@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Screening
Virtual Screening Score
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : BRSK2_HUMAN: (2020-09-05 )
MTSTGKDGGAQHAQYVGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDAARRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHSLGCFRDRNKLLQDLLSEEENQEKMIYFLLLDRKERYPSQEDEDLPPRNEIDPPRKRVDSPMLNRHGKRRPERKSMEVLSVTDGGSPVPARRAIEMAQHGQRSRSISGASSGLSTSPLSSPRVTPHPSPRGSPLPTPKGTPVHTPKESPAGTPNPTPPSSPSVGGVPWRARLNSIKNSFLGSPRFHRRKLQVPTPEEMSNLTPESSPELAKKSWFGNFISLEKEEQIFVVIKDKPLSSIKADIVHAFLSIPSLSHSVISQTSFRAEYKATGGPAVFQKPVKFQVDITYTEGGEAQKENGIYSVTFTLLSGPSRRFKRVVETIQAQLLSTHDPPAAQHLSDTTNCMEMMTGRLSKCGSPLSNFFDVIKQLFSDEKNGQAAQAPSTPAKRSAHGPLGDSAAAGPGPGGDAEYPTGKDTAKMGPPTARREQP
Atome Classification :
(423 SA)
.........10.--------.......20........30........40........--50...-.-.-----..----.-60--....---.....70...-.....80........90........100.......110...---....120.......130.......140......---.---150---.----.---.....160-.-.-.---..-.--.-170...-....180.....--..190.-----.--..-----...200.......210......--.220-.......--230-...---.--.----.----.--.240-----..-------....----...250.......-----260.......270......---.280.......290.......300..--.....310.......320.......330.......340.......350.......360.......370-.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(pKd)
(pKd)
(Uniprot)
MTSTGKDGGA
Q
H
--------
A
QYV
G
P
Y
R
L
E
K
T
LGKGQTG
L
V
K
L
G
V
H
C
V
T
C
Q
K
V
A
I
K
I
--
V
N
R
E
K
-
L
-
S
-----
E
S
----
V
-
L
---
M
K
V
E
---
R
E
I
A
I
L
K
L
IE-HP
H
V
L
K
L
H
D
V
YEN
K
K
Y
L
Y
L
V
L
EHVSG
G
E
L
F
D
Y
L
V
KKGRL
T
P
---
K
E
A
R
K
F
F
R
Q
I
I
S
A
L
D
F
C
HSH
S
I
C
HRDLKPE
N
L
L
---L---DEK---N----
N
---
I
R
I
A
DFG
M
-
A
-
S
-
L
---
Q
V
-
G
--
D
-
S
L
L
ETS-CGSPHYA
C
P
E
V
I--RGEKYD-----G--RK-----A
D
V
W
S
C
G
V
I
L
F
A
L
L
VGALPFD
D
--
D
N
L
R
-
Q
L
L
E
K
V
K
--
R
G
--VFH---M--P----H----F--IP-------P
D
-------
C
Q
S
L
----
L
R
G
M
I
E
V
D
A
A
R
R
L
-----
T
L
E
H
I
Q
K
H
I
W
Y
IGGKNEPE---PEQPIP
R
K
V
Q
IRSLPSLEDI
D
P
D
V
L
D
--
S
M
H
SLGC
F
R
D
R
N
K
L
L
Q
D
L
L
S
EEENQ
E
K
M
I
Y
F
L
L
LD
R
K
ERYPSQEDEDLPPRNEIDP
P
R
KRVD
S
P
M
L
N
R-HGKRRPERKS
M
E
V
L
S
VTDGGSPV
P
A
R
R
A
I
E
M
A
Q
HGQRSRSISGASSGLSTSPLSSPRVTPHPSPRGSPLPTPKGTPVHTPKESPAGTPNPTPPSSPSVGG
V
P
W
R
A
R
L
N
S
I
K
N
SFLGSPRF
H
R
R
KLQVP
T
P
E
E
M
SNLTPESS
P
E
L
A
K
K
S
WFGNFISLEKE
E
Q
I
F
V
V
IKDK
P
L
S
S
I
K
A
D
I
V
H
A
F
L
SIP
S
L
S
H
S
V
I
S
QTS
F
R
A
E
YKATGG
P
A
V
FQKP
V
K
F
Q
V
D
I
T
YTEGGEAQKEN
G
I
Y
S
V
T
F
T
LLSG
P
S
R
R
F
K
R
V
V
E
T
I
Q
A
Q
L
LSTHDP
P
A
A
Q
H
L
S
D
T
T
N
C
M
E
M
M
T
G
R
L
S
KCGS
P
L
S
N
F
F
D
V
I
K
Q
L
FSDEKNGQAAQAPSTPAKRSAHGPLGDSAAAGPGPGGDAEYPTGKDTAKMGPPTARREQP
1
PsiBlast_PDB
96.99
99%
-150
- C2 -
-
4YOM
-
-
?
B:
[13-342]
-----------
H
--------
A
Q
Y
V
G
P
Y
R
L
E
K
T
L
G
K
G
Q
T
G
L
V
K
L
G
I
H
C
V
T
C
Q
K
V
A
I
K
I
--
V
N
R
E
K
-
L
-
S
-----
E
S
----
V
-
L
---
M
K
V
E
---
R
E
I
A
I
L
K
L
I
E
-
H
P
H
V
L
K
L
H
D
V
Y
E
N
K
K
Y
L
Y
L
V
L
E
H
V
S
G
G
E
L
F
D
Y
L
V
K
K
G
R
L
T
P
---
K
E
A
R
K
F
F
R
Q
I
I
S
A
L
D
F
C
H
S
H
S
I
C
H
R
D
L
K
P
E
N
L
L
---
L
---
D
E
R
---
N
----
N
---
I
R
I
A
D
F
G
M
-
A
-
S
-
L
---
Q
V
-
G
--
D
-
S
L
L
E
T
S
-
C
G
S
P
H
Y
A
C
P
E
V
I
--
R
G
E
K
Y
D
-----
G
--
R
K
-----
A
D
V
W
S
C
G
V
I
L
F
A
L
L
V
G
A
L
P
F
D
D
--
D
N
L
R
-
Q
L
L
E
K
V
K
--
R
G
--
V
F
H
---
M
--
P
----
H
----
F
--
I
P
-------
P
D
-------
C
Q
S
L
----
L
R
G
M
I
E
V
D
A
A
R
R
L
-----
T
L
E
H
I
Q
K
H
I
W
Y
I
G
G
K
N
-------------
K
V
Q
I
R
S
L
P
S
L
E
D
I
D
P
D
V
L
D
--
S
M
H
S
L
G
C
F
R
D
R
N
K
L
L
Q
D
L
L
S
E
E
E
N
Q
E
K
M
I
Y
F
L
L
L
D
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
75.42
45%
-128
- C2 -
-
3IEC
-
-
MARK2_HUMAN
A:
[5-317]
----------------------
H
I
G
N
Y
R
L
L
K
T
I
G
----
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
--
I
D
K
T
Q
-
L
-
N
-----
S
S
----
S
-
L
---
Q
K
L
F
---
R
E
V
R
I
M
K
V
L
N
-
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
W
M
K
E
---
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
D
---
M
----
N
---
I
K
I
A
D
F
G
F
-
S
-
N
-
E
---
F
T
-
F
--
G
-
N
K
L
D
T
F
-
C
G
S
P
P
Y
A
A
P
E
L
F
--
Q
G
K
K
Y
D
-----
G
--
P
E
-----
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
--
Q
N
L
K
-
E
L
R
E
R
V
L
--
R
G
--
K
Y
R
---
I
--
P
----
F
----
Y
--
M
S
-------
T
D
-------
C
E
N
L
----
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
R
W
M
N
V
G
H
E
D
D
E
---
L
------
K
P
Y
V
E
P
L
P
D
Y
K
--
D
P
R
R
T
E
--
L
M
V
S
M
G
Y
T
R
E
E
---
I
Q
D
S
L
V
G
Q
R
Y
N
E
V
M
A
T
Y
L
L
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
72.69
45%
-124
- C2 -
-
5KZ8
7.5
-
MARK2_HUMAN
A:
[31-345]
----------------------
H
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
--
I
D
K
T
Q
-
L
-
N
-----
S
S
----
S
-
L
---
Q
K
L
F
---
R
E
V
R
I
M
K
V
L
N
-
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
---
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
D
---
M
----
N
---
I
K
I
A
D
F
G
-------------------------
C
G
S
P
P
Y
A
A
P
E
L
F
--
Q
G
K
K
Y
D
-----
G
--
P
E
-----
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
--
Q
N
L
K
-
E
L
R
E
R
V
L
--
R
G
--
K
Y
R
---
I
--
P
----
F
----
Y
--
M
S
-------
T
D
-------
C
E
N
L
----
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
R
W
M
N
V
G
H
E
D
D
E
---
L
------
K
P
Y
V
E
P
L
P
D
Y
K
--
D
P
R
R
T
E
--
L
M
V
S
M
G
Y
T
R
E
E
---
I
Q
D
S
L
V
G
Q
R
Y
N
E
V
M
A
T
Y
L
L
L
G
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
575
HHSearch
72.43
44%
-115
- C2 -
-
2QNJ
-
-
MARK3_HUMAN
B:
[49-367]
-----------
E
--------
Q
P
H
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
R
E
V
A
I
K
I
--
I
D
K
T
Q
-
L
-
N
-----
P
T
----
S
-
L
---
Q
K
L
F
---
R
E
V
R
I
M
K
I
L
N
-
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
I
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
---
K
E
A
R
S
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
R
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
D
---
M
----
N
---
I
K
I
A
D
F
G
F
-
S
-
N
-
E
---
F
T
-------
K
L
D
T
F
-
C
G
S
P
P
Y
A
A
P
E
L
F
--
Q
G
K
K
Y
D
-----
G
--
P
E
-----
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
--
Q
N
L
K
-
E
L
R
E
R
V
L
--
R
G
--
K
Y
R
---
I
--
P
----
F
----
Y
--
M
S
-------
T
D
-------
C
E
N
L
----
L
K
R
F
L
V
L
N
P
I
K
R
G
-----
T
L
E
Q
I
M
K
D
R
W
I
N
A
G
H
E
E
D
E
---
L
-
K
P
F
-------
V
E
P
E
L
D
I
S
D
Q
K
R
I
D
--
I
M
V
G
M
G
Y
--
S
Q
E
E
I
Q
E
S
L
S
K
M
K
Y
D
E
I
T
A
T
Y
L
L
L
G
R
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Blastp_CBE
71.90
45%
-118
- C2 -
-
5EAK
8.0
-
MARK2_HUMAN
B:
[15-327]
------------------------
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
--
I
D
K
T
Q
-
L
-
N
-----
S
S
----
S
-
L
---
Q
K
L
F
---
R
E
V
R
I
M
K
V
L
N
-
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
---
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
D
---
M
----
N
---
I
K
I
A
D
F
G
-----------------------
F
-
C
G
S
P
P
Y
A
A
P
E
L
F
--
Q
G
K
K
Y
D
-----
G
--
P
E
-----
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
--
Q
N
L
K
-
E
L
R
E
R
V
L
--
R
G
--
K
Y
R
---
I
--
P
----
F
----
Y
--
M
S
-------
T
D
-------
C
E
N
L
----
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
R
W
M
N
V
G
H
E
D
D
E
---
L
------
K
P
Y
V
E
P
L
P
D
Y
K
--
D
P
R
R
T
E
--
L
M
V
S
M
G
Y
T
R
E
E
---
I
Q
D
S
L
V
G
Q
R
Y
N
E
V
M
A
T
Y
L
L
L
G
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
71.80
45%
-125
- C2 -
-
5ES1
7.9
-
MARK4_HUMAN
A:
[13-328]
----------------------
H
V
G
N
Y
R
L
L
R
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
R
E
V
A
I
K
I
--
I
D
K
T
Q
-
L
-
N
-----
P
S
----
S
-
L
---
Q
K
L
F
---
R
E
V
R
I
M
K
G
L
N
-
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
A
G
E
V
F
D
Y
L
V
S
H
G
R
M
K
E
---
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
H
Y
C
H
Q
K
N
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
E
---
A
----
N
---
I
K
I
A
D
F
G
F
-
S
-
N
----------------------
S
P
P
Y
A
A
P
E
L
F
--
Q
G
K
K
Y
D
-----
G
--
P
E
-----
V
D
I
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
--
H
N
L
K
-
E
L
R
E
R
V
L
--
R
G
--
K
Y
R
---
V
--
P
----
F
----
Y
--
M
S
-------
T
D
-------
C
E
S
I
----
L
R
R
F
L
V
L
N
P
A
K
R
C
-----
T
L
E
Q
I
M
K
D
K
W
-
I
N
I
G
Y
E
G
E
---
E
L
K
P
Y
T
E
-------
P
E
E
D
F
G
D
T
K
R
I
E
--
V
M
V
G
M
G
Y
T
R
E
E
I
K
--
E
S
L
T
S
Q
K
Y
N
E
V
T
A
T
Y
-
L
L
L
G
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
71.56
45%
-129
- C2 -
-
5KZ7
7.6
-
MARK2_HUMAN
A:
[31-345]
----------------------
H
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
--
I
D
K
T
Q
-
L
-
N
-----
S
S
----
S
-
L
---
Q
K
L
F
---
R
E
V
R
I
M
K
V
L
N
-
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
---
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
D
---
M
----
N
---
I
K
I
A
D
F
---------------------------
G
S
P
P
Y
A
A
P
E
L
F
--
Q
G
K
--
D
-----
G
--
P
E
-----
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
----
N
L
K
-
E
L
R
E
R
V
L
--
R
G
--
K
Y
R
---
I
--
P
----
F
----
Y
--
M
S
-------
T
D
-------
C
E
N
L
----
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
R
W
M
N
V
G
H
E
D
D
E
---
L
------
K
P
Y
V
E
P
L
P
D
Y
K
--
D
P
R
R
T
E
--
L
M
V
S
M
G
Y
T
R
E
E
---
I
Q
D
S
L
V
G
Q
R
Y
N
E
V
M
A
T
Y
L
L
L
G
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Blastp_CBE
71.29
45%
-127
- C2 -
-
5KZ8
7.3
-
MARK2_HUMAN
B:
[31-345]
----------------------
H
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
--
I
D
K
T
Q
-
L
-
N
-----
S
S
----
S
-
L
---
Q
K
L
F
---
R
E
V
R
I
M
K
V
L
N
-
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
---
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
D
---
M
----
N
---
I
K
I
A
D
F
---------------------------
G
S
P
P
Y
A
A
P
E
L
F
--
Q
G
K
K
Y
D
-----
G
--
P
E
-----
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
--
Q
N
L
K
-
E
L
R
E
R
V
L
--
R
G
--
K
Y
R
---
I
--
P
----
F
----
Y
--
M
S
-------
T
D
-------
C
E
N
L
----
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
R
W
M
N
V
G
H
E
D
D
E
---
L
------
K
P
Y
V
E
P
L
P
D
Y
K
--
D
P
R
R
T
E
--
L
M
V
S
M
G
Y
T
R
E
E
---
I
Q
D
S
L
V
G
Q
R
Y
N
E
V
M
A
T
Y
L
L
L
G
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
71.22
45%
-113
- C2 -
-
5EAK
7.5
-
MARK2_HUMAN
A:
[13-326]
----------------------
H
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
--
I
D
K
T
Q
-
L
-
N
-----
S
S
----
S
-
L
---
Q
K
L
F
---
R
E
V
R
I
M
K
V
L
N
-
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
---
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
D
---
M
----
N
---
I
K
I
A
D
F
G
F
-
S
--------------------
F
-
C
G
S
P
P
Y
A
A
P
E
L
F
--
Q
G
K
K
Y
D
-----
G
--
P
E
-----
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
--
Q
N
L
K
-
E
L
R
E
R
V
L
--
R
G
--
K
Y
R
---
I
--
P
----
F
----
Y
--
M
S
-------
T
D
-------
C
E
N
L
----
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
R
W
M
N
V
G
H
E
D
D
E
---
L
------
K
P
Y
V
E
P
L
P
D
Y
K
--
D
P
R
R
T
E
--
L
M
V
S
M
G
Y
T
R
E
E
---
I
Q
D
S
L
V
G
Q
R
Y
N
E
V
M
A
T
Y
L
L
L
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Blastp_CBE
71.08
45%
-127
- C2 -
-
5KZ7
7.2
-
MARK2_HUMAN
B:
[31-345]
----------------------
H
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
--
I
D
K
T
Q
-
L
-
N
-----
S
S
----
S
-
L
---
Q
K
L
F
---
R
E
V
R
I
M
K
V
L
N
-
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
---
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
D
---
M
----
N
---
I
K
I
A
D
F
---------------------------
G
S
P
P
Y
A
A
P
E
L
F
--
Q
G
K
--
D
-----
G
--
P
E
-----
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
----
N
L
K
-
E
L
R
E
R
V
L
--
R
G
--
K
Y
R
---
I
--
P
----
F
----
Y
--
M
S
-------
T
D
-------
C
E
N
L
----
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
R
W
M
N
V
G
H
E
D
D
E
---
L
------
K
P
Y
V
E
P
L
P
D
Y
K
--
D
P
R
R
T
E
--
L
M
V
S
M
G
Y
T
R
E
E
---
I
Q
D
S
L
V
G
Q
R
Y
N
E
V
M
A
T
Y
L
L
L
G
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
70.83
44%
-125
- C2 -
-
1ZMW
-
-
MARK2_RAT
A:
[49-363]
----------------------
H
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
--
I
D
K
T
Q
-
L
-
N
-----
S
S
----
S
-
L
---
Q
K
L
F
---
R
E
V
R
I
M
K
V
L
N
-
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
---
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
D
---
M
----
N
---
I
K
I
A
-----------------------
L
D
A
F
-
C
G
A
P
P
Y
A
A
P
E
L
F
--
Q
G
K
K
Y
D
-----
G
--
P
E
-----
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
--
Q
N
L
K
-
E
L
R
E
R
V
L
--
R
G
--
K
Y
R
---
I
--
P
----
F
----
Y
--
M
S
-------
T
D
-------
C
E
N
L
----
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
R
W
M
N
V
G
H
E
D
D
E
---
L
------
K
P
Y
V
E
P
L
P
D
Y
K
--
D
P
R
R
T
E
--
L
M
V
S
M
G
Y
T
R
E
E
---
I
Q
D
S
L
V
G
Q
R
Y
N
E
V
M
A
T
Y
L
L
L
G
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
69.55
44%
-129
- C2 -
-
1ZMV
-
-
MARK2_RAT
A:
[51-363]
------------------------
G
N
Y
R
L
L
K
T
I
G
K
G
--
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
R
I
--
I
D
K
T
Q
-
L
-
N
-----
S
S
----
S
-
L
---
Q
K
L
F
---
R
E
V
R
I
M
K
V
L
N
-
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
---
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
D
---
M
----
N
---
I
K
I
A
-----------------------------
G
S
P
P
Y
A
A
P
E
L
F
--
Q
G
K
K
Y
D
-----
G
--
P
E
-----
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
--
Q
N
L
K
-
E
L
R
E
R
V
L
--
R
G
--
K
Y
R
---
I
--
P
----
F
----
Y
--
M
S
-------
T
D
-------
C
E
N
L
----
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
R
W
M
N
V
G
H
E
D
D
E
---
L
------
K
P
Y
V
E
P
L
P
D
Y
K
--
D
P
R
R
T
E
--
L
M
V
S
M
G
Y
T
R
E
E
---
I
Q
D
S
L
V
G
Q
R
Y
N
E
V
M
A
T
Y
L
L
L
G
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
69.20
45%
-124
- C2 -
-
1ZMU
-
-
MARK2_RAT
A:
[51-363]
------------------------
G
N
Y
R
L
L
K
T
I
G
K
G
--
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
--
I
D
K
T
Q
-
L
-
N
-----
S
S
----
S
-
L
---
Q
K
L
F
---
R
E
V
R
I
M
K
V
L
N
-
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
---
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
D
---
M
----
N
---
I
K
I
A
-----------------------------
G
S
P
P
Y
A
A
P
E
L
F
--
Q
G
K
K
Y
D
-----
G
--
P
E
-----
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
--
Q
N
L
K
-
E
L
R
E
R
V
L
--
R
G
--
K
Y
R
---
I
--
P
----
F
----
Y
--
M
S
-------
T
D
-------
C
E
N
L
----
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
R
W
M
N
V
G
H
E
D
D
E
---
L
------
K
P
Y
V
E
P
L
P
D
Y
K
--
D
P
R
R
T
E
--
L
M
V
S
M
G
Y
T
R
E
E
---
I
Q
D
S
L
V
G
Q
R
Y
N
E
V
M
A
T
Y
L
L
L
G
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
69.07
43%
-112
- C- -
-
3FE3
-
-
MARK3_HUMAN
A:
[52-366]
----------------------
H
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
R
E
V
A
I
K
I
--
I
D
K
T
Q
-
L
-
N
-----
P
T
----
S
-
L
---
Q
K
L
F
---
R
E
V
R
I
M
K
I
L
N
-
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
I
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
---
K
E
A
R
S
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
R
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
D
---
M
----
N
---
I
K
I
A
D
F
G
F
-
S
-
N
-
E
---
F
T
-
V
--
G
-
G
K
L
D
A
F
-
C
G
A
P
P
Y
A
A
P
E
L
F
--
Q
G
K
K
Y
D
-----
G
--
P
E
-----
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
--
Q
N
L
K
-
E
L
R
E
R
V
L
--
R
G
--
K
Y
R
---
I
--
P
----
F
----
Y
--
M
S
-------
T
D
-------
C
E
N
L
----
L
K
R
F
L
V
L
N
P
I
K
R
G
-----
T
L
E
Q
I
M
K
D
R
W
I
N
A
G
H
E
E
D
E
---
L
K
P
F
V
E
--------
P
E
L
D
I
S
D
Q
K
R
I
D
--
I
M
V
G
M
G
Y
S
Q
E
E
---
I
Q
E
S
L
S
K
M
K
Y
D
E
I
T
A
T
Y
L
L
L
G
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
572
HHSearch
68.53
44%
-111
- C- -
-
3FE3
-
-
MARK3_HUMAN
B:
[50-366]
--------------------
Q
P
H
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
R
E
V
A
I
K
I
--
I
D
K
T
Q
-
L
-
N
-----
P
T
----
S
-
L
---
Q
K
L
F
---
R
E
V
R
I
M
K
I
L
N
-
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
I
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
---
K
E
A
R
S
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
R
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
D
---
M
----
N
---
I
K
I
A
D
F
G
F
-
S
-
N
-
E
---
F
T
-
V
--
G
-
G
K
L
D
A
F
-
C
G
A
P
P
Y
A
A
P
E
L
F
--
Q
G
K
K
Y
D
-----
G
--
P
E
-----
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
--
Q
N
L
K
-
E
L
R
E
R
V
L
--
R
G
--
K
Y
R
---
I
--
P
----
F
----
Y
--
M
S
-------
T
D
-------
C
E
N
L
----
L
K
R
F
L
V
L
N
P
I
K
R
G
-----
T
L
E
Q
I
M
K
D
R
W
I
N
A
G
H
E
E
D
E
---
L
K
-
P
-------
F
V
E
P
E
L
D
I
S
D
Q
K
R
I
D
--
I
M
V
G
M
G
Y
S
--
Q
E
E
I
Q
E
S
L
S
K
M
K
Y
D
E
I
T
A
T
Y
L
L
L
G
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
68.14
45%
-124
- C- -
-
2R0I
-
-
MARK2_RAT
A:
[49-363]
----------------------
H
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
--
I
D
K
T
Q
-
L
-
N
-----
S
S
----
S
-
L
---
Q
K
L
F
---
R
E
V
R
I
M
K
V
L
N
-
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
---
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
D
---
M
----
N
---
I
K
I
A
D
F
---------------------------
G
S
P
P
Y
A
A
P
E
L
F
--
Q
G
K
K
Y
D
-----
G
--
P
E
-----
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
--
Q
N
L
K
-
E
L
R
E
R
V
L
--
R
G
--
K
Y
R
---
I
--
P
----
F
----
Y
--
M
S
-------
T
D
-------
C
E
N
L
----
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
R
W
M
N
V
G
H
E
D
D
E
---
L
------
K
P
Y
V
A
P
L
P
D
Y
K
--
D
P
R
R
T
E
--
L
M
V
S
M
G
Y
T
R
E
E
---
I
Q
D
S
L
V
G
Q
R
Y
N
E
V
M
A
T
Y
L
L
L
G
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
Blastp_CBE
67.20
41%
-135
- C2 -
-
5TVT
8.1
-
MELK_HUMAN
A:
[1-275]
-------
G
S
K
D
Y
--------
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
--
M
D
K
N
T
-
L
-
G
------
S
----
D
-
L
---
P
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
-
C
-
A
-
K
-------------------
G
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
S
Y
L
-----
G
--
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
--
D
N
V
M
-
A
L
Y
K
K
I
M
--
R
G
--
K
Y
D
---
V
--
P
----
K
----
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
---
E
W
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
Blastp_CBE
67.01
41%
-135
- C2 -
-
5TWL
7.3
-
MELK_HUMAN
A:
[1-275]
-------
G
S
K
D
Y
--------
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
--
M
D
K
N
T
-
L
-
G
------
S
----
D
-
L
---
P
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
------------------------
C
G
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
S
Y
L
-----
G
--
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
--
D
N
V
M
-
A
L
Y
K
K
I
M
--
R
G
--
K
Y
D
---
V
--
P
----
K
----
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
---
E
W
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
576
HHSearch
66.90
41%
-143
- C2 -
-
5TVT
8.1
-
MELK_HUMAN
A:
[3-269]
---------
K
D
Y
--------
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
--
M
D
K
N
T
-
L
-
G
------
S
----
D
-
L
---
P
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
-
C
-
A
-
K
-------------------
G
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
S
Y
L
-----
G
--
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
--
D
N
V
M
-
A
L
Y
K
K
I
M
--
R
G
--
K
Y
D
---
V
--
P
----
K
----
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
Blastp_CBE
66.82
39%
-136
- C2 -
-
4CQG
9.0
-
MELK_MOUSE
A:
[11-306]
--------------------------
Y
E
L
Y
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
V
L
T
G
E
M
V
A
I
K
I
--
M
D
K
N
A
-
L
-
G
------
S
----
D
-
L
---
P
R
V
K
---
T
E
I
D
A
L
K
S
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
K
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
L
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
N
---
H
----
K
---
L
K
L
I
D
F
G
L
-
C
-
A
-
K
------------------
C
G
S
L
A
Y
A
A
P
E
L
I
--
Q
----------
G
--
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
--
D
N
V
M
-
A
L
Y
K
K
I
M
--
R
G
--
K
Y
E
---
V
--
P
----
K
----
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
R
N
L
L
N
H
P
W
V
M
Q
D
Y
S
C
P
------------
V
E
W
Q
S
K
T
P
L
T
H
L
D
E
D
C
V
T
EL
S
V
H
H
----
R
S
S
R
Q
T
M
E
D
L
I
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
Blastp_CBE
66.76
39%
-135
- C2 -
-
4BFM
5.9
-
MELK_MOUSE
A:
