@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Screening
Virtual Screening Score
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CDK10_HUMAN: (2020-09-05 )
MAEPDLECEQIRLKCIRKEGFFTVPPEHRLGRCRSVKEFEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKRATAGDCLESSYFKEKPLPCEPELMPTFPHHRNKRAAPATSEGQSKRCKP
Atome Classification :
(510 SA)
.........10........20........30........40........50........60........70........80........90........100...----..----.----.---110-------.-.......120..-----.....130-.-.--.......140.......150.......160.......170-..-......180.......190.----....----..200.......210.......220.......230.-......240.-.-.....250.......260.......270.-..-.-..---.280...-..-..290-----....--....300.......310.......320...--....330.......340.......350.......360
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(pKd)
(pKd)
(Uniprot)
MAEPDL
E
C
E
Q
I
R
L
K
C
I
RKEG
F
F
TVPP
E
H
R
L
G
R
C
R
S
V
K
E
F
E
K
L
N
R
IGEG
T
Y
G
I
V
Y
R
ARDTQT
D
E
I
V
A
L
K
K
V
RMDKEKDGI
P
I
S
S
L
R
E
I
T
L
L
LRLRHP
N
I
V
E
L
K
E
V
V
----
V
G
----
N
----
H
---
L
E
--------
S
-
I
F
L
V
M
G
Y
C
E
Q
D
L
-----
A
S
L
L
E
N---M-P--TPF
S
E
A
Q
V
K
C
I
V
L
Q
V
L
R
G
L
Q
Y
L
H
RN
F
I
I
H
RD
L
K
V
S
N
L
L
M--TD-KGCV
K
T
A
DFG
L
A
R
AYGVPVK----PMTP----
K
V
V
T
L
W
YRA
P
E
L
L
L
GTTTQ
T
T
S
I
D
M
W
A
V
G
C
I
L
A
E
L
L
-AHRPLLPGT
S
-
E
-
I
H
Q
I
D
L
I
V
Q
L
LGTPSENIWPGFSKL
P
L
VG-QY-S-LR---KQP
Y
N
N
L
-
K
H
-KFP
W
------
L
S
E
A
--
G
L
R
L
L
H
F
L
F
MYDPKKRATA
G
D
C
L
E
S
S
YFKE--KPLPCEPELMPTFPHHRNKRAAPATSEGQSKRCKP
2
PsiBlast_PDB
96.05
45%
0
- C- -
-
4ERW
-
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
X
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
559
HHSearch
87.13
40%
-118
- C1 -
-
5G6V
10.7
-
CDK16_HUMAN
A:
[2-291]
------------------------------------
E
T
Y
I
K
L
D
K
L
G
E
G
T
Y
A
T
V
Y
K
G
K
S
K
L
T
D
N
L
V
A
L
K
E
I
R
L
E
H
E
E
-
G
A
P
C
T
A
I
R
E
V
S
L
L
K
D
L
K
H
A
N
I
V
T
L
H
D
I
I
----
H
T
-------------
E
K
--------
S
-
L
T
L
V
F
E
Y
L
D
K
D
L
-----
K
Q
Y
L
D
D
---
C
-
G
--
N
I
I
N
M
H
N
V
K
L
F
L
F
Q
L
L
R
G
L
A
Y
C
H
R
Q
K
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
E
-
R
G
E
L
K
L
A
D
F
G
L
A
R
A
-----
K
----
T
Y
D
N
----
E
V
V
T
L
W
Y
R
P
P
D
I
L
L
G
S
T
D
Y
S
T
Q
I
D
M
W
G
V
G
C
I
F
Y
E
M
A
-
T
G
R
P
L
F
P
G
S
T
-
V
-
E
E
Q
L
H
F
I
F
R
I
L
G
T
P
T
E
E
T
W
P
G
I
L
S
N
E
E
F
K
-
T
Y
-
N
-
Y
P
---
K
Y
R
A
E
A
L
-
L
S
-
H
A
P
R
------
L
D
S
D
--
G
A
D
L
L
T
K
L
L
Q
F
E
G
R
N
R
I
S
A
E
D
A
M
K
H
P
F
F
L
S
--
L
G
E
R
-------------------------------
306
Blastp_CBE
86.44
45%
-47
- C1 -
-
2WIH
8.7
-
CDK2_HUMAN
A:
[2-299]
-------------------------------
P
L
V
D
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
12
PsiBlast_PDB
86.39
45%
-45
- C1 -
-
3PY1
5.8
-
CDK2_HUMAN
A:
[5-302]
-------------------------------
S
P
E
F
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
37
Blastp_CBE
86.36
45%
-52
- C1 -
-
4GCJ
5.7
-
CDK2_HUMAN
A:
[3-302]
-----------------------------
L
G
S
P
E
F
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
300
Blastp_CBE
86.13
45%
-47
- C1 -
-
2WXV
7.5
-
CDK2_HUMAN
A:
[2-299]
-------------------------------
P
L
V
D
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
130
Blastp_CBE
85.99
45%
-50
- C1 -
-
4KD1
7.7
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
302
Blastp_CBE
85.94
45%
-46
- C1 -
-
2WPA
6.3
-
CDK2_HUMAN
A:
[2-299]
-------------------------------
P
L
V
D
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
314
Blastp_CBE
85.93
45%
-45
- C1 -
-
1VYW
6.0
-
CDK2_HUMAN
A:
[2-299]
-------------------------------
P
L
V
D
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
556
HHSearch
85.90
42%
-121
- C1 -
-
1UA2
6.0
-
CDK7_HUMAN
B:
[13-300]
---------------------------------------
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
K
N
T
N
Q
I
V
A
I
K
K
---------
I
N
R
T
A
L
R
E
I
K
L
L
Q
E
L
S
H
P
N
I
I
G
L
L
D
A
F
----
G
H
-------------
K
S
--------
N
-
I
S
L
V
F
D
F
M
E
T
D
L
-----
E
V
I
I
K
D
---
N
-
S
--
L
V
L
T
P
S
H
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
--
D
E
-
N
G
V
L
K
L
A
D
F
G
L
A
K
S
F
G
S
P
N
R
----
A
Y
T
H
----
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
-
L
R
V
P
F
L
P
G
D
S
-
D
-
L
D
Q
L
T
R
I
F
E
T
L
G
T
P
T
E
E
Q
W
P
D
M
C
S
L
P
D
Y
V
----
T
-
F
K
---
S
F
P
G
I
P
L
-
H
H
-
I
F
S
A
------
A
G
D
D
--
L
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
S
N
--
R
P
G
--------------------------------
507
Blastp_CBE
85.70
43%
-88
- C1 -
-
1UNL
7.1
-
CDK5_HUMAN
A:
[1-288]
-----------------------------------
M
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
E
T
H
E
I
V
A
L
K
R
V
R
L
D
D
D
D
E
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
----
H
S
----
D
---------
K
--------
K
-
L
T
L
V
F
E
F
C
D
Q
D
L
-----
K
K
Y
F
D
S
---
C
-
N
--
G
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
R
-
N
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
R
----
C
Y
S
A
----
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
-
V
-
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
-
P
Y
-
P
-
M
Y
---
P
A
T
-
T
S
L
-
V
N
-
V
V
P
K
------
L
N
A
T
--
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
-------------------------------------
87
Blastp_CBE
85.66
45%
-44
- C1 -
-
3QZH
5.0
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
52
Blastp_CBE
85.60
45%
-49
- C1 -
-
3RM7
5.0
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
265
Blastp_CBE
85.58
45%
-48
- C1 -
-
1PXI
4.5
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
244
Blastp_CBE
85.53
45%
-50
- C1 -
-
2B53
6.5
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
6
PsiBlast_PDB
85.53
45%
-39
- C1 -
-
3PXF
6.2
-
CDK2_HUMAN
A:
[5-302]
-------------------------------
S
P
E
F
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
310
Blastp_CBE
85.38
45%
-47
- C1 -
-
2BPM
5.5
-
CDK2_HUMAN
A:
[2-299]
-------------------------------
P
L
V
D
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
312
Blastp_CBE
85.36
45%
-45
- C1 -
-
2BKZ
4.9
-
CDK2_HUMAN
A:
[2-299]
-------------------------------
P
L
V
D
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
78
Blastp_CBE
85.31
45%
-49
- C1 -
-
3R7E
4.7
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
221
Blastp_CBE
85.24
45%
-50
- C1 -
-
2CLX
3.8
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
466
Blastp_CBE
85.22
45%
-54
- C1 -
-
4RJ3
7.3
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
L
I
R
L
D
T
-------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
49
Blastp_CBE
85.18
45%
-44
- C1 -
-
3ROY
5.7
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
85
Blastp_CBE
85.07
45%
-46
- C1 -
-
3R1Q
5.7
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
217
Blastp_CBE
85.02
45%
-50
- C1 -
-
2I40
7.6
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
-------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
503
Blastp_CBE
84.96
42%
-113
- C1 -
-
1V0P
7.9
-
CDC2H_PLAFK
A:
[1-286]
-----------------------------------
M
E
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
N
Y
-
G
E
T
F
A
L
K
K
I
R
L
E
K
E
D
E
G
I
P
S
T
T
I
R
E
I
S
I
L
K
E
L
K
H
S
N
I
V
K
L
Y
D
V
I
----------
H
----
T
---
K
K
--------
R
-
L
V
L
V
F
E
H
L
D
Q
D
L
-----
K
K
L
L
D
V
---
C
-
E
--
G
G
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
R
-
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
G
-----------------
I
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
-
N
G
T
P
L
F
P
G
V
S
-
E
-
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
E
L
P
----------
K
---
Y
D
P
N
F
T
V
-
Y
E
-
P
L
P
W
ESFLKG
L
D
E
S
--
G
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
K
E
-------------------------------------
14
PsiBlast_PDB
85.02
45%
-47
- C1 -
-
3QQF
4.7
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
92
Blastp_CBE
85.01
45%
-47
- C1 -
-
3QX4
5.0
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
566
HHSearch
84.90
44%
-70
- C1 -
-
6Q4G
4.7
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
E
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
----
H
T
-------------
E
N
--------
K
-
L
Y
L
V
F
E
F
L
H
Q
D
L
-----
K
K
F
M
D
A
---
S
A
L
--
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
--
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
--
V
T
K
P
V
P
-----------------------------
84
Blastp_CBE
84.98
45%
-42
- C1 -
-
3R1S
5.3
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
181
Blastp_CBE
84.97
45%
-45
- C1 -
-
2XMY
5.5
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
---
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
173
Blastp_CBE
84.96
45%
-48
- C1 -
-
3F5X
7.6
-
CDK2_HUMAN
C:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
96
Blastp_CBE
84.94
45%
-53
- C1 -
-
3QU0
5.8
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
56
Blastp_CBE
84.91
45%
-52
- C1 -
-
3RK7
5.5
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
250
Blastp_CBE
84.90
45%
-52
- C1 -
-
1Y8Y
5.6
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
135
Blastp_CBE
84.88
45%
-51
- C1 -
-
4FKU
6.9
-
CDK2_HUMAN
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
88
Blastp_CBE
84.87
45%
-45
- C1 -
-
3QZG
4.5
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
82
Blastp_CBE
84.87
45%
-42
- C1 -
-
3R28
5.7
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
69
Blastp_CBE
84.84
45%
-46
- C1 -
-
3R8U
4.9
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
83
Blastp_CBE
84.82
45%
-46
- C1 -
-
3R1Y
4.5
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
248
Blastp_CBE
84.80
45%
-48
- C1 -
-
1YKR
5.9
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
208
Blastp_CBE
84.79
45%
-45
- C1 -
-
2UUE
5.7
-
CDK2_HUMAN
C:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
81
Blastp_CBE
84.78
45%
-41
- C1 -
-
3R6X
5.4
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
205
Blastp_CBE
84.75
45%
-47
- C1 -
-
2V0D
2.5
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
17
PsiBlast_PDB
84.73
45%
-48
- C1 -
-
3QQJ
5.2
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
222
Blastp_CBE
84.67
45%
-49
- C1 -
-
2C6O
5.7
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
91
Blastp_CBE
84.67
45%
-48
- C1 -
-
3QXO
4.9
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
160
Blastp_CBE
84.65
45%
-46
- C1 -
-
3TIY
3.5
-
CDK2_HUMAN
A:
[2-294]
------------------------------------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
57
Blastp_CBE
84.64
45%
-52
- C1 -
-
3RK5
5.0
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
9
PsiBlast_PDB
84.64
45%
-49
- C1 -
-
3PXY
5.6
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
103
Blastp_CBE
84.62
45%
-48
- C1 -
-
3QTQ
4.4
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
174
Blastp_CBE
84.55
45%
-49
- C1 -
-
3F5X
6.9
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
-
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
126
Blastp_CBE
84.56
45%
-47
- C1 -
-
5ANE
3.4
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
100
Blastp_CBE
84.55
45%
-44
- C1 -
-
3QTU
5.1
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
206
Blastp_CBE
84.53
45%
-53
- C1 -
-
2UZO
5.3
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
13
PsiBlast_PDB
84.52
45%
-49
- C1 -
-
3QL8
4.9
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
298
Blastp_CBE
84.50
45%
-57
- C1 -
-
3PJ8
6.0
-
CDK2_HUMAN
A:
[1-295]
----------------------------------
G
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
259
Blastp_CBE
84.48
45%
-46
- C1 -
-
1PXO
3.3
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
223
Blastp_CBE
84.42
45%
-47
- C1 -
-
2C6M
6.5
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
86
Blastp_CBE
84.43
45%
-44
- C1 -
-
3QZI
5.3
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
94
Blastp_CBE
84.42
45%
-47
- C1 -
-
3QWK
5.9
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
70
Blastp_CBE
84.42
45%
-46
- C1 -
-
3R8P
3.7
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
226
Blastp_CBE
84.36
45%
-48
- C1 -
-
2C6I
6.3
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
228
Blastp_CBE
84.39
45%
-49
- C1 -
-
2C68
6.7
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
20
PsiBlast_PDB
84.38
45%
-50
- C1 -
-
3QRU
5.1
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
10
PsiBlast_PDB
84.36
45%
-40
- C1 -
-
3PXZ
6.1
-
CDK2_HUMAN
A:
[5-302]
-------------------------------
S
P
E
F
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
73
Blastp_CBE
84.33
45%
-46
- C1 -
-
3R83
5.7
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
16
PsiBlast_PDB
84.29
45%
-43
- C1 -
-
3QQH
6.9
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
68
Blastp_CBE
84.28
45%
-44
- C1 -
-
3R8V
5.2
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
427
Blastp_CBE
84.25
45%
-52
- C1 -
-
5MHQ
7.1
-
?
