@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Screening
Virtual Screening Score
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : BTK_HUMAN: (2020-09-05 )
MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
Atome Classification :
(502 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240...-..-..250....-...260.......270.......280.......290-...-.-.-.-.-300.......-310........--320.......330........340.......350.......360.......370...--....380.......-------390-------------.---------------.-.......400-----...--------......410..-----.....420.---.---.-.-...430....--.---.---.440-.........450.......460.....-..-470.......480.....-..-490-.-..-.....500.......510.......520.......530.......540.......550--..-.-.-...560.......570.......580.......590.......600-.......610.......620.......630.......640.......650.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(pKd)
(pKd)
(Uniprot)
M
A
A
V
I
L
E
S
I
F
L
K
R
S
QQKKKTSPL
N
F
K
K
R
L
F
L
L
T
V
H
K
L
S
Y
Y
E
Y
D
F
E
RGRRGSKKGS
I
D
V
E
K
I
T
C
V
E
TVVPEKNPPPERQIPRRGE
E
S
S
E
M
E
Q
I
S
I
I
E
RFPY
P
F
Q
V
V
YDEG
P
L
Y
V
FS
P
T
E
E
L
R
K
R
W
I
H
Q
L
K
N
V
I
RY
N
S
D
L
V
Q
KYHP
C
F
W
IDG
Q
Y
L
C
C
S
Q
TAKNAMG
C
Q
I
LENRNGSLKPGSSHRKTKKPLPPTPE
E
D
Q
I
LKKPLPPEPAAAPV
S
T
S
E
L
K
K
V
V
A
L
Y
DYMPMNAND
L
Q
LRKGD
E
Y
F
I
L
E-ES-NLP
W
W
RARD-KNGQEGYIPSNYVTEAED
S
I
E
M
Y
E
W
Y
S
K
HM
T
R
S
Q
A
E
-
Q
L
L
-
K
-Q-E-G-KEG
G
F
I
V
RDS-SK-A
G
K
Y
T
V
S
V
--
F
AKSTG
D
P
Q
G
V
-
I
R
H
Y
V
V
CSTPQS
Q
Y
Y
L
A
E
K
H
L
F
S
T
I
P
E
L
I
N
Y
HQHN
S
A
G
L
I
S
R
LKY--PVSQQNKNAPSTAG-------L---------------G---------------Y-GSWEI
D
P
K
-------
D
L
T
--------
F
L
K
E
LGTGQ
F
G
-----
V
V
K
YGKWRG---
Q
---
Y
-
D
-
V
A
I
K
M
IKEGS--M---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
NL
S
H
E
K
L
V
Q
L
Y
G
V
CTKQ-R
P
-
I
F
I
I
T
E
Y
MAN
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
ARNCLVNDQ
G
V
V
K
V
SDFG
L
S
R
Y
V
LDDEY
T
--
S
S-V-G-SKFPVRWSPP
E
V
L
M
Y
SKFSSKS
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
LGKM
P
Y
E
RFT-N
S
E
T
A
E
H
I
A
Q
G
L
R
L
YRPHLAS
E
K
V
Y
T
I
M
Y
S
C
W
HEKADER
P
T
F
K
I
L
L
S
N
I
L
D
VMDEES
550
HHSearch
92.54
95%
-132
- C3 -
-
4Y93
9.4
-
?
A:
[2-446]
M
A
T
V
I
L
E
S
I
F
L
K
R
S
--------
L
N
F
K
K
R
L
F
L
L
T
V
Q
K
L
S
Y
Y
E
Y
D
F
E
R
G
R
R
G
S
K
K
G
S
I
D
V
E
K
I
T
C
V
E
T
V
V
P
E
K
N
P
P
P
E
R
Q
I
P
---------
E
Q
I
S
I
I
E
R
F
P
Y
P
F
Q
V
V
Y
D
E
G
P
L
Y
V
F
S
P
T
E
E
L
R
K
R
W
I
H
Q
L
K
N
V
I
R
Y
N
S
D
L
V
Q
K
Y
H
P
C
F
W
I
D
G
Q
Y
L
C
C
S
Q
T
A
K
N
A
M
G
C
Q
I
L
A
A
A
P
-----------------------------------
S
-----------------------------------------
T
-------------------------
A
-
G
L
---
G
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
D
E
Y
T
--
S
S
-
T
-
G
-
S
K
F
P
V
K
W
A
S
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
P
R
P
H
L
A
S
E
R
V
Y
A
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
1
PsiBlast_PDB
91.42
98%
-127
- C3 -
-
4XI2
-
-
BTK_MOUSE
A:
[1-444]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
L
K
K
V
V
A
L
Y
D
Y
M
P
M
N
A
N
D
L
Q
L
R
K
G
E
E
Y
F
I
L
E
-
E
S
-
N
L
P
W
W
R
A
R
D
-
K
N
G
Q
E
G
Y
I
P
S
N
Y
I
T
E
A
E
D
S
I
E
M
Y
E
W
Y
S
K
H
M
T
R
S
Q
A
E
-
Q
L
L
----------
E
G
G
F
I
V
R
D
--------
Y
T
V
S
V
--
F
A
K
------
G
V
-
I
R
H
Y
V
V
C
------
Y
Y
L
A
E
K
H
L
F
S
T
I
P
E
L
I
N
Y
H
Q
H
N
S
A
G
L
I
S
R
L
K
Y
--
P
V
S
K
Q
N
K
N
A
P
S
T
A
G
-------
L
---------------
G
---------------
Y
-
G
S
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
R
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
R
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
S
F
K
I
L
L
S
N
I
L
D
V
M
D
E
--
541
HHSearch
91.33
98%
-128
- C3 -
-
4XI2
-
-
BTK_MOUSE
A:
[3-444]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
K
V
V
A
L
Y
D
Y
M
P
M
N
A
N
D
L
Q
L
R
K
G
E
E
Y
F
I
L
E
-
E
S
-
N
L
P
W
W
R
A
R
D
-
K
N
G
Q
E
G
Y
I
P
S
N
Y
I
T
E
A
E
D
S
I
E
M
Y
E
W
Y
S
K
H
M
T
R
S
Q
A
E
-
Q
L
L
----------
E
G
G
F
I
V
R
D
--------
Y
T
V
S
V
--
F
A
K
------
G
V
-
I
R
H
Y
V
V
C
------
Y
Y
L
A
E
K
H
L
F
S
T
I
P
E
L
I
N
Y
H
Q
H
N
S
A
G
L
I
S
R
L
K
Y
--
P
V
S
K
Q
N
K
N
A
P
S
T
A
G
-------
L
---------------
G
---------------
Y
-
G
S
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
R
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
R
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
S
F
K
I
L
L
S
N
I
L
D
V
M
D
E
--
44
Blastp_CBE
72.51
100%
-147
- C3 -
-
6DI5
7.3
-
A:
[1-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------
L
---------------
G
---------------
Y
-
G
S
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
58
Blastp_CBE
71.69
97%
-143
- C3 -
-
4Y93
9.4
-
?
A:
[172-446]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
S
T
A
G
-------
L
---------------
G
---------------
Y
-
G
S
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
D
E
Y
T
--
S
S
-
T
-
G
-
S
K
F
P
V
K
W
A
S
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
P
R
P
H
L
A
S
E
R
V
Y
A
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
42
Blastp_CBE
71.65
100%
-141
- C3 -
-
6N9P
6.9
-
A:
[1-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------
L
---------------
G
---------------
Y
-
G
S
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
40
Blastp_CBE
71.60
100%
-139
- C3 -
-
6OMU
6.7
-
A:
[1-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------
L
---------------
G
---------------
Y
-
G
S
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
48
Blastp_CBE
71.47
100%
-138
- C3 -
-
5VFI
10.7
-
A:
[1-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------
L
---------------
G
---------------
Y
-
G
S
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
49
Blastp_CBE
71.43
100%
-132
- C3 -
-
5U9D
10.3
-
A:
[1-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------
L
---------------
G
---------------
Y
-
G
S
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
47
Blastp_CBE
71.39
100%
-137
- C3 -
-
6DI0
4.2
-
A:
[1-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------
L
---------------
G
---------------
Y
-
G
S
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
39
Blastp_CBE
71.38
99%
-141
- C3 -
-
3PIX
6.0
-
A:
[6-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
---------------
Y
-
G
S
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
41
Blastp_CBE
71.25
100%
-134
- C3 -
-
6NFH
7.2
-
A:
[1-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------
L
---------------
G
---------------
Y
-
G
S
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
25
Blastp_CBE
71.22
99%
-143
- C3 -
-
3GEN
8.7
-
A:
[16-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
G
S
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
---
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
54
Blastp_CBE
71.03
100%
-135
- C3 -
-
4ZLY
4.2
-
A:
[1-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------
L
---------------
G
---------------
Y
-
G
S
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
19
PsiBlast_PDB
71.03
99%
-134
- C3 -
-
5P9K
6.6
-
A:
[9-279]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------
L
---------------
G
---------------
Y
-
G
S
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
77
Blastp_CBE
70.94
99%
-145
- C3 -
-
5BPY
7.3
-
BTK_HUMAN
A:
[3-265]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
--
33
Blastp_CBE
70.93
98%
-134
- C3 -
-
6E4F
9.0
-
A:
[20-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------
L
---------------
G
---------------
Y
-
G
S
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
60
Blastp_CBE
70.90
100%
-144
- C3 -
-
6S90
10.3
-
BTK_HUMAN
A:
[3-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
---
23
Blastp_CBE
70.80
99%
-138
- C3 -
-
5P9M
7.5
-
A:
[9-279]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------
L
---------------
G
---------------
Y
-
G
S
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
17
PsiBlast_PDB
70.75
99%
-136
- C3 -
-
5P9I
9.1
-
A:
[9-279]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------
L
---------------
G
---------------
Y
-
G
S
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
46
Blastp_CBE
70.73
100%
-137
- C3 -
-
6DI1
3.8
-
A:
[1-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------
L
---------------
G
---------------
Y
-
G
S
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
57
Blastp_CBE
70.70
99%
-139
- C3 -
-
6J6M
8.3
-
?
A:
[3-269]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
30
Blastp_CBE
70.66
100%
-134
- C3 -
-
5J87
9.6
-
BTK_HUMAN
B:
[1-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
T
A
G
-------
L
---------------
G
---------------
Y
-
G
S
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
22
Blastp_CBE
70.41
100%
-131
- C3 -
-
4YHF
9.3
-
B:
[9-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------------
G
---------------
Y
-
G
S
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
10
PsiBlast_PDB
70.41
98%
-142
- C3 -
-
6EP9
9.9
-
A:
[20-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
A
-
R
-
H
-
A
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
53
Blastp_CBE
70.37
100%
-135
- C3 -
-
4ZLZ
5.4
-
A:
[1-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------
L
---------------
G
---------------
Y
-
G
S
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
26
Blastp_CBE
70.33
99%
-133
- C3 -
-
4Z3V
6.7
-
A:
[13-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------
L
---------------
G
---------------
Y
-
G
S
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
8
PsiBlast_PDB
70.24
98%
-140
- C3 -
-
4RFZ
10.0
-
A:
[20-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
A
-
R
-
H
-
A
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
4
PsiBlast_PDB
70.16
98%
-142
- C3 -
-
4OT6
7.0
-
A:
[18-282]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
A
-
R
-
H
-
A
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
9
PsiBlast_PDB
70.12
98%
-141
- C3 -
-
4RG0
10.4
-
A:
[20-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
A
-
R
-
H
-
A
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
55
Blastp_CBE
69.90
100%
-146
- C3 -
-
6O8I
5.4
-
A:
[1-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
---------------
Y
-
G
S
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
-------------------
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
15
PsiBlast_PDB
69.90
99%
-140
- C3 -
-
5P9G
10.3
-
A:
[14-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
61
Blastp_CBE
69.89
100%
-138
- C3 -
-
5VGO
10.1
-
A:
[3-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
--
59
Blastp_CBE
69.87
100%
-141
- C3 -
-
6S90
10.3
-
B:
[3-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
---
5
PsiBlast_PDB
69.85
98%
-140
- C3 -
-
4OTQ
9.6
-
A:
[20-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
A
-
R
-
H
-
A
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
2
PsiBlast_PDB
69.76
99%
-139
- C3 -
-
6NZM
10.1
-
BTK_HUMAN
A:
[16-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
----
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
12
PsiBlast_PDB
69.72
98%
-138
- C3 -
-
6HRT
11.4
-
A:
[20-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
A
-
R
-
H
-
A
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
11
PsiBlast_PDB
69.59
98%
-138
- C3 -
-
6HRP
10.3
-
A:
[20-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
A
-
R
-
H
-
A
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
80
Blastp_CBE
69.54
99%
-139
- C3 -
-
6AUA
9.4
-
A:
[1-263]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
A
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
---
16
PsiBlast_PDB
69.53
99%
-146
- C3 -
-
5P9H
8.6
-
A:
[15-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
63
Blastp_CBE
69.52
100%
-140
- C3 -
-
4RX5
8.5
-
A:
[3-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
--
62
Blastp_CBE
69.52
100%
-136
- C3 -
-
5KUP
10.2
-
A:
[3-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
--
21
Blastp_CBE
69.52
99%
-137
- C3 -
-
6NZM
10.5
-
D:
[16-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
6
PsiBlast_PDB
69.49
98%
-141
- C3 -
-
4OTR
10.4
-
A:
[20-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
A
-
R
-
H
-
A
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
64
Blastp_CBE
69.48
100%
-138
- C3 -
-
3OCS
9.7
-
A:
[4-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
--
14
PsiBlast_PDB
69.48
99%
-136
- C3 -
-
5P9F
10.2
-
A:
[14-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
78
Blastp_CBE
69.47
100%
-138
- C3 -
-
6AUB
9.8
-
A:
[1-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
--
7
PsiBlast_PDB
69.34
98%
-142
- C3 -
-
4RFY
9.7
-
A:
[20-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
A
-
R
-
H
-
A
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
13
PsiBlast_PDB
69.33
100%
-133
- C3 -
-
4YHF
8.8
-
BTK_HUMAN
A:
[10-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
---------------
Y
-
G
S
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
3
PsiBlast_PDB
69.29
98%
-140
- C3 -
-
4OT5
10.4
-
A:
[20-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
A
-
R
-
H
-
A
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
24
Blastp_CBE
69.27
99%
-144
- C3 -
-
5BQ0
7.3
-
A:
[13-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------
L
---------------
G
---------------
Y
-
G
S
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
-----------
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
73
Blastp_CBE
68.90
99%
-137
- C3 -
-
5T18
9.0
-
A:
[2-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--------
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
85
Blastp_CBE
68.83
99%
-135
- C3 -
-
6BIK
9.4
-
A:
[4-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
-
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
--
75
Blastp_CBE
68.73
99%
-143
- C3 -
-
5JRS
9.0
-
BTK_HUMAN
A:
[3-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--------
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
---
31
Blastp_CBE
68.67
100%
-136
- C3 -
-
5J87
9.4
-
BTK_HUMAN
A:
[12-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
82
Blastp_CBE
68.54
99%
-133
- C3 -
-
6BKW
8.9
-
A:
[2-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
-
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
--
28
Blastp_CBE
68.53
100%
-137
- C3 -
-
5J87
7.6
-
D:
[12-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
29
Blastp_CBE
68.52
100%
-135
- C3 -
-
5J87
9.2
-
BTK_HUMAN
C:
[12-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
---
81
Blastp_CBE
68.39
99%
-136
- C3 -
-
6BLN
8.6
-
A:
[4-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
-
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
--
84
Blastp_CBE
68.22
99%
-136
- C3 -
-
6BKE
9.3
-
A:
[4-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
-
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
--
38
Blastp_CBE
68.10
99%
-131
- C3 -
-
3PIY
7.8
-
A:
[6-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
---------------
Y
-
G
S
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
--------------
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
549
HHSearch
67.63
40%
2
- C3 -
-
2FO0
9.8
-
ABL1_HUMAN
A:
[38-476]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
D
P
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
G
-
Y
N
H
N
G
E
W
C
E
A
Q
--
T
K
N
G
Q
G
W
V
P
S
N
Y
I
T
P
V
-
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
-
Y
L
L
-
S
-
S
---
G
-
I
N
G
S
F
L
V
R
E
S
-
E
S
S
P
G
Q
R
S
I
S
L
--
R
Y
E
------
G
R
-
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
--
P
A
P
K
R
N
K
P
T
V
Y
G
V
S
-------
P
---------------
N
---------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
-
N
R
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
--
83
Blastp_CBE
67.63
99%
-134
- C3 -
-
6BKH
9.0
-
A:
[5-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
-
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
--
S
S
-
V
-
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
--
542
HHSearch
67.60
38%
12
- C3 -
-
2H8H
8.2
-
SRC_HUMAN
A:
[87-524]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
F
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
-
N
T
-
E
G
D
W
W
L
A
H
S
L
S
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
-
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
-
R
L
L
-
L
-
N
-
A
E
N
-
P
R
G
T
F
L
V
R
E
S
-
E
T
T
K
G
A
Y
C
L
S
V
--
S
D
F
D
N
-
A
K
G
L
N
-
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
--
V
C
P
T
S
---
K
P
Q
T
Q
G
-------
L
---------------
A
---------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
E
-
T
G
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
-
Q
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
--
51
Blastp_CBE
67.57
100%
-145
- C3 -
-
5FBN
11.3
-
D:
[6-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
---------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
544
HHSearch
67.48
39%
7
- C3 -
-
1Y57
7.3
-
SRC_HUMAN
A:
[3-441]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
F
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
-
N
T
-
E
G
D
W
W
L
A
H
S
L
S
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
-
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
-
R
L
L
-
L
-
N
A
E
-
N
-
P
R
G
T
F
L
V
R
E
S
-
E
T
T
K
G
A
Y
C
L
S
V
--
S
D
F
D
N
-
A
K
G
L
N
-
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
--
V
C
P
T
S
---
K
P
Q
T
Q
G
-------
L
---------------
A
---------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
-
G
E
-
T
G
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
-
Q
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
--
552
HHSearch
67.27
40%
-12
- C3 -
-
1OPK
10.3
-
ABL1_MOUSE
A:
[44-480]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
G
-
Y
N
-
H
N
G
E
W
C
E
A
Q
-
T
K
N
G
Q
G
W
V
P
S
N
Y
I
T
P
V
-
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
-
Y
L
L
-
S
-
S
---
G
-
I
N
G
S
F
L
V
R
E
S
-
E
S
S
P
G
Q
R
S
I
S
L
--
R
Y
E
------
G
R
-
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
--
P
A
P
K
R
N
K
P
T
I
Y
G
V
S
-------
P
---------------
N
---------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
-
N
R
Q
-
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
-
18
PsiBlast_PDB
67.10
99%
-142
- C3 -
-
5P9J
8.7
-
A:
[14-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
-------
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
35
Blastp_CBE
66.36
99%
-154
- C3 -
-
3PJ2
7.7
-
A:
[6-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
---------------
Y
-
G
S
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
---
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
-----------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
546
HHSearch
65.99
39%
8
- C3 -
-
5H0B
10.2
-
HCK_HUMAN
A:
[8-445]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
-
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
-
R
Q
L
-
L
-
A
-
P
G
N
-
M
L
G
S
F
M
I
R
D
S
-
E
T
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
-
R
Q
G
D
T
-
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
--
P
C
M
S
S
K
P
Q
----
K
P
-------
W
---------------
E
---------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
-----
E
V
W
M
A
T
Y
N
K
---
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
---
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
--
E
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
D
-
E
G
S
-
K
-
Q
P
-
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
Y
T
--
A
R
-
E
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
--
45
Blastp_CBE
65.98
100%
-146
- C3 -
-
6DI3
7.5
-
A:
[5-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
--
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
--------------
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
207
Blastp_CBE
65.89
39%
19
- C3 -
-
2H8H
8.1
-
SRC_HUMAN
A:
[87-520]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-----
F
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
-
N
T
-
E
G
D
W
W
L
A
H
S
L
S
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
-
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
-
R
L
L
L
N
-
A
-
E
-
N
-
P
R
G
T
F
L
V
R
E
S
E
T
T
-
K
G
A
Y
C
L
S
V
----
S
D
F
D
N
A
K
G
L
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
VC
P
T
S
K
-----
P
Q
T
Q
G
-------
L
---------------
A
---------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
-
Q
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
164
Blastp_CBE
65.43
42%
7
- C3 -
-
1OPK
10.3
-
ABL1_MOUSE
A:
[47-466]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
G
Y
N
H
-
N
G
E
W
C
E
A
Q
T
-
K
N
G
Q
-
G
W
V
P
S
N
Y
I
T
P
V
-
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
-
Y
L
L
-
S
-
S
---
G
-
I
N
G
S
F
L
V
R
E
S
E
S
S
-
P
G
Q
R
S
I
S
L
--
R
Y
------
E
G
R
-
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
--
P
A
P
K
R
N
K
--
P
T
I
Y
G
-------
V
SP-------------
N
---------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
50
Blastp_CBE
65.40
100%
-155
- C3 -
-
5FBO
10.7
-
A:
[4-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
G
S
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-------------------
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
52
Blastp_CBE
65.21
100%
-146
- C3 -
-
5FBN
11.3
-
BTK_HUMAN
C:
[7-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
-------------
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
43
Blastp_CBE
65.09
100%
-152
- C3 -
-
6DI9
5.4
-
A:
[4-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
G
S
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
-----------
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
---------------
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
112
Blastp_CBE