[11-306]
--------------------------
Y
E
L
Y
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
V
L
T
G
E
M
V
A
I
K
I
--
M
D
K
N
A
-
L
-
G
------
S
----
D
-
L
---
P
R
V
K
---
T
E
I
D
A
L
K
S
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
K
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
L
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
N
---
H
----
K
---
L
K
L
I
D
F
G
L
-
C
-
A
-
K
------------------
C
G
S
L
A
Y
A
A
P
E
L
I
--
Q
----------
G
--
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
--
D
N
V
M
-
A
L
Y
K
K
I
M
--
R
G
--
K
Y
E
---
V
--
P
----
K
----
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
R
N
L
L
N
H
P
W
V
M
Q
D
Y
S
C
P
------------
V
E
W
Q
S
K
T
P
L
T
H
L
D
E
D
C
V
T
EL
S
V
H
H
----
R
S
S
R
Q
T
M
E
D
L
I
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
Blastp_CBE
66.30
42%
-149
- C2 -
-
4UMQ
5.8
-
MELK_HUMAN
A:
[31-294]
--------------------------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
--
M
D
K
N
T
-
L
-
G
------
S
----
D
-
L
---
P
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
------------------------
C
G
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
S
Y
L
-----
G
--
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
--
D
T
A
A
-
A
L
V
A
K
I
M
--
R
G
--
K
Y
D
---
V
--
P
----
K
----
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
---
E
W
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
Blastp_CBE
66.25
42%
-154
- C2 -
-
4UMR
5.3
-
MELK_HUMAN
A:
[31-294]
--------------------------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
--
M
D
K
N
T
-
L
-
G
------
S
----
D
-
L
---
P
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
------------------------
C
G
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
S
Y
L
-----
G
--
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
--
D
T
A
A
-
A
L
V
A
K
I
M
--
R
G
--
K
Y
D
---
V
--
P
----
K
----
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
---
E
W
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
Blastp_CBE
66.17
42%
-151
- C2 -
-
5IHC
5.8
-
MELK_HUMAN
A:
[10-273]
--------------------------
Y
E
L
H
E
T
I
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
--
M
D
K
N
T
-
L
-
G
------
S
----
D
-
L
---
P
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
---------------------------
G
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
S
Y
L
-----
G
--
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
--
D
N
V
M
-
A
L
Y
K
K
I
M
--
R
G
--
K
Y
D
---
V
--
P
----
K
----
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
---
E
W
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
Blastp_CBE
66.08
42%
-148
- C2 -
-
4UMT
9.5
-
MELK_HUMAN
A:
[31-294]
--------------------------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
--
M
D
K
N
T
-
L
-
G
------
S
----
D
-
L
---
P
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
------------------------
C
G
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
S
Y
L
-----
G
--
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
--
D
T
A
A
-
A
L
V
A
K
I
M
--
R
G
--
K
Y
D
---
V
--
P
----
K
----
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
---
E
W
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
Blastp_CBE
65.85
42%
-146
- C2 -
-
5IH8
5.7
-
MELK_HUMAN
A:
[10-273]
--------------------------
Y
E
L
H
E
T
I
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
--
M
D
K
N
T
---------------
D
-
L
---
P
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
-
C
-
A
-
K
--------------------
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
S
Y
L
-----
G
--
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
--
D
N
V
M
-
A
L
Y
K
K
I
M
--
R
G
--
K
Y
D
---
V
--
P
----
K
----
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
---
E
W
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
Blastp_CBE
65.78
42%
-150
- C2 -
-
5MAI
7.1
-
MELK_HUMAN
A:
[12-277]
--------------------------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
--
M
D
K
N
T
-
L
-
G
------
S
----
D
-
L
---
P
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
----------------------------
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
S
Y
L
-----
G
--
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
--
D
N
V
M
-
A
L
Y
K
K
I
M
--
R
G
--
K
Y
D
---
V
--
P
----
K
----
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
---
E
W
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
Blastp_CBE
65.74
42%
-137
- C2 -
-
5K00
11.7
-
MELK_HUMAN
A:
[10-273]
--------------------------
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
--
M
D
K
N
T
-
L
-
G
------
S
----
D
-
L
---
P
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
-
C
-
A
-
K
---
P
----------------
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
S
Y
L
-----
G
--
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
--
D
N
V
M
-
A
L
Y
K
K
I
M
--
R
G
--
K
Y
D
---
V
--
P
----
K
----
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
---
E
W
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
Blastp_CBE
65.63
42%
-145
- C2 -
-
4UMU
9.1
-
MELK_HUMAN
A:
[31-294]
--------------------------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
--
M
D
K
N
T
-
L
-
G
------
S
----
D
-
L
---
P
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
------------------------
C
G
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
S
Y
L
-----
G
--
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
--
D
T
A
A
-
A
L
V
A
K
I
M
--
R
G
--
K
Y
D
---
V
--
P
----
K
----
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
---
E
W
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
577
HHSearch
65.62
42%
-146
- C2 -
-
5K00
11.7
-
MELK_HUMAN
A:
[5-267]
---------------------
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
--
M
D
K
N
T
-
L
-
G
------
S
----
D
-
L
---
P
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
-
C
-
A
-
K
---
P
----------------
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
S
Y
L
-----
G
--
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
--
D
N
V
M
-
A
L
Y
K
K
I
M
--
R
G
--
K
Y
D
---
V
--
P
----
K
----
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
Blastp_CBE
65.31
42%
-152
- C2 -
-
4BKZ
4.9
-
MELK_HUMAN
A:
[12-275]
--------------------------
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
--
M
D
K
N
T
-
L
---------------
L
---
P
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
-
C
-
A
----------------------
S
L
A
Y
A
A
P
E
L
I
--
Q
G
---------
G
--
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
--
D
N
V
M
-
A
L
Y
K
K
I
M
--
R
G
--
K
Y
D
---
V
--
P
----
K
----
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
---
E
W
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
Blastp_CBE
65.03
42%
-145
- C2 -
-
5MAH
5.8
-
MELK_HUMAN
A:
[12-275]
--------------------------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
--
M
D
K
N
T
-
L
-
G
------
S
----
D
-
L
---
P
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
-
C
-
A
-
K
--------------------
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
--
L
-----
G
--
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
--
D
N
V
M
-
A
L
Y
K
K
I
M
--
R
G
--
K
Y
D
---
V
--
P
----
K
----
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
---
E
W
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
Blastp_CBE
64.96
42%
-138
- C2 -
-
5IH9
6.2
-
MELK_HUMAN
A:
[10-273]
--------------------------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
--
M
D
K
N
T
-----------------
L
---
P
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
-
C
-
A
-
K
--------------------
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
S
Y
L
-----
G
--
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
--
D
N
V
M
-
A
L
Y
K
K
I
M
--
R
G
--
K
Y
D
---
V
--
P
----
K
----
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
---
E
W
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
Blastp_CBE
64.89
42%
-145
- C2 -
-
4BL1
5.6
-
MELK_HUMAN
A:
[12-275]
--------------------------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
--
M
D
K
N
T
-
L
---------------
L
---
P
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
-
C
-
A
-
K
--------------------
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
--------
G
--
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
--
D
N
V
M
-
A
L
Y
K
K
I
M
--
R
G
--
K
Y
D
---
V
--
P
----
K
----
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
---
E
W
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
Blastp_CBE
64.88
42%
-144
- C2 -
-
4BKY
7.0
-
MELK_HUMAN
A:
[12-275]
--------------------------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
--
M
D
K
N
T
-
L
-------------
D
-
L
---
P
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
-
C
-
A
----------------------
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
--------
G
--
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
--
D
N
V
M
-
A
L
Y
K
K
I
M
--
R
G
--
K
Y
D
---
V
--
P
----
K
----
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
---
E
W
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
Blastp_CBE
64.82
42%
-145
- C2 -
-
5IHA
6.2
-
MELK_HUMAN
A:
[10-273]
--------------------------
Y
E
L
H
E
T
I
G
----
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
--
M
D
K
N
T
-
L
--------------------
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
-
C
-
A
-
K
--------------------
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
S
Y
L
-----
G
--
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
--
D
N
V
M
-
A
L
Y
K
K
I
M
--
R
G
--
K
Y
D
---
V
--
P
----
K
----
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
---
E
W
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
Blastp_CBE
64.80
41%
-148
- C2 -
-
5TWZ
4.9
-
MELK_HUMAN
A:
[2-275]
--------
S
K
D
Y
--------
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
--
M
D
K
N
T
-
L
-
G
------
S
----
D
-
L
---
P
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
--------------------------
G
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
S
Y
L
-----
G
--
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
--
D
N
V
M
-
A
L
Y
K
K
I
M
--
R
G
--
K
Y
D
---
V
--
P
----
K
----
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
---
E
W
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
Blastp_CBE
64.77
41%
-148
- C2 -
-
5TWY
5.8
-
MELK_HUMAN
A:
[1-275]
-------
G
S
K
D
Y
--------
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
--
M
D
K
N
T
---------------
D
-
L
---
P
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
------------------------
C
G
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
--------
G
--
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
--
D
N
V
M
-
A
L
Y
K
K
I
M
--
R
G
--
K
Y
D
---
V
--
P
----
K
----
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
---
E
W
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
Blastp_CBE
64.47
41%
-146
- C2 -
-
5TWY
5.8
-
MELK_HUMAN
B:
[1-275]
-------
G
S
K
D
Y
--------
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
--
M
D
K
N
----------------
D
-
L
---
P
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
-
C
-------------------------
L
A
Y
A
A
P
E
L
I
--
Q
G
K
--------
G
--
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
--
D
N
V
M
-
A
L
Y
K
K
I
M
--
R
G
--
K
Y
D
---
V
--
P
----
K
----
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
---
E
W
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
Blastp_CBE
64.43
42%
-143
- C2 -
-
5M5A
8.2
-
MELK_HUMAN
A:
[12-275]
--------------------------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
--
M
D
K
N
T
-
L
-
G
------
S
----
D
-
L
---
P
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
-
C
-
A
----------------------
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
--
L
-----
G
--
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
--
D
N
V
M
-
A
L
Y
K
K
I
M
--
R
G
--
K
Y
D
---
V
--
P
----
K
----
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
---
E
W
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
Blastp_CBE
64.19
42%
-157
- C2 -
-
5TX3
6.7
-
MELK_HUMAN
A:
[15-278]
--------------------------
Y
E
L
H
E
T
I
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
--
M
D
K
N
------------------------
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
-------------------------
G
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
--------
G
--
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
--
D
N
V
M
-
A
L
Y
K
K
I
M
--
R
G
--
K
Y
D
---
V
--
P
----
K
----
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
---
E
W
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
Blastp_CBE
64.14
42%
-134
- C2 -
-
6GVX
6.4
-
MELK_HUMAN
B:
[15-278]
--------------------------
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
--
M
D
K
N
T
----------
S
----
D
-
L
---
P
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
-
C
-
A
-
K
---
P
---------------
G
S
L
A
Y
A
A
P
E
L
I
--
Q
G
---------
G
--
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
--
D
N
V
M
-
A
L
Y
K
K
I
M
--
R
G
--
K
Y
D
---
V
--
P
----
K
----
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
---
E
W
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
Blastp_CBE
63.97
42%
-144
- C2 -
-
5MAG
5.9
-
MELK_HUMAN
A:
[12-275]
--------------------------
Y
E
L
H
E
T
I
G
T
G
G
-
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
--
M
D
K
N
T
-
L
-------------
D
-
L
---
P
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
-
C
-
A
-
K
--------------------
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
--
L
-----
G
--
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
--
D
N
V
M
-
A
L
Y
K
K
I
M
--
R
G
--
K
Y
D
---
V
--
P
----
K
----
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
---
E
W
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
Blastp_CBE
63.65
42%
-139
- C2 -
-
5MAF
6.8
-
MELK_HUMAN
A:
[12-275]
--------------------------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
--
M
D
K
N
T
-
L
-------------
D
-
L
---
P
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
-
C
-
A
-
K
--------------------
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
--
L
-----
G
--
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
--
D
N
V
M
-
A
L
Y
K
K
I
M
--
R
G
--
K
Y
D
---
V
--
P
----
K
----
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
---
E
W
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
122
Blastp_CBE
62.78
37%
-89
- C2 -
-
6AYW
5.9
-
KCC2D_HUMAN
B:
[10-272]
---------------------
R
F
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
--
I
N
T
K
K
-
L
-
S
-----
A
R
----
D
-
H
---
Q
K
L
E
---
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
---
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
K
---
S
----
K
GAA
V
K
L
A
D
F
G
L
-
A
-
I
-
E
---
V
Q
-
G
--
D
-
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
--
R
K
D
P
Y
------
G
--
K
P
-----
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
--
E
D
Q
H
-
R
L
Y
Q
Q
I
K
--
A
G
--
A
Y
D
---
F
--
P
SPEW
D
----
T
--
V
T
-------
P
E
-------
A
K
D
L
----
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
L
K
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
62.38
49%
-61
- C2 -
-
6B2E
7.5
-
AAPK2_HUMAN
A:
[26-384]
-----------------------
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
--
L
N
R
Q
K
-
I
R
S
-----
L
D
----
V
-
V
---
G
K
I
K
---
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
---
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
H
---
M
----
N
---
A
K
I
A
D
F
G
L
-
S
-
N
-
M
---
M
S
-
D
--
G
-
E
F
L
R
T
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
G
R
L
Y
A
-----
G
--
P
E
-----
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
--
E
H
V
P
-
T
L
F
K
K
I
R
--
G
G
--
V
F
Y
---
I
--
P
----
E
----
Y
--
L
N
-------
R
S
-------
V
A
T
L
----
L
M
H
M
L
Q
V
D
P
L
K
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
Q
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
Blastp_CBE
62.20
42%
-150
- C2 -
-
5TX3
7.2
-
MELK_HUMAN
B:
[15-278]
--------------------------
Y
E
L
H
E
T
I
G
-----
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
--
M
D
K
--------------------------
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
----------------------------
G
S
L
A
Y
A
A
P
E
L
I
--
Q
G
---
L
-----
G
--
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
--
D
N
V
M
-
A
L
Y
K
K
I
M
--
R
G
--
K
Y
D
---
V
--
P
----
K
----
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
---
E
W
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
124
Blastp_CBE
62.10
37%
-88
- C2 -
-
5VLO
7.7
-
KCC2D_HUMAN
B:
[10-272]
---------------------
R
F
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
--
I
N
T
K
K
-
L
-
S
-----
A
R
----
D
-
H
---
Q
K
L
E
---
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
---
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
K
---
S
----
K
GAA
V
K
L
A
D
F
G
L
-
A
-
I
-
E
---
V
Q
-
G
--
D
-
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
--
R
K
D
P
Y
------
G
--
K
P
-----
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
--
E
D
Q
H
-
R
L
Y
Q
Q
I
K
--
A
G
--
A
Y
D
---
F
--
P
SPEW
D
----
T
--
V
T
-------
P
E
-------
A
K
D
L
----
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
L
K
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
123
Blastp_CBE
62.05
37%
-92
- C2 -
-
6AYW
5.8
-
KCC2D_HUMAN
A:
[10-272]
---------------------
R
F
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
--
I
N
T
K
K
-
L
-
S
-----
A
R
----
D
-
H
---
Q
K
L
E
---
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
---
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
K
---
S
----
K
GAA
V
K
L
A
D
F
G
L
-
A
-
I
-
E
---
V
Q
-
G
--
D
-
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
--
R
K
D
P
Y
------
G
--
K
P
-----
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
--
E
D
Q
H
-
R
L
Y
Q
Q
I
K
--
A
G
--
A
Y
D
---
F
--
P
SPEW
D
----
T
--
V
T
-------
P
E
-------
A
K
D
L
----
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
L
K
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
61.59
41%
-42
- C2 -
-
4REW
8.5
-
AAPK1_HUMAN
A:
[5-433]
-----------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
--
L
N
R
Q
K
-
I
R
S
-----
L
D
----
V
-
V
---
G
K
I
R
---
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
---
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
H
---
M
----
N
---
A
K
I
A
D
F
G
L
-
S
-
N
-
M
---
M
S
-
D
--
G
-
E
F
L
R
T
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
G
R
L
Y
A
-----
G
--
P
E
-----
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
--
D
H
V
P
-
T
L
F
K
K
I
C
--
D
G
--
I
F
Y
---
T
--
P
----
Q
----
Y
--
L
N
-------
P
S
-------
V
I
S
L
----
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
S
I
K
D
I
R
E
H
E
W
F
--
K
Q
D
L
P
K
YLF
P
E
-----------------------------------------------------------
I
D
N
R
R
I
M
N
E
A
K
D
F
Y
L
A
----
T
S
P
P
-----
D
H
H
L
T
R
P
H
P
E
R
V
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
125
Blastp_CBE
61.51
37%
-93
- C2 -
-
5VLO
7.0
-
KCC2D_HUMAN
A:
[10-272]
---------------------
R
F
T
D
E
Y
Q
L
F
E
E
L
G
---
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
--
I
N
T
K
K
-
L
-
S
-----
A
R
----
D
-
H
---
Q
K
L
E
---
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
---
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
K
---
S
----
K
GAA
V
K
L
A
D
F
G
L
-
A
-
I
-
E
---
V
Q
-
G
--
D
-
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
--
R
K
D
P
Y
------
G
--
K
P
-----
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
--
E
D
Q
H
-
R
L
Y
Q
Q
I
K
--
A
G
--
A
Y
D
---
F
--
P
SPEW
D
----
T
--
V
T
-------
P
E
-------
A
K
D
L
----
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
L
K
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Blastp_CBE
60.97
42%
-15
- C2 -
-
4RER
8.7
-
AAPK1_HUMAN
A:
[5-430]
-----------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
--
L
N
R
Q
K
-
I
R
S
-----
L
D
----
V
-
V
---
G
K
I
R
---
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
---
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
H
---
M
----
N
---
A
K
I
A
D
F
G
L
-
S
-
N
-
M
----
M
-
S
--
D
-
G
E
F
L
R