A:
[6-302]
--------------------------------
P
E
F
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
-
I
R
L
---------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
511
Blastp_CBE
84.16
43%
-94
- C1 -
-
1UNG
5.3
-
CDK5_HUMAN
A:
[1-288]
-----------------------------------
M
Q
K
Y
E
K
L
E
K
I
----
Y
G
T
V
F
K
A
K
N
R
E
T
H
E
I
V
A
L
K
R
V
R
L
D
D
D
D
E
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
----
H
S
----
D
---------
K
--------
K
-
L
T
L
V
F
E
F
C
D
Q
D
L
-----
K
K
Y
F
D
S
---
C
-
N
--
G
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
R
-
N
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
R
----
C
Y
S
A
----
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
-
V
-
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
-
P
Y
-
P
-
M
Y
---
P
A
T
-
T
S
L
-
V
N
-
V
V
P
K
------
L
N
A
T
--
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
-------------------------------------
225
Blastp_CBE
84.19
45%
-48
- C1 -
-
2C6K
6.6
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
11
PsiBlast_PDB
84.19
45%
-50
- C1 -
-
3PY0
5.4
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
43
Blastp_CBE
84.16
45%
-46
- C1 -
-
3S00
4.4
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
74
Blastp_CBE
84.13
45%
-46
- C1 -
-
3R7Y
5.5
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
159
Blastp_CBE
84.12
45%
-46
- C1 -
-
3TIZ
5.2
-
CDK2_HUMAN
A:
[2-294]
------------------------------------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
117
Blastp_CBE
84.11
45%
-59
- C1 -
-
5IEX
6.1
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
----------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
90
Blastp_CBE
84.06
45%
-44
- C1 -
-
3QXP
5.3
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
46
Blastp_CBE
84.06
45%
-46
- C1 -
-
3RPV
5.8
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
39
Blastp_CBE
84.06
45%
-49
- C1 -
-
4EZ3
4.5
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
561
HHSearch
83.96
43%
-126
- C1 -
-
1V0O
6.0
-
CDC2H_PLAFK
B:
[3-286]
-------------------------------------
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
N
-
Y
G
E
T
F
A
L
K
K
I
R
L
----------
T
I
R
E
I
S
I
L
K
E
L
K
H
S
N
I
V
K
L
Y
D
V
I
----
H
T
-------------
K
K
--------
R
-
L
V
L
V
F
E
H
L
D
Q
D
L
-----
K
K
L
L
D
V
---
C
-
E
--
G
G
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
R
-
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
G
I
P
V
R
----
K
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
-
N
G
T
P
L
F
P
G
V
S
-
E
-
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
E
L
P
K
Y
D
-
P
N
-
F
-
T
----
V
Y
E
P
L
P
W
-
E
S
-
F
L
K
G
------
L
D
E
S
--
G
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
K
E
-------------------------------------
247
Blastp_CBE
84.02
45%
-48
- C1 -
-
2A0C
6.5
-
CDK2_HUMAN
X:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
227
Blastp_CBE
84.01
45%
-49
- C1 -
-
2C69
6.2
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
182
Blastp_CBE
83.99
45%
-44
- C1 -
-
2X1N
6.4
-
CDK2_HUMAN
C:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
19
PsiBlast_PDB
83.98
45%
-43
- C1 -
-
3QRT
6.0
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
277
Blastp_CBE
83.93
45%
-63
- C1 -
-
1H0W
3.7
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
----------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
235
Blastp_CBE
83.97
45%
-42
- C1 -
-
2C5O
4.1
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
123
Blastp_CBE
83.96
45%
-47
- C1 -
-
5ANJ
4.5
-
CDK2_HUMAN
A:
[3-294]
-------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
61
Blastp_CBE
83.93
45%
-45
- C1 -
-
3RAI
5.4
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
48
Blastp_CBE
83.93
45%
-43
- C1 -
-
3RPO
5.4
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
132
Blastp_CBE
83.85
45%
-45
- C1 -
-
4FX3
5.5
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
93
Blastp_CBE
83.86
45%
-44
- C1 -
-
3QX2
5.0
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
15
PsiBlast_PDB
83.85
45%
-45
- C1 -
-
3QQG
5.3
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
80
Blastp_CBE
83.84
45%
-43
- C1 -
-
3R71
5.3
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
58
Blastp_CBE
83.83
45%
-49
- C1 -
-
3RJC
5.6
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
18
PsiBlast_PDB
83.81
45%
-45
- C1 -
-
3QQL
4.5
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
304
Blastp_CBE
83.74
45%
-47
- C1 -
-
2WIP
7.2
-
CDK2_HUMAN
A:
[2-299]
-------------------------------
P
L
V
D
M
E
N
F
Q
K
V
E
K
I
-----
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
72
Blastp_CBE
83.76
45%
-48
- C1 -
-
3R8L
4.5
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
79
Blastp_CBE
83.74
45%
-46
- C1 -
-
3R73
5.6
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
65
Blastp_CBE
83.74
45%
-50
- C1 -
-
3R9H
5.0
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
26
Blastp_CBE
83.74
45%
-48
- C1 -
-
6Q4H
5.9
-
CDK2_HUMAN
A:
[8-302]
----------------------------------
F
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
311
Blastp_CBE
83.72
45%
-43
- C1 -
-
2BKZ
4.6
-
CDK2_HUMAN
C:
[5-299]
----------------------------------
D
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
29
Blastp_CBE
83.69
45%
-48
- C1 -
-
6Q4C
3.2
-
CDK2_HUMAN
A:
[7-302]
---------------------------------
E
F
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
66
Blastp_CBE
83.68
45%
-44
- C1 -
-
3R9D
5.3
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
278
Blastp_CBE
83.67
45%
-52
- C1 -
-
1H0V
4.1
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
-------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
288
Blastp_CBE
83.60
45%
-46
- C1 -
-
1FIN
3.7
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
308
Blastp_CBE
83.64
45%
-42
- C1 -
-
2C4G
5.2
-
CDK2_HUMAN
A:
[2-299]
-------------------------------
P
L
V
D
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
95
Blastp_CBE
83.60
45%
-48
- C1 -
-
3QWJ
5.1
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
236
Blastp_CBE
83.58
45%
-43
- C1 -
-
2C5N
6.0
-
CDK2_HUMAN
C:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
157
Blastp_CBE
83.54
45%
-47
- C1 -
-
3UNJ
6.8
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
264
Blastp_CBE
83.51
45%
-45
- C1 -
-
1PXJ
4.1
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
42
Blastp_CBE
83.54
45%
-52
- C1 -
-
3S0O
4.3
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
--
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
305
Blastp_CBE
83.47
45%
-40
- C1 -
-
2WIH
8.3
-
CDK2_HUMAN
C:
[5-299]
----------------------------------
D
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
185
Blastp_CBE
83.51
45%
-42
- C1 -
-
2WEV
6.0
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
234
Blastp_CBE
83.45
45%
-40
- C1 -
-
2C5O
3.5
-
CDK2_HUMAN
C:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
97
Blastp_CBE
83.46
45%
-49
- C1 -
-
3QTZ
5.1
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
75
Blastp_CBE
83.46
45%
-44
- C1 -
-
3R7V
4.6
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
98
Blastp_CBE
83.45
45%
-48
- C1 -
-
3QTX
4.5
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
309
Blastp_CBE
83.41
45%
-40
- C1 -
-
2BPM
5.6
-
CDK2_HUMAN
C:
[5-299]
----------------------------------
D
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
229
Blastp_CBE
83.36
45%
-47
- C1 -
-
2C5Y
7.7
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
53
Blastp_CBE
83.39
45%
-43
- C1 -
-
3RM6
6.0
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
-
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
67
Blastp_CBE
83.38
45%
-51
- C1 -
-
3R8Z
3.9
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
--------
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
104
Blastp_CBE
83.36
45%
-48
- C1 -
-
3QQK
3.9
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
219
Blastp_CBE
83.35
45%
-42
- C1 -
-
2EXM
4.1
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
224
Blastp_CBE
83.34
45%
-45
- C1 -
-
2C6L
5.9
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
139
Blastp_CBE
83.32
45%
-61
- C1 -
-
4FKQ
6.3
-
CDK2_HUMAN
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
22
Blastp_CBE
83.31
45%
-43
- C1 -
-
5OO3
4.0
-
CDK2_HUMAN
A:
[7-299]
------------------------------------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
C
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
A
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
7
PsiBlast_PDB
83.31
45%
-37
- C1 -
-
3PXQ
5.3
-
CDK2_HUMAN
A:
[5-302]
-------------------------------
S
P
E
F
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
25
Blastp_CBE
83.30
45%
-52
- C1 -
-
6Q4J
4.7
-
CDK2_HUMAN
A:
[8-302]
----------------------------------
F
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
260
Blastp_CBE
83.29
45%
-47
- C1 -
-
1PXN
6.1
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
258
Blastp_CBE
83.23
45%
-45
- C1 -
-
1PXP
6.7
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
237
Blastp_CBE
83.24
45%
-42
- C1 -
-
2C5N
5.7
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
165
Blastp_CBE
83.23
45%
-43
- C1 -
-
3NS9
7.0
-
CDK2_HUMAN
A:
[3-294]
-------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
307
Blastp_CBE
83.22
45%
-41
- C1 -
-
2C4G
5.3
-
CDK2_HUMAN
C:
[4-299]
---------------------------------
V
D
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
276
Blastp_CBE
83.17
45%
-47
- C1 -
-
1HCK
5.9
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
89
Blastp_CBE
83.19
45%
-46
- C1 -
-
3QZF
4.5
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
180
Blastp_CBE
83.16
45%
-41
- C1 -
-
2XNB
7.3
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
--
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
184
Blastp_CBE
83.17
45%
-40
- C1 -
-
2WEV
6.4
-
CDK2_HUMAN
C:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
177
Blastp_CBE
83.16
45%
-46
- C1 -
-
3EJ1
5.6
-
CDK2_HUMAN
C:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
54
Blastp_CBE
83.14
45%
-49
- C1 -
-
3RKB
4.8
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
176
Blastp_CBE
83.10
45%
-45
- C1 -
-
3EOC
6.7
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
303
Blastp_CBE
83.04
45%
-46
- C1 -
-
2WIP
7.1
-
CDK2_HUMAN
C:
[5-299]
----------------------------------
D
M
E
N
F
Q
K
V
E
K
I
-----
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
209
Blastp_CBE
83.09
45%
-43
- C1 -
-
2UUE
4.7
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
284
Blastp_CBE
83.04
45%
-44
- C1 -
-
1FVV
7.0
-
CDK2_HUMAN
C:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
156
Blastp_CBE
82.99
45%
-44
- C1 -
-
3UNK
6.9
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
179
Blastp_CBE
82.96
45%
-45
- C1 -
-
3EID
6.7
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
230
Blastp_CBE
82.97
45%
-50
- C1 -
-
2C5X
5.1
-
CDK2_HUMAN
C:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
178
Blastp_CBE
82.96
45%
-46
- C1 -
-
3EJ1
5.6
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
504
Blastp_CBE
82.94
44%
-88
- C1 -
-
4AU8
4.8
-
CDK5_HUMAN
B:
[6-292]
------------------------------------
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
E
T
H
E
I
V
A
L
K
R
V
R
L
----
E
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
----
H
S
--------------
K
--------
K
-
L
T
L
V
F
E
F
C
D
Q
D
L
-----
K
K
Y
F
D
S
---
C
-
N
--
G
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
R
-
N
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
--------------
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
-
V
-
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
-
P
Y
-
P
-
M
Y
---
P
A
T
-
T
S
L
-
V
N
-
V
V
P
K
------
L
N
A
T
--
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
-------------------------------------
290
Blastp_CBE
82.89
45%
-52
- C1 -
-
1E1X
4.1
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
216
Blastp_CBE
82.92
45%
-46
- C1 -
-
2I40
7.5
-
CDK2_HUMAN
C:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
186
Blastp_CBE
82.87
45%
-57
- C1 -
-
2W1H
6.6
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
131
Blastp_CBE
82.89
45%
-42
- C1 -
-
4FX3
6.3
-
CDK2_HUMAN
C:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
31
Blastp_CBE
82.87
45%
-49
- C1 -
-
6Q4A
2.8
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
-
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
118
Blastp_CBE
82.84
45%
-58
- C1 -
-
5IEV
6.4
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
55
Blastp_CBE
82.82
45%
-46
- C1 -
-
3RK9
4.6
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
562
HHSearch
82.81
42%
-89
- C1 -
-
1UNL
7.1
-
CDK5_HUMAN
A:
[2-291]
------------------------------------
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
E
T
H
E
I
V
A
L
K
R
V
R
L
D
D
D
D
E
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
----
H
S
-------------
D
K
--------
K
-
L
T
L
V
F
E
F
C
D
Q
D
L
-----
K
K
Y
F
D
S
---
C
-
N
--
G
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
R
-
N
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
R
----
C
Y
S
A
----
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
-
N
A
G
R
P
L
F
P
G
N
-
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
-
P
Y
-
P
-
M
----
Y
P
A
T
T
S
L
-
V
N
-
V
V
P
K
------
L
N
A
T
--
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
--
F
C
P
--------------------------------
232
Blastp_CBE
82.80
45%
-43
- C1 -
-
2C5V
5.6
-
CDK2_HUMAN
C:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
273
Blastp_CBE
82.72
45%
-66
- C1 -
-
1KE5
5.6