65.08
58%
-139
- C3 -
-
4M14
9.0
-
A:
[4-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
V
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
R
E
G
A
--
M
---
S
---
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
Y
T
--
S
S
-
T
-
G
-
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
116
Blastp_CBE
64.90
58%
-138
- C3 -
-
4M0Y
7.9
-
A:
[5-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
R
E
G
A
--
M
---
S
---
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
Y
T
--
S
S
-
T
-
G
-
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
206
Blastp_CBE
64.86
39%
24
- C3 -
-
2SRC
5.4
-
SRC_HUMAN
A:
[6-437]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
-
N
T
-
E
G
D
W
W
L
A
H
S
L
S
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
-
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
-
R
L
L
L
N
-
A
-
E
-
N
-
P
R
G
T
F
L
V
R
E
S
E
T
T
-
K
G
A
Y
C
L
S
V
----
S
D
F
D
N
A
K
G
L
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
VC
P
T
S
K
-----
P
Q
T
Q
G
-------
L
---------------
A
---------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
-
Q
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
20
PsiBlast_PDB
64.83
99%
-152
- C3 -
-
5P9L
5.8
-
A:
[12-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
G
S
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
----
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
---------------
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
--
113
Blastp_CBE
64.80
58%
-141
- C3 -
-
4M13
9.9
-
A:
[4-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
V
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
R
E
G
A
--
M
---
S
---
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
Y
T
--
S
S
-
T
-
G
-
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
37
Blastp_CBE
64.76
99%
-148
- C3 -
-
3PIZ
7.0
-
A:
[6-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
---------------
Y
-
G
S
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
---
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
----------
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
---------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
167
Blastp_CBE
64.74
42%
9
- C3 -
-
1OPL
10.1
-
ABL1_HUMAN
A:
[86-505]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
G
Y
N
H
-
N
G
E
W
C
E
A
Q
T
-
K
N
G
Q
-
G
W
V
P
S
N
Y
I
T
P
V
-
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
-
Y
L
L
-
S
-
S
---
G
-
I
N
G
S
F
L
V
R
E
S
E
S
S
-
P
G
Q
R
S
I
S
L
--
R
Y
------
E
G
R
-
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
--
P
A
P
K
R
N
K
--
P
T
V
Y
G
-------
V
SP-------------
N
---------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
117
Blastp_CBE
64.71
58%
-144
- C3 -
-
4HCV
8.3
-
A:
[5-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
R
E
G
A
--
M
---
S
---
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
Y
T
--
S
S
-
T
-
G
-
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
79
Blastp_CBE
64.71
99%
-156
- C3 -
-
3OCT
8.9
-
A:
[3-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
--
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
-----
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
-------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
---
32
Blastp_CBE
64.70
99%
-154
- C3 -
-
6MNY
7.4
-
?
A:
[12-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
R
E
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
---------------
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
A
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
R
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
S
F
K
I
L
L
S
N
I
L
D
V
M
D
---
165
Blastp_CBE
64.63
42%
7
- C3 -
-
2FO0
9.8
-
ABL1_HUMAN
A:
[44-463]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
G
Y
N
H
-
N
G
E
W
C
E
A
Q
T
-
K
N
G
Q
-
G
W
V
P
S
N
Y
I
T
P
V
-
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
-
Y
L
L
-
S
-
S
---
G
-
I
N
G
S
F
L
V
R
E
S
E
S
S
-
P
G
Q
R
S
I
S
L
--
R
Y
------
E
G
R
-
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
--
P
A
P
K
R
N
K
--
P
T
V
Y
G
-------
V
SP-------------
N
---------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
111
Blastp_CBE
64.63
58%
-139
- C3 -
-
4M15
4.9
-
A:
[4-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
V
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
R
E
G
A
--
M
---
S
---
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
Y
T
--
S
S
-
T
-
G
-
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
118
Blastp_CBE
64.56
58%
-142
- C3 -
-
4HCU
8.5
-
A:
[5-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
R
E
G
A
--
M
---
S
---
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
Y
T
--
S
S
-
T
-
G
-
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
115
Blastp_CBE
64.55
58%
-139
- C3 -
-
4M0Z
5.2
-
A:
[4-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
V
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
R
E
G
A
--
M
---
S
---
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
Y
T
--
S
S
-
T
-
G
-
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
209
Blastp_CBE
64.48
39%
26
- C3 -
-
4K11
5.9
-
SRC_HUMAN
A:
[4-435]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
-
N
T
-
E
G
D
W
W
L
A
H
S
L
S
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
-
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
-
R
L
L
L
N
-
A
-
E
-
N
-
P
R
G
T
F
L
V
R
E
S
E
T
T
-
K
G
A
Y
C
L
S
V
----
S
D
F
D
N
A
K
G
L
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
VC
P
T
S
K
-----
P
Q
T
Q
G
-------
L
---------------
A
---------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
-
Q
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
205
Blastp_CBE
64.37
39%
22
- C3 -
-
1Y57
7.3
-
SRC_HUMAN
A:
[6-437]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
-
N
T
-
E
G
D
W
W
L
A
H
S
L
S
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
-
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
-
R
L
L
L
N
-
A
-
E
-
N
-
P
R
G
T
F
L
V
R
E
S
E
T
T
-
K
G
A
Y
C
L
S
V
----
S
D
F
D
N
A
K
G
L
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
VC
P
T
S
K
-----
P
Q
T
Q
G
-------
L
---------------
A
---------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
-
Q
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
114
Blastp_CBE
64.37
58%
-136
- C3 -
-
4M12
9.3
-
A:
[4-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
V
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
R
E
G
A
--
M
---
S
---
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
Y
T
--
S
S
-
T
-
G
-
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
34
Blastp_CBE
64.29
99%
-151
- C3 -
-
3PJ3
10.8
-
A:
[6-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
---------------
Y
-
G
S
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
---
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
---------------
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
------------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
119
Blastp_CBE
64.21
58%
-140
- C3 -
-
4HCT
9.6
-
A:
[3-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
W
V
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
R
E
G
A
--
M
---
S
---
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
Y
T
--
S
S
-
T
-
G
-
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
36
Blastp_CBE
64.20
99%
-156
- C3 -
-
3PJ1
7.6
-
A:
[6-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
---------------
Y
-
G
S
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
---
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
----------
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
----
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-----
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
---------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
110
Blastp_CBE
64.16
58%
-141
- C3 -
-
3T9T
6.1
-
A:
[3-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
R
E
G
A
--
M
---
S
---
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
T
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
Y
T
--
S
S
-
T
-
G
-
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
210
Blastp_CBE
64.02
39%
25
- C3 -
-
1KSW
5.9
-
SRC_HUMAN
A:
[6-437]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
-
N
T
-
E
G
D
W
W
L
A
H
S
L
S
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
-
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
-
R
L
L
L
N
-
A
-
E
-
N
-
P
R
G
T
F
L
V
R
E
S
E
T
T
-
K
G
A
Y
C
L
S
V
----
S
D
F
D
N
A
K
G
L
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
VC
P
T
S
K
-----
P
Q
T
Q
G
-------
L
---------------
A
---------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
-
Q
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
76
Blastp_CBE
64.02
99%
-158
- C3 -
-
5BPY
7.6
-
B:
[3-265]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
-
G
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
------
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
----------------
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
--
208
Blastp_CBE
63.97
39%
26
- C3 -
-
6F3F
5.4
-
SRC_MOUSE
A:
[9-440]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
-
N
T
-
E
G
D
W
W
L
A
H
S
L
S
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
-
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
-
R
L
L
L
N
-
A
-
E
-
N
-
P
R
G
T
F
L
V
R
E
S
E
T
T
-
K
G
A
Y
C
L
S
V
----
S
D
F
D
N
A
K
G
L
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
VC
P
T
S
K
-----
P
Q
T
Q
G
-------
L
---------------
A
---------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
G
E
T
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
-
Q
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
93
Blastp_CBE
63.88
68%
-132
- C3 -
-
3SXS
7.3
-
A:
[1-259]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
M
E
L
K
R
E
-------
E
I
T
--------
L
L
K
E
L
G
S
G
Q
F
G
-----
V
V
K
L
G
K
W
K
G
---
Q
---
Y
-
D
-
V
A
V
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
F
Q
E
A
Q
T
M
M
K
L
S
H
P
K
L
V
K
F
Y
G
V
C
S
K
E
-
Y
P
-
I
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
-
S
H
-
G
-
K
-
G
-
L
E
-
P
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
D
R
D
L
C
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
D
Q
Y
V
--
S
S
-
V
-
G
-
T
K
F
P
V
K
W
S
A
P
E
V
F
H
Y
F
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
T
-
N
S
E
V
V
L
K
V
S
Q
G
H
R
L
Y
R
P
H
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
--------
72
Blastp_CBE
63.73
100%
-163
- C3 -
-
5XYZ
6.9
-
BTK_HUMAN
A:
[3-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
------------
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
-----
M
---
S
---
E
D
------
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
------
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
-------------------
F
P
V
R
W
S
P
P
E
V
L
M
---
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
---
56
Blastp_CBE
63.65
100%
-154
- C3 -
-
6NFI
7.2
-
A:
[1-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
G
S
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
---------
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
---
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
----
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
---------------------
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
204
Blastp_CBE
63.56
39%
20
- C3 -
-
1QCF
6.4
-
HCK_HUMAN
A:
[11-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
-
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
-
M
L
G
S
F
M
I
R
D
S
E
T
T
-
K
G
S
Y
S
L
S
V
RD
Y
D
P
R
Q
G
D
---
T
-
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
--
P
C
M
S
S
K
P
Q
K
P
W
E
K
D
------------------------------------------
A
W
E
I
P
R
E
-------
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
-----
E
V
W
M
A
T
Y
N
K
---
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
---
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
D
-
E
-
G
-
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
Y
T
--
A
R
-
E
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
------
172
Blastp_CBE
63.35
39%
20
- C3 -
-
5H0B
10.2
-
HCK_HUMAN
A:
[11-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
-
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
-
M
L
G
S
F
M
I
R
D
S
E
T
T
-
K
G
S
Y
S
L
S
V
RD
Y
D
P
R
Q
G
D
---
T
-
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
--
P
C
M
S
S
K
P
Q
K
P
W
E
K
D
------------------------------------------
A
W
E
I
P
R
E
-------
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
-----
E
V
W
M
A
T
Y
N
K
---
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
---
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
D
-
E
-
G
-
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
Y
T
--
A
R
-
E
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
------
27
Blastp_CBE
63.22
99%
-150
- C3 -
-
3K54
7.4
-
A:
[16-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
G
S
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
------------------
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
----------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
547
HHSearch
62.99
39%
-20
- C3 -
-
5MO4
12.2
-
ABL1_HUMAN
A:
[44-480]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
G
-
Y
N
-
H
N
G
E
W
C
E
A
Q
-
T
K
N
G
Q
G
W
V
P
S
N
Y
I
T
P
V
-
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
-
Y
L
L
-
S
-
S
---
G
-
I
N
G
S
F
L
V
R
E
S
-
E
S
S
P
G
Q
R
S
I
S
L
--
R
Y
E
------
G
R
-
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
--
P
A
P
K
R
N
K
P
T
V
Y
G
V
S
-------
P
---------------
N
---------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
-------
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
-
N
R
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
-----------------------
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
-
169
Blastp_CBE
62.81
39%
20
- C3 -
-
5H0H
10.2
-
HCK_HUMAN
A:
[11-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
-
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
-
M
L
G
S
F
M
I
R
D
S
E
T
T
-
K
G
S
Y
S
L
S
V
RD
Y
D
P
R
Q
G
D
---
T
-
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
--
P
C
M
S
S
K
P
Q
K
P
W
E
K
D
------------------------------------------
A
W
E
I
P
R
E
-------
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
-----
E
V
W
M
A
T
Y
N
K
---
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
---
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
D
-
E
-
G
-
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
Y
T
--
A
R
-
E
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
------
71
Blastp_CBE
62.77
100%
-154
- C3 -
-
5XYZ
7.1
-
B:
[3-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
------------
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
-----
M
---
S
---
E
D
---
E
-
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-
R
-
H
-
R
-
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
-------------------
F
P
V
R
W
S
P
P
E
V
L
M
----
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
---
94
Blastp_CBE
62.76
68%
-131
- C3 -
-
3SXR
8.0
-
B:
[1-259]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
M
E
L
K
R
E
-------
E
I
T
--------
L
L
K
E
L
-----------
V
V
K
L
G
K
W
K
G
---
Q
---
Y
-
D
-
V
A
V
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
F
Q
E
A
Q
T
M
M
K
L
S
H
P
K
L
V
K
F
Y
G
V
C
S
K
E
-
Y
P
-
I
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
-
S
H
-
G
-
K
-
G
-
L
E
-
P
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
D
R
D
L
C
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
D
Q
Y
V
--
S
S
-
V
-
G
-
T
K
F
P
V
K
W
S
A
P
E
V
F
H
Y
F
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
T
-
N
S
E
V
V
L
K
V
S
Q
G
H
R
L
Y
R
P
H
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
--------
173
Blastp_CBE
62.69
39%
21
- C3 -
-
5H09
10.2
-
HCK_HUMAN
A:
[11-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
-
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
-
M
L
G
S
F
M
I
R
D
S
E
T
T
-
K
G
S
Y
S
L
S
V
RD
Y
D
P
R
Q
G
D
---
T
-
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
--
P
C
M
S
S
K
P
Q
K
P
W
E
K
D
------------------------------------------
A
W
E
I
P
R
E
-------
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
-----
E
V
W
M
A
T
Y
N
K
---
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
---
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
D
-
E
-
G
-
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
Y
T
--
A
R
-
E
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
------
170
Blastp_CBE
62.65
39%
21
- C3 -
-
5H0G
9.5
-
HCK_HUMAN
A:
[11-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
-
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
-
M
L
G
S
F
M
I
R
D
S
E
T
T
-
K
G
S
Y
S
L
S
V
RD
Y
D
P
R
Q
G
D
---
T
-
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
--
P
C
M
S
S
K
P
Q
K
P
W
E
K
D
------------------------------------------
A
W
E
I
P
R
E
-------
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
-----
E
V
W
M
A
T
Y
N
K
---
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
---
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
D
-
E
-
G
-
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
Y
T
--
A
R
-
E
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
------
128
Blastp_CBE
62.53
59%
-136
- C3 -
-
3MJ2
6.5
-
A:
[4-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
R
E
G
A
--
M
---
S
---
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
Y
T
--
S
S
-
T
-
G
-
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
-----
95
Blastp_CBE
62.46
68%
-127
- C3 -
-
3SXR
8.1
-
BMX_HUMAN
A:
[1-259]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
M
E
L
K
R
E
-------
E
I
T
--------
L
L
K
E
L
G
S
---------
V
V
K
L
G
K
W
K
G
---
Q
---
Y
-
D
-
V
A
V
K
M
I
K
E
G
S
--
M
---
S
---
E
D
---
E
F
F
Q
E
A
Q
T
M
M
K
L
S
H
P
K
L
V
K
F
Y
G
V
C
S
K
E
-
Y
P
-
I
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
-
S
H
-
G
-
K
-
G
-
L
E
-
P
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
D
R
D
L
C
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
D
Q
Y
V
--
S
S
-
V
-
G
-
T
K
F
P
V
K
W
S
A
P
E
V
F
H
Y
F
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
T
-
N
S
E
V
V
L
K
V
S
Q
G
H
R
L
Y
R
P
H
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
--------
74
Blastp_CBE
62.32
99%
-154
- C3 -
-
5JRS
9.0
-
B:
[3-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
I
D
P
K
-------
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
-----
V
V
K
Y
G
K
W
R
G
---
Q
---
Y
-
D
-
V
A
I
K
M
I
K
--
S
--
M
---
S
---
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
------
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
--------
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
----------------
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
----
554
HHSearch
62.25
36%
-45
- C3 -
-
3BKB
8.5
-
A:
[7-375]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
-
E
L
L
-
V
-------
H
S
G
D
F
L
V
R
E
S
-
Q
G
-
K
Q
E
Y
V
L
S
V
--
L
W
D
------
G
L
-
P
R
H
F
I
I
Q
S
-
L
D
N
L
Y
R
L
-
E
G
E
G
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
P
L
T
K
K
S
G
V
--
V
L
H
R
---------
A
-------
V
---------------
P
---------------
K
-
D
K
W
V
L
N
H
E
-------
D
L
V
--------
L
G
E
Q
I
G
R
G
N
F
G
-----
E
V
F
S
G
R
L
R
A
D--
N
---
T
-
L
-
V
A
V
K
S
C
R
E
T
L
--
P
PD-
L
---
K
A
---
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
-
Q
P
-
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
-
T
E
-
G
-
A
-
R
-
L
R
-
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
--
A
S
-
G
G
L
-
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
-
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
--
553
HHSearch
62.20
36%
-49
- C3 -
-
6JMF
6.5
-
A:
[5-373]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
-
E
L
L
-
V
-------
H
S
G
D
F
L
V
R
E
S
-
Q
G
-
K
Q
E
Y
V
L
S
V
--
L
W
D
------
G
L
-
P
R
H
F
I
I
Q
S
-
L
D
N
L
Y
R
L
-
E
G
E
G
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
P
L
T
K
K
S
G
V
--
V
L
H
---------
R
A
-------
V
---------------
P
---------------
K
-
D
K
W
V
L
N
H
E
-------
D
L
V
--------
L
G
E
Q
I
G
R
G
N
F
G
-----
E
V
F
S
G
R
L
R
A
D--
N
---
T
-
L
-
V
A
V
K
S
C
R
E
T
L
PP
D
---
L
---
K
A
---
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
-
Q
P
-
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
-
T
E
-
G
-
A
-
R
-
L
R
-
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
--
A
S
G
G
-
L
-
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
-
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
--
171
Blastp_CBE
62.12
39%
20
- C3 -
-
5H0E
10.0
-
HCK_HUMAN
A:
[11-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
-
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
-
M
L
G
S
F
M
I
R
D
S
E
T
T
-
K
G
S
Y
S
L
S
V
RD
Y
D
P
R
Q
G
D
---
T
-
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
--
P
C
M
S
S
K
P
Q
K
P
W
E
K
D
------------------------------------------
A
W
E
I
P
R
E
-------
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
-----
E
V
W
M
A
T
Y
N
K
---
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
---
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
D
-
E
-
G
-
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
Y
T
--
A
R
-
E
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
------
168
Blastp_CBE
60.44
42%
6
- C3 -
-
5MO4
12.2
-
ABL1_HUMAN
A:
[47-466]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
G
Y
N
H
-
N
G
E
W
C
E
A
Q
T
-
K
N
G
Q
-
G
W
V
P
S
N
Y
I
T
P
V
-
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
-
Y
L
L
-
S
-
S
---
G
-
I
N
G
S
F
L
V
R
E
S
E
S
S
-
P
G
Q
R
S
I
S
L
--
R
Y
------
E