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
G
R
L
Y
A
-----
G
--
P
E
-----
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
--
D
H
V
P
-
T
L
F
K
K
I
C
--
D
G
--
I
F
Y
---
T
--
P
----
Q
----
Y
--
L
N
-------
P
S
-------
V
I
S
L
----
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
S
I
K
D
I
R
E
H
E
W
F
--
K
Q
D
L
P
K
YLF
P
E
D
P
S
Y
S
S
----
D
E
A
L
K
E
V
C
E
K
F
E
C
S
--
E
E
E
V
L
S
C
L
Y
N
R
N
H
--
Q
D
P
L
A
-------
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
F
Y
L
A
----
T
S
P
P
D
----
D
H
H
L
T
R
P
H
P
E
R
V
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
150
Blastp_CBE
60.91
37%
-102
- C2 -
-
3BHH
5.9
-
KCC2B_HUMAN
B:
[6-263]
--------------------------
Y
Q
L
Y
E
D
I
G
K
---
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
--
I
N
T
K
K
-
L
-
S
-----
A
R
----
D
-
H
---
Q
K
L
E
---
R
E
A
R
I
C
R
L
L
K
-
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
---
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
K
---
C
----
K
GAA
V
K
L
A
D
F
G
L
-
A
-
I
-
E
---
V
Q
-
G
--
D
-
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
--
R
K
E
A
Y
------
G
--
K
P
-----
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
--
E
D
Q
H
-
K
L
Y
Q
Q
I
K
--
A
G
--
A
Y
D
---
F
--
P
SPEW
D
----
T
--
V
T
-------
P
E
-------
A
K
N
L
----
I
N
Q
M
L
T
I
N
P
A
K
R
I
-----
T
A
H
E
A
L
K
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
126
Blastp_CBE
60.67
38%
-91
- C2 -
-
2WEL
5.2
-
KCC2D_HUMAN
A:
[6-267]
--------------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
--
I
N
T
K
K
-
L
-
S
-----
A
R
----
D
-
H
---
Q
K
L
E
---
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
---
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
K
---
S
----
K
GAA
V
K
L
A
D
F
G
L
-
A
-
I
-
E
---
V
Q
-
G
--
D
-
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
--
R
K
D
P
Y
------
G
--
K
P
-----
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
--
E
D
Q
H
-
R
L
Y
Q
Q
I
K
--
A
G
--
A
Y
D
---
F
--
P
SPEW
D
----
T
--
V
T
-------
P
E
-------
A
K
D
L
----
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
L
K
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
205
Blastp_CBE
60.66
35%
-91
- C2 -
-
3SOA
3.3
-
KCC2A_HUMAN
A:
[8-270]
---------------------
R
F
T
E
E
Y
Q
L
F
E
E
L
G
K
G
--
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
M
I
--
I
N
T
K
K
-
L
-
S
-----
A
R
----
D
-
H
---
Q
K
L
E
---
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
H
H
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
---
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
N
L
K
P
E
N
L
L
---
L
---
A
S
K
LKG
A
----
A
---
V
K
L
A
D
F
G
L
-
A
-
I
-
E
---
V
E
-
G
--
E
-
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
--
R
K
D
P
Y
------
G
--
K
P
-----
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
--
E
D
Q
H
-
R
L
Y
Q
Q
I
K
--
A
G
--
A
Y
D
---
F
--
P
----
S
PEWD
T
--
V
T
-------
P
E
-------
A
K
D
L
----
I
N
K
M
L
T
I
N
P
S
K
R
I
-----
T
A
A
E
A
L
K
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
127
Blastp_CBE
60.59
38%
-84
- C2 -
-
2VN9
6.4
-
KCC2D_HUMAN
B:
[6-263]
--------------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
--
I
N
T
K
K
-
L
-
S
-----
A
R
----
D
-
H
---
Q
K
L
E
---
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
---
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
K
---
S
----
K
GAA
V
K
L
A
D
F
G
L
-
A
-
I
-
E
---
V
Q
-
G
--
D
-
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
--
R
K
D
P
Y
------
G
--
K
P
-----
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
--
E
D
Q
H
-
R
L
Y
Q
Q
I
K
--
A
G
--
A
Y
D
---
F
--
P
SPEW
D
----
T
--
V
T
-------
P
E
-------
A
K
D
L
----
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
L
K
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
128
Blastp_CBE
60.58
38%
-86
- C2 -
-
2VN9
6.1
-
KCC2D_HUMAN
A:
[6-263]
--------------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
--
I
N
T
K
K
-
L
-
S
-----
A
R
----
D
-
H
---
Q
K
L
E
---
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
---
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
K
---
S
----
K
GAA
V
K
L
A
D
F
G
L
-
A
-
I
-
E
---
V
Q
-
G
--
D
-
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
--
R
K
D
P
Y
------
G
--
K
P
-----
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
--
E
D
Q
H
-
R
L
Y
Q
Q
I
K
--
A
G
--
A
Y
D
---
F
--
P
SPEW
D
----
T
--
V
T
-------
P
E
-------
A
K
D
L
----
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
L
K
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
120
Blastp_CBE
60.58
37%
-88
- C2 -
-
6BAB
6.5
-
KCC2D_MOUSE
B:
[14-272]
-------------------------
E
Y
Q
L
F
E
E
L
G
----
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
--
I
N
T
K
K
-
L
-
S
-----
A
R
----
D
-
H
---
Q
K
L
E
---
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
---
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
K
---
S
----
K
GAA
V
K
L
A
D
F
G
L
-
A
-
I
-
E
---
V
Q
-
G
--
D
-
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
--
R
K
D
P
Y
------
G
--
K
P
-----
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
--
E
D
Q
H
-
R
L
Y
Q
Q
I
K
--
A
G
--
A
Y
D
---
F
--
P
SPEW
D
----
T
--
V
T
-------
P
E
-------
A
K
D
L
----
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
L
K
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
151
Blastp_CBE
60.45
37%
-99
- C2 -
-
3BHH
5.6
-
KCC2B_HUMAN
A:
[6-263]
--------------------------
Y
Q
L
Y
E
D
I
G
----
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
--
I
N
T
K
K
-
L
-
S
-----
A
R
----
D
-
H
---
Q
K
L
E
---
R
E
A
R
I
C
R
L
L
K
-
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
---
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
K
---
C
----
K
GAA
V
K
L
A
D
F
G
L
-
A
-
I
-
E
---
V
Q
-
G
--
D
-
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
--
R
K
E
A
Y
------
G
--
K
P
-----
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
--
E
D
Q
H
-
K
L
Y
Q
Q
I
K
--
A
G
--
A
Y
D
---
F
--
P
SPEW
D
----
T
--
V
T
-------
P
E
-------
A
K
N
L
----
I
N
Q
M
L
T
I
N
P
A
K
R
I
-----
T
A
H
E
A
L
K
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Blastp_CBE
59.86
42%
-16
- C2 -
-
6C9G
9.1
-
AAPK1_HUMAN
A:
[13-493]
-----------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
--
L
N
R
Q
K
-
I
R
S
-----
L
D
----
V
-
V
---
G
K
I
R
---
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
---
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
H
---
M
----
N
---
A
K
I
A
D
F
G
L
-
S
-
N
-
M
----
M
-
S
--
D
-
G
E
F
L
R
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
G
R
L
Y
A
-----
G
--
P
E
-----
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
--
D
H
V
P
-
T
L
F
K
K
I
C
--
D
G
--
I
F
Y
---
T
--
P
----
Q
----
Y
--
L
N
-------
P
S
-------
V
I
S
L
----
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
--
K
Q
D
L
P
K
YLF
P
E
D
P
S
Y
S
S
T
M
I
D
D
E
A
L
K
E
V
C
E
K
F
E
C
S
--
E
E
E
V
L
S
C
L
Y
N
R
N
H
--
Q
D
P
L
A
-------
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
F
Y
L
A
T
----
S
P
P
D
S
F
L
D
D
H
H
L
T
R
P
H
P
E
R
V
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Blastp_CBE
59.82
42%
-6
- C2 -
-
6E4U
9.3
-
AAPK1_RAT
A:
[15-502]
-----------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
--
L
N
R
Q
K
-
I
R
S
-----
L
D
----
V
-
V
---
G
K
I
R
---
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
---
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
H
---
M
----
N
---
A
K
I
A
D
F
G
L
-
S
-
N
-
M
----
M
-
S
--
D
-
G
E
F
L
R
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
G
R
L
Y
A
-----
G
--
P
E
-----
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
--
D
H
V
P
-
T
L
F
K
K
I
C
--
D
G
--
I
F
Y
---
T
--
P
----
Q
----
Y
--
L
N
-------
P
S
-------
V
I
S
L
----
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
--
K
Q
D
L
P
K
YLF
P
E
D
P
S
Y
S
S
T
M
I
D
D
E
A
L
K
E
V
C
E
K
F
E
C
S
--
E
E
E
V
L
S
C
L
Y
N
R
N
H
--
Q
D
P
L
A
-------
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
F
Y
L
A
----
T
S
P
---
F
L
D
D
H
H
L
T
R
P
H
P
E
R
V
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
121
Blastp_CBE
59.80
37%
-84
- C2 -
-
6BAB
7.5
-
KCC2D_MOUSE
A:
[12-272]
-----------------------
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
--
I
N
T
K
K
-
L
-
S
-----
A
R
----
D
-
H
---
Q
K
L
E
---
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
---
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
K
---
S
----
K
GAA
V
K
L
A
D
F
G
L
-
A
-
I
-
E
---
V
Q
-
G
--
D
-
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
--
R
K
D
P
Y
------
G
--
K
P
-----
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
--
E
D
Q
H
-
R
L
Y
Q
Q
I
K
--
A
G
--
A
Y
D
---
F
--
P
SPEW
D
----
T
--
V
T
-------
P
E
-------
A
K
D
L
----
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
L
K
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
Blastp_CBE
59.73
42%
-86
- C2 -
-
6GVX
3.3
-
MELK_HUMAN
A:
[15-285]
--------------------------
Y
E
L
H
E
T
I
G
T
--
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
--
M
D
K
N
T
---------------
D
-
L
---
P
R
I
K
---
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
---
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
-
C
-
A
-
K
---
P
K
-
G
NK---------
C
G
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
--------
G
--
S
E
-----
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
--
D
N
V
M
-
A
L
Y
K
K
I
M
--
R
G
--
K
Y
D
---
V
--
P
----
K
----
W
--
L
S
-------
P
S
-------
S
I
L
L
----
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
---
E
W
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
119
Blastp_CBE
59.51
37%
-83
- C2 -
-
6BAB
8.1
-
KCC2D_MOUSE
C:
[14-272]
-------------------------
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
----
Q
E
Y
A
A
K
I
--
I
N
T
K
K
-
L
-
S
-----
A
R
----
D
-
H
---
Q
K
L
E
---
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
---
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
K
---
S
----
K
GAA
V
K
L
A
D
F
G
L
-
A
-
I
-
E
---
V
Q
-
G
--
D
-
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
--
R
K
D
P
Y
------
G
--
K
P
-----
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
--
E
D
Q
H
-
R
L
Y
Q
Q
I
K
--
A
G
--
A
Y
D
---
F
--
P
SPEW
D
----
T
--
V
T
-------
P
E
-------
A
K
D
L
----
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
L
K
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Blastp_CBE
59.35
42%
-12
- C2 -
-
6C9J
9.1
-
AAPK1_HUMAN
A:
[13-492]
-----------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
--
L
N
R
Q
K
-
I
R
S
-----
L
D
----
V
-
V
---
G
K
I
R
---
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
---
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
H
---
M
----
N
---
A
K
I
A
D
F
G
L
-
S
-
N
-
M
----
M
-
S
--
D
-
G
E
F
L
R
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
G
R
L
Y
A
-----
G
--
P
E
-----
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
--
D
H
V
P
-
T
L
F
K
K
I
C
--
D
G
--
I
F
Y
---
T
--
P
----
Q
----
Y
--
L
N
-------
P
S
-------
V
I
S
L
----
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
--
K
Q
D
L
P
K
YLF
P
E
D
P
S
Y
S
S
T
M
I
D
D
E
A
L
K
E
V
C
E
K
F
E
C
S
--
E
E
E
V
L
S
C
L
Y
N
R
N
H
--
Q
D
P
L
A
-------
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
F
Y
L
A
T
----
S
P
P
D
S
F
L
D
D
H
H
L
T
R
P
H
P
E
R
V
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
Blastp_CBE
59.28
41%
-26
- C2 -
-
4CZT
5.2
-
CIPKN_ARATH
C:
[10-295]
-----------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
--
I
D
K
E
K
V
L
-
K
-----
N
K
----
M
-
I
---
A
Q
I
K
---
R
E
I
S
T
M
K
L
I
K
-
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
L
K
E
---
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
A
N
---
G
----
A
---
L
K
V
S
D
F
G
L
-
S
-
A
-
L
PQ-
Q
V
R
E
--
D
-
G
L
L
H
T
T
-
C
G
T
P
N
Y
V
A
P
E
V
I
--
N
N
K
G
Y
D
-----
G
--
A
K
-----
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
--
S
N
L
T
-
S
L
Y
K
K
I
F
--
K
A
--
E
F
T
---
C
--
P
----
P
----
W
--
F
S
-------
A
S
-------
A
K
K
L
----
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
E
V
I
E
N
E
W
F
K
K
G
Y
K
A
P
K
---
F
E
N
---------
A
D
V
S
L
D
D
V
D
A
I
F
D
D
--
S
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
141
Blastp_CBE
59.16
37%
-85
- C2 -
-
5FG8
4.6
-
KCC2A_DROME
A:
[16-273]
--------------------------
Y
D
I
K
E
E
L
G
K
G
A
F
S
I
V
K
R
C
V
Q
K
S
T
G
F
E
F
A
A
K
I
--
I
N
T
K
K
-
L
-
T
-----
A
R
----
D
-
F
---
Q
K
L
E
---
R
E
A
R
I
C
R
K
L
H
-
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
N
Y
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
F
Y
S
E
---
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
N
G
V
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
K
---
A
----
K
GAA
V
K
L
A
D
F
G
L
-
A
-
I
-
E
---
V
Q
-
G
--
D
H
Q
A
W
F
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
--
K
K
E
P
Y
------
G
--
K
S
-----
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
--
E
D
Q
H
-
R
L
Y
S
Q
I
K
--
A
G
--
A
Y
D
---
Y
--
P
SPEW
D
----
T
--
V
T
-------
P
E
-------
A
K
N
L
----
I
N
Q
M
L
T
V
N
P
N
K
R
I
-----
T
A
A
E
A
L
K
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
Blastp_CBE
59.15
41%
-15
- C2 -
-
4CZT
4.7
-
CIPKN_ARATH
D:
[10-304]
-----------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
--
I
D
K
E
K
V
L
-
K
-----
N
K
----
M
-
I
---
A
Q
I
K
---
R
E
I
S
T
M
K
L
I
K
-
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
L
K
E
---
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
A
N
---
G
----
A
---
L
K
V
S
D
F
G
L
-
S
-
A
-
L
PQ-
Q
V
R
E
--
D
-
G
L
L
H
T
T
-
C
G
T
P
N
Y
V
A
P
E
V
I
--
N
N
K
G
Y
D
-----
G
--
A
K
-----
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
--
S
N
L
T
-
S
L
Y
K
K
I
F
--
K
A
--
E
F
T
---
C
--
P
----
P
----
W
--
F
S
-------
A
S
-------
A
K
K
L
----
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
E
V
I
E
N
E
W
F
K
K
G
Y
K
A
P
K
---
F
E
N
---------
A
D
V
S
L
D
D
V
D
A
I
F
D
D
--
S
----
N
L
V
V
E
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Blastp_CBE
58.80
42%
-13
- C2 -
-
6C9F
9.2
-
AAPK1_HUMAN
A:
[13-493]
-----------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
--
L
N
R
Q
K
-
I
R
S
-----
L
D
----
V
-
V
---
G
K
I
R
---
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
---
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
H
---
M
----
N
---
A
K
I
A
D
F
G
L
-
S
-
N
-
M
----
M
-
S
--
D
-
G
E
F
L
R
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
G
R
L
Y
A
-----
G
--
P
E
-----
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
--
D
H
V
P
-
T
L
F
K
K
I
C
--
D
G
--
I
F
Y
---
T
--
P
----
Q
----
Y
--
L
N
-------
P
S
-------
V
I
S
L
----
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
--
K
Q
D
L
P
K
YLF
P
E
D
P
S
Y
S
S
T
M
I
D
D
E
A
L
K
E
V
C
E
K
F
E
C
S
--
E
E
E
V
L
S
C
L
Y
N
R
N
H
--
Q
D
P
L
A
-------
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
F
Y
L
A
T
----
S
P
P
D
S
F
L
D
D
H
H
L
T
R
P
H
P
E
R
V
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
Blastp_CBE
58.43
41%
-19
- C2 -
-
4CZU
4.8
-
CIPKN_ARATH
D:
[10-304]
-----------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
--
I
D
K
E
K
V
L
-
K
-----
N
K
----
M
-
I
---
A
Q
I
K
---
R
E
I
S
T
M
K
L
I
K
-
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
L
K
E
---
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
A
N
---
G
----
A
---
L
K
V
S
D
F
G
L
-
S
-
A
-
L
PQ-
Q
V
R
E
--
D
-
G
L
L
H
D
T
-
C
G
T
P
N
Y
V
A
P
E
V
I
--
N
N
K
G
Y
D
-----
G
--
A
K
-----
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
--
S
N
L
T
-
S
L
Y
K
K
I
F
--
K
A
--
E
F
T
---
C
--
P
----
P
----
W
--
F
S
-------
A
S
-------
A
K
K
L
----
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
E
V
I
E
N
E
W
F
K
K
G
Y
K
A
P
K
---
F
E
N
---------
A
D
V
S
L
D
D
V
D
A
I
F
D
D
--
S
----
N
L
V
V
E
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
152
Blastp_CBE
58.36
37%
-83
- C2 -
-
5HU3
5.1
-
KCC2A_DROME
A:
[16-273]
--------------------------
Y
D
I
K
E
E
L
G
K
G
A
F
S
I
V
K
R
C
V
Q
K
S
T
G
F
E
F
A
A
K
I
--
I
N
T
K
K
-
L
-
T
-----
A
R
----
D
-
F
---
Q
K
L
E
---
R
E
A
R
I
C
R
K
L
H
-
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
N
Y
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
F
Y
S
E
---
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
N
G
V
V
H
R
N
L
K
P
E
N
L
L
---
L
---
A
S
K
---
A
----
K
GAA
V
K
L
A
D
F
G
L
-
A
-
I
-
E
---
V
Q
-
G
--
D
H
Q
A
W
F
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
--
K
K
E
P
Y
------
G
--
K
S
-----
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
--
E
D
Q
H
-
R
L
Y
S
Q
I
K
--
A
G
--
A
Y
D
---
Y
--
P
SPEW
D
----
T
--
V
T
-------
P
E
-------
A
K
N
L
----
I
N
Q
M
L
T
V
N
P
N
K
R
I
-----
T
A
A
E
A
L
K
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Blastp_CBE
58.33
50%
-63
- C2 -
-
3AQV
8.1
-
AAPK2_HUMAN
A:
[10-265]
-----------------------
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
--
L
N
R
Q
K
-
I
R
S
-----
L
D
----
V
-
V
---
G
K
I
K
---
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
---
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
H
---
M
----
N
---
A
K
I
A
D
F
G
L
-
S
-
N
-
M
---
M
S
-
D
--
G
-
E
F
L
-------
P
N
Y
A
A
P
E
V
I
--
S
G
R
L
Y
A
-----
G
--
P
E
-----
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
--
E
H
V
P
-
T
L
F
K
K
I
R
--
G
G
--
V
F
Y
---
I
--
P
----
E
----
Y
--
L
N
-------
R
S
-------
V
A
T
L
----
L
M
H
M
L
Q
V
D
P
L
K
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
Blastp_CBE
58.08
42%
-6
- C2 -
-
5KQ5
8.9
-
?
A:
[15-503]
-----------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
--
L
N
R
Q
K
-
I
R
S
-----
L
D
----
V
-
V
---
G
K
I
R
---
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
---
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
H
---
M
----
N
---
A
K
I
A
D
F
G
L
-
S
-
N
-
M
----
M
-
S
--
D
-
G
E
F
L
R
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
G
R
L
Y
A
-----
G
--
P
E
-----
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
--
D
H
V
P
-
T
L
F
K
K
I
C
--
D
G
--
I
F
Y
---
T
--
P
----
Q
----
Y
--
L
N
-------
P
S
-------
V
I
S
L
----
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
--
K
Q
D
L
P
K
YLF
P
E
D
P
S
Y
S
S
T
M
I
D
D
E
A
L
K
E
V
C
E
K
F
E
C
S
--
E
E
E
V
L
S
C
L
Y
N
R
N
H
--
Q
D
P
L
A
-------
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
F
Y
L
A
----
T
S
P
P
D
S
F
L
D
D
H
H
L
T
R
P
H
P
E
R
V
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
140
Blastp_CBE
58.01
37%
-80
- C2 -
-
5H9B
5.7
-
KCC2A_DROME
A:
[16-273]
--------------------------
Y
D
I
K
E
E
L
G
K
G
A
F
S
I
V
K
R
C
V
Q
K
S
T
G
F
E
F
A
A
K
I
--
I
N
T
K
K
-
L
-
T
-----
A
R
----
D
-
F
---
Q
K
L
E
---
R
E
A
R
I
C
R
K
L
H
-
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
N
Y
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
F
Y
S
E
---
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
N
G
V
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
K
---
A
----
K
GAA
V
K
L
A
D
F
G
L
-
A
-
I
-
E
---
V
Q
-
G
--
D
H
Q
A
W
F
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
--
K
K
E
P
Y
------
G
--
K
S
-----
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
--
E
D
Q
H
-
R
L
Y
S
Q
I
K
--
A
G
--
A
Y
D
---
Y
--
P
SPEW
D
----
T
--
V
T
-------
P
E
-------
A
K
N
L
----
I
N
Q
M
L
T
V
N
P
N
K
R
I
-----
T
A
A
E
A
L
K
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
Blastp_CBE
57.39
41%
-20
- C2 -
-
4CZT
3.5
-
CIPKN_ARATH
A:
[10-297]
-----------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
--
I
D
K
E
K
V
L
-
K
-----
N
K
----
M
-
I
---
A
Q
I
K
---
R
E
I
S
T
M
K
L
I
K
-
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
L
K
E
---
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
A
N
---
G
----
A
---
L
K
V
S
D
F
G
L
-
S
-
A
-
L
PQ-
Q
V
R
E
--
D
-
G
L
L
H
T
T
-
C
G
T
P
N
Y
V
A
P
E
V
I
--
N
N
K
G
Y
D
-----
G
--
A
K
-----
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
--
S
N
L
T
-
S
L
Y
K
K
I
F
--
K
A
--
E
F
T
---
C
--
P
----
P
----
W
--
F
S
-------
A
S
-------
A
K
K
L
----
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
E
V
I
E
N
E
W
F
K
K
G
Y
K
A
P
K
---
F
E
N
-----------
V
S
L
D
D
V
D
A
I
F
D
D
--
S
G
E
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
200
Blastp_CBE
57.36
33%
-60
- C2 -
-
3NCG
6.7
-
?
