]
-----------------------------
D
Y
--
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
----
E
M
V
A
I
K
I
--
M
D
K
N
--
T
-
L
-
G
------
S
----
D
-
L
---
P
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
-------------------------
C
G
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
S
Y
L
-----
G
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
--
D
--
D
T
A
A
-----
A
L
V
A
K
I
M
--
R
G
--
K
--
Y
D
---
V
--
P
----
K
-
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
------
W
---
I
--------
M
Q
D
Y
--
N
Y
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
Blastp_CBE
68.06
41%
-146
- C2 -
-
4D2T
-
-
MELK_HUMAN
A:
[21-290]
-----------------------
M
K
----
D
Y
--
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
----
E
M
V
A
I
K
I
--
M
D
K
N
--
T
---------------
D
-
L
---
P
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
-
C
--------------------
A
C
-
C
G
A
L
A
Y
A
A
P
E
L
I
--
Q
G
K
S
-------
G
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
--
D
--
D
T
A
A
-----
A
L
V
A
K
I
M
--
R
G
--
K
--
Y
D
---
V
--
P
----
K
-
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
------
W
---
I
--------
M
Q
D
Y
--
N
Y
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
Blastp_CBE
67.56
42%
-149
- C2 -
-
4UMU
9.1
-
MELK_HUMAN
A:
[23-290]
-----------------------------
D
Y
--
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
----
E
M
V
A
I
K
I
--
M
D
K
N
--
T
-
L
-
G
------
S
----
D
-
L
---
P
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
-------------------------
C
G
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
S
Y
L
-----
G
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
--
D
--
D
T
A
A
-----
A
L
V
A
K
I
M
--
R
G
--
K
--
Y
D
---
V
--
P
----
K
-
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
------
W
---
I
--------
M
Q
D
Y
--
N
Y
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
Blastp_CBE
66.99
44%
-142
- C2 -
-
5TVT
8.1
-
MELK_HUMAN
A:
[12-271]
---------------------------------------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
----
E
M
V
A
I
K
I
--
M
D
K
N
--
T
-
L
-
G
------
S
----
D
-
L
---
P
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
-
C
-
A
-
K
--------------------
G
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
S
Y
L
-----
G
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
--
D
--
D
N
V
M
-----
A
L
Y
K
K
I
M
--
R
G
--
K
--
Y
D
---
V
--
P
----
K
-
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
------
W
---
I
--------
M
Q
D
Y
--
N
Y
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
Blastp_CBE
66.87
42%
-148
- C2 -
-
4BKY
7.0
-
MELK_HUMAN
A:
[4-271]
-----------------------------
D
Y
--
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
----
E
M
V
A
I
K
I
--
M
D
K
N
--
T
-
L
-------------
D
-
L
---
P
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
-
C
-
A
-----------------------
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
--------
G
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
--
D
--
D
N
V
M
-----
A
L
Y
K
K
I
M
--
R
G
--
K
--
Y
D
---
V
--
P
----
K
-
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
------
W
---
I
--------
M
Q
D
Y
--
N
Y
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
584
HHSearch
66.86
43%
-145
- C2 -
-
5TVT
8.1
-
MELK_HUMAN
A:
[5-268]
------------------------------
Y
--
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
----
E
M
V
A
I
K
I
--
M
D
K
N
--
T
-
L
-
G
------
S
----
D
-
L
---
P
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
-
C
-
A
-
K
--------------------
G
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
S
Y
L
-----
G
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
--
D
--
D
N
V
M
-----
A
L
Y
K
K
I
M
--
R
G
--
K
--
Y
D
---
V
--
P
----
K
-
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
------
W
---
I
--------
M
Q
D
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
Blastp_CBE
66.74
44%
-157
- C2 -
-
5IHC
5.8
-
MELK_HUMAN
A:
[10-269]
---------------------------------------
Y
E
L
H
E
T
I
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
----
E
M
V
A
I
K
I
--
M
D
K
N
--
T
-
L
-
G
------
S
----
D
-
L
---
P
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
----------------------------
G
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
S
Y
L
-----
G
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
--
D
--
D
N
V
M
-----
A
L
Y
K
K
I
M
--
R
G
--
K
--
Y
D
---
V
--
P
----
K
-
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
------
W
---
I
--------
M
Q
D
Y
--
N
Y
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
Blastp_CBE
66.65
44%
-144
- C2 -
-
5TWL
7.3
-
MELK_HUMAN
A:
[12-271]
---------------------------------------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
----
E
M
V
A
I
K
I
--
M
D
K
N
--
T
-
L
-
G
------
S
----
D
-
L
---
P
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
-------------------------
C
G
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
S
Y
L
-----
G
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
--
D
--
D
N
V
M
-----
A
L
Y
K
K
I
M
--
R
G
--
K
--
Y
D
---
V
--
P
----
K
-
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
------
W
---
I
--------
M
Q
D
Y
--
N
Y
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
Blastp_CBE
66.63
42%
-149
- C2 -
-
5MAI
7.1
-
MELK_HUMAN
A:
[2-273]
-----------------------
P
K
----
D
Y
--
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
----
E
M
V
A
I
K
I
--
M
D
K
N
--
T
-
L
-
G
------
S
----
D
-
L
---
P
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
-----------------------------
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
S
Y
L
-----
G
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
--
D
--
D
N
V
M
-----
A
L
Y
K
K
I
M
--
R
G
--
K
--
Y
D
---
V
--
P
----
K
-
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
------
W
---
I
--------
M
Q
D
Y
--
N
Y
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
Blastp_CBE
66.59
42%
-148
- C2 -
-
5MAG
5.9
-
MELK_HUMAN
A:
[4-271]
-----------------------------
D
Y
--
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
-
A
K
V
K
L
A
C
H
I
L
T
G
----
E
M
V
A
I
K
I
--
M
D
K
N
--
T
-
L
-------------
D
-
L
---
P
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
-
C
-
A
-
K
---------------------
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
--
L
-----
G
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
--
D
--
D
N
V
M
-----
A
L
Y
K
K
I
M
--
R
G
--
K
--
Y
D
---
V
--
P
----
K
-
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
------
W
---
I
--------
M
Q
D
Y
--
N
Y
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
Blastp_CBE
66.54
44%
-156
- C2 -
-
5TWZ
4.9
-
MELK_HUMAN
A:
[12-271]
---------------------------------------
Y
E
L
H
E
T
I
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
----
E
M
V
A
I
K
I
--
M
D
K
N
--
T
-
L
-
G
------
S
----
D
-
L
---
P
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
---------------------------
G
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
S
Y
L
-----
G
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
--
D
--
D
N
V
M
-----
A
L
Y
K
K
I
M
--
R
G
--
K
--
Y
D
---
V
--
P
----
K
-
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
------
W
---
I
--------
M
Q
D
Y
--
N
Y
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
Blastp_CBE
66.29
42%
-146
- C2 -
-
5MAH
5.8
-
MELK_HUMAN
A:
[3-271]
------------------------
K
----
D
Y
--
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
----
E
M
V
A
I
K
I
--
M
D
K
N
--
T
-
L
-
G
------
S
----
D
-
L
---
P
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
-
C
-
A
-
K
---------------------
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
--
L
-----
G
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
--
D
--
D
N
V
M
-----
A
L
Y
K
K
I
M
--
R
G
--
K
--
Y
D
---
V
--
P
----
K
-
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
------
W
---
I
--------
M
Q
D
Y
--
N
Y
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
Blastp_CBE
66.11
44%
-142
- C2 -
-
5K00
11.7
-
MELK_HUMAN
A:
[10-269]
---------------------------------------
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
----
E
M
V
A
I
K
I
--
M
D
K
N
--
T
-
L
-
G
------
S
----
D
-
L
---
P
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
-
C
-
A
-
K
---
P
-----------------
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
S
Y
L
-----
G
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
--
D
--
D
N
V
M
-----
A
L
Y
K
K
I
M
--
R
G
--
K
--
Y
D
---
V
--
P
----
K
-
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
------
W
---
I
--------
M
Q
D
Y
--
N
Y
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
Blastp_CBE
65.75
42%
-141
- C2 -
-
5MAF
6.8
-
MELK_HUMAN
A:
[2-271]
-----------------------
P
K
----
D
Y
--
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
----
E
M
V
A
I
K
I
--
M
D
K
N
--
T
-
L
-------------
D
-
L
---
P
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
-
C
-
A
-
K
---------------------
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
--
L
-----
G
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
--
D
--
D
N
V
M
-----
A
L
Y
K
K
I
M
--
R
G
--
K
--
Y
D
---
V
--
P
----
K
-
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
------
W
---
I
--------
M
Q
D
Y
--
N
Y
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
583
HHSearch
65.72
43%
-145
* C2 *
-
5K00
11.7
-
MELK_HUMAN
A:
[5-266]
----------------------------------
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
----
E
M
V
A
I
K
I
--
M
D
K
N
--
T
-
L
-
G
------
S
----
D
-
L
---
P
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
-
C
-
A
-
K
---
P
-----------------
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
S
Y
L
-----
G
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
--
D
--
D
N
V
M
-----
A
L
Y
K
K
I
M
--
R
G
--
K
--
Y
D
---
V
--
P
----
K
-
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
------
W
---
I
--------
M
Q
D
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
Blastp_CBE
65.67
44%
-156
- C2 -
-
5TWY
5.8
-
MELK_HUMAN
A:
[12-271]
---------------------------------------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
----
E
M
V
A
I
K
I
--
M
D
K
N
--
T
---------------
D
-
L
---
P
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
-------------------------
C
G
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
--------
G
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
--
D
--
D
N
V
M
-----
A
L
Y
K
K
I
M
--
R
G
--
K
--
Y
D
---
V
--
P
----
K
-
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
------
W
---
I
--------
M
Q
D
Y
--
N
Y
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
Blastp_CBE
65.62
42%
-154
- C2 -
-
4BKZ
4.9
-
MELK_HUMAN
A:
[3-271]
------------------------
K
----
D
Y
--
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
----
E
M
V
A
I
K
I
--
M
D
K
N
--
T
-
L
---------------
L
---
P
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
-
C
-
A
-----------------------
S
L
A
Y
A
A
P
E
L
I
--
Q
G
---------
G
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
--
D
--
D
N
V
M
-----
A
L
Y
K
K
I
M
--
R
G
--
K
--
Y
D
---
V
--
P
----
K
-
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
------
W
---
I
--------
M
Q
D
Y
--
N
Y
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
Blastp_CBE
65.58
44%
-151
- C2 -
-
4CQG
9.0
-
MELK_MOUSE
A:
[11-264]
---------------------------------------
Y
E
L
Y
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
V
L
T
G
----
E
M
V
A
I
K
I
--
M
D
K
N
--
A
-
L
-
G
------
S
----
D
-
L
---
P
R
V
K
---
T
E
I
D
A
L
K
S
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
K
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
L
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
N
---
H
----
K
---
L
K
L
I
D
F
G
L
-
C
-
A
-
K
-------------------
C
G
S
L
A
Y
A
A
P
E
L
I
--
Q
----------
G
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
--
D
--
D
N
V
M
-----
A
L
Y
K
K
I
M
--
R
G
--
K
--
Y
E
---
V
--
P
----
K
-
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
R
N
L
L
N
H
P
------
W
---
V
--------
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
Blastp_CBE
65.53
44%
-149
- C2 -
-
4BFM
5.9
-
MELK_MOUSE
A:
[11-264]
---------------------------------------
Y
E
L
Y
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
V
L
T
G
----
E
M
V
A
I
K
I
--
M
D
K
N
--
A
-
L
-
G
------
S
----
D
-
L
---
P
R
V
K
---
T
E
I
D
A
L
K
S
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
K
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
L
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
N
---
H
----
K
---
L
K
L
I
D
F
G
L
-
C
-
A
-
K
-------------------
C
G
S
L
A
Y
A
A
P
E
L
I
--
Q
----------
G
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
--
D
--
D
N
V
M
-----
A
L
Y
K
K
I
M
--
R
G
--
K
--
Y
E
---
V
--
P
----
K
-
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
R
N
L
L
N
H
P
------
W
---
V
--------
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
Blastp_CBE
65.49
42%
-145
- C2 -
-
5M5A
8.2
-
MELK_HUMAN
A:
[3-271]
------------------------
K
----
D
Y
--
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
----
E
M
V
A
I
K
I
--
M
D
K
N
--
T
-
L
-
G
------
S
----
D
-
L
---
P
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
-
C
-
A
-----------------------
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
--
L
-----
G
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
--
D
--
D
N
V
M
-----
A
L
Y
K
K
I
M
--
R
G
--
K
--
Y
D
---
V
--
P
----
K
-
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
------
W
---
I
--------
M
Q
D
Y
--
N
Y
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
Blastp_CBE
65.41
44%
-151
- C2 -
-
5IH8
5.7
-
MELK_HUMAN
A:
[10-269]
---------------------------------------
Y
E
L
H
E
T
I
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
----
E
M
V
A
I
K
I
--
M
D
K
N
--
T
---------------
D
-
L
---
P
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
-
C
-
A
-
K
---------------------
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
S
Y
L
-----
G
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
--
D
--
D
N
V
M
-----
A
L
Y
K
K
I
M
--
R
G
--
K
--
Y
D
---
V
--
P
----
K
-
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
------
W
---
I
--------
M
Q
D
Y
--
N
Y
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
Blastp_CBE
65.24
44%
-150
- C2 -
-
5IHA
6.2
-
MELK_HUMAN
A:
[10-269]
---------------------------------------
Y
E
L
H
E
T
I
G
----
A
K
V
K
L
A
C
H
I
L
T
G
----
E
M
V
A
I
K
I
--
M
D
K
N
--
T
-
L
--------------------
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
-
C
-
A
-
K
---------------------
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
S
Y
L
-----
G
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
--
D
--
D
N
V
M
-----
A
L
Y
K
K
I
M
--
R
G
--
K
--
Y
D
---
V
--
P
----
K
-
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
------
W
---
I
--------
M
Q
D
Y
--
N
Y
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
65.05
42%
-46
- C2 -
-
6B2E
7.5
-
AAPK2_HUMAN
A:
[26-439]
------------------------------------
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
----
H
K
V
A
V
K
I
--
L
N
R
Q
--
K
-
I
R
S
-----
L
D
----
V
-
V
---
G
K
I
K
---
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
---
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
H
---
M
----
N
---
A
K
I
A
D
F
G
L
-
S
-
N
-
M
---
M
S
-
D
--
G
-
E
F
-
L
R
T
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
G
R
L
Y
A
-----
G
P
E
-----
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
--
D
--
E
H
V
P
-----
T
L
F
K
K
I
R
--
G
G
--
V
--
F
Y
---
I
--
P
----
E
-
Y
--
L
N
-------
R
S
-------
V
A
T
L
----
L
M
H
M
L
Q
V
D
P
L
K
R
A
-----
T
I
K
D
I
R
E
H
E
------
W
---
F
--------
K
Q
G
L
----
P
S
---
Y
L
F
P
E
D
P
----------
S
Y
D
A
N
V
I
D
D
E
A
V
K
E
V
C
E
K
-
F
E
C
-
T
E
S
E
V
M
N
S
L
Y
S
G
D
P
Q
-----
A
Y
H
L
I
I
D
N
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
Blastp_CBE
64.99
44%
-162
- C2 -
-
5TX3
6.7
-
MELK_HUMAN
A:
[15-274]
---------------------------------------
Y
E
L
H
E
T
I
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
----
E
M
V
A
I
K
I
--
M
D
K
N
--------------------------
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
--------------------------
G
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
--------
G
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
--
D
--
D
N
V
M
-----
A
L
Y
K
K
I
M
--
R
G
--
K
--
Y
D
---
V
--
P
----
K
-
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
------
W
---
I
--------
M
Q
D
Y
--
N
Y
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
Blastp_CBE
64.97
44%
-139
- C2 -
-
6GVX
6.4
-
MELK_HUMAN
B:
[15-274]
---------------------------------------
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
----
E
M
V
A
I
K
I
--
M
D
K
N
--
T
----------
S
----
D
-
L
---
P
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
-
C
-
A
-
K
---
P
----------------
G
S
L
A
Y
A
A
P
E
L
I
--
Q
G
---------
G
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
--
D
--
D
N
V
M
-----
A
L
Y
K
K
I
M
--
R
G
--
K
--
Y
D
---
V
--
P
----
K
-
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
------
W
---
I
--------
M
Q
D
Y
--
N
Y
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
Blastp_CBE
64.78
42%
-145
- C2 -
-
4BL1
5.6
-
MELK_HUMAN
A:
[3-271]
------------------------
K
----
D
Y
--
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
----
E
M
V
A
I
K
I
--
M
D
K
N
--
T
-
L
---------------
L
---
P
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
-
C
-
A
-
K
---------------------
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
--------
G
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
--
D
--
D
N
V
M
-----
A
L
Y
K
K
I
M
--
R
G
--
K
--
Y
D
---
V
--
P
----
K
-
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
------
W
---
I
--------
M
Q
D
Y
--
N
Y
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
Blastp_CBE
64.35
44%
-143
- C2 -
-
5IH9
6.2
-
MELK_HUMAN
A:
[10-269]
---------------------------------------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
----
E
M
V
A
I
K
I
--
M
D
K
N
--
T
-----------------
L
---
P
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
-
C
-
A
-
K
---------------------
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
S
Y
L
-----
G
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
--
D
--
D
N
V
M
-----
A
L
Y
K
K
I
M
--
R
G
--
K
--
Y
D
---
V
--
P
----
K
-
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
------
W
---
I
--------
M
Q
D
Y
--
N
Y
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
Blastp_CBE
63.35
44%
-155
- C2 -
-
5TWY
5.8
-
MELK_HUMAN
B:
[12-271]
---------------------------------------
Y
E
L
H
E
T
I
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
----
E
M
V
A
I
K
I
--
M
D
K
N
------------------
D
-
L
---
P
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
-
C
--------------------------
L
A
Y
A
A
P
E
L
I
--
Q
G
K
--------
G
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
--
D
--
D
N
V
M
-----
A
L
Y
K
K
I
M
--
R
G
--
K
--
Y
D
---
V
--
P
----
K
-
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
------
W
---
I
--------
M
Q
D
Y
--
N
Y
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
Blastp_CBE
62.38
44%
-155
- C2 -
-
5TX3
7.2
-
MELK_HUMAN
B:
[15-274]
---------------------------------------
Y
E
L
H
E
T
I
G
-----
K
V
K
L
A
C
H
I
L
T
G
----
E
M
V
A
I
K
I
--
M
D
K
----------------------------
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
-----------------------------
G
S
L
A
Y
A
A
P
E
L
I
--
Q
G
---
L
-----
G
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
--
D
--
D
N
V
M
-----
A
L
Y
K
K
I
M
--
R
G
--
K
--
Y
D
---
V
--
P
----
K
-
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
------
W
---
I
--------
M
Q
D
Y
--
N
Y
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
146
Blastp_CBE
62.33
36%
-80
- C2 -
-
3BHH
5.6
-
KCC2B_HUMAN
A:
[6-290]
---------------------------------------
Y
Q
L
Y
E
D
I
G
----
S
V
V
R
R
C
V
K
L
C
T
G
----
H
E
Y
A
A
K
I
--
I
N
T
K
--
K
-
L
-
S
-----
A
R
----
D
-
H
---
Q
K
L
E
---
R
E
A
R
I
C
R
L
L
K
-
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
---
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
K
---
C
----
K
GAA
V
K
L
A
D
F
G
L
-
A
-
I
-
E
---
V
Q
-
G
--
D
-
Q
Q
-
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
--
R
K
E
A
Y
------
G
K
P
-----
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
--
D
--
E
D
Q
H
-----
K
L
Y
Q
Q
I
K
--
A
G
--
A
--
Y
D
---
F
--
P
SPEW
D
-
T
--
V
T
-------
P
E
-------
A
K
N
L
----
I
N
Q
M
L
T
I
N
P
A
K
R
I
-----
T
A
H
E
A
L
K
H
P
------
W
---
V
CQRSTVAS
M
M
H
R
--
Q
E
T
V
---
E
C
L
K
K
F
N
A
R
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
145
Blastp_CBE