G
R
-
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
--
P
A
P
K
R
N
K
--
P
T
V
Y
G
-------
V
SP-------------
N
---------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
-------
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
-----------------------
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
545
HHSearch
60.33
39%
6
- C3 -
-
2HCK
5.7
-
HCK_HUMAN
B:
[3-429]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
--
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
-
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
-
R
Q
L
-
L
-
A
-
P
-
G
N
M
L
G
S
F
M
I
R
D
S
-
E
T
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
-
R
Q
G
D
T
-
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
--
P
C
M
S
S
K
P
Q
K
----
P
-------
W
---------------
E
---------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
-----
E
V
W
M
A
T
Y
N
K
---
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
---
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
--
E
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
D
-
E
G
S
-
K
-
Q
P
-
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
G
A
---------------
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
--
192
Blastp_CBE
60.13
39%
16
- C3 -
-
3VS0
8.1
-
HCK_HUMAN
B:
[11-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
-
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
-
M
L
G
S
F
M
I
R
D
S
E
T
T
-
K
G
S
Y
S
L
S
V
RD
Y
D
P
R
Q
G
D
---
T
-
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
--
P
C
M
S
S
K
P
Q
K
P
W
E
K
D
------------------------------------------
A
W
E
I
P
R
E
-------
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
-----
E
V
W
M
A
T
Y
N
K
---
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
---
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
D
-
E
-
G
-
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
------
433
Blastp_CBE
60.12
36%
-45
- C3 -
-
6JMF
6.5
-
A:
[13-363]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
Y
H
G
A
I
P
R
A
E
V
A
-
E
L
L
-
V
-
H
-
S
-
G
-
D
---
F
L
V
R
E
S
-
Q
G
-
K
Q
E
Y
V
L
S
V
--
L
W
------
D
G
L
-
P
R
H
F
I
I
Q
S
L
--
D
N
L
Y
R
L
E
G
E
G
F
P
S
I
P
L
L
I
D
H
-------
L
L
S
T
-
Q
Q
--
P
L
T
K
K
S
G
V
V
L
H
R
A
--------
V
---------------
P
---------------
K
-
D
K
W
V
L
N
H
E
-------
D
L
V
--------
L
G
E
Q
I
G
R
G
N
F
G
-----
E
V
F
S
G
R
L
R
A
---
D
---
N
-
T
L
V
A
V
K
S
C
R
E
-
T
--
L
---
P
---
P
D
LKA
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
-
Q
P
-
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
-
T
E
-
G
-
A
-
R
-
L
R
-
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
--
A
S
-
G
-
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
-
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
------------
556
HHSearch
59.93
35%
-54
- C3 -
-
3CBL
8.4
-
A:
[7-375]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
-
E
L
L
-
V
-------
H
S
G
D
F
L
V
R
E
S
-
Q
---
Q
E
Y
V
L
S
V
--------------
P
R
H
F
I
I
-----
N
L
-
Y
R
L
----
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
P
L
-----
V
--
V
L
H
R
---------
A
-------
V
---------------
P
---------------
K
-
D
K
W
V
L
N
H
E
-------
D
L
V
--------
L
G
E
Q
I
G
R
G
N
F
G
-----
E
V
F
S
G
R
L
R
A
D--
N
---
T
-
L
-
V
A
V
K
S
C
R
E
T
L
PP
D
---
L
---
K
A
---
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
-
Q
P
-
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
-
T
E
-
G
-
A
-
R
-
L
R
-
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
--
A
S
-
G
G
L
-
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
-
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
--
181
Blastp_CBE
59.88
39%
16
- C3 -
-
3VS6
7.9
-
HCK_HUMAN
A:
[11-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
-
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
-
M
L
G
S
F
M
I
R
D
S
E
T
T
-
K
G
S
Y
S
L
S
V
RD
Y
D
P
R
Q
G
D
---
T
-
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
--
P
C
M
S
S
K
P
Q
K
P
W
E
K
D
------------------------------------------
A
W
E
I
P
R
E
-------
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
-----
E
V
W
M
A
T
Y
N
K
---
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
---
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
D
-
E
-
G
-
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
-----------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
------
194
Blastp_CBE
59.87
39%
10
- C3 -
-
3VRZ
9.7
-
HCK_HUMAN
B:
[11-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
-
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
-
M
L
G
S
F
M
I
R
D
S
E
T
T
-
K
G
S
Y
S
L
S
V
RD
Y
D
P
R
Q
G
D
---
T
-
V
K
H
Y
K
I
R
T
----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
--
P
C
M
S
S
K
P
Q
K
P
W
E
K
D
------------------------------------------
A
W
E
I
P
R
E
-------
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
-----
E
V
W
M
A
T
Y
N
K
---
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
---
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
D
-
E
-
G
-
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
-----------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
------
187
Blastp_CBE
59.85
39%
18
- C3 -
-
3VS3
9.4
-
HCK_HUMAN
A:
[11-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
-
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
-
M
L
G
S
F
M
I
R
D
S
E
T
T
-
K
G
S
Y
S
L
S
V
RD
Y
D
P
R
Q
G
D
---
T
-
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
--
P
C
M
S
S
K
P
Q
K
P
W
E
K
D
------------------------------------------
A
W
E
I
P
R
E
-------
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
-----
E
V
W
M
A
T
Y
N
K
---
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
---
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
D
-
E
-
G
-
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
-----------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
------
203
Blastp_CBE
59.81
39%
16
- C3 -
-
2C0I
11.6
-
HCK_HUMAN
A:
[11-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
-
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
-
M
L
G
S
F
M
I
R
D
S
E
T
T
-
K
G
S
Y
S
L
S
V
RD
Y
D
P
R
Q
G
D
---
T
-
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
--
P
C
M
S
S
K
P
Q
K
P
W
E
K
D
------------------------------------------
A
W
E
I
P
R
E
-------
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
-----
E
V
W
M
A
T
Y
N
K
---
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
---
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
D
-
E
-
G
-
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
------
426
Blastp_CBE
59.80
35%
-42
- C3 -
-
3BKB
8.5
-
A:
[4-365]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
V
Q
K
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
-
E
L
L
-
V
-
H
-
S
-
G
-
D
---
F
L
V
R
E
S
-
Q
G
-
K
Q
E
Y
V
L
S
V
--
L
W
------
D
G
L
-
P
R
H
F
I
I
Q
S
L
--
D
N
L
Y
R
L
E
G
E
G
F
P
S
I
P
L
L
I
D
H
-------
L
L
S
T
-
Q
Q
--
P
L
T
K
K
S
G
V
V
L
H
R
A
--------
V
---------------
P
---------------
K
-
D
K
W
V
L
N
H
E
-------
D
L
V
--------
L
G
E
Q
I
G
R
G
N
F
G
-----
E
V
F
S
G
R
L
R
A
---
D
---
N
-
T
L
V
A
V
K
S
C
R
E
-
T
--
L
---
P
---
P
D
LKA
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
-
Q
P
-
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
-
T
E
-
G
-
A
-
R
-
L
R
-
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
--
A
S
-
G
-
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
-
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
------------
198
Blastp_CBE
59.77
39%
11
- C3 -
-
2C0T
10.4
-
HCK_HUMAN
B:
[11-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
-
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
-
M
L
G
S
F
M
I
R
D
S
E
T
T
-
K
G
S
Y
S
L
S
V
RD
Y
D
P
R
Q
G
D
---
T
-
V
K
H
Y
K
I
R
T
----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
--
P
C
M
S
S
K
P
Q
K
P
W
E
K
D
------------------------------------------
A
W
E
I
P
R
E
-------
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
-----
E
V
W
M
A
T
Y
N
K
---
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
---
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
D
-
E
-
G
-
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
------
196
Blastp_CBE
59.65
39%
14
- C3 -
-
3VRY
9.1
-
HCK_HUMAN
B:
[11-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
-
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
-
M
L
G
S
F
M
I
R
D
S
E
T
T
-
K
G
S
Y
S
L
S
V
RD
Y
D
P
R
Q
G
D
---
T
-
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
--
P
C
M
S
S
K
P
Q
K
P
W
E
K
D
------------------------------------------
A
W
E
I
P
R
E
-------
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
-----
E
V
W
M
A
T
Y
N
K
---
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
---
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
D
-
E
-
G
-
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
-----------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
------
201
Blastp_CBE
59.31
39%
17
- C3 -
-
2C0O
10.3
-
HCK_HUMAN
A:
[11-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
-
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
-
M
L
G
S
F
M
I
R
D
S
E
T
T
-
K
G
S
Y
S
L
S
V
RD
Y
D
P
R
Q
G
D
---
T
-
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
--
P
C
M
S
S
K
P
Q
K
P
W
E
K
D
------------------------------------------
A
W
E
I
P
R
E
-------
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
-----
E
V
W
M
A
T
Y
N
K
---
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
---
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
D
-
E
-
G
-
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
------
188
Blastp_CBE
59.22
39%
19
- C3 -
-
3VS2
7.8
-
HCK_HUMAN
B:
[11-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
-
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
-
M
L
G
S
F
M
I
R
D
S
E
T
T
-
K
G
S
Y
S
L
S
V
RD
Y
D
P
R
Q
G
D
---
T
-
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
--
P
C
M
S
S
K
P
Q
K
P
W
E
K
D
------------------------------------------
A
W
E
I
P
R
E
-------
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
-----
E
V
W
M
A
T
Y
N
K
---
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
---
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
D
-
E
-
G
-
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
------
186
Blastp_CBE
59.18
39%
10
- C3 -
-
3VS3
9.3
-
HCK_HUMAN
B:
[11-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
-
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
-
M
L
G
S
F
M
I
R
D
S
E
T
T
-
K
G
S
Y
S
L
S
V
RD
Y
D
P
R
Q
G
D
---
T
-
V
K
H
Y
K
I
R
T
-----
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
--
P
C
M
S
S
K
P
Q
K
P
W
E
K
D
------------------------------------------
A
W
E
I
P
R
E
-------
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
-----
E
V
W
M
A
T
Y
N
K
---
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
---
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
D
-
E
-
G
-
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
---------------
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
------
184
Blastp_CBE
59.03
39%
14
- C3 -
-
3VS4
8.7
-
HCK_HUMAN
B:
[11-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
-
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
-
M
L
G
S
F
M
I
R
D
S
E
T
T
-
K
G
S
Y
S
L
S
V
RD
Y
D
P
R
Q
G
D
---
T
-
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
--
P
C
M
S
S
K
P
Q
K
P
W
E
K
D
------------------------------------------
A
W
E
I
P
R
E
-------
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
-----
E
V
W
M
A
T
Y
N
K
---
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
---
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
D
-
E
-
G
-
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
-----------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
------
180
Blastp_CBE
58.98
39%
13
- C3 -
-
3VS6
8.1
-
HCK_HUMAN
B:
[11-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
-
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
-
M
L
G
S
F
M
I
R
D
S
E
T
T
-
K
G
S
Y
S
L
S
V
RD
Y
D
P
R
Q
G
D
---
T
-
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
--
P
C
M
S
S
K
P
Q
K
P
W
E
K
D
------------------------------------------
A
W
E
I
P
R
E
-------
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
-----
E
V
W
M
A
T
Y
N
K
---
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
---
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
D
-
E
-
G
-
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
-----------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
------
213
Blastp_CBE
58.95
39%
21
- C3 -
-
1AD5
4.4
-
HCK_HUMAN
B:
[5-425]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
-
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
-
M
L
G
S
F
M
I
R
D
S
E
T
T
-
K
G
S
Y
S
L
S
V
RD
Y
D
P
R
Q
G
D
---
T
-
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
--
P
C
M
S
S
K
P
Q
K
P
W
E
K
D
------------------------------------------
A
W
E
I
P
R
E
-------
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
-----
E
V
W
M
A
T
Y
N
K
---
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
---
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
D
-
E
-
G
-
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
-------------
V
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
------
195
Blastp_CBE
58.89
39%
13
- C3 -
-
3VRZ
9.7
-
HCK_HUMAN
A:
[11-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
-
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
-
M
L
G
S
F
M
I
R
D
S
E
T
T
-
K
G
S
Y
S
L
S
V
RD
Y
D
P
R
Q
G
D
---
T
-
V
K
H
Y
K
I
R
T
----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
--
P
C
M
S
S
K
P
Q
K
P
W
E
K
D
------------------------------------------
A
W
E
I
P
R
E
-------
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
-----
E
V
W
M
A
T
Y
N
K
---
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
---
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
D
-
E
-
G
-
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
------
161
Blastp_CBE
58.85
58%
-151
- C3 -
-
4KIO
4.6
-
ITK_HUMAN
C:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
R
E
G
A
--
M
---
S
---
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
--------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
202
Blastp_CBE
58.83
39%
19
- C3 -
-
2C0I
11.2
-
HCK_HUMAN
B:
[11-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
-
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
-
M
L
G
S
F
M
I
R
D
S
E
T
T
-
K
G
S
Y
S
L
S
V
RD
Y
D
P
R
Q
G
D
---
T
-
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
--
P
C
M
S
S
K
P
Q
K
P
W
E
K
D
------------------------------------------
A
W
E
I
P
R
E
-------
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
-----
E
V
W
M
A
T
Y
N
K
---
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
---
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
D
-
E
-
G
-
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
------
189
Blastp_CBE
58.70
39%
13
- C3 -
-
3VS2
9.1
-
HCK_HUMAN
A:
[11-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
-
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
-
M
L
G
S
F
M
I
R
D
S
E
T
T
-
K
G
S
Y
S
L
S
V
RD
Y
D
P
R
Q
G
D
---
T
-
V
K
H
Y
K
I
R
T
L
---
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
--
P
C
M
S
S
K
P
Q
K
P
W
E
K
D
------------------------------------------
A
W
E
I
P
R
E
-------
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
-----
E
V
W
M
A
T
Y
N
K
---
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
---
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
D
-
E
-
G
-
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
------
166
Blastp_CBE
58.69
42%
-9
- C3 -
-
1OPL
9.4
-
ABL1_HUMAN
B:
[140-505]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
-
Y
L
L
-
S
-
S
---
G
-
I
N
G
S
F
L
V
R
E
S
E
S
S
-
P
G
Q
R
S
I
S
L
--
R
Y
------
E
G
R
-
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
--
P
A
P
----------------------------------------------------
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
555
HHSearch
58.66
42%
-17
- C3 -
-
4XEY
7.8
-
ABL1_HUMAN
B:
[7-384]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
-
Y
L
L
-
S
-
S
---
G
-
I
N
G
S
F
L
V
R
E
S
-
E
S
S
P
G
Q
R
S
I
S
L
--
R
Y
E
------
G
R
-
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
---
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
--
P
A
P
K
-------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
-----------
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
---
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
-
N
R
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
--
197
Blastp_CBE
58.63
39%
10
- C3 -
-
3VRY
8.9
-
HCK_HUMAN
A:
[11-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
-
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
-
M
L
G
S
F
M
I
R
D
S
E
T
T
-
K
G
S
Y
S
L
S
V
RD
Y
D
P
R
Q
G
D
---
T
-
V
K
H
Y
K
I
R
------
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
--
P
C
M
S
S
K
P
Q
K
P
W
E
K
D
------------------------------------------
A
W
E
I
P
R
E
-------
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
-----
E
V
W
M
A
T
Y
N
K
---
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
---
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
D
-
E
-
G
-
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
-----------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
------
123
Blastp_CBE
58.62
59%
-148
- C3 -
-
3QGW
6.2
-
ITK_HUMAN
A:
[24-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
K
E
G
S
--
M
---
S
---
E
D
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
----------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
214
Blastp_CBE
58.52
39%
22
- C3 -
-
1AD5
4.6
-
HCK_HUMAN
A:
[5-425]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
-
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
-
M
L
G
S
F
M
I
R
D
S
E
T
T
-
K
G
S
Y
S
L
S
V
RD
Y
D
P
R
Q
G
D
---
T
-
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
--
P
C
M
S
S
K
P
Q
K
P
W
E
K
D
------------------------------------------
A
W
E
I
P
R
E
-------
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
-----
E
V
W
M
A
T
Y
N
K
---
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
---
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
D
-
E
-
G
-
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
-------------
V
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
------
193
Blastp_CBE
58.52
39%
12
- C3 -
-
3VS0
9.1
-
HCK_HUMAN
A:
[11-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
-
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
-
M
L
G
S
F
M
I
R
D
S
E
T
T
-
K
G
S
Y
S
L
S
V
RD
Y
D
P
R
Q
G
D
---
T
-
V
K
H
Y
K
I
R
-----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
--
P
C
M
S
S
K
P
Q
K
P
W
E
K
D
------------------------------------------
A
W
E
I
P
R
E
-------
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
-----
E
V
W
M
A
T
Y
N
K
---
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
---
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
D
-
E
-
G
-
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
------
182
Blastp_CBE
58.50
39%
6
- C3 -
-
3VS5
8.6
-
HCK_HUMAN
B:
[11-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
-
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
-
M
L
G
S
F
M
I
R
D
S
E
T
T
-
K
G
S
Y
S
L
S
V
RD
Y
D
P
R
Q
G
D
---
T
-
V
K
H
Y
K
I
R
------
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
--
P
C
M
S
S
K
P
Q
K
P
W
E
K
D
------------------------------------------
A
W
E
I
P
R
E
-------
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
-----
E
V
W
M
A
T
Y
N
K
---
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
---
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
D
-
E
-
G
-
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
------
199
Blastp_CBE
58.48
39%
11
- C3 -
-
2C0T
11.2
-
HCK_HUMAN
A:
[11-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
-
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
-
M
L
G
S
F
M
I
R
D
S
E
T
T
-
K
G
S
Y
S
L
S
V
RD
Y
D
P
R
Q
G
D
---
T
-
V
K
H
Y
K
I
R
------
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
--
P
C
M
S
S
K
P
Q
K
P
W
E
K
D
------------------------------------------
A
W
E
I
P
R
E
-------
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
-----
E
V
W
M
A
T
Y
N
K
---
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
---
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
D
-
E
-
G
-
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
------
137
Blastp_CBE
58.27
58%
-157
- C3 -
-
3V8W
3.3
-
ITK_HUMAN
A:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
G
--
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
R
-
G
A
--
M
---
S
---
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
-
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
200
Blastp_CBE
58.17
39%
19
- C3 -
-
2C0O
10.5
-
HCK_HUMAN
B:
[11-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
-
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
-
M
L
G
S
F
M
I
R
D
S
E
T
T
-
K
G
S
Y
S
L
S
V
RD
Y
D
P
R
Q
G
D
---
T
-
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
--
P
C
M
S
S
K
P
Q
K
P
W
E
K
D
------------------------------------------
A
W
E
I
P
R
E
-------
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
-----
E
V
W
M
A
T
Y
N
K
---
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
---
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
D
-
E
-
G
-
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
------
183
Blastp_CBE
58.04
39%
14
- C3 -
-
3VS5
8.5
-
HCK_HUMAN
A:
[11-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
-
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
-
M
L
G
S
F
M
I
R
D
S
E
T
T
-
K
G
S
Y
S
L
S
V
RD