A:
[14-351]
--------
L
Y
F
Q
--------
G
T
F
A
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
--
I
N
K
A
S
-
A
-
K
-----
N
K
----
D
-
T
---
S
T
I
L
---
R
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
E
---
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
---
E
S
K
---
E
KDC-
D
---
I
K
I
I
D
F
G
L
-
S
-
T
-
C
---
F
Q
-
Q
--
N
-
T
------
I
G
T
A
Y
Y
I
A
P
E
V
L
--
R
G
-
T
Y
D
--------
E
K
-----
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
--
K
N
E
Y
-
D
I
L
K
R
V
E
--
T
G
KY
A
F
D
---
L
--
P
----
Q
----
W
RT
I
S
-------
D
D
-------
A
K
D
L
----
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
A
T
Q
C
L
E
H
P
W
I
----
Q
K
Y
S
---
S
E
T
P
-----
T
I
S
D
L
P
S
L
E
-------
S
--
A
M
T
N
I
R
Q
F
Q
A
E
K
K
L
A
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
Blastp_CBE
57.16
41%
-23
- C2 -
-
4CZU
5.6
-
CIPKN_ARATH
C:
[10-294]
-----------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
--
I
D
K
E
K
V
L
-
K
-----
N
K
----
M
-
I
---
A
Q
I
K
---
R
E
I
S
T
M
K
L
I
K
-
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
L
K
E
---
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
A
N
---
G
----
A
---
L
K
V
S
D
F
G
L
-
S
-
A
-
L
PQ-
Q
V
R
E
--
D
-
G
L
L
H
D
T
-
C
G
T
P
N
Y
V
A
P
E
V
I
--
N
N
K
G
Y
D
-----
G
--
A
K
-----
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
--
S
N
L
T
-
S
L
Y
K
K
I
F
--
K
A
--
E
F
T
---
C
--
P
----
P
----
W
--
F
S
-------
A
S
-------
A
K
K
L
----
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
E
V
I
E
N
E
W
F
K
K
G
Y
K
A
P
K
---
F
E
N
---------
A
-----
D
V
D
A
I
F
D
D
--
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
Blastp_CBE
57.06
41%
-24
- C2 -
-
4CZU
5.5
-
CIPKN_ARATH
A:
[10-302]
-----------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
--
I
D
K
E
K
V
L
-
K
-----
N
K
----
M
-
I
---
A
Q
I
K
---
R
E
I
S
T
M
K
L
I
K
-
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
L
K
E
---
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
A
N
---
G
----
A
---
L
K
V
S
D
F
G
L
-
S
-
A
-
L
PQ-
Q
V
R
E
--
D
-
G
L
L
H
D
T
-
C
G
T
P
N
Y
V
A
P
E
V
I
--
N
N
K
G
Y
D
-----
G
--
A
K
-----
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
--
S
N
L
T
-
S
L
Y
K
K
I
F
--
K
A
--
E
F
T
---
C
--
P
----
P
----
W
--
F
S
-------
A
S
-------
A
K
K
L
----
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
E
V
I
E
N
E
W
F
K
K
G
Y
K
A
P
K
---
F
E
N
--------------
D
D
V
D
A
I
F
D
D
--
S
G
E
S
K
N
L
V
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
Blastp_CBE
56.98
41%
-27
- C2 -
-
4CZT
4.0
-
CIPKN_ARATH
B:
[10-295]
-----------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
--
I
D
K
E
K
V
L
-
K
-----
N
K
----
M
-
I
---
A
Q
I
K
---
R
E
I
S
T
M
K
L
I
K
-
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
L
K
E
---
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
A
N
---
G
----
A
---
L
K
V
S
D
F
G
L
-
S
-
A
-
L
PQ-
Q
V
R
E
--
D
-
G
L
L
H
T
T
-
C
G
T
P
N
Y
V
A
P
E
V
I
--
N
N
K
G
Y
D
-----
G
--
A
K
-----
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
--
S
N
L
T
-
S
L
Y
K
K
I
F
--
K
A
--
E
F
T
---
C
--
P
----
P
----
W
--
F
S
-------
A
S
-------
A
K
K
L
----
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
E
V
I
E
N
E
W
F
K
K
G
Y
K
A
P
K
---
F
E
---------------
D
D
V
D
A
I
F
D
D
--
S
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
132
Blastp_CBE
56.40
39%
-100
- C2 -
-
4FG7
4.3
-
KCC1A_HUMAN
A:
[20-277]
--------------------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
--
I
A
-------------------------
S
M
E
---
N
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
---
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
---
D
E
D
---
S
----
K
---
I
M
I
S
D
F
G
L
-
S
-
K
-
M
---
E
D
-
P
------------
G
T
P
G
Y
V
A
P
E
V
L
--
A
Q
K
--------
S
--
K
A
-----
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
--
E
N
D
A
-
K
L
F
E
Q
I
L
--
K
A
--
E
Y
E
---
F
DS
P
----
Y
----
W
DD
I
S
-------
D
S
-------
A
K
D
F
----
I
R
H
L
M
E
K
D
P
E
K
R
F
-----
T
C
E
Q
A
L
Q
H
P
W
I
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Blastp_CBE
56.24
50%
-71
- C2 -
-
6BX6
5.2
-
AAPK2_HUMAN
A:
[10-265]
-----------------------
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
--
L
N
R
Q
K
-
I
R
S
-----
L
D
----
V
-
V
---
G
K
I
K
---
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
---
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
H
---
M
----
N
---
A
K
I
A
D
F
G
L
-
S
--------------------------
N
Y
A
A
P
E
--------
Y
A
-----
G
--
P
E
-----
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
--
E
H
V
P
-
T
L
F
K
K
I
R
--
G
G
--
V
F
Y
---
I
--
P
----
E
----
Y
--
L
N
-------
R
S
-------
V
A
T
L
----
L
M
H
M
L
Q
V
D
P
L
K
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
Blastp_CBE
56.16
41%
-23
- C2 -
-
4CZU
5.9
-
CIPKN_ARATH
B:
[10-295]
-----------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
--
I
D
K
E
K
V
L
-
K
-----
N
K
----
M
-
I
---
A
Q
I
K
---
R
E
I
S
T
M
K
L
I
K
-
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
L
K
E
---
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
A
N
---
G
----
A
---
L
K
V
S
D
F
G
L
-
S
-
A
-
L
PQ-
Q
V
R
E
--
D
-
G
L
L
H
D
T
-
C
G
T
P
N
Y
V
A
P
E
V
I
--
N
N
K
G
Y
D
-----
G
--
A
K
-----
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
--
S
N
L
T
-
S
L
Y
K
K
I
F
--
K
A
--
E
F
T
---
C
--
P
----
P
----
W
--
F
S
-------
A
S
-------
A
K
K
L
----
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
E
V
I
E
N
E
W
F
K
K
G
Y
K
A
P
K
---
F
E
---------------
D
D
V
D
A
I
F
D
D
--
S
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
199
Blastp_CBE
56.10
33%
-52
- C2 -
-
4Y5Q
4.7
-
?
A:
[14-334]
--------
L
Y
F
Q
--------
G
T
F
A
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
--
I
N
K
A
S
-
A
-
K
-----
N
K
----
D
-
T
---
S
T
I
L
---
R
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
E
---
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
---
E
S
K
---
E
KDC-
D
---
I
K
I
I
D
F
G
L
-
S
-
T
-
C
---
F
Q
-
Q
--
N
-
T
---
D
R
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
R
G
-
T
Y
D
--------
E
K
-----
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
--
K
N
E
Y
-
D
I
L
K
R
V
E
--
T
G
KY
A
F
D
---
L
--
P
----
Q
----
W
RT
I
S
-------
D
D
-------
A
K
D
L
----
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
A
T
Q
C
L
E
H
P
W
I
----
Q
K
Y
S
---
S
E
T
P
-----
T
I
S
D
L
P
S
L
E
-------
S
--
A
M
T
N
I
R
Q
F
Q
A
E
K
K
L
A
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
201
Blastp_CBE
55.95
33%
-58
- C2 -
-
3MWU
6.5
-
?
A:
[14-334]
--------
L
Y
F
Q
--------
G
T
F
A
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
--
I
N
K
A
S
-
A
-
K
-----
N
K
----
D
-
T
---
S
T
I
L
---
R
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
E
---
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
---
E
S
K
---
E
KDC-
D
---
I
K
I
I
D
F
G
L
-
S
-
T
-
C
---
F
Q
-
Q
--
N
-----
D
R
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
R
G
-
T
Y
D
--------
E
K
-----
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
--
K
N
E
Y
-
D
I
L
K
R
V
E
--
T
G
KY
A
F
D
---
L
--
P
----
Q
----
W
RT
I
S
-------
D
D
-------
A
K
D
L
----
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
A
T
Q
C
L
E
H
P
W
I
----
Q
K
Y
S
---
S
E
T
P
-----
T
I
S
D
L
P
S
L
E
-------
S
--
A
M
T
N
I
R
Q
F
Q
A
E
K
K
L
A
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
202
Blastp_CBE
55.57
33%
-58
- C2 -
-
3IGO
4.9
-
?
A:
[17-329]
-----------
Q
--------
G
T
F
A
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
--
I
N
K
A
S
-
A
-
K
-----
N
K
------
T
---
S
T
I
L
---
R
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
E
---
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
---
E
S
K
---
E
KDC-
D
---
I
K
I
I
D
F
G
L
-
S
-
T
-
C
---
F
Q
-
Q
--
N
-
T
--------
T
A
Y
Y
I
A
P
E
V
L
--
R
G
-
T
Y
D
--------
E
K
-----
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
--
K
N
E
Y
-
D
I
L
K
R
V
E
--
T
G
KY
A
F
D
---
L
--
P
----
Q
----
W
RT
I
S
-------
D
D
-------
A
K
D
L
----
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
A
T
Q
C
L
E
H
P
W
I
----
Q
K
Y
S
---
S
E
T
P
-----
T
I
S
D
L
P
S
L
E
-------
S
--
A
M
T
N
I
R
Q
F
Q
A
E
K
K
L
A
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
Blastp_CBE
55.53
42%
-9
- C2 -
-
5UFU
8.8
-
AAPK1_MOUSE (first)
A:
[15-501]
-----------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
--
L
N
R
Q
K
-
I
R
S
-----
L
D
----
V
-
V
---
G
K
I
R
---
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
---
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
H
---
M
----
N
---
A
K
I
A
D
F
G
L
-
S
-
N
-
M
----
M
-
S
--
D
-
G
E
F
L
R
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
G
R
L
Y
A
-----
G
--
P
E
-----
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
--
D
H
V
P
-
T
L
F
K
K
I
C
--
D
G
--
I
F
Y
---
T
--
P
----
Q
----
Y
--
L
N
-------
P
S
-------
V
I
S
L
----
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
--
K
Q
D
L
P
K
YLF
P
E
D
P
S
Y
S
S
T
M
I
D
D
E
A
L
K
E
V
C
E
K
F
E
C
S
--
E
E
E
V
L
S
C
L
Y
N
R
N
H
--
Q
D
P
L
A
-------
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
F
Y
L
A
----
T
S
P
P
D
S
F
L
D
--
H
L
T
R
P
H
P
E
R
V
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Blastp_CBE
55.48
42%
-7
- C2 -
-
6E4W
9.0
-
?
A:
[15-503]
-----------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
--
L
N
R
Q
K
-
I
R
S
-----
L
D
----
V
-
V
---
G
K
I
R
---
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
---
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
H
---
M
----
N
---
A
K
I
A
D
F
G
L
-
S
-
N
-
M
----
M
-
S
--
D
-
G
E
F
L
R
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
G
R
L
Y
A
-----
G
--
P
E
-----
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
--
D
H
V
P
-
T
L
F
K
K
I
C
--
D
G
--
I
F
Y
---
T
--
P
----
Q
----
Y
--
L
N
-------
P
S
-------
V
I
S
L
----
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
--
K
Q
D
L
P
K
YLF
P
E
D
P
S
Y
S
S
T
M
I
D
D
E
A
L
K
E
V
C
E
K
F
E
C
S
--
E
E
E
V
L
S
C
L
Y
N
R
N
H
--
Q
D
P
L
A
-------
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
F
Y
L
A
----
T
S
P
P
D
S
--
D
D
H
H
L
T
R
P
H
P
E
R
V
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
478
Blastp_CBE
55.36
34%
-79
- C2 -
-
2E9V
6.9
-
CHK1_HUMAN
B:
[4-264]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
R
-
A
-
V
-----
D
C
----
P
-----
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
419
Blastp_CBE
55.31
34%
-76
- C2 -
-
6FC8
6.2
-
CHK1_HUMAN
A:
[5-265]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
R
-
A
-
V
-----
D
C
----
P
-----
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
Blastp_CBE
55.25
42%
-10
- C2 -
-
5T5T
9.1
-
AAPK1_RAT
A:
[15-501]
-----------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
--
L
N
R
Q
K
-
I
R
S
-----
L
D
----
V
-
V
---
G
K
I
R
---
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
---
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
H
---
M
----
N
---
A
K
I
A
D
F
G
L
-
S
-
N
-
M
----
M
-
S
--
D
-
G
E
F
L
R
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
G
R
L
Y
A
-----
G
--
P
E
-----
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
--
D
H
V
P
-
T
L
F
K
K
I
C
--
D
G
--
I
F
Y
---
T
--
P
----
Q
----
Y
--
L
N
-------
P
S
-------
V
I
S
L
----
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
--
K
Q
D
L
P
K
YLF
P
E
D
P
S
Y
S
S
T
M
I
D
D
E
A
L
K
E
V
C
E
K
F
E
C
S
--
E
E
E
V
L
S
C
L
Y
N
R
N
H
--
Q
D
P
L
A
-------
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
F
Y
L
A
----
T
S
P
P
D
S
F
L
D
--
H
L
T
R
P
H
P
E
R
V
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
477
Blastp_CBE
54.85
34%
-78
- C2 -
-
2E9N
6.3
-
CHK1_HUMAN
A:
[4-264]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
R
-
A
-
V
-----
D
C
----
P
-----
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
418
Blastp_CBE
54.75
34%
-75
- C2 -
-
6FCK
6.8
-
CHK1_HUMAN
A:
[5-265]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
R
-
A
-
V
-----
D
C
----
P
-----
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
144
Blastp_CBE
54.73
39%
-95
- C2 -
-
4FG9
6.0
-
KCC1A_HUMAN
A:
[20-278]
--------------------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
--
I
A
K
E
-------------------------
E
---
N
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
---
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
---
D
E
D
---
S
----
K
---
I
M
I
S
D
F
-----------------------------
P
G
Y
V
A
P
E
V
L
--
A
Q
K
P
Y
------
S
--
K
A
-----
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
--
E
N
D
A
-
K
L
F
E
Q
I
L
--
K
A
--
E
Y
E
---
F
DS
P
----
Y
----
W
DD
I
S
-------
D
S
-------
A
K
D
F
----
I
R
H
L
M
E
K
D
P
E
K
R
F
-----
T
C
E
Q
A
L
Q
H
P
W
I
A
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
523
Blastp_CBE
54.62
34%
-89
- C2 -
-
5OQ5
7.8
-
CHK1_HUMAN
A:
[5-265]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
R
----------
C
----
P
-----
E
N
I
K
---
K
E
I
C
I
L
K
M
L
N
-
H
E
N
V
I
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
M
E
L
A
S
G
G
S
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
H
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
A
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
339
Blastp_CBE
54.58
34%
-75
- C2 -
-
2YDI
4.4
-
CHK1_HUMAN
A:
[5-265]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
R
-
A
-
V
-----
D
C
----
P
-----
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Blastp_CBE
54.39
42%
-5
- C2 -
-
4QFG
9.8
-
AAPK1_RAT
A:
[15-501]
-----------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
--
L
N
R
Q
K
-
I
R
S
-----
L
D
----
V
-
V
---
G
K
I
R
---
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
---
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
H
---
M
----
N
---
A
K
I
A
D
F
G
L
-
S
-
N
-
M
----
M
-
S
--
D
-
G
E
F
L
R
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
G
R
L
Y
A
-----
G
--
P
E
-----
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
--
D
H
V
P
-
T
L
F
K
K
I
C
--
D
G
--
I
F
Y
---
T
--
P
----
Q
----
Y
--
L
N
-------
P
S
-------
V
I
S
L
----
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
--
K
Q
D
L
P
K
YLF
P
E
D
P
S
Y
S
S
T
M
I
D
D
E
A
L
K
E
V
C
E
K
F
E
C
S
--
E
E
E
V
L
S
C
L
Y
N
R
N
H
--
Q
D
P
L
A
-------
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
F
Y
L
A
----
T
S
P
P
D
S
--
D
D
H
H
L
T
R
P
H
P
E
R
V
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
479
Blastp_CBE
54.37
34%
-75
- C2 -
-
2E9V
6.8
-
CHK1_HUMAN
A:
[4-264]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
R
-
A
-
V
-----
D
C
----
P
-----
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
264
Blastp_CBE
54.23
32%
-101
- C2 -
-
5XZV
5.3
-
RAD53_YEAST
A:
[200-465]
----------------------------
I
D
E
V
V
G
Q
G
A
F
A
T
V
K
K
A
I
E
R
T
T
G
K
T
F
A
V
K
I
--
I
S
K
R
K
-
V
-
I
-----
G
N
------
M
---
D
G
V
T
---
R
E
L
E
V
L
Q
K
L
N
-
H
P
R
I
V
R
L
K
G
F
Y
E
D
T
E
S
Y
Y
M
V
M
E
F
V
S
G
G
D
L
M
D
F
V
A
A
H
G
A
V
G
E
---
D
A
G
R
E
I
S
R
Q
I
L
T
A
I
K
Y
I
H
S
M
G
I
S
H
R
D
L
K
P
D
N
I
L
---
I
---
E
Q
D
---
D
PV--
L
---
V
K
I
T
D
F
G
L
-
A
-
K
-----------------------
L
A
Y
V
A
P
E
V
I
-----------------
N
EYSSL
V
D
M
W
S
M
G
C
L
V
Y
V
I
L
T
G
H
L
P
F
----
S
T
Q
D
-
Q
L
Y
K
Q
I
G
--
R
G
--
S
-----
L
--
K
----
D
----
F
R-
I
S
-------
E
E
-------
A
R
D
F
----
I
D
S
L
---
D
P
N
N
-------
T
A
A
K
A
L
N
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
118
Blastp_CBE
54.20
37%
-83
- C2 -
-
6BAB
7.3
-
KCC2D_MOUSE
D:
[10-272]
---------------------
R
F
-
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
--
I
N
T
K
K
-
L
-
S
-----
A
R
----
D
-
H
---
Q
K
L
E
---
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
---
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
K
---
S
----
K
GAA
V
K
L
A
D
F
G
L
-
A
-
I
-
E
---
V
Q
-
G
--
D
-
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
--
R
K
D
P
Y
------
G
--
K
P
-----
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
--
E
D
Q
H
-
R
L
Y
Q
Q
I
K
--
A
G
--
A
Y
D
---
F
--
P
SPEW
D
----
T
--
V
T
-------
P
E
-------
A
K
D
L
----
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
L
K
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
143
Blastp_CBE
54.19
39%
-94
- C2 -
-
4FG9
5.2
-
KCC1A_HUMAN
B:
[20-278]
--------------------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
--
I
A
K
-------------------------------
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
---
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
---
D
E
D
---
S
----
K
---
I
M
I
S
D
F
--------------------
V
L
S
T
A
-
C
G
T
P
G
Y
V
A
P
E
V
L
--
A
Q
K
P
Y
------
S
--
K
A
-----
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
--
E
N
D
A
-
K
L
F
E
Q
I
L
--
K
A
--
E
Y
E
---
F
DS
P
----
Y
----
W
DD
I
S
-------
D
S
-------
A
K
D
F
----
I
R
H
L
M
E
K
D
P
E
K
R
F
-----
T
C
E
Q
A
L
Q
H
P
W
I
A
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
Blastp_CBE
54.19
42%
-6
- C2 -
-
4QFS
9.5
-
AAPK1_RAT
A:
[15-503]
-----------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
--
L
N
R
Q
K
-
I
R
S
-----
L
D
----
V
-
V
---
G
K
I
R
---
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
---
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
H
---
M
----
N
---
A
K
I
A
D
F
G
L
-
S
-
N
-
M
----
M
-
S
--
D
-
G
E
F
L
R
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
G
R
L
Y
A
-----
G
--
P
E
-----
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
--
D
H
V
P
-
T
L
F
K
K
I
C
--
D
G
--
I
F
Y
---
T
--
P
----
Q
----
Y
--
L
N
-------
P
S
-------
V
I
S
L
----
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
--
K
Q
D
L
P
K
YLF
P
E
D
P
S
Y
S
S
T
M
I
D
D
E
A
L
K
E
V
C
E
K
F
E
C
S
--
E
E
E
V
L
S
C
L
Y
N
R
N
H
--
Q
D
P
L
A
-------
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
F
Y
L
A
----
T
S
P
P
D
S
--
D
D
H
H
L
T
R
P
H
P
E
R
V
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
420
Blastp_CBE
54.07
34%
-67
- C2 -
-
2YEX
6.2
-
CHK1_HUMAN
A:
[5-265]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
R
-
A
-
V
-----
D
C
----
P
-----
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
195
Blastp_CBE
53.99
34%
-65
- C2 -
-
2WEI
5.7
-
?
A:
[9-279]
---
S
G
R
E
N
L
Y
F
Q
--------
G
T
F
A
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
--
I
N
K
A
S
-
A
-
K
-----
N
K
----
D
-
T
---
S
T
I
L
---
R
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
E
---
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
---
E
S
K
---
E
KDC-
D
---
I
K
I
I
D
F
G
L
-
S
-
T
-
C
---
F
Q
-
Q
--
N
-
T
K
M
K
D
R
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
R
G
-
T
Y
D
--------
E
K
-----
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
--
K
N
E
Y
-
D
I
L
K
R
V
E
--
T
G
KY
A
F
D
---
L
--
P
----
Q
----
W
RT
I
S
-------
D
D
-------
A
K
D
L
----
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
A
T
Q
C
L
E
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
480
Blastp_CBE
53.84
34%
-75
- C2 -
-
2AYP
7.3
-
CHK1_HUMAN
A:
[5-265]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
R
-
A
-
V
-----
D
C
----
P
-----
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Blastp_CBE
53.81
42%
-2
- C2 -
-
6E4T
8.8
-
?