62.23
36%
-83
- C2 -
-
3BHH
5.9
-
KCC2B_HUMAN
B:
[6-290]
---------------------------------------
Y
Q
L
Y
E
D
I
G
K
---
S
V
V
R
R
C
V
K
L
C
T
G
----
H
E
Y
A
A
K
I
--
I
N
T
K
--
K
-
L
-
S
-----
A
R
----
D
-
H
---
Q
K
L
E
---
R
E
A
R
I
C
R
L
L
K
-
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
---
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
K
---
C
----
K
GAA
V
K
L
A
D
F
G
L
-
A
-
I
-
E
---
V
Q
-
G
--
D
-
Q
Q
-
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
--
R
K
E
A
Y
------
G
K
P
-----
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
--
D
--
E
D
Q
H
-----
K
L
Y
Q
Q
I
K
--
A
G
--
A
--
Y
D
---
F
--
P
SPEW
D
-
T
--
V
T
-------
P
E
-------
A
K
N
L
----
I
N
Q
M
L
T
I
N
P
A
K
R
I
-----
T
A
H
E
A
L
K
H
P
------
W
---
V
CQRSTVAS
M
M
H
R
--
Q
E
T
V
---
E
C
L
K
K
F
N
A
R
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
122
Blastp_CBE
62.20
36%
-69
- C2 -
-
6AYW
5.9
-
KCC2D_HUMAN
B:
[10-299]
----------------------------------
R
F
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
----
Q
E
Y
A
A
K
I
--
I
N
T
K
--
K
-
L
-
S
-----
A
R
----
D
-
H
---
Q
K
L
E
---
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
---
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
K
---
S
----
K
GAA
V
K
L
A
D
F
G
L
-
A
-
I
-
E
---
V
Q
-
G
--
D
-
Q
Q
-
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
--
R
K
D
P
Y
------
G
K
P
-----
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
--
D
--
E
D
Q
H
-----
R
L
Y
Q
Q
I
K
--
A
G
--
A
--
Y
D
---
F
--
P
SPEW
D
-
T
--
V
T
-------
P
E
-------
A
K
D
L
----
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
L
K
H
P
------
W
---
I
CQRSTVAS
M
M
H
R
--
Q
E
T
V
---
D
C
L
K
K
F
N
A
R
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
202
Blastp_CBE
61.09
34%
-73
- C2 -
-
3SOA
3.3
-
KCC2A_HUMAN
A:
[8-297]
----------------------------------
R
F
T
E
E
Y
Q
L
F
E
E
L
G
K
G
--
S
V
V
R
R
C
V
K
V
L
A
G
----
Q
E
Y
A
A
M
I
--
I
N
T
K
--
K
-
L
-
S
-----
A
R
----
D
-
H
---
Q
K
L
E
---
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
H
H
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
---
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
N
L
K
P
E
N
L
L
---
L
---
A
S
K
LKG
A
----
A
---
V
K
L
A
D
F
G
L
-
A
-
I
-
E
---
V
E
-
G
--
E
-
Q
Q
-
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
--
R
K
D
P
Y
------
G
K
P
-----
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
--
D
--
E
D
Q
H
-----
R
L
Y
Q
Q
I
K
--
A
G
--
A
--
Y
D
---
F
--
P
SPEW
D
-
T
--
V
T
-------
P
E
-------
A
K
D
L
----
I
N
K
M
L
T
I
N
P
S
K
R
I
-----
T
A
A
E
A
L
K
H
P
------
W
---
I
SHRSTVAS
C
M
H
R
--
Q
E
T
V
---
D
C
L
K
K
F
N
A
R
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
124
Blastp_CBE
61.07
36%
-68
- C2 -
-
5VLO
7.7
-
KCC2D_HUMAN
B:
[10-299]
----------------------------------
R
F
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
----
Q
E
Y
A
A
K
I
--
I
N
T
K
--
K
-
L
-
S
-----
A
R
----
D
-
H
---
Q
K
L
E
---
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
---
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
K
---
S
----
K
GAA
V
K
L
A
D
F
G
L
-
A
-
I
-
E
---
V
Q
-
G
--
D
-
Q
Q
-
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
--
R
K
D
P
Y
------
G
K
P
-----
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
--
D
--
E
D
Q
H
-----
R
L
Y
Q
Q
I
K
--
A
G
--
A
--
Y
D
---
F
--
P
SPEW
D
-
T
--
V
T
-------
P
E
-------
A
K
D
L
----
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
L
K
H
P
------
W
---
I
CQRSTVAS
M
M
H
R
--
Q
E
T
V
---
D
C
L
K
K
F
N
A
R
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
125
Blastp_CBE
61.06
36%
-72
- C2 -
-
5VLO
7.0
-
KCC2D_HUMAN
A:
[10-299]
----------------------------------
R
F
T
D
E
Y
Q
L
F
E
E
L
G
---
F
S
V
V
R
R
C
M
K
I
P
T
G
----
Q
E
Y
A
A
K
I
--
I
N
T
K
--
K
-
L
-
S
-----
A
R
----
D
-
H
---
Q
K
L
E
---
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
---
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
K
---
S
----
K
GAA
V
K
L
A
D
F
G
L
-
A
-
I
-
E
---
V
Q
-
G
--
D
-
Q
Q
-
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
--
R
K
D
P
Y
------
G
K
P
-----
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
--
D
--
E
D
Q
H
-----
R
L
Y
Q
Q
I
K
--
A
G
--
A
--
Y
D
---
F
--
P
SPEW
D
-
T
--
V
T
-------
P
E
-------
A
K
D
L
----
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
L
K
H
P
------
W
---
I
CQRSTVAS
M
M
H
R
--
Q
E
T
V
---
D
C
L
K
K
F
N
A
R
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
128
Blastp_CBE
61.04
37%
-81
- C2 -
-
2WEL
5.2
-
KCC2D_HUMAN
A:
[6-290]
---------------------------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
----
Q
E
Y
A
A
K
I
--
I
N
T
K
--
K
-
L
-
S
-----
A
R
----
D
-
H
---
Q
K
L
E
---
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
---
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
K
---
S
----
K
GAA
V
K
L
A
D
F
G
L
-
A
-
I
-
E
---
V
Q
-
G
--
D
-
Q
Q
-
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
--
R
K
D
P
Y
------
G
K
P
-----
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
--
D
--
E
D
Q
H
-----
R
L
Y
Q
Q
I
K
--
A
G
--
A
--
Y
D
---
F
--
P
SPEW
D
-
T
--
V
T
-------
P
E
-------
A
K
D
L
----
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
L
K
H
P
------
W
---
I
CQRS----
M
M
H
R
--
Q
E
T
V
---
D
C
L
K
K
F
N
A
R
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
123
Blastp_CBE
60.93
36%
-71
- C2 -
-
6AYW
5.8
-
KCC2D_HUMAN
A:
[10-299]
----------------------------------
R
F
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
----
Q
E
Y
A
A
K
I
--
I
N
T
K
--
K
-
L
-
S
-----
A
R
----
D
-
H
---
Q
K
L
E
---
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
---
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
K
---
S
----
K
GAA
V
K
L
A
D
F
G
L
-
A
-
I
-
E
---
V
Q
-
G
--
D
-
Q
Q
-
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
--
R
K
D
P
Y
------
G
K
P
-----
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
--
D
--
E
D
Q
H
-----
R
L
Y
Q
Q
I
K
--
A
G
--
A
--
Y
D
---
F
--
P
SPEW
D
-
T
--
V
T
-------
P
E
-------
A
K
D
L
----
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
L
K
H
P
------
W
---
I
CQRSTVAS
M
M
H
R
--
Q
E
T
V
---
D
C
L
K
K
F
N
A
R
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
120
Blastp_CBE
60.47
36%
-67
- C2 -
-
6BAB
6.5
-
KCC2D_MOUSE
B:
[14-299]
--------------------------------------
E
Y
Q
L
F
E
E
L
G
----
S
V
V
R
R
C
M
K
I
P
T
G
----
Q
E
Y
A
A
K
I
--
I
N
T
K
--
K
-
L
-
S
-----
A
R
----
D
-
H
---
Q
K
L
E
---
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
---
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
K
---
S
----
K
GAA
V
K
L
A
D
F
G
L
-
A
-
I
-
E
---
V
Q
-
G
--
D
-
Q
Q
-
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
--
R
K
D
P
Y
------
G
K
P
-----
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
--
D
--
E
D
Q
H
-----
R
L
Y
Q
Q
I
K
--
A
G
--
A
--
Y
D
---
F
--
P
SPEW
D
-
T
--
V
T
-------
P
E
-------
A
K
D
L
----
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
L
K
H
P
------
W
---
I
CQRSTVAS
M
M
H
R
--
Q
E
T
V
---
D
C
L
K
K
F
N
A
R
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
Blastp_CBE
60.47
44%
-88
- C2 -
-
6GVX
3.3
-
MELK_HUMAN
A:
[15-281]
---------------------------------------
Y
E
L
H
E
T
I
G
T
--
F
A
K
V
K
L
A
C
H
I
L
T
G
----
E
M
V
A
I
K
I
--
M
D
K
N
--
T
---------------
D
-
L
---
P
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
-
C
-
A
-
K
---
P
K
-
G
NK----------
C
G
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
--------
G
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
--
D
--
D
N
V
M
-----
A
L
Y
K
K
I
M
--
R
G
--
K
--
Y
D
---
V
--
P
----
K
-
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
------
W
---
I
--------
M
Q
D
Y
--
N
Y
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134
Blastp_CBE
60.13
37%
-66
- C2 -
-
2VN9
6.4
-
KCC2D_HUMAN
B:
[6-290]
---------------------------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
----
Q
E
Y
A
A
K
I
--
I
N
T
K
--
K
-
L
-
S
-----
A
R
----
D
-
H
---
Q
K
L
E
---
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
---
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
K
---
S
----
K
GAA
V
K
L
A
D
F
G
L
-
A
-
I
-
E
---
V
Q
-
G
--
D
-
Q
Q
-
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
--
R
K
D
P
Y
------
G
K
P
-----
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
--
D
--
E
D
Q
H
-----
R
L
Y
Q
Q
I
K
--
A
G
--
A
--
Y
D
---
F
--
P
SPEW
D
-
T
--
V
T
-------
P
E
-------
A
K
D
L
----
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
L
K
H
P
------
W
---
I
CQRSTVAS
M
M
H
R
--
Q
E
T
V
---
D
C
L
K
K
F
N
A
R
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
135
Blastp_CBE
60.01
37%
-67
- C2 -
-
2VN9
6.1
-
KCC2D_HUMAN
A:
[6-290]
---------------------------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
----
Q
E
Y
A
A
K
I
--
I
N
T
K
--
K
-
L
-
S
-----
A
R
----
D
-
H
---
Q
K
L
E
---
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
---
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
K
---
S
----
K
GAA
V
K
L
A
D
F
G
L
-
A
-
I
-
E
---
V
Q
-
G
--
D
-
Q
Q
-
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
--
R
K
D
P
Y
------
G
K
P
-----
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
--
D
--
E
D
Q
H
-----
R
L
Y
Q
Q
I
K
--
A
G
--
A
--
Y
D
---
F
--
P
SPEW
D
-
T
--
V
T
-------
P
E
-------
A
K
D
L
----
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
L
K
H
P
------
W
---
I
CQRSTVAS
M
M
H
R
--
Q
E
T
V
---
D
C
L
K
K
F
N
A
R
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
Blastp_CBE
59.97
50%
-47
- C2 -
-
6C9H
8.5
-
AAPK1_HUMAN
A:
[13-318]
------------------------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
----
H
K
V
A
V
K
I
--
L
N
R
Q
--
K
-
I
R
S
-----
L
D
----
V
-
V
---
G
K
I
R
---
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
---
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
H
---
M
----
N
---
A
K
I
A
D
F
G
L
-
S
-
N
-
M
---
M
S
-
D
--
G
-
E
F
-
L
R
T
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
G
R
L
Y
A
-----
G
P
E
-----
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
--
D
--
D
H
V
P
-----
T
L
F
K
K
I
C
--
D
G
--
I
--
F
Y
---
T
--
P
----
Q
-
Y
--
L
N
-------
P
S
-------
V
I
S
L
----
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
R
E
H
E
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
193
Blastp_CBE
59.76
35%
-67
- C2 -
-
2V7O
6.0
-
KCC2G_HUMAN
A:
[28-317]
----------------------------------
R
F
T
D
D
Y
Q
L
F
E
E
L
G
K
G
-
F
S
V
V
R
R
C
V
K
K
T
P
T
----
Q
E
Y
A
A
K
I
--
I
N
T
K
--
K
-
L
-
S
-----
A
R
----
D
-
H
---
Q
K
L
E
---
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
---
A
D
A
S
H
C
I
H
Q
I
L
E
S
V
N
H
I
H
Q
H
D
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
K
---
C
----
K
GAA
V
K
L
A
D
F
G
L
-
A
I
E
-
V
---
Q
G
-
E
--
Q
-
Q
A
-
W
F
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
--
R
K
D
P
Y
------
G
K
P
-----
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
--
D
--
E
D
Q
H
-----
K
L
Y
Q
Q
I
K
--
A
G
--
A
--
Y
D
---
F
--
P
SPEW
D
-
T
--
V
T
-------
P
E
-------
A
K
N
L
----
I
N
Q
M
L
T
I
N
P
A
K
R
I
-----
T
A
D
Q
A
L
K
H
P
------
W
---
V
CQRSTVAS
M
M
H
R
--
Q
E
T
V
---
E
C
L
R
K
F
N
A
R
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
127
Blastp_CBE
59.24
38%
-79
- C2 -
-
5FG8
4.6
-
KCC2A_DROME
A:
[9-273]
------------------------------
C
--
T
R
F
S
D
N
Y
D
I
K
E
E
L
G
K
G
A
F
S
I
V
K
R
C
V
Q
K
S
T
G
----
F
E
F
A
A
K
I
--
I
N
T
K
--
K
-
L
-
T
-----
A
R
----
D
-
F
---
Q
K
L
E
---
R
E
A
R
I
C
R
K
L
H
-
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
N
Y
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
F
Y
S
E
---
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
N
G
V
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
K
---
A
----
K
GAA
V
K
L
A
D
F
G
L
-
A
-
I
-
E
---
V
Q
-
G
--
D
H
Q
A
-
W
F
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
--
K
K
E
P
Y
------
G
K
S
-----
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
--
D
--
E
D
Q
H
-----
R
L
Y
S
Q
I
K
--
A
G
--
A
--
Y
D
---
Y
--
P
SPEW
D
-
T
--
V
T
-------
P
E
-------
A
K
N
L
----
I
N
Q
M
L
T
V
N
P
N
K
R
I
-----
T
A
A
E
A
L
K
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
121
Blastp_CBE
59.11
36%
-65
- C2 -
-
6BAB
7.5
-
KCC2D_MOUSE
A:
[12-299]
------------------------------------
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
----
Q
E
Y
A
A
K
I
--
I
N
T
K
--
K
-
L
-
S
-----
A
R
----
D
-
H
---
Q
K
L
E
---
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
---
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
K
---
S
----
K
GAA
V
K
L
A
D
F
G
L
-
A
-
I
-
E
---
V
Q
-
G
--
D
-
Q
Q
-
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
--
R
K
D
P
Y
------
G
K
P
-----
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
--
D
--
E
D
Q
H
-----
R
L
Y
Q
Q
I
K
--
A
G
--
A
--
Y
D
---
F
--
P
SPEW
D
-
T
--
V
T
-------
P
E
-------
A
K
D
L
----
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
L
K
H
P
------
W
---
I
CQRSTVAS
M
M
H
R
--
Q
E
T
V
---
D
C
L
K
K
F
N
A
R
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Blastp_CBE
59.04
50%
-57
- C2 -
-
3AQV
8.1
-
AAPK2_HUMAN
A:
[10-265]
------------------------------------
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
----
H
K
V
A
V
K
I
--
L
N
R
Q
--
K
-
I
R
S
-----
L
D
----
V
-
V
---
G
K
I
K
---
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
---
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
H
---
M
----
N
---
A
K
I
A
D
F
G
L
-
S
-
N
-
M
---
M
S
-
D
--
G
-
E
F
-
L
-------
P
N
Y
A
A
P
E
V
I
--
S
G
R
L
Y
A
-----
G
P
E
-----
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
--
D
--
E
H
V
P
-----
T
L
F
K
K
I
R
--
G
G
--
V
--
F
Y
---
I
--
P
----
E
-
Y
--
L
N
-------
R
S
-------
V
A
T
L
----
L
M
H
M
L
Q
V
D
P
L
K
R
A
-----
T
I
K
D
I
R
E
H
E
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
138
Blastp_CBE
58.83
37%
-79
- C2 -
-
5HU3
5.1
-
KCC2A_DROME
A:
[9-273]
------------------------------
C
--
T
R
F
S
D
N
Y
D
I
K
E
E
L
G
K
G
A
F
S
I
V
K
R
C
V
Q
K
S
T
G
----
F
E
F
A
A
K
I
--
I
N
T
K
--
K
-
L
-
T
-----
A
R
----
D
-
F
---
Q
K
L
E
---
R
E
A
R
I
C
R
K
L
H
-
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
N
Y
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
F
Y
S
E
---
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
N
G
V
V
H
R
N
L
K
P
E
N
L
L
---
L
---
A
S
K
---
A
----
K
GAA
V
K
L
A
D
F
G
L
-
A
-
I
-
E
---
V
Q
-
G
--
D
H
Q
A
-
W
F
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
--
K
K
E
P
Y
------
G
K
S
-----
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
--
D
--
E
D
Q
H
-----
R
L
Y
S
Q
I
K
--
A
G
--
A
--
Y
D
---
Y
--
P
SPEW
D
-
T
--
V
T
-------
P
E
-------
A
K
N
L
----
I
N
Q
M
L
T
V
N
P
N
K
R
I
-----
T
A
A
E
A
L
K
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
119
Blastp_CBE
58.82
36%
-66
- C2 -
-
6BAB
8.1
-
KCC2D_MOUSE
C:
[14-299]
--------------------------------------
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
--------
Q
E
Y
A
A
K
I
--
I
N
T
K
--
K
-
L
-
S
-----
A
R
----
D
-
H
---
Q
K
L
E
---
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
---
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
K
---
S
----
K
GAA
V
K
L
A
D
F
G
L
-
A
-
I
-
E
---
V
Q
-
G
--
D
-
Q
Q
-
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
--
R
K
D
P
Y
------
G
K
P
-----
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
--
D
--
E
D
Q
H
-----
R
L
Y
Q
Q
I
K
--
A
G
--
A
--
Y
D
---
F
--
P
SPEW
D
-
T
--
V
T
-------
P
E
-------
A
K
D
L
----
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
L
K
H
P
------
W
---
I
CQRSTVAS
M
M
H
R
--
Q
E
T
V
---
D
C
L
K
K
F
N
A
R
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
58.81
50%
-47
- C2 -
-
4REW
8.5
-
AAPK1_HUMAN
A:
[5-389]
------------------------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
----
H
K
V
A
V
K
I
--
L
N
R
Q
--
K
-
I
R
S
-----
L
D
----
V
-
V
---
G
K
I
R
---
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
---
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
H
---
M
----
N
---
A
K
I
A
D
F
G
L
-
S
-
N
-
M
---
M
S
-
D
--
G
-
E
F
-
L
R
T
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
G
R
L
Y
A
-----
G
P
E
-----
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
--
D
--
D
H
V
P
-----
T
L
F
K
K
I
C
--
D
G
--
I
--
F
Y
---
T
--
P
----
Q
-
Y
--
L
N
-------
P
S
-------
V
I
S
L
----
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
S
I
K
D
I
R
E
H
E
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
126
Blastp_CBE
58.43
38%
-75
- C2 -
-
5H9B
5.7
-
KCC2A_DROME
A:
[9-273]
------------------------------
C
--
T
R
F
S
D
N
Y
D
I
K
E
E
L
G
K
G
A
F
S
I
V
K
R
C
V
Q
K
S
T
G
----
F
E
F
A
A
K
I
--
I
N
T
K
--
K
-
L
-
T
-----
A
R
----
D
-
F
---
Q
K
L
E
---
R
E
A
R
I
C
R
K
L
H
-
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
N
Y
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
F
Y
S
E
---
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
N
G
V
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
K
---
A
----
K
GAA
V
K
L
A
D
F
G
L
-
A
-
I
-
E
---
V
Q
-
G
--
D
H
Q
A
-
W
F
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
--
K
K
E
P
Y
------
G
K
S
-----
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
--
D
--
E
D
Q
H
-----
R
L
Y
S
Q
I
K
--
A
G
--
A
--
Y
D
---
Y
--
P
SPEW
D
-
T
--
V
T
-------
P
E
-------
A
K
N
L
----
I
N
Q
M
L
T
V
N
P
N
K
R
I
-----
T
A
A
E
A
L
K
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129
Blastp_CBE
57.61
40%
-93
- C2 -
-
4FG7
4.3
-
KCC1A_HUMAN
A:
[20-277]
---------------------------------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
----
K
L
V
A
I
K
C
--
I
A
---------------------------
S
M
E
---
N
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
---
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
---
D
E
D
---
S
----
K
---
I
M
I
S
D
F
G
L
-
S
-
K
-
M
---
E
D
-
P
-------------
G
T
P
G
Y
V
A
P
E
V
L
--
A
Q
K
--------
S
K
A
-----
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
--
D
--
E
N
D
A
-----
K
L
F
E
Q
I
L
--
K
A
--
E
--
Y
E
---
F
DS
P
----
Y
-
W
DD
I
S
-------
D
S
-------
A
K
D
F
----
I
R
H
L
M
E
K
D
P
E
K
R
F
-----
T
C
E
Q
A
L
Q
H
P
------
W
---
I
--------
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Blastp_CBE
56.29
50%
-66
- C2 -
-
6BX6
5.2
-
AAPK2_HUMAN
A:
[10-265]
------------------------------------
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
----
H
K
V
A
V
K
I
--
L
N
R
Q
--
K
-
I
R
S
-----
L
D
----
V
-
V
---
G
K
I
K
---
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
---
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
H
---
M
----
N
---
A
K
I
A
D
F
G
L
-
S
---------------------------
N
Y
A
A
P
E
--------
Y
A
-----
G
P
E
-----
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
--
D
--
E
H
V
P
-----
T
L
F
K
K
I
R
--
G
G
--
V
--
F
Y
---
I
--
P
----
E
-
Y
--
L
N
-------
R
S
-------
V
A
T
L
----
L
M
H
M
L
Q
V
D
P
L
K
R
A
-----
T
I
K
D
I
R
E
H
E
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
204
Blastp_CBE
55.09
33%
-44
- C2 -
-
3NCG
6.7
-
?
A:
[24-389]
---------------------------------------
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
----
Q
E
Y
A
V
K
V
--
I
N
K
A
--
S
-
A
-
K
-----
N
K
----
D
-
T
---
S
T
I
L
---
R
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
E
---
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
---
E
S
K
---
E
KDC-
D
---
I
K
I
I
D
F
G
L
-
S
-
T
-
C
---
F
Q
-
Q
--
N
-
T
-------
I
G
T
A
Y
Y
I
A
P
E
V
L
--
R
G
-
T
Y
D
------
E
K
-----
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
--
G
--
K
N
E
Y
-----
D
I
L
K
R
V
E
--
T
G
KY
A
--
F
D
---
L
--
P
----
Q
-
W
RT
I
S
-------
D
D
-------
A
K
D
L
----
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
A
T
Q
C
L
E
H
P
------
W
---
I
--------
Q
K
Y
S
--
S
E
T
----
P
T
I
S
D
L
P
S
L
E
S
A
M
TNI
R
Q
F
Q
A
E
K
K
L
A
Q
A
A
L
L
Y
M
A
S
K
L
T
T
L
D
E
T
K
Q
L
T
E
I
F
R
K
L
D
T
N
N
D
G
M
-----
L
D
R
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
132
Blastp_CBE
54.82
40%
-80
- C2 -
-
4FG8
4.0
-
KCC1A_HUMAN
B:
[20-278]
---------------------------------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
----
K
L
V
A
I
K
C
--
I
A
K
--------------------------------
N
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
---
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
---
D
E
D
---
S
----
K
---
I
M
I
S
D
F
G
----------------
G
-
S
V
-
L
S
T
A
-
C
G
T
P
G
Y
V
A
P
E
V
L
--
A
Q
K
P
Y
------
S
K
A
-----
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
--
D
--
E
N
D
A
-----
K
L
F
E
Q
I
L
--
K
A
--
E
--
Y
E
---
F
DS
P
----
Y
-
W
DD
I
S
-------
D
S
-------
A
K
D
F
----
I
R
H
L
M
E
K
D
P
E
K
R
F
-----
T
C
E
Q
A
L
Q
H
P
------
W
---
I
--------
A
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
205
Blastp_CBE
54.36
33%
-39
- C2 -
-
3MWU
6.5
-
?