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
99
Blastp_CBE
82.72
45%
-53
- C1 -
-
3QTW
5.5
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
50
Blastp_CBE
82.72
45%
-48
- C1 -
-
3RNI
5.0
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
332
Blastp_CBE
82.63
45%
-47
- C1 -
-
1W8C
5.2
-
CDK2_HUMAN
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
293
Blastp_CBE
82.68
45%
-56
- C1 -
-
1DI8
5.8
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
133
Blastp_CBE
82.67
45%
-63
- C1 -
-
4FKW
8.0
-
CDK2_HUMAN
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
313
Blastp_CBE
82.64
45%
-38
- C1 -
-
1VYW
5.7
-
CDK2_HUMAN
C:
[5-299]
----------------------------------
D
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
155
Blastp_CBE
82.63
45%
-58
- C1 -
-
3WBL
5.9
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
T
G
E
V
V
A
L
K
K
I
R
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
331
Blastp_CBE
82.62
45%
-50
- C1 -
-
2R3I
6.8
-
CDK2_HUMAN
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
161
Blastp_CBE
82.58
45%
-48
- C1 -
-
3TI1
5.6
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
166
Blastp_CBE
82.56
45%
-44
- C1 -
-
3LFS
5.4
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
158
Blastp_CBE
82.56
45%
-57
- C1 -
-
3ULI
6.6
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
23
Blastp_CBE
82.56
45%
-66
- C1 -
-
5OO1
4.3
-
CDK2_HUMAN
A:
[9-299]
--------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
C
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
-------------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
A
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
285
Blastp_CBE
82.51
45%
-42
- C1 -
-
1FVV
5.8
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
172
Blastp_CBE
82.52
45%
-51
- C1 -
-
3FZ1
3.6
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
233
Blastp_CBE
82.51
45%
-44
- C1 -
-
2C5V
4.6
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
211
Blastp_CBE
82.50
45%
-53
- C1 -
-
2R3R
6.7
-
CDK2_HUMAN
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
287
Blastp_CBE
82.48
45%
-47
- C1 -
-
1FIN
3.8
-
CDK2_HUMAN
C:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
116
Blastp_CBE
82.45
45%
-60
- C1 -
-
5IEY
5.9
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
183
Blastp_CBE
82.44
45%
-43
- C1 -
-
2X1N
6.4
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
299
Blastp_CBE
82.38
45%
-42
- C1 -
-
2WXV
6.9
-
CDK2_HUMAN
C:
[5-299]
----------------------------------
D
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
262
Blastp_CBE
82.43
45%
-52
- C1 -
-
1PXL
4.9
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
301
Blastp_CBE
82.35
45%
-39
- C1 -
-
2WPA
6.2
-
CDK2_HUMAN
C:
[5-299]
----------------------------------
D
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
295
Blastp_CBE
82.38
45%
-53
- C1 -
-
1B39
6.0
-
CDK2_HUMAN
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
271
Blastp_CBE
82.31
45%
-60
- C1 -
-
1KE7
5.7
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
214
Blastp_CBE
82.35
45%
-45
- C1 -
-
2R3F
6.8
-
CDK2_HUMAN
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
324
Blastp_CBE
82.34
45%
-51
- C1 -
-
2R3P
7.0
-
CDK2_HUMAN
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
270
Blastp_CBE
82.32
45%
-61
- C1 -
-
1KE8
5.7
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
243
Blastp_CBE
82.31
45%
-36
- C1 -
-
2B54
8.2
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
296
Blastp_CBE
82.25
45%
-46
- C1 -
-
1B38
6.5
-
CDK2_HUMAN
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
269
Blastp_CBE
82.25
45%
-65
- C1 -
-
1KE9
5.4
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
291
Blastp_CBE
82.26
45%
-48
- C1 -
-
1E1V
4.5
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
266
Blastp_CBE
82.25
45%
-43
- C1 -
-
1PF8
4.6
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
141
Blastp_CBE
82.19
45%
-48
- C1 -
-
4FKO
7.7
-
CDK2_HUMAN
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
325
Blastp_CBE
82.15
45%
-51
- C1 -
-
2R3O
6.3
-
CDK2_HUMAN
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
34
Blastp_CBE
82.14
45%
-58
- C1 -
-
6Q3B
3.3
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
24
Blastp_CBE
82.07
45%
-51
- C1 -
-
6Q4K
2.7
-
CDK2_HUMAN
A:
[8-302]
----------------------------------
F
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
-
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
129
Blastp_CBE
82.06
45%
-56
- C1 -
-
4LYN
6.3
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
199
Blastp_CBE
82.03
45%
-47
- C1 -
-
2VTM
3.3
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
286
Blastp_CBE
81.98
45%
-60
- C1 -
-
1FVT
4.3
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
251
Blastp_CBE
81.92
45%
-54
- C1 -
-
1WCC
3.2
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
134
Blastp_CBE
81.79
45%
-53
- C1 -
-
4FKV
7.8
-
CDK2_HUMAN
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-------------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
197
Blastp_CBE
81.76
45%
-48
- C1 -
-
2VTO
4.4
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
21
Blastp_CBE
81.74
45%
-39
- C1 -
-
5OSM
4.8
-
CDK2_HUMAN
A:
[2-299]
-------------------------------
P
L
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
C
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
A
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
144
Blastp_CBE
81.73
45%
-43
- C1 -
-
4FKI
6.0
-
CDK2_HUMAN
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
---
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
505
Blastp_CBE
81.64
44%
-84
- C1 -
-
4AU8
4.8
-
CDK5_HUMAN
A:
[6-292]
------------------------------------
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
E
T
H
E
I
V
A
L
K
R
---------
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
----
H
------------------------
K
-
L
T
L
V
F
E
F
C
D
Q
D
L
-----
K
K
Y
F
D
S
---
C
-
N
--
G
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
R
-
N
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
R
------
S
A
----
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
-
V
-
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
-
P
Y
-
P
-
M
Y
---
P
A
T
-
T
S
L
-
V
N
-
V
V
P
K
------
L
N
A
T
--
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
-------------------------------------
272
Blastp_CBE
81.69
45%
-61
- C1 -
-
1KE6
5.8
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
175
Blastp_CBE
81.64
45%
-41
- C1 -
-
3EOC
5.5
-
CDK2_HUMAN
C:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
167
Blastp_CBE
81.62
45%
-44
- C1 -
-
3LFQ
5.5
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
190
Blastp_CBE
81.57
45%
-65
- C1 -
-
2VV9
7.5
-
CDK2_HUMAN
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
323
Blastp_CBE
81.56
45%
-46
- C1 -
-
2R3Q
7.4
-
CDK2_HUMAN
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
38
Blastp_CBE
81.53
45%
-36
- C1 -
-
4EZ7
8.5
-
CDK2_HUMAN
A:
[5-302]
-------------------------------
S
P
E
F
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
170
Blastp_CBE
81.51
45%
-50
- C1 -
-
3IGG
6.3
-
CDK2_HUMAN
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
138
Blastp_CBE
81.51
45%
-58
- C1 -
-
4FKR
6.8
-
CDK2_HUMAN
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
261
Blastp_CBE
81.50
45%
-53
- C1 -
-
1PXM
6.5
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
212
Blastp_CBE
81.46
45%
-48
- C1 -
-
2R3H
4.3
-
CDK2_HUMAN
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
142
Blastp_CBE
81.48
45%
-47
- C1 -
-
4FKL
4.0
-
CDK2_HUMAN
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
149
Blastp_CBE
81.46
45%
-49
- C1 -
-
4EK4
4.4
-
CDK2_HUMAN
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
168
Blastp_CBE
81.45
45%
-51
- C1 -
-
3LFN
7.7
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
-------------
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
187
Blastp_CBE
81.40
45%
-63
- C1 -
-
2W17
6.9
-
CDK2_HUMAN
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
-
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
---------K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
210
Blastp_CBE
81.37
45%
-61
- C1 -
-
2R64
5.0
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
76
Blastp_CBE
81.31
45%
-55
- C1 -
-
3R7U
5.0
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
320
Blastp_CBE
81.17
45%
-41
- C1 -
-
6Q4I
4.6
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
L
---
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
47
Blastp_CBE
81.19
45%
-55
- C1 -
-
3RPR
6.4
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
115
Blastp_CBE
81.17
45%
-42
- C1 -
-
5JQ5
7.3
-
CDK2_HUMAN
A:
[3-294]
-------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
231
Blastp_CBE
81.16
45%
-42
- C1 -
-
2C5X
6.7
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
202
Blastp_CBE
81.11
45%
-63
- C1 -
-
2VTI
5.1
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
213
Blastp_CBE
81.06
45%
-46
- C1 -
-
2R3G
5.5
-
CDK2_HUMAN
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
148
Blastp_CBE
81.06
45%
-45
- C1 -
-
4EK5
4.9
-
CDK2_HUMAN
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
200
Blastp_CBE
81.01
45%
-46
- C1 -
-
2VTL
3.5
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
249
Blastp_CBE
80.97
45%
-45
- C1 -
-
1Y91
7.5
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
---------
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
28
Blastp_CBE
80.94
45%
-40
- C1 -
-
6Q4D
3.4
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
27
Blastp_CBE
80.93
45%
-49
- C1 -
-
6Q4E
4.7
-
CDK2_HUMAN
A:
[8-302]
----------------------------------
F
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
317
Blastp_CBE
80.91
45%
-59
- C1 -
-
1GII
5.8
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
H
V
H
Q
D
L
KTFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
560
HHSearch
80.90
42%
-90
- C1 -
-
4AU8
4.8
-
CDK5_HUMAN
B:
[6-293]
------------------------------------
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
E
T
H
E
I
V
A
L
K
R
V
R
L
----
E
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
----
H
S
--------------
K
--------
K
-
L
T
L
V
F
E
F
C
D
Q
D
L
-----
K
K
Y
F
D
S
---
C
-
N
--
G
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
R
-
N
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
--------------
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
-
N
A
G
R
P
L
F
P
G
N
D
V
-
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
-
P
Y
-
P
-
M
Y
---
P
-
A
T
T
S
L
-
V
N
-
V
V
P
K
------
L
N
A
T
--
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
--
F
----------------------------------
280
Blastp_CBE
80.88
45%
-44
- C1 -
-
1H07
5.9
-
CDK2_HUMAN
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
----
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
33
Blastp_CBE
80.87
45%
-50
- C1 -
-
6Q48
3.2
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
188
Blastp_CBE
80.84
45%
-60
- C1 -
-
2W06
7.2
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
30
Blastp_CBE
80.83
45%
-43
- C1 -
-
6Q4B
3.6
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
275
Blastp_CBE
80.82
45%
-43
- C1 -
-
1JSV
4.2
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
62
Blastp_CBE
80.80
45%
-53
- C1 -
-
3RAH
6.1
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
71
Blastp_CBE
80.74
45%
-47
- C1 -
-
3R8M
3.6
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
101
Blastp_CBE
80.73
45%
-54
- C1 -
-
3QTS
4.9
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
194
Blastp_CBE
80.71
45%
-41
- C1 -
-
2VTR
4.9
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
246
Blastp_CBE
80.68
45%
-48
- C1 -
-
2A4L
6.5
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
------------
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
279
Blastp_CBE
80.59
45%
-52
- C1 -
-
1H08
6.7
-
CDK2_HUMAN
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
204
Blastp_CBE
80.59
45%
-60
- C1 -
-
2VTA
3.8
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
64
Blastp_CBE
80.47
45%
-52
- C1 -
-
3R9N
5.5
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
263
Blastp_CBE
80.43
45%
-54
- C1 -
-
1PXK
3.8
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
164
Blastp_CBE
80.42
45%
-57
- C1 -
-
3S2P
5.1
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
77
Blastp_CBE
80.38
45%
-56
- C1 -
-
3R7I
4.9
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
108
Blastp_CBE
80.30
46%
-63
- C1 -
-
3EZV
7.3
-
CDK2_HUMAN
A:
[3-296]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
----------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
128
Blastp_CBE
80.24
45%
-46
- C1 -
-
5A14
9.7
-
CDK2_HUMAN
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
--
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
40
Blastp_CBE
80.18
45%
-42
- C1 -
-
3SQQ
5.8
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
------
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
196
Blastp_CBE
80.16
45%
-58
- C1 -
-
2VTP
4.5
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
60
Blastp_CBE
80.15
45%
-60
- C1 -
-
3RAK
5.5
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
253
Blastp_CBE
80.10
45%
-49
- C1 -
-
1VYZ
4.8
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
35
Blastp_CBE
80.11
45%
-56
- C1 -
-
6GUK
7.4
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
145
Blastp_CBE
80.10
45%
-44
- C1 -
-
4FKG
4.7
-
CDK2_HUMAN
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
---
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
567
HHSearch
79.99
40%
-75
- C1 -
-
3GC0
3.7
-
?