A:
[15-503]
-----------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
--
L
N
R
Q
K
-
I
R
S
-----
L
D
----
V
-
V
---
G
K
I
R
---
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
---
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
H
---
M
----
N
---
A
K
I
A
D
F
G
L
-
S
-
N
-
M
----
M
-
S
--
D
-
G
E
F
L
R
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
G
R
L
Y
A
-----
G
--
P
E
-----
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
--
D
H
V
P
-
T
L
F
K
K
I
C
--
D
G
--
I
F
Y
---
T
--
P
----
Q
----
Y
--
L
N
-------
P
S
-------
V
I
S
L
----
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
--
K
Q
D
L
P
K
YLF
P
E
D
P
S
Y
S
S
T
M
I
D
D
E
A
L
K
E
V
C
E
K
F
E
C
S
--
E
E
E
V
L
S
C
L
Y
N
R
N
H
--
Q
D
P
L
A
-------
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
F
Y
L
A
----
T
S
P
P
D
S
--
D
D
H
H
L
T
R
P
H
P
E
R
V
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
521
Blastp_CBE
53.79
34%
-85
- C2 -
-
5OQ7
5.5
-
CHK1_HUMAN
B:
[8-265]
-------------------------
D
W
D
L
V
Q
T
L
G
E
G
--
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
------------
C
----
P
-----
E
N
I
K
---
K
E
I
C
I
L
K
M
L
N
-
H
E
N
V
I
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
M
E
L
A
S
G
G
S
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
H
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
A
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
371
Blastp_CBE
53.74
34%
-80
- C2 -
-
2BRO
6.6
-
CHK1_HUMAN
A:
[5-265]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
R
----------
C
----
P
-----
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
474
Blastp_CBE
53.67
34%
-74
- C2 -
-
2E9U
6.3
-
CHK1_HUMAN
A:
[4-264]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
R
-
A
-
V
-----
D
C
----
P
-----
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
421
Blastp_CBE
53.63
34%
-68
- C2 -
-
2YER
6.3
-
CHK1_HUMAN
A:
[5-265]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
R
-
A
-
V
-----
D
C
----
P
-----
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
344
Blastp_CBE
53.64
34%
-74
- C2 -
-
2X8D
5.0
-
CHK1_HUMAN
A:
[5-265]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
R
-
A
-
V
-----
D
C
----
P
-----
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
137
Blastp_CBE
53.63
39%
-86
- C2 -
-
4FG8
4.0
-
KCC1A_HUMAN
B:
[20-278]
--------------------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
--
I
A
K
------------------------------
N
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
---
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
---
D
E
D
---
S
----
K
---
I
M
I
S
D
F
G
----------------
G
-
S
V
L
S
T
A
-
C
G
T
P
G
Y
V
A
P
E
V
L
--
A
Q
K
P
Y
------
S
--
K
A
-----
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
--
E
N
D
A
-
K
L
F
E
Q
I
L
--
K
A
EY
E
F
D
---
S
--
P
----
Y
----
W
DD
I
S
-------
D
S
-------
A
K
D
F
----
I
R
H
L
M
E
K
D
P
E
K
R
F
-----
T
C
E
Q
A
L
Q
H
P
W
I
A
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
365
Blastp_CBE
53.59
34%
-76
- C2 -
-
2CGW
4.3
-
CHK1_HUMAN
A:
[6-265]
-----------------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
R
---------------
P
-----
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
Blastp_CBE
53.59
42%
-2
- C2 -
-
4QFR
10.2
-
?
A:
[15-503]
-----------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
--
L
N
R
Q
K
-
I
R
S
-----
L
D
----
V
-
V
---
G
K
I
R
---
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
---
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
H
---
M
----
N
---
A
K
I
A
D
F
G
L
-
S
-
N
-
M
----
M
-
S
--
D
-
G
E
F
L
R
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
G
R
L
Y
A
-----
G
--
P
E
-----
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
--
D
H
V
P
-
T
L
F
K
K
I
C
--
D
G
--
I
F
Y
---
T
--
P
----
Q
----
Y
--
L
N
-------
P
S
-------
V
I
S
L
----
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
--
K
Q
D
L
P
K
YLF
P
E
D
P
S
Y
S
S
T
M
I
D
D
E
A
L
K
E
V
C
E
K
F
E
C
S
--
E
E
E
V
L
S
C
L
Y
N
R
N
H
--
Q
D
P
L
A
-------
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
F
Y
L
A
----
T
S
P
P
D
S
--
D
D
H
H
L
T
R
P
H
P
E
R
V
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
376
Blastp_CBE
53.55
34%
-73
- C2 -
-
2BRB
6.3
-
CHK1_HUMAN
A:
[5-265]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
R
----------
C
----
P
-----
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
422
Blastp_CBE
53.50
34%
-69
- C2 -
-
2YDK
5.3
-
CHK1_HUMAN
A:
[5-265]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
R
---------------------
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
138
Blastp_CBE
53.44
39%
-96
- C2 -
-
4FG8
5.3
-
KCC1A_HUMAN
A:
[20-278]
--------------------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
--
I
A
K
--------------------------
E
---
N
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
---
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
---
D
E
D
---
S
----
K
---
I
M
I
S
D
F
----------------------------
T
P
G
Y
V
A
P
E
V
L
--
A
Q
K
P
Y
------
S
--
K
A
-----
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
--
E
N
D
A
-
K
L
F
E
Q
I
L
--
K
A
EY
E
F
D
---
S
--
P
----
Y
----
W
DD
I
S
-------
D
S
-------
A
K
D
F
----
I
R
H
L
M
E
K
D
P
E
K
R
F
-----
T
C
E
Q
A
L
Q
H
P
W
I
A
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
369
Blastp_CBE
53.34
34%
-70
- C2 -
-
2C3K
8.2
-
CHK1_HUMAN
A:
[6-265]
-----------------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
R
----------
C
----
P
-----
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
377
Blastp_CBE
53.24
34%
-74
- C2 -
-
2BR1
6.2
-
CHK1_HUMAN
A:
[5-265]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
R
----------
C
----
P
-----
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
331
Blastp_CBE
53.21
34%
-74
- C2 -
-
4HYI
6.8
-
CHK1_HUMAN
A:
[5-265]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
R
---------------
P
-----
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
454
Blastp_CBE
53.17
34%
-75
- C2 -
-
3U9N
6.7
-
CHK1_HUMAN
A:
[6-264]
------------------------
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
------------------------
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
373
Blastp_CBE
53.16
34%
-73
- C2 -
-
2BRM
6.1
-
CHK1_HUMAN
A:
[7-265]
------------------------
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
------------
C
----
P
-----
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
433
Blastp_CBE
53.15
34%
-80
- C2 -
-
4FTU
6.8
-
CHK1_HUMAN
A:
[4-264]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
364
Blastp_CBE
53.11
34%
-73
- C2 -
-
2CGX
3.7
-
CHK1_HUMAN
A:
[6-265]
-----------------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
R
----------
C
----
P
-----
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
366
Blastp_CBE
53.08
34%
-73
- C2 -
-
2CGV
5.1
-
CHK1_HUMAN
A:
[6-265]
-----------------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
R
----------
C
----
P
-----
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
269
Blastp_CBE
53.06
37%
-82
- C2 -
-
2YCF
8.4
-
CHK2_HUMAN
A:
[12-277]
--------------------------
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
------------------------
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
G
-
E
--
T
-
S
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
--
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
--
S
G
--
K
Y
------------
N
----
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
476
Blastp_CBE
53.05
34%
-65
- C2 -
-
2E9O
7.4
-
CHK1_HUMAN
A:
[4-264]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
R
-
A
-
V
-----
D
C
----
P
-----
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
443
Blastp_CBE
52.97
34%
-77
- C2 -
-
4FT7
7.4
-
CHK1_HUMAN
A:
[4-264]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
254
Blastp_CBE
52.97
34%
-72
- C2 -
-
2HXQ
6.9
-
CHK1_HUMAN
A:
[4-264]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
R
----------
C
----
P
-----
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
457
Blastp_CBE
52.96
34%
-79
- C2 -
-
3PA3
6.6
-
CHK1_HUMAN
A:
[4-264]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
259
Blastp_CBE
52.92
34%
-81
- C2 -
-
3TKH
5.7
-
CHK1_HUMAN
A:
[5-265]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
--------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
522
Blastp_CBE
52.89
34%
-79
- C2 -
-
5OQ7
6.5
-
CHK1_HUMAN
A:
[8-265]
-------------------------
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
------------
C
----
P
-----
E
N
I
K
---
K
E
I
C
I
L
K
M
L
N
-
H
E
N
V
I
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
M
E
L
A
S
G
G
S
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
H
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
A
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
423
Blastp_CBE
52.87
34%
-77
- C2 -
-
2X8E
6.0
-
CHK1_HUMAN
A:
[9-265]
--------------------------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
R
----------
C
----
P
-----
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
265
Blastp_CBE
52.81
37%
-89
- C2 -
-
2YCR
7.0
-
CHK2_HUMAN
A:
[12-277]
--------------------------
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
------------------------
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
G
-
E
--
T
-
S
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
--
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
--
S
G
--
K
Y
------------
N
----
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
351
Blastp_CBE
52.80
34%
-76
- C2 -
-
2WMR
3.8
-
CHK1_HUMAN
A:
[7-265]
------------------------
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
367
Blastp_CBE
52.79
34%
-77
- C2 -
-
2CGU
5.5
-
CHK1_HUMAN
A:
[6-265]
-----------------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
R
----------
C
----
P
-----
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
251
Blastp_CBE
52.78
37%
-86
- C2 -
-
2CN5
6.2
-
CHK2_HUMAN
A:
[18-283]
--------------------------
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
R
-----------------------
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
G
-
E
--
T
-
S
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
--
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
--
S
G
--
K
Y
------------
N
----
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
445
Blastp_CBE
52.77
34%
-75
- C2 -
-
4FT0
7.5
-
CHK1_HUMAN
A:
[4-268]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
------------------------
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
472
Blastp_CBE
52.75
34%
-68
- C2 -
-
2YWP
5.3
-
CHK1_HUMAN
A:
[4-264]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
R
-
A
-
V
-----
D
C
----
P
-----
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
372
Blastp_CBE
52.74
34%
-75
- C2 -
-
2BRN
5.8
-
CHK1_HUMAN
A:
[6-265]
-----------------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
R
----------
C
----
P
-----
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
343
Blastp_CBE
52.62
34%
-72
- C2 -
-
2X8I
6.1
-
CHK1_HUMAN
A:
[5-265]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
-----------------------
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
332
Blastp_CBE
52.61
34%
-75
- C2 -
-
4HYH
7.8
-
CHK1_HUMAN
A:
[5-265]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
-----------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
258
Blastp_CBE
52.59
34%
-78
- C2 -
-
3TKI
7.2
-
CHK1_HUMAN
A:
[5-265]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
-----------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
370
Blastp_CBE
52.58
34%
-75
- C2 -
-
2C3J
4.9
-
CHK1_HUMAN
A:
[6-265]
-----------------------
V
E
D
W
D
L
V
Q
T
L
G
E
---
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
R
---------------------
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
441
Blastp_CBE
52.55
34%
-79
- C2 -
-
4FTI
8.3
-
CHK1_HUMAN
A:
[4-264]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
-----------------------
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
389
Blastp_CBE
52.57
34%
-76
- C2 -
-
4FSU
8.1
-
CHK1_HUMAN
A:
[4-264]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
A
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
------------------------
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
255
Blastp_CBE
52.55
34%
-73
- C2 -
-
2HXL
6.2
-
CHK1_HUMAN
A:
[4-264]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
R
----------
C
----
P
-----
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
281
Blastp_CBE
52.50
33%
-15
- C2 -
-
2F7X
6.1
-
KAPCA_BOVIN
E:
[35-298]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
--
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
229
Blastp_CBE
52.50
37%
-92
- C2 -
-
4BDJ
5.4
-
CHK2_HUMAN
A:
[18-283]
--------------------------
Y
I
M
S
K
T
L
-----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
------------------------
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
--
E
--
T
-
S
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
--
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
--
S
G
--
K
Y
------------
N
----
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
475
Blastp_CBE
52.46
34%
-71
- C2 -
-
2E9P
5.4
-
CHK1_HUMAN
A:
[4-264]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
R
-
A
-
V
-----
D
C
----
P
-----
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
456
Blastp_CBE
52.36
34%
-79
- C2 -
-
3PA4
6.5
-
CHK1_HUMAN
A:
[5-264]
-----------------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
-
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
360
Blastp_CBE
52.35
34%
-74
- C2 -
-
2GDO
6.8
-
CHK1_HUMAN
A:
[5-265]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
-----------
C
----
P
-----
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
233
Blastp_CBE
52.20
37%
-88
- C2 -
-
4BDF
4.7
-
CHK2_HUMAN
A:
[18-283]
--------------------------
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
------------------------
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
G
-
E
--
T
-
S
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
--
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
--
S
G
--
K
Y
------------
N
----
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
277
Blastp_CBE
52.18
37%
-84
- C2 -
-
2XK9
7.5
-
CHK2_HUMAN
A:
[11-276]
--------------------------
Y
I
M
S
K
T
L
G
S
G
A
-
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
------------------------
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
G
-
E
--
T
-
S
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
--
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
--
S
G
--
K
Y
------------
N
----
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
363
Blastp_CBE
52.17
34%
-70
- C2 -
-
3NLB
6.3
-
CHK1_HUMAN
A:
[6-265]
-----------------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
R
---------------------
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
232
Blastp_CBE
52.14
37%
-88
- C2 -
-
4BDG
3.8
-
CHK2_HUMAN
A:
[18-283]
--------------------------
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
------------------------
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
G
-
E
--
T
-
S
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
--
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
--
S
G
--
K
Y
------------
N
----
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
276
Blastp_CBE
52.12
37%
-95
- C2 -
-
2W0J
7.2
-
CHK2_HUMAN
A:
[12-278]
--------------------------
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
------------------------
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
-----
T
-
S
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
--
V
S
V
G
T
A
-----
G
YN
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
--
S
G
--
K
Y
------------
N
----
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
361
Blastp_CBE
52.09
34%
-72
- C2 -
-
1ZLT
5.2
-
CHK1_HUMAN
A:
[5-265]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
R
----------
C
----
P
-----
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
442
Blastp_CBE
52.06
34%
-80
- C2 -
-
4FT9
6.0
-
CHK1_HUMAN
A:
[4-264]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
--
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
-----------------------
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
342
Blastp_CBE
52.06
34%
-78
- C2 -
-
2XEY
6.3
-
CHK1_HUMAN
A:
[6-265]
-----------------------
V
E
D
W
D
L
V
Q
T
L
G
----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
------------------------
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
253
Blastp_CBE
52.05
34%
-77
- C2 -
-
2HY0
8.3
-
CHK1_HUMAN
A:
[4-264]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
-----------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
382
Blastp_CBE
52.03
34%
-75
- C2 -
-
4QYH
7.1
-
CHK1_HUMAN
A:
[5-265]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
-----------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
391
Blastp_CBE
52.00
33%
-12
- C2 -
-
2UZV
6.3
-
KAPCA_BOVIN
A:
[20-283]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
--
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
275
Blastp_CBE
52.01
37%
-89
- C2 -
-
2W7X
7.7
-
CHK2_HUMAN
A:
[12-277]
--------------------------
Y
I
M
S
K
T
L
G
S
G
A
-
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
------------------------
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
G
-
E
--
T
-
S
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
--
V
S
V
G
T
A
-----
G
YN
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
--
S
G
--
K
Y
------------
N
----
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
260
Blastp_CBE
52.00
34%
-80
- C2 -
-
2R0U
6.9
-
CHK1_HUMAN
A:
[5-265]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
---
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
-----------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
473
Blastp_CBE
51.96
34%
-69
- C2 -
-
2GHG
6.5
-
CHK1_HUMAN
A:
[4-264]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
R
-
A
-
V
-----
D
C
----
P
-----
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
235
Blastp_CBE
51.99
37%
-99
- C2 -
-
4BDD
4.5
-
CHK2_HUMAN
A:
[18-283]
--------------------------
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
------------------------
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
-----
T
-
S
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
--
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
--
S
G
--
K
Y
------------
N
----
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
355
Blastp_CBE
51.96
34%
-79
- C2 -
-
1NVQ
8.4
-
CHK1_HUMAN
A:
[5-265]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
-----------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
347
Blastp_CBE
51.96
34%
-82
- C2 -
-
2WMV
4.4
-
CHK1_HUMAN
A:
[7-265]
------------------------
E
D
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
335
Blastp_CBE
51.95
34%
-80
- C2 -
-
2YM6
5.3
-
CHK1_HUMAN
A:
[7-265]
------------------------
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
-------------------------
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
278
Blastp_CBE
51.94
33%
-16
- C2 -
-
2OJF
5.3
-
KAPCA_BOVIN
E:
[35-298]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
--
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
393
Blastp_CBE
51.90
33%
-18
- C2 -
-
2UZT
6.1
-
KAPCA_BOVIN
A:
[20-283]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
--
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
459
Blastp_CBE
51.87
34%
-79
- C2 -
-
3OT3
7.6
-
CHK1_HUMAN
A:
[4-264]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
-
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
-----------------------
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
362
Blastp_CBE
51.84
34%
-75
- C2 -
-
5DLS
7.4
-
CHK1_HUMAN
A:
[6-265]
-----------------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
346
Blastp_CBE
51.83
34%
-79
- C2 -
-
2WMW
4.7
-
CHK1_HUMAN
A:
[7-265]
------------------------
E
D
W
D
L
V
Q
T
L
G
------
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
375
Blastp_CBE
51.80
34%
-74
- C2 -
-
2BRG
5.0
-
CHK1_HUMAN
A:
[7-265]
------------------------
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
----------------------
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
444
Blastp_CBE
51.75
34%
-82
- C2 -
-
4FT5
6.4
-
CHK1_HUMAN
A:
[4-264]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
270
Blastp_CBE
51.74
37%
-90
- C2 -
-
2YIT
7.9
-
CHK2_HUMAN
A:
[12-277]
--------------------------
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
-----------------------
L
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
G
-
E
--
T
-
S
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
--
V
S
V
G
T
A
-----
G
YN
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
--
S
G
--
K
Y
------------
N
----
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
439
Blastp_CBE
51.71
34%
-83
- C2 -
-
4FTK
8.7
-
CHK1_HUMAN
A:
[4-264]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
--------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
386
Blastp_CBE
51.68
34%
-77
- C2 -
-
4QYE
7.0
-
CHK1_HUMAN
A:
[5-265]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
-----------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
236
Blastp_CBE
51.68
37%
-91
- C2 -
-
4BDC
3.7
-
CHK2_HUMAN
A:
[18-283]
--------------------------
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
------------------------
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
--
E
--
T
-
S
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
--
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
--
S
G
--
K
Y
------------
N
----
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
383
Blastp_CBE
51.66
34%
-73
- C2 -
-
4QYG
7.2
-
CHK1_HUMAN
B:
[5-265]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
-----------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
446
Blastp_CBE
51.60
34%
-77
- C2 -
-
4FSR
8.0
-
CHK1_HUMAN
A:
[4-264]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
--
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
-----------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
256
Blastp_CBE
51.57
34%
-76
- C2 -
-
2HOG
7.8
-
CHK1_HUMAN
A:
[4-264]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
-----------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
471
Blastp_CBE
51.52
34%
-79
- C2 -
-
5F4N
6.4
-
CHK1_HUMAN
A:
[5-265]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
-------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
385
Blastp_CBE
51.53
34%
-75
- C2 -
-
4QYF
6.0
-
CHK1_HUMAN
A:
[5-267]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
-----------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
384
Blastp_CBE
51.53
34%
-72
- C2 -
-
4QYG
5.9
-
CHK1_HUMAN
A:
[5-265]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
-----------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
349
Blastp_CBE
51.51
34%
-84
- C2 -
-
2WMT
2.8
-
CHK1_HUMAN
A:
[8-265]
-------------------------
D
W
D
L
V
Q
T
L
G
-----
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
354
Blastp_CBE
51.52
34%
-78
- C2 -
-
1NVR
9.2
-
CHK1_HUMAN
A:
[5-265]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
-----------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
282
Blastp_CBE
51.51
33%
-17
- C2 -
-
2F7E
6.0
-
KAPCA_BOVIN
E:
[35-298]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
--
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
237
Blastp_CBE
51.50
37%
-96
- C2 -
-
4BDB
3.7
-
CHK2_HUMAN
A:
[18-283]
--------------------------
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
-----------------------
L
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
--
E
--
T
-
S
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
--
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
--
S
G
--
K
Y
------------
N
----
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
374
Blastp_CBE
51.48
34%
-75
- C2 -
-
2BRH
5.9
-
CHK1_HUMAN
A:
[6-265]
-----------------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
-------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
273
Blastp_CBE
51.36
37%
-92
- C2 -
-
2YCS
7.0
-
CHK2_HUMAN
A:
[12-277]
--------------------------
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
------------------------
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
-----
T
-
S
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
--
V
S
V
G
T
A
-----
G
YN
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
--
S
G
--
K
Y
------------
N
----
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
448
Blastp_CBE
51.35
34%
-81
- C2 -
-
4FSM
7.3
-
CHK1_HUMAN
A:
[4-264]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
---
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
--------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
380
Blastp_CBE
51.33
34%
-76
- C2 -
-
4RVK
7.6
-
CHK1_HUMAN
A:
[5-265]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
-----------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
434
Blastp_CBE
51.29
34%
-78
- C2 -
-
4FTT
6.9
-
CHK1_HUMAN
A:
[4-264]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
---
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
-------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
392
Blastp_CBE
51.29
33%
-14
- C2 -
-
2UZU
5.0
-
KAPCA_BOVIN
E:
[20-283]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
--
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
390
Blastp_CBE
51.24
33%
-15
- C2 -
-
2UZW
5.0
-
KAPCA_BOVIN
E:
[20-283]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
--
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
438
Blastp_CBE
51.20
34%
-84
- C2 -
-
4FTL
9.5
-
CHK1_HUMAN
A:
[4-264]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
--------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
381
Blastp_CBE
51.17
34%
-73
- C2 -
-
4QYH
7.0
-
CHK1_HUMAN
B:
[5-265]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
-----------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
453
Blastp_CBE
51.18
34%
-80
- C2 -
-
4JIK
7.0
-
CHK1_HUMAN
A:
[4-264]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
-
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
---------------------------
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
368
Blastp_CBE
51.17
34%
-78
- C2 -
-
2C3L
4.4
-
CHK1_HUMAN
A:
[5-265]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
R
-----------------------
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
263
Blastp_CBE
51.15
32%
-91
- C2 -
-
5XZV
3.1
-
?