A:
[24-372]
---------------------------------------
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
----
Q
E
Y
A
V
K
V
--
I
N
K
A
--
S
-
A
-
K
-----
N
K
----
D
-
T
---
S
T
I
L
---
R
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
E
---
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
---
E
S
K
---
E
KDC-
D
---
I
K
I
I
D
F
G
L
-
S
-
T
-
C
---
F
Q
-
Q
--
N
------
D
R
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
R
G
-
T
Y
D
------
E
K
-----
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
--
G
--
K
N
E
Y
-----
D
I
L
K
R
V
E
--
T
G
KY
A
--
F
D
---
L
--
P
----
Q
-
W
RT
I
S
-------
D
D
-------
A
K
D
L
----
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
A
T
Q
C
L
E
H
P
------
W
---
I
--------
Q
K
Y
S
--
S
E
T
----
P
T
I
S
D
L
P
S
L
E
S
A
M
TNI
R
Q
F
Q
A
E
K
K
L
A
Q
A
A
L
L
Y
M
A
S
K
L
T
T
L
D
E
T
K
Q
L
T
E
I
F
R
K
L
D
T
N
N
D
G
M
-----
L
D
R
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
514
Blastp_CBE
54.29
34%
-68
- C2 -
-
2BRB
6.3
-
CHK1_HUMAN
A:
[5-265]
-----------------------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
M
K
--
R
----------
C
----
P
-----
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
509
Blastp_CBE
54.26
34%
-74
- C2 -
-
2BRO
6.6
-
CHK1_HUMAN
A:
[5-265]
-----------------------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
M
K
--
R
----------
C
----
P
-----
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
Blastp_CBE
54.20
43%
-20
- C2 -
-
4CZU
4.8
-
CIPKN_ARATH
D:
[10-279]
------------------------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
----
D
N
V
A
I
K
V
--
I
D
K
E
--
K
V
L
-
K
-----
N
K
----
M
-
I
---
A
Q
I
K
---
R
E
I
S
T
M
K
L
I
K
-
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
L
K
E
---
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
A
N
---
G
----
A
---
L
K
V
S
D
F
G
L
-
S
-
A
-
L
PQ-
Q
V
R
E
--
D
-
G
L
-
L
H
D
T
-
C
G
T
P
N
Y
V
A
P
E
V
I
--
N
N
K
G
Y
D
-----
G
A
K
-----
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
--
D
--
S
N
L
T
-----
S
L
Y
K
K
I
F
--
K
A
--
E
--
F
T
---
C
--
P
----
P
-
W
--
F
S
-------
A
S
-------
A
K
K
L
----
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
E
V
I
E
N
E
------
W
---
F
--------
K
K
G
Y
--
K
A
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
515
Blastp_CBE
54.12
34%
-69
- C2 -
-
2BR1
6.2
-
CHK1_HUMAN
A:
[5-265]
-----------------------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
M
K
--
R
----------
C
----
P
-----
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
449
Blastp_CBE
54.09
34%
-71
- C2 -
-
2YDI
4.4
-
CHK1_HUMAN
A:
[5-265]
-----------------------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
M
K
--
R
-
A
-
V
-----
D
C
----
P
-----
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
136
Blastp_CBE
54.04
40%
-88
- C2 -
-
4FG9
5.2
-
KCC1A_HUMAN
B:
[20-278]
---------------------------------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
----
K
L
V
A
I
K
C
--
I
A
K
---------------------------------
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
---
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
---
D
E
D
---
S
----
K
---
I
M
I
S
D
F
--------------------
V
-
L
S
T
A
-
C
G
T
P
G
Y
V
A
P
E
V
L
--
A
Q
K
P
Y
------
S
K
A
-----
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
--
D
--
E
N
D
A
-----
K
L
F
E
Q
I
L
--
K
A
--
E
--
Y
E
---
F
DS
P
----
Y
-
W
DD
I
S
-------
D
S
-------
A
K
D
F
----
I
R
H
L
M
E
K
D
P
E
K
R
F
-----
T
C
E
Q
A
L
Q
H
P
------
W
---
I
--------
A
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
Blastp_CBE
54.04
43%
-24
- C2 -
-
4CZT
5.2
-
CIPKN_ARATH
C:
[10-275]
------------------------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
----
D
N
V
A
I
K
V
--
I
D
K
E
--
K
V
L
-
K
-----
N
K
----
M
-
I
---
A
Q
I
K
---
R
E
I
S
T
M
K
L
I
K
-
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
L
K
E
---
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
A
N
---
G
----
A
---
L
K
V
S
D
F
G
L
-
S
-
A
-
L
PQ-
Q
V
R
E
--
D
-
G
L
-
L
H
T
T
-
C
G
T
P
N
Y
V
A
P
E
V
I
--
N
N
K
G
Y
D
-----
G
A
K
-----
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
--
D
--
S
N
L
T
-----
S
L
Y
K
K
I
F
--
K
A
--
E
--
F
T
---
C
--
P
----
P
-
W
--
F
S
-------
A
S
-------
A
K
K
L
----
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
E
V
I
E
N
E
------
W
---
F
--------
K
K
G
Y
--
K
A
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
Blastp_CBE
53.99
43%
-15
- C2 -
-
4CZT
4.7
-
CIPKN_ARATH
D:
[10-279]
------------------------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
----
D
N
V
A
I
K
V
--
I
D
K
E
--
K
V
L
-
K
-----
N
K
----
M
-
I
---
A
Q
I
K
---
R
E
I
S
T
M
K
L
I
K
-
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
L
K
E
---
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
A
N
---
G
----
A
---
L
K
V
S
D
F
G
L
-
S
-
A
-
L
PQ-
Q
V
R
E
--
D
-
G
L
-
L
H
T
T
-
C
G
T
P
N
Y
V
A
P
E
V
I
--
N
N
K
G
Y
D
-----
G
A
K
-----
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
--
D
--
S
N
L
T
-----
S
L
Y
K
K
I
F
--
K
A
--
E
--
F
T
---
C
--
P
----
P
-
W
--
F
S
-------
A
S
-------
A
K
K
L
----
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
E
V
I
E
N
E
------
W
---
F
--------
K
K
G
Y
--
K
A
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
Blastp_CBE
53.96
43%
-20
- C2 -
-
4CZU
5.6
-
CIPKN_ARATH
C:
[10-280]
------------------------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
----
D
N
V
A
I
K
V
--
I
D
K
E
--
K
V
L
-
K
-----
N
K
----
M
-
I
---
A
Q
I
K
---
R
E
I
S
T
M
K
L
I
K
-
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
L
K
E
---
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
A
N
---
G
----
A
---
L
K
V
S
D
F
G
L
-
S
-
A
-
L
PQ-
Q
V
R
E
--
D
-
G
L
-
L
H
D
T
-
C
G
T
P
N
Y
V
A
P
E
V
I
--
N
N
K
G
Y
D
-----
G
A
K
-----
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
--
D
--
S
N
L
T
-----
S
L
Y
K
K
I
F
--
K
A
--
E
--
F
T
---
C
--
P
----
P
-
W
--
F
S
-------
A
S
-------
A
K
K
L
----
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
E
V
I
E
N
E
------
W
---
F
--------
K
K
G
Y
--
K
A
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
206
Blastp_CBE
53.95
33%
-38
- C2 -
-
3IGO
4.9
-
?
A:
[24-367]
---------------------------------------
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
----
Q
E
Y
A
V
K
V
--
I
N
K
A
--
S
-
A
-
K
-----
N
K
------
T
---
S
T
I
L
---
R
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
E
---
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
---
E
S
K
---
E
KDC-
D
---
I
K
I
I
D
F
G
L
-
S
-
T
-
C
---
F
Q
-
Q
--
N
-
T
---------
T
A
Y
Y
I
A
P
E
V
L
--
R
G
-
T
Y
D
------
E
K
-----
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
--
G
--
K
N
E
Y
-----
D
I
L
K
R
V
E
--
T
G
KY
A
--
F
D
---
L
--
P
----
Q
-
W
RT
I
S
-------
D
D
-------
A
K
D
L
----
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
A
T
Q
C
L
E
H
P
------
W
---
I
--------
Q
K
Y
S
--
S
E
T
----
P
T
I
S
D
L
P
S
L
E
S
A
M
TNI
R
Q
F
Q
A
E
K
K
L
A
Q
A
A
L
L
Y
M
A
S
K
L
T
T
L
D
E
T
K
Q
L
T
E
I
F
R
K
L
D
T
N
N
D
G
M
-----
L
D
R
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
137
Blastp_CBE
53.80
40%
-89
- C2 -
-
4FG9
6.0
-
KCC1A_HUMAN
A:
[20-278]
---------------------------------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
----
K
L
V
A
I
K
C
--
I
A
K
E
---------------------------
E
---
N
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
---
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
---
D
E
D
---
S
----
K
---
I
M
I
S
D
F
------------------------------
P
G
Y
V
A
P
E
V
L
--
A
Q
K
P
Y
------
S
K
A
-----
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
--
D
--
E
N
D
A
-----
K
L
F
E
Q
I
L
--
K
A
--
E
--
Y
E
---
F
DS
P
----
Y
-
W
DD
I
S
-------
D
S
-------
A
K
D
F
----
I
R
H
L
M
E
K
D
P
E
K
R
F
-----
T
C
E
Q
A
L
Q
H
P
------
W
---
I
--------
A
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
Blastp_CBE
53.66
43%
-17
- C2 -
-
4CZT
3.5
-
CIPKN_ARATH
A:
[10-277]
------------------------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
----
D
N
V
A
I
K
V
--
I
D
K
E
--
K
V
L
-
K
-----
N
K
----
M
-
I
---
A
Q
I
K
---
R
E
I
S
T
M
K
L
I
K
-
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
L
K
E
---
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
A
N
---
G
----
A
---
L
K
V
S
D
F
G
L
-
S
-
A
-
L
PQ-
Q
V
R
E
--
D
-
G
L
-
L
H
T
T
-
C
G
T
P
N
Y
V
A
P
E
V
I
--
N
N
K
G
Y
D
-----
G
A
K
-----
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
--
D
--
S
N
L
T
-----
S
L
Y
K
K
I
F
--
K
A
--
E
--
F
T
---
C
--
P
----
P
-
W
--
F
S
-------
A
S
-------
A
K
K
L
----
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
E
V
I
E
N
E
------
W
---
F
--------
K
K
G
Y
--
K
A
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
442
Blastp_CBE
53.65
34%
-70
- C2 -
-
4HYH
7.8
-
CHK1_HUMAN
A:
[5-265]
-----------------------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
M
K
-------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
118
Blastp_CBE
53.63
36%
-66
- C2 -
-
6BAB
7.3
-
KCC2D_MOUSE
D:
[10-299]
----------------------------------
R
F
-
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
----
Q
E
Y
A
A
K
I
--
I
N
T
K
--
K
-
L
-
S
-----
A
R
----
D
-
H
---
Q
K
L
E
---
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
---
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
K
---
S
----
K
GAA
V
K
L
A
D
F
G
L
-
A
-
I
-
E
---
V
Q
-
G
--
D
-
Q
Q
-
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
--
R
K
D
P
Y
------
G
K
P
-----
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
--
D
--
E
D
Q
H
-----
R
L
Y
Q
Q
I
K
--
A
G
--
A
--
Y
D
---
F
--
P
SPEW
D
-
T
--
V
T
-------
P
E
-------
A
K
D
L
----
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
L
K
H
P
------
W
---
I
CQRSTVAS
M
M
H
R
--
Q
E
T
V
---
D
C
L
K
K
F
N
A
R
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
507
Blastp_CBE
53.42
34%
-66
- C2 -
-
2C3K
8.2
-
CHK1_HUMAN
A:
[6-265]
------------------------------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
M
K
--
R
----------
C
----
P
-----
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
408
Blastp_CBE
53.40
34%
-76
- C2 -
-
3TKH
5.7
-
CHK1_HUMAN
A:
[5-265]
-----------------------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
----------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
407
Blastp_CBE
53.39
34%
-73
- C2 -
-
3TKI
7.2
-
CHK1_HUMAN
A:
[5-265]
-----------------------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
M
K
-------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
400
Blastp_CBE
53.36
34%
-67
- C2 -
-
2HXQ
6.9
-
CHK1_HUMAN
A:
[4-264]
-----------------------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
M
K
--
R
----------
C
----
P
-----
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
296
Blastp_CBE
53.35
36%
-77
- C2 -
-
2JAM
2.0
-
KCC1G_HUMAN
A:
[11-268]
---------------------------------------
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
----
K
L
F
A
L
K
C
--
I
K
K
--------------
S
----
S
-
L
------
E
---
N
E
I
A
V
L
K
K
I
K
-
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
G
V
Y
T
E
---
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
Y
LTP
E
E
N
---
S
----
K
---
I
M
I
T
D
F
G
L
-
S
-
K
-
M
---
E
--
Q
--
N
-
G
I
-
M
S
T
A
-
C
G
T
P
G
Y
V
A
P
E
V
L
--
A
Q
K
P
Y
------
S
K
A
-----
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
--
E
--
E
T
E
S
-----
K
L
F
E
K
I
K
--
E
G
--
Y
YE
F
E
---
S
--
P
----
F
-
W
DD
I
S
-------
E
S
-------
A
K
D
F
----
I
C
H
L
L
E
K
D
P
N
E
R
Y
-----
T
C
E
K
A
L
S
H
P
------
W
---
I
--------
D
G
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
441
Blastp_CBE
53.30
34%
-69
- C2 -
-
4HYI
6.8
-
CHK1_HUMAN
A:
[5-265]
-----------------------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
M
K
--
R
---------------
P
-----
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
401
Blastp_CBE
53.22
34%
-68
- C2 -
-
2HXL
6.2
-
CHK1_HUMAN
A:
[4-264]
-----------------------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
M
K
--
R
----------
C
----
P
-----
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
502
Blastp_CBE
53.19
34%
-68
- C2 -
-
2CGX
3.7
-
CHK1_HUMAN
A:
[6-265]
------------------------------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
M
K
--
R
----------
C
----
P
-----
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
554
Blastp_CBE
53.13
37%
-80
- C2 -
-
2CN5
6.2
-
CHK2_HUMAN
A:
[18-283]
---------------------------------------
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
----
K
K
V
A
I
K
I
--
I
S
K
R
-------------------------
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
G
-
E
--
T
-
S
L
-
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
--
E
--
H
R
T
Q
V----
S
L
K
D
Q
I
T
--
S
G
--
K
--
Y
------------
N
-
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
503
Blastp_CBE
53.18
34%
-70
- C2 -
-
2CGW
4.3
-
CHK1_HUMAN
A:
[6-265]
------------------------------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
M
K
--
R
---------------
P
-----
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
504
Blastp_CBE
53.13
34%
-68
- C2 -
-
2CGV
5.1
-
CHK1_HUMAN
A:
[6-265]
------------------------------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
M
K
--
R
----------
C
----
P
-----
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
505
Blastp_CBE
53.04
34%
-73
- C2 -
-
2CGU
5.5
-
CHK1_HUMAN
A:
[6-265]
------------------------------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
M
K
--
R
----------
C
----
P
-----
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
399
Blastp_CBE
53.04
34%
-72
- C2 -
-
2HY0
8.3
-
CHK1_HUMAN
A:
[4-264]
-----------------------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
M
K
-------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
133
Blastp_CBE
53.02
40%
-90
- C2 -
-
4FG8
5.3
-
KCC1A_HUMAN
A:
[20-278]
---------------------------------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
----
K
L
V
A
I
K
C
--
I
A
K
----------------------------
E
---
N
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
---
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
---
D
E
D
---
S
----
K
---
I
M
I
S
D
F
-----------------------------
T
P
G
Y
V
A
P
E
V
L
--
A
Q
K
P
Y
------
S
K
A
-----
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
--
D
--
E
N
D
A
-----
K
L
F
E
Q
I
L
--
K
A
--
E
--
Y
E
---
F
DS
P
----
Y
-
W
DD
I
S
-------
D
S
-------
A
K
D
F
----
I
R
H
L
M
E
K
D
P
E
K
R
F
-----
T
C
E
Q
A
L
Q
H
P
------
W
---
I
--------
A
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
453
Blastp_CBE
52.98
34%
-67
- C2 -
-
2X8I
6.1
-
CHK1_HUMAN
A:
[5-265]
-----------------------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
M
-------------------------
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
510
Blastp_CBE
52.95
34%
-70
- C2 -
-
2BRN
5.8
-
CHK1_HUMAN
A:
[6-265]
------------------------------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
M
K
--
R
----------
C
----
P
-----
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
471
Blastp_CBE
52.94
34%
-71
- C2 -
-
4QYH
7.1
-
CHK1_HUMAN
A:
[5-265]
-----------------------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
M
K
-------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
511
Blastp_CBE
52.93
34%
-68
- C2 -
-
2BRM
6.1
-
CHK1_HUMAN
A:
[7-265]
-------------------------------------
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
M
--------------
C
----
P
-----
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
454
Blastp_CBE
52.86
34%
-69
- C2 -
-
2X8D
5.0
-
CHK1_HUMAN
A:
[5-265]
-----------------------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
M
K
--
R
-
A
-
V
-----
D
C
----
P
-----
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
508
Blastp_CBE
52.80
34%
-70
- C2 -
-
2C3J
4.9
-
CHK1_HUMAN
A:
[6-265]
------------------------------------
V
E
D
W
D
L
V
Q
T
L
G
E
---
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
M
K
--
R
---------------------
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
499
Blastp_CBE
52.74
34%
-66
- C2 -
-
1ZLT
5.2
-
CHK1_HUMAN
A:
[5-265]
-----------------------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
M
K
--
R
----------
C
----
P
-----
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
465
Blastp_CBE
52.72
34%
-73
- C2 -
-
1NVQ
8.4
-
CHK1_HUMAN
A:
[5-265]
-----------------------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
M
K
-------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
521
Blastp_CBE
52.64
34%
-72
- C2 -
-
4FSU
8.1
-
CHK1_HUMAN
A:
[4-264]
-----------------------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
A
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
--------------------------
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
501
Blastp_CBE
52.65
34%
-65
- C2 -
-
3NLB
6.3
-
CHK1_HUMAN
A:
[6-265]
------------------------------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
M
K
--
R
---------------------
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
260
Blastp_CBE
52.64
32%
-99
- C2 -
-
5XZV
5.3
-
RAD53_YEAST
A:
[200-465]
-----------------------------------------
I
D
E
V
V
G
Q
G
A
F
A
T
V
K
K
A
I
E
R
T
T
G
----
K
T
F
A
V
K
I
--
I
S
K
R
--
K
-
V
-
I
-----
G
N
------
M
---
D
G
V
T
---
R
E
L
E
V
L
Q
K
L
N
-
H
P
R
I
V
R
L
K
G
F
Y
E
D
T
E
S
Y
Y
M
V
M
E
F
V
S
G
G
D
L
M
D
F
V
A
A
H
G
A
V
G
E
---
D
A
G
R
E
I
S
R
Q
I
L
T
A
I
K
Y
I
H
S
M
G
I
S
H
R
D
L
K
P
D
N
I
L
---
I
---
E
Q
D
---
D
PV--
L
---
V
K
I
T
D
F
G
L
-
A
-
K
------------------------
L
A
Y
V
A
P
E
V
I
---------------
N
EYSSL
V
D
M
W
S
M
G
C
L
V
Y
V
I
L
T
G
H
L
P
F
------
S
T
Q
D
-----
Q
L
Y
K
Q
I
G
--
R
G
--
S
-------
L
--
K
----
D
-
F
R-
I
S
-------
E
E
-------
A
R
D
F
----
I
D
S
L
---
D
P
N
N
-------
T
A
A
K
A
L
N
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
461
Blastp_CBE
52.60
34%
-70
- C2 -
-
2WMR
3.8
-
CHK1_HUMAN
A:
[7-265]
-------------------------------------
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
M
--------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
464
Blastp_CBE
52.59
34%
-73
- C2 -
-
1NVR
9.2
-
CHK1_HUMAN
A:
[5-265]
-----------------------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
M
K
-------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
473
Blastp_CBE
52.55
34%
-68
- C2 -
-
4QYG
5.9
-
CHK1_HUMAN
A:
[5-265]
-----------------------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
M
K
-------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
457
Blastp_CBE
52.53
34%
-77
- C2 -
-
2WMV
4.4
-
CHK1_HUMAN
A:
[7-265]
-------------------------------------
E
D
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
M
--------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
402
Blastp_CBE
52.42
34%
-71
- C2 -
-
2HOG
7.8
-
CHK1_HUMAN
A:
[4-264]
-----------------------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
M
K
-------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
305
Blastp_CBE
52.42
34%
-10
- C2 -
-
2F7X
6.1
-
KAPCA_BOVIN
E:
[33-298]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
---
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
295
Blastp_CBE
52.42
36%
-74
- C2 -
-
2JAM
2.6
-
KCC1G_HUMAN
B:
[11-268]
---------------------------------------
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
----
K
L
F
A
L
K
C
--
I
K
K
--------------
S
----
S
-
L
------
E
---
N
E
I
A
V
L
K
K
I
K
-
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
G
V
Y
T
E
---
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
Y
LTP
E
E
N
---
S
----
K
---
I
M
I
T
D
F
G
L
-
S
-
K
-
M
---
E
--
Q
--
N
-
G
I
-
M
S
T
A
-
C
G
T
P
G
Y
V
A
P
E
V
L
--
A
Q
K
P
Y
------
S
K
A
-----
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
--
E
--
E
T
E
S
-----
K
L
F
E
K
I
K
--
E
G
--
Y
YE
F
E
---
S
--
P
----
F
-
W
DD
I
S
-------
E
S
-------
A
K
D
F
----
I
C
H
L
L
E
K
D
P
N
E
R
Y
-----
T
C
E
K
A
L
S
H
P
------
W
---
I
--------
D
G
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
558
Blastp_CBE
52.36
37%
-85
- C2 -
-
2YCR
7.0
-
CHK2_HUMAN
A:
[12-277]
---------------------------------------
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
----
K
K
V
A
I
K
I
--
I
S
K
--------------------------
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
G
-
E
--
T
-
S
L
-
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
--
E
--
H
R
T
Q
V----
S
L
K
D
Q
I
T
--
S
G
--
K
--
Y
------------
N
-
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
474
Blastp_CBE
52.36
34%
-70
- C2 -
-
4QYF
6.0
-
CHK1_HUMAN
A:
[5-267]
-----------------------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
M
K
-------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
536
Blastp_CBE
52.34
37%
-82
- C2 -
-
4BDF
4.7
-
CHK2_HUMAN
A:
[18-283]
---------------------------------------
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
----
K
K
V
A
I
K
I
--
I
S
K
--------------------------
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
G
-
E
--
T
-
S
L
-
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
--
E
--
H
R
T
Q
V----
S
L
K
D
Q
I
T
--
S
G
--
K
--
Y
------------
N
-
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
475
Blastp_CBE
52.31
34%
-72
- C2 -
-
4QYE
7.0
-
CHK1_HUMAN
A:
[5-265]
-----------------------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
M
K
-------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
532
Blastp_CBE
52.24
37%
-88
- C2 -
-
4BDJ
5.4
-
CHK2_HUMAN
A:
[18-283]
---------------------------------------
Y
I
M
S
K
T
L
-----
G
E
V
K
L
A
F
E
R
K
T
C
----
K
K
V
A
I
K
I
--
I
S
K
--------------------------
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
--
E
--
T
-
S
L
-
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
--
E
--
H
R
T
Q
V----
S
L
K
D
Q
I
T
--
S
G
--
K
--
Y
------------
N
-
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
349
Blastp_CBE
52.27
34%
-12
- C2 -
-
2UZT
6.1
-
KAPCA_BOVIN
A:
[18-283]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
---
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
445
Blastp_CBE
52.24
34%
-75
- C2 -
-
2YM6
5.3
-
CHK1_HUMAN
A:
[7-265]
-------------------------------------
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
M
---------------------------
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
472
Blastp_CBE
52.23
34%
-69
- C2 -
-
4QYG
7.2
-
CHK1_HUMAN
B:
[5-265]
-----------------------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
M
K
-------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
539
Blastp_CBE
52.22
37%
-86
- C2 -
-
4BDC
3.7
-
CHK2_HUMAN
A:
[18-283]
---------------------------------------
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
----
K
K
V
A
I
K
I
--
I
S
K
--------------------------
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
--
E
--
T
-
S
L
-
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
--
E
--
H
R
T
Q
V----
S
L
K
D
Q
I
T
--
S
G
--
K
--
Y
------------
N
-
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
459
Blastp_CBE
52.21
34%
-78
- C2 -
-
2WMT
2.8
-
CHK1_HUMAN
A:
[8-265]
--------------------------------------
D
W
D
L
V
Q
T
L
G
-----
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
M
--------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
347
Blastp_CBE
52.07
34%
-7
- C2 -
-
2UZV
6.3
-
KAPCA_BOVIN
A:
[18-283]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
---
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
306
Blastp_CBE
52.01
34%
-12
- C2 -
-
2F7E
6.0
-
KAPCA_BOVIN
E:
[33-298]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
---
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
Blastp_CBE
51.98
50%
-29
- C2 -
-
6E4W
9.0
-
?