Y
D
P
R
Q
G
D
---
T
-
V
K
H
Y
K
I
R
T
----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
--
P
C
M
S
S
K
P
Q
K
P
W
E
K
D
------------------------------------------
A
W
E
I
P
R
E
-------
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
-----
E
V
W
M
A
T
Y
N
K
---
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
---
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
D
-
E
-
G
-
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
------
159
Blastp_CBE
58.03
58%
-145
- C3 -
-
4L7S
6.8
-
ITK_HUMAN
A:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
R
E
G
A
--
M
---
S
---
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
---------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
185
Blastp_CBE
57.95
39%
10
- C3 -
-
3VS4
8.5
-
HCK_HUMAN
A:
[11-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
-
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
-
M
L
G
S
F
M
I
R
D
S
E
T
T
-
K
G
S
Y
S
L
S
V
RD
Y
D
P
R
Q
G
D
---
T
-
V
K
H
Y
K
I
R
------
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
--
P
C
M
S
S
K
P
Q
K
P
W
E
K
D
------------------------------------------
A
W
E
I
P
R
E
-------
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
-----
E
V
W
M
A
T
Y
N
K
---
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
---
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
D
-
E
-
G
-
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
----------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
------
190
Blastp_CBE
57.96
39%
19
- C3 -
-
3VS1
8.8
-
HCK_HUMAN
B:
[11-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
-
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
-
M
L
G
S
F
M
I
R
D
S
E
T
T
-
K
G
S
Y
S
L
S
V
RD
Y
D
P
R
Q
G
D
---
T
-
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
--
P
C
M
S
S
K
P
Q
K
P
W
E
K
D
------------------------------------------
A
W
E
I
P
R
E
-------
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
-----
E
V
W
M
A
T
Y
N
K
---
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
---
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
D
-
E
-
G
-
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
------
140
Blastp_CBE
57.95
58%
-154
- C3 -
-
3V5L
7.4
-
D:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
-
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
R
--
A
--
M
---
S
---
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
---------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
425
Blastp_CBE
57.83
35%
-46
- C3 -
-
3CBL
8.4
-
A:
[1-365]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
I
P
E
V
Q
K
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
-
E
L
L
-
V
-
H
-
S
-
G
-
D
---
F
L
V
R
E
S
-
Q
---
Q
E
Y
V
L
S
V
--------------
P
R
H
F
I
I
------
N
L
Y
R
L
----
F
P
S
I
P
L
L
I
D
H
-------
L
L
S
T
-
Q
Q
--
P
L
-----
V
V
L
H
R
A
--------
V
---------------
P
---------------
K
-
D
K
W
V
L
N
H
E
-------
D
L
V
--------
L
G
E
Q
I
G
R
G
N
F
G
-----
E
V
F
S
G
R
L
R
A
---
D
---
N
-
T
L
V
A
V
K
S
C
R
E
-
T
--
L
---
P
---
P
D
LKA
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
-
Q
P
-
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
-
T
E
-
G
-
A
-
R
-
L
R
-
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
--
A
S
-
G
-
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
-
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
------------
136
Blastp_CBE
57.85
58%
-157
- C3 -
-
3V8W
2.9
-
B:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
G
--
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
R
-----
M
---
S
---
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
141
Blastp_CBE
57.84
58%
-152
- C3 -
-
3V5L
7.2
-
ITK_HUMAN
C:
[4-262]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
---
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
R
E
G
A
--
M
---
S
---
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
--------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
----
211
Blastp_CBE
57.83
39%
18
- C3 -
-
2HCK
5.7
-
HCK_HUMAN
B:
[5-425]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
-
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
-
M
L
G
S
F
M
I
R
D
S
E
T
T
-
K
G
S
Y
S
L
S
V
RD
Y
D
P
R
Q
G
D
---
T
-
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
--
P
C
M
S
S
K
P
Q
K
P
W
E
K
D
------------------------------------------
A
W
E
I
P
R
E
-------
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
-----
E
V
W
M
A
T
Y
N
K
---
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
---
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
D
-
E
-
G
-
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
-------------
V
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
------
158
Blastp_CBE
57.82
58%
-147
- C3 -
-
4L7S
6.0
-
B:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
R
E
G
A
--
M
---
S
---
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
---------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
174
Blastp_CBE
57.78
39%
20
- C3 -
-
4LUE
9.7
-
HCK_HUMAN
B:
[11-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
-
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
-
M
L
G
S
F
M
I
R
D
S
E
T
T
-
K
G
S
Y
S
L
S
V
RD
Y
D
P
R
Q
G
D
---
T
-
V
K
H
Y
K
I
R
T
----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
--
P
C
M
S
S
K
P
Q
K
P
W
E
K
D
------------------------------------------
A
W
E
I
P
R
E
-------
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
-----
E
V
W
M
A
T
Y
N
K
---
H
---
T
-
K
-
V
A
V
K
T
M
K
P
-------------------
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
D
-
E
-
G
-
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
------------------
P
I
K
W
T
A
P
E
A
I
N
---
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
------
144
Blastp_CBE
57.76
58%
-163
- C3 -
-
3V5J
6.8
-
B:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
G
--
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
------
M
---
S
---
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
178
Blastp_CBE
57.64
39%
16
- C3 -
-
3VS7
6.9
-
HCK_HUMAN
B:
[11-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
-
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
-
M
L
G
S
F
M
I
R
D
S
E
T
T
-
K
G
S
Y
S
L
S
V
RD
Y
D
P
R
Q
G
D
---
T
-
V
K
H
Y
K
I
R
T
-----
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
--
P
C
M
S
S
K
P
Q
K
P
W
E
K
D
------------------------------------------
A
W
E
I
P
R
E
-------
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
-----
E
V
W
M
A
T
Y
N
K
---
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
---
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
D
-
E
-
G
-
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
------
145
Blastp_CBE
57.52
58%
-155
- C3 -
-
3V5J
6.6
-
ITK_HUMAN
A:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
-
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
R
E
G
-------
S
---
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
-
R
S
-
N
S
E
V
V
E
D
I
S
T
G
-
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
154
Blastp_CBE
57.48
58%
-151
- C3 -
-
4PP9
5.5
-
B:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
R
E
G
A
--
M
---
S
---
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
121
Blastp_CBE
57.48
59%
-142
- C3 -
-
3QGY
6.8
-
ITK_HUMAN
A:
[24-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
K
E
G
S
--
M
---
S
---
E
D
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
179
Blastp_CBE
57.37
39%
27
- C3 -
-
3VS7
6.9
-
HCK_HUMAN
A:
[11-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
-
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
-
M
L
G
S
F
M
I
R
D
S
E
T
T
-
K
G
S
Y
S
L
S
V
RD
Y
D
P
R
Q
G
D
---
T
-
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
--
P
C
M
S
S
K
P
Q
K
P
W
E
K
D
------------------------------------------
A
W
E
I
P
R
E
-------
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
-----
E
V
W
M
A
T
Y
N
K
---
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
---
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
D
-
E
-
G
-
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
-------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
------
155
Blastp_CBE
57.37
58%
-146
- C3 -
-
4PP9
5.0
-
ITK_HUMAN
A:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
R
E
G
A
--
M
---
S
---
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
124
Blastp_CBE
57.29
59%
-151
- C3 -
-
4RFM
6.6
-
A:
[4-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
R
E
G
A
--
M
---
S
---
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
-------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
-----
134
Blastp_CBE
57.25
58%
-150
- C3 -
-
1SM2
8.3
-
B:
[2-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
R
E
G
A
--
M
---
S
---
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
212
Blastp_CBE
57.23
39%
21
- C3 -
-
2HCK
6.4
-
HCK_HUMAN
A:
[5-425]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
-
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
-
M
L
G
S
F
M
I
R
D
S
E
T
T
-
K
G
S
Y
S
L
S
V
RD
Y
D
P
R
Q
G
D
---
T
-
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
--
P
C
M
S
S
K
P
Q
K
P
W
E
K
D
------------------------------------------
A
W
E
I
P
R
E
-------
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
-----
E
V
W
M
A
T
Y
N
K
---
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
---
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
D
-
E
-
G
-
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
-------------
V
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
------
133
Blastp_CBE
57.04
58%
-141
- C3 -
-
1SNU
7.4
-
ITK_HUMAN
A:
[2-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
R
E
G
A
--
M
---
S
---
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
132
Blastp_CBE
57.00
58%
-147
- C3 -
-
1SNU
7.3
-
B:
[2-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
R
E
G
A
--
M
---
S
---
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
175
Blastp_CBE
56.98
39%
18
- C3 -
-
4LUE
9.7
-
HCK_HUMAN
A:
[11-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
-
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
-
M
L
G
S
F
M
I
R
D
S
E
T
T
-
K
G
S
Y
S
L
S
V
RD
Y
D
P
R
Q
G
D
---
T
-
V
K
H
Y
K
I
R
T
----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
--
P
C
M
S
S
K
P
Q
K
P
W
E
K
D
------------------------------------------
A
W
E
I
P
R
E
-------
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
-----
E
V
W
M
A
T
Y
N
K
---
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
-----------------
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
D
-
E
-
G
-
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
------
160
Blastp_CBE
56.98
58%
-151
- C3 -
-
4KIO
4.5
-
D:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
----------
S
---
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
130
Blastp_CBE
56.98
59%
-158
- C3 -
-
3MIY
6.7
-
B:
[4-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
G
--
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
----------
S
---
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
-----
162
Blastp_CBE
56.83
58%
-160
- C3 -
-
4KIO
4.9
-
ITK_HUMAN
B:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
---
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
---------------
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
---------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
191
Blastp_CBE
56.81
39%
16
- C3 -
-
3VS1
8.2
-
HCK_HUMAN
A:
[11-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
-
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
-
M
L
G
S
F
M
I
R
D
S
E
T
T
-
K
G
S
Y
S
L
S
V
RD
Y
D
P
R
Q
G
D
---
T
-
V
K
H
Y
K
I
R
---------
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
--
P
C
M
S
S
K
P
Q
K
P
W
E
K
D
------------------------------------------
A
W
E
I
P
R
E
-------
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
-----
E
V
W
M
A
T
Y
N
K
---
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
---
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
D
-
E
-
G
-
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
------
138
Blastp_CBE
56.81
58%
-151
- C3 -
-
3V8T
6.3
-
B:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
G
--
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
---
A
--
M
---
S
---
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
---------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
126
Blastp_CBE
56.63
59%
-147
- C3 -
-
4MF1
4.9
-
B:
[4-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
G
--
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
---
A
--
M
---
S
---
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
-------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
-----
135
Blastp_CBE
56.57
58%
-145
- C3 -
-
1SM2
7.5
-
ITK_HUMAN
A:
[2-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
R
E
G
A
--
M
---
S
---
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
163
Blastp_CBE
56.48
58%
-155
- C3 -
-
4KIO
5.8
-
ITK_HUMAN
A:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
---
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
--------------
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
---------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
122
Blastp_CBE
56.40
59%
-143
- C3 -
-
3QGW
5.0
-
B:
[24-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
K
E
G
S
--
M
---
S
---
E
D
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
----
557
HHSearch
56.28
32%
-22
- C3 -
-
4K2R
5.8
-
ZAP70_HUMAN
A:
[156-599]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
H
E
R
M
P
W
Y
H
S
S
L
T
R
E
E
A
E
-
R
K
L
-
Y
-
S
-
G
-
A
Q
T
D
G
K
F
L
L
R
P
R
-
K
E
-
Q
G
T
Y
A
L
S
L
--
I
Y
G
------
K
T
-
V
Y
H
Y
L
I
S
Q
D
K
A
G
K
Y
C
I
P
E
G
T
K
F
D
T
L
W
Q
L
V
E
Y
L
K
L
K
A
D
G
L
I
Y
C
L
K
E
--
A
C
P
N
S
---------DKPRPMP
M
---------------
D
TSVYESPYSDPEELK
D
K
K
L
F
L
K
R
D
N
-------
L
L
I
--------
A
D
I
E
L
G
C
G
N
F
G
-----
S
V
R
Q
G
V
Y
R
M
RKK
Q
---
I
-
D
-
V
A
I
K
V
L
K
Q
G
T
--
E
KA-
D
---
T
E
---
E
M
M
R
E
A
Q
I
M
H
Q
L
D
N
P
Y
I
V
R
L
I
G
V
C
Q
A
--
E
A
-
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
-
G
K
-
R
-
E
-
E
-
I
P
-
V
S
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
N
L
A
A
R
N
V
L
L
V
N
R
H
Y
A
K
I
S
D
F
G
L
S
--------------------
W
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
Q
K
P
Y
K
K
M
K
-
G
P
E
V
M
A
F
I
E
Q
G
K
R
M
E
C
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
Y
S
--
215
Blastp_CBE
56.32
43%
-10
- C3 -
-
4XEY
7.8
-
ABL1_HUMAN
B:
[7-371]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
-
Y
L
L
-
S
-
S
---
G
-
I
N
G
S
F
L
V
R
E
S
E
S
S
-
P
G
Q
R
S
I
S
L
--------
R
Y
E
G
R
-
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
---
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
--
P
A
P
K
-------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
-----------
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
---
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
125
Blastp_CBE
56.32
59%
-141
- C3 -
-
4PQN
5.9
-
A:
[4-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
G
--
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
R
E
G
A
--
M
---
S
---
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
----------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
-----
142
Blastp_CBE
56.28
58%
-153
- C3 -
-
3V5L
7.5
-
ITK_HUMAN
B:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
---------
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
R
---------
S
---
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
---------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
131
Blastp_CBE
56.18
59%
-155
- C3 -
-
3MIY
6.6
-
ITK_HUMAN
A:
[4-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
G
--
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
----------
S
---
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
-----
143
Blastp_CBE
56.10
58%
-150
- C3 -
-
3V5L
7.5
-
ITK_HUMAN
A:
[4-262]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
G
--
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
------
M
---
S
---
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
---------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
----
177
Blastp_CBE
56.07
39%
24
- C3 -
-
4LUD
4.7
-
HCK_HUMAN
A:
[11-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
----
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
-
M
L
G
S
F
M
I
R
D
S
E
T
T
-
K
G
S
Y
S
L
S
V
RD
Y
D
P
R
Q
G
D
---
T
-
V
K
H
Y
K
I
R
T
L
D
--
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
--
P
C
M
S
S
K
P
Q
K
P
W
E
K
D
------------------------------------------
A
W
E
I
P
R
E
-------
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
-----
E
V
W
M
A
T
Y
N
K
---
H
---
T
-
K
-
V
A
V
K
T
M
K
P
--------
S
---
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
D
-
E
-
G
-
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
----
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
------
139
Blastp_CBE
56.07
58%
-153
- C3 -
-
3V8T
6.2
-
ITK_HUMAN
A:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
---
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
R
E
G
A
--
M
---
S
---
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-------
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
127
Blastp_CBE
56.00
59%
-149
- C3 -
-
4MF1
4.5
-
ITK_HUMAN
A:
[4-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
G
--
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
---
A
--
M
---
S
---
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
-----
120
Blastp_CBE
55.68
59%
-134
- C3 -
-
3QGY
5.3
-
B:
[24-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
K
E
G
S
--
M
---
S
---
E
D
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
---------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
----
424
Blastp_CBE
55.28
35%
-43
- C3 -
-
4E93
5.3
-
A:
[1-365]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
I
P
E
V
Q
K
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
-
E
L
L
-
V
-
H
-
S
-
G
-
D
---
F
L
V
R
E
S
-
Q
---
Q
E
Y
V
L
S
V
--
L
W
------
D
G
L
-
P
R
H
F
I
I
Q
S
L
--
D
N
L
Y
R
L
E
G
E
G
F
P
S
I
P
L
L
I
D
H
-------
L
L
S
T
-
Q
Q
--
P
L
T
K
K
S
G
V
V
L
H
R
A
--------
V
---------------
P
---------------
K
-
D
K
W
V
L
N
H
E
-------
D
L
V
--------
L
G
E
Q
I
G
R
G
N
F
G
-----
E
V
F
S
G
R
L
R
A
---
D
---
N
-
T
L
V
A
V
K
S
C
R
E
-
T
--
L
---
P
---
P
D
LKA
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
-
Q
P
-
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
-
T
E
-
G
-
A
-
R
-
L
R
-
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
------------------
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
-
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
------------
176
Blastp_CBE
55.14
39%
14
- C3 -
-
4LUD
6.1
-
HCK_HUMAN
B:
[11-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
-
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
-
N
-
M
L
G
S
F
M
I
R
D
S
E
T
----
S
Y
S
L
S
V
RD
Y
D
P
R
Q
G
D
---
T
-
V
K
H
Y
K
I
-----------------
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
--
P
C
M
S
S
K
P
Q
K
P
W
E
K
D
------------------------------------------
A
W
E
I
P
R
E
-------
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
-----
E
V
W
M
A
T
Y
N
K
---
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
-------
S
---
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
D
-
E
-
G
-
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
------
525
Fugue
55.07
35%
-40
- C3 -
-
3CD3
8.4
-
A:
[1-376]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
I
P
E
V
Q
K
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
-
E
L
L
-
V
-
H
-
S
-
G
----
D
F
L
V
R
E
S
-
Q
E
----
Y
V
L
S
V
------------------------
P
R
H
F
I
I
N
L
Y
R
L
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
P
L
S
G
V
V
L
H
--
R
A
V
P
K
D
K
--------------------------------------------------
W
V
L
N
H
E
-------
D
L
V
--------
L
G
E
Q
I
G
R
G
N
F
G
-----
E
V
F
S
G
R
L
R
A
---
D
---
N
T
L
-
V
A
V
K
S
C
R
P
D
L
--
K
---
A
---
K
-----
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
-
Q
P
-
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
-
T
E
-
G
-
A
-
R
-
L
R
-
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
A
A
--
S
G
-
G
-
L
-
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
-
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
H
-
129
Blastp_CBE
54.85
59%
-155
- C3 -
-
3MJ1
6.4
-
A:
[4-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
G
--
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
----------------------
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
-
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
-----
559
HHSearch
54.46
33%
12
- C3 -
-
4FL2
6.1
-
KSYK_HUMAN
A:
[163-633]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
H
E
K
M
P
W
F
H
G
K
I
S
R
E
E
S
E
-
Q
I
V
-
L
I
G
-
S
-
K
-
T
N
G
K
F
L
I
R
A
R
-
D
N
-
N
G
S
Y
A
L
C
L
--
L
H
E
------
G
K
-
V
L
H
Y
R
I
D
K
D
K
T
G
K
L
S
I
P
E
G
K
K
F
D
T
L
W
Q
L
V
E
H
Y
S
Y
K
A
D
G
L
L
R
V
L
T
V
--
P
C
Q
K
I
G
T
---------------QREALPMDTEVYESP
Y
---------------
A
-
D
P
E
E
I
R
P
K
EVYLDRK
L
L
T
L-------
E
D
K
E
L
G
S
G
N
F
G
-----
T
V
K
K
G
Y
Y
Q
M
---
K
KVV
K
-
T
-
V
A
V
K
I
L
K
N
E
A
--
N
---
D
PAL
K
D
---
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
--
E
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
-
Q
N
---
R
-
H
-
V
K
-
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
YK
A
Q
-
T
-
H
-
G
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
--
466
Blastp_CBE
53.92
43%
-64
- C3 -
-
3KMM
7.9
-
LCK_HUMAN
A:
[17-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
R
E
-------