A:
[32-327]
----------------------------------
S
I
D
R
Y
R
R
I
T
K
L
G
E
G
T
Y
G
E
V
Y
K
A
I
D
T
V
T
N
E
T
V
A
I
K
R
I
R
L
E
H
-------
T
A
I
R
E
V
S
L
L
K
E
L
Q
H
R
N
I
I
E
L
K
S
V
I
----
H
H
-------------
N
H
--------
R
-
L
H
L
I
F
E
Y
A
E
N
D
L
-----
K
K
Y
M
D
K
---
N
----
P
D
V
S
M
R
V
I
K
S
F
L
Y
Q
L
I
N
G
V
N
F
C
H
S
R
R
C
L
H
R
D
L
K
P
Q
N
L
L
L
SV-
E
-
T
P
V
L
K
I
G
D
F
G
L
A
R
A
F
-----------------
E
I
I
T
L
W
Y
R
P
P
E
I
L
L
G
S
R
H
Y
S
T
S
V
D
I
W
S
I
A
C
I
W
A
E
M
L
-
M
K
T
P
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
K
I
F
E
V
L
G
L
P
D
D
T
T
W
P
G
V
T
A
L
P
D
W
K
-
Q
--
S
-
F
P
---
K
F
R
G
K
T
L
-
K
R
V
L
G
A
L
------
L
D
D
E
--
G
L
D
L
L
T
A
M
L
E
M
D
P
V
K
R
I
S
A
K
N
A
L
E
H
P
Y
F
S
H
--
N
D
F
--------------------------------
169
Blastp_CBE
80.04
45%
-43
- C1 -
-
3LE6
6.6
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
----------K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
110
Blastp_CBE
79.99
45%
-50
- C1 -
-
5K4J
6.8
-
CDK2_HUMAN
A:
[1-295]
----------------------------------
A
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
------------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
163
Blastp_CBE
79.96
45%
-56
- C1 -
-
3SW4
6.7
-
CDK2_HUMAN
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
294
Blastp_CBE
79.95
45%
-59
- C1 -
-
1CKP
5.1
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
124
Blastp_CBE
79.93
45%
-55
- C1 -
-
5ANI
3.4
-
CDK2_HUMAN
A:
[2-294]
------------------------------------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
140
Blastp_CBE
79.90
45%
-61
- C1 -
-
4FKP
5.8
-
CDK2_HUMAN
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
102
Blastp_CBE
79.90
45%
-54
- C1 -
-
3QTR
5.6
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
322
Blastp_CBE
79.75
45%
-57
- C1 -
-
4NJ3
9.4
-
CDK2_HUMAN
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
--------------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
119
Blastp_CBE
79.72
45%
-55
- C1 -
-
5FP6
4.9
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
------------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
252
Blastp_CBE
79.63
45%
-55
- C1 -
-
1W0X
6.1
-
CDK2_HUMAN
C:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
506
Blastp_CBE
79.62
43%
-103
- C1 -
-
3O0G
6.3
-
CDK5_HUMAN
B:
[6-288]
----------------------------------------
K
L
E
K
I
-----
G
T
V
F
K
A
------
E
I
V
A
L
K
R
V
R
--------
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
----
H
S
----
D
---------
K
--------
K
-
L
T
L
V
F
E
F
C
D
Q
D
L
-----
K
K
Y
F
D
S
---
C
-
N
--
G
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
R
-
N
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
R
----
C
Y
S
A
----
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
-
V
-
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
-
P
Y
-
P
-
M
Y
---
P
A
T
-
T
S
L
-
V
N
-
V
V
P
K
------
L
N
A
T
--
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
-------------------------------------
51
Blastp_CBE
79.59
45%
-57
- C1 -
-
3RMF
6.8
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
122
Blastp_CBE
79.56
45%
-69
- C1 -
-
5ANK
3.7
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---------------
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
--------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
207
Blastp_CBE
79.55
45%
-61
- C1 -
-
2UZN
4.7
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
152
Blastp_CBE
79.53
45%
-61
- C1 -
-
4BZD
7.6
-
CDK2_HUMAN
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
-
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
----------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
500
Blastp_CBE
79.44
42%
-102
- C1 -
-
1V0O
6.0
-
CDC2H_PLAFK
B:
[3-286]
-------------------------------------
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
N
Y
-
G
E
T
F
A
L
K
K
I
R
L
----------
T
I
R
E
I
S
I
L
K
E
L
K
H
S
N
I
V
K
L
Y
D
V
I
----------
H
----
T
---
K
K
--------
R
-
L
V
L
V
F
E
H
L
D
Q
D
L
-----
K
K
L
L
D
V
---
C
-
E
--
G
G
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
R
-
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
G
I
P
V
R
----
K
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
-
N
G
T
P
L
F
P
G
V
S
-
E
-
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
E
L
P
----------
K
---
Y
D
P
N
F
T
V
-
Y
E
-
P
L
P
W
ESFLKG
L
D
E
S
--
G
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
K
E
-------------------------------------
203
Blastp_CBE
79.35
45%
-54
- C1 -
-
2VTH
3.6
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
242
Blastp_CBE
79.37
45%
-61
- C1 -
-
2B55
7.6
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
-----------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
127
Blastp_CBE
79.35
45%
-56
- C1 -
-
5AND
4.0
-
CDK2_HUMAN
A:
[2-294]
------------------------------------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
45
Blastp_CBE
79.32
45%
-58
- C1 -
-
3RPY
4.4
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
193
Blastp_CBE
79.27
45%
-45
- C1 -
-
2VTS
5.9
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
162
Blastp_CBE
79.27
45%
-60
- C1 -
-
3SW7
7.4
-
CDK2_HUMAN
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
245
Blastp_CBE
79.26
45%
-47
- C1 -
-
2B52
5.4
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
---------------
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
329
Blastp_CBE
79.04
45%
-61
- C1 -
-
2R3K
5.8
-
CDK2_HUMAN
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
146
Blastp_CBE
79.07
45%
-59
- C1 -
-
4EK8
7.0
-
CDK2_HUMAN
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
136
Blastp_CBE
79.04
45%
-56
- C1 -
-
4FKT
5.6
-
CDK2_HUMAN
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
330
Blastp_CBE
78.97
45%
-53
- C1 -
-
2R3J
6.3
-
CDK2_HUMAN
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-------------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
321
Blastp_CBE
78.96
45%
-67
- C1 -
-
6GUE
7.8
-
CDK2_HUMAN
A:
[4-298]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
----
H
T
----
N
----
N
-------------
K
-
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
335
Blastp_CBE
78.93
45%
-44
- C1 -
-
2IW8
7.5
-
CDK2_HUMAN
A:
[4-298]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
H
V
D
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
109
Blastp_CBE
78.92
46%
-55
- C1 -
-
3EZR
6.9
-
CDK2_HUMAN
A:
[3-296]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
--------------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
41
Blastp_CBE
78.87
45%
-58
- C1 -
-
3S1H
5.9
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
238
Blastp_CBE
78.78
45%
-63
- C1 -
-
2BTS
4.8
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
-----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
63
Blastp_CBE
78.80
45%
-56
- C1 -
-
3R9O
5.8
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
151
Blastp_CBE
78.78
45%
-50
- C1 -
-
4D1X
4.6
-
CDK2_HUMAN
A:
[3-294]
-------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
328
Blastp_CBE
78.61
45%
-57
- C1 -
-
2R3L
7.6
-
CDK2_HUMAN
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
-----------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
215
Blastp_CBE
78.59
45%
-56
- C1 -
-
2J9M
4.6
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
-----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
327
Blastp_CBE
78.61
45%
-54
- C1 -
-
2R3M
7.0
-
CDK2_HUMAN
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-------------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
348
Blastp_CBE
78.60
45%
-48
- C1 -
-
1H1S
7.0
-
CDK2_HUMAN
A:
[5-299]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
201
Blastp_CBE
78.59
45%
-54
- C1 -
-
2VTJ
4.3
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
---------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
510
Blastp_CBE
78.57
43%
-98
- C1 -
-
1UNG
4.8
-
CDK5_HUMAN
B:
[2-287]
------------------------------------
Q
K
Y
E
K
L
E
K
-------
T
V
F
K
A
-------
I
V
A
L
K
R
V
R
L
D
----
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
----
H
S
----
D
---------
K
--------
K
-
L
T
L
V
F
E
F
C
D
Q
D
L
-----
K
K
Y
F
D
S
---
C
-
N
--
G
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
R
-
N
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
R
----
C
Y
S
A
----
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
-
V
-
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
-
P
Y
-
P
-
M
Y
---
P
A
T
-
T
S
L
-
V
N
-
V
V
P
K
------
L
N
A
T
--
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
--------------------------------------
349
Blastp_CBE
78.50
45%
-41
- C1 -
-
1H1R
7.1
-
CDK2_HUMAN
C:
[5-299]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
501
Blastp_CBE
78.45
42%
-104
- C1 -
-
1V0O
5.7
-
CDC2H_PLAFK
A:
[3-286]
-------------------------------------
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
N
Y
-
G
E
T
F
A
L
K
K
I
R
L
--------
S
T
T
I
R
E
I
S
I
L
K
E
L
K
H
S
N
I
V
K
L
Y
D
V
I
----------
H
----
T
---
K
K
--------
R
-
L
V
L
V
F
E
H
L
D
Q
D
L
-----
K
K
L
L
D
V
---
C
-
E
--
G
G
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
R
-
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
G
I
P
V
R
----
K
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
-
N
G
T
P
L
F
P
G
V
S
-
E
-
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
E
L
P
----------
K
---
Y
D
P
N
F
T
V
-
Y
E
-
P
L
P
W
ESFLKG
L
D
E
S
--
G
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
K
E
-------------------------------------
143
Blastp_CBE
78.43
45%
-58
- C1 -
-
4FKJ
5.2
-
CDK2_HUMAN
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
-------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
147
Blastp_CBE
78.42
45%
-50
- C1 -
-
4EK6
5.9
-
CDK2_HUMAN
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
----------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
------------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
336
Blastp_CBE
78.22
45%
-43
- C1 -
-
5NEV
8.0
-
?
C:
[5-299]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
255
Blastp_CBE
78.28
45%
-61
- C1 -
-
1URW
7.7
-
CDK2_HUMAN
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
-------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
418
Blastp_CBE
78.29
45%
-48
- C1 -
-
3BHV
6.6
-
CDK2_HUMAN
A:
[2-296]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
153
Blastp_CBE
78.28
45%
-55
- C1 -
-
4BGH
6.0
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
367
Blastp_CBE
78.26
45%
-46
- C1 -
-
3DDP
8.8
-
CDK2_HUMAN
C:
[1-295]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
218
Blastp_CBE
78.22
45%
-50
- C1 -
-
2FVD
5.2
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------------
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
--
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
338
Blastp_CBE
78.17
45%
-45
- C1 -
-
5CYI
7.5
-
CDK2_HUMAN
C:
[5-299]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
154
Blastp_CBE
78.22
45%
-55
- C1 -
-
4ACM
6.7
-
CDK2_HUMAN
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
----------K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
492
Blastp_CBE
78.20
41%
-18
- C1 -
-
6GU4
7.3
-
CDK1_HUMAN
A:
[3-294]
--------------------------------
L
G
S
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
H
P
N
I
V
S
L
Q
D
V
L
----
M
Q
----
D
---------
S
--------
R
-
L
Y
L
I
F
E
F
L
S
M
D
L
-----
K
K
Y
L
D
S
---
I
-
P
PG
Q
Y
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
D
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
----
V
Y
T
H
----
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
-
T
K
K
P
L
F
H
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
L
Q
D
Y
K
-
N
T
-
F
-
P
K
---
W
K
P
-
G
S
L
-
A
S
-
H
V
K
N
------
L
D
E
N
--
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
D
-------------------------------------
44
Blastp_CBE
78.19
45%
-54
- C1 -
-
3RZB
4.2
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
292
Blastp_CBE
78.17
45%
-60
- C1 -
-
1DM2
5.0
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
-----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
107
Blastp_CBE
78.08
46%
-58
- C1 -
-
6INL
7.4
-
?