A:
[15-401]
------------------------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
----
H
K
V
A
V
K
I
--
L
N
R
Q
--
K
-
I
R
S
-----
L
D
----
V
-
V
---
G
K
I
R
---
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
---
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
H
---
M
----
N
---
A
K
I
A
D
F
G
L
-
S
-
N
-
M
----
M
-
S
--
D
-
G
E
-
F
L
R
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
G
R
L
Y
A
-----
G
P
E
-----
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
--
D
--
D
H
V
P
-----
T
L
F
K
K
I
C
--
D
G
--
I
--
F
Y
---
T
--
P
----
Q
-
Y
--
L
N
-------
P
S
-------
V
I
S
L
----
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
R
E
H
E
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
540
Blastp_CBE
51.91
37%
-90
- C2 -
-
4BDB
3.7
-
CHK2_HUMAN
A:
[18-283]
---------------------------------------
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
----
K
K
V
A
I
K
I
--
I
S
K
-------------------------
L
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
--
E
--
T
-
S
L
-
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
--
E
--
H
R
T
Q
V----
S
L
K
D
Q
I
T
--
S
G
--
K
--
Y
------------
N
-
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
500
Blastp_CBE
51.95
34%
-70
- C2 -
-
5DLS
7.4
-
CHK1_HUMAN
A:
[6-265]
------------------------------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
M
--------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
498
Blastp_CBE
51.91
34%
-69
- C2 -
-
2GDO
6.8
-
CHK1_HUMAN
A:
[5-265]
-----------------------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
M
K
-------------
C
----
P
-----
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
463
Blastp_CBE
51.91
34%
-71
- C2 -
-
1NVS
7.1
-
CHK1_HUMAN
A:
[5-265]
-----------------------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
M
K
-------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
302
Blastp_CBE
51.92
34%
-11
- C2 -
-
2OJF
5.3
-
KAPCA_BOVIN
E:
[33-298]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
---
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
Blastp_CBE
51.92
50%
-30
- C2 -
-
6E4U
9.3
-
AAPK1_RAT
A:
[15-397]
------------------------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
----
H
K
V
A
V
K
I
--
L
N
R
Q
--
K
-
I
R
S
-----
L
D
----
V
-
V
---
G
K
I
R
---
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
---
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
H
---
M
----
N
---
A
K
I
A
D
F
G
L
-
S
-
N
-
M
----
M
-
S
--
D
-
G
E
-
F
L
R
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
G
R
L
Y
A
-----
G
P
E
-----
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
--
D
--
D
H
V
P
-----
T
L
F
K
K
I
C
--
D
G
--
I
--
F
Y
---
T
--
P
----
Q
-
Y
--
L
N
-------
P
S
-------
V
I
S
L
----
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
R
E
H
E
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
209
Blastp_CBE
51.91
35%
-63
- C2 -
-
2WEI
5.7
-
?
A:
[24-279]
---------------------------------------
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
----
Q
E
Y
A
V
K
V
--
I
N
K
A
--
S
-
A
-
K
-----
N
K
----
D
-
T
---
S
T
I
L
---
R
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
E
---
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
---
E
S
K
---
E
KDC-
D
---
I
K
I
I
D
F
G
L
-
S
-
T
-
C
---
F
Q
-
Q
--
N
-
T
K
-
M
K
D
R
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
R
G
-
T
Y
D
------
E
K
-----
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
--
G
--
K
N
E
Y
-----
D
I
L
K
R
V
E
--
T
G
KY
A
--
F
D
---
L
--
P
----
Q
-
W
RT
I
S
-------
D
D
-------
A
K
D
L
----
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
A
T
Q
C
L
E
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
467
Blastp_CBE
51.87
34%
-70
- C2 -
-
4RVM
7.4
-
CHK1_HUMAN
A:
[5-265]
-----------------------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
M
K
-------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
259
Blastp_CBE
51.87
32%
-89
- C2 -
-
5XZV
3.1
-
?
B:
[200-467]
-----------------------------------------
I
D
E
V
V
G
Q
G
A
F
A
T
V
K
K
A
I
E
R
T
T
G
----
K
T
F
A
V
K
I
--
I
S
K
R
--
K
-----------------
M
---
D
G
V
T
---
R
E
L
E
V
L
Q
K
L
N
-
H
P
R
I
V
R
L
K
G
F
Y
E
D
T
E
S
Y
Y
M
V
M
E
F
V
S
G
G
D
L
M
D
F
V
A
A
H
G
A
V
G
E
---
D
A
G
R
E
I
S
R
Q
I
L
T
A
I
K
Y
I
H
S
M
G
I
S
H
R
D
L
K
P
D
N
I
L
---
I
---
E
Q
D
---
D
PV--
L
---
V
K
I
T
D
F
G
L
----------------------
T
F
-
C
G
T
L
A
Y
V
A
P
E
V
I
--------------
R
N
EYSSL
V
D
M
W
S
M
G
C
L
V
Y
V
I
L
T
G
H
L
P
F
S
--
G
--
S
T
Q
D
-----
Q
L
Y
K
Q
I
G
--
R
G
--
S
--
Y
H
EGP
L
--
K
----
D
-
F
R-
I
S
-------
E
E
-------
A
R
D
F
----
I
D
S
L
L
Q
V
D
P
N
N
R
S
-----
T
A
A
K
A
L
N
H
P
------
W
---
I
--------
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
409
Blastp_CBE
51.86
34%
-75
- C2 -
-
2R0U
6.9
-
CHK1_HUMAN
A:
[5-265]
-----------------------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
---
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
M
K
-------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
506
Blastp_CBE
51.82
34%
-73
- C2 -
-
2C3L
4.4
-
CHK1_HUMAN
A:
[5-265]
-----------------------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
M
K
--
R
-----------------------
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
451
Blastp_CBE
51.80
34%
-75
- C2 -
-
2XEZ
5.2
-
CHK1_HUMAN
A:
[7-265]
-------------------------------------
E
D
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
M
--------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
469
Blastp_CBE
51.79
34%
-71
- C2 -
-
4RVK
7.6
-
CHK1_HUMAN
A:
[5-265]
-----------------------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
M
K
-------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
446
Blastp_CBE
51.76
34%
-78
- C2 -
-
2YM5
5.7
-
CHK1_HUMAN
A:
[8-265]
--------------------------------------
D
W
D
L
V
Q
T
L
G
-----
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
M
--------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
470
Blastp_CBE
51.73
34%
-68
- C2 -
-
4QYH
7.0
-
CHK1_HUMAN
B:
[5-265]
-----------------------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
M
K
-------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
410
Blastp_CBE
51.71
34%
-72
- C2 -
-
2QHN
4.9
-
CHK1_HUMAN
A:
[5-265]
-----------------------------------
F
V
E
D
W
D
L
V
Q
T
L
G
----
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
M
K
-------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
535
Blastp_CBE
51.70
37%
-83
- C2 -
-
4BDG
3.8
-
CHK2_HUMAN
A:
[18-283]
---------------------------------------
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
----
K
K
V
A
I
K
I
--
I
S
K
--------------------------
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
G
-
E
--
T
-
S
L
-
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
--
E
--
H
R
T
Q
V----
S
L
K
D
Q
I
T
--
S
G
--
K
--
Y
------------
N
-
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
513
Blastp_CBE
51.60
34%
-68
- C2 -
-
2BRG
5.0
-
CHK1_HUMAN
A:
[7-265]
-------------------------------------
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
M
K
------------------------
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
452
Blastp_CBE
51.57
34%
-74
- C2 -
-
2XEY
6.3
-
CHK1_HUMAN
A:
[6-265]
------------------------------------
V
E
D
W
D
L
V
Q
T
L
G
----
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
--------------------------
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
198
Blastp_CBE
51.56
37%
4
- C2 -
-
2Y7J
5.5
-
PHKG2_HUMAN
C:
[91-363]
----------------------------------
E
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
----
H
E
F
A
V
K
I
ME
V
T
A
E
--
R
-
L
-
S
PEQL-
E
E
----
V
-
R
---
E
A
T
R
---
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
A
L
S
E
---
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
---
D
D
N
---
M
----
Q
---
I
R
L
S
D
F
G
F
-
S
-
C
H
L
---
E
P
-
G
--
E
-
K
L
-
R
E
L
--
C
G
T
P
G
Y
L
A
P
E
I
L
--
K
C
S
M
D
E
THPGY
G
K
E
-----
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
--
H
--
R
R
Q
I
-----
L
M
L
R
M
I
M
--
E
G
--
Q
--
Y
------------
Q
-
F
--
S
S
-------
P
E
WDDRSST
V
K
D
L
----
I
S
R
L
L
Q
V
D
P
E
A
R
L
-----
T
A
E
Q
A
L
Q
H
P
------
F
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
512
Blastp_CBE
51.52
34%
-71
- C2 -
-
2BRH
5.9
-
CHK1_HUMAN
A:
[6-265]
------------------------------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
---------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
411
Blastp_CBE
51.51
34%
-71
- C2 -
-
2QHM
5.1
-
CHK1_HUMAN
A:
[5-265]
-----------------------------------
F
V
E
D
W
D
L
V
Q
T
L
G
----
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
M
K
-------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
304
Blastp_CBE
51.50
34%
-12
- C2 -
-
2F7Z
7.3
-
KAPCA_BOVIN
E:
[33-298]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
---
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
455
Blastp_CBE
51.48
34%
-75
- C2 -
-
2WMX
5.2
-
CHK1_HUMAN
A:
[7-265]
-------------------------------------
E
D
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
M
--------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Blastp_CBE
51.47
50%
-32
- C2 -
-
6C9J
9.1
-
AAPK1_HUMAN
A:
[13-368]
------------------------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
----
H
K
V
A
V
K
I
--
L
N
R
Q
--
K
-
I
R
S
-----
L
D
----
V
-
V
---
G
K
I
R
---
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
---
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
H
---
M
----
N
---
A
K
I
A
D
F
G
L
-
S
-
N
-
M
----
M
-
S
--
D
-
G
E
-
F
L
R
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
G
R
L
Y
A
-----
G
P
E
-----
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
--
D
--
D
H
V
P
-----
T
L
F
K
K
I
C
--
D
G
--
I
--
F
Y
---
T
--
P
----
Q
-
Y
--
L
N
-------
P
S
-------
V
I
S
L
----
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
R
E
H
E
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
303
Blastp_CBE
51.43
34%
-12
- C2 -
-
2OH0
5.8
-
KAPCA_BOVIN
E:
[33-298]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
---
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
538
Blastp_CBE
51.35
37%
-93
- C2 -
-
4BDD
4.5
-
CHK2_HUMAN
A:
[18-283]
---------------------------------------
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
----
K
K
V
A
I
K
I
--
I
S
K
--------------------------
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
-----
T
-
S
L
-
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
--
E
--
H
R
T
Q
V----
S
L
K
D
Q
I
T
--
S
G
--
K
--
Y
------------
N
-
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
232
Blastp_CBE
51.28
34%
13
- C2 -
-
3HZT
6.0
-
?
A:
[6-363]
---------------------------------------
Y
Q
R
V
K
K
L
G
S
G
A
Y
G
E
V
L
L
C
K
D
K
L
T
G
----
A
E
R
A
I
K
I
--
I
K
K
S
--
S
-
V
-
T
-----
T
T
SNSG
A
-
L
---
L
D
------
E
V
A
V
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
R
N
Y
Y
L
V
M
E
V
Y
R
G
G
E
L
F
D
E
I
I
L
R
Q
K
F
S
E
---
V
D
A
A
V
I
M
K
Q
V
L
S
G
T
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
----
R
DAL
I
K
I
V
D
F
G
L
S
A
-
H
-
F
---
E
V
---------------
G
T
A
Y
Y
I
A
P
E
V
L
--
R
-
K
K
Y
D
------
E
K
-----
C
D
V
W
S
C
G
V
I
L
Y
I
L
L
C
G
Y
P
P
F
G
--
G
--
Q
T
D
Q
-----
E
I
L
K
R
V
E
--
K
G
--
K
--
F
------------
S
-
F
--
D
P
-------
P
D
WTQVSDE
A
K
Q
L
----
V
K
L
M
L
T
Y
E
P
S
K
R
I
-----
S
A
E
E
A
L
N
H
P
------
W
IVK
F
--------
C
S
Q
----------
V
G
K
H
A
L
T
G
A
L
G
N
M
---
K
K
F
Q
S
S
Q
K
L
A
Q
A
A
M
L
F
M
G
S
K
L
T
T
L
E
E
T
K
E
L
T
Q
I
F
R
Q
L
D
N
N
G
D
G
Q
-----
L
D
R
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
541
Blastp_CBE
51.25
37%
-81
- C2 -
-
4BDA
4.7
-
CHK2_HUMAN
A:
[18-283]
---------------------------------------
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
----
K
K
V
A
I
K
I
--
I
S
K
--------------------------
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
--
E
--
T
-
S
L
-
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
--
E
--
H
R
T
Q
V----
S
L
K
D
Q
I
T
--
S
G
--
K
--
Y
------------
N
-
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Blastp_CBE
51.22
50%
-27
- C2 -
-
5KQ5
8.9
-
?
A:
[15-399]
------------------------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
----
H
K
V
A
V
K
I
--
L
N
R
Q
--
K
-
I
R
S
-----
L
D
----
V
-
V
---
G
K
I
R
---
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
---
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
H
---
M
----
N
---
A
K
I
A
D
F
G
L
-
S
-
N
-
M
----
M
-
S
--
D
-
G
E
-
F
L
R
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
G
R
L
Y
A
-----
G
P
E
-----
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
--
D
--
D
H
V
P
-----
T
L
F
K
K
I
C
--
D
G
--
I
--
F
Y
---
T
--
P
----
Q
-
Y
--
L
N
-------
P
S
-------
V
I
S
L
----
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
R
E
H
E
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
346
Blastp_CBE
51.20
34%
-9
- C2 -
-
2UZW
5.0
-
KAPCA_BOVIN
E:
[18-283]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
---
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
201
Blastp_CBE
51.19
34%
-47
- C2 -
-
3LIJ
3.9
-
?
A:
[39-350]
---------------------------------------
Y
Q
R
V
K
K
L
G
S
---
G
E
V
L
L
C
R
D
K
V
T
H
----
V
E
R
A
I
K
I
--
I
R
K
--------------
S
----
S
-
N
---
S
K
L
L
---
E
E
V
A
V
L
K
L
L
D
-
H
P
N
I
M
K
L
Y
D
F
F
E
D
K
R
N
Y
Y
L
V
M
E
C
Y
K
G
G
E
L
F
D
E
I
I
H
R
M
K
F
N
E
---
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
E
----
K
DAL
I
K
I
V
D
F
G
L
-
S
-
A
-
V
---
F
E
-
N
--
Q
-
K
K
-
M
K
E
R
-
L
G
T
A
Y
Y
I
A
P
E
V
L
--
R
-
K
K
Y
D
------
E
K
-----
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
G
--
G
--
Q
T
D
Q
-----
E
I
L
R
K
V
E
--
K
G
KY
T
--
F
D
---
S
--
P
----
E
-
W
KN
V
S
-------
E
G
-------
A
K
D
L
----
I
K
Q
M
L
Q
F
D
S
Q
R
R
I
-----
S
A
Q
Q
A
L
E
H
P
------
W
---
I
KE------
M
C
S
K
--
K
E
S
------
L
P
S
L
A
N
A
I
E
N
M
---
R
K
F
Q
N
S
Q
K
L
A
Q
A
A
L
L
Y
M
A
S
-------------
K
L
T
S
Q
E
E
T
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
348
Blastp_CBE
51.16
34%
-9
- C2 -
-
2UZU
5.0
-
KAPCA_BOVIN
E:
[18-283]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
---
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
530
Blastp_CBE
51.03
34%
-72
- C2 -
-
4FSN
7.8
-
CHK1_HUMAN
A:
[1-263]
---------------------------------
A
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
-
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
M
-------------------------
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Blastp_CBE
50.97
50%
-30
- C2 -
-
4QFS
9.5
-
A:
[15-401]
------------------------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
----
H
K
V
A
V
K
I
--
L
N
R
Q
--
K
-
I
R
S
-----
L
D
----
V
-
V
---
G
K
I
R
---
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
---
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
H
---
M
----
N
---
A
K
I
A
D
F
G
L
-
S
-
N
-
M
----
M
-
S
--
D
-
G
E
-
F
L
R
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
G
R
L
Y
A
-----
G
P
E
-----
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
--
D
--
D
H
V
P
-----
T
L
F
K
K
I
C
--
D
G
--
I
--
F
Y
---
T
--
P
----
Q
-
Y
--
L
N
-------
P
S
-------
V
I
S
L
----
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
R
E
H
E
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Blastp_CBE
50.92
50%
-25
- C2 -
-
6E4T
8.8
-
?
A:
[15-401]
------------------------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
----
H
K
V
A
V
K
I
--
L
N
R
Q
--
K
-
I
R
S
-----
L
D
----
V
-
V
---
G
K
I
R
---
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
---
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
H
---
M
----
N
---
A
K
I
A
D
F
G
L
-
S
-
N
-
M
----
M
-
S
--
D
-
G
E
-
F
L
R
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
G
R
L
Y
A
-----
G
P
E
-----
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
--
D
--
D
H
V
P
-----
T
L
F
K
K
I
C
--
D
G
--
I
--
F
Y
---
T
--
P
----
Q
-
Y
--
L
N
-------
P
S
-------
V
I
S
L
----
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
R
E
H
E
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
468
Blastp_CBE
50.69
34%
-75
- C2 -
-
4RVL
6.8
-
CHK1_HUMAN
A:
[5-265]
-----------------------------------
F
V
E
D
W
D
L
V
Q
T
L
G
------
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
M
K
-------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
534
Blastp_CBE
50.59
37%
-88
- C2 -
-
4BDH
3.6
-
CHK2_HUMAN
A:
[18-283]
---------------------------------------
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
----
K
K
V
A
I
K
I
--
I
S
K
--------------------------
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
G
-
E
--
T
-
S
L
-
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
--
E
--
H
R
T
Q
V----
S
L
K
D
Q
I
T
--
S
G
--
K
--
Y
------------
N
-
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
Blastp_CBE
50.59
50%
-29
- C2 -
-
4CFH
8.5
-
AAPK1_RAT
A:
[32-346]
------------------------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
----
H
K
V
A
V
K
I
--
L
N
R
Q
--
K
-
I
R
S
-----
L
D
----
V
-
V
---
G
K
I
R
---
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
---
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
H
---
M
----
N
---
A
K
I
A
D
F
G
L
-
S
-
N
-
M
----
M
-
S
--
D
-
G
E
-
F
L
R
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
G
R
L
Y
A
-----
G
P
E
-----
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
--
D
--
D
H
V
P
-----
T
L
F
K
K
I
C
--
D
G
--
I
--
F
Y
---
T
--
P
----
Q
-
Y
--
L
N
-------
P
S
-------
V
I
S
L
----
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
R
E
H
E
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
225
Blastp_CBE
50.56
38%
-86
- C2 -
-
3ZXT
4.4
-
DAPK1_HUMAN
A:
[19-274]
---------------------------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
----
L
Q
Y
A
A
K
F
--
I
K
K
R
--
R
-
T
---------------
R
---
E
D
I
E
---
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
---
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
R
----VPKP
R
---
I
K
I
I
D
F
G
L
-
A
H
K
-
I
---
D
-------------------
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
--
D
T
K
Q
-----
E
T
L
A
N
V
S
--
A
V
--
N
--
Y
E
---
F
--
E
----
D
-
E
--
Y
F
-------
S
N
-------
T
S
A
L
AKDF
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
447
Blastp_CBE
50.49
34%
-73
- C2 -
-
2YM4
4.8
-
CHK1_HUMAN
A:
[5-265]
-----------------------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
----------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
------
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Blastp_CBE
50.37
50%
-25
- C2 -
-
4QFR
10.2
-
?