B:
[200-467]
----------------------------
I
D
E
V
V
G
Q
G
A
F
A
T
V
K
K
A
I
E
R
T
T
G
K
T
F
A
V
K
I
--
I
S
K
R
K
-----------------
M
---
D
G
V
T
---
R
E
L
E
V
L
Q
K
L
N
-
H
P
R
I
V
R
L
K
G
F
Y
E
D
T
E
S
Y
Y
M
V
M
E
F
V
S
G
G
D
L
M
D
F
V
A
A
H
G
A
V
G
E
---
D
A
G
R
E
I
S
R
Q
I
L
T
A
I
K
Y
I
H
S
M
G
I
S
H
R
D
L
K
P
D
N
I
L
---
I
---
E
Q
D
---
D
PV--
L
---
V
K
I
T
D
F
G
L
---------------------
T
F
-
C
G
T
L
A
Y
V
A
P
E
V
I
----------------
R
N
EYSSL
V
D
M
W
S
M
G
C
L
V
Y
V
I
L
T
G
H
L
P
F
S
G
--
S
T
Q
D
-
Q
L
Y
K
Q
I
G
--
R
G
--
S
Y
H
EGP
L
--
K
----
D
----
F
R-
I
S
-------
E
E
-------
A
R
D
F
----
I
D
S
L
L
Q
V
D
P
N
N
R
S
-----
T
A
A
K
A
L
N
H
P
W
I
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
261
Blastp_CBE
51.15
34%
-77
- C2 -
-
2QHN
4.9
-
CHK1_HUMAN
A:
[5-265]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
-----------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
455
Blastp_CBE
51.11
34%
-83
- C2 -
-
3PA5
6.4
-
CHK1_HUMAN
A:
[4-264]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
--
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
----
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
353
Blastp_CBE
51.13
34%
-76
- C2 -
-
1NVS
7.1
-
CHK1_HUMAN
A:
[5-265]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
-----------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
280
Blastp_CBE
51.12
33%
-17
- C2 -
-
2F7Z
7.3
-
KAPCA_BOVIN
E:
[35-298]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
--
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
147
Blastp_CBE
51.11
38%
-70
- C2 -
-
3LIJ
3.9
-
?
A:
[39-300]
--------------------------
Y
Q
R
V
K
K
L
G
S
---
G
E
V
L
L
C
R
D
K
V
T
H
V
E
R
A
I
K
I
--
I
R
K
------------
S
----
S
-
N
---
S
K
L
L
---
E
E
V
A
V
L
K
L
L
D
-
H
P
N
I
M
K
L
Y
D
F
F
E
D
K
R
N
Y
Y
L
V
M
E
C
Y
K
G
G
E
L
F
D
E
I
I
H
R
M
K
F
N
E
---
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
E
----
K
DAL
I
K
I
V
D
F
G
L
-
S
-
A
-
V
---
F
E
-
N
--
Q
-
K
K
M
K
E
R
-
L
G
T
A
Y
Y
I
A
P
E
V
L
--
R
-
K
K
Y
D
--------
E
K
-----
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
G
G
--
Q
T
D
Q
-
E
I
L
R
K
V
E
--
K
G
KY
T
F
D
---
S
--
P
----
E
----
W
KN
V
S
-------
E
G
-------
A
K
D
L
----
I
K
Q
M
L
Q
F
D
S
Q
R
R
I
-----
S
A
Q
Q
A
L
E
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
231
Blastp_CBE
51.09
37%
-93
- C2 -
-
4BDH
3.6
-
CHK2_HUMAN
A:
[18-283]
--------------------------
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
------------------------
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
G
-
E
--
T
-
S
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
--
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
--
S
G
--
K
Y
------------
N
----
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
435
Blastp_CBE
51.08
34%
-80
- C2 -
-
4FTR
7.5
-
CHK1_HUMAN
A:
[4-264]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
--
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
-------------------------
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
274
Blastp_CBE
51.01
37%
-87
- C2 -
-
2YCQ
8.2
-
CHK2_HUMAN
A:
[12-277]
--------------------------
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
------------------------
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
G
-
E
--
T
-
S
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
--
V
S
V
G
T
A
-----
G
YN
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
--
S
G
--
K
Y
------------
N
----
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
341
Blastp_CBE
51.00
34%
-79
- C2 -
-
2XEZ
5.2
-
CHK1_HUMAN
A:
[7-265]
------------------------
E
D
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
378
Blastp_CBE
50.97
34%
-75
- C2 -
-
4RVM
7.4
-
CHK1_HUMAN
A:
[5-265]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
-----------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
262
Blastp_CBE
50.94
34%
-76
- C2 -
-
2QHM
5.1
-
CHK1_HUMAN
A:
[5-265]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
-----------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
279
Blastp_CBE
50.80
33%
-16
- C2 -
-
2OH0
5.8
-
KAPCA_BOVIN
E:
[35-298]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
--
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
336
Blastp_CBE
50.78
34%
-83
- C2 -
-
2YM5
5.7
-
CHK1_HUMAN
A:
[8-265]
-------------------------
D
W
D
L
V
Q
T
L
G
-----
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
379
Blastp_CBE
50.77
34%
-80
- C2 -
-
4RVL
6.8
-
CHK1_HUMAN
A:
[5-265]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
------
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
K
-----------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
440
Blastp_CBE
50.73
34%
-77
- C2 -
-
4FTJ
7.0
-
CHK1_HUMAN
A:
[4-264]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
---------------------------
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
458
Blastp_CBE
50.66
34%
-84
- C2 -
-
3OT8
8.0
-
CHK1_HUMAN
A:
[4-264]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
---
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-----
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
345
Blastp_CBE
50.65
34%
-80
- C2 -
-
2WMX
5.2
-
CHK1_HUMAN
A:
[7-265]
------------------------
E
D
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
359
Blastp_CBE
50.40
34%
-77
- C2 -
-
4FSN
7.8
-
CHK1_HUMAN
A:
[1-263]
--------------------
A
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
-
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
M
-----------------------
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
447
Blastp_CBE
50.39
34%
-81
- C2 -
-
4FSQ
8.9
-
CHK1_HUMAN
A:
[4-264]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
---------------------------
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
238
Blastp_CBE
50.24
37%
-86
- C2 -
-
4BDA
4.7
-
CHK2_HUMAN
A:
[18-283]
--------------------------
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
------------------------
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
--
E
--
T
-
S
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
--
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
--
S
G
--
K
Y
------------
N
----
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
352
Blastp_CBE
50.18
34%
-73
- C2 -
-
2WMQ
3.0
-
CHK1_HUMAN
A:
[7-265]
------------------------
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
-------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
--------
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
333
Blastp_CBE
50.18
34%
-81
- C2 -
-
2YM8
6.3
-
CHK1_HUMAN
A:
[8-265]
-------------------------
D
W
D
L
V
Q
T
L
G
-----
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
--------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
437
Blastp_CBE
50.12
34%
-81
- C2 -
-
4FTM
8.2
-
CHK1_HUMAN
A:
[4-264]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
--------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
334
Blastp_CBE
50.06
34%
-81
- C2 -
-
2YM7
5.1
-
CHK1_HUMAN
A:
[7-265]
------------------------
E
D
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
--------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
516
Blastp_CBE
49.87
36%
-89
- C2 -
-
3ZXT
5.9
-
DAPK1_HUMAN
A:
[13-274]
--------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
R
-
T
---------------
R
---
E
D
I
E
---
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
---
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
R
----VPKP
R
---
I
K
I
I
D
F
G
L
-
A
H
K
-
I
---
D
------------------
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
--
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
--
D
T
K
Q
-
E
T
L
A
N
V
S
--
A
V
--
N
Y
E
---
F
--
E
----
D
----
E
--
Y
F
-------
S
N
-------
T
S
A
L
AKDF
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
271
Blastp_CBE
49.85
37%
-87
- C2 -
-
2YIR
8.7
-
CHK2_HUMAN
A:
[12-277]
--------------------------
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
-----------------------
L
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
G
-
E
--
T
-
S
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
--
V
S
V
G
T
A
-----
G
YN
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
--
S
G
--
K
Y
------------
N
----
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
337
Blastp_CBE
49.82
34%
-78
- C2 -
-
2YM4
4.8
-
CHK1_HUMAN
A:
[5-265]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
--------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
------
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
424
Blastp_CBE
49.64
33%
-30
- C2 -
-
3MVJ
4.9
-
KAPCA_HUMAN
E:
[55-318]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
244
Blastp_CBE
49.63
37%
-101
- C2 -
-
2XM8
6.5
-
CHK2_HUMAN
A:
[18-283]
--------------------------
Y
I
M
S
K
T
L
-----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-----------------------------
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
-----
T
-
S
L
M
R
T
L
-
C
G
---
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
--
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
--
S
G
--
K
Y
------------
N
----
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
207
Blastp_CBE
49.57
35%
-1
- C2 -
-
2Y7J
5.5
-
PHKG2_HUMAN
C:
[87-363]
---------
A
A
A
--------
K
E
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
ME
V
T
A
E
R
-
L
-
S
PEQL-
E
E
----
V
-
R
---
E
A
T
R
---
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
A
L
S
E
---
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
---
D
D
N
---
M
----
Q
---
I
R
L
S
D
F
G
F
-
S
-
C
H
L
---
E
P
-
G
--
E
-
K
L
R
E
L
--
C
G
T
P
G
Y
L
A
P
E
I
L
--
K
C
S
M
D
E
THPGY
G
--
K
E
-----
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
--
R
R
Q
I
-
L
M
L
R
M
I
M
--
E
G
--
Q
Y
------------
Q
----
F
--
S
S
-------
P
E
WDDRSST
V
K
D
L
----
I
S
R
L
L
Q
V
D
P
E
A
R
L
-----
T
A
E
Q
A
L
Q
H
P
F
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
272
Blastp_CBE
49.55
37%
-88
- C2 -
-
2YIQ
7.7
-
CHK2_HUMAN
A:
[12-277]
--------------------------
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
-------------------------
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
G
-
E
--
T
-
S
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
--
V
S
V
G
T
A
-----
G
YN
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
--
S
G
--
K
Y
------------
N
----
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
146
Blastp_CBE
49.53
37%
-24
- C2 -
-
6T6F
6.3
-
?
A:
[16-289]
--------------------------
F
E
F
K
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
--
I
P
K
K
A
-
L
-
K
GK---
E
S
-----------
S
I
E
---
N
E
I
A
V
L
R
K
I
K
-
H
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
---
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
---
Y
YSQ
D
E
E
---
S
----
K
---
I
M
I
S
D
F
G
L
-
S
-------------------------
P
G
Y
V
A
P
E
V
L
--
A
Q
K
P
Y
------
S
--
K
A
-----
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
--
E
N
D
S
-
K
L
F
E
Q
I
L
--
K
A
--
E
Y
E
---
F
DS
P
----
Y
----
W
DD
I
S
-------
D
S
-------
A
K
D
F
----
I
R
N
L
M
E
K
D
P
N
K
R
Y
-----
T
C
E
Q
A
A
R
H
P
W
I
A
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
285
Blastp_CBE
49.44
36%
-36
- C2 -
-
5VJA
5.8
-
DAPK3_HUMAN
D:
[7-268]
--------------------------
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
--
I
K
K
R
R
-
L
-
S
-------V---
S
-
R
---
E
E
I
E
---
R
E
V
N
I
L
R
E
I
R
-
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
---
E
K
E
S
L
T
E
---
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
-----VPNP
R
---
I
K
L
I
D
F
G
I
-
A
H
K
-
I
---
E
A
-
G
--
N
-
E
-
F
K
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
--
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
--
E
T
K
Q
-
E
T
L
T
N
I
S
AV
N
Y
--
D
F
D
---
E
--
E
----
Y
----
F
--
S
N
-------
T
S
EL-----
A
K
D
F
----
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
T
I
A
Q
S
L
E
H
S
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
145
Blastp_CBE
49.38
37%
-16
- C2 -
-
6T6F
5.8
-
?
B:
[16-289]
--------------------------
F
E
F
K
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
--
I
P
K
K
A
-
L
-
K
GK---
E
S
-----------
S
I
E
---
N
E
I
A
V
L
R
K
I
K
-
H
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
---
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
---
Y
YSQ
D
E
E
---
S
----
K
---
I
M
I
S
D
F
G
----------------------------
P
G
Y
V
A
P
E
V
L
--
A
Q
K
P
Y
------
S
--
K
A
-----
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
--
E
N
D
S
-
K
L
F
E
Q
I
L
--
K
A
--
E
Y
E
---
F
DS
P
----
Y
----
W
DD
I
S
-------
D
S
-------
A
K
D
F
----
I
R
N
L
M
E
K
D
P
N
K
R
Y
-----
T
C
E
Q
A
A
R
H
P
W
I
A
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
340
Blastp_CBE
49.30
34%
-83
- C2 -
-
2XF0
6.0
-
CHK1_HUMAN
A:
[5-265]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
-------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
436
Blastp_CBE
48.91
34%
-82
- C2 -
-
4FTO
6.7
-
CHK1_HUMAN
A:
[4-264]
----------------------
F
V
E
D
W
D
L
V
Q
T
L
G
----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
-------------------------
E
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
----
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
250
Blastp_CBE
48.81
37%
-95
- C2 -
-
2CN8
5.1
-
CHK2_HUMAN
A:
[18-283]
--------------------------
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
------------------------
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
-----
T
-
S
L
M
R
T
L
-
C
--
P
T
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
--
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
---V
S
L
K
D
Q
I
T
--
S
G
--
K
Y
------------
N
----
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
350
Blastp_CBE
48.56
34%
-78
- C2 -
-
2WMS
4.1
-
CHK1_HUMAN
A:
[7-265]
------------------------
E
D
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
-----------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-----
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
348
Blastp_CBE
48.55
34%
-83
- C2 -
-
2WMU
4.2
-
CHK1_HUMAN
A:
[9-265]
--------------------------
W
D
L
V
Q
T
L
G
E
-----
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
-------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
325
Blastp_CBE
48.37
33%
-30
- C2 -
-
1VEB
6.8
-
KAPCA_BOVIN
A:
[34-297]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
395
Blastp_CBE
48.32
33%
-26
- C2 -
-
1CDK
8.3
-
KAPCA_PIG
A:
[34-297]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
F
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
Y
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
329
Blastp_CBE
48.19
33%
-28
- C2 -
-
1Q8U
6.0
-
KAPCA_BOVIN
A:
[34-297]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
338
Blastp_CBE
48.18
34%
-80
- C2 -
-
2YM3
4.8
-
CHK1_HUMAN
A:
[8-265]
-------------------------
D
W
D
L
V
Q
T
L
G
-----
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
--
V
D
-------------------------
N
I
K
---
K
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
---
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
-
A
-
T
-
V
FRY
N
N
-
R
--
E
-
R
L
L
N
K
M
-
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
F
H
-----
A
--
E
P
-----
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
PS
D
S
C
Q
-
E
Y
S
D
W
K
E
--
K
K
--
T
Y
L
---
N
--
P
----
W
K---
K
--
I
D
-------
S
A
-------
P
L
A
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
411
Blastp_CBE
48.07
33%
-33
- C2 -
-
3L9L
6.7
-
KAPCA_HUMAN
B:
[35-298]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
310
Blastp_CBE
47.94
33%
-28
- C2 -
-
2VO7
7.8
-
KAPCA_BOVIN
A:
[35-298]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
299
Blastp_CBE
47.94
33%
-25
- C2 -
-
4IJ9
6.6
-
KAPCA_BOVIN
A:
[34-297]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
394
Blastp_CBE
47.91
33%
-27
- C2 -
-
1CDK
7.8
-
KAPCA_PIG
B:
[34-297]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
F
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
Y
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
466
Blastp_CBE
47.85
33%
-26
- C2 -
-
1XH9
7.3
-
KAPCA_BOVIN
A:
[34-297]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
E
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
T
D
F
G
L
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
328
Blastp_CBE
47.82
33%
-32
- C2 -
-
1STC
8.3
-
KAPCA_BOVIN
E:
[34-297]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
311
Blastp_CBE
47.74
33%
-28
- C2 -
-
2C1B
6.5
-
KAPCA_BOVIN
A:
[35-298]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
307
Blastp_CBE
47.73
33%
-24
- C2 -
-
4IE9
4.5
-
KAPCA_BOVIN
A:
[35-298]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
406
Blastp_CBE
47.69
33%
-29
- C2 -
-
3P0M
5.9
-
KAPCA_HUMAN
A:
[35-298]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
520
Blastp_CBE
47.67
33%
-27
- C2 -
-
3L9M
5.6
-
KAPCA_HUMAN
A:
[35-298]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
409
Blastp_CBE
47.64
33%
-24
- C2 -
-
3OVV
6.6
-
KAPCA_HUMAN
A:
[35-298]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
215
Blastp_CBE
47.64
33%
-26
- C2 -
-
2GNL
5.6
-
KAPCA_BOVIN
A:
[34-297]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
A
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
305
Blastp_CBE
47.58
33%
-31
- C2 -
-
6E9L
6.9
-
KAPCA_BOVIN
A:
[35-298]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
297
Blastp_CBE
47.53
33%
-26
- C2 -
-
3DNE
4.9
-
KAPCA_BOVIN
A:
[34-297]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
518
Blastp_CBE
47.44
33%
-29
- C2 -
-
3L9N
4.5
-
KAPCA_HUMAN
A:
[35-301]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
519
Blastp_CBE
47.46
33%
-29
- C2 -
-
3L9M
6.0
-
KAPCA_HUMAN
B:
[35-298]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
330
Blastp_CBE
47.44
33%
-25
- C2 -
-
1Q8T
4.5
-
KAPCA_BOVIN
A:
[34-297]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
432
Blastp_CBE
47.38
33%
-25
- C2 -
-
3AGL
7.2
-
KAPCA_HUMAN
A:
[35-298]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
408
Blastp_CBE
47.40
33%
-25
- C2 -
-
3OWP
5.7
-
KAPCA_HUMAN
A:
[35-298]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
407
Blastp_CBE
47.38
33%
-19
- C2 -
-
3OXT
5.6
-
KAPCA_HUMAN
A:
[35-298]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
513
Blastp_CBE
47.35
36%
-58
- C2 -
-
3ZXT
4.3
-
DAPK1_HUMAN
D:
[13-274]
--------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
---------------V---
S
-
R
---
E
D
I
E
---
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
----
T
E
---
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
-
A
H
K
-
I
---
D
----------------
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
--
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
--
D
T
K
Q
-
E
T
L
A
N
V
S
--
A
V
--
N
Y
E
---
F
--
E
----
D
----
E
--
Y
F
-------
S
N
-------
T
S
A
L
AKDF
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
413
Blastp_CBE
47.33
33%
-26
- C2 -
-
3AGM
6.2
-
KAPCA_HUMAN
A:
[35-298]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
410
Blastp_CBE
47.30
33%
-28
- C2 -
-
3OOG
4.3
-
KAPCA_HUMAN
A:
[35-298]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
450
Blastp_CBE
47.23
33%
-30
- C2 -
-
2GNI
5.3
-
KAPCA_BOVIN
A:
[34-297]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
A
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
327
Blastp_CBE
47.25
33%
-29
- C2 -
-
1SVE
6.9
-
KAPCA_BOVIN
A:
[34-297]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
506
Blastp_CBE
47.24
33%
-29
- C2 -
-
1Q24
6.5
-
KAPCA_BOVIN
A:
[34-297]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
216
Blastp_CBE
47.23
33%
-30
- C2 -
-
2GNJ
5.3
-
KAPCA_BOVIN
A:
[34-297]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
A
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
541
Blastp_CBE
47.21
33%
-20
- C2 -
-
2UW4
3.8
-
KAPCA_BOVIN
A:
[35-298]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
-
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
412
Blastp_CBE
47.15
33%
-30
- C2 -
-
3L9L
6.8
-
KAPCA_HUMAN
A:
[35-298]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
449
Blastp_CBE
47.11
33%
-30
- C2 -
-
2GNF
4.9
-
KAPCA_BOVIN
A:
[34-297]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
A
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
295
Blastp_CBE
47.11
33%
-24
- C2 -
-
4YXS
4.3
-
KAPCA_BOVIN
A:
[34-297]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
431
Blastp_CBE
47.08
33%
-23
- C2 -
-
3AGL
8.0
-
KAPCA_HUMAN
B:
[35-298]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
245
Blastp_CBE
47.10
37%
-30
- C2 -
-
2XBJ
7.5
-
CHK2_HUMAN
A:
[18-283]
--------------------------
Y
I
M
S
K
T
L
G
S
G
A
-
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
--------------------A--
L
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
-----
T
-
S
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
--
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
--
S
G
--
K
Y
------------
N
----
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
405
Blastp_CBE
47.06
33%
-25
- C2 -
-
3POO
7.2
-
KAPCA_HUMAN
A:
[35-302]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
326
Blastp_CBE
47.05
33%
-29
- C2 -
-
1SVG
7.9
-
KAPCA_BOVIN
A:
[34-297]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
301
Blastp_CBE
47.06
33%
-24
- C2 -
-
1XH8
8.8
-
KAPCA_BOVIN
A:
[34-297]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
298
Blastp_CBE
47.05
33%
-29
- C2 -
-
3DND
4.1
-
KAPCA_BOVIN
A:
[34-297]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
417
Blastp_CBE
47.02
33%
-23
- C2 -
-
4WB6
8.2
-
KAPCA_HUMAN
B:
[34-297]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
R
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
396
Blastp_CBE
47.01
33%
-26
- C2 -
-
5UZK
8.3
-
KAPCA_HUMAN
A:
[35-298]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
257
Blastp_CBE
46.94
35%
-46
- C2 -
-
4JXF
3.4
-
PLK4_HUMAN
A:
[6-259]
-----------------------
I
E
D
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
--
I
D
K
K
A
-
M
-
Y
-----
K
A
G---
M
-
V
---
Q
R
V
Q
---
N
E
V
K
I
H
C
Q
L
K
-
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
--
K
N
R
V
K
P
FSE
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
I
L
H
R
D
L
T
L
S
N
L
L
---
L
---
T
R
N
---
M
----
N
---
I
K
I
A
D
F
G
L
-
A
-
T
Q
L
---
K
M
-
P
--
H
-------------------------------------
E
-----
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
------
V
K
-
N
T
L
N
K
V
V
--
L
A
--
D
Y
E
---
M
--
P
----
S
----
F
--
L
S
-------
I
E
-------
A
K
D
L
----
I
H
Q
L
L
R
R
N
P
A
D
R
L
-----
S
L
S
S
V
L
D
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
213
Blastp_CBE
46.93
33%
-31
- C2 -
-
1YDS
4.6
-
KAPCA_BOVIN
E:
[34-297]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
304
Blastp_CBE
46.90
33%
-23
- C2 -
-
1SVH
7.8
-
KAPCA_BOVIN
A:
[34-297]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
534
Blastp_CBE
46.86
34%
-31
- C2 -
-
1REJ
6.4
-
KAPCA_MOUSE
A:
[47-297]
------------------------------
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
485
Blastp_CBE
46.85
33%
-25
- C2 -
-
4Z83
6.7
-
KAPCA_BOVIN
E:
[34-297]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
551
Blastp_CBE
46.84
36%
19
- C2 -
-
5AV3
5.3
-
DAPK1_HUMAN
A:
[13-274]
--------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
R
-
T
-
K
-----
S
S
RRGV
S
-
R
---
E
D
I
E
---
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-
S
L
T
E
---
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
-
A
H
K
-
I
---
D
F
-
G
--
N
-
E
-
F
K
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
--
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
--
D
T
K
Q
-
E
T
L
A
N
V
S
--
A
V
--
N
Y
E
---
F
--
E
----
D
----
E
--
Y
F
-------
S
N
-------
T
S
A
L
AKDF
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
214
Blastp_CBE
46.82
33%
-29
- C2 -
-
1YDR
5.1
-
KAPCA_BOVIN
E:
[34-297]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
426
Blastp_CBE
46.79
33%
-26
- C2 -
-
3MVJ
4.9
-
KAPCA_HUMAN
A:
[55-318]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
212
Blastp_CBE
46.81
33%
-28
- C2 -
-
1YDT
6.0
-
KAPCA_BOVIN
E:
[34-297]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
415
Blastp_CBE
46.79
33%
-24
- C2 -
-
6C0U
7.1
-
KAPCA_HUMAN
A:
[38-301]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
158
Blastp_CBE
46.77
36%
11
- C2 -
-
3HX4
4.4
-
?