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
-----
E
V
W
M
G
Y
Y
N
G
---
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
---
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P
-
S
-
G
I
K
-
L
T
-
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
-
E
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
------
437
Blastp_CBE
53.60
43%
-61
- C3 -
-
3ACK
5.3
-
LCK_HUMAN
A:
[14-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
R
E
-------
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
-----
E
V
W
M
G
Y
Y
N
G
---
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
---
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P
-
S
-
G
I
K
-
L
T
-
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
-
E
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
------
467
Blastp_CBE
53.56
43%
-65
- C3 -
-
2OFU
8.4
-
LCK_HUMAN
A:
[10-268]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
R
E
-------
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
-----
E
V
W
M
G
Y
Y
N
G
---
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
---
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P
-
S
-
G
I
K
-
L
T
-
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
-
E
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
------
443
Blastp_CBE
53.55
43%
-61
- C3 -
-
3AC2
5.7
-
LCK_HUMAN
A:
[14-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
R
E
-------
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
-----
E
V
W
M
G
Y
Y
N
G
---
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
---
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P
-
S
-
G
I
K
-
L
T
-
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
-
E
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
------
438
Blastp_CBE
53.54
43%
-64
- C3 -
-
3ACJ
4.9
-
LCK_HUMAN
A:
[14-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
R
E
-------
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
-----
E
V
W
M
G
Y
Y
N
G
---
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
---
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P
-
S
-
G
I
K
-
L
T
-
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
-
E
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
------
461
Blastp_CBE
53.52
43%
-69
- C3 -
-
1QPJ
8.9
-
LCK_HUMAN
A:
[8-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
R
E
-------
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
-----
E
V
W
M
G
Y
Y
N
G
---
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
---
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P
-
S
-
G
I
K
-
L
T
-
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
-
E
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
------
147
Blastp_CBE
53.50
58%
-147
- C3 -
-
4QD6
4.9
-
ITK_HUMAN
A:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
----------
S
---
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
---------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
335
Blastp_CBE
53.35
43%
-63
- C3 -
-
2OF4
6.4
-
LCK_HUMAN
A:
[8-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
R
E
-------
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
-----
E
V
W
M
G
Y
Y
N
G
---
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
---
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P
-
S
-
G
I
K
-
L
T
-
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
-
E
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
------
440
Blastp_CBE
53.24
43%
-61
- C3 -
-
3AC5
7.3
-
LCK_HUMAN
A:
[14-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
R
E
-------
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
-----
E
V
W
M
G
Y
Y
N
G
---
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
---
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P
-
S
-
G
I
K
-
L
T
-
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
-
E
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
------
436
Blastp_CBE
53.27
43%
-65
- C3 -
-
3AD4
5.0
-
LCK_HUMAN
A:
[14-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
R
E
-------
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
-----
E
V
W
M
G
Y
Y
N
G
---
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
---
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P
-
S
-
G
I
K
-
L
T
-
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
-
E
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
------
327
Blastp_CBE
53.24
43%
-63
- C3 -
-
2PL0
10.4
-
LCK_HUMAN
A:
[18-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
R
E
-------
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
-----
E
V
W
M
G
Y
Y
N
G
---
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
---
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P
-
S
-
G
I
K
-
L
T
-
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
-
E
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
------
479
Blastp_CBE
53.23
43%
-62
- C3 -
-
3U4W
10.9
-
SRC_CHICK
A:
[1-260]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
-
Q
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
444
Blastp_CBE
53.21
43%
-62
- C3 -
-
3AC1
5.4
-
LCK_HUMAN
A:
[14-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
R
E
-------
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
-----
E
V
W
M
G
Y
Y
N
G
---
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
---
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P
-
S
-
G
I
K
-
L
T
-
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
-
E
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
------
472
Blastp_CBE
53.20
43%
-60
- C3 -
-
3BYO
9.5
-
?
A:
[8-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
R
E
-------
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
-----
E
V
W
M
G
Y
Y
N
G
---
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
---
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P
-
S
-
G
I
K
-
L
T
-
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
-
E
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
------
439
Blastp_CBE
53.18
43%
-61
- C3 -
-
3AC8
6.2
-
LCK_HUMAN
A:
[14-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
R
E
-------
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
-----
E
V
W
M
G
Y
Y
N
G
---
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
---
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P
-
S
-
G
I
K
-
L
T
-
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
-
E
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
------
446
Blastp_CBE
53.17
43%
-60
- C3 -
-
2ZM4
7.0
-
LCK_HUMAN
A:
[14-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
R
E
-------
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
-----
E
V
W
M
G
Y
Y
N
G
---
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
---
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P
-
S
-
G
I
K
-
L
T
-
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
-
E
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
------
449
Blastp_CBE
53.15
43%
-71
- C3 -
-
6PDJ
8.5
-
?
A:
[17-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
R
E
-------
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
-----
E
V
W
M
G
Y
Y
N
G
---
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
---
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P
-
S
-
G
I
K
-
L
T
-
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
-
E
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
------
447
Blastp_CBE
53.11
43%
-62
- C3 -
-
2ZM1
7.1
-
LCK_HUMAN
A:
[14-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
R
E
-------
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
-----
E
V
W
M
G
Y
Y
N
G
---
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
---
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P
-
S
-
G
I
K
-
L
T
-
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
-
E
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
------
153
Blastp_CBE
53.09
58%
-157
- C3 -
-
4PPA
5.5
-
ITK_HUMAN
A:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
---------------
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
473
Blastp_CBE
53.04
43%
-61
- C3 -
-
3BYM
8.6
-
LCK_HUMAN
A:
[9-267]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
R
E
-------
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
-----
E
V
W
M
G
Y
Y
N
G
---
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
---
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P
-
S
-
G
I
K
-
L
T
-
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
-
E
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
------
506
Blastp_CBE
53.03
42%
-58
- C3 -
-
3DQW
5.1
-
SRC_CHICK
D:
[10-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
I
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
-
Q
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
463
Blastp_CBE
52.87
43%
-61
- C3 -
-
1QPC
4.7
-
?
A:
[8-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
R
E
-------
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
-----
E
V
W
M
G
Y
Y
N
G
---
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
---
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P
-
S
-
G
I
K
-
L
T
-
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
-
E
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
------
336
Blastp_CBE
52.85
43%
-61
- C3 -
-
2OF2
7.1
-
LCK_HUMAN
A:
[8-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
R
E
-------
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
-----
E
V
W
M
G
Y
Y
N
G
---
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
---
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P
-
S
-
G
I
K
-
L
T
-
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
-
E
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
------
507
Blastp_CBE
52.74
42%
-58
- C3 -
-
3DQW
5.3
-
SRC_CHICK
C:
[11-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
I
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
-
Q
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
489
Blastp_CBE
52.79
42%
-62
- C3 -
-
1QPD
7.6
-
?
A:
[7-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
V
P
R
E
-------
T
L
K
--------
L
V
E
R
L
G
A
G
Q
A
G
-----
E
V
W
M
G
Y
Y
N
G
---
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
---
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P
-
S
-
G
I
K
-
L
T
-
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
A
E
Y
T
--
A
R
-
E
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
------
476
Blastp_CBE
52.74
35%
-45
- C3 -
-
3CD3
8.4
-
A:
[1-365]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
I
P
E
V
Q
K
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
-
E
L
L
-
V
-
H
-
S
-
G
-
D
---
F
L
V
R
E
S
-----
Q
E
Y
V
L
S
V
--------------
P
R
H
F
I
I
------
N
L
Y
R
L
----
F
P
S
I
P
L
L
I
D
H
-------
L
L
S
T
-
Q
Q
--
P
L
---
S
G
V
V
L
H
R
A
--------
V
---------------
P
---------------
K
-
D
K
W
V
L
N
H
E
-------
D
L
V
--------
L
G
E
Q
I
G
R
G
N
F
G
-----
E
V
F
S
G
R
L
R
A
---
D
---
N
-
T
L
V
A
V
K
S
C
R
-------------
P
D
LKA
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
-
Q
P
-
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
-
T
E
-
G
-
A
-
R
-
L
R
-
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
A
A
--
S
G
-
G
-
L
-
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
-
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
------------
435
Blastp_CBE
52.70
43%
-59
- C3 -
-
3AD5
6.2
-
LCK_HUMAN
A:
[14-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
R
E
-------
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
-----
E
V
W
M
G
Y
Y
N
G
---
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
---
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P
-
S
-
G
I
K
-
L
T
-
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
-
E
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
------
441
Blastp_CBE
52.67
43%
-61
- C3 -
-
3AC4
5.2
-
LCK_HUMAN
A:
[14-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
R
E
-------
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
-----
E
V
W
M
G
Y
Y
N
G
---
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
---
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P
-
S
-
G
I
K
-
L
T
-
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
-
E
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
------
434
Blastp_CBE
52.66
43%
-59
- C3 -
-
3AD6
5.2
-
LCK_HUMAN
A:
[14-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
R
E
-------
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
-----
E
V
W
M
G
Y
Y
N
G
---
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
---
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P
-
S
-
G
I
K
-
L
T
-
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
-
E
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
------
442
Blastp_CBE
52.65
43%
-61
- C3 -
-
3AC3
5.7
-
LCK_HUMAN
A:
[14-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
R
E
-------
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
-----
E
V
W
M
G
Y
Y
N
G
---
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
---
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P
-
S
-
G
I
K
-
L
T
-
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
-
E
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
------
445
Blastp_CBE
52.64
43%
-63
- C3 -
-
2ZYB
7.4
-
LCK_HUMAN
A:
[14-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
R
E
-------
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
-----
E
V
W
M
G
Y
Y
N
G
---
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
---
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P
-
S
-
G
I
K
-
L
T
-
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
-
E
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
------
146
Blastp_CBE
52.59
58%
-149
- C3 -
-
4QD6
5.1
-
B:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
--------------
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
---------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
448
Blastp_CBE
52.57
43%
-55
- C3 -
-
3KXZ
8.6
-
LCK_HUMAN
A:
[16-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
R
E
-------
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
-----
E
V
W
M
G
Y
Y
N
G
---
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
---
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P
-
S
-
G
I
K
-
L
T
-
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
-
E
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
------
509
Blastp_CBE
52.51
42%
-60
- C3 -
-
3DQW
4.8
-
SRC_CHICK
A:
[8-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------------
A
---------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
I
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
-
Q
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
152
Blastp_CBE
52.47
58%
-154
- C3 -
-
4PPA
5.9
-
B:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
---------------
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
508
Blastp_CBE
52.46
42%
-58
- C3 -
-
3DQW
4.2
-
SRC_CHICK
B:
[8-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------------
A
---------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
I
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
-
Q
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
462
Blastp_CBE
52.25
43%
-61
- C3 -
-
1QPE
6.3
-
LCK_HUMAN
A:
[8-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
R
E
-------
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
-----
E
V
W
M
G
Y
Y
N
G
---
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
---
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P
-
S
-
G
I
K
-
L
T
-
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
-
E
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
------
157
Blastp_CBE
52.11
58%
-152
- C3 -
-
4MF0
4.0
-
ITK_HUMAN
A:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
---
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
------
M
---
S
---
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
---------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
560
HHSearch
51.95
32%
-1
- C3 -
-
4FL3
6.2
-
KSYK_HUMAN
A:
[161-632]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
H
E
K
M
P
W
F
H
G
K
I
S
R
E
E
S
E
-
Q
I
V
-
L
I
G
-
S
-
K
-
T
N
G
K
F
L
I
R
A
R
-
D
N
-
N
G
S
Y
A
L
C
L
--
L
H
E
------
G
K
-
V
L
H
Y
R
I
D
K
D
K
T
G
K
L
S
I
P
E
G
K
K
F
D
T
L
W
Q
L
V
E
H
Y
S
Y
K
A
D
G
L
L
R
V
L
T
V
--
P
C
Q
K
------------------REALPMDTEVFESP-
F
---------------
A
-
D
P
E
E
I
R
P
K
-------
E
V
Y
LDRKLLTL
E
D
K
E
L
G
S
G
N
F
G
-----
T
V
K
K
G
Y
Y
Q
M
---
K
KVV
K
-
T
-
V
A
V
K
I
L
K
N
E
A
--
N
DPA
L
---
K
D
---
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
--
E
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
-
Q
N
---
R
-
H
-
V
K
-
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
----------------
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
--
149
Blastp_CBE
51.94
58%
-159
- C3 -
-
4PPC
5.5
-
ITK_HUMAN
A:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
G
--
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
---------------------
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
504
Blastp_CBE
51.91
42%
-64
- C3 -
-
5ZJ6
9.5
-
HCK_HUMAN
A:
[20-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
-------
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
-----
E
V
W
M
A
T
Y
N
K
---
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
---
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
D
-
E
-
G
-
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
Y
T
--
A
R
-
E
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
------
502
Blastp_CBE
51.48
42%
-57
- C3 -
-
2HK5
9.3
-
HCK_HUMAN
A:
[9-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
-------
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
-----
E
V
W
M
A
T
Y
N
K
---
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
---
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
D
-
E
-
G
-
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
Y
T
--
A
R
-
E
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
------
222
Blastp_CBE
51.56
49%
-67
- C3 -
-
3CS9
11.4
-
ABL1_HUMAN
D:
[10-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
-----------
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
558
HHSearch
51.53
33%
-6
- C3 -
-
2OZO
5.9
-
ZAP70_HUMAN
A:
[156-599]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
H
E
R
M
P
W
Y
H
S
S
L
T
R
E
E
A
E
-
R
K
L
-
Y
-
S
-
G
A
Q
-
T
D
G
K
F
L
L
R
P
R
-
K
E
-
Q
G
T
Y
A
L
S
L
--
I
Y
G
------
K
T
-
V
Y
H
Y
L
I
S
Q
D
K
A
G
K
Y
C
I
P
E
G
T
K
F
D
T
L
W
Q
L
V
E
Y
L
K
L
K
A
D
G
L
I
Y
C
L
K
E
--
A
C
P
N
-----------------
M
DTSVFESPFSDPEEL
K
---------------
D
K
K
L
F
L
K
R
D
N
-------
L
L
I
--------
A
D
I
E
L
G
C
G
N
F
G
-----
S
V
R
Q
G
V
Y
R
M
RKK
Q
---
I
-
D
-
V
A
I
K
V
L
K
Q
G
T
--
E
KA-
D
---
T
E
---
E
M
M
R
E
A
Q
I
M
H
Q
L
D
N
P
Y
I
V
R
L
I
G
V
C
Q
A
--
E
A
-
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
-
G
K
-
R
-
E
-
E
-
I
P
-
V
S
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
N
L
A
A
R
N
V
L
L
V
N
R
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
G
-----------------
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
Q
K
P
Y
K
K
M
K
-
G
P
E
V
M
A
F
I
E
Q
G
K
R
M
E
C
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
Y
S
--
505
Blastp_CBE
51.50
42%
-55
- C3 -
-
2DQ7
8.4
-
FYN_HUMAN
X:
[4-262]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
R
E
-------
S
L
Q
--------
L
I
K
R
L
G
N
G
Q
F
G
-----
E
V
W
M
G
T
W
N
G
---
N
---
T
-
K
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
S
F
L
E
E
A
Q
I
M
K
K
L
K
H
D
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
-
D
G
-
E
-
G
-
R
A
L
K
-
L
P
N
L
V
D
M
A
A
Q
V
A
A
G
M
A
Y
I
E
R
M
N
Y
I
H
R
D
L
R
S
A
N
I
L
V
G
N
G
L
I
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
-
Q
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
V
T
K
G
R
V
P
Y
P
G
M
N
-
N
R
E
V
L
E
Q
V
E
R
G
Y
R
M
P
C
P
Q
D
C
P
I
S
L
H
E
L
M
I
H
C
W
K
K
D
P
E
E
R
P
T
F
E
Y
L
Q
S
F
L
E
D
------
503
Blastp_CBE
51.49
42%
-64
- C3 -
-
5ZJ6
9.0
-
HCK_HUMAN
B:
[20-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
-------
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
-----
E
V
W
M
A
T
Y
N
K
---
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
---
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
-
S
D
-
E
-
G
-
S
-
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
Y
T
--
A
R
-
E
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
------
151
Blastp_CBE
51.48
58%
-151
- C3 -
-
4PPB
5.6
-
ITK_HUMAN
A:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
---------------
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
150
Blastp_CBE
51.48
58%
-149
- C3 -
-
4PPB
5.9
-
B:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
---------------
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
156
Blastp_CBE
51.18
58%
-152
- C3 -
-
4MF0
4.5
-
B:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
---
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
------
M
---
S
---
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
148
Blastp_CBE
50.85
58%
-156
- C3 -
-
4PPC
5.3
-
B:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
-------
E
L
T
--------
F
V
Q
E
I
G
S
G
--
G
-----
L
V
H
L
G
Y
W
L
N
---
K
---
D
-
K
-
V
A
I
K
T
I
---------------------
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
---
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
-
T
Q
-
R
-
G
-
L
-
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
331
Blastp_CBE
50.25
43%
-65
- C3 -
-
3B2W
11.2
-
LCK_HUMAN
A:
[13-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
R
E
-------