A:
[15-401]
------------------------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
----
H
K
V
A
V
K
I
--
L
N
R
Q
--
K
-
I
R
S
-----
L
D
----
V
-
V
---
G
K
I
R
---
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
---
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
H
---
M
----
N
---
A
K
I
A
D
F
G
L
-
S
-
N
-
M
----
M
-
S
--
D
-
G
E
-
F
L
R
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
G
R
L
Y
A
-----
G
P
E
-----
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
--
D
--
D
H
V
P
-----
T
L
F
K
K
I
C
--
D
G
--
I
--
F
Y
---
T
--
P
----
Q
-
Y
--
L
N
-------
P
S
-------
V
I
S
L
----
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
R
E
H
E
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
444
Blastp_CBE
50.31
34%
-76
- C2 -
-
2YM7
5.1
-
CHK1_HUMAN
A:
[7-265]
-------------------------------------
E
D
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
----------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
443
Blastp_CBE
50.19
34%
-75
- C2 -
-
2YM8
6.3
-
CHK1_HUMAN
A:
[8-265]
--------------------------------------
D
W
D
L
V
Q
T
L
G
-----
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
----------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
456
Blastp_CBE
50.18
34%
-73
- C2 -
-
2WMW
4.7
-
CHK1_HUMAN
A:
[7-265]
-------------------------------------
E
D
W
D
L
V
Q
T
L
G
------
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
M
--------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
553
Blastp_CBE
50.17
37%
-89
- C2 -
-
2CN8
5.1
-
CHK2_HUMAN
A:
[18-283]
---------------------------------------
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
----
K
K
V
A
I
K
I
--
I
S
K
--------------------------
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
-----
T
-
S
L
-
M
R
T
L
-
C
--
P
T
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
--
E
--
H
---V----
S
L
K
D
Q
I
T
--
S
G
--
K
--
Y
------------
N
-
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
462
Blastp_CBE
50.10
34%
-67
- C2 -
-
2WMQ
3.0
-
CHK1_HUMAN
A:
[7-265]
-------------------------------------
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
---------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
--------
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
450
Blastp_CBE
49.95
34%
-78
- C2 -
-
2XF0
6.0
-
CHK1_HUMAN
A:
[5-265]
-----------------------------------
F
V
E
D
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
---------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
265
Blastp_CBE
49.78
36%
-26
- C2 -
-
5VJA
5.8
-
DAPK3_HUMAN
D:
[7-268]
---------------------------------------
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
----
K
E
Y
A
A
K
F
--
I
K
K
R
--
R
-
L
-
S
-------V---
S
-
R
---
E
E
I
E
---
R
E
V
N
I
L
R
E
I
R
-
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
---
E
K
E
S
L
T
E
---
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
-----VPNP
R
---
I
K
L
I
D
F
G
I
-
A
H
K
-
I
---
E
A
-
G
--
N
-
E
--
F
K
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
--
E
T
K
Q
-----
E
T
L
T
N
I
S
AV
N
Y
--
D
--
F
D
---
E
--
E
----
Y
-
F
--
S
N
-------
T
S
EL-----
A
K
D
F
----
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
T
I
A
Q
S
L
E
H
S
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
547
Blastp_CBE
49.60
37%
-94
- C2 -
-
2XM8
6.5
-
CHK2_HUMAN
A:
[18-283]
---------------------------------------
Y
I
M
S
K
T
L
-----
G
E
V
K
L
A
F
E
R
K
T
C
----
K
K
V
A
I
K
I
-------------------------------
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
-----
T
-
S
L
-
M
R
T
L
-
C
G
---
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
--
E
--
H
R
T
Q
V----
S
L
K
D
Q
I
T
--
S
G
--
K
--
Y
------------
N
-
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
458
Blastp_CBE
49.16
34%
-77
- C2 -
-
2WMU
4.2
-
CHK1_HUMAN
A:
[9-265]
---------------------------------------
W
D
L
V
Q
T
L
G
E
-----
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
---------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
448
Blastp_CBE
48.93
34%
-75
- C2 -
-
2YM3
4.8
-
CHK1_HUMAN
A:
[8-265]
--------------------------------------
D
W
D
L
V
Q
T
L
G
-----
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
--
V
D
---------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
131
Blastp_CBE
48.12
38%
-13
- C2 -
-
6T6F
6.3
-
?
A:
[16-289]
---------------------------------------
F
E
F
K
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
----
K
L
F
A
V
K
C
--
I
P
K
K
--
A
-
L
-
K
GK---
E
S
-----------
S
I
E
---
N
E
I
A
V
L
R
K
I
K
-
H
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
---
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
---
Y
YSQ
D
E
E
---
S
----
K
---
I
M
I
S
D
F
G
L
-
S
--------------------------
P
G
Y
V
A
P
E
V
L
--
A
Q
K
P
Y
------
S
K
A
-----
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
--
D
--
E
N
D
S
-----
K
L
F
E
Q
I
L
--
K
A
--
E
--
Y
E
---
F
DS
P
----
Y
-
W
DD
I
S
-------
D
S
-------
A
K
D
F
----
I
R
N
L
M
E
K
D
P
N
K
R
Y
-----
T
C
E
Q
A
A
R
H
P
------
W
---
I
--------
A
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
345
Blastp_CBE
48.08
34%
-19
- C2 -
-
1CDK
8.3
-
KAPCA_PIG
A:
[32-297]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
----
N
H
F
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
Y
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
548
Blastp_CBE
47.93
37%
-26
- C2 -
-
2XBJ
7.5
-
CHK2_HUMAN
A:
[18-283]
---------------------------------------
Y
I
M
S
K
T
L
G
S
G
A
-
G
E
V
K
L
A
F
E
R
K
T
C
----
K
K
V
A
I
K
I
--
I
S
K
----------------------A--
L
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
-----
T
-
S
L
-
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
--
E
--
H
R
T
Q
V----
S
L
K
D
Q
I
T
--
S
G
--
K
--
Y
------------
N
-
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
370
Blastp_CBE
47.92
34%
-26
- C2 -
-
3L9L
6.7
-
KAPCA_HUMAN
B:
[34-298]
-----------------------
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
477
Blastp_CBE
47.90
34%
-21
- C2 -
-
4HPT
5.9
-
KAPCA_MOUSE
E:
[33-297]
-----------------------
P
S
----
Q
N
--
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
485
Blastp_CBE
47.82
34%
-22
- C2 -
-
1REJ
6.4
-
KAPCA_MOUSE
A:
[33-297]
-----------------------
P
S
----
Q
N
--
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
352
Blastp_CBE
47.81
34%
-23
- C2 -
-
3MVJ
4.9
-
KAPCA_HUMAN
E:
[54-318]
-----------------------
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
460
Blastp_CBE
47.79
34%
-72
- C2 -
-
2WMS
4.1
-
CHK1_HUMAN
A:
[7-265]
-------------------------------------
E
D
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
V
T
E
----
E
A
V
A
V
K
I
-------------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-----
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
-
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
PS
D
S
C
Q
-----
E
Y
S
D
W
K
E
--
K
K
--
T
--
Y
L
---
N
--
P
----
W
K
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
------
W
---
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
340
Blastp_CBE
47.74
34%
-21
- C2 -
-
2VO7
7.8
-
KAPCA_BOVIN
A:
[33-298]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
130
Blastp_CBE
47.73
38%
-6
- C2 -
-
6T6F
5.8
-
?
B:
[16-289]
---------------------------------------
F
E
F
K
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
----
K
L
F
A
V
K
C
--
I
P
K
K
--
A
-
L
-
K
GK---
E
S
-----------
S
I
E
---
N
E
I
A
V
L
R
K
I
K
-
H
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
---
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
---
Y
YSQ
D
E
E
---
S
----
K
---
I
M
I
S
D
F
G
-----------------------------
P
G
Y
V
A
P
E
V
L
--
A
Q
K
P
Y
------
S
K
A
-----
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
--
D
--
E
N
D
S
-----
K
L
F
E
Q
I
L
--
K
A
--
E
--
Y
E
---
F
DS
P
----
Y
-
W
DD
I
S
-------
D
S
-------
A
K
D
F
----
I
R
N
L
M
E
K
D
P
N
K
R
Y
-----
T
C
E
Q
A
A
R
H
P
------
W
---
I
--------
A
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
488
Blastp_CBE
47.72
34%
-26
- C2 -
-
1FMO
4.9
-
KAPCA_MOUSE
E:
[33-297]
-----------------------
P
S
----
Q
N
--
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
395
Blastp_CBE
47.71
33%
-23
- C2 -
-
2GNF
4.9
-
KAPCA_BOVIN
A:
[32-297]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
A
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
344
Blastp_CBE
47.70
34%
-21
- C2 -
-
1CDK
7.8
-
KAPCA_PIG
B:
[32-297]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
----
N
H
F
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
Y
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
325
Blastp_CBE
47.69
34%
-24
- C2 -
-
1VEB
6.8
-
KAPCA_BOVIN
A:
[32-297]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
293
Blastp_CBE
47.55
34%
-20
- C2 -
-
2GNL
5.6
-
KAPCA_BOVIN
A:
[32-297]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
A
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
527
Blastp_CBE
47.52
34%
-24
- C2 -
-
4NTT
4.6
-
KAPCA_MOUSE
B:
[33-297]
-----------------------
P
S
----
Q
N
--
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
369
Blastp_CBE
47.47
34%
-23
- C2 -
-
3OOG
4.3
-
KAPCA_HUMAN
A:
[34-298]
-----------------------
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
222
Blastp_CBE
47.47
38%
-51
- C2 -
-
3ZXT
4.2
-
DAPK1_HUMAN
D:
[19-274]
---------------------------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
----
L
Q
Y
A
A
K
F
--
I
-----------------V---
S
-
R
---
E
D
I
E
---
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
----
T
E
---
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
-
A
H
K
-
I
---
D
-----------------
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
--
D
T
K
Q
-----
E
T
L
A
N
V
S
--
A
V
--
N
--
Y
E
---
F
--
E
----
D
-
E
--
Y
F
-------
S
N
-------
T
S
A
L
AKDF
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
368
Blastp_CBE
47.44
34%
-18
- C2 -
-
3OVV
6.6
-
KAPCA_HUMAN
A:
[34-298]
-----------------------
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
404
Blastp_CBE
47.43
33%
-21
- C2 -
-
2GNH
5.8
-
KAPCA_BOVIN
A:
[32-297]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
A
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
294
Blastp_CBE
47.40
34%
-24
- C2 -
-
2GNJ
5.3
-
KAPCA_BOVIN
A:
[32-297]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
A
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
519
Blastp_CBE
47.35
33%
-23
- C2 -
-
3L9M
6.0
-
KAPCA_HUMAN
B:
[34-298]
-----------------------
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
494
Blastp_CBE
47.35
33%
-22
- C2 -
-
2JDV
6.3
-
KAPCA_BOVIN
A:
[33-298]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
334
Blastp_CBE
47.36
34%
-22
- C2 -
-
3DND
4.1
-
KAPCA_BOVIN
A:
[32-297]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
333
Blastp_CBE
47.35
34%
-20
- C2 -
-
3DNE
4.9
-
KAPCA_BOVIN
A:
[32-297]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
157
Blastp_CBE
47.32
37%
14
- C2 -
-
3HX4
4.4
-
?
A:
[31-308]
--------------
D
H
L
H
A
T
P
G
M
F
V
----
Q
H
ST
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
----
Q
E
C
A
V
K
V
--
I
S
K
--------DK---
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
-
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
--
A
N
E
Y
-----
D
I
L
K
K
V
E
--
K
G
KY
T
--
F
E
---
L
--
P
----
Q
-
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
406
Blastp_CBE
47.31
33%
-19
- C2 -
-
1XH9
7.3
-
KAPCA_BOVIN
A:
[32-297]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
E
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
T
D
F
G
L
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
331
Blastp_CBE
47.30
34%
-18
- C2 -
-
4YXS
4.3
-
KAPCA_BOVIN
A:
[32-297]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
403
Blastp_CBE
47.27
33%
-24
- C2 -
-
2GNI
5.3
-
KAPCA_BOVIN
A:
[32-297]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
A
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
481
Blastp_CBE
47.28
34%
-22
- C2 -
-
3IDC
5.7
-
KAPCA_MOUSE
A:
[33-297]
-----------------------
P
S
----
Q
N
--
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
328
Blastp_CBE
47.27
34%
-25
- C2 -
-
1STC
8.3
-
KAPCA_BOVIN
E:
[32-297]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
341
Blastp_CBE
47.26
34%
-21
- C2 -
-
2C1B
6.5
-
KAPCA_BOVIN
A:
[33-298]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
528
Blastp_CBE
47.21
34%
-25
- C2 -
-
4NTT
4.9
-
KAPCA_MOUSE
A:
[33-297]
-----------------------
P
S
----
Q
N
--
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
520
Blastp_CBE
47.22
33%
-20
- C2 -
-
3L9M
5.6
-
KAPCA_HUMAN
A:
[34-298]
-----------------------
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
330
Blastp_CBE
47.21
34%
-19
- C2 -
-
1Q8T
4.5
-
KAPCA_BOVIN
A:
[32-297]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
482
Blastp_CBE
47.20
34%
-25
- C2 -
-
3IDB
6.2
-
KAPCA_MOUSE
A:
[33-297]
-----------------------
P
S
----
Q
N
--
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
337
Blastp_CBE
47.15
34%
-18
- C2 -
-
4IE9
4.5
-
KAPCA_BOVIN
A:
[33-298]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
518
Blastp_CBE
47.11
33%
-23
- C2 -
-
3L9N
4.5
-
KAPCA_HUMAN
A:
[34-301]
-----------------------
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
537
Blastp_CBE
47.08
37%
-39
- C2 -
-
4BDE
4.4
-
CHK2_HUMAN
A:
[18-283]
---------------------------------------
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
----
K
K
V
A
I
K
I
--
I
S
K
----------------------A--
L
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
-----
T
-
S
L
-
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
--
E
--
H
R
T
Q
V----
S
L
K
D
Q
I
T
--
S
G
--
K
--
Y
------------
N
-
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
437
Blastp_CBE
47.11
34%
-21
- C2 -
-
2GU8
7.2
-
KAPCA_HUMAN
A:
[20-284]
-----------------------
P
S
----
Q
N
--
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
E
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
416
Blastp_CBE
47.09
33%
-19
- C2 -
-
4Z84
5.8
-
KAPCA_BOVIN
A:
[33-298]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
478
Blastp_CBE
47.08
34%
-16
- C2 -
-
4DIN
6.9
-
KAPCA_MOUSE
A:
[33-297]
-----------------------
P
S
----
Q
N
--
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
531
Blastp_CBE
47.03
37%
-36
- C2 -
-
4BDK
4.4
-
CHK2_HUMAN
A:
[18-283]
---------------------------------------
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
----
K
K
V
A
I
K
I
--
I
S
K
----------------------A--
L
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
G
-
E
--
T
-
S
L
-
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
--
E
--
H
R
T
Q
V----
S
L
K
D
Q
I
T
--
S
G
--
K
--
Y
------------
N
-
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
389
Blastp_CBE
47.05
36%
19
- C2 -
-
2YAA
5.7
-
DAPK2_MOUSE
B:
[14-275]
---------------------------------------
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
----
L
E
Y
A
A
K
F
--
I
K
K
R
--
Q
-
S
-
R
-----
A
S
RRGV
C
-
R
---
E
E
I
E
---
R
E
V
S
I
L
R
Q
V
L
-
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
S
L
S
E
---
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
K
---
N
IPIP
H
---
I
K
L
I
D
F
G
L
-
A
-
H
-----
E
I
-
E
--
D
-
G
V
E
F
K
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
--
D
T
K
Q
-----
E
T
L
A
N
I
T
--
A
V
--
S
--
Y
D
---
F
D-
E
----
E
-
F
--
F
S
-------
Q
T
SEL----
A
K
D
F
----
I
R
K
L
L
V
K
E
T
R
K
R
L
-----
T
I
Q
E
A
L
R
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
517
Blastp_CBE
47.01
33%
-15
- C2 -
-
2VO0
6.6
-
KAPCA_BOVIN
A:
[33-298]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
492
Blastp_CBE
47.04
33%
-15
- C2 -
-
2UW4
3.8
-
KAPCA_BOVIN
A:
[33-298]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
-
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
329
Blastp_CBE
47.03
34%
-21
- C2 -
-
1Q8U
6.0
-
KAPCA_BOVIN
A:
[32-297]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
335
Blastp_CBE
47.02
34%
-26
- C2 -
-
6E9L
6.9
-
KAPCA_BOVIN
A:
[33-298]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
372
Blastp_CBE
47.01
34%
-19
- C2 -
-
3AGM
6.4
-
KAPCA_HUMAN
A:
[34-298]
-----------------------
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
289
Blastp_CBE
46.99
34%
-25
- C2 -
-
1YDS
4.6
-
KAPCA_BOVIN
E:
[32-297]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
559
Blastp_CBE
46.95
34%
-17
- C2 -
-
6MM8
3.1
-
KAPCA_MOUSE
C:
[22-297]
-----------------------
P
S
----
Q
N
--
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
290
Blastp_CBE
46.94
34%
-23
- C2 -
-
1YDR
5.1
-
KAPCA_BOVIN
E:
[32-297]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
327
Blastp_CBE
46.87
34%
-22
- C2 -
-
1SVE
6.9
-
KAPCA_BOVIN
A:
[32-297]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
288
Blastp_CBE
46.83
34%
-21
- C2 -
-
1YDT
6.0
-
KAPCA_BOVIN
E:
[32-297]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
479
Blastp_CBE
46.80
34%
-19
- C2 -
-
3OW3
4.7
-
KAPCA_MOUSE
A:
[33-297]
-----------------------
P
S
----
Q
N
--
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
371
Blastp_CBE
46.80
34%
-24
- C2 -
-
3L9L
6.8
-
KAPCA_HUMAN
A:
[34-298]
-----------------------
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
493
Blastp_CBE
46.76
33%
-15
- C2 -
-
2UVX
3.9
-
KAPCA_BOVIN
A:
[33-298]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
495
Blastp_CBE
46.79
33%
-14
- C2 -
-
2JDT
5.9
-
KAPCA_BOVIN
A:
[33-298]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
367
Blastp_CBE
46.76
34%
-19
- C2 -
-
3OWP
5.7
-
KAPCA_HUMAN
A:
[34-298]
-----------------------
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
476
Blastp_CBE
46.73
34%
-21
- C2 -
-
2ERZ
4.9
-
KAPCA_MOUSE
E:
[34-298]
-----------------------
P
S
----
Q
N
--
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
365
Blastp_CBE
46.73
34%
-22
- C2 -
-
3P0M
5.9
-
KAPCA_HUMAN
A:
[34-298]
-----------------------
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
231
Blastp_CBE
46.72
37%
21
- C2 -
-
2Y0A
2.4
-
DAPK1_HUMAN
A:
[13-274]
---------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
----
L
Q
Y
A
A
K
F
--
I
K
K
R
--
R
-
T
-
K
-----
S
S
RRGV
S
-
R
---
E
D
I
E
---
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
---
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
-
A
H
K
-
I
---
D
F
-
G
--
N
-
E
--
F
K
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
--
D
T
K
Q
-----
E
T
L
A
N
V
S
--
A
V
--
N
--
Y
E
---
F
--
E
----
D
-
E
--
Y
F
-------
S
N
-------
T
S
A
L
AKDF
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
154
Blastp_CBE
46.72
37%
8
- C2 -
-
4IH8
5.1
-
?