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
-----------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
499
Blastp_CBE
77.81
41%
-17
- C1 -
-
4Y72
6.6
-
CDK1_HUMAN
A:
[3-294]
--------------------------------
L
G
S
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
H
P
N
I
V
S
L
Q
D
V
L
----
M
Q
----
D
---------
S
--------
R
-
L
Y
L
I
F
E
F
L
S
M
D
L
-----
K
K
Y
L
D
S
---
I
-
P
PG
Q
Y
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
D
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
----
V
Y
T
H
----
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
-
T
K
K
P
L
F
H
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
L
Q
D
Y
K
-
N
T
-
F
-
P
K
---
W
K
P
-
G
S
L
-
A
S
-
H
V
K
N
------
L
D
E
N
--
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
D
-------------------------------------
191
Blastp_CBE
77.87
45%
-46
- C1 -
-
2VU3
6.0
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
----
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
171
Blastp_CBE
77.84
45%
-56
- C1 -
-
3IG7
5.2
-
CDK2_HUMAN
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
--------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
497
Blastp_CBE
77.81
41%
-17
- C1 -
-
5HQ0
6.6
-
CDK1_HUMAN
A:
[3-294]
--------------------------------
L
G
S
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
H
P
N
I
V
S
L
Q
D
V
L
----
M
Q
----
D
---------
S
--------
R
-
L
Y
L
I
F
E
F
L
S
M
D
L
-----
K
K
Y
L
D
S
---
I
-
P
PG
Q
Y
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
D
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
----
V
Y
T
H
----
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
-
T
K
K
P
L
F
H
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
L
Q
D
Y
K
-
N
T
-
F
-
P
K
---
W
K
P
-
G
S
L
-
A
S
-
H
V
K
N
------
L
D
E
N
--
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
D
-------------------------------------
59
Blastp_CBE
77.75
45%
-58
- C1 -
-
3RAL
6.1
-
CDK2_HUMAN
A:
[9-302]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
385
Blastp_CBE
77.62
45%
-43
- C1 -
-
6GUF
7.9
-
CDK2_HUMAN
C:
[4-298]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
189
Blastp_CBE
77.64
45%
-52
- C1 -
-
2W05
7.1
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
---------------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
337
Blastp_CBE
77.62
45%
-42
- C1 -
-
5NEV
7.8
-
CDK2_HUMAN
A:
[5-299]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
281
Blastp_CBE
77.60
45%
-54
- C1 -
-
1H00
5.0
-
CDK2_HUMAN
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
------------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
473
Blastp_CBE
77.59
45%
-47
- C1 -
-
4EOK
6.6
-
CDK2_HUMAN
C:
[3-297]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
KDFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
368
Blastp_CBE
77.58
45%
-41
- C1 -
-
3DDP
8.8
-
CDK2_HUMAN
A:
[1-295]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
239
Blastp_CBE
77.56
45%
-52
- C1 -
-
2BTR
4.9
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
--------------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
358
Blastp_CBE
77.54
45%
-44
- C1 -
-
1E9H
5.6
-
CDK2_HUMAN
C:
[1-295]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
283
Blastp_CBE
77.50
45%
-58
- C1 -
-
1G5S
8.0
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
----------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
471
Blastp_CBE
77.39
45%
-41
- C1 -
-
4EOL
5.6
-
CDK2_HUMAN
C:
[3-297]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
KDFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
447
Blastp_CBE
77.45
45%
-44
- C1 -
-
2UZL
5.7
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
36
Blastp_CBE
77.40
45%
-42
- C1 -
-
6GUH
7.6
-
CDK2_HUMAN
A:
[7-302]
---------------------------------
E
F
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
--------
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
372
Blastp_CBE
77.39
45%
-46
- C1 -
-
2CCI
5.9
-
CDK2_HUMAN
A:
[1-295]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
502
Blastp_CBE
77.38
42%
-118
- C1 -
-
1V0P
6.7
-
CDC2H_PLAFK
B:
[2-286]
------------------------------------
E
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
N
Y
-
G
E
T
F
A
L
K
-----------
P
S
T
T
I
R
E
I
S
I
L
K
E
L
K
H
S
N
I
V
K
L
Y
D
V
I
----------
H
----
T
---------------
L
V
L
V
F
E
H
L
D
Q
D
L
-----
K
K
L
L
D
V
---
C
-
E
--
G
G
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
R
-
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
---------------------
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
-
N
G
T
P
L
F
P
G
V
S
-
E
-
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
E
L
P
----------
K
---
Y
D
P
N
F
T
V
-
Y
E
-
P
L
P
W
ESFLKG
L
D
E
S
--
G
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
K
E
-------------------------------------
399
Blastp_CBE
77.25
45%
-43
- C1 -
-
1OI9
6.7
-
CDK2_HUMAN
A:
[4-298]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
398
Blastp_CBE
77.25
45%
-47
- C1 -
-
1OI9
6.7
-
CDK2_HUMAN
C:
[4-298]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
350
Blastp_CBE
77.31
45%
-41
- C1 -
-
1H1R
7.2
-
CDK2_HUMAN
A:
[5-299]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
220
Blastp_CBE
77.29
45%
-51
- C1 -
-
2DUV
5.3
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-------------
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
---------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
470
Blastp_CBE
77.19
45%
-46
- C1 -
-
4EOM
6.0
-
CDK2_HUMAN
A:
[4-298]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
111
Blastp_CBE
77.25
45%
-59
- C1 -
-
1OIT
6.2
-
CDK2_HUMAN
A:
[3-294]
-------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
-
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
S
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
-------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
498
Blastp_CBE
77.24
41%
-18
- C1 -
-
4YC3
3.3
-
CDK1_HUMAN
A:
[5-294]
----------------------------------
S
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
H
P
N
I
V
S
L
Q
D
V
L
----
M
Q
----
D
---------
S
--------
R
-
L
Y
L
I
F
E
F
L
S
M
D
L
-----
K
K
Y
L
D
S
---
I
-
P
PG
Q
Y
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
D
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
----
V
Y
T
-------
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
-
T
K
K
P
L
F
H
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
L
Q
D
Y
K
-
N
T
-
F
-
P
K
---
W
K
P
-
G
S
L
-
A
S
-
H
V
K
N
------
L
D
E
N
--
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
D
-------------------------------------
114
Blastp_CBE
77.19
45%
-52
- C1 -
-
5JQ8
6.6
-
CDK2_HUMAN
A:
[3-294]
-------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
361
Blastp_CBE
77.18
45%
-46
- C1 -
-
5LMK
8.0
-
CDK2_HUMAN
A:
[1-295]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
339
Blastp_CBE
77.07
45%
-44
- C1 -
-
5CYI
7.3
-
CDK2_HUMAN
A:
[5-299]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
378
Blastp_CBE
77.04
45%
-45
- C1 -
-
1P5E
4.3
-
CDK2_HUMAN
A:
[1-295]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
370
Blastp_CBE
77.00
45%
-41
- C1 -
-
2G9X
6.2
-
CDK2_HUMAN
A:
[1-295]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
493
Blastp_CBE
76.97
41%
-14
- C1 -
-
6GU3
7.1
-
CDK1_HUMAN
A:
[3-294]
--------------------------------
L
G
S
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
H
P
N
I
V
S
L
Q
D
V
L
----
M
Q
----
D
---------
S
--------
R
-
L
Y
L
I
F
E
F
L
S
M
D
L
-----
K
K
Y
L
D
S
---
I
-
P
PG
Q
Y
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
D
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
----
V
Y
T
H
----
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
-
T
K
K
P
L
F
H
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
L
Q
D
Y
K
-
N
T
-
F
-
P
K
---
W
K
P
-
G
S
L
-
A
S
-
H
V
K
N
------
L
D
E
N
--
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
D
-------------------------------------
137
Blastp_CBE
76.94
45%
-55
- C1 -
-
4FKS
6.6
-
CDK2_HUMAN
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
195
Blastp_CBE
76.92
45%
-59
- C1 -
-
2VTQ
5.3
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
-----------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
282
Blastp_CBE
76.90
45%
-52
- C1 -
-
1GIH
6.6
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
353
Blastp_CBE
76.89
45%
-44
- C1 -
-
1H1P
5.4
-
CDK2_HUMAN
C:
[5-299]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
431
Blastp_CBE
76.87
45%
-44
- C1 -
-
2IW9
6.8
-
CDK2_HUMAN
A:
[4-298]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KTFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
357
Blastp_CBE
76.86
45%
-46
- C1 -
-
1PKD
8.0
-
CDK2_HUMAN
A:
[1-295]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
362
Blastp_CBE
76.82
45%
-48
- C1 -
-
5L2W
7.6
-
CDK2_HUMAN
A:
[1-295]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
342
Blastp_CBE
76.81
45%
-45
- C1 -
-
4CFW
7.2
-
CDK2_HUMAN
C:
[4-299]
---------------------------------
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
433
Blastp_CBE
76.80
45%
-47
- C1 -
-
2IW6
7.4
-
CDK2_HUMAN
A:
[4-298]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KTFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
476
Blastp_CBE
76.79
45%
-42
- C1 -
-
4EON
6.9
-
CDK2_HUMAN
A:
[2-296]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
347
Blastp_CBE
76.72
45%
-48
- C1 -
-
1H1S
6.8
-
CDK2_HUMAN
C:
[5-299]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
392
Blastp_CBE
76.78
45%
-42
- C1 -
-
4CFN
5.6
-
CDK2_HUMAN
C:
[4-298]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
394
Blastp_CBE
76.75
45%
-45
- C1 -
-
1OIY
6.7
-
CDK2_HUMAN
C:
[4-298]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
472
Blastp_CBE
76.73
45%
-44
- C1 -
-
4EOL
6.5
-
CDK2_HUMAN
A:
[3-297]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
KDFMD
A
S
-
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
192
Blastp_CBE
76.72
45%
-55
- C1 -
-
2VTT
5.2
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
-----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
382
Blastp_CBE
76.69
45%
-47
- C1 -
-
4EOR
7.7
-
CDK2_HUMAN
A:
[1-295]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
435
Blastp_CBE
76.66
45%
-47
- C1 -
-
4EOQ
5.4
-
CDK2_HUMAN
A:
[4-298]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
406
Blastp_CBE
76.56
45%
-40
- C1 -
-
4BCP
5.8
-
CDK2_HUMAN
A:
[2-296]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
351
Blastp_CBE
76.54
45%
-48
- C1 -
-
1H1Q
6.9
-
CDK2_HUMAN
C:
[5-299]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
429
Blastp_CBE
76.60
45%
-48
- C1 -
-
4EOO
5.5
-
CDK2_HUMAN
A:
[2-296]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
397
Blastp_CBE
76.57
45%
-43
- C1 -
-
1OIU
7.2
-
CDK2_HUMAN
A:
[4-298]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
377
Blastp_CBE
76.56
45%
-42
- C1 -
-
1P5E
4.4
-
CDK2_HUMAN
C:
[1-295]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
257
Blastp_CBE
76.54
45%
-73
- C1 -
-
1PYE
5.4
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
---
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
----------
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
------------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
494
Blastp_CBE
76.52
41%
-22
- C1 -
-
6GU2
6.7
-
CDK1_HUMAN
A:
[3-294]
--------------------------------
L
G
S
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
H
P
N
I
V
S
L
Q
D
V
L
----
M
Q
----
D
---------
S
--------
R
-
L
Y
L
I
F
E
F
L
S
M
D
L
-----
K
K
Y
L
D
S
---
I
-
P
PG
Q
Y
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
D
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
----
V
Y
T
-------
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
-
T
K
K
P
L
F
H
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
L
Q
D
Y
K
-
N
T
-
F
-
P
K
---
W
K
P
-
G
S
L
-
A
S
-
H
V
K
N
------
L
D
E
N
--
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
D
-------------------------------------
254
Blastp_CBE
76.51
45%
-58
- C1 -
-
1V1K
5.7
-
CDK2_HUMAN
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
316
Blastp_CBE
76.50
45%
-54
- C1 -
-
1GIJ
6.8
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
H
V
H
Q
D
L
KTFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
440
Blastp_CBE
76.48
45%
-36
- C1 -
-
4EOP
6.5
-
CDK2_HUMAN
C:
[3-297]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
401
Blastp_CBE
76.42
45%
-46
- C1 -
-
1OGU
6.4
-
CDK2_HUMAN
A:
[4-298]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
379
Blastp_CBE
76.32
45%
-44
- C1 -
-
1GY3
4.7
-
CDK2_HUMAN
C:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
422
Blastp_CBE
76.37
45%
-45
- C1 -
-
3BHT
6.2
-
CDK2_HUMAN
A:
[2-296]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
478
Blastp_CBE
76.36
45%
-46
- C1 -
-
4EOJ
5.2
-
CDK2_HUMAN
A:
[4-298]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
KDFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
452
Blastp_CBE
76.33
45%
-45
- C1 -
-
2UZB
6.9
-
CDK2_HUMAN
C:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
375
Blastp_CBE
76.32
45%
-45
- C1 -
-
1QMZ
5.8
-
CDK2_HUMAN
C:
[1-295]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
412
Blastp_CBE
76.31
45%
-46
- C1 -
-
4BCK
5.3
-
CDK2_HUMAN
A:
[2-296]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
428
Blastp_CBE
76.30
45%
-41
- C1 -
-
4EOO
5.7
-
CDK2_HUMAN
C:
[2-296]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
456
Blastp_CBE
76.20
45%
-42
- C1 -
-
2C6T
7.0
-
CDK2_HUMAN
C:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
383
Blastp_CBE
76.26
45%
-38
- C1 -
-
4EOI
5.8
-