A:
[41-308]
---------
V
Q
H
ST------
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
------DK---
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
--------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
-
D
I
L
K
K
V
E
--
K
G
KY
T
F
E
---
L
--
P
----
Q
----
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
451
Blastp_CBE
46.71
33%
-27
- C2 -
-
2GNH
5.8
-
KAPCA_BOVIN
A:
[34-297]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
A
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
543
Blastp_CBE
46.67
33%
-29
- C2 -
-
2JDV
6.3
-
KAPCA_BOVIN
A:
[35-298]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
430
Blastp_CBE
46.63
33%
-22
- C2 -
-
3VQH
6.7
-
KAPCA_HUMAN
A:
[35-298]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
155
Blastp_CBE
46.63
36%
4
- C2 -
-
4IH8
5.1
-
?
A:
[45-335]
--------------------
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
-----
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
--------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
-
D
I
L
K
K
V
E
--
K
G
KY
T
F
E
---
L
--
P
----
Q
----
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
428
Blastp_CBE
46.61
33%
-23
- C2 -
-
5BX6
3.3
-
KAPCA_HUMAN
A:
[35-298]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
309
Blastp_CBE
46.60
33%
-24
- C2 -
-
3AG9
7.9
-
KAPCA_BOVIN
B:
[35-315]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
403
Blastp_CBE
46.59
33%
-23
- C2 -
-
4UJ2
6.1
-
KAPCA_HUMAN
A:
[35-298]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
303
Blastp_CBE
46.58
33%
-27
- C2 -
-
1XH5
8.4
-
KAPCA_BOVIN
A:
[34-297]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
552
Blastp_CBE
46.50
36%
21
- C2 -
-
5AV2
5.1
-
DAPK1_HUMAN
A:
[13-274]
--------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
R
-
T
-
K
-----
S
S
RRGV
S
-
R
---
E
D
I
E
---
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-
S
L
T
E
---
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
-
A
H
K
-
I
---
D
F
-
G
--
N
-
E
-
F
K
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
--
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
--
D
T
K
Q
-
E
T
L
A
N
V
S
--
A
V
--
N
Y
E
---
F
--
E
----
D
----
E
--
Y
F
-------
S
N
-------
T
S
A
L
AKDF
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
404
Blastp_CBE
46.49
33%
-25
- C2 -
-
4UJ1
5.4
-
KAPCA_HUMAN
A:
[35-298]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
234
Blastp_CBE
46.46
37%
-42
- C2 -
-
4BDE
4.4
-
CHK2_HUMAN
A:
[18-283]
--------------------------
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
--------------------A--
L
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
-----
T
-
S
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
--
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
--
S
G
--
K
Y
------------
N
----
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
487
Blastp_CBE
46.44
33%
-26
- C2 -
-
4Z84
5.8
-
KAPCA_BOVIN
A:
[35-298]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
306
Blastp_CBE
46.42
33%
-27
- C2 -
-
6E99
7.2
-
KAPCA_BOVIN
A:
[35-298]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
530
Blastp_CBE
46.37
34%
-30
- C2 -
-
3IDC
5.7
-
KAPCA_MOUSE
A:
[47-297]
------------------------------
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
550
Blastp_CBE
46.32
36%
13
- C2 -
-
5AV4
5.5
-
DAPK1_HUMAN
A:
[13-274]
--------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
R
-
T
-
K
-----
S
S
RRGV
S
-
R
---
E
D
I
E
---
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
--
E
S
L
T
E
---
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
-
A
H
K
-
I
---
D
F
-
G
--
N
-
E
-
F
K
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
--
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
--
D
T
K
Q
-
E
T
L
A
N
V
S
--
A
V
--
N
Y
E
---
F
--
E
----
D
----
E
--
Y
F
-------
S
N
-------
T
S
A
L
AKDF
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
312
Blastp_CBE
46.35
33%
-26
- C2 -
-
2C1A
6.3
-
KAPCA_BOVIN
A:
[35-298]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
296
Blastp_CBE
46.33
33%
-25
- C2 -
-
4YXR
3.7
-
KAPCA_BOVIN
A:
[34-297]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
288
Blastp_CBE
46.32
36%
19
- C2 -
-
5VJA
5.6
-
DAPK3_HUMAN
A:
[7-268]
--------------------------
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
--
I
K
K
R
------------RRGV
S
-
R
---
E
E
I
E
---
R
E
V
N
I
L
R
E
I
R
-
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
---
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
K
---
N
VPNP
R
---
I
K
L
I
D
F
G
I
-
A
H
K
-
I
---
E
A
-
G
--
N
-
E
-
F
K
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
--
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
--
E
T
K
Q
-
E
T
L
T
N
I
S
AV
N
Y
--
D
F
D
---
E
--
E
----
Y
----
F
--
S
N
-------
T
S
EL-----
A
K
D
F
----
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
T
I
A
Q
S
L
E
H
S
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
228
Blastp_CBE
46.32
37%
-40
- C2 -
-
4BDK
4.4
-
CHK2_HUMAN
A:
[18-283]
--------------------------
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
--------------------A--
L
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
G
-
E
--
T
-
S
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
--
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
--
S
G
--
K
Y
------------
N
----
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
401
Blastp_CBE
46.31
33%
-23
- C2 -
-
4UJA
6.9
-
KAPCA_HUMAN
A:
[35-298]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
526
Blastp_CBE
46.28
34%
-29
- C2 -
-
4HPT
5.9
-
KAPCA_MOUSE
E:
[47-297]
------------------------------
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
179
Blastp_CBE
46.22
36%
16
- C2 -
-
4TZR
6.7
-
?
A:
[19-289]
-----------
H
ST------
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
--------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
-
D
I
L
K
K
V
E
--
K
G
KY
T
F
E
---
L
--
P
----
Q
----
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
302
Blastp_CBE
46.19
33%
-23
- C2 -
-
1XH6
8.6
-
KAPCA_BOVIN
A:
[34-297]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
287
Blastp_CBE
46.18
36%
16
- C2 -
-
5VJA
5.6
-
DAPK3_HUMAN
B:
[7-268]
--------------------------
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
--
I
K
K
-------------RRGV
S
-
R
---
E
E
I
E
---
R
E
V
N
I
L
R
E
I
R
-
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
---
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
K
---
N
VPNP
R
---
I
K
L
I
D
F
G
I
-
A
H
K
-
I
---
E
A
-
G
--
N
-
E
-
F
K
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
--
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
--
E
T
K
Q
-
E
T
L
T
N
I
S
AV
N
Y
--
D
F
D
---
E
--
E
----
Y
----
F
--
S
N
-------
T
S
EL-----
A
K
D
F
----
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
T
I
A
Q
S
L
E
H
S
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
537
Blastp_CBE
46.15
34%
-32
- C2 -
-
1FMO
4.9
-
KAPCA_MOUSE
E:
[47-297]
------------------------------
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
545
Blastp_CBE
46.13
33%
-21
- C2 -
-
2VO0
6.6
-
KAPCA_BOVIN
A:
[35-298]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
308
Blastp_CBE
46.11
33%
-22
- C2 -
-
3ZO4
7.1
-
KAPCA_BOVIN
A:
[35-298]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
542
Blastp_CBE
46.06
33%
-22
- C2 -
-
2UVX
3.9
-
KAPCA_BOVIN
A:
[35-298]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
531
Blastp_CBE
46.06
34%
-33
- C2 -
-
3IDB
6.2
-
KAPCA_MOUSE
A:
[47-297]
------------------------------
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
544
Blastp_CBE
46.00
33%
-20
- C2 -
-
2JDT
5.9
-
KAPCA_BOVIN
A:
[35-298]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
517
Blastp_CBE
45.98
36%
18
- C2 -
-
2YAK
9.5
-
DAPK1_HUMAN
A:
[13-274]
--------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
R
-
T
-
K
-----
S
S
RRGV
S
-
R
---
E
D
I
E
---
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
---
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
-
A
H
K
-
I
---
D
F
-
G
--
N
-
E
-
F
K
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
--
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
--
D
T
K
Q
-
E
T
L
A
N
V
S
--
A
V
--
N
Y
E
---
F
--
E
----
D
----
E
--
Y
F
-------
S
N
-------
T
S
A
L
AKDF
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
509
Blastp_CBE
45.96
34%
-28
- C2 -
-
2GU8
7.2
-
KAPCA_HUMAN
A:
[34-284]
------------------------------
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
E
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
427
Blastp_CBE
45.93
33%
-23
- C2 -
-
5BX7
3.9
-
KAPCA_HUMAN
A:
[35-298]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
539
Blastp_CBE
45.83
33%
-23
- C2 -
-
4AXA
6.7
-
KAPCA_BOVIN
A:
[35-298]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
185
Blastp_CBE
45.82
36%
14
- C2 -
-
3V51
7.8
-
?
A:
[20-290]
------------ST------
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
--------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
-
D
I
L
K
K
V
E
--
K
G
KY
T
F
E
---
L
--
P
----
Q
----
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
230
Blastp_CBE
45.80
37%
-29
- C2 -
-
4BDI
4.2
-
CHK2_HUMAN
A:
[18-283]
--------------------------
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
--------------------A--
L
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
G
-
E
--
T
-
S
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
--
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
--
S
G
--
K
Y
------------
N
----
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
429
Blastp_CBE
45.73
33%
-22
- C2 -
-
4UJB
6.5
-
KAPCA_HUMAN
A:
[35-298]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
294
Blastp_CBE
45.68
36%
15
- C2 -
-
3BHY
5.2
-
DAPK3_HUMAN
A:
[7-268]
--------------------------
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
--
I
K
K
R
R
-
L
-
S
-----
S
S
RRGV
S
-
R
---
E
E
I
E
---
R
E
V
N
I
L
R
E
I
R
-
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
---
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
K
---
N
VPNP
R
---
I
K
L
I
D
F
G
I
-
A
H
K
-
I
---
E
--------------
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
--
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
--
E
T
K
Q
-
E
T
L
T
N
I
S
AV
N
Y
--
D
F
D
---
E
--
E
----
Y
----
F
--
S
N
-------
T
S
EL-----
A
K
D
F
----
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
T
I
A
Q
S
L
E
H
S
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
533
Blastp_CBE
45.62
34%
-23
- C2 -
-
1REK
8.8
-
KAPCA_MOUSE
A:
[47-297]
------------------------------
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
507
Blastp_CBE
45.59
36%
22
- C2 -
-
2W4K
5.2
-
DAPK1_HUMAN
A:
[13-274]
--------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
R
-
T
-
K
-----
S
S
RRGV
S
-
R
---
E
D
I
E
---
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
---
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
-
A
H
K
-
I
---
D
F
-
G
--
N
-
E
-
F
K
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
--
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
--
D
T
K
Q
-
E
T
L
A
N
V
S
--
A
V
--
N
Y
E
---
F
--
E
----
D
----
E
--
Y
F
-------
S
N
-------
T
S
A
L
AKDF
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
183
Blastp_CBE
45.58
36%
12
- C2 -
-
3V5T
6.1
-
?
A:
[20-289]
------------ST------
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
--------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
-
D
I
L
K
K
V
E
--
K
G
KY
T
F
E
---
L
--
P
----
Q
----
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
528
Blastp_CBE
45.54
34%
-26
- C2 -
-
3OW3
4.7
-
KAPCA_MOUSE
A:
[47-297]
------------------------------
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
217
Blastp_CBE
45.53
35%
-43
- C2 -
-
3COK
5.1
-
PLK4_HUMAN
B:
[10-263]
-----------------------
I
E
D
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
--
I
D
K
K
A
-
M
-
Y
-----
K
A
G---
M
-
V
---
Q
R
V
Q
---
N
E
V
K
I
H
C
Q
L
K
-
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
--
K
N
R
V
K
P
FSE
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
I
L
H
R
D
L
T
L
S
N
L
L
---
L
---
T
R
N
---
M
----
N
---
I
K
I
A
D
F
G
L
-
A
-
T
Q
L
---
K
------------------------------------------
L
E
-----
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
---------
N
T
L
N
K
V
V
--
L
A
--
D
Y
E
---
M
--
P
----
S
----
F
--
L
S
-------
I
E
-------
A
K
D
L
----
I
H
Q
L
L
R
R
N
P
A
D
R
L
-----
S
L
S
S
V
L
D
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
218
Blastp_CBE
45.49
35%
-41
- C2 -
-
3COK
6.0
-
PLK4_HUMAN
A:
[10-263]
-----------------------
I
E
D
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
--
I
D
K
K
A
-
M
-
Y
-----
K
A
G---
M
-
V
---
Q
R
V
Q
---
N
E
V
K
I
H
C
Q
L
K
-
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
--
K
N
R
V
K
P
FSE
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
I
L
H
R
D
L
T
L
S
N
L
L
---
L
---
T
R
N
---
M
----
N
---
I
K
I
A
D
F
G
L
-
A
-
T
Q
L
---
K
-------------------------------------------
E
-----
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
D
T
--
D
T
V
------
K
V
V
--
L
A
--
D
Y
E
---
M
--
P
----
S
----
F
--
L
S
-------
I
E
-------
A
K
D
L
----
I
H
Q
L
L
R
R
N
P
A
D
R
L
-----
S
L
S
S
V
L
D
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
483
Blastp_CBE
45.46
33%
-20
- C2 -
-
1XHA
8.1
-
KAPCA_BOVIN
A:
[34-297]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
E
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
L
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
492
Blastp_CBE
45.45
34%
-34
- C2 -
-
2QUR
5.6
-
KAPCA_MOUSE
A:
[47-297]
------------------------------
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLPN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
535
Blastp_CBE
45.37
34%
-29
- C2 -
-
1RE8
7.4
-
KAPCA_MOUSE
A:
[47-297]
------------------------------
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
286
Blastp_CBE
45.36
36%
13
- C2 -
-
5VJA
5.7
-
DAPK3_HUMAN
C:
[7-268]
--------------------------
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
--
I
K
K
R
R
-
L
-
S
-----
S
-GV--
S
-
R
---
E
E
I
E
---
R
E
V
N
I
L
R
E
I
R
-
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
--
E
K
E
S
L
T
E
---
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
-----VPNP
R
---
I
K
L
I
D
F
G
I
-
A
H
K
-
I
---
E
A
-
G
--
N
-
E
-
F
K
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
--
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
--
E
T
K
Q
-
E
T
L
T
N
I
S
AV
N
Y
--
D
F
D
---
E
--
E
----
Y
----
F
--
S
N
-------
T
S
EL-----
A
K
D
F
----
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
T
I
A
Q
S
L
E
H
S
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
524
Blastp_CBE
45.29
34%
-29
- C2 -
-
2ERZ
4.9
-
KAPCA_MOUSE
E:
[48-298]
------------------------------
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
157
Blastp_CBE
45.28
36%
15
- C2 -
-
3KU2
4.6
-
?
A:
[44-314]
------------T-------
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
--------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
-
D
I
L
K
K
V
E
--
K
G
KY
T
F
E
---
L
--
P
----
Q
----
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
156
Blastp_CBE
45.28
36%
15
- C2 -
-
4IFG
7.6
-
?
A:
[44-319]
------------T-------
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
--------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
-
D
I
L
K
K
V
E
--
K
G
KY
T
F
E
---
L
--
P
----
Q
----
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
525
Blastp_CBE
45.20
36%
25
- C2 -
-
6QMO
2.3
-
DAPK1_HUMAN
A:
[16-277]
--------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
R
-
T
-
K
-----
S
S
RRGV
S
-
R
---
E
D
I
E
---
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
---
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
-
A
H
K
-
I
---
D
F
-
G
--
N
-
E
-
F
K
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
--
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
--
D
T
K
Q
-
E
T
L
A
N
V
S
--
A
V
--
N
Y
E
---
F
--
E
----
D
----
E
--
Y
F
-------
S
N
-------
T
S
A
L
AKDF
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
193
Blastp_CBE
45.19
36%
18
- C2 -
-
3I7B
5.8
-
?
A:
[23-287]
---------------------
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
--------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
-
D
I
L
K
K
V
E
--
K
G
KY
T
F
E
---
L
--
P
----
Q
----
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
148
Blastp_CBE
45.18
36%
1
- C2 -
-
3MA6
5.7
-
?
B:
[29-290]
---------------------
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
-
V
-
K
QTDK-
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
--------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
-
D
I
L
K
K
V
E
--
K
G
KY
T
F
E
---
L
--
P
----
Q
----
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
182
Blastp_CBE
45.10
36%
13
- C2 -
-
4JBV
5.9
-
?
A:
[22-289]
--------------------
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
--------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
-
D
I
L
K
K
V
E
--
K
G
KY
T
F
E
---
L
--
P
----
Q
----
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
538
Blastp_CBE
45.05
34%
-28
- C2 -
-
1ATP
8.2
-
KAPCA_MOUSE
E:
[47-297]
------------------------------
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
540
Blastp_CBE
45.04
33%
-24
- C2 -
-
2UW7
5.8
-
KAPCA_BOVIN
A:
[35-298]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
175
Blastp_CBE
44.98
36%
16
- C2 -
-
4YJN
6.0
-
?
A:
[20-289]
------------ST------
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
--------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
-
D
I
L
K
K
V
E
--
K
G
KY
T
F
E
---
L
--
P
----
Q
----
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
527
Blastp_CBE
44.89
34%
-22
- C2 -
-
4DIN
6.9
-
KAPCA_MOUSE
A:
[47-297]
------------------------------
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
220
Blastp_CBE
44.90
36%
2
- C2 -
-
4YZB
6.2
-
?
A:
[21-292]
---------
V
Q
H
ST------
A
A
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
V
T
G
Q
E
Y
A
V
K
V
--
I
S
K
R
----------
Q
K
----
T
D
K
---
E
L
L
L
---
K
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
N
K
---
R
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
S
--
T
-
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
--------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
F
-
D
I
L
K
K
V
E
--
K
G
KF
T
F
D
---
L
--
P
----
Q
----
W
KK
V
S
-------
E
P
-------
A
K
D
L
----
I
R
K
M
L
A
Y
V
P
T
M
R
I
-----
S
A
R
D
A
L
E
H
E
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
160
Blastp_CBE
44.89
36%
3
- C2 -
-
5T6I
5.3
-
?
A:
[62-359]
------------T-------
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
---
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KA--
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
--------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
-
D
I
L
K
K
V
E
--
K
G
KY
T
F
E
---
L
--
P
----
Q
----
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
184
Blastp_CBE
44.75
36%
15
- C2 -
-
3V5P
5.9
-
?
A:
[20-299]
------------ST------
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
--------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
-
D
I
L
K
K
V
E
--
K
G
KY
T
F
E
---
L
--
P
----
Q
----
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
227
Blastp_CBE
44.73
37%
4
- C2 -
-
3HZT
5.8
-
?
A:
[6-296]
--------------------------
Y
Q
R
V
K
K
L
G
S
G
A
Y
G
E
V
L
L
C
K
D
K
L
T
G
A
E
R
A
I
K
I
--
I
K
K
S
S
-
V
-
T
-----
T
T
SNSG
A
-
L
---
L
D
------
E
V
A
V
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
R
N
Y
Y
L
V
M
E
V
Y
R
G
G
E
L
F
D
E
I
I
L
R
Q
K
F
S
E
---
V
D
A
A
V
I
M
K
Q
V
L
S
G
T
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
----
R
DAL
I
K
I
V
D
F
G
L
S
A
-
H
-
F
---
E
V
--------------
G
T
A
Y
Y
I
A
P
E
V
L
--
R
-
K
K
Y
D
--------
E
K
-----
C
D
V
W
S
C
G
V
I
L
Y
I
L
L
C
G
Y
P
P
F
G
G
--
Q
T
D
Q
-
E
I
L
K
R
V
E
--
K
G
--
K
F
------------
S
----
F
--
D
P
-------
P
D
WTQVSDE
A
K
Q
L
----
V
K
L
M
L
T
Y
E
P
S
K
R
I
-----
S
A
E
E
A
L
N
H
P
W
I
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
153
Blastp_CBE
44.71
36%
33
- C2 -
-
4IEB
4.6
-
?
A:
[40-308]
---------
V
Q
H
ST------
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
-
V
--TDK--
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
M
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
--------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
-
D
I
L
K
K
V
E
--
K
G
KY
T
F
E
------
P
----
Q
----
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
211
Blastp_CBE
44.70
36%
-50
- C2 -
-
4YUR
6.2
-
PLK4_HUMAN
A:
[15-265]
--------------------------
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
--
I
D
K
K
A
-
M
-
Y
-----
K
A
G---
M
-
V
---
Q
R
V
Q
---
N
E
V
K
I
H
C
Q
L
K
-
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
--
K
N
R
V
K
P
FSE
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
I
L
H
R
D
L
T
L
S
N
L
L
---
L
---
T
R
N
---
M
----
N
---
I
K
I
A
D
F
---------------------------------------------------
G
--
L
E
-----
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
-----
T
V
K
-
N
T
L
N
K
V
V
--
L
A
--
D
Y
E
---
M
--
P
----
S
----
F
--
L
S
-------
I
E
-------
A
K
D
L
----
I
H
Q
L
L
R
R
N
P
A
D
R
L
-----
S
L
S
S
V
L
D
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
178
Blastp_CBE
44.66
36%
16
- C2 -
-
4WG3
5.3
-
?