A:
[45-335]
---------------------------------
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
----
Q
E
C
A
V
K
V
--
I
S
K
R
--
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
-----
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
-
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
--
A
N
E
Y
-----
D
I
L
K
K
V
E
--
K
G
KY
T
--
F
E
---
L
--
P
----
Q
-
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
427
Blastp_CBE
46.71
33%
-22
- C2 -
-
1Q24
6.5
-
KAPCA_BOVIN
A:
[32-297]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
390
Blastp_CBE
46.70
36%
24
- C2 -
-
2YAA
4.7
-
DAPK2_MOUSE
A:
[14-275]
---------------------------------------
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
----
L
E
Y
A
A
K
F
--
I
K
K
R
--
Q
-
S
-
R
-----
A
S
RRGV
C
-
R
---
E
E
I
E
---
R
E
V
S
I
L
R
Q
V
L
-
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
S
L
S
E
---
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
K
---
N
IPIP
H
---
I
K
L
I
D
F
G
L
-
A
-
H
-----
E
I
-
E
--
D
-
G
V
E
F
K
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
--
D
T
K
Q
-----
E
T
L
A
N
I
T
--
A
V
--
S
--
Y
D
---
F
D-
E
----
E
-
F
--
F
S
-------
Q
T
SEL----
A
K
D
F
----
I
R
K
L
L
V
K
E
T
R
K
R
L
-----
T
I
Q
E
A
L
R
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
496
Blastp_CBE
46.66
34%
-19
- C2 -
-
1BX6
5.7
-
KAPCA_MOUSE
A:
[33-297]
-----------------------
P
S
----
Q
N
--
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
414
Blastp_CBE
46.69
33%
-18
- C2 -
-
4Z83
6.7
-
KAPCA_BOVIN
E:
[32-297]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
326
Blastp_CBE
46.66
34%
-24
- C2 -
-
1SVG
7.9
-
KAPCA_BOVIN
A:
[32-297]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
516
Blastp_CBE
46.62
34%
-19
- C2 -
-
1JBP
5.9
-
KAPCA_MOUSE
E:
[33-297]
-----------------------
P
S
----
Q
N
--
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
E
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
486
Blastp_CBE
46.60
34%
-22
- C2 -
-
1RE8
7.4
-
KAPCA_MOUSE
A:
[33-297]
-----------------------
P
S
----
Q
N
--
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
355
Blastp_CBE
46.58
34%
-20
- C2 -
-
5UZK
8.3
-
KAPCA_HUMAN
A:
[34-298]
-----------------------
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
378
Blastp_CBE
46.57
34%
-19
- C2 -
-
3AGL
7.2
-
KAPCA_HUMAN
A:
[34-298]
-----------------------
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
484
Blastp_CBE
46.54
34%
-16
- C2 -
-
1REK
8.8
-
KAPCA_MOUSE
A:
[33-297]
-----------------------
P
S
----
Q
N
--
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
376
Blastp_CBE
46.56
34%
-17
- C2 -
-
3VQH
6.7
-
KAPCA_HUMAN
A:
[34-298]
-----------------------
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
422
Blastp_CBE
46.52
34%
-25
- C2 -
-
2QUR
5.6
-
KAPCA_MOUSE
A:
[33-297]
-----------------------
P
S
----
Q
N
--
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLPN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
312
Blastp_CBE
46.54
34%
-17
- C2 -
-
1SVH
7.8
-
KAPCA_BOVIN
A:
[32-297]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
307
Blastp_CBE
46.52
34%
-20
- C2 -
-
4IJ9
6.6
-
KAPCA_BOVIN
A:
[32-297]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
239
Blastp_CBE
46.49
38%
23
- C2 -
-
6FHB
2.5
-
DAPK1_HUMAN
A:
[22-277]
---------------------------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
----
L
Q
Y
A
A
K
F
--
I
K
K
R
--
R
-
T
-
K
-----
S
S
RRGV
S
-
R
---
E
D
I
E
---
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
---
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
-
A
H
K
-
I
---
D
F
-
G
--
N
-
E
--
F
K
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
--
D
T
K
Q
-----
E
T
L
A
N
V
S
--
A
V
--
N
--
Y
E
---
F
--
E
----
D
-
E
--
Y
F
-------
S
N
-------
T
S
A
L
AKDF
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
350
Blastp_CBE
46.45
34%
-18
- C2 -
-
6C0U
7.1
-
KAPCA_HUMAN
A:
[37-301]
-----------------------
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
338
Blastp_CBE
46.45
34%
-17
- C2 -
-
3ZO4
7.1
-
KAPCA_BOVIN
A:
[33-298]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
332
Blastp_CBE
46.41
34%
-18
- C2 -
-
4YXR
3.7
-
KAPCA_BOVIN
A:
[32-297]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
366
Blastp_CBE
46.39
34%
-13
- C2 -
-
3OXT
5.6
-
KAPCA_HUMAN
A:
[34-298]
-----------------------
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
374
Blastp_CBE
46.38
34%
-18
- C2 -
-
5BX6
3.3
-
KAPCA_HUMAN
A:
[34-298]
-----------------------
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
275
Blastp_CBE
46.37
35%
-43
- C2 -
-
4JXF
3.4
-
PLK4_HUMAN
A:
[6-261]
------------------------------------
I
E
D
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
----
L
E
V
A
I
K
M
--
I
D
K
K
--
A
-
M
-
Y
-----
K
A
G---
M
-
V
---
Q
R
V
Q
---
N
E
V
K
I
H
C
Q
L
K
-
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
--
K
N
R
V
K
P
FSE
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
I
L
H
R
D
L
T
L
S
N
L
L
---
L
---
T
R
N
---
M
----
N
---
I
K
I
A
D
F
G
L
-
A
-
T
Q
L
---
K
M
-
P
--
H
------------------------------------
E
-----
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
--------
V
K
-----
N
T
L
N
K
V
V
--
L
A
--
D
--
Y
E
---
M
--
P
----
S
-
F
--
L
S
-------
I
E
-------
A
K
D
L
----
I
H
Q
L
L
R
R
N
P
A
D
R
L
-----
S
L
S
S
V
L
D
H
P
------
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
336
Blastp_CBE
46.31
34%
-21
- C2 -
-
6E99
7.2
-
KAPCA_BOVIN
A:
[33-298]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
364
Blastp_CBE
46.29
34%
-18
- C2 -
-
3POO
7.2
-
KAPCA_HUMAN
A:
[34-302]
-----------------------
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
490
Blastp_CBE
46.25
33%
-17
- C2 -
-
4AXA
6.7
-
KAPCA_BOVIN
A:
[33-298]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
557
Blastp_CBE
46.27
34%
-26
- C2 -
-
6F14
4.5
-
KAPCA_CRIGR
A:
[34-298]
-----------------------
P
S
----
Q
N
--
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
----
R
V
M
L
V
K
H
K
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
533
Blastp_CBE
46.22
37%
-25
- C2 -
-
4BDI
4.2
-
CHK2_HUMAN
A:
[18-283]
---------------------------------------
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
----
K
K
V
A
I
K
I
--
I
S
K
----------------------A--
L
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
G
-
E
--
T
-
S
L
-
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
--
E
--
H
R
T
Q
V----
S
L
K
D
Q
I
T
--
S
G
--
K
--
Y
------------
N
-
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
311
Blastp_CBE
46.26
34%
-22
- C2 -
-
1XH5
8.4
-
KAPCA_BOVIN
A:
[32-297]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
483
Blastp_CBE
46.25
34%
-18
- C2 -
-
3FJQ
8.0
-
KAPCA_MOUSE
E:
[33-297]
-----------------------
P
S
----
Q
N
--
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
309
Blastp_CBE
46.24
34%
-18
- C2 -
-
1XH8
8.8
-
KAPCA_BOVIN
A:
[32-297]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
228
Blastp_CBE
46.22
38%
26
- C2 -
-
4TXC
7.7
-
DAPK1_HUMAN
A:
[38-293]
---------------------------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
----
L
Q
Y
A
A
K
F
--
I
K
K
R
--
R
-
T
-
K
-----
S
S
RRGV
S
-
R
---
E
D
I
E
---
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
---
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
-
A
H
K
-
I
---
D
F
-
G
--
N
-
E
--
F
K
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
--
D
T
K
Q
-----
E
T
L
A
N
V
S
--
A
V
--
N
--
Y
E
---
F
--
E
----
D
-
E
--
Y
F
-------
S
N
-------
T
S
A
L
AKDF
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
491
Blastp_CBE
46.16
33%
-17
- C2 -
-
2UW7
5.8
-
KAPCA_BOVIN
A:
[33-298]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
489
Blastp_CBE
46.16
34%
-20
- C2 -
-
1ATP
8.2
-
KAPCA_MOUSE
E:
[33-297]
-----------------------
P
S
----
Q
N
--
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
354
Blastp_CBE
46.16
34%
-19
- C2 -
-
3MVJ
4.9
-
KAPCA_HUMAN
A:
[54-318]
-----------------------
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
342
Blastp_CBE
46.16
34%
-20
- C2 -
-
2C1A
6.3
-
KAPCA_BOVIN
A:
[33-298]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
377
Blastp_CBE
46.09
34%
-17
- C2 -
-
3AGL
8.0
-
KAPCA_HUMAN
B:
[34-298]
-----------------------
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
310
Blastp_CBE
46.07
34%
-18
- C2 -
-
1XH6
8.6
-
KAPCA_BOVIN
A:
[32-297]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
393
Blastp_CBE
46.02
34%
-18
- C2 -
-
4WB6
8.2
-
KAPCA_HUMAN
B:
[33-297]
-----------------------
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
R
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
362
Blastp_CBE
46.00
34%
-17
- C2 -
-
4UJ2
6.1
-
KAPCA_HUMAN
A:
[34-298]
-----------------------
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
363
Blastp_CBE
45.96
34%
-18
- C2 -
-
4UJ1
5.4
-
KAPCA_HUMAN
A:
[34-298]
-----------------------
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
497
Blastp_CBE
45.89
34%
-19
- C2 -
-
1BKX
4.8
-
KAPCA_MOUSE
A:
[33-297]
-----------------------
P
S
----
Q
N
--
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
180
Blastp_CBE
45.89
37%
15
- C2 -
-
3V51
7.8
-
?
A:
[20-290]
-------------------------------ST
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
----
Q
E
C
A
V
K
V
--
I
S
K
R
--
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
-
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
--
A
N
E
Y
-----
D
I
L
K
K
V
E
--
K
G
KY
T
--
F
E
---
L
--
P
----
Q
-
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
226
Blastp_CBE
45.88
38%
21
- C2 -
-
2YAK
9.5
-
DAPK1_HUMAN
A:
[19-274]
---------------------------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
----
L
Q
Y
A
A
K
F
--
I
K
K
R
--
R
-
T
-
K
-----
S
S
RRGV
S
-
R
---
E
D
I
E
---
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
---
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
-
A
H
K
-
I
---
D
F
-
G
--
N
-
E
--
F
K
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
--
D
T
K
Q
-----
E
T
L
A
N
V
S
--
A
V
--
N
--
Y
E
---
F
--
E
----
D
-
E
--
Y
F
-------
S
N
-------
T
S
A
L
AKDF
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
264
Blastp_CBE
45.83
35%
-41
- C2 -
-
3COK
6.0
-
PLK4_HUMAN
A:
[10-265]
------------------------------------
I
E
D
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
----
L
E
V
A
I
K
M
--
I
D
K
K
--
A
-
M
-
Y
-----
K
A
G---
M
-
V
---
Q
R
V
Q
---
N
E
V
K
I
H
C
Q
L
K
-
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
--
K
N
R
V
K
P
FSE
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
I
L
H
R
D
L
T
L
S
N
L
L
---
L
---
T
R
N
---
M
----
N
---
I
K
I
A
D
F
G
L
-
A
-
T
Q
L
---
K
------------------------------------------
E
-----
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
D
--
T
--
D
T
V
----------
K
V
V
--
L
A
--
D
--
Y
E
---
M
--
P
----
S
-
F
--
L
S
-------
I
E
-------
A
K
D
L
----
I
H
Q
L
L
R
R
N
P
A
D
R
L
-----
S
L
S
S
V
L
D
H
P
------
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
430
Blastp_CBE
45.81
34%
28
- C2 -
-
4NW5
7.6
-
KS6A3_HUMAN
A:
[32-323]
---------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
-
V
K
K
I
S
G
SDAR
Q
L
Y
A
M
K
V
--
L
K
K
A
TL
K
-
V
-
R
-----
D
R
----
V
-
R
---
T
K
M
E
---
R
D
I
L
V
E
--
V
N
-
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
---
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
---
L
---
D
E
E
---
G
----
H
---
I
K
L
T
D
F
G
L
-
S
-
K
-
E
---
S
I
-
D
H-
E
-
K
K
-
A
Y
S
F
-
C
G
T
V
E
Y
M
A
P
E
V
V
---
N
R
R
G
H
-----
T
Q
S
-----
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
--
G
--
K
D
R
K
-----
E
T
M
T
M
I
L
--
K
A
--
K
--
L
G
---
M
--
P
----
Q
-
F
--
L
S
-------
P
E
-------
A
Q
S
L
----
L
R
M
L
F
K
R
N
P
A
N
R
L
GAGPD
G
V
E
E
I
K
R
H
S
FFSTID
W
---
N
--------
K
L
Y
R
--
R
E
I
H
---
P
P
F
K
P
A
T
G
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
174
Blastp_CBE
45.83
37%
16
- C2 -
-
4TZR
6.7
-
?
A:
[19-289]
------------------------------
H
ST
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
----
Q
E
C
A
V
K
V
--
I
S
K
R
--
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
-
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
--
A
N
E
Y
-----
D
I
L
K
K
V
E
--
K
G
KY
T
--
F
E
---
L
--
P
----
Q
-
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
373
Blastp_CBE
45.81
34%
-18
- C2 -
-
5BX7
3.9
-
KAPCA_HUMAN
A:
[34-298]
-----------------------
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
234
Blastp_CBE
45.81
38%
23
- C2 -
-
1WVY
7.4
-
DAPK1_HUMAN
A:
[19-274]
---------------------------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
----
L
Q
Y
A
A
K
F
--
I
K
K
R
--
R
-
T
-
K
-----
S
S
RRGV
S
-
R
---
E
D
I
E
---
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
---
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
-
A
H
K
-
I
---
D
F
-
G
--
N
-
E
--
F
K
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
--
D
T
K
Q
-----
E
T
L
A
N
V
S
--
A
V
--
N
--
Y
E
---
F
--
E
----
D
-
E
--
Y
F
-------
S
N
-------
T
S
A
L
AKDF
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
268
Blastp_CBE
45.75
36%
23
- C2 -
-
5VJA
5.6
-
DAPK3_HUMAN
A:
[7-268]
---------------------------------------
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
----
K
E
Y
A
A
K
F
--
I
K
K
R
--------------RRGV
S
-
R
---
E
E
I
E
---
R
E
V
N
I
L
R
E
I
R
-
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
---
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
K
---
N
VPNP
R
---
I
K
L
I
D
F
G
I
-
A
H
K
-
I
---
E
A
-
G
--
N
-
E
--
F
K
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
--
E
T
K
Q
-----
E
T
L
T
N
I
S
AV
N
Y
--
D
--
F
D
---
E
--
E
----
Y
-
F
--
S
N
-------
T
S
EL-----
A
K
D
F
----
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
T
I
A
Q
S
L
E
H
S
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
267
Blastp_CBE
45.73
36%
20
- C2 -
-
5VJA
5.6
-
DAPK3_HUMAN
B:
[7-268]
---------------------------------------
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
----
K
E
Y
A
A
K
F
--
I
K
K
---------------RRGV
S
-
R
---
E
E
I
E
---
R
E
V
N
I
L
R
E
I
R
-
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
---
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
K
---
N
VPNP
R
---
I
K
L
I
D
F
G
I
-
A
H
K
-
I
---
E
A
-
G
--
N
-
E
--
F
K
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
--
E
T
K
Q
-----
E
T
L
T
N
I
S
AV
N
Y
--
D
--
F
D
---
E
--
E
----
Y
-
F
--
S
N
-------
T
S
EL-----
A
K
D
F
----
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
T
I
A
Q
S
L
E
H
S
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
360
Blastp_CBE
45.67
34%
-16
- C2 -
-
4UJA
6.9
-
KAPCA_HUMAN
A:
[34-298]
-----------------------
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
247
Blastp_CBE
45.68
38%
18
- C2 -
-
5AUZ
5.1
-
DAPK1_HUMAN
A:
[19-274]
---------------------------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
----
L
Q
Y
A
A
K
F
--
I
K
K
R
--
R
-
T
-
K
-----
S
S
RRGV
S
-
R
---
E
D
I
E
---
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
--
E
S
L
T
E
---
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
-
A
H
K
-
I
---
D
F
-
G
--
N
-
E
--
F
K
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
--
D
T
K
Q
-----
E
T
L
A
N
V
S
--
A
V
--
N
--
Y
E
---
F
--
E
----
D
-
E
--
Y
F
-------
S
N
-------
T
S
A
L
AKDF
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
281
Blastp_CBE
45.67
36%
17
- C2 -
-
4YZB
6.2
-
?
A:
[12-292]
-------------------
K
L
A
A
T
P
GMFV
Q
H
ST
A
A
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
V
T
G
----
Q
E
Y
A
V
K
V
--
I
S
K
R
------------
Q
K
----
T
D
K
---
E
L
L
L
---
K
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
N
K
---
R
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
S
--
T
-
K
K
-
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
--
A
N
E
F
-----
D
I
L
K
K
V
E
--
K
G
KF
T
--
F
D
---
L
--
P
----
Q
-
W
KK
V
S
-------
E
P
-------
A
K
D
L
----
I
R
K
M
L
A
Y
V
P
T
M
R
I
-----
S
A
R
D
A
L
E
H
E
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
429
Blastp_CBE
45.64
34%
31
- C2 -
-
4NW6
8.2
-
KS6A3_HUMAN
A:
[32-323]
---------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
-
V
K
K
I
S
G
SDAR
Q
L
Y
A
M
K
V
--
L
K
K
A
TL
K
-
V
-
R
-----
D
R
----
V
-
R
---
T
K
M
E
---
R
D
I
L
V
E
--
V
N
-
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
---
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
---
L
---
D
E
E
---
G
----
H
---
I
K
L
T
D
F
G
L
-
S
-
K
-
E
---
S
I
-
D
H-
E
-
K
K
-
A
Y
S
F
-
C
G
T
V
E
Y
M
A
P
E
V
V
---
N
R
R
G
H
-----
T
Q
S
-----
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
--
G
--
K
D
R
K
-----
E
T
M
T
M
I
L
--
K
A
--
K
--
L
G
---
M
--
P
----
Q
-
F
--
L
S
-------
P
E
-------
A
Q
S
L
----
L
R
M
L
F
K
R
N
P
A
N
R
L
GAGPD
G
V
E
E
I
K
R
H
S
FFSTID
W
---
N
--------
K
L
Y
R
--
R
E
I
H
---
P
P
F
K
P
A
T
G
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
249
Blastp_CBE
45.66
38%
27
- C2 -
-
5AUX
5.1
-
DAPK1_HUMAN
A:
[19-274]
---------------------------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
----
L
Q
Y
A
A
K
F
--
I
K
K
R
--
R
-
T
-
K
-----
S
S
RRGV
S
-
R
---
E
D
I
E
---
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-
S
L
T
E
---
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
-
A
H
K
-
I
---
D
F
-
G
--
N
-
E
--
F
K
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
--
D
T
K
Q
-----
E
T
L
A
N
V
S
--
A
V
--
N
--
Y
E
---
F
--
E
----
D
-
E
--
Y
F
-------
S
N
-------
T
S
A
L
AKDF
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
339
Blastp_CBE
45.64
34%
-17
- C2 -
-
3AG9
7.9
-
KAPCA_BOVIN
B:
[33-315]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
556
Blastp_CBE
45.62
33%
-22
- C2 -
-
3O7L
5.2
-
KAPCA_MOUSE
B:
[33-301]
-----------------------
P
S
----
Q
N
--
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
---
G
R
V
M
L
V
K
H
K
E
S
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
I
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
I
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
262
Blastp_CBE
45.59
38%
22
- C2 -
-
4UV0
1.7
-
DAPK1_HUMAN
A:
[21-276]
---------------------------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
----
L
Q
Y
A
A
K
F
--
I
K
K
R
--
R
-
T
-
K
-----
S
S
RRGV
S
-
R
---
E
D
I
E
---
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
---
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
-
A
H
K
-
I
---
D
F
-
G
--
N
-
E
--
F
K
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
--
D
T
K
Q
-----
E
T
L
A
N
V
S
--
A
V
--
N
--
Y
E
---
F
--
E
----
D
-
E
--
Y
F
-------
S
N
-------
T
S
A
L
AKDF
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
178
Blastp_CBE
45.58
37%
13
- C2 -
-
3V5T
6.1
-
?
A:
[20-289]
-------------------------------ST
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
----
Q
E
C
A
V
K
V
--
I
S
K
R
--
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
-
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
--
A
N
E
Y
-----
D
I
L
K
K
V
E
--
K
G
KY
T
--
F
E
---
L
--
P
----
Q
-
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
375
Blastp_CBE
45.56
34%
-16
- C2 -
-
4UJB
6.5
-
KAPCA_HUMAN
A:
[34-298]
-----------------------
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
250
Blastp_CBE
45.54
38%
19
- C2 -
-
5AUW
5.9
-
DAPK1_HUMAN
A:
[19-274]
---------------------------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
----
L
Q
Y
A
A
K
F
--
I
K
K
R
--
R
-
T
-
K
-----
S
S
RRGV
S
-
R
---
E
D
I
E
---
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
L
T
E
---
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
-
A
H
K
-
I
---
D
F
-
G
--
N
-
E
--
F
K
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
--
D
T
K
Q
-----
E
T
L
A
N
V
S
--
A
V
--
N
--
Y
E
---
F
--
E
----
D
-
E
--
Y
F
-------
S
N
-------
T
S
A
L
AKDF
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
243
Blastp_CBE
45.51
38%
23
- C2 -
-
5AV3
5.3
-
DAPK1_HUMAN
A:
[19-274]
---------------------------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
----
L
Q
Y
A
A
K
F
--
I
K
K
R
--
R
-
T
-
K
-----
S
S
RRGV
S
-
R
---
E
D
I
E
---
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-
S
L
T
E
---
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
-
A
H
K
-
I
---
D
F
-
G
--
N
-
E
--
F
K
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
--
D
T
K
Q
-----
E
T
L
A
N
V
S
--
A
V
--
N
--
Y
E
---
F
--
E
----
D
-
E
--
Y
F
-------
S
N
-------
T
S
A
L
AKDF
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
251
Blastp_CBE
45.48
38%
25
- C2 -
-
5AUV
5.4
-
DAPK1_HUMAN
A:
[19-274]
---------------------------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
----
L
Q
Y
A
A
K
F
--
I
K
K
R
--
R
-
T
-
K
-----
S
S
RRGV
S
-
R
---
E
D
I
E
---
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-
S
L
T
E
---
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
-
A
H
K
-
I
---
D
F
-
G
--
N
-
E
--
F
K
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
--
D
T
K
Q
-----
E
T
L
A
N
V
S
--
A
V
--
N
--
Y
E
---
F
--
E
----
D
-
E
--
Y
F
-------
S
N
-------
T
S
A
L
AKDF
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
221
Blastp_CBE
45.46
38%
26
- C2 -
-
2W4K
5.2
-
DAPK1_HUMAN
A:
[19-274]
---------------------------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
----
L
Q
Y
A
A
K
F
--
I
K
K
R
--
R
-
T
-
K
-----
S
S
RRGV
S
-
R
---
E
D
I
E
---
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
---
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
-
A
H
K
-
I
---
D
F
-
G
--
N
-
E
--
F
K
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
--
D
T
K
Q
-----
E
T
L
A
N
V
S
--
A
V
--
N
--
Y
E
---
F
--
E
----
D
-
E
--
Y
F
-------
S
N
-------
T
S
A
L
AKDF
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
254
Blastp_CBE
45.43
38%
25
- C2 -
-
4PF4
3.9
-
DAPK1_HUMAN
A:
[20-275]
---------------------------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
----
L
Q
Y
A
A
K
F
--
I
K
K
R
--
R
-
T
-
K
-----
S
S
RRGV
S
-
R
---
E
D
I
E
---
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
---
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
-
A
H
K
-
I
---
D
F
-
G
--
N
-
E
--
F
K
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
--
D
T
K
Q
-----
E
T
L
A
N
V
S
--
A
V
--
N
--
Y
E
---
F
--
E
----
D
-
E
--
Y
F
-------
S
N
-------
T
S
A
L
AKDF
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
253
Blastp_CBE
45.38
38%
22
- C2 -
-
5AUT
4.7
-
DAPK1_HUMAN
A:
[19-274]
---------------------------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
----
L
Q
Y
A
A
K
F
--
I
K
K
R
--
R
-
T
-
K
-----
S
S
RRGV
S
-
R
---
E
D
I
E
---
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
--
E
S
L
T
E
---
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
-
A
H
K
-
I
---
D
F
-
G
--
N
-
E
--
F
K
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
--
D
T
K
Q
-----
E
T
L
A
N
V
S
--
A
V
--
N
--
Y
E
---
F
--
E
----
D
-
E
--
Y
F
-------
S
N
-------
T
S
A
L
AKDF
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
162
Blastp_CBE
45.36
37%
4
- C2 -
-
3MA6
5.7
-
?