CDK2_HUMAN
C:
[1-295]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KDFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
410
Blastp_CBE
76.24
45%
-46
- C1 -
-
4BCN
5.9
-
CDK2_HUMAN
A:
[2-296]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
426
Blastp_CBE
76.22
45%
-47
- C1 -
-
4CFU
7.4
-
CDK2_HUMAN
A:
[5-299]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
438
Blastp_CBE
76.21
45%
-47
- C1 -
-
4BCM
6.8
-
CDK2_HUMAN
C:
[3-297]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
374
Blastp_CBE
76.20
45%
-41
- C1 -
-
2CCH
5.8
-
CDK2_HUMAN
A:
[1-295]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
403
Blastp_CBE
76.16
45%
-47
- C1 -
-
4EOS
4.5
-
CDK2_HUMAN
A:
[3-297]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
---
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
453
Blastp_CBE
76.07
45%
-49
- C1 -
-
2UZB
6.4
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
424
Blastp_CBE
76.14
45%
-44
- C1 -
-
4CFV
6.9
-
CDK2_HUMAN
A:
[5-299]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
359
Blastp_CBE
76.07
45%
-48
- C1 -
-
1E9H
5.8
-
CDK2_HUMAN
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
391
Blastp_CBE
76.11
45%
-44
- C1 -
-
6GUB
7.3
-
CDK2_HUMAN
A:
[4-298]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
457
Blastp_CBE
76.10
45%
-39
- C1 -
-
2C6T
7.4
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
491
Blastp_CBE
76.01
41%
-19
- C1 -
-
6GU6
6.9
-
CDK1_HUMAN
A:
[6-294]
-----------------------------------
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
H
P
N
I
V
S
L
Q
D
V
L
----
M
Q
----
D
---------
S
--------
R
-
L
Y
L
I
F
E
F
L
S
M
D
L
-----
K
K
Y
L
D
S
---
I
-
P
PG
Q
Y
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
D
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
-------
T
H
----
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
-
T
K
K
P
L
F
H
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
L
Q
D
Y
K
-
N
T
-
F
-
P
K
---
W
K
P
-
G
S
L
-
A
S
-
H
V
K
N
------
L
D
E
N
--
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
D
-------------------------------------
364
Blastp_CBE
76.08
45%
-38
- C1 -
-
3DOG
8.1
-
CDK2_HUMAN
A:
[1-295]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
240
Blastp_CBE
76.07
45%
-50
- C1 -
-
2BHH
6.3
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
-----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
408
Blastp_CBE
76.05
45%
-41
- C1 -
-
4BCO
7.3
-
CDK2_HUMAN
A:
[2-296]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
474
Blastp_CBE
76.01
45%
-47
- C1 -
-
4EOK
6.7
-
CDK2_HUMAN
A:
[3-297]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
KDFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
441
Blastp_CBE
75.94
45%
-41
- C1 -
-
4EOP
6.3
-
CDK2_HUMAN
A:
[3-297]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
475
Blastp_CBE
75.93
45%
-40
- C1 -
-
4EON
5.7
-
CDK2_HUMAN
C:
[2-296]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
409
Blastp_CBE
75.84
45%
-42
- C1 -
-
4BCN
6.1
-
CDK2_HUMAN
C:
[2-296]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
414
Blastp_CBE
75.91
45%
-50
- C1 -
-
3TNW
4.7
-
CDK2_HUMAN
A:
[2-296]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
395
Blastp_CBE
75.89
45%
-43
- C1 -
-
1OIY
6.8
-
CDK2_HUMAN
A:
[4-298]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
432
Blastp_CBE
75.88
45%
-45
- C1 -
-
2IW6
7.2
-
CDK2_HUMAN
C:
[4-298]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KTFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
297
Blastp_CBE
75.87
45%
-47
- C1 -
-
1AQ1
8.9
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
---------------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
449
Blastp_CBE
75.79
45%
-40
- C1 -
-
2UZE
6.3
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
267
Blastp_CBE
75.84
45%
-58
- C1 -
-
1P2A
6.2
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
---
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
411
Blastp_CBE
75.82
45%
-52
- C1 -
-
4BCK
5.2
-
CDK2_HUMAN
C:
[2-296]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
460
Blastp_CBE
75.80
45%
-46
- C1 -
-
1JST
6.6
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
446
Blastp_CBE
75.79
45%
-41
- C1 -
-
2UZL
5.4
-
CDK2_HUMAN
C:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
352
Blastp_CBE
75.73
45%
-47
- C1 -
-
1H1Q
6.5
-
CDK2_HUMAN
A:
[5-299]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
376
Blastp_CBE
75.72
45%
-45
- C1 -
-
1QMZ
5.6
-
CDK2_HUMAN
A:
[1-295]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
413
Blastp_CBE
75.60
45%
-40
- C1 -
-
3TNW
4.8
-
CDK2_HUMAN
C:
[3-296]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
--
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
445
Blastp_CBE
75.52
45%
-41
- C1 -
-
4II5
5.8
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
345
Blastp_CBE
75.58
45%
-39
- C1 -
-
4CFM
6.6
-
CDK2_HUMAN
A:
[5-299]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
386
Blastp_CBE
75.51
45%
-45
- C1 -
-
6GUF
7.8
-
CDK2_HUMAN
A:
[4-298]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
340
Blastp_CBE
75.55
45%
-35
* C1 *
-
4CFX
6.3
-
CDK2_HUMAN
C:
[5-299]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
439
Blastp_CBE
75.52
45%
-45
- C1 -
-
4BCM
7.2
-
CDK2_HUMAN
A:
[3-297]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
120
Blastp_CBE
75.51
45%
-71
- C1 -
-
5FP5
3.0
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
-
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
-----------
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
------------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
416
Blastp_CBE
75.47
45%
-45
- C1 -
-
3MY5
4.8
-
CDK2_HUMAN
A:
[2-296]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
448
Blastp_CBE
75.43
45%
-39
- C1 -
-
2UZE
6.0
-
CDK2_HUMAN
C:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
384
Blastp_CBE
75.41
45%
-43
- C1 -
-
4EOI
5.6
-
CDK2_HUMAN
A:
[1-295]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KDFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
354
Blastp_CBE
75.39
45%
-41
- C1 -
-
1H1P
5.7
-
CDK2_HUMAN
A:
[5-299]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
198
Blastp_CBE
75.38
45%
-48
- C1 -
-
2VTN
4.0
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
------------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
356
Blastp_CBE
75.37
45%
-42
- C1 -
-
1PKD
8.4
-
CDK2_HUMAN
C:
[1-295]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
388
Blastp_CBE
75.32
45%
-46
- C1 -
-
6GUC
5.0
-
CDK2_HUMAN
C:
[4-298]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
451
Blastp_CBE
75.30
45%
-40
- C1 -
-
2UZD
5.9
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
393
Blastp_CBE
75.27
45%
-42
- C1 -
-
4CFN
4.8
-
CDK2_HUMAN
A:
[4-298]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
268
Blastp_CBE
75.16
45%
-75
- C1 -
-
1OIQ
5.9
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
----
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
-----------
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
------------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
420
Blastp_CBE
75.14
45%
-42
- C1 -
-
3BHU
6.5
-
CDK2_HUMAN
A:
[2-296]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
444
Blastp_CBE
75.12
45%
-41
- C1 -
-
4II5
5.5
-
CDK2_HUMAN
C:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
402
Blastp_CBE
75.07
45%
-39
- C1 -
-
4EOS
4.4
-
CDK2_HUMAN
C:
[3-297]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
390
Blastp_CBE
75.03
45%
-48
- C1 -
-
6GUB
7.5
-
?
C:
[4-298]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
--------
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
450
Blastp_CBE
75.01
45%
-47
- C1 -
-
2UZD
6.0
-
CDK2_HUMAN
C:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
465
Blastp_CBE
74.98
45%
-41
- C1 -
-
3QHR
6.8
-
CDK2_HUMAN
A:
[3-296]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
256
Blastp_CBE
74.88
45%
-53
- C1 -
-
1R78
7.2
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
------------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
442
Blastp_CBE
74.83
45%
-38
- C1 -
-
4I3Z
6.1
-
CDK2_HUMAN
C:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
371
Blastp_CBE
74.78
45%
-51
- C1 -
-
2CCI
5.3
-
CDK2_HUMAN
C:
[1-295]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
436
Blastp_CBE
74.70
45%
-44
- C1 -
-
4BCQ
5.7
-
CDK2_HUMAN
C:
[3-297]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
380
Blastp_CBE
74.67
45%
-43
- C1 -
-
1GY3
4.8
-
CDK2_HUMAN
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
373
Blastp_CBE
74.64
45%
-39
- C1 -
-
2CCH
6.3
-
CDK2_HUMAN
C:
[1-295]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
443
Blastp_CBE
74.60
45%
-40
- C1 -
-
4I3Z
6.0
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
343
Blastp_CBE
74.43
45%
-43
- C1 -
-
4CFW
6.9
-
CDK2_HUMAN
A:
[4-299]
---------------------------------
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
462
Blastp_CBE
74.39
45%
-43
- C1 -
-
3QHW
6.7
-
CDK2_HUMAN
C:
[3-296]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
464
Blastp_CBE
74.34
45%
-41
- C1 -
-
3QHR
6.6
-
CDK2_HUMAN
C:
[3-296]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
125
Blastp_CBE
74.31
45%
-67
- C1 -
-
5ANG
4.7
-
CDK2_HUMAN
A:
[2-294]
------------------------------------
E
N
F
Q
K
V
E
K
I
G
E
G
--
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
----------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
-----------
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
----------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
463
Blastp_CBE
74.29
45%
-43
- C1 -
-
3QHW
6.9
-
CDK2_HUMAN
A:
[3-296]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
461
Blastp_CBE
74.22
45%
-39
- C1 -
-
1FQ1
6.0
-
CDK2_HUMAN
B:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
319
Blastp_CBE
74.14
43%
-43
- C1 -
-
3NIZ
3.9
-
?
A:
[20-306]
-----------------------------------
M
E
K
Y
Q
K
L
E
K
V
G
E
G
T
Y
G
V
V
Y
K
A
K
D
S
Q
G
-
R
I
V
A
L
K
R
I
R
------
G
I
P
S
T
A
I
R
E
I
S
L
L
K
E
L
H
H
P
N
I
V
S
L
I
D
V
I
---------------
H
---
S
E
--------
R
C
L
T
L
V
F
E
F
M
E
K
D
L
-----
K
K
V
L
D
E
---
N
-
K
--
T
G
L
Q
D
S
Q
I
K
I
Y
L
Y
Q
L
L
R
G
V
A
H
C
H
Q
H
R
I
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
S
-
D
G
A
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
R
-------
H
----
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
S
V
D
I
W
S
I
G
C
I
F
A
E
M
I
-
T
G
K
P
L
F
P
G
V
T
-
D
-
D
D
Q
L
P
K
I
F
S
I
L
G
T
P
N
P
R
E
W
P
Q
V
Q
E
L
P
L
W
K
-
Q
R
-
T
-
F
Q
VFE
K
K
P
W
S
S
I
-----
I
P
G
------
F
C
Q
E
--
G
I
D
L
L
S
N
M
L
C
F
D
P
N
K
R
I
S
A
R
D
A
M
N
H
P
Y
F
K
D
-------------------------------------
515
Blastp_CBE
74.13
42%
-90
- C1 -
-
1UA2
6.2
-
CDK7_HUMAN
A:
[13-301]
---------------------------------------
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
K
N
T
N
Q
I
V
A
I
K
K
---------
I
N
R
T
A
L
R
E
I
K
L
L
Q
E
L
S
H
P
N
I
I
G
L
L
D
A
F
----------
G
----
H
---
K
S
--------
N
-
I
S
L
V
F
D
F
M
E
T
D
L
-----
E
V
I
I
K
D
---
N
-
S
--
L
V
L
T
P
S
H
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
--
D
E
-
N
G
V
L
K
L
A
D
F
G
L
A
K
S
F
G
S
P
N
R
----
A
Y
H
-----
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
-
L
R
V
P
F
L
P
G
D
S
-
D
-
L
D
Q
L
T
R
I
F
E
T
L
G
T
P
T
E
E
Q
W
P
D
M
C
S
L
P
--
D
-
Y
V
-
T
-
F
K
---
S
F
P
G
I
P
L
-
H
H
-
I
F
S
A
------
A
G
D
D
--
L
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
S
N
--
R
P
G
P
-------------------------------
387
Blastp_CBE
74.07
45%
-40
- C1 -
-
6GUE
7.2
-
CDK2_HUMAN
C:
[4-298]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
-----
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
---
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
389
Blastp_CBE
74.01
45%
-45
- C1 -
-
6GUC
5.7
-
CDK2_HUMAN
A:
[4-298]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
459
Blastp_CBE
73.64
45%
-45
- C1 -
-
1JST
5.5
-
CDK2_HUMAN
C:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
341
Blastp_CBE
73.52
45%
-41
- C1 -
-
4CFX
6.1
-
CDK2_HUMAN
A:
[5-299]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
437
Blastp_CBE
73.29
45%
-47
- C1 -
-
4BCQ
5.2
-
CDK2_HUMAN
A:
[3-297]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
-----
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
477
Blastp_CBE
73.26
45%
-49
- C1 -
-
4EOJ
4.7
-
CDK2_HUMAN
C:
[4-298]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
KDFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
------------------------
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
360
Blastp_CBE
72.99
45%
-41
- C1 -
-
6GVA
7.7
-
CDK2_HUMAN
A:
[2-291]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
----------------------------------
121
Blastp_CBE
72.74
45%
-51
- C1 -
-
5D1J
6.6
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
--------------
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
-------------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
514
Blastp_CBE
72.55
42%
-83
- C1 -
-
1UA2
6.2
-
CDK7_HUMAN
B:
[13-301]
---------------------------------------
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
K
N
T
N
Q
I
V
A
I
K
K
---------
I
N
R
T
A
L
R
E
I
K
L
L
Q
E
L
S
H
P
N
I
I
G
L
L
D
A
F
----------
G
----
H
---
K
S
--------
N
-
I
S
L
V
F
D
F
M
E
T
D
L
-----
E
V
I
I
K
D
---
N
-
S
--
L
V
L
T
P
S
H
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
--
D
E
-
N
G
V
L
K
L
A
D
F
G
L
A
K
S
F
G
S
P
N
R
----
A
Y
H
-----
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
-
L
R
V
P
F
L
P
G
D
S
-
D
-
L
D
Q
L
T
R
I
F
E
T
L
G
T
P
T
E
E
Q
W
P
D
M
C
S
L
P
--
D
-
Y
V
-
T
-
F
K
---
S
F
P
G
I
