@TOME V3
(Feb 2022)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CSKP_HUMAN: (2020-09-07 )
MADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKGKYKMNPRQWSHISESAKDLVRRMLMLDPAERITVYEALNHPWLKERDRYAYKIHLPETVEQLRKFNARRKLKGAVLAAVSSHKFNSFYGDPPEELPDFSEDPTSSGLLAAERAVSQVLDSLEEIHALTDCSEKDLDFLHSVFQDQHLHTLLDLYDKINTKSSPQIRNPPSDAVQRAKEVLEEISCYPENNDAKELKRILTQPHFMALLQTHDVVAHEVYSDEALRVTPPPTSPYLNGDSPESANGDMDMENVTRVRLVQFQKNTDEPMGITLKMNELNHCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCERDSPSTSRQSPANGHSSTNNSVSDLPSTTQPKGRQIYVRAQFEYDPAKDDLIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLENSKNGTAGLIPSPELQEWRVACIAMEKTKQEQQASCTWFGKKKKQYKDKYLAKHNAVFDQLDLVTYEEVVKLPAFKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFVSHDQMMQDISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAPTITPGLNEDESLQRLQKESDILQRTYAHYFDLTIINNEIDETIRHLEEAVELVCTAPQWVPVSWVY
Atome Classification :
(51 SA)
.........10........20........30........40........50.-.......60-.....--....70---.........80........90........100.......110.......120.......130.......140.......150..-....-..160.......-170.....---..180.......190-..------.......200.......210.......--220---.-..-..-...230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAD
D
D
V
L
F
E
D
V
Y
E
L
C
E
V
IGKG
P
F
S
V
V
R
R
C
I
N
R
ET
G
Q
Q
F
A
V
K
I
V
D
V
A
K
FTSSP-GL
S
T
E
D
L
K
--
R
E
A
S
I
--
C
H
M
LK----H
P
H
I
V
E
L
L
E
T
YSSD
G
M
L
Y
M
V
F
E
FMD
G
A
D
L
C
F
E
I
V
K
RADAG
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
HDNNIIHRDVKP
H
C
V
L
L
AS-KE-NSA
P
-
V
K
LG
G
F
G
V
A
I
Q
L-GESGLVAG---GRVGTPHFMA
P
E
V
---
V
K------REPYGKPVDV
W
G
C
G
V
I
L
F
I
L
L
SGCLPF--YG----
T
-
K
E
-
R
L
-
F
E
G
I
IKGKYKM
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
MLDPA
E
R
I
T
V
Y
E
ALNH
P
W
L
K
ERD
R
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
L
K
G
A
V
L
A
A
V
SSHKFNSFYGD
P
P
E
ELPDFSEDPTSS
G
L
L
A
A
E
R
A
V
S
Q
V
L
D
S
L
E
E
I
H
A
LTDCSEK
D
L
D
F
L
H
S
V
F
QD
Q
H
L
H
T
L
L
D
L
Y
D
KINTKSSPQIRNP
P
S
D
A
V
Q
R
A
K
E
V
L
E
E
ISCYPENN
D
A
K
E
L
K
R
I
LT
Q
P
H
F
M
A
L
L
Q
T
H
D
V
V
A
H
EVYSDE
A
L
R
VTPPPTSPYLNGDSPESANGDM
D
M
E
N
V
T
R
V
R
L
V
Q
F
QKNTDEP
M
G
I
T
L
K
M
N
E
L
N
H
C
I
V
A
R
I
M
HG
G
M
I
HRQG
T
L
HVGD
E
I
R
EINGI
S
V
A
N
Q
T
V
E
Q
L
Q
K
M
L
R
E
MRG
S
I
T
F
K
I
VPSYRTQSSSCERDSPSTSRQSPANGHSSTNNSVSDLPSTTQPKG
R
Q
I
Y
V
R
A
Q
F
EYDPAKDDLI
P
C
K
EA
G
I
R
F
R
V
G
D
I
I
Q
I
I
SKDDHNWWQGKLENSKNGTAGLIPS
P
E
L
Q
E
W
R
V
A
C
I
A
M
E
KT
K
Q
E
Q
QASCTWFG
K
K
K
K
Q
Y
K
D
K
Y
L
A
K
H
N
A
V
F
D
Q
L
D
L
V
T
Y
E
E
V
V
KLPAFK
R
K
T
L
V
L
L
GAHGV
G
R
R
H
I
K
N
T
LITKHPDRFAYPIPHTTRPPKKDEENGK
N
Y
Y
F
V
S
H
D
Q
M
M
Q
D
ISNNE
Y
L
EYGSHEDAMYG
T
K
L
E
T
I
R
K
I
H
EQG
L
I
A
I
L
DV
E
P
Q
A
L
K
V
L
R
TAEFA
P
F
V
V
F
I
AAPTITPGLN
E
D
E
S
L
Q
R
L
Q
K
E
S
D
I
L
Q
R
T
Y
A
H
Y
F
D
L
T
I
IN
N
E
I
D
E
T
I
R
H
L
E
E
A
V
E
L
VCTAPQ
W
V
PVSWVY
1
PsiBlast_PDB
95.73
100%
-141
- C4 -
-
3TAC
-
CSKP_HUMAN
A:
[17-332]
M
A
D
D
D
V
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
P
-
G
L
S
T
E
D
L
K
--
R
E
A
S
I
--
C
H
M
L
K
----
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
-
K
E
-
N
S
A
P
-
V
K
L
G
G
F
G
V
A
I
Q
L
-
G
E
S
G
L
V
A
G
---
G
R
V
G
T
P
H
F
M
A
P
E
V
---
V
K
------
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
--
Y
G
----
T
-
K
E
-
R
L
-
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
R
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
L
K
G
A
V
L
A
A
V
S
S
H
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
535
HHSearch
94.89
100%
-140
- C4 -
-
3C0G
1
CSKP_HUMAN
B:
[19-338]
----
D
V
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
P
-
G
L
S
T
E
D
L
K
--
R
E
A
S
I
--
C
H
M
L
K
----
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
-
K
E
-
N
S
A
P
-
V
K
L
G
G
F
G
V
A
I
Q
L
-
G
E
S
G
L
V
A
G
---
G
R
V
G
T
P
H
F
M
A
P
E
V
---
V
K
------
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