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
-----
E
V
W
M
G
Y
Y
N
G
---
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
---
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P
-
S
-
G
I
K
-
L
T
-
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
----
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
------
358
Blastp_CBE
49.78
43%
-65
- C3 -
-
2ZVA
7.8
-
LYN_MOUSE
A:
[6-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
-------
S
I
K
--------
L
V
K
K
L
G
A
G
Q
F
G
-----
E
V
W
M
G
Y
Y
N
N
---
S
---
T
-
K
-
V
A
V
K
T
L
K
P
G
T
--
M
---
S
---
V
Q
---
A
F
L
E
E
A
N
L
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
V
V
T
K
E
-
E
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-
G
-
G
-
K
-
V
L
-
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
I
E
----
T
--
A
R
-
E
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
N
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
T
-
N
A
D
V
M
S
A
L
S
Q
G
Y
R
M
P
R
M
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
------
375
Blastp_CBE
49.32
43%
-74
- C3 -
-
3F3W
11.0
-
SRC_CHICK
B:
[11-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
288
Blastp_CBE
48.93
49%
-23
- C3 -
-
2QOH
8.1
-
ABL1_MOUSE
A:
[5-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
--------
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
301
Blastp_CBE
48.90
48%
-27
- C3 -
-
2Z60
8.5
-
ABL1_MOUSE
A:
[5-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
--------
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
347
Blastp_CBE
48.75
43%
-72
- C3 -
-
3F3V
10.5
-
SRC_CHICK
B:
[9-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
---------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
423
Blastp_CBE
48.69
43%
-64
- C3 -
-
2OIQ
10.4
-
SRC_CHICK
A:
[9-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
---------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
316
Blastp_CBE
48.63
48%
-20
- C3 -
-
3HMI
6.6
-
A:
[27-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
V
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
-
P
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
E
-
E
-
V
T
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
---------------
287
Blastp_CBE
48.45
49%
-20
- C3 -
-
2QOH
8.5
-
ABL1_MOUSE
B:
[5-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
-----
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
406
Blastp_CBE
48.40
43%
-61
- C3 -
-
3G6G
12.4
-
SRC_CHICK
A:
[9-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
---------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
------------------
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
277
Blastp_CBE
48.45
49%
-21
- C3 -
-
1M52
10.2
-
ABL1_MOUSE
B:
[10-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
326
Blastp_CBE
48.40
43%
-72
- C3 -
-
2OG8
10.5
-
LCK_HUMAN
A:
[3-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
R
E
-------
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
-----
E
V
W
M
G
Y
Y
N
G
---
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
---
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P
-
S
-
G
I
K
-
L
T
-
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
----------------------
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
------
308
Blastp_CBE
48.42
48%
-25
- C3 -
-
4TWP
7.8
-
ABL1_HUMAN
B:
[3-254]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
238
Blastp_CBE
48.41
49%
-23
- C3 -
-
2F4J
7.6
-
ABL1_HUMAN
A:
[6-260]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
P
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
320
Blastp_CBE
48.40
48%
-32
- C3 -
-
2XYN
7.6
-
ABL2_HUMAN
A:
[27-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
V
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
--
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
-
P
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
E
-
E
-
V
T
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
---------------
388
Blastp_CBE
48.37
43%
-62
- C3 -
-
4YBK
9.0
-
SRC_CHICK
A:
[9-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
---------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
-----------------
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
286
Blastp_CBE
48.36
49%
-25
- C3 -
-
3KF4
9.5
-
ABL1_MOUSE
A:
[5-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
-------------
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
257
Blastp_CBE
48.30
49%
-19
- C3 -
-
2G2H
9.9
-
ABL1_HUMAN
B:
[8-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
P
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
290
Blastp_CBE
48.27
49%
-22
- C3 -
-
6NPV
11.5
-
ABL1_HUMAN
A:
[18-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
-------------
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
360
Blastp_CBE
48.22
43%
-65
- C3 -
-
2ZV8
3.9
-
LYN_MOUSE
A:
[6-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
-------
S
I
K
--------
L
V
K
K
L
G
A
G
Q
F
G
-----
E
V
W
M
G
Y
Y
N
N
---
S
---
T
-
K
-
V
A
V
K
T
L
K
P
G
T
--
M
---
S
---
V
Q
---
A
F
L
E
E
A
N
L
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
V
V
T
K
E
-
E
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-
G
-
G
-
K
-
V
L
-
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
I
---------
R
-
E
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
N
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
T
-
N
A
D
V
M
S
A
L
S
Q
G
Y
R
M
P
R
M
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
------
278
Blastp_CBE
48.26
49%
-17
- C3 -
-
1M52
10.4
-
ABL1_MOUSE
A:
[10-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
341
Blastp_CBE
48.19
43%
-68
- C3 -
-
3TZ8
12.0
-
SRC_CHICK
B:
[9-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
---------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
--------------------
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
338
Blastp_CBE
48.19
43%
-58
- C3 -
-
3MPM
7.2
-
LCK_HUMAN
A:
[4-262]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
R
E
-------
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
-----
E
V
W
M
G
Y
Y
N
G
---
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
---
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P
-
S
-
G
I
K
-
L
T
-
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
N
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
-------
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
------
321
Blastp_CBE
48.22
48%
-23
- C3 -
-
2V7A
7.7
-
ABL1_HUMAN
B:
[8-260]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
393
Blastp_CBE
48.16
43%
-65
- C3 -
-
4O2P
8.1
-
SRC_CHICK
B:
[9-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
---------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
-
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
-----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
413
Blastp_CBE
48.14
43%
-64
- C3 -
-
3EN5
6.5
-
SRC_CHICK
B:
[9-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
---------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
294
Blastp_CBE
48.19
49%
-20
- C3 -
-
6NPE
11.1
-
ABL1_HUMAN
A:
[18-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
-------------
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
404
Blastp_CBE
48.11
43%
-66
- C3 -
-
3UQF
7.0
-
SRC_CHICK
A:
[11-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
---------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
376
Blastp_CBE
48.11
43%
-74
- C3 -
-
3F3W
10.4
-
SRC_CHICK
A:
[10-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
318
Blastp_CBE
48.16
48%
-32
- C3 -
-
2XYN
5.8
-
C:
[27-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
V
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
--
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
-
P
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
E
-
E
-
V
T
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
---------------
359
Blastp_CBE
48.11
43%
-61
- C3 -
-
2ZV9
5.7
-
LYN_MOUSE
A:
[6-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
-------
S
I
K
--------
L
V
K
K
L
G
A
G
Q
F
G
-----
E
V
W
M
G
Y
Y
N
N
---
S
---
T
-
K
-
V
A
V
K
T
L
K
P
G
T
--
M
---
S
---
V
Q
---
A
F
L
E
E
A
N
L
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
V
V
T
K
E
-
E
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-
G
-
G
-
K
-
V
L
-
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
I
-----------
E
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
N
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
T
-
N
A
D
V
M
S
A
L
S
Q
G
Y
R
M
P
R
M
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
------
311
Blastp_CBE
48.11
48%
-21
- C3 -
-
2GQG
7.7
-
ABL1_HUMAN
A:
[10-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
329
Blastp_CBE
48.14
43%
-70
- C3 -
-
3BYU
11.0
-
LCK_HUMAN
A:
[14-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
R
E
-------
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
-----
E
V
W
M
G
Y
Y
N
G
---
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
---
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P
-
S
-
G
I
K
-
L
T
-
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
--------------------
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
------
330
Blastp_CBE
48.13
43%
-73
- C3 -
-
3BYS
11.3
-
LCK_HUMAN
A:
[14-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
R
E
-------
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
-----
E
V
W
M
G
Y
Y
N
G
---
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
---
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P
-
S
-
G
I
K
-
L
T
-
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
----------------------
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
------
285
Blastp_CBE
48.11
49%
-24
- C3 -
-
3KF4
9.4
-
ABL1_MOUSE
B:
[5-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
---
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
344
Blastp_CBE
48.09
43%
-71
- C3 -
-
3TZ7
8.9
-
SRC_CHICK
A:
[10-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
421
Blastp_CBE
48.04
43%
-71
- C3 -
-
3D7T
8.4
-
SRC_CHICK
B:
[11-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
----------------
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
381
Blastp_CBE
48.03
43%
-63
- C3 -
-
5XP7
4.8
-
SRC_CHICK
A:
[10-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
-----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
398
Blastp_CBE
47.94
43%
-65
- C3 -
-
4DGG
8.8
-
SRC_CHICK
A:
[9-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
---------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
361
Blastp_CBE
47.94
43%
-61
- C3 -
-
3GEQ
6.4
-
SRC_CHICK
B:
[5-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
G
-------
L
---------------
A
---------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
A
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
432
Blastp_CBE
47.89
42%
-67
- C3 -
-
3OEZ
8.8
-
SRC_CHICK
A:
[10-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
226
Blastp_CBE
47.94
49%
-25
- C3 -
-
2HZI
10.7
-
ABL1_HUMAN
B:
[10-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
------
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
342
Blastp_CBE
47.93
43%
-68
- C3 -
-
3TZ8
11.0
-
SRC_CHICK
A:
[10-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
380
Blastp_CBE
47.89
43%
-59
- C3 -
-
5XP7
6.7
-
SRC_CHICK
B:
[9-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
---------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
296
Blastp_CBE
47.86
49%
-19
- C3 -
-
3PYY
11.7
-
ABL1_HUMAN
A:
[18-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
---------
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
431
Blastp_CBE
47.79
42%
-64
- C3 -
-
3OEZ
9.0
-
SRC_CHICK
B:
[9-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
---------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
351
Blastp_CBE
47.82
43%
-70
- C3 -
-
3F3T
7.1
-
SRC_CHICK
A:
[10-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
292
Blastp_CBE
47.86
49%
-18
- C3 -
-
6NPU
11.4
-
ABL1_HUMAN
A:
[18-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
-------------
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
260
Blastp_CBE
47.84
49%
-14
- C3 -
-
2G2F
4.2
-
ABL1_HUMAN
A:
[7-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
P
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
420
Blastp_CBE
47.83
43%
-60
- C3 -
-
3DQX
4.4
-
SRC_CHICK
A:
[12-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
------------
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
248
Blastp_CBE
47.82
49%
-20
- C3 -
-
3UE4
6.9
-
ABL1_HUMAN
A:
[8-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
383
Blastp_CBE
47.74
43%
-55
- C3 -
-
5XP5
4.1
-
SRC_CHICK
A:
[12-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
------------
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
348
Blastp_CBE
47.79
43%
-72
- C3 -
-
3F3V
10.5
-
SRC_CHICK
A:
[10-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
322
Blastp_CBE
47.75
48%
-22
- C3 -
-
2V7A
7.6
-
ABL1_HUMAN
A:
[7-260]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
482
Blastp_CBE
47.78
42%
-59
- C3 -
-
2BDJ
9.9
-
SRC_HUMAN
A:
[3-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
325
Blastp_CBE
47.72
43%
-68
- C3 -
-
2OG8
10.4
-
?
B:
[3-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
R
E
-------
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
-----
E
V
W
M
G
Y
Y
N
G
---
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
---
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P
-
S
-
G
I
K
-
L
T
-
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
---------------------
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
------
234
Blastp_CBE
47.75
49%
-13
- C3 -
-
2HYY
11.2
-
ABL1_HUMAN
B:
[6-259]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
-
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
227
Blastp_CBE
47.74
49%
-17
- C3 -
-
2HZI
10.7
-
ABL1_HUMAN
A:
[10-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
419
Blastp_CBE
47.66
43%
-55
- C3 -
-
3DQX
4.4
-
SRC_CHICK
B:
[12-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
----------
Q
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
409
Blastp_CBE
47.73
43%
-60
- C3 -
-
3F6X
7.0
-
SRC_CHICK
B:
[8-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------------
A
---------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
-
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
----------------
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
337
Blastp_CBE
47.69
43%
-57
- C3 -
-
4C3F
7.5
-
LCK_HUMAN
A:
[4-262]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
R
E
-------
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
-----
E
V
W
M
G
Y
Y
N
G
---
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
---
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P
-
S
-
G
I
K
-
L
T
-
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
N
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
--
A
R
-------
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
------
237
Blastp_CBE
47.72
49%
-23
- C3 -
-
2HZ0
10.3
-
ABL1_HUMAN
A:
[6-259]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
251
Blastp_CBE
47.70
49%
-9
- C3 -
-
2G1T
7.1
-
ABL1_HUMAN
B:
[7-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
350
Blastp_CBE
47.65
43%
-72
- C3 -
-
3F3U
6.1
-
SRC_CHICK
A:
[10-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
252
Blastp_CBE
47.69
49%
-9
- C3 -
-
2G1T
7.3
-
ABL1_HUMAN
A:
[7-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
241
Blastp_CBE
47.67
49%
-21
- C3 -
-
4WA9
9.0
-
ABL1_HUMAN
B:
[7-260]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
362
Blastp_CBE
47.61
43%
-58
- C3 -
-
3GEQ
6.7
-
SRC_CHICK
A:
[5-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
G
-------
L
---------------
A
---------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
A
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
-------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
319
Blastp_CBE
47.65
48%
-30
- C3 -
-
2XYN
7.5
-
ABL2_HUMAN
B:
[27-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
V
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
--
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
-
P
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
E
-
E
-
V
T
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
---------------
328
Blastp_CBE
47.64
43%
-68
- C3 -
-
5XY1
5.9
-
LYN_HUMAN
A:
[6-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
-------
S
I
K
--------
L
V
K
R
L
G
A
G
Q
F
G
-----
E
V
W
M
G
Y
Y
N
N
---
S
---
T
-
K
-
V
A
V
K
T
L
K
P
G
T
--
M
---
S
---
V
Q
---
A
F
L
E
E
A
N
L
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
V
V
T
R
E
-
E
P
-
I
Y
I
I
T
E
Y
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-
G
-
G
-
K
-
V
L
-
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
-----------------
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
D
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
T
-
N
A
D
V
M
T
A
L
S
Q
G
Y
R
M
P
R
V
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
------
258
Blastp_CBE
47.61
49%
-15
- C3 -
-
2G2H
9.4
-
ABL1_HUMAN
A:
[8-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
P
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
483
Blastp_CBE
47.58
42%
-58
- C3 -
-
2BDF
7.1
-
SRC_HUMAN
B:
[1-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------------
A
---------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
--------------
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
427
Blastp_CBE
47.47
42%
-62
- C3 -
-
3QLG
8.2
-
SRC_CHICK
B:
[9-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
---------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
-----
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
410
Blastp_CBE
47.54
43%
-62
- C3 -
-
3F6X
7.7
-
SRC_CHICK
A:
[8-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------------
A
---------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
----------
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
---------------
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
394
Blastp_CBE
47.40
43%
-64
- C3 -
-
4O2P
8.3
-
SRC_CHICK
A:
[10-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
----
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
---------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
384
Blastp_CBE
47.52
43%
-66
- C3 -
-
5K9I
7.0
-
SRC_CHICK
B:
[12-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
407
Blastp_CBE
47.51
43%
-60
- C3 -
-
3F6X
7.1
-
SRC_CHICK
D:
[10-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
---------------
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
415
Blastp_CBE
47.40
43%
-57
- C3 -
-
3EN4
6.6
-
SRC_CHICK
B:
[10-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
----------------
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
428
Blastp_CBE
47.39
42%
-62
- C3 -
-
3QLG
8.1
-
SRC_CHICK
A:
[11-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
480
Blastp_CBE
47.38
42%
-66
- C3 -
-
1YOM
7.0
-
SRC_HUMAN
B:
[5-268]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------------
A
---------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
G
E
T
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
368
Blastp_CBE
47.46
43%
-71
- C3 -
-
5D12
5.6
-
SRC_CHICK
A:
[10-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
----------
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
-----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
313
Blastp_CBE
47.40
48%
-24
- C3 -
-
4XLI
8.1
-
ABL2_MOUSE
A:
[3-254]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
V
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
---------
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
-
P
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
-
E
C
S
R
-
E
-
E
-
V
T
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
---------------
310
Blastp_CBE
47.41
48%
-20
- C3 -
-
2GQG
8.2
-
ABL1_HUMAN
B:
[10-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
273
Blastp_CBE
47.38
49%
-14
- C3 -
-
3K5V
11.3
-
ABL1_MOUSE
A:
[10-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
---
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
307
Blastp_CBE
47.40
48%
-20
- C3 -
-
3DK3
8.2
-
ABL1_MOUSE
A:
[6-257]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
---------
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
F
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
276
Blastp_CBE
47.39
49%
-15
- C3 -
-
1OPJ
11.1
-
ABL1_MOUSE
A:
[10-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
250
Blastp_CBE
47.38
49%
-5
- C3 -
-
2G1T
7.5
-
ABL1_HUMAN
C:
[7-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
303
Blastp_CBE
47.36
48%
-17
- C3 -
-
3OY3
11.7
-
ABL1_MOUSE
A:
[5-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
478
Blastp_CBE
47.27
43%
-68
- C3 -
-
3U51
8.4
-
SRC_CHICK
A:
[3-260]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
453
Blastp_CBE
47.27
42%
-71
- C3 -
-
5T0P
6.9
-
SRC_CHICK
A:
[10-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
C
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
297
Blastp_CBE
47.34
48%
-19
- C3 -
-
3QRJ
9.9
-
ABL1_HUMAN
B:
[11-264]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
324
Blastp_CBE
47.33
48%
-20
- C3 -
-
3DK7
8.2
-
ABL1_MOUSE
A:
[6-257]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
---------
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
385
Blastp_CBE
47.30
43%
-61
- C3 -
-
5K9I
6.1
-
SRC_CHICK
A:
[12-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
366
Blastp_CBE
47.24
43%
-63
- C3 -
-
6HVE
5.2
-
?