P
L
-
H
H
-
I
F
S
A
------
A
G
D
D
--
L
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
S
N
--
R
P
G
P
-------------------------------
417
Blastp_CBE
72.35
45%
-54
- C1 -
-
3BHV
6.6
-
CDK2_HUMAN
C:
[2-296]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
----------------------------------
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
513
Blastp_CBE
72.14
42%
-84
- C1 -
-
1UA2
5.4
-
CDK7_HUMAN
C:
[13-301]
---------------------------------------
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
K
N
T
N
Q
I
V
A
I
K
K
---------
I
N
R
T
A
L
R
E
I
K
L
L
Q
E
L
S
H
P
N
I
I
G
L
L
D
A
F
----------
G
----
H
---
K
S
--------
N
-
I
S
L
V
F
D
F
M
E
T
D
L
-----
E
V
I
I
K
D
---
N
-
S
--
L
V
L
T
P
S
H
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
--
D
E
-
N
G
V
L
K
L
A
D
F
G
L
A
K
S
F
G
S
P
N
R
----
A
Y
H
-----
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
-
L
R
V
P
F
L
P
G
D
S
-
D
-
L
D
Q
L
T
R
I
F
E
T
L
G
T
P
T
E
E
Q
W
P
D
M
C
S
L
P
--
D
-
Y
V
-
T
-
F
K
---
S
F
P
G
I
P
L
-
H
H
-
I
F
S
A
------
A
G
D
D
--
L
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
S
N
--
R
P
G
P
-------------------------------
400
Blastp_CBE
71.98
45%
-51
- C1 -
-
1OGU
6.0
-
CDK2_HUMAN
C:
[4-298]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
----------------------------------
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
407
Blastp_CBE
71.91
45%
-48
- C1 -
-
4BCO
7.2
-
CDK2_HUMAN
C:
[2-296]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
-----------------------------------
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
150
Blastp_CBE
71.35
45%
-49
- C1 -
-
4D1Z
5.4
-
CDK2_HUMAN
A:
[3-294]
-------------------------------------
N
F
Q
K
V
E
K
I
G
----
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
------------
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
----------K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
-------------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
421
Blastp_CBE
71.30
45%
-53
- C1 -
-
3BHT
6.3
-
CDK2_HUMAN
C:
[2-296]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
----------------------------------
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
425
Blastp_CBE
71.22
45%
-50
- C1 -
-
4CFU
6.7
-
CDK2_HUMAN
C:
[5-299]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
----------------------------------
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
489
Blastp_CBE
71.17
41%
-14
- C1 -
-
4NST
6.0
-
CDK12_HUMAN
A:
[10-326]
---------------------------------
R
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
K
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
H
R
S
V
V
N
M
K
E
I
V
----
T
D
----
K
----
Q
---
D
-G-------
A
-
F
Y
L
V
F
E
Y
M
D
H
D
L
-----
M
G
L
L
E
S
---
G
-
L
--
V
H
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
--
N
N
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
S
E
E
S
----
R
P
Y
N
----
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
-
T
K
K
P
I
F
Q
A
N
L
-
E
-
L
A
Q
L
E
L
I
S
R
L
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
-
T
M
-
K
-
P
K
---
K
Q
Y
R
R
R
L
-
R
E
-
E
F
S
F
------
I
P
S
A
--
A
L
D
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
T
L
Q
S
D
F
L
K
D
--
V
E
L
--
S
K
M
A
P
P
D
L
P
H
W
Q
D
-----------------
419
Blastp_CBE
71.09
45%
-48
- C1 -
-
3BHU
6.8
-
CDK2_HUMAN
C:
[2-296]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
----------------------------------
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
488
Blastp_CBE
71.02
41%
-17
- C1 -
-
4NST
5.7
-
C:
[10-326]
---------------------------------
R
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
K
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
H
R
S
V
V
N
M
K
E
I
V
----
T
D
---------------KG------
A
-
F
Y
L
V
F
E
Y
M
D
H
D
L
-----
M
G
L
L
E
S
---
G
-
L
--
V
H
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
--
N
N
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
S
-
E
S
----
R
P
Y
N
----
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
-
T
K
K
P
I
F
Q
A
N
L
-
E
-
L
A
Q
L
E
L
I
S
R
L
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
-
T
M
-
K
-
P
K
---
K
Q
Y
R
R
R
L
-
R
E
-
E
F
S
F
------
I
P
S
A
--
A
L
D
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
T
L
Q
S
D
F
L
K
D
--
V
E
L
--
S
K
M
A
P
P
D
L
P
H
W
Q
D
-----------------
481
Blastp_CBE
70.85
41%
-8
- C1 -
-
4CXA
6.1
-
CDK12_HUMAN
A:
[10-326]
---------------------------------
R
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
K
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
H
R
S
V
V
N
M
K
E
I
V
----
T
D
----
K
----
Q
-----LDFKKDKG
A
-
F
Y
L
V
F
E
Y
M
D
H
D
L
-----
M
G
L
L
E
S
---
G
-
L
--
V
H
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
--
N
N
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
S
E
E
-----
R
P
Y
N
----
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
-
T
K
K
P
I
F
Q
A
N
L
-
E
-
L
A
Q
L
E
L
I
S
R
L
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
-
T
M
-
K
-
P
K
---
K
Q
Y
R
R
R
L
-
R
E
-
E
F
S
F
------
I
P
S
A
--
A
L
D
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
T
L
Q
S
D
F
L
K
D
--
V
E
L
--
S
K
M
A
P
P
D
L
P
H
W
Q
D
-----------------
519
Blastp_CBE
70.75
41%
-22
- C1 -
-
4BCI
5.8
-
CDK9_HUMAN
A:
[14-324]
--------------------------------
C
D
E
V
S
K
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
RT------------------
G
--------
S
-
I
Y
L
V
F
D
F
C
E
H
D
L
-----
A
G
L
L
S
N
---
V
-
L
--
V
K
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
--
T
R
-
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
-
A
--------
P
NRYN
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
-
T
R
S
P
I
M
Q
G
N
T
-
E
-
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
-
K
L
-
E
-
L
V
---
K
G
Q
K
R
K
V
-
K
D
-
R
L
K
A
------
Y
V
R
D
PY
A
L
D
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
S
--
D
P
M
P
S
D
-----------------------------
523
Blastp_CBE
70.67
41%
-21
- C1 -
-
3TN8
3.6
-
CDK9_HUMAN
A:
[14-324]
--------------------------------
C
D
E
V
S
K
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
RT------------------
G
--------
S
-
I
Y
L
V
F
D
F
C
E
H
D
L
-----
A
G
L
L
S
N
---
V
-
L
--
V
K
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
--
T
R
-
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
---------
Q
P
NRYN
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
-
T
R
S
P
I
M
Q
G
N
T
-
E
-
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
-
K
L
-
E
-
L
V
---
K
G
Q
K
R
K
V
-
K
D
-
R
L
K
A
------
Y
V
R
D
PY
A
L
D
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
S
--
D
P
M
P
S
D
-----------------------------
326
Blastp_CBE
70.55
45%
-60
- C1 -
-
2R3N
7.9
-
CDK2_HUMAN
A:
[2-295]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
369
Blastp_CBE
70.30
45%
-44
- C1 -
-
2G9X
6.5
-
CDK2_HUMAN
C:
[1-295]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-------------------------------
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
557
HHSearch
70.24
34%
-20
- C1 -
-
4ZSG
2.3
-
MK07_HUMAN
A:
[5-309]
----------------------------------
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
G
Q
Q
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
----
R
P
TVPY
G
----
E
---
F
K
--------
S
-
V
Y
V
V
L
D
L
M
E
S
D
L
-----
H
Q
I
I
H
S
---
S
----
Q
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
--
N
E
-
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
EHQY
F
M
T
E
----
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
-
A
R
R
Q
L
F
P
G
K
N
-
Y
-
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
V
I
Q
A
V
G
A
E
R
V
R
A
Y
I
Q
-
S
-
L
P
---
P
R
Q
P
V
P
W
-
E
T
-
V
Y
P
G
------
A
D
R
Q
--
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
--
Y
H
D
P
D
D
-----------------------------
553
HHSearch
70.20
33%
-31
- C1 -
-
4IC7
5.0
-
MK07_HUMAN
A:
[53-354]
----------------------------------
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
G
Q
Q
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
----
R
P
----
T
VPYG
E
---
F
K
--------
S
-
V
Y
V
V
L
D
L
M
E
S
D
L
-----
H
Q
I
I
H
S
---
S
----
Q
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
--
N
E
-
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
EHQY
F
M
T
E
----
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
-
A
R
R
Q
L
F
P
G
K
N
-
Y
-
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
V
I
Q
A
V
G
A
E
R
V
R
A
-
Y
I
-
Q
S
L
P
---
P
R
Q
P
V
P
W
-
E
T
-
V
Y
P
G
------
A
D
R
Q
--
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
--
Y
H
D
--------------------------------
482
Blastp_CBE
70.10
41%
-24
- C1 -
-
5EFQ
6.0
-
C:
[8-315]
---------------------------------
R
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
R
D
K
D
T
G
E
M
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
T
H
Q
S
I
I
N
M
K
E
I
V
----
T
D
----
K
----
E
-----G-------
A
-
F
Y
L
V
F
E
Y
M
D
H
D
L
-----
M
G
L
L
E
S
---
G
-
L
--
V
H
F
N
E
N
H
I
K
S
F
M
R
Q
L
M
E
G
L
D
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
--
N
N
-
R
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
S
S
E
E
S
----
R
P
Y
N
----
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
-
T
K
K
P
I
F
Q
A
N
Q
-
E
-
L
A
Q
L
E
L
I
S
R
I
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
-
T
M
-
K
-
P
K
---
K
Q
Y
R
R
K
L
-
R
E
-
E
F
V
F
------
I
P
A
A
--
A
L
D
L
F
D
Y
M
L
A
L
D
P
S
K
R
C
T
A
E
Q
A
L
Q
C
E
F
L
R
D
------
V
E
P
S
K
M
P
------------------------
524
Blastp_CBE
70.08
41%
-30
- C1 -
-
3MY1
4.7
-
CDK9_HUMAN
A:
[14-324]
--------------------------------
C
D
E
V
S
K
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
RTK----------------
K
G
--------
S
-
I
Y
L
V
F
D
F
C
E
H
D
L
-----
A
G
L
L
S
N
---
V
-
L
--
V
K
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
--
T
R
-
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
-
A
K
----
N
S
Q
P
NRYN
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
-
T
R
S
P
I
M
Q
G
N
T
-
E
-
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
-
K
L
-
E
-
L
V
---
K
G
Q
K
R
K
V
-
K
D
-
R
L
K
A
------
Y
V
R
D
PY
A
L
D
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
S
--
D
P
M
P
S
D
-----------------------------
521
Blastp_CBE
70.06
41%
-22
- C1 -
-
4BCG
6.0
-
CDK9_HUMAN
A:
[14-324]
--------------------------------
C
D
E
V
S
K
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
RT-----------------
K
G
--------
S
-
I
Y
L
V
F
D
F
C
E
H
D
L
-----
A
G
L
L
S
N
---
V
-
L
--
V
K
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
--
T
R
-
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
-
A
K
----
N
S
Q
P
NRYN
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
-
T
R
S
P
I
M
Q
G
N
T
-
E
-
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
-
K
L
-
E
-
L
V
---
K
G
Q
K
R
K
V
-
K
D
-
R
L
K
A
------
Y
V
R
D
PY
A
L
D
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
S
--
D
P
M
P
S
D
-----------------------------
480
Blastp_CBE
70.05
41%
-0
- C1 -
-
5ACB
8.7
-
CDK12_HUMAN
C:
[10-326]
---------------------------------
R
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
K
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
H
R
S
V
V
N
M
K
E
I
V
----
T
D
----
K
----
Q
---
D
A
LDFKKDKG
A
-
F
Y
L
V
F
E
Y
M
D
H
D
L
-----
M
G
L
L
E
S
---
G
-
L
--
V
H
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
--
N
N
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
S
E
E
S
----
R
P
Y
N
----
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
-
T
K
K
P
I
F
Q
A
N
L
-
E
-
L
A
Q
L
E
L
I
S
R
L
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
-
T
M
-
K
-
P
K
---
K
Q
Y
R
R
R
L
-
R
E
-
E
F
S
F
------
I
P
S
A
--
A
L
D
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
T
L
Q
S
D
F
L
K
D
--
V
E
L
--
S
K
M
A
P
P
D
L
P
H
W
Q
D
-----------------
430
Blastp_CBE
70.01
45%
-46
- C1 -
-
2IW9
7.0
-
CDK2_HUMAN
C:
[4-298]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KTFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-------------------------------------
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
516
Blastp_CBE
69.81
41%
-24
- C1 -
-
4BCF
4.0
-
CDK9_HUMAN
A:
[14-324]
--------------------------------
C
D
E
V
S
K
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
RT-----------------
K
A
--------
S
-
I
Y
L
V
F
D
F
C
E
H
D
L
-----
A
G
L
L
S
N
---
V
-
L
--
V
K
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
--
T
R
-
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
----------
P
NRYN
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
-
T
R
S
P
I
M
Q
G
N
T
-
E
-
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
-
K
L
-
E
-
L
V
---
K
G
Q
K
R
K
V
-
K
D
-
R
L
K
A
------
Y
V
R
D
PY
A
L
D
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
S
--
D
P
M
P
S
D
-----------------------------
434
Blastp_CBE
69.89
45%
-44
- C1 -
-
4EOQ
5.5
-
CDK2_HUMAN
C:
[4-298]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
-------------------------------
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
483
Blastp_CBE
69.85
41%
-23
- C1 -
-
5EFQ
5.8
-
CDK13_HUMAN
A:
[8-315]
---------------------------------
R
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
R
D
K
D
T
G
E
M
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
T
H
Q
S
I
I
N
M
K
E
I
V
----
T
D
----
K
----
E
-----G-------
A
-
F
Y
L
V
F
E
Y
M
D
H
D
L
-----
M
G
L
L
E
S
---
G
-
L
--
V
H
F
N
E
N
H
I
K
S
F
M
R
Q
L
M
E
G
L
D
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
--
N
N
-
R
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
S
S
E
E
S
----
R
P
Y
N
----
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
-
T
K
K
P
I
F
Q
A
N
Q
-
E
-
L
A
Q
L
E
L
I
S
R
I
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
-
T
M