--
Y
G
----
T
-
K
E
-
R
L
-
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
R
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
L
K
G
A
V
L
A
A
V
S
S
H
K
F
N
S
F
Y
G
D
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Blastp_CBE
94.89
100%
-140
- C4 -
-
3C0G
1
CSKP_HUMAN
B:
[19-338]
----
D
V
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
P
-
G
L
S
T
E
D
L
K
--
R
E
A
S
I
--
C
H
M
L
K
----
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
-
K
E
-
N
S
A
P
-
V
K
L
G
G
F
G
V
A
I
Q
L
-
G
E
S
G
L
V
A
G
---
G
R
V
G
T
P
H
F
M
A
P
E
V
---
V
K
------
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
--
Y
G
----
T
-
K
E
-
R
L
-
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
R
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
L
K
G
A
V
L
A
A
V
S
S
H
K
F
N
S
F
Y
G
D
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
94.77
100%
-150
- C4 -
-
3C0G
1
CSKP_HUMAN
A:
[20-336]
-----
V
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
P
-
G
L
S
T
E
D
L
K
--
R
E
A
S
I
--
C
H
M
L
K
----
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
-
K
E
-
N
S
A
P
-
V
K
L
G
G
F
G
V
A
I
Q
L
-
G
E
S
G
L
V
A
G
---
G
R
V
G
T
P
H
F
M
A
P
E
V
---
V
K
------
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
--
Y
G
----
T
-
K
E
-
R
L
-
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
R
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
L
K
--
V
L
A
A
V
------
S
F
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
94.29
100%
-160
- C4 -
-
3C0H
1
CSKP_HUMAN
A:
[19-318]
----
D
V
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
P
-
G
L
S
T
E
D
L
K
--
R
E
A
S
I
--
C
H
M
L
K
----
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
-
K
E
-
N
S
A
P
-
V
K
L
G
G
F
G
V
A
I
Q
L
-
G
E
S
G
L
V
A
G
---
G
R
V
G
T
P
H
F
M
A
P
E
V
---
V
K
------
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
--
Y
G
----
T
-
K
E
-
R
L
-
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
R
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Blastp_CBE
94.10
100%
-153
- C4 -
-
3C0H
1
CSKP_HUMAN
B:
[19-318]
----
D
V
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
P
-
G
L
S
T
E
D
L
K
--
R
E
A
S
I
--
C
H
M
L
K
----
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
-
K
E
-
N
S
A
P
-
V
K
L
G
G
F
G
V
A
I
Q
L
-
G
E
S
G
L
V
A
G
---
G
R
V
G
T
P
H
F
M
A
P
E
V
---
V
K
------
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
--
Y
G
----
T
-
K
E
-
R
L
-
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
R
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
536
HHSearch
92.33
100%
-153
- C4 -
-
3C0I
1
CSKP_HUMAN
A:
[20-317]
-----
V
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
P
-
G
L
S
T
E
D
L
K
--
R
E
A
S
I
--
C
H
M
L
K
----
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
-
K
E
-
N
S
A
P
-
V
K
L
G
G
F
G
V
A
I
Q
L
-
G
E
S
G
L
V
A
G
---
G
R
V
G
T
P
H
F
M
A
P
E
V
---
V
K
------
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
--
Y
G
----
T
-
K
E
-
R
L
-
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
R
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
92.33
100%
-153
- C4 -
-
3C0I
1
CSKP_HUMAN
A:
[20-317]
-----
V
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
P
-
G
L
S
T
E
D
L
K
--
R
E
A
S
I
--
C
H
M
L
K
----
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
-
K
E
-
N
S
A
P
-
V
K
L
G
G
F
G
V
A
I
Q
L
-
G
E
S
G
L
V
A
G
---
G
R
V
G
T
P
H
F
M
A
P
E
V
---
V
K
------
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
--
Y
G
----
T
-
K
E
-
R
L
-
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
R
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
92.25
98%
-144
- C4 -
-
3MFU
1
CSKP_HUMAN
A:
[19-320]
----
D
V
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
P
-
G
L
S
T
E
D
L
K
--
R
E
A
S
I
--
C
H
M
L
K
----