A:
[9-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
---------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
259
Blastp_CBE
47.29
49%
-11
- C3 -
-
2G2F
3.6
-
ABL1_HUMAN
B:
[9-261]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
-----
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
P
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
340
Blastp_CBE
47.28
43%
-69
- C3 -
-
3TZ9
9.9
-
SRC_CHICK
A:
[10-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
299
Blastp_CBE
47.25
48%
-22
- C3 -
-
3IK3
12.3
-
ABL1_MOUSE
B:
[5-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
240
Blastp_CBE
47.27
49%
-16
- C3 -
-
4ZOG
7.7
-
ABL1_HUMAN
A:
[5-258]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
221
Blastp_CBE
47.25
49%
-16
- C3 -
-
3QRI
10.8
-
ABL1_HUMAN
A:
[10-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
306
Blastp_CBE
47.21
48%
-26
- C3 -
-
3DK3
8.5
-
ABL1_MOUSE
B:
[6-257]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
------
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
F
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
275
Blastp_CBE
47.24
49%
-17
- C3 -
-
1OPJ
11.3
-
ABL1_MOUSE
B:
[10-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
270
Blastp_CBE
47.21
49%
-16
- C3 -
-
3MS9
11.6
-
ABL1_MOUSE
B:
[10-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
---
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
265
Blastp_CBE
47.21
49%
-13
- C3 -
-
6HD4
11.5
-
ABL1_MOUSE
A:
[10-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
---
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
468
Blastp_CBE
47.19
42%
-69
- C3 -
-
3G6H
11.5
-
SRC_CHICK
B:
[11-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
I
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
387
Blastp_CBE
47.18
43%
-64
- C3 -
-
5J5S
9.5
-
SRC_CHICK
A:
[11-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
392
Blastp_CBE
47.16
43%
-58
- C3 -
-
4U5J
5.9
-
SRC_CHICK
A:
[12-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
------------
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
302
Blastp_CBE
47.14
48%
-21
- C3 -
-
3OY3
11.5
-
ABL1_MOUSE
B:
[5-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
402
Blastp_CBE
47.06
43%
-63
- C3 -
-
3UQG
4.1
-
SRC_CHICK
A:
[11-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
397
Blastp_CBE
47.10
43%
-67
- C3 -
-
4DGG
9.9
-
SRC_CHICK
B:
[9-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
---------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
-----------------
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
339
Blastp_CBE
47.02
43%
-71
- C3 -
-
3TZ9
7.0
-
SRC_CHICK
B:
[10-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
254
Blastp_CBE
47.05
49%
-12
- C3 -
-
2HIW
9.5
-
ABL1_HUMAN
A:
[7-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
219
Blastp_CBE
47.04
49%
-15
- C3 -
-
3QRK
8.7
-
ABL1_HUMAN
A:
[10-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
279
Blastp_CBE
47.03
49%
-18
- C3 -
-
1IEP
11.4
-
ABL1_MOUSE
B:
[10-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
382
Blastp_CBE
46.97
43%
-58
- C3 -
-
5XP5
4.6
-
SRC_CHICK
B:
[12-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
------------
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
334
Blastp_CBE
47.02
43%
-68
- C3 -
-
3A4O
8.1
-
LYN_HUMAN
X:
[7-267]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
-------
S
I
K
--------
L
V
K
R
L
G
A
G
Q
F
G
-----
E
V
W
M
G
Y
Y
N
N
---
S
---
T
-
K
-
V
A
V
K
T
L
K
P
G
T
--
M
---
S
---
V
Q
---
A
F
L
E
E
A
N
L
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
V
V
T
R
E
-
E
P
-
I
Y
I
I
T
E
Y
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-
G
-
G
-
K
-
V
L
-
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
------------
E
-
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
D
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
T
-
N
A
D
V
M
T
A
L
S
Q
G
Y
R
M
P
R
V
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
------
370
Blastp_CBE
46.96
43%
-68
- C3 -
-
5D11
5.5
-
SRC_CHICK
A:
[11-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
------------
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
369
Blastp_CBE
46.96
43%
-68
- C3 -
-
5D11
5.0
-
SRC_CHICK
B:
[10-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
--------------------
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
256
Blastp_CBE
46.99
49%
-18
- C3 -
-
2G2I
4.2
-
ABL1_HUMAN
A:
[7-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
---
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
P
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
459
Blastp_CBE
46.92
42%
-62
- C3 -
-
4MXO
7.4
-
SRC_HUMAN
B:
[11-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
-----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
345
Blastp_CBE
46.95
43%
-62
- C3 -
-
3G5D
7.6
-
SRC_CHICK
B:
[11-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
---
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
-----
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
230
Blastp_CBE
46.99
49%
-13
- C3 -
-
2HZ4
8.3
-
ABL1_HUMAN
B:
[6-259]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
-----
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
346
Blastp_CBE
46.94
43%
-60
- C3 -
-
3G5D
8.1
-
SRC_CHICK
A:
[10-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
---
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
----------
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
232
Blastp_CBE
46.98
49%
-15
- C3 -
-
2HYY
11.2
-
ABL1_HUMAN
D:
[6-259]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
----
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
235
Blastp_CBE
46.97
49%
-16
- C3 -
-
2HYY
11.3
-
ABL1_HUMAN
A:
[8-259]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
-
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
309
Blastp_CBE
46.96
48%
-20
- C3 -
-
4TWP
7.5
-
ABL1_HUMAN
A:
[3-254]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
----------
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
323
Blastp_CBE
46.95
48%
-26
- C3 -
-
3DK7
7.8
-
ABL1_MOUSE
B:
[6-257]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
------
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
484
Blastp_CBE
46.86
42%
-61
- C3 -
-
2BDF
6.9
-
SRC_HUMAN
A:
[3-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
460
Blastp_CBE
46.86
42%
-60
- C3 -
-
4MXO
5.4
-
SRC_HUMAN
A:
[10-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
225
Blastp_CBE
46.94
49%
-10
- C3 -
-
3CS9
12.4
-
ABL1_HUMAN
A:
[10-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
---------
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
280
Blastp_CBE
46.92
49%
-17
- C3 -
-
1IEP
11.1
-
ABL1_MOUSE
A:
[10-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
465
Blastp_CBE
46.90
42%
-58
- C3 -
-
4MXX
7.3
-
SRC_HUMAN
A:
[10-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
T
D
F
G
L
A
R
L
I
E
----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
312
Blastp_CBE
46.86
48%
-16
- C3 -
-
4XLI
7.2
-
B:
[3-254]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
----
G
-----
E
V
Y
V
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
-
P
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
-
E
C
S
R
-
E
-
E
-
V
T
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
---------------
452
Blastp_CBE
46.89
42%
-67
- C3 -
-
5T0P
6.9
-
SRC_CHICK
B:
[11-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
C
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
391
Blastp_CBE
46.87
43%
-60
- C3 -
-
4U5J
5.6
-
SRC_CHICK
B:
[12-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
------------
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
249
Blastp_CBE
46.86
49%
-4
- C3 -
-
2G1T
7.2
-
ABL1_HUMAN
D:
[7-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
416
Blastp_CBE
46.75
43%
-66
- C3 -
-
3EN4
6.5
-
SRC_CHICK
A:
[11-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
----
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
487
Blastp_CBE
46.73
41%
-66
- C3 -
-
4MXY
6.8
-
SRC_HUMAN
B:
[11-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
L
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
-----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
247
Blastp_CBE
46.80
49%
-17
- C3 -
-
3UE4
7.7
-
ABL1_HUMAN
B:
[8-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
--
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
405
Blastp_CBE
46.77
43%
-59
- C3 -
-
3G6G
12.9
-
SRC_CHICK
B:
[9-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
---------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
-------------------
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
389
Blastp_CBE
46.71
43%
-66
- C3 -
-
4YBJ
5.2
-
SRC_CHICK
B:
[12-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
-----
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
220
Blastp_CBE
46.76
49%
-15
- C3 -
-
3QRI
9.5
-
ABL1_HUMAN
B:
[10-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
----------
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
283
Blastp_CBE
46.75
49%
-15
- C3 -
-
3KFA
12.8
-
ABL1_MOUSE
B:
[5-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
343
Blastp_CBE
46.74
43%
-67
- C3 -
-
3TZ7
9.7
-
SRC_CHICK
B:
[10-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
485
Blastp_CBE
46.73
41%
-66
- C3 -
-
4MXZ
6.8
-
SRC_HUMAN
B:
[11-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
L
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
-----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
284
Blastp_CBE
46.69
49%
-13
- C3 -
-
3KFA
12.8
-
ABL1_MOUSE
A:
[5-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
264
Blastp_CBE
46.69
49%
-18
- C3 -
-
6HD4
11.4
-
ABL1_MOUSE
B:
[10-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
-----
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
272
Blastp_CBE
46.71
49%
-15
- C3 -
-
3K5V
11.5
-
ABL1_MOUSE
B:
[10-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
-----
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
262
Blastp_CBE
46.69
49%
-18
- C3 -
-
6HD6
11.6
-
ABL1_MOUSE
B:
[10-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
-----
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
477
Blastp_CBE
46.64
43%
-65
- C3 -
-
3U51
8.8
-
SRC_CHICK
B:
[3-260]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
298
Blastp_CBE
46.61
48%
-21
- C3 -
-
3QRJ
10.4
-
ABL1_HUMAN
A:
[12-264]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
----------
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
255
Blastp_CBE
46.59
49%
-17
- C3 -
-
2G2I
3.6
-
ABL1_HUMAN
B:
[7-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
----
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
P
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
469
Blastp_CBE
46.58
42%
-66
- C3 -
-
3SVV
6.1
-
SRC_CHICK
B:
[9-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
---------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
---
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
-
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
C
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
488
Blastp_CBE
46.49
41%
-64
- C3 -
-
4MXY
5.6
-
SRC_HUMAN
A:
[10-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
L
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
396
Blastp_CBE
46.57
43%
-74
- C3 -
-
4FIC
5.3
-
SRC_CHICK
A:
[8-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------------
A
---------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
---
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
-------------------
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
417
Blastp_CBE
46.55
43%
-67
- C3 -
-
3EL8
8.0
-
SRC_CHICK
A:
[11-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
486
Blastp_CBE
46.49
41%
-64
- C3 -
-
4MXZ
5.6
-
SRC_HUMAN
A:
[10-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
L
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
349
Blastp_CBE
46.48
43%
-66
- C3 -
-
3F3U
6.4
-
SRC_CHICK
B:
[10-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
-------
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
481
Blastp_CBE
46.46
42%
-64
- C3 -
-
1YOM
6.0
-
SRC_HUMAN
A:
[5-268]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------------
A
---------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
G
E
T
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
403
Blastp_CBE
46.42
43%
-63
- C3 -
-
3UQF
7.6
-
SRC_CHICK
B:
[9-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
---------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
---------------
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
470
Blastp_CBE
46.39
42%
-56
- C3 -
-
3SVV
5.7
-
SRC_CHICK
A:
[10-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
-
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
C
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
--------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
400
Blastp_CBE
46.38
43%
-60
- C3 -
-
4AGW
9.7
-
SRC_CHICK
A:
[10-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
282
Blastp_CBE
46.27
49%
-13
- C3 -
-
1FPU
9.1
-
ABL1_MOUSE
A:
[10-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
501
Blastp_CBE
46.25
42%
-62
- C3 -
-
4MCV
5.9
-
SRC_CHICK
A:
[4-263]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
408
Blastp_CBE
46.17
43%
-57
- C3 -
-
3F6X
4.5
-
SRC_CHICK
C:
[8-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------------
A
---------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
------------
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
---------------
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
357
Blastp_CBE
46.23
43%
-72
- C3 -
-
2HWO
4.5
-
SRC_CHICK
A:
[8-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------------
A
---------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
-
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
------------------
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
----
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
245
Blastp_CBE
46.22
49%
-16
- C3 -
-
4YC8
4.2
-
ABL1_HUMAN
B:
[8-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
-----------
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
464
Blastp_CBE
46.19
42%
-59
- C3 -
-
4MXX
7.5
-
SRC_HUMAN
B:
[11-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
T
D
F
G
L
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
305
Blastp_CBE
46.17
48%
-14
- C3 -
-
6BL8
7.4
-
ABL1_HUMAN
A:
[3-254]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
F
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
451
Blastp_CBE
46.16
42%
-59
- C3 -
-
5TEH
4.8
-
SRC_CHICK
A:
[9-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
---------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
C
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
216
Blastp_CBE
46.13
43%
-19
- C3 -
-
4XEY
8.0
-
ABL1_HUMAN
A:
[116-371]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
---------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
----
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
390
Blastp_CBE
46.09
43%
-63
- C3 -
-
4YBJ
10.0
-
SRC_CHICK
A:
[12-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
--
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
429
Blastp_CBE
46.07
42%
-58
- C3 -
-
3QLF
4.5
-
SRC_CHICK
B:
[11-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
----
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
---------------------
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
456
Blastp_CBE
46.03
42%
-57
- C3 -
-
5SWH
6.4
-
SRC_CHICK
B:
[8-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------------
A
---------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
C
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
315
Blastp_CBE
45.92
49%
-20
- C3 -
-
3DK6
7.7
-
ABL1_MOUSE
A:
[6-257]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
--
G
Q
F
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
----------
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
386
Blastp_CBE
45.91
43%
-59
- C3 -
-
5J5S
8.6
-
SRC_CHICK
B:
[9-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
---------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
--
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
450
Blastp_CBE
45.89
42%
-64
- C3 -
-
5TEH
6.7
-
SRC_CHICK
B:
[9-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
---------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
C
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
399
Blastp_CBE
45.87
43%
-57
- C3 -
-
4AGW
10.3
-
SRC_CHICK
B:
[11-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
457
Blastp_CBE
45.81
42%
-57
- C3 -
-
5SWH
6.8
-
SRC_CHICK
A:
[11-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
C
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
500
Blastp_CBE
45.73
42%
-61
- C3 -
-
4MCV
5.5
-
SRC_CHICK
B:
[4-263]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
-
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
----------------
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
367
Blastp_CBE
45.69
43%
-73
- C3 -
-
5D12
6.1
-
SRC_CHICK
B:
[11-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
---------------
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
333
Blastp_CBE
45.57
43%
-67
- C3 -
-
2OFV
10.3
-
LCK_HUMAN
A:
[13-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
R
E
-------
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
-----
E
V
W
M
G
Y
Y
N
G
---
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
------------------
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P
-
S
-
G
I
K
-
L
T
-
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
----------------------
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
------
239
Blastp_CBE
45.56
49%
-22
- C3 -
-
4ZOG
6.0
-
ABL1_HUMAN
B:
[6-258]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
-----
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
401
Blastp_CBE
45.52
43%
-55
- C3 -
-
3UQG
4.2
-
SRC_CHICK
B:
[9-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
---------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
---------
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
---------
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
274
Blastp_CBE
45.47
49%
-14
- C3 -
-
2HZN
7.0
-
ABL1_MOUSE
A:
[10-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
---
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
--
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
374
Blastp_CBE
45.38
43%
-70
- C3 -
-
3LOK
2.2
-
SRC_CHICK
A:
[10-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
---
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
-----------------------
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
-------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
253
Blastp_CBE
45.32
49%
-11
- C3 -
-
2HIW
9.6
-
ABL1_HUMAN
B:
[7-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
246
Blastp_CBE
45.26
49%
-17
- C3 -
-
4YC8
5.6
-
ABL1_HUMAN
A:
[8-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
-----------
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
------
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
378
Blastp_CBE
45.22
43%
-66
- C3 -
-
2QQ7
4.8
-
SRC_CHICK
A:
[10-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
-
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
----------------------
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
-------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
430
Blastp_CBE
45.18
42%
-73
- C3 -
-
3QLF
7.8
-
SRC_CHICK
A:
[11-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
--------------------
L
Q
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
455
Blastp_CBE
45.02
42%
-61
- C3 -
-
5SYS
10.0
-
SRC_CHICK
A:
[11-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
C
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
218
Blastp_CBE
45.06
52%
-41
- C3 -
-
4CSV
10.6
-
?