-
K
-
P
K
---
K
Q
Y
R
R
K
L
-
R
E
-
E
F
V
F
------
I
P
A
A
--
A
L
D
L
F
D
Y
M
L
A
L
D
P
S
K
R
C
T
A
E
Q
A
L
Q
C
E
F
L
R
D
------
V
E
P
S
K
M
P
------------------------
381
Blastp_CBE
69.82
45%
-46
- C1 -
-
4EOR
7.4
-
CDK2_HUMAN
C:
[1-295]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-------------------------------
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
479
Blastp_CBE
69.81
41%
4
- C1 -
-
5ACB
6.6
-
D:
[10-326]
---------------------------------
R
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
K
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
H
R
S
V
V
N
M
K
E
I
V
----
T
D
----
K
----
Q
-----FKKDKG--
A
-
F
Y
L
V
F
E
Y
M
D
H
D
L
-----
M
G
L
L
E
S
---
G
-
L
--
V
H
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
--
N
N
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
---
S
----
R
P
Y
N
----
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
-
T
K
K
P
I
F
Q
A
N
L
-
E
-
L
A
Q
L
E
L
I
S
R
L
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
-
T
M
-
K
-
P
K
---
K
Q
Y
R
R
R
L
-
R
E
-
E
F
S
F
------
I
P
S
A
--
A
L
D
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
T
L
Q
S
D
F
L
K
D
--
V
E
L
--
S
K
M
A
P
P
D
L
P
H
W
Q
D
-----------------
469
Blastp_CBE
69.78
45%
-41
- C1 -
-
4EOM
6.6
-
CDK2_HUMAN
C:
[4-298]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
-------------------------------
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
558
HHSearch
69.40
34%
-17
- C1 -
-
5BYZ
8.2
-
MK07_HUMAN
A:
[4-308]
----------------------------------
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
G
Q
Q
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
----
R
P
TVPY
G
----
E
---
F
K
--------
S
-
V
Y
V
V
L
D
L
M
E
S
D
L
-----
H
Q
I
I
H
S
---
S
----
Q
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
--
N
E
-
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
EHQY
F
M
T
E
----
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
-
A
R
R
Q
L
F
P
G
K
N
-
Y
-
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
V
I
Q
A
V
G
A
E
R
V
R
A
-
Y
I
Q
S
-
L
P
---
P
R
Q
P
V
P
W
-
E
T
-
V
Y
P
G
------
A
D
R
Q
--
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
--
Y
H
D
P
D
D
-----------------------------
405
Blastp_CBE
69.39
45%
-48
- C1 -
-
4BCP
6.3
-
CDK2_HUMAN
C:
[2-296]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
---
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
----------------------------------
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
487
Blastp_CBE
69.20
41%
-42
- C1 -
-
6CKX
6.6
-
CDK12_HUMAN
A:
[10-312]
---------------------------------
R
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
K
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
H
R
S
V
V
N
M
K
E
I
V
----
T
----------------DKG-----
A
-
F
Y
L
V
F
E
Y
M
D
H
D
L
-----
M
G
L
L
E
S
---
G
-
L
--
V
H
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
--
N
N
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
S
E
E
S
----
R
P
Y
N
----
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
-
T
K
K
P
I
F
Q
A
N
L
-
E
-
L
A
Q
L
E
L
I
S
R
L
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
-
T
M
-
K
-
P
K
---
K
Q
Y
R
R
R
L
-
R
E
-
E
F
S
F
------
I
P
S
A
--
A
L
D
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
T
L
Q
S
D
F
L
K
D
--
V
E
L
--------------------------------
485
Blastp_CBE
69.16
42%
-22
- C1 -
-
6B3E
8.0
-
CDK12_HUMAN
A:
[6-309]
---------------------------------
R
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
K
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
H
R
S
V
V
N
M
K
E
I
V
----
T
D
---------------KG------
A
-
F
Y
L
V
F
E
Y
M
D
H
D
L
-----
M
G
L
L
E
S
---
G
-
L
--
V
H
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
--
N
N
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
S
E
E
S
----
R
P
Y
N
----
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
-
T
K
K
P
I
F
Q
A
N
L
-
E
-
L
A
Q
L
E
L
I
S
R
L
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
-
T
M
-
K
-
P
K
---
K
Q
Y
R
R
R
L
-
R
E
-
E
F
S
F
------
I
P
S
A
--
A
L
D
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
T
L
Q
S
D
F
L
K
D
--
V
E
L
--------------------------------
486
Blastp_CBE
68.94
41%
-41
- C1 -
-
6CKX
6.4
-
C:
[10-312]
---------------------------------
R
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
K
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
H
R
S
V
V
N
M
K
E
I
V
----
T
----------------DKG-----
A
-
F
Y
L
V
F
E
Y
M
D
H
D
L
-----
M
G
L
L
E
S
---
G
-
L
--
V
H
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
--
N
N
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
S
E
E
S
----
R
P
Y
N
----
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
-
T
K
K
P
I
F
Q
A
N
L
-
E
-
L
A
Q
L
E
L
I
S
R
L
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
-
T
M
-
K
-
P
K
---
K
Q
Y
R
R
R
L
-
R
E
-
E
F
S
F
------
I
P
S
A
--
A
L
D
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
T
L
Q
S
D
F
L
K
D
--
V
E
L
--------------------------------
396
Blastp_CBE
68.90
45%
-50
- C1 -
-
1OIU
7.4
-
CDK2_HUMAN
C:
[4-298]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
----------------------------------------
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
415
Blastp_CBE
68.78
45%
-54
- C1 -
-
3MY5
4.4
-
CDK2_HUMAN
C:
[2-296]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
---------------------------------------
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
520
Blastp_CBE
68.70
41%
-11
- C1 -
-
4BCH
5.2
-
CDK9_HUMAN
A:
[14-324]
--------------------------------
C
D
E
V
S
K
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
RTKA----------------
G
--------
S
-
I
Y
L
V
F
D
F
C
E
H
D
L
-----
A
G
L
L
S
N
---
V
-
L
--
V
K
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
--
T
R
-
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
----------
P
NRYN
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
-
T
R
S
P
I
M
Q
G
N
T
-
E
-
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
-
K
L
-
E
-
L
V
---
K
G
Q
K
R
K
V
-
K
D
-
R
L
K
A
------
Y
V
R
D
PY
A
L
D
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
S
--
D
P
M
P
S
D
-----------------------------
355
Blastp_CBE
68.61
45%
-51
- C1 -
-
5LMK
8.2
-
?
C:
[1-295]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
----------------------------------------
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
525
Blastp_CBE
68.49
41%
-25
- C1 -
-
3LQ5
5.8
-
CDK9_HUMAN
A:
[14-324]
--------------------------------
C
D
E
V
S
K
Y
E
K
L
A
K
I
G
Q
--
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
RT-----------------
K
G
--------
S
-
I
Y
L
V
F
D
F
C
E
H
D
L
-----
A
G
L
L
S
N
---
V
-
L
--
V
K
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
--
T
R
-
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
-
A
--------
P
NRYN
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
-
T
R
S
P
I
M
Q
G
N
T
-
E
-
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
-
K
L
-
E
-
L
V
---
K
G
Q
K
R
K
V
-
K
D
-
R
L
K
A
------
Y
V
R
D
PY
A
L
D
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
S
--
D
P
M
P
S
D
-----------------------------
484
Blastp_CBE
68.48
42%
-23
- C1 -
-
6B3E
8.9
-
C:
[6-309]
---------------------------------
R
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
K
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
H
R
S
V
V
N
M
K
E
I
V
----
T
D
---------------KG------
A
-
F
Y
L
V
F
E
Y
M
D
H
D
L
-----
M
G
L
L
E
S
---
G
-
L
--
V
H
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
--
N
N
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
S
E
E
S
----
R
P
Y
N
----
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
-
T
K
K
P
I
F
Q
A
N
L
-
E
-
L
A
Q
L
E
L
I
S
R
L
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
-
T
M
-
K
-
P
K
---
K
Q
Y
R
R
R
L
-
R
E
-
E
F
S
F
------
I
P
S
A
--
A
L
D
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
T
L
Q
S
D
F
L
K
D
--
V
E
L
--------------------------------
518
Blastp_CBE
68.18
41%
-25
- C1 -
-
4BCJ
5.6
-
CDK9_HUMAN
A:
[14-324]
--------------------------------
C
D
E
V
S
K
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
RTK----------------
K
G
--------
S
-
I
Y
L
V
F
D
F
C
E
H
D
L
-----
A
G
L
L
S
N
---
V
-
L
--
V
K
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
--
T
R
-
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
-
A
--------
P
NRYN
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
-
T
R
S
P
I
M
Q
G
N
T
-
E
-
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
-
K
L
-
E
-
L
V
---
K
G
Q
K
R
K
V
-
K
D
-
R
L
K
A
------
Y
V
R
D
PY
A
L
D
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
S
--
D
P
M
P
S
D
-----------------------------
334
Blastp_CBE
67.94
45%
-46
- C1 -
-
2IW8
7.2
-
CDK2_HUMAN
C:
[4-298]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
H
V
D
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
----------------------------------------
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
365
Blastp_CBE
67.61
45%
-48
- C1 -
-
3DDQ
7.8
-
CDK2_HUMAN
C:
[1-295]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
----------------------------------------
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
423
Blastp_CBE
67.51
45%
-54
- C1 -
-
4CFV
7.4
-
CDK2_HUMAN
C:
[5-299]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
---------------------------------------
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
526
Blastp_CBE
67.36
41%
-30
- C1 -
-
3BLR
6.9
-
CDK9_HUMAN
A:
[14-324]
--------------------------------
C
D
E
V
S
K
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
RT---------------------------
S
-
I
Y
L
V
F
D
F
C
E
H
D
L
-----
A
G
L
L
S
N
---
V
-
L
--
V
K
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
--
T
R
-
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
-
A
--------
P
NRYN
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
-
T
R
S
P
I
M
Q
G
N
T
-
E
-
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
-
K
L
-
E
-
L
V
---
K
-----
V
-
K
D
-
R
L
K
A
------
Y
V
R
D
PY
A
L
D
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
S
--
D
P
M
P
S
D
-----------------------------
363
Blastp_CBE
67.18
45%
-49
- C1 -
-
3DOG
8.2
-
CDK2_HUMAN
C:
[1-295]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
---------------------------------------
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
344
Blastp_CBE
66.68
45%
-42
- C1 -
-
4CFM
6.6
-
CDK2_HUMAN
C:
[5-299]
----------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
-----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
---------------------------------------
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
527
Blastp_CBE
65.50
41%
-28
- C1 -
-
3BLQ
4.6
-
CDK9_HUMAN
A:
[14-324]
--------------------------------
C
D
E
V
S
K
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
RT---------------------------
S
-
I
Y
L
V
F
D
F
C
E
H
D
L
-----
A
G
L
L
S
N
---
V
-
L
--
V
K
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
--
T
R
-
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
------------NRYN
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
-
T
R
S
P
I
M
Q
G
N
T
-
E
-
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
-
K
L
-
E
-
L
V
---
K
-------
K
D
-
R
L
K
A
------
Y
V
R
D
PY
A
L
D
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
S
--
D
P
M
P
S
D
-----------------------------
568
HHSearch
65.22
31%
-39
- C1 -
-
4NM3
3.6
-
GSK3B_HUMAN
A:
[53-345]
-----------------------------------
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
K
------
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
----
Y
S
----
S
-----KKD
E
V
--------
Y
-
L
N
L
V
L
D
Y
V
P
E
T
V
-----
Y
R
V
A
R
H
YSR
A
-
K
--
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
--
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
-----
P
N
V
S
----
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
-
L
G
Q
P
I
F
P
G
D
S
-
G
-
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
--
Y
T
-
E
F
-
K
-
F
P
---
Q
I
K
A
H
P
W
T
K
V
-
F
R
P
R
------
T
P
P
E
--
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
--
L
R
D
--------------------------------
522
Blastp_CBE
64.01
41%
-35
- C1 -
-
3TNH
4.1
-
CDK9_HUMAN
A:
[14-324]
--------------------------------
C
D
E
V
S
K
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
RT---------------------------
S
-
I
Y
L
V
F
D
F
C
E
H
D
L
-----
A
G
L
L
S
N
---
V
-
L
--
V
K
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
--
T
R
-
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
------------NRYN
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
-
T
R
S
P
I
M
Q
G
N
T
-
E
-
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
N
Y
---------------------
V
-
K
D
-
R
L
K
A
------
Y
V
R
D
PY
A
L
D
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
S
--
D
P
M
P
S
D
-----------------------------
468
Blastp_CBE
60.72
45%
-26
- C1 -
-
1H01
3.8
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
-
I
R
------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
467
Blastp_CBE
60.17
45%
-26
- C1 -
-
1OIR
5.1
-
CDK2_HUMAN
A:
[1-294]
-----------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
-
I
R
------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
---------------
H
---
T
E
--------
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
KKFMD
A
S
A
L
T
G
---
I
-
P
--
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
-
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
--
K
P
-
S
-
F
P
---
K
W
A
R
Q
D
F
-
S
K
-
V
V
P
P
------
L
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-------------------------------
-
* C *
-
:
--------------------------------------------------------------------