B:
[29-290]
----------------------------------
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
----
Q
E
C
A
V
K
V
--
I
S
K
R
--
Q
-
V
-
K
QTDK-
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
-
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
--
A
N
E
Y
-----
D
I
L
K
K
V
E
--
K
G
KY
T
--
F
E
---
L
--
P
----
Q
-
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
273
Blastp_CBE
45.35
36%
25
- C2 -
-
3BQR
5.9
-
DAPK3_HUMAN
A:
[7-268]
---------------------------------------
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
----
K
E
Y
A
A
K
F
--
I
K
K
R
--
R
-
L
-
S
-----
S
S
RRGV
S
-
R
---
E
E
I
E
---
R
E
V
N
I
L
R
E
I
R
-
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
---
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
K
---
N
VPNP
R
---
I
K
L
I
D
F
G
I
-
A
H
K
-
I
---
E
A
-
G
--
N
------
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
--
E
T
K
Q
-----
E
T
L
T
N
I
S
AV
N
Y
--
D
--
F
D
---
E
--
E
----
Y
-
F
--
S
N
-------
T
S
EL-----
A
K
D
F
----
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
T
I
A
Q
S
L
E
H
S
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
244
Blastp_CBE
45.33
38%
26
- C2 -
-
5AV2
5.1
-
DAPK1_HUMAN
A:
[19-274]
---------------------------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
----
L
Q
Y
A
A
K
F
--
I
K
K
R
--
R
-
T
-
K
-----
S
S
RRGV
S
-
R
---
E
D
I
E
---
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-
S
L
T
E
---
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
-
A
H
K
-
I
---
D
F
-
G
--
N
-
E
--
F
K
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
--
D
T
K
Q
-----
E
T
L
A
N
V
S
--
A
V
--
N
--
Y
E
---
F
--
E
----
D
-
E
--
Y
F
-------
S
N
-------
T
S
A
L
AKDF
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
266
Blastp_CBE
45.26
36%
17
- C2 -
-
5VJA
5.7
-
DAPK3_HUMAN
C:
[7-268]
---------------------------------------
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
----
K
E
Y
A
A
K
F
--
I
K
K
R
--
R
-
L
-
S
-----
S
-GV--
S
-
R
---
E
E
I
E
---
R
E
V
N
I
L
R
E
I
R
-
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
--
E
K
E
S
L
T
E
---
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
-----VPNP
R
---
I
K
L
I
D
F
G
I
-
A
H
K
-
I
---
E
A
-
G
--
N
-
E
--
F
K
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
--
E
T
K
Q
-----
E
T
L
T
N
I
S
AV
N
Y
--
D
--
F
D
---
E
--
E
----
Y
-
F
--
S
N
-------
T
S
EL-----
A
K
D
F
----
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
T
I
A
Q
S
L
E
H
S
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
420
Blastp_CBE
45.23
33%
-13
- C2 -
-
1XHA
8.1
-
KAPCA_BOVIN
A:
[32-297]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
E
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
L
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
257
Blastp_CBE
45.23
35%
-47
- C2 -
-
4YUR
6.2
-
PLK4_HUMAN
A:
[12-267]
------------------------------------
I
E
D
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
----
L
E
V
A
I
K
M
--
I
D
K
K
--
A
-
M
-
Y
-----
K
A
G---
M
-
V
---
Q
R
V
Q
---
N
E
V
K
I
H
C
Q
L
K
-
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
--
K
N
R
V
K
P
FSE
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
I
L
H
R
D
L
T
L
S
N
L
L
---
L
---
T
R
N
---
M
----
N
---
I
K
I
A
D
F
----------------------------------------------------
G
L
E
-----
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
-------
T
V
K
-----
N
T
L
N
K
V
V
--
L
A
--
D
--
Y
E
---
M
--
P
----
S
-
F
--
L
S
-------
I
E
-------
A
K
D
L
----
I
H
Q
L
L
R
R
N
P
A
D
R
L
-----
S
L
S
S
V
L
D
H
P
------
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
242
Blastp_CBE
45.22
38%
17
- C2 -
-
5AV4
5.5
-
DAPK1_HUMAN
A:
[19-274]
---------------------------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
----
L
Q
Y
A
A
K
F
--
I
K
K
R
--
R
-
T
-
K
-----
S
S
RRGV
S
-
R
---
E
D
I
E
---
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
--
E
S
L
T
E
---
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
-
A
H
K
-
I
---
D
F
-
G
--
N
-
E
--
F
K
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
--
D
T
K
Q
-----
E
T
L
A
N
V
S
--
A
V
--
N
--
Y
E
---
F
--
E
----
D
-
E
--
Y
F
-------
S
N
-------
T
S
A
L
AKDF
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
435
Blastp_CBE
45.15
35%
-26
- C2 -
-
3KN5
4.1
-
B:
[16-277]
------------------------------------------
D
K
P
L
G
E
G
S
F
S
I
C
R
K
C
V
H
K
K
S
N
----
Q
A
F
A
V
K
I
--
I
S
K
R
--
M
-
E
-
A
-----
N
T
-------------
Q
---
K
E
I
T
A
L
K
L
C
E
G
H
P
N
I
V
K
L
H
E
V
F
H
D
Q
L
H
T
F
L
V
M
E
L
L
N
G
G
E
L
F
E
R
I
K
K
K
K
H
F
S
E
---
T
E
A
S
Y
I
M
R
K
L
V
S
A
V
S
H
M
H
D
V
G
V
V
H
R
D
L
K
P
E
N
L
L
---
F
---
T
D
----------LE-
I
K
I
I
D
F
G
F
-
A
-
R
-
L
---
K
P
-
P
----------------------------
N
G
Y
D
------
E
S
-----
C
D
L
W
S
L
G
V
I
L
Y
T
M
L
S
G
Q
V
P
F
Q
SH
D
--
R
S
L
T
CTSAV
E
I
M
K
K
I
K
--
K
G
--
D
--
F
S
---
F
--
E
GEAW
K
-
N
--
V
S
-------
Q
E
-------
A
K
D
L
----
I
Q
G
L
L
T
V
D
P
N
K
R
L
-----
K
M
S
G
L
R
Y
N
E
------
W
---
L
--------
Q
D
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
229
Blastp_CBE
45.14
38%
29
- C2 -
-
6QMO
2.3
-
DAPK1_HUMAN
A:
[22-277]
---------------------------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
----
L
Q
Y
A
A
K
F
--
I
K
K
R
--
R
-
T
-
K
-----
S
S
RRGV
S
-
R
---
E
D
I
E
---
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
---
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
-
A
H
K
-
I
---
D
F
-
G
--
N
-
E
--
F
K
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
--
D
T
K
Q
-----
E
T
L
A
N
V
S
--
A
V
--
N
--
Y
E
---
F
--
E
----
D
-
E
--
Y
F
-------
S
N
-------
T
S
A
L
AKDF
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
148
Blastp_CBE
45.13
37%
6
- C2 -
-
5T6I
5.3
-
?
A:
[62-359]
-------------------------------T-
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
----
Q
E
C
A
V
K
V
--
I
S
K
-----
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KA--
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
-
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
--
A
N
E
Y
-----
D
I
L
K
K
V
E
--
K
G
KY
T
--
F
E
---
L
--
P
----
Q
-
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
170
Blastp_CBE
45.12
37%
16
- C2 -
-
4YJN
6.0
-
?
A:
[20-289]
-------------------------------ST
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
----
Q
E
C
A
V
K
V
--
I
S
K
R
--
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
-
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
--
A
N
E
Y
-----
D
I
L
K
K
V
E
--
K
G
KY
T
--
F
E
---
L
--
P
----
Q
-
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
156
Blastp_CBE
45.03
37%
19
- C2 -
-
3KU2
4.6
-
?
A:
[44-314]
-------------------------------T-
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
----
Q
E
C
A
V
K
V
--
I
S
K
R
--
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
-
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
--
A
N
E
Y
-----
D
I
L
K
K
V
E
--
K
G
KY
T
--
F
E
---
L
--
P
----
Q
-
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
155
Blastp_CBE
45.03
37%
19
- C2 -
-
4IFG
7.6
-
?
A:
[44-319]
-------------------------------T-
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
----
Q
E
C
A
V
K
V
--
I
S
K
R
--
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
-
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
--
A
N
E
Y
-----
D
I
L
K
K
V
E
--
K
G
KY
T
--
F
E
---
L
--
P
----
Q
-
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
252
Blastp_CBE
45.01
38%
17
- C2 -
-
5AUU
6.4
-
DAPK1_HUMAN
A:
[19-274]
---------------------------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
----
L
Q
Y
A
A
K
F
--
I
K
K
R
--
R
-
T
-
K
-----
S
S
RRGV
S
-
R
---
E
D
I
E
---
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
--
E
S
L
T
E
---
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
-
A
H
K
-
I
---
D
F
-
G
--
N
-
E
--
F
K
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
--
D
T
K
Q
-----
E
T
L
A
N
V
S
--
A
V
--
N
--
Y
E
---
F
--
E
----
D
-
E
--
Y
F
-------
S
N
-------
T
S
A
L
AKDF
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
236
Blastp_CBE
45.01
38%
23
- C2 -
-
4B4L
2.4
-
DAPK1_HUMAN
A:
[21-276]
---------------------------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
----
L
Q
Y
A
A
K
F
--
I
K
K
R
--
R
-
T
-
K
-----
S
S
RRGV
S
-
R
---
E
D
I
E
---
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
---
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
-
A
H
K
-
I
---
D
F
-
G
--
N
-
E
--
F
K
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
--
D
T
K
Q
-----
E
T
L
A
N
V
S
--
A
V
--
N
--
Y
E
---
F
--
E
----
D
-
E
--
Y
F
-------
S
N
-------
T
S
A
L
AKDF
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
177
Blastp_CBE
45.01
37%
17
- C2 -
-
4JBV
5.9
-
?
A:
[22-289]
---------------------------------
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
----
Q
E
C
A
V
K
V
--
I
S
K
R
--
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
-
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
--
A
N
E
Y
-----
D
I
L
K
K
V
E
--
K
G
KY
T
--
F
E
---
L
--
P
----
Q
-
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
248
Blastp_CBE
44.99
38%
26
- C2 -
-
5AUY
5.9
-
DAPK1_HUMAN
A:
[19-274]
---------------------------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
----
L
Q
Y
A
A
K
F
--
I
K
K
R
--
R
-
T
-
K
-----
S
S
RRGV
S
-
R
---
E
D
I
E
---
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-
S
L
T
E
---
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
-
A
H
K
-
I
---
D
F
-
G
--
N
-
E
--
F
K
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
--
D
T
K
Q
-----
E
T
L
A
N
V
S
--
A
V
--
N
--
Y
E
---
F
--
E
----
D
-
E
--
Y
F
-------
S
N
-------
T
S
A
L
AKDF
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
233
Blastp_CBE
44.98
38%
23
- C2 -
-
2W4J
4.8
-
DAPK1_HUMAN
A:
[19-274]
---------------------------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
----
L
Q
Y
A
A
K
F
--
I
K
K
R
--
R
-
T
-
K
-----
S
S
RRGV
S
-
R
---
E
D
I
E
---
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
---
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
-
A
H
K
-
I
---
D
F
-
G
--
N
-
E
--
F
K
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
--
D
T
K
Q
-----
E
T
L
A
N
V
S
--
A
V
--
N
--
Y
E
---
F
--
E
----
D
-
E
--
Y
F
-------
S
N
-------
T
S
A
L
AKDF
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
150
Blastp_CBE
44.90
37%
14
- C2 -
-
5JN2
6.1
-
?
A:
[61-340]
-------------------------------ST
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
----
Q
E
C
A
V
K
V
--
I
S
K
R
--
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
-
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
--
A
N
E
Y
-----
D
I
L
K
K
V
E
--
K
G
KY
T
--
F
E
---
L
--
P
----
Q
-
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
274
Blastp_CBE
44.88
36%
19
- C2 -
-
3BHY
5.2
-
DAPK3_HUMAN
A:
[7-268]
---------------------------------------
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
----
K
E
Y
A
A
K
F
--
I
K
K
R
--
R
-
L
-
S
-----
S
S
RRGV
S
-
R
---
E
E
I
E
---
R
E
V
N
I
L
R
E
I
R
-
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
---
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
K
---
N
VPNP
R
---
I
K
L
I
D
F
G
I
-
A
H
K
-
I
---
E
---------------
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
--
E
T
K
Q
-----
E
T
L
T
N
I
S
AV
N
Y
--
D
--
F
D
---
E
--
E
----
Y
-
F
--
S
N
-------
T
S
EL-----
A
K
D
F
----
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
T
I
A
Q
S
L
E
H
S
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
188
Blastp_CBE
44.86
37%
22
- C2 -
-
3I7B
5.8
-
?
A:
[23-287]
----------------------------------
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
----
Q
E
C
A
V
K
V
--
I
S
K
R
--
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
-
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
--
A
N
E
Y
-----
D
I
L
K
K
V
E
--
K
G
KY
T
--
F
E
---
L
--
P
----
Q
-
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
258
Blastp_CBE
44.81
38%
24
- C2 -
-
2XUU
5.3
-
DAPK1_HUMAN
A:
[19-274]
---------------------------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
----
L
Q
Y
A
A
K
F
--
I
K
K
R
--
R
-
T
-
K
-----
S
S
RRGV
S
-
R
---
E
D
I
E
---
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
---
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
-
A
H
K
-
I
---
D
F
-
G
--
N
-
E
--
F
K
N
I
-
F
G
T
P
A
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
--
D
T
K
Q
-----
E
T
L
A
N
V
S
--
A
V
--
N
--
Y
E
---
F
--
E
----
D
-
E
--
Y
F
-------
S
N
-------
T
S
A
L
AKDF
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
269
Blastp_CBE
44.73
36%
31
- C2 -
-
5A6O
3.1
-
DAPK3_HUMAN
B:
[7-268]
---------------------------------------
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
----
K
E
Y
A
A
K
F
--
I
K
K
R
--
R
-
L
-
S
-----
S
S
RRGV
S
-
R
---
E
E
I
E
---
R
E
V
N
I
L
R
E
I
R
-
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
---
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
K
---
N
VPNP
R
---
I
K
L
I
D
F
G
I
-
A
H
K
-
I
---
E
-----------
K
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
--
E
T
K
Q
-----
E
T
L
T
N
I
S
AV
N
Y
--
D
--
F
D
---
E
--
E
----
Y
-
F
--
S
N
-------
T
S
EL-----
A
K
D
F
----
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
T
I
A
Q
S
L
E
H
S
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
263
Blastp_CBE
44.73
35%
-42
- C2 -
-
3COK
5.1
-
PLK4_HUMAN
B:
[10-265]
------------------------------------
I
E
D
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
----
L
E
V
A
I
K
M
--
I
D
K
K
--
A
-
M
-
Y
-----
K
A
G---
M
-
V
---
Q
R
V
Q
---
N
E
V
K
I
H
C
Q
L
K
-
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
--
K
N
R
V
K
P
FSE
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
I
L
H
R
D
L
T
L
S
N
L
L
---
L
---
T
R
N
---
M
----
N
---
I
K
I
A
D
F
G
L
-
A
-
T
Q
L
---
K
-----------------------------------------
L
E
-----
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
---------------
N
T
L
N
K
V
V
--
L
A
--
D
--
Y
E
---
M
--
P
----
S
-
F
--
L
S
-------
I
E
-------
A
K
D
L
----
I
H
Q
L
L
R
R
N
P
A
D
R
L
-----
S
L
S
S
V
L
D
H
P
------
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
246
Blastp_CBE
44.65
38%
26
- C2 -
-
5AV0
5.1
-
DAPK1_HUMAN
A:
[19-274]
---------------------------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
----
L
Q
Y
A
A
K
F
--
I
K
K
R
--
R
-
T
-
K
-----
S
S
RRGV
S
-
R
---
E
D
I
E
---
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-
S
L
T
E
---
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
-
A
H
K
-
I
---
D
F
-
G
--
N
-
E
--
F
K
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
--
D
T
K
Q
-----
E
T
L
A
N
V
S
--
A
V
--
N
--
Y
E
---
F
--
E
----
D
-
E
--
Y
F
-------
S
N
-------
T
S
A
L
AKDF
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
175
Blastp_CBE
44.64
37%
12
- C2 -
-
4ONA
5.6
-
?
A:
[20-284]
-------------------------------ST
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
----
Q
E
C
A
V
K
V
--
I
S
K
R
--
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
-
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
--
A
N
E
Y
-----
D
I
L
K
K
V
E
--
K
G
KY
T
--
F
E
---
L
--
P
----
Q
-
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
428
Blastp_CBE
44.62
34%
-7
- C2 -
-
5D9L
4.6
-
KS6A3_HUMAN
A:
[32-314]
---------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
-
V
K
K
I
S
G
SDAR
Q
L
Y
A
M
K
V
--
L
K
K
A
TL
K
-
V
-
R
-----
D
R
----
V
-
R
---
T
K
M
E
---
R
D
I
L
V
E
--
V
N
-
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
---
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
---
L
---
D
E
E
---
G
----
H
---
I
K
L
T
D
F
G
L
-
S
-
K
-
E
--------------------
G
T
V
E
Y
M
A
P
E
V
V
---
N
R
R
G
H
-----
T
Q
S
-----
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
--
G
--
K
D
R
K
-----
E
T
M
T
M
I
L
--
K
A
--
K
--
L
G
---
M
--
P
----
Q
-
F
--
L
S
-------
P
E
-------
A
Q
S
L
----
L
R
M
L
F
K
R
N
P
A
N
R
L
GAGPD
G
V
E
E
I
K
R
H
S
FFSTID
W
---
N
--------
K
L
Y
R
--
R
E
I
H
---
P
P
F
K
P
A
T
G
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
179
Blastp_CBE
44.61
37%
16
- C2 -
-
3V5P
5.9
-
?
A:
[20-299]
-------------------------------ST
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
----
Q
E
C
A
V
K
V
--
I
S
K
R
--
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
-
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
--
A
N
E
Y
-----
D
I
L
K
K
V
E
--
K
G
KY
T
--
F
E
---
L
--
P
----
Q
-
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
166
Blastp_CBE
44.59
37%
20
- C2 -
-
5W9E
5.6
-
?
A:
[21-297]
-------------------------------T-
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
----
Q
E
C
A
V
K
V
--
I
S
K
R
--
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
-
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
--
A
N
E
Y
-----
D
I
L
K
K
V
E
--
K
G
KY
T
--
F
E
---
L
--
P
----
Q
-
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
167
Blastp_CBE
44.47
37%
15
- C2 -
-
5W91
6.0
-
?
A:
[20-298]
-------------------------------ST
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
----
Q
E
C
A
V
K
V
--
I
S
K
R
--
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
-
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
--
A
N
E
Y
-----
D
I
L
K
K
V
E
--
K
G
KY
T
--
F
E
---
L
--
P
----
Q
-
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
185
Blastp_CBE
44.44
37%
26
- C2 -
-
3SXF
5.4
-
?
A:
[22-295]
---------------------------------
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
----
Q
E
C
A
V
K
V
--
I
S
K
R
--
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
-
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
--
A
N
E
Y
-----
D
I
L
K
K
V
E
--
K
G
KY
T
--
F
E
---
L
--
P
----
Q
-
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
153
Blastp_CBE
44.39
37%
22
- C2 -
-
4IHP
5.0
-
?
A:
[44-317]
-------------------------------T-
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
----
Q
E
C
A
V
K
V
--
I
S
K
R
--
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
-
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
--
A
N
E
Y
-----
D
I
L
K
K
V
E
--
K
G
KY
T
--
F
E
---
L
--
P
----
Q
-
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
173
Blastp_CBE
44.36
37%
16
- C2 -
-
4WG3
5.3
-
?
A:
[20-289]
-------------------------------ST
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
----
Q
E
C
A
V
K
V
--
I
S
K
R
--
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
-
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
--
A
N
E
Y
-----
D
I
L
K
K
V
E
--
K
G
KY
T
--
F
E
---
L
--
P
----
Q
-
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
187
Blastp_CBE
44.31
37%
26
- C2 -
-
3N51
5.5
-
?
A:
[22-299]
---------------------------------
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
----
Q
E
C
A
V
K
V
--
I
S
K
R
--
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
-
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
--
A
N
E
Y
-----
D
I
L
K
K
V
E
--
K
G
KY
T
--
F
E
---
L
--
P
----
Q
-
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
168
Blastp_CBE
44.29
37%
22
- C2 -
-
5W8R
6.8
-
?