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
V
L
L
A
S
-
K
E
-
N
S
A
P
-
V
K
L
G
D
F
G
V
A
I
Q
L
-
G
E
S
G
L
V
A
G
---
G
R
V
G
T
P
H
F
M
A
P
E
V
---
V
K
------
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
--
Y
G
----
T
-
K
E
-
R
L
-
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
R
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
L
K
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
92.21
98%
-144
- C4 -
-
3MFR
1
CSKP_HUMAN
A:
[19-320]
----
D
V
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
P
-
G
L
S
T
E
D
L
K
--
R
E
A
S
I
--
C
H
M
L
K
----
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
V
L
L
A
S
-
K
E
-
N
S
A
P
-
V
K
L
G
D
F
G
V
A
I
Q
L
-
G
E
S
G
L
V
A
G
---
G
R
V
G
T
P
H
F
M
A
P
E
V
---
V
K
------
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
--
Y
G
----
T
-
K
E
-
R
L
-
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
R
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
L
K
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
92.00
98%
-146
- C4 -
-
3MFS
1
CSKP_HUMAN
A:
[18-320]
---
D
D
V
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
P
-
G
L
S
T
E
D
L
K
--
R
E
A
S
I
--
C
H
M
L
K
----
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
V
L
L
A
S
-
K
E
-
N
S
A
P
-
V
K
L
G
D
F
G
V
A
I
Q
L
-
G
E
S
G
L
V
A
G
---
G
R
V
G
T
P
H
F
M
A
P
E
V
---
V
K
------
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
--
Y
G
----
T
-
K
E
-
R
L
-
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
R
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
L
K
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
90.68
98%
-145
- C- -
-
3MFT
-
CSKP_HUMAN
A:
[5-306]
----
D
V
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
P
-
G
L
S
T
E
D
L
K
--
R
E
A
S
I
--
C
H
M
L
K
----
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
V
L
L
A
S
-
K
E
-
N
S
A
P
-
V
K
L
G
D
F
G
V
A
I
Q
L
-
G
E
S
G
L
V
A
G
---
G
R
V
G
T
P
H
F
M
A
P
E
V
---
V
K
------
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
--
Y
G
----
T
-
K
E
-
R
L
-
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
R
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
L
K
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
73.50
46%
-112
- C4 -
-
2V7O
3
KCC2G_HUMAN
A:
[29-321]
-------
F
T
D
D
Y
Q
L
F
E
E
L
G
K
G
-
F
S
V
V
R
R
C
V
K
K
T
P
T
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
R
----
D
H
Q
K
L
E
--
R
E
A
R
I
--
C
R
L
L
K
----
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
H
Q
I
L
E
S
V
N
H
I
H
Q
H
D
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
-
K
C
-
K
G
A
A
-
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
G
E
Q
Q
A
W
F
---
G
F
A
G
T
P
G
Y
L
S
P
E
V
---
L
R
------
K
D
P
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
D
----
E
-
D
Q
H
K
L
-
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
D
Q
A
L
K
H
P
W
V
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
E
C
L
R
K
F
N
A
R
R
K
L
K
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
73.45
45%
-113
- C4 -
-
2VZ6
2
KCC2A_HUMAN
A:
[18-310]
-----
L
Y
F
Q
S
M
Y
Q
L
F
E
E
L
G
K
--
F
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
R
----
D
H
Q
K
L
E
--
R
E
A
R
I
--
C
R
L
L
K
----
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
H
H
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
-
K
L
-
K
G
A
A
-
V
K
L
A
D
F
G
L
A
I
E
V
-
E
G
E
Q
Q
A
W
F
---
G
F
A
G
T
P
G
Y
L
S
P
E
V
---
L
R
------
K
D
P
Y
G
K
P
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
D
----
E
D
Q
H
-
R
L
-
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
A
A
E
A
L
K
H
P
W
I
S
H
R
S
T
V
A
S
C
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
73.28
42%
-103
- C4 -
-
2BDW
-
KCC2D_CAEEL
A:
[5-315]
----
S
T
K
F
S
D
N
Y
D
V
K
E
E
L
G
K
G
A
F
S
V
V
R
R
C
V
H
K
T
T
G
L
E
F
A
A
K
I
I
N
T
K
K
L
S
A
R
----
D
F
Q
K
L
E
--
R
E
A
R
I
--
C
R