A:
[20-289]
------------ST------
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
--------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
-
D
I
L
K
K
V
E
--
K
G
KY
T
F
E
---
L
--
P
----
Q
----
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
289
Blastp_CBE
44.63
36%
26
- C2 -
-
5A6O
3.1
-
DAPK3_HUMAN
B:
[7-268]
--------------------------
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
--
I
K
K
R
R
-
L
-
S
-----
S
S
RRGV
S
-
R
---
E
E
I
E
---
R
E
V
N
I
L
R
E
I
R
-
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
---
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
K
---
N
VPNP
R
---
I
K
L
I
D
F
G
I
-
A
H
K
-
I
---
E
----------
K
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
--
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
--
E
T
K
Q
-
E
T
L
T
N
I
S
AV
N
Y
--
D
F
D
---
E
--
E
----
Y
----
F
--
S
N
-------
T
S
EL-----
A
K
D
F
----
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
T
I
A
Q
S
L
E
H
S
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
171
Blastp_CBE
44.60
36%
16
- C2 -
-
5W9E
5.6
-
?
A:
[21-297]
------------T-------
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
--------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
-
D
I
L
K
K
V
E
--
K
G
KY
T
F
E
---
L
--
P
----
Q
----
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
532
Blastp_CBE
44.55
34%
-25
- C2 -
-
3FJQ
8.0
-
KAPCA_MOUSE
E:
[47-297]
------------------------------
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
---
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
197
Blastp_CBE
44.53
36%
19
- C2 -
-
4MX9
5.1
-
?
A:
[21-291]
------------ST------
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
Y
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
--------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
-
D
I
L
K
K
V
E
--
K
G
KY
T
F
E
---
L
--
P
----
Q
----
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
196
Blastp_CBE
44.53
36%
21
- C2 -
-
4MXA
5.1
-
?
A:
[21-291]
------------ST------
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
Y
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
--------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
-
D
I
L
K
K
V
E
--
K
G
KY
T
F
E
---
L
--
P
----
Q
----
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
180
Blastp_CBE
44.50
36%
11
- C2 -
-
4ONA
5.6
-
?
A:
[20-284]
------------ST------
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
--------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
-
D
I
L
K
K
V
E
--
K
G
KY
T
F
E
---
L
--
P
----
Q
----
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
222
Blastp_CBE
44.47
36%
8
- C2 -
-
4YUQ
5.7
-
?
A:
[21-291]
---------
V
Q
H
ST------
A
A
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
V
T
G
Q
E
Y
A
V
K
V
--
I
S
K
R
Q
----------------------
L
L
L
---
K
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
N
K
---
R
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
S
--
T
-
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
--------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
F
-
D
I
L
K
K
V
E
--
K
G
KF
T
F
D
---
L
--
P
----
Q
----
W
KK
V
S
-------
E
P
-------
A
K
D
L
----
I
R
K
M
L
A
Y
V
P
T
M
R
I
-----
S
A
R
D
A
L
E
H
E
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
149
Blastp_CBE
44.47
36%
18
- C2 -
-
3MA6
4.1
-
?
A:
[29-290]
---------------------
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
----
S
-
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
--------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
-
D
I
L
K
K
V
E
--
K
G
KY
T
F
E
---
L
--
P
----
Q
----
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
172
Blastp_CBE
44.43
36%
14
- C2 -
-
5W91
6.0
-
?
A:
[20-298]
------------ST------
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
--------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
-
D
I
L
K
K
V
E
--
K
G
KY
T
F
E
---
L
--
P
----
Q
----
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
169
Blastp_CBE
44.40
36%
17
- C2 -
-
6BFA
4.8
-
?
A:
[21-284]
------------T-------
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
--------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
-
D
I
L
K
K
V
E
--
K
G
KY
T
F
E
---
L
--
P
----
Q
----
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
546
Blastp_CBE
44.31
36%
21
- C2 -
-
6QN4
2.5
-
DAPK1_HUMAN
A:
[16-277]
--------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
R
-
T
-
K
-----
S
S
RRGV
S
-
R
---
E
D
I
E
---
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
---
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
-
A
H
K
-
I
---
D
F
-
G
--
N
-
E
-
F
K
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
--
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
--
D
T
K
Q
-
E
T
L
A
N
V
S
--
A
V
--
N
Y
E
---
F
--
E
----
D
----
E
--
Y
F
-------
S
N
-------
T
S
A
L
AKDF
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
162
Blastp_CBE
44.33
36%
13
- C2 -
-
5JN2
6.1
-
?
A:
[61-340]
------------ST------
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
--------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
-
D
I
L
K
K
V
E
--
K
G
KY
T
F
E
---
L
--
P
----
Q
----
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
173
Blastp_CBE
44.31
36%
18
- C2 -
-
5W8R
6.8
-
?
A:
[21-292]
------------T-------
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
--------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
-
D
I
L
K
K
V
E
--
K
G
KY
T
F
E
---
L
--
P
----
Q
----
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
190
Blastp_CBE
44.30
36%
21
- C2 -
-
3SXF
5.4
-
?
A:
[22-295]
--------------------
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
--------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
-
D
I
L
K
K
V
E
--
K
G
KY
T
F
E
---
L
--
P
----
Q
----
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
154
Blastp_CBE
44.30
36%
18
- C2 -
-
4IHP
5.0
-
?
A:
[44-317]
------------T-------
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
--------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
-
D
I
L
K
K
V
E
--
K
G
KY
T
F
E
---
L
--
P
----
Q
----
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
174
Blastp_CBE
44.24
36%
22
- C2 -
-
5W80
6.7
-
?
A:
[21-295]
------------T-------
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
--------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
-
D
I
L
K
K
V
E
--
K
G
KY
T
F
E
---
L
--
P
----
Q
----
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
186
Blastp_CBE
44.22
36%
18
- C2 -
-
3UPZ
4.4
-
?
A:
[21-290]
------------T-------
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
--------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
-
D
I
L
K
K
V
E
--
K
G
KY
T
F
E
---
L
--
P
----
Q
----
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
170
Blastp_CBE
44.21
36%
18
- C2 -
-
5W9R
6.4
-
?
A:
[21-303]
------------T-------
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
--------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
-
D
I
L
K
K
V
E
--
K
G
KY
T
F
E
---
L
--
P
----
Q
----
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
293
Blastp_CBE
44.19
36%
21
- C2 -
-
3BQR
5.9
-
DAPK3_HUMAN
A:
[7-268]
--------------------------
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
--
I
K
K
R
R
-
L
-
S
-----
S
S
RRGV
S
-
R
---
E
E
I
E
---
R
E
V
N
I
L
R
E
I
R
-
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
---
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
K
---
N
VPNP
R
---
I
K
L
I
D
F
G
I
-
A
H
K
-
I
---
E
A
-
G
--
N
-----
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
--
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
--
E
T
K
Q
-
E
T
L
T
N
I
S
AV
N
Y
--
D
F
D
---
E
--
E
----
Y
----
F
--
S
N
-------
T
S
EL-----
A
K
D
F
----
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
T
I
A
Q
S
L
E
H
S
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
181
Blastp_CBE
44.11
36%
14
- C2 -
-
4M84
4.2
-
?
A:
[21-284]
------------T-------
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
--------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
-
D
I
L
K
K
V
E
--
K
G
KY
T
F
E
---
L
--
P
----
Q
----
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
189
Blastp_CBE
44.01
36%
19
- C2 -
-
3T3U
6.1
-
?
A:
[22-295]
--------------------
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
--------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
-
D
I
L
K
K
V
E
--
K
G
KY
T
F
E
---
L
--
P
----
Q
----
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
176
Blastp_CBE
44.00
36%
17
- C2 -
-
4WG5
6.2
-
?
A:
[21-284]
------------T-------
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
--------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
-
D
I
L
K
K
V
E
--
K
G
KY
T
F
E
---
L
--
P
----
Q
----
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
192
Blastp_CBE
43.97
36%
22
- C2 -
-
3N51
5.5
-
?
A:
[22-299]
--------------------
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
--------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
-
D
I
L
K
K
V
E
--
K
G
KY
T
F
E
---
L
--
P
----
Q
----
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
161
Blastp_CBE
43.90
36%
15
- C2 -
-
5T6A
5.8
-
?
A:
[63-356]
--------------------
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
----
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
--------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
-
D
I
L
K
K
V
E
--
K
G
KY
T
F
E
---
L
--
P
----
Q
----
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
291
Blastp_CBE
43.79
36%
30
- C2 -
-
5A6N
2.9
-
DAPK3_HUMAN
B:
[7-268]
--------------------------
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
--
I
K
K
R
R
-
L
-
S
-----
S
S
RRGV
S
-
R
---
E
E
I
E
---
R
E
V
N
I
L
R
E
I
R
-
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
---
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
K
---
N
VPNP
R
---
I
K
L
I
D
F
G
I
-
A
H
K
-
I
---
E
----------
K
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
--
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
--
E
T
K
Q
-
E
T
L
T
N
I
S
AV
N
Y
--
D
F
D
---
E
--
E
----
Y
----
F
--
S
N
-------
T
S
EL-----
A
K
D
F
----
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
T
I
A
Q
S
L
E
H
S
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
221
Blastp_CBE
43.61
36%
10
- C2 -
-
4YUQ
5.8
-
?
B:
[21-291]
---------
V
Q
H
ST------
A
A
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
V
T
G
Q
E
Y
A
V
K
V
--
I
S
K
R
Q
-----------------------
L
L
---
K
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
N
K
---
R
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
S
--
T
-
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
--------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
F
-
D
I
L
K
K
V
E
--
K
G
KF
T
F
D
---
L
--
P
----
Q
----
W
KK
V
S
-------
E
P
-------
A
K
D
L
----
I
R
K
M
L
A
Y
V
P
T
M
R
I
-----
S
A
R
D
A
L
E
H
E
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
187
Blastp_CBE
43.59
36%
21
- C2 -
-
3UPX
6.6
-
?
A:
[21-303]
------------T-------
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
--------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
-
D
I
L
K
K
V
E
--
K
G
KY
T
F
E
---
L
--
P
----
Q
----
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
290
Blastp_CBE
43.55
36%
31
- C2 -
-
5A6O
2.9
-
DAPK3_HUMAN
A:
[7-268]
--------------------------
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
--
I
K
K
R
R
-
L
-
S
-----
S
S
RRGV
S
-
R
---
E
E
I
E
---
R
E
V
N
I
L
R
E
I
R
-
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
---
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
K
---
N
VPNP
R
---
I
K
L
I
D
F
G
I
-
A
H
K
-
I
---
E
----------
K
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
--
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
--
E
T
K
Q
-
E
T
L
T
N
I
S
AV
N
Y
--
D
F
D
---
E
--
E
----
Y
----
F
--
S
N
-------
T
S
EL-----
A
K
D
F
----
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
T
I
A
Q
S
L
E
H
S
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
225
Blastp_CBE
43.51
36%
9
- C2 -
-
4YSJ
6.6
-
?
B:
[21-290]
---------
V
Q
H
ST------
A
A
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
V
T
G
Q
E
Y
A
V
K
V
--
I
S
K
R
------------------------
L
L
---
K
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
N
K
---
R
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
S
--
T
-
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
--------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
F
-
D
I
L
K
K
V
E
--
K
G
KF
T
F
D
---
L
--
P
----
Q
----
W
KK
V
S
-------
E
P
-------
A
K
D
L
----
I
R
K
M
L
A
Y
V
P
T
M
R
I
-----
S
A
R
D
A
L
E
H
E
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
163
Blastp_CBE
43.45
36%
22
- C2 -
-
5JMS
6.0
-
?
A:
[62-342]
------------T-------
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
--
S
-
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
--------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
-
D
I
L
K
K
V
E
--
K
G
KY
T
F
E
---
L
--
P
----
Q
----
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
159
Blastp_CBE
43.35
36%
17
- C2 -
-
5T6K
3.8
-
?
A:
[62-356]
------------T-------
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
Q
-
V
-
K
QKTDK
E
S
----
L
-
L
----------
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
---
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
K
---
S
KDA-
N
---
I
R
I
I
D
F
G
L
-
S
-
T
-
H
---
F
E
-
A
----
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
Y
D
--------
E
K
-----
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
N
E
Y
-
D
I
L
K
K
V
E
--
K
G
KY
T
F
E
---
L
--
P
----
Q
----
W
KK
V
S
-------
E
S
-------
A
K
D
L
----
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
549
Blastp_CBE
43.27
36%
19
- C2 -
-
6AAR
4.8
-
DAPK1_HUMAN
A:
[13-274]
--------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
R
-
T
-
K
-----
S
S
RRGV
S
-
R
---
E
D
I
E
---
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-------
L
T
E
---
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
-
A
H
K
-
I
---
D
F
-
G
--
N
-
E
-
F
K
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
--
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
--
D
T
K
Q
-
E
T
L
A
N
V
S
--
A
V
--
N
Y
E
---
F
--
E
----
D
----
E
--
Y
F
-------
S
N
-------
T
S
A
L
AKDF
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
470
Blastp_CBE
43.26
34%
-15
- C2 -
-
2JDS
Error
-
KAPCA_BOVIN
A:
[35-298]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
----
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
292
Blastp_CBE
43.20
36%
31
- C2 -
-
5A6N
3.8
-
DAPK3_HUMAN
A:
[7-268]
--------------------------
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
--
I
K
K
R
R
-
L
-
S
-----
S
S
RRGV
S
-
R
---
E
E
I
E
---
R
E
V
N
I
L
R
E
I
R
-
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
---
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
K
---
N
VPNP
R
---
I
K
L
I
D
F
G
I
-
A
H
K
-
I
---
E
A
-
G
--
N
-
E
-
F
K
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
--
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
--
E
T
K
Q
-
E
T
L
T
N
I
S
AV
N
Y
--
D
F
D
---
E
--
E
----
Y
----
F
--
S
N
-------
T
S
EL-----
A
K
D
F
----
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
T
I
A
Q
S
L
E
H
S
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
464
Blastp_CBE
43.18
34%
-14
- C2 -
-
1XH7
4.2
-
KAPCA_BOVIN
A:
[34-297]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
----
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
511
Blastp_CBE
43.16
33%
-21
- C2 -
-
4C35
4.1
-
KAPCA_BOVIN
A:
[35-298]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
Y
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
----
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
512
Blastp_CBE
43.15
33%
-18
- C2 -
-
4C34
2.2
-
KAPCA_BOVIN
A:
[35-299]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
Y
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
----
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
465
Blastp_CBE
42.90
34%
-16
- C2 -
-
3ZO2
5.4
-
KAPCA_BOVIN
A:
[35-298]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
----
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
501
Blastp_CBE
42.89
34%
-14
- C2 -
-
4WB6
4.5
-
KAPCA_HUMAN
A:
[34-297]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
----
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
T
---
C
G
T
P
E
Y
R
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
502
Blastp_CBE
42.85
33%
-17
- C2 -
-
4C38
1.4
-
KAPCA_BOVIN
A:
[35-298]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
Y
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
----
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
515
Blastp_CBE
42.78
36%
12
- C2 -
-
3ZXT
5.4
-
DAPK1_HUMAN
B:
[13-274]
--------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
R
-
T
-
K
------
S
RRGV
S
-
R
---
E
D
I
E
---
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
L
T
E
---
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
-
A
H
K
-
I
---
D
----------------
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
--
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
-
L
S
G
A
S
P
F
L
G
--
D
T
K
Q
-
E
T
L
A
N
V
S
--
A
V
--
N
Y
E
---
F
--
E
----
D
----
E
--
Y
F
-----------------
S
A
L
AKDF
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
468
Blastp_CBE
42.73
34%
-16
- C2 -
-
3ZO3
5.4
-
KAPCA_BOVIN
A:
[35-298]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
----
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
510
Blastp_CBE
42.71
33%
-16
- C2 -
-
4C36
1.9
-
KAPCA_BOVIN
A:
[35-298]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
Y
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
----
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
467
Blastp_CBE
42.59
34%
-17
* C2 *
-
5VHB
1.3
-
KAPCA_BOVIN
A:
[35-303]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
----
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
503
Blastp_CBE
42.54
33%
-13
- C2 -
-
4C37
1.5
-
KAPCA_BOVIN
A:
[35-298]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
Y
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
----
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
246
Blastp_CBE
42.36
37%
0
- C2 -
-
2WTJ
4.7
-
CHK2_HUMAN
A:
[18-283]
--------------------------
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
--------------------PA-
L
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
--
E
--
T
-
S
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
--
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
--
S
G
--
K
Y
------------
N
----
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
243
Blastp_CBE
42.19
37%
9
- C2 -
-
2XM9
7.5
-
CHK2_HUMAN
A:
[18-283]
--------------------------
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
--------------------PA-
L
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
G
-
E
--
T
-
S
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
--
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
--
S
G
--
K
Y
------------
N
----
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
469
Blastp_CBE
42.15
34%
-13
- C2 -
-
3ZO1
5.0
-
KAPCA_BOVIN
A:
[35-298]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
----
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
461
Blastp_CBE
42.04
34%
-11
- C2 -
-
3BWJ
3.0
-
KAPCA_BOVIN
A:
[34-297]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
----
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
463
Blastp_CBE
41.80
34%
-16
- C2 -
-
1Q8W
3.0
-
KAPCA_BOVIN
A:
[34-297]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
----
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
490
Blastp_CBE
41.79
34%
-17
- C2 -
-
4WB5
5.3
-
KAPCA_HUMAN
A:
[34-297]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
----
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
462
Blastp_CBE
41.74
34%
-11
- C2 -
-
1XH4
0.0
-
KAPCA_BOVIN
A:
[34-297]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
----
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
242
Blastp_CBE
41.62
37%
7
- C2 -
-
4A9R
4.9
-
CHK2_HUMAN
A:
[18-283]
--------------------------
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
--------------------PA-
L
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
G
-
E
--
T
-
S
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
--
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
--
S
G
--
K
Y
------------
N
----
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
239
Blastp_CBE
41.55
37%
2
- C2 -
-
4A9U
6.3
-
CHK2_HUMAN
A:
[18-283]
--------------------------
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
--------------------DPA
L
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
-----
T
-
S
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
--
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
--
S
G
--
K
Y
------------
N
----
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
514
Blastp_CBE
41.49
36%
14
- C2 -
-
3ZXT
4.4
-
DAPK1_HUMAN
C:
[13-274]
--------------------------
Y
D
T
G
E
E
L
--
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
R
-
T
-
K
-----
S
S
RRGV
S
-
R
---
E
D
I
E
---
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
---
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
-
A
H
K
-
I
---
D
-----------------
P
E
F
V
A
P
E
I
V
--
N
Y
E
P
L
------
G
--
L
E
-----
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
--
D
T
K
Q
-
E
T
L
A
N
V
S
--
A
V
--
N
Y
E
---
F
--
E
----
D
----
E
--
Y
F
-------
S
N
-------
T
S
A
L
AKDF
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
460
Blastp_CBE
41.49
34%
-13
- C2 -
-
3KKV
Error
-
KAPCA_BOVIN
A:
[34-297]
---------
A
Q
N
--------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
--
L
D
K
Q
K
-
V
-
V
-----
K
-------
L
---
K
Q
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
E
P
----
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
-
A
-
K
-
R
---
V
K
-
G
--
R
-
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
G
Y
N
--------
K
A
-----
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
--
D
Q
P
I
-
Q
I
Y
E
K
I
V
--
S
G
--
K
V
R
---
F
--
P
----
S
----
H
--
F
S
-------
S
D
-------
L
K
D
L
----
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
240
Blastp_CBE
41.48
37%
13
- C2 -
-
4A9T
6.3
-
CHK2_HUMAN
A:
[18-283]
--------------------------
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
--------------------PA-
L
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
G
-
E
--
T
-
S
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
--
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
--
S
G
--
K
Y
------------
N
----
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
248
Blastp_CBE
41.40
37%
5
- C2 -
-
2WTD
6.8
-
CHK2_HUMAN
A:
[18-283]
--------------------------
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
--------------------PA-
L
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
-----
T
-
S
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
--
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
--
S
G
--
K
Y
------------
N
----
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
247
Blastp_CBE
41.38
37%
6
- C2 -
-
2WTI
6.8
-
CHK2_HUMAN
A:
[18-283]
--------------------------
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
--------------------PA-
L
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
--
E
--
T
-
S
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
--
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
--
S
G
--
K
Y
------------
N
----
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
241
Blastp_CBE
40.87
37%
4
- C2 -
-
4A9S
5.5
-
CHK2_HUMAN
A:
[18-283]
--------------------------
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
--------------------PA-
L
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
-----
T
-
S
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
--
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
--
S
G
--
K
Y
------------
N
----
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
249
Blastp_CBE
39.91
37%
10
- C2 -
-
2WTC
6.1
-
CHK2_HUMAN
A:
[18-283]
--------------------------
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
--------------------PA-
L
N
V
E
---
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
---
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
---
C
----
L
---
I
K
I
T
D
F
G
H
-
S
-
K
-
I
---
L
-----
T
-
S
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
A
G
Y
-----
N
--
R
A
-----
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
--
S
G
--
K
Y
------------
N
----
F
--
I
P
EVWAEVS
E
K
-------
A
L
D
L
----
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
139
Blastp_CBE
37.82
36%
11
- C2 -
-
2V7O
Error
-
KCC2G_HUMAN
A:
[15-290]
---------
T
E
N
LYFQMATC
T
R
F
T
D
D
Y
Q
L
F
E
E
L
G
K
G
A
-
S
V
V
R
R
C
V
K
K
T
P
T
Q
E
Y
A
A
K
I
--
I
N
T
K
K
-
L
-
S
-----
A
R
----
D
-
H
---
Q
K
L
E
---
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
---
A
D
A
S
H
C
I
H
Q
I
L
E
S
V
N
H
I
H
Q
H
D
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
K
---
C
----
K
GAA
V
K
L
A
D
F
G
L
-
A
I
E
-
V
---
Q
G
-
E
--
Q
-
Q
A
W
F
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
--
R
K
D
P
Y
------
G
--
K
P
-----
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
--
E
D
Q
H
-
K
L
Y
Q
Q
I
K
--
A
G
--
A
Y
D
---
F
--
P
SPEW
D
----
T
--
V
T
-------
P
E
-------
A
K
N
L
----
I
N
Q
M
L
T
I
N
P
A
K
R
I
-----
T
A
D
Q
A
L
K
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------