A:
[6-257]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
R
S
-------
E
I
T
--------
L
E
R
K
L
G
S
G
Q
F
G
-----
E
V
Y
E
G
K
W
R
N
Y--
N
---
I
-
E
-
V
A
V
K
T
L
K
E
G
T
--
M
---
S
---
V
E
---
E
F
L
Q
E
A
Q
I
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
T
K
E
-
P
P
-
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
-
D
C
-------
V
N
-
A
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
V
K
V
A
D
F
G
----------------------
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
-
G
S
E
V
I
E
Q
V
E
R
G
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
---------------
353
Blastp_CBE
45.02
43%
-71
- C3 -
-
2QLQ
6.1
-
SRC_CHICK
A:
[9-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
---------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
------------------------
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
418
Blastp_CBE
44.70
43%
-60
- C3 -
-
3EL7
9.7
-
SRC_CHICK
A:
[10-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
--
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
-
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-----
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
365
Blastp_CBE
44.70
43%
-66
- C3 -
-
6HVE
4.9
-
?
B:
[11-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
----------------------
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
355
Blastp_CBE
44.72
43%
-73
- C3 -
-
2HWP
3.2
-
SRC_CHICK
A:
[9-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
---------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
----------
V
K
L
G
Q
G
C
-
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
---------------------
F
L
Q
-
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
314
Blastp_CBE
44.70
49%
-16
- C3 -
-
3DK6
4.0
-
ABL1_MOUSE
B:
[6-257]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
------------
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
----------
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
526
Fugue
44.53
45%
-47
- C3 -
-
1BYG
7.5
-
CSK_HUMAN
A:
[15-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
W
A
L
N
M
K
-------
E
L
K
--------
L
L
Q
T
I
G
K
G
E
F
G
-----
D
V
M
L
G
D
Y
R
G
-------
N
-
K
-
V
A
V
K
C
I
K
-----
N
---
D
---
A
Q
---
A
F
L
A
E
A
S
V
M
T
Q
L
R
H
S
N
L
V
Q
L
L
G
V
I
V
--E
E
G
-
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
-
S
R
-
G
R
S
-
V
-
L
G
-
G
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
E
D
N
V
A
K
V
S
D
F
G
---------------------
L
L
P
V
K
W
T
A
P
E
A
L
R
E
K
K
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
R
V
P
Y
P
R
I
P
L-
K
D
V
V
P
R
V
E
K
G
Y
K
M
D
A
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
Q
L
E
H
I
K
T
H
E
L
332
Blastp_CBE
44.49
43%
-67
- C3 -
-
2OFV
10.4
-
?
B:
[13-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
R
E
-------
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
-----
E
V
W
M
G
Y
Y
N
G
---
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
----------------
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
-
T
P
-
S
-
G
I
K
-
L
T
-
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
----------------
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
--------
I
Q
N
L
E
-
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
------
454
Blastp_CBE
44.47
42%
-59
- C3 -
-
5SYS
10.3
-
SRC_CHICK
B:
[11-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
C
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
395
Blastp_CBE
44.39
43%
-66
- C3 -
-
4FIC
5.2
-
SRC_CHICK
B:
[11-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
-------------------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
475
Blastp_CBE
44.40
42%
-56
- C3 -
-
1YOL
4.4
-
SRC_HUMAN
A:
[6-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
---------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
--
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
G
E
T
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
-------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
317
Blastp_CBE
44.39
48%
-12
- C3 -
-
3GVU
11.6
-
A:
[27-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
V
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
-
P
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
E
-
E
-
V
T
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
---
G
D
T
Y
T
---------
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
---------------
458
Blastp_CBE
44.32
42%
-64
- C3 -
-
6ATE
4.5
-
SRC_HUMAN
A:
[10-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
--------------
P
E
---
A
F
--
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
-------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
371
Blastp_CBE
44.30
43%
-70
- C3 -
-
5D10
6.4
-
SRC_CHICK
B:
[10-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
------------------------
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
474
Blastp_CBE
44.29
42%
-59
- C3 -
-
1YOL
6.6
-
SRC_HUMAN
B:
[9-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
--
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
G
E
T
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
-------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
373
Blastp_CBE
44.28
43%
-71
- C3 -
-
3LOK
4.3
-
SRC_CHICK
B:
[11-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
--
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
--------------------------
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
228
Blastp_CBE
44.27
49%
-12
- C3 -
-
5HU9
11.5
-
ABL1_HUMAN
A:
[9-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-------------
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
217
Blastp_CBE
44.24
52%
-17
- C3 -
-
4UEU
4.0
-
?
A:
[6-257]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
R
S
-------
E
I
T
--------
L
E
R
K
L
G
S
G
Q
F
G
-----
E
V
Y
E
G
K
W
R
N
Y--
N
---
I
-
E
-
V
A
V
K
T
L
K
E
G
T
--
M
---
S
---
V
E
---
E
F
L
Q
E
A
Q
I
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
T
K
E
-
P
P
-
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
-
D
C
-
E
G
H
-
T
-
V
N
-
A
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
V
K
V
A
D
F
G
L
A
R
L
I
---------------
A
K
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
-
G
S
E
V
I
E
Q
V
E
R
G
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
---------------
411
Blastp_CBE
44.03
43%
-62
- C3 -
-
3EN7
5.6
-
SRC_CHICK
A:
[9-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
---------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
---
G
-----
E
V
W
M
G
T
W
N
--------
T
-
R
-
V
A
I
K
T
L
K
P
------------------
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
364
Blastp_CBE
44.08
43%
-72
- C3 -
-
6HVF
6.3
-
?
A:
[10-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
--
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
---------------------
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
244
Blastp_CBE
44.06
49%
-22
- C3 -
-
2E2B
11.5
-
ABL1_HUMAN
A:
[10-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
------
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
----
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
300
Blastp_CBE
44.03
48%
-17
- C3 -
-
3IK3
12.2
-
ABL1_MOUSE
A:
[5-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
------
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
377
Blastp_CBE
43.98
43%
-65
- C3 -
-
2QQ7
4.7
-
SRC_CHICK
B:
[11-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
--
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
------------------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
512
Blastp_CBE
43.96
44%
-42
- C3 -
-
3D7T
7.8
-
CSK_HUMAN
A:
[7-252]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
A
L
N
M
K
-------
E
L
K
--------
L
L
Q
T
I
G
K
G
E
F
G
-----
D
V
M
L
G
D
Y
R
G
---
N
-----
K
-
V
A
V
K
C
I
K
N
D
A
--
T
---
A
---
Q
----
A
F
L
A
E
A
S
V
M
T
Q
L
R
H
S
N
L
V
Q
L
L
G
V
I
V
E
E
-
K
G
G
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
-
S
R
G
R
-
S
-
V
-
L
G
-
G
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
E
D
N
V
A
K
V
S
D
F
G
-----------------------
P
V
K
W
T
A
P
E
A
L
R
E
A
A
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
R
V
P
Y
P
R
I
P
-
L
K
D
V
V
P
R
V
E
K
G
Y
K
M
D
A
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
---------------
271
Blastp_CBE
43.86
49%
-12
- C3 -
-
3MS9
11.7
-
ABL1_MOUSE
A:
[10-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
--------------
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
513
Blastp_CBE
43.75
44%
-42
- C3 -
-
1BYG
7.5
-
CSK_HUMAN
A:
[15-261]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
W
A
L
N
M
K
-------
E
L
K
--------
L
L
Q
T
I
G
K
G
E
F
G
-----
D
V
M
L
G
D
Y
R
G
---
N
-----
K
-
V
A
V
K
C
I
K
N
D
-------
A
---
Q
----
A
F
L
A
E
A
S
V
M
T
Q
L
R
H
S
N
L
V
Q
L
L
G
V
I
V
E
E
---G
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
-
S
R
G
R
-
S
-
V
-
L
G
-
G
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
E
D
N
V
A
K
V
S
D
F
G
L
---------------------
L
P
V
K
W
T
A
P
E
A
L
R
E
K
K
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
R
V
P
Y
P
R
I
P
-
L
K
D
V
V
P
R
V
E
K
G
Y
K
M
D
A
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
---------------
352
Blastp_CBE
43.75
43%
-64
- C3 -
-
2QLQ
2.8
-
SRC_CHICK
B:
[10-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
-------------------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
--------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
304
Blastp_CBE
43.75
48%
-18
- C3 -
-
6BL8
6.2
-
ABL1_HUMAN
B:
[3-254]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
---
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
F
T
--
A
H
---
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
281
Blastp_CBE
43.75
49%
-10
- C3 -
-
1FPU
7.4
-
ABL1_MOUSE
B:
[10-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-----
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
518
Blastp_CBE
43.63
41%
-34
- C3 -
-
6Q7D
11.9
-
?
A:
[6-278]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
-------
L
---------------
K
---------------
F
-
T
T
-
E
I
H
P
S
-------
C
V
T
--------
R
Q
K
V
I
G
A
G
E
F
G
EVYKG
M
L
K
T
----
K
---
E
---
V
-
P
-
V
A
I
K
T
L
K
A
G
Y
--
T
---
E
---
K
Q
RV-
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
-
E
K
-
D
-
G
-
E
-
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
---------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
-
I
L
D
------
261
Blastp_CBE
43.72
49%
-17
- C3 -
-
3OXZ
11.9
-
ABL1_MOUSE
A:
[5-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
--------------
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
------------
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
354
Blastp_CBE
43.68
43%
-78
- C3 -
-
2HWP
2.7
-
SRC_CHICK
B:
[11-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
---
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
-------------------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
-------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
266
Blastp_CBE
43.63
49%
-14
- C3 -
-
3MSS
11.4
-
ABL1_MOUSE
D:
[10-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
--------------
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
498
Blastp_CBE
43.61
42%
-59
- C3 -
-
4LGH
5.6
-
SRC_CHICK
B:
[3-262]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
-
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
---------------------
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
412
Blastp_CBE
43.45
43%
-74
- C3 -
-
3EN6
6.0
-
SRC_CHICK
B:
[10-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
--
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
------------------------
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
------
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
-------------------------
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
268
Blastp_CBE
43.44
49%
-16
- C3 -
-
3MSS
11.5
-
ABL1_MOUSE
B:
[10-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
--------------
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
356
Blastp_CBE
43.40
43%
-68
- C3 -
-
2HWO
3.2
-
SRC_CHICK
B:
[11-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
--
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
------------------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
233
Blastp_CBE
43.32
49%
-13
- C3 -
-
2HYY
11.4
-
ABL1_HUMAN
C:
[6-259]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
K
E
-
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
---
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
269
Blastp_CBE
43.09
49%
-12
- C3 -
-
3MSS
11.6
-
ABL1_MOUSE
A:
[10-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
--------------
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
524
Blastp_CBE
43.05
41%
-27
- C3 -
-
6HEV
11.5
-
A:
[6-278]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
-------
L
---------------
K
---------------
F
-
T
T
-
E
I
H
P
S
-------
C
V
T
--------
R
Q
K
V
I
G
A
G
E
F
G
EVYKG
M
L
-----
K
K
---
E
---
V
-
P
-
V
A
I
K
T
L
K
A
G
Y
--
T
---
E
---
K
Q
RV-
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
-
E
K
-
D
-
G
-
E
-
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
--------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
-
I
L
D
------
515
Blastp_CBE
42.95
41%
-29
- C3 -
-
6Q7G
11.8
-
?
A:
[7-278]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------
L
---------------
K
---------------
F
-
T
T
-
E
I
H
P
S
-------
C
V
T
--------
R
Q
K
V
I
G
A
G
E
F
G
EVYKG
M
L
K
T
----
K
---
E
---
V
-
P
-
V
A
I
K
T
L
K
A
G
Y
--
T
---
E
---
K
Q
RV-
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
-
E
K
-
D
-
G
-
E
-
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
----------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
-
I
L
D
------
243
Blastp_CBE
42.95
49%
-16
- C3 -
-
2E2B
12.0
-
ABL1_HUMAN
B:
[10-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
----------
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
------
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
510
Blastp_CBE
42.92
43%
-51
- C3 -
-
4LGG
6.2
-
B:
[5-255]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
G
Q
G
C
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
267
Blastp_CBE
42.84
49%
-12
- C3 -
-
3MSS
11.6
-
ABL1_MOUSE
C:
[10-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
--------------
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
363
Blastp_CBE
42.66
43%
-64
- C3 -
-
6HVF
6.7
-
?
B:
[11-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
--
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
---------------------
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
-------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
414
Blastp_CBE
42.55
43%
-63
- C3 -
-
3EN5
6.2
-
SRC_CHICK
A:
[13-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
-
F
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
-------------------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
--------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
517
Blastp_CBE
42.50
41%
-30
- C3 -
-
6Q7E
11.6
-
?
A:
[7-278]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------
L
---------------
K
---------------
F
-
T
T
-
E
I
H
P
S
-------
C
V
T
--------
R
Q
K
V
I
G
A
G
E
F
G
EVYKG
M
L
K
T
--------
E
---
V
-
P
-
V
A
I
K
T
L
K
A
G
Y
--
T
---
E
---
K
Q
RV-
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
-
E
K
-
D
-
G
-
E
-
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
----------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
-
I
L
D
------
499
Blastp_CBE
42.31
42%
-62
* C3 *
-
4LGH
6.9
-
SRC_CHICK
A:
[3-262]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
G
--
G
-----
E
V
W
M
G
T
W
N
G
-------
T
-
R
-
V
A
I
K
T
L
-----------------------
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
520
Blastp_CBE
42.05
41%
-22
- C3 -
-
6Q7B
11.9
-
?
A:
[5-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
V
-------
L
---------------
K
---------------
F
-
T
T
-
E
I
H
P
S
-------
C
V
T
--------
R
Q
K
V
I
G
A
G
E
F
G
EVYKG
M
L
K
T
----
K
---
E
---
V
-
P
-
V
A
I
K
T
L
K
A
G
Y
--
T
---
E
---
K
Q
RV-
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
-
E
K
-
D
-
G
-
E
-
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
------------------
G
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
-
I
L
D
------
372
Blastp_CBE
41.96
43%
-55
- C3 -
-
5D10
5.9
-
SRC_CHICK
A:
[11-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
-------
S
L
R
--------
L
E
V
K
L
G
Q
---------
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---
P
E
---
A
----
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
-------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
519
Blastp_CBE
41.93
41%
-23
- C3 -
-
6Q7C
12.1
-
?
A:
[5-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
V
-------
L
---------------
K
---------------
F
-
T
T
-
E
I
H
P
S
-------
C
V
T
--------
R
Q
K
V
I
G
A
--
F
G
EVYKG
M
L
K
T
----
K
---
E
---
V
-
P
-
V
A
I
K
T
L
K
A
G
Y
--
T
---
E
---
K
Q
RV-
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
-
E
K
-
D
-
G
-
E
-
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
------------------
G
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
-
I
L
D
------
521
Blastp_CBE
41.87
41%
-21
- C3 -
-
6HEY
12.1
-
A:
[6-278]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
-------
L
---------------
K
---------------
F
-
T
T
-
E
I
H
P
S
-------
C
V
T
--------
R
Q
K
V
I
G
A
G
E
F
G
EVYKG
M
L
K
T
S
-------
E
---
V
-
P
-
V
A
I
K
T
L
K
A
G
Y
--
T
---
E
---
K
Q
RV-
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
-
E
K
-
D
-
G
-
E
-
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
-------------------
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
-
I
L
D
------
511
Blastp_CBE
41.53
43%
-57
- C3 -
-
4LGG
5.0
-
SRC_CHICK
A:
[9-255]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
G
Q
G
--
G
-----
E
V
W
M
G
T
W
N
G
---
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
------------------
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
----
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-
G
-
K
-
Y
-
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
------
522
Blastp_CBE
41.44
41%
-20
- C3 -
-
6HEX
10.9
-
A:
[11-278]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
-
E
I
H
P
S
-------
C
V
T
--------
R
Q
K
V
I
G
A
G
E
F
G
EVYKG
M
L
-----
K
K
---
E
---
V
-
P
-
V
A
I
K
T
L
K
A
G
Y
--
T
---
E
---
K
Q
RV-
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
-
E
K
-
D
-
G
-
E
-
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
----------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
-
I
L
D
------
223
Blastp_CBE
41.35
49%
-12
- C3 -
-
3CS9
11.8
-
ABL1_HUMAN
C:
[9-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
----------
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
-----------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
242
Blastp_CBE
41.25
49%
-8
- C3 -
-
4WA9
6.6
-
ABL1_HUMAN
A:
[10-260]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
-------------------------------
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
----
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
Y
T
--
A
H
-
A
-
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
293
Blastp_CBE
41.09
49%
-14
- C3 -
-
6NPE
11.0
-
ABL1_HUMAN
B:
[19-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
--------------
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
----------------------
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
291
Blastp_CBE
41.04
49%
-10
- C3 -
-
6NPU
11.4
-
ABL1_HUMAN
B:
[19-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
--------------
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
-------------------
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
523
Blastp_CBE
41.01
41%
-13
- C3 -
-
6HEW
11.1
-
A:
[11-278]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
-
E
I
H
P
S
-------
C
V
T
--------
R
Q
K
V
I
G
A
G
E
F
G
EVYKG
M
L
-----
K
K
---
E
---
V
-
P
-
V
A
I
K
T
L
K
A
G
Y
--
T
---
E
---
K
Q
RV-
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
-
E
K
-
D
-
G
-
E
-
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
------------------
G
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
-
I
L
D
------
516
Blastp_CBE
40.95
41%
-19
- C3 -
-
6Q7F
10.9
-
?
A:
[11-278]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
-
E
I
H
P
S
-------
C
V
T
--------
R
Q
K
V
I
G
A
G
E
F
G
EVYKG
M
L
K
T
--------
E
---
V
-
P
-
V
A
I
K
T
L
K
A
G
Y
--
T
---
E
---
K
Q
RV-
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
-
E
K
-
D
-
G
-
E
-
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
-----------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
-
I
L
D
------
236
Blastp_CBE
40.93
49%
-19
- C3 -
-
2HZ0
10.1
-
ABL1_HUMAN
B:
[5-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
-----------
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
------
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
----------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
289
Blastp_CBE
40.53
49%
-7
- C3 -
-
6NPV
11.5
-
ABL1_HUMAN
B:
[19-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
--------------
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
-------------------
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
295
Blastp_CBE
40.41
49%
-9
- C3 -
-
3PYY
11.4
-
ABL1_HUMAN
B:
[19-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
--------------
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
-------------------
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
224
Blastp_CBE
40.19
49%
-7
- C3 -
-
3CS9
12.1
-
ABL1_HUMAN
B:
[10-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
-------
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
-----
E
V
Y
E
G
V
W
K
K
Y--
S
---
L
-
T
-
V
A
V
K
T
L
---
T
--
M
---
E
---
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
-
E
-
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
-----------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
---------------
-
* C *
-
:
------------------------------------------------------------------------------------------------------------