K
L
Q
----
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
S
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
F
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
I
A
Y
C
H
S
N
G
I
V
H
R
N
L
K
P
E
N
L
L
L
A
S
-
K
A
-
K
G
A
A
-
V
K
L
A
D
F
G
L
A
I
E
V
-
N
D
S
E
-
A
W
H
---
G
F
A
G
T
P
G
Y
L
S
P
E
V
---
L
K
------
K
D
P
Y
S
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
D
----
E
-
D
Q
H
R
L
-
Y
A
Q
I
K
A
G
A
Y
D
Y
P
S
P
E
W
D
T
V
T
P
E
A
K
S
L
I
D
S
M
L
T
V
N
P
K
K
R
I
T
A
D
Q
A
L
K
V
P
W
I
C
N
R
E
R
V
A
S
A
I
H
R
Q
D
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
I
A
T
R
N
L
S
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
73.25
46%
-109
- C4 -
-
5U6Y
-
KCC2A_RAT
A:
[1-298]
----------
M
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
R
----
D
H
Q
K
L
E
--
R
E
A
R
I
--
C
R
L
L
K
----
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
H
H
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
-
K
L
-
K
G
A
A
-
V
K
L
A
D
F
G
L
A
I
E
V
-
E
G
E
Q
Q
A
W
F
---
G
F
A
G
T
P
G
Y
L
S
P
E
V
---
L
R
------
K
D
P
Y
G
K
P
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
D
----
E
D
Q
H
-
R
L
-
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
A
A
E
A
L
K
H
P
W
I
S
H
R
S
T
V
A
S
C
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
Blastp_CBE
73.24
47%
-117
- C4 -
-
3BHH
1
KCC2B_HUMAN
B:
[4-293]
---------
D
E
Y
Q
L
Y
E
D
I
G
K
---
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
R
----
D
H
Q
K
L
E
--
R
E
A
R
I
--
C
R
L
L
K
----
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
-
K
C
-
K
G
A
A
-
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
G
D
Q
Q
A
W
F
---
G
F
A
G
T
P
G
Y
L
S
P
E
V
---
L
R
------
K
E
A
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
D
----
E
D
Q
H
-
K
L
-
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
H
E
A
L
K
H
P
W
V
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
E
C
L
K
K
F
N
A
R
R
K
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
73.23
47%
-117
- C4 -
-
3BHH
1
KCC2B_HUMAN
A:
[4-293]
---------
D
E
Y
Q
L
Y
E
D
I
G
----
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
R
----
D
H
Q
K
L
E
--
R
E
A
R
I
--
C
R
L
L
K
----
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
-
K
C
-
K
G
A
A
-
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
G
D
Q
Q
A
W
F
---
G
F
A
G
T
P
G
Y
L
S
P
E
V
---
L
R
------
K
E
A
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
D
----
E
D
Q
H
-
K
L
-
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
H
E
A
L
K
H
P
W
V
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
E
C
L
K
K
F
N
A
R
R
K
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Blastp_CBE
72.87
45%
-112
- C4 -
-
2VZ6
3
KCC2A_HUMAN
B:
[18-311]
-----
L
Y
F
Q
S
M
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
R
----
D
H
Q
K
L
E
--
R
E
A
R
I
--
C
R
L
L
K
----
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
H
H
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
-
K
L
-
K
G
A
A
-
V
K
L
A
D
F
G
L
A
I
E
V
-
E
G
E
Q
Q
A
W
F
---
G
F
A
G
T
P
G
Y
L
S
P
E
V
---
L
R
------
K
D
P
Y
G
K
P
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
D
----
E
D
Q
H
-
R
L
-
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
A
A
E
A
L
K
H
P
W
I
S
H
R
S
T
V
A
S
C
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Blastp_CBE
72.79
48%
-109
- C4 -
-
6AYW
2
KCC2D_HUMAN
B:
[11-300]
-------
F
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
R
----
D
H
Q
K
L
E
--
R
E
A
R
I
--
C
R
L
L
K
----
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
-
K
S
-
K
G
A
A
-
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
G
D
Q
Q
A
W
F
---
G
F
A
G
T
P
G
Y
L
S
P
E
V
---
L
R
------
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
D
----
E
-
D
Q
H
R
L
-
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
543
HHSearch