A:
[21-292]
-------------------------------T-
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
----
Q
E
C
A
V
K
V
--
I
S
K
R
--
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
-
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
--
A
N
E
Y
-----
D
I
L
K
K
V
E
--
K
G
KY
T
--
F
E
---
L
--
P
----
Q
-
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
195
Blastp_CBE
44.28
36%
22
- C2 -
-
4MXA
5.1
-
?
A:
[21-291]
-------------------------------ST
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
----
Q
E
C
A
V
K
V
--
I
S
K
R
--
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
Y
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
-
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
--
A
N
E
Y
-----
D
I
L
K
K
V
E
--
K
G
KY
T
--
F
E
---
L
--
P
----
Q
-
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
230
Blastp_CBE
44.25
38%
25
- C2 -
-
6QN4
2.5
-
DAPK1_HUMAN
A:
[22-277]
---------------------------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
----
L
Q
Y
A
A
K
F
--
I
K
K
R
--
R
-
T
-
K
-----
S
S
RRGV
S
-
R
---
E
D
I
E
---
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
---
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
-
A
H
K
-
I
---
D
F
-
G
--
N
-
E
--
F
K
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
--
D
T
K
Q
-----
E
T
L
A
N
V
S
--
A
V
--
N
--
Y
E
---
F
--
E
----
D
-
E
--
Y
F
-------
S
N
-------
T
S
A
L
AKDF
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
165
Blastp_CBE
44.24
37%
22
- C2 -
-
5W9R
6.4
-
?
A:
[21-303]
-------------------------------T-
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
----
Q
E
C
A
V
K
V
--
I
S
K
R
--
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
-
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
--
A
N
E
Y
-----
D
I
L
K
K
V
E
--
K
G
KY
T
--
F
E
---
L
--
P
----
Q
-
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
181
Blastp_CBE
44.21
37%
22
- C2 -
-
3UPZ
4.4
-
?
A:
[21-290]
-------------------------------T-
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
----
Q
E
C
A
V
K
V
--
I
S
K
R
--
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
-
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
--
A
N
E
Y
-----
D
I
L
K
K
V
E
--
K
G
KY
T
--
F
E
---
L
--
P
----
Q
-
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
436
Blastp_CBE
44.19
35%
-33
- C2 -
-
3KN5
4.3
-
KS6A5_HUMAN
A:
[16-277]
------------------------------------------
D
K
P
L
G
E
G
S
F
S
I
C
R
K
C
V
H
K
K
S
N
----
Q
A
F
A
V
K
I
--
I
S
K
R
--
M
-
E
-
A
-----
N
T
-------------
Q
---
K
E
I
T
A
L
K
L
C
E
G
H
P
N
I
V
K
L
H
E
V
F
H
D
Q
L
H
T
F
L
V
M
E
L
L
N
G
G
E
L
F
E
R
I
K
K
K
K
H
F
S
E
---
T
E
A
S
Y
I
M
R
K
L
V
S
A
V
S
H
M
H
D
V
G
V
V
H
R
D
L
K
P
E
N
L
L
---
F
---
T
D
----------LE-
I
K
I
I
D
F
G
F
-
A
-
R
-
L
---
K
P
-
P
----------------------------
N
G
Y
D
------
E
S
-----
C
D
L
W
S
L
G
V
I
L
Y
T
M
L
S
G
Q
V
P
F
Q
---------CTSAV
E
I
M
K
K
I
K
--
K
G
--
D
--
F
S
---
F
--
E
GEAW
K
-
N
--
V
S
-------
Q
E
-------
A
K
D
L
----
I
Q
G
L
L
T
V
D
P
N
K
R
L
-----
K
M
S
G
L
R
Y
N
E
------
W
---
L
--------
Q
D
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
184
Blastp_CBE
44.18
37%
24
- C2 -
-
3T3U
6.1
-
?
A:
[22-295]
---------------------------------
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
----
Q
E
C
A
V
K
V
--
I
S
K
R
--
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
-
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
--
A
N
E
Y
-----
D
I
L
K
K
V
E
--
K
G
KY
T
--
F
E
---
L
--
P
----
Q
-
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
196
Blastp_CBE
44.17
36%
20
- C2 -
-
4MX9
5.1
-
?
A:
[21-291]
-------------------------------ST
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
----
Q
E
C
A
V
K
V
--
I
S
K
R
--
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
Y
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
-
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
--
A
N
E
Y
-----
D
I
L
K
K
V
E
--
K
G
KY
T
--
F
E
---
L
--
P
----
Q
-
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
164
Blastp_CBE
44.15
37%
21
- C2 -
-
6BFA
4.8
-
?
A:
[21-284]
-------------------------------T-
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
----
Q
E
C
A
V
K
V
--
I
S
K
R
--
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
-
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
--
A
N
E
Y
-----
D
I
L
K
K
V
E
--
K
G
KY
T
--
F
E
---
L
--
P
----
Q
-
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
283
Blastp_CBE
44.11
36%
39
- C2 -
-
4YUQ
5.7
-
?
A:
[12-291]
-------------------
K
L
A
A
T
P
GMFV
Q
H
ST
A
A
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
V
T
G
----
Q
E
Y
A
V
K
V
--
I
S
K
R
--
Q
----------------------
L
L
L
---
K
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
N
K
---
R
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
S
--
T
-
K
K
-
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
--
A
N
E
F
-----
D
I
L
K
K
V
E
--
K
G
KF
T
--
F
D
---
L
--
P
----
Q
-
W
KK
V
S
-------
E
P
-------
A
K
D
L
----
I
R
K
M
L
A
Y
V
P
T
M
R
I
-----
S
A
R
D
A
L
E
H
E
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
282
Blastp_CBE
43.98
36%
36
- C2 -
-
4YUQ
5.8
-
?
B:
[12-291]
-------------------
K
L
A
A
T
P
GMFV
Q
H
ST
A
A
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
V
T
G
----
Q
E
Y
A
V
K
V
--
I
S
K
R
--
Q
-----------------------
L
L
---
K
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
N
K
---
R
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
S
--
T
-
K
K
-
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
--
A
N
E
F
-----
D
I
L
K
K
V
E
--
K
G
KF
T
--
F
D
---
L
--
P
----
Q
-
W
KK
V
S
-------
E
P
-------
A
K
D
L
----
I
R
K
M
L
A
Y
V
P
T
M
R
I
-----
S
A
R
D
A
L
E
H
E
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
171
Blastp_CBE
43.98
37%
21
- C2 -
-
4WG5
6.2
-
?
A:
[21-284]
-------------------------------T-
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
----
Q
E
C
A
V
K
V
--
I
S
K
R
--
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
-
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
--
A
N
E
Y
-----
D
I
L
K
K
V
E
--
K
G
KY
T
--
F
E
---
L
--
P
----
Q
-
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
176
Blastp_CBE
43.94
37%
18
- C2 -
-
4M84
4.2
-
?
A:
[21-284]
-------------------------------T-
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
----
Q
E
C
A
V
K
V
--
I
S
K
R
--
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
-
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
--
A
N
E
Y
-----
D
I
L
K
K
V
E
--
K
G
KY
T
--
F
E
---
L
--
P
----
Q
-
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
182
Blastp_CBE
43.92
37%
25
- C2 -
-
3UPX
6.6
-
?
A:
[21-303]
-------------------------------T-
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
----
Q
E
C
A
V
K
V
--
I
S
K
R
--
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
-
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
--
A
N
E
Y
-----
D
I
L
K
K
V
E
--
K
G
KY
T
--
F
E
---
L
--
P
----
Q
-
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
169
Blastp_CBE
43.90
37%
26
- C2 -
-
5W80
6.7
-
?
A:
[21-295]
-------------------------------T-
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
----
Q
E
C
A
V
K
V
--
I
S
K
R
--
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
-
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
--
A
N
E
Y
-----
D
I
L
K
K
V
E
--
K
G
KY
T
--
F
E
---
L
--
P
----
Q
-
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
271
Blastp_CBE
43.89
36%
34
- C2 -
-
5A6N
2.9
-
DAPK3_HUMAN
B:
[7-268]
---------------------------------------
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
----
K
E
Y
A
A
K
F
--
I
K
K
R
--
R
-
L
-
S
-----
S
S
RRGV
S
-
R
---
E
E
I
E
---
R
E
V
N
I
L
R
E
I
R
-
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
---
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
K
---
N
VPNP
R
---
I
K
L
I
D
F
G
I
-
A
H
K
-
I
---
E
-----------
K
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
--
E
T
K
Q
-----
E
T
L
T
N
I
S
AV
N
Y
--
D
--
F
D
---
E
--
E
----
Y
-
F
--
S
N
-------
T
S
EL-----
A
K
D
F
----
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
T
I
A
Q
S
L
E
H
S
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
270
Blastp_CBE
43.84
36%
35
- C2 -
-
5A6O
2.9
-
DAPK3_HUMAN
A:
[7-268]
---------------------------------------
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
----
K
E
Y
A
A
K
F
--
I
K
K
R
--
R
-
L
-
S
-----
S
S
RRGV
S
-
R
---
E
E
I
E
---
R
E
V
N
I
L
R
E
I
R
-
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
---
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
K
---
N
VPNP
R
---
I
K
L
I
D
F
G
I
-
A
H
K
-
I
---
E
-----------
K
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
--
E
T
K
Q
-----
E
T
L
T
N
I
S
AV
N
Y
--
D
--
F
D
---
E
--
E
----
Y
-
F
--
S
N
-------
T
S
EL-----
A
K
D
F
----
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
T
I
A
Q
S
L
E
H
S
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
272
Blastp_CBE
43.58
36%
35
- C2 -
-
5A6N
3.8
-
DAPK3_HUMAN
A:
[7-268]
---------------------------------------
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
----
K
E
Y
A
A
K
F
--
I
K
K
R
--
R
-
L
-
S
-----
S
S
RRGV
S
-
R
---
E
E
I
E
---
R
E
V
N
I
L
R
E
I
R
-
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
---
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
K
---
N
VPNP
R
---
I
K
L
I
D
F
G
I
-
A
H
K
-
I
---
E
A
-
G
--
N
-
E
--
F
K
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
--
E
T
K
Q
-----
E
T
L
T
N
I
S
AV
N
Y
--
D
--
F
D
---
E
--
E
----
Y
-
F
--
S
N
-------
T
S
EL-----
A
K
D
F
----
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
T
I
A
Q
S
L
E
H
S
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
151
Blastp_CBE
43.47
37%
25
- C2 -
-
5JMS
6.0
-
?
A:
[62-342]
-------------------------------T-
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
----
Q
E
C
A
V
K
V
--
I
S
K
R
--
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
-
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
--
A
N
E
Y
-----
D
I
L
K
K
V
E
--
K
G
KY
T
--
F
E
---
L
--
P
----
Q
-
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
546
Blastp_CBE
43.32
37%
11
- C2 -
-
2XM9
7.5
-
CHK2_HUMAN
A:
[18-283]
---------------------------------------
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
----
K
K
V
A
I
K
I
--
I
S
K
----------------------PA-
L
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
G
-
E
--
T
-
S
L
-
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
--
E
--
H
R
T
Q
V----
S
L
K
D
Q
I
T
--
S
G
--
K
--
Y
------------
N
-
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
147
Blastp_CBE
43.32
37%
21
- C2 -
-
5T6K
3.8
-
?
A:
[62-356]
-------------------------------T-
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
----
Q
E
C
A
V
K
V
--
I
S
K
R
--
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
----
K
K
-
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
--
A
N
E
Y
-----
D
I
L
K
K
V
E
--
K
G
KY
T
--
F
E
---
L
--
P
----
Q
-
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
549
Blastp_CBE
43.30
37%
3
- C2 -
-
2WTJ
4.7
-
CHK2_HUMAN
A:
[18-283]
---------------------------------------
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
----
K
K
V
A
I
K
I
--
I
S
K
----------------------PA-
L
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
--
E
--
T
-
S
L
-
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
--
E
--
H
R
T
Q
V----
S
L
K
D
Q
I
T
--
S
G
--
K
--
Y
------------
N
-
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
542
Blastp_CBE
43.24
37%
5
- C2 -
-
4A9U
6.3
-
CHK2_HUMAN
A:
[18-283]
---------------------------------------
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
----
K
K
V
A
I
K
I
--
I
S
K
----------------------DPA
L
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
-----
T
-
S
L
-
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
--
E
--
H
R
T
Q
V----
S
L
K
D
Q
I
T
--
S
G
--
K
--
Y
------------
N
-
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
163
Blastp_CBE
43.26
37%
23
- C2 -
-
3MA6
4.1
-
?
A:
[29-290]
----------------------------------
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
----
Q
E
C
A
V
K
V
--
I
S
K
R
--
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
----
S
-
K
K
-
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
--
A
N
E
Y
-----
D
I
L
K
K
V
E
--
K
G
KY
T
--
F
E
---
L
--
P
----
Q
-
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
141
Blastp_CBE
43.26
37%
40
- C2 -
-
4IEB
4.6
-
?
A:
[32-308]
----------------
L
H
A
T
P
G
M
F
V
----
Q
H
ST
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
----
Q
E
C
A
V
K
V
--
I
S
K
R
--
Q
-
V
--TDK--
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
M
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
-
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
--
A
N
E
Y
-----
D
I
L
K
K
V
E
--
K
G
KY
T
--
F
E
------
P
----
Q
-
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
286
Blastp_CBE
43.24
36%
33
- C2 -
-
4YSJ
6.6
-
?
B:
[12-290]
-------------------
K
L
A
A
T
P
GMFV
Q
H
ST
A
A
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
V
T
G
----
Q
E
Y
A
V
K
V
--
I
S
K
R
--------------------------
L
L
---
K
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
N
K
---
R
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
S
--
T
-
K
K
-
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
--
A
N
E
F
-----
D
I
L
K
K
V
E
--
K
G
KF
T
--
F
D
---
L
--
P
----
Q
-
W
KK
V
S
-------
E
P
-------
A
K
D
L
----
I
R
K
M
L
A
Y
V
P
T
M
R
I
-----
S
A
R
D
A
L
E
H
E
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
551
Blastp_CBE
42.80
37%
8
- C2 -
-
2WTD
6.8
-
CHK2_HUMAN
A:
[18-283]
---------------------------------------
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
----
K
K
V
A
I
K
I
--
I
S
K
----------------------PA-
L
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
-----
T
-
S
L
-
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
--
E
--
H
R
T
Q
V----
S
L
K
D
Q
I
T
--
S
G
--
K
--
Y
------------
N
-
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
544
Blastp_CBE
42.77
37%
6
- C2 -
-
4A9S
5.5
-
CHK2_HUMAN
A:
[18-283]
---------------------------------------
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
----
K
K
V
A
I
K
I
--
I
S
K
----------------------PA-
L
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
-----
T
-
S
L
-
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
--
E
--
H
R
T
Q
V----
S
L
K
D
Q
I
T
--
S
G
--
K
--
Y
------------
N
-
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
543
Blastp_CBE
42.52
37%
15
- C2 -
-
4A9T
6.3
-
CHK2_HUMAN
A:
[18-283]
---------------------------------------
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
----
K
K
V
A
I
K
I
--
I
S
K
----------------------PA-
L
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
G
-
E
--
T
-
S
L
-
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
--
E
--
H
R
T
Q
V----
S
L
K
D
Q
I
T
--
S
G
--
K
--
Y
------------
N
-
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
394
Blastp_CBE
42.46
34%
-9
- C2 -
-
3ZO2
5.4
-
KAPCA_BOVIN
A:
[33-298]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
----
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
386
Blastp_CBE
42.45
34%
-8
- C2 -
-
2JDS
Error
-
KAPCA_BOVIN
A:
[33-298]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
----
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
550
Blastp_CBE
42.24
37%
8
- C2 -
-
2WTI
6.8
-
CHK2_HUMAN
A:
[18-283]
---------------------------------------
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
----
K
K
V
A
I
K
I
--
I
S
K
----------------------PA-
L
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
--
E
--
T
-
S
L
-
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
--
E
--
H
R
T
Q
V----
S
L
K
D
Q
I
T
--
S
G
--
K
--
Y
------------
N
-
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
545
Blastp_CBE
42.22
37%
10
- C2 -
-
4A9R
4.9
-
CHK2_HUMAN
A:
[18-283]
---------------------------------------
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
----
K
K
V
A
I
K
I
--
I
S
K
----------------------PA-
L
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
G
-
E
--
T
-
S
L
-
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
--
E
--
H
R
T
Q
V----
S
L
K
D
Q
I
T
--
S
G
--
K
--
Y
------------
N
-
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
397
Blastp_CBE
42.17
34%
-8
- C2 -
-
1XH7
4.2
-
KAPCA_BOVIN
A:
[32-297]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
----
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
241
Blastp_CBE
42.04
38%
25
- C2 -
-
6AAR
4.8
-
DAPK1_HUMAN
A:
[19-274]
---------------------------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
----
L
Q
Y
A
A
K
F
--
I
K
K
R
--
R
-
T
-
K
-----
S
S
RRGV
S
-
R
---
E
D
I
E
---
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-------
L
T
E
---
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
-
A
H
K
-
I
---
D
F
-
G
--
N
-
E
--
F
K
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
--
D
T
K
Q
-----
E
T
L
A
N
V
S
--
A
V
--
N
--
Y
E
---
F
--
E
----
D
-
E
--
Y
F
-------
S
N
-------
T
S
A
L
AKDF
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
224
Blastp_CBE
42.01
38%
15
- C2 -
-
3ZXT
5.4
-
DAPK1_HUMAN
B:
[19-274]
---------------------------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
----
L
Q
Y
A
A
K
F
--
I
K
K
R
--
R
-
T
-
K
------
S
RRGV
S
-
R
---
E
D
I
E
---
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
L
T
E
---
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
-
A
H
K
-
I
---
D
-----------------
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
-
L
S
G
A
S
P
F
L
--
G
--
D
T
K
Q
-----
E
T
L
A
N
V
S
--
A
V
--
N
--
Y
E
---
F
--
E
----
D
-
E
--
Y
F
-----------------
S
A
L
AKDF
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
384
Blastp_CBE
41.98
34%
-8
- C2 -
-
3ZO3
5.4
-
KAPCA_BOVIN
A:
[33-298]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
----
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
432
Blastp_CBE
41.90
34%
-9
- C2 -
-
4C36
1.9
-
KAPCA_BOVIN
A:
[33-298]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
Y
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
----
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
383
Blastp_CBE
41.86
34%
-10
- C2 -
-
5VHB
1.3
-
KAPCA_BOVIN
A:
[33-303]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
----
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
433
Blastp_CBE
41.84
34%
-13
- C2 -
-
4C35
4.1
-
KAPCA_BOVIN
A:
[33-298]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
Y
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
----
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
417
Blastp_CBE
41.68
34%
-9
- C2 -
-
4C38
1.4
-
KAPCA_BOVIN
A:
[33-298]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
Y
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
----
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
434
Blastp_CBE
41.65
34%
-9
- C2 -
-
4C34
2.2
-
KAPCA_BOVIN
A:
[33-299]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
Y
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
----
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
418
Blastp_CBE
41.59
34%
-6
- C2 -
-
4C37
1.5
-
KAPCA_BOVIN
A:
[33-298]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
Y
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
----
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
522
Blastp_CBE
41.49
34%
-8
- C2 -
-
4WB8
5.6
-
KAPCA_HUMAN
A:
[20-284]
-----------------------
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
----
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
439
Blastp_CBE
41.47
34%
-7
- C2 -
-
4WB6
4.5
-
KAPCA_HUMAN
A:
[33-297]
-----------------------
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
----
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
T
---
C
G
T
P
E
Y
R
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
552
Blastp_CBE
41.46
37%
13
- C2 -
-
2WTC
6.1
-
CHK2_HUMAN
A:
[18-283]
---------------------------------------
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
----
K
K
V
A
I
K
I
--
I
S
K
----------------------PA-
L
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
-----
T
-
S
L
-
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
--
E
--
H
R
T
Q
V----
S
L
K
D
Q
I
T
--
S
G
--
K
--
Y
------------
N
-
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
385
Blastp_CBE
41.11
34%
-6
- C2 -
-
3ZO1
5.0
-
KAPCA_BOVIN
A:
[33-298]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
----
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
381
Blastp_CBE
41.09
34%
-4
- C2 -
-
1XH4
0.0
-
KAPCA_BOVIN
A:
[32-297]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
----
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
380
Blastp_CBE
41.00
34%
-4
- C2 -
-
3BWJ
3.0
-
KAPCA_BOVIN
A:
[32-297]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
----
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
425
Blastp_CBE
40.81
34%
-9
- C2 -
-
4WB5
5.3
-
KAPCA_HUMAN
A:
[33-297]
-----------------------
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
----
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
379
Blastp_CBE
40.74
34%
-6
- C2 -
-
3KKV
Error
-
KAPCA_BOVIN
A:
[32-297]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
----
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
382
Blastp_CBE
40.57
34%
-7
- C2 -
-
1Q8W
3.0
-
KAPCA_BOVIN
A:
[32-297]
----------------------
N
P
A
----
Q
N
--
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
----
N
H
Y
A
M
K
I
--
L
D
K
Q
--
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
----
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
-
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
--
D
Q
P
I
-----
Q
I
Y
E
K
I
V
--
S
G
--
K
--
V
R
---
F
--
P
----
S
-
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
------
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
223
Blastp_CBE
30.41
38%
15
- C2 -
-
3ZXT
1.3
-
DAPK1_HUMAN
C:
[15-274]
---------------------------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
----
L
Q
Y
A
A
K
F
--
I
K
K
R
--
R
-
T
-
K
-----
S
S
RRGV
S
-
R
---
E
D
I
E
---
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
---
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
-
A
H
K
-
I
---
D
F
-
G
-----------------
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
--
D
T
K
Q
-----
E
T
L
A
N
V
S
--
A
V
--
N
--
Y
E
---
F
--
E
----
D
-
E
--
Y
F
-------
S
N
-------
T
S
A
L
AKDF
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
------
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
:
---------------------------------------------------------------------------------------------------------------------------------------------------------