72.72
48%
-129
- C4 -
-
2WEL
7
KCC2D_HUMAN
A:
[2-303]
-------
M
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
----
A
R
D
H
Q
K
L
E
--
R
E
A
R
I
--
C
R
L
L
K
----
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
----
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
-
K
S
-
K
G
A
A
-
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
G
D
Q
Q
A
W
F
---
G
F
A
G
T
P
G
Y
L
S
P
E
V
---
L
R
------
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
D
----
E
-
D
Q
H
R
L
-
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
----
S
M
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
L
A
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Blastp_CBE
72.67
48%
-108
- C4 -
-
5VLO
2
KCC2D_HUMAN
B:
[11-300]
-------
F
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
R
----
D
H
Q
K
L
E
--
R
E
A
R
I
--
C
R
L
L
K
----
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
-
K
S
-
K
G
A
A
-
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
G
D
Q
Q
A
W
F
---
G
F
A
G
T
P
G
Y
L
S
P
E
V
---
L
R
------
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
D
----
E
-
D
Q
H
R
L
-
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Blastp_CBE
72.49
48%
-108
- C4 -
-
6BAB
1
KCC2D_MOUSE
D:
[10-301]
--------
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
R
----
D
H
Q
K
L
E
--
R
E
A
R
I
--
C
R
L
L
K
----
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
-
K
S
-
K
G
A
A
-
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
G
D
Q
Q
A
W
F
---
G
F
A
G
T
P
G
Y
L
S
P
E
V
---
L
R
------
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
D
----
E
-
D
Q
H
R
L
-
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
72.39
47%
-127
- C4 -
-
2WEL
7
KCC2D_HUMAN
A:
[4-300]
---------
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
R
----
D
H
Q
K
L
E
--
R
E
A
R
I
--
C
R
L
L
K
----
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
-
K
S
-
K
G
A
A
-
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
G
D
Q
Q
A
W
F
---
G
F
A
G
T
P
G
Y
L
S
P
E
V
---
L
R
------
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
D
----
E
-
D
Q
H
R
L
-
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
----
S
M
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
72.27
47%
-111
- C4 -
-
5VLO
2
KCC2D_HUMAN
A:
[11-301]
-------
F
T
D
E
Y
Q
L
F
E
E
L
G
---
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
R
----
D
H
Q
K
L
E
--
R
E
A
R
I
--
C
R
L
L
K
----
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
-
K
S
-
K
G
A
A
-
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
G
D
Q
Q
A
W
F
---
G
F
A
G
T
P
G
Y
L
S
P
E
V
---
L
R
------
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
D
----
E
-
D
Q
H
R
L
-
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
72.21
47%
-107
- C4 -
-
2VN9
2
KCC2D_HUMAN
A:
[4-300]
---------
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
R
----
D
H
Q
K
L
E
--
R
E
A
R
I
--
C
R
L
L
K
----
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
-
K
S
-
K
G
A
A
-
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
G
D
Q
Q
A
W
F
---
G
F
A
G
T
P
G
Y
L
S
P
E
V
---
L
R
------
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
D
----
E
-
D
Q
H
R
L
-
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Blastp_CBE
72.08
48%
-104
- C4 -
-
2VN9
1
KCC2D_HUMAN
B:
[4-300]
---------
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
R
----
D
H
Q
K
L
E
--
R
E
A
R
I
--
C
R
L
L
K
----
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
-
K
S
-
K
G
A
A
-
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
G
D
Q
Q
A
W
F
---
G
F
A
G
T
P
G
Y
L
S
P
E
V
---
L
R
------
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
D
----
E
-
D
Q
H
R
L
-
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Blastp_CBE
71.73
48%
-112
- C4 -
-
6BAB
2
KCC2D_MOUSE
B:
[14-302]
----------
E
Y
Q
L
F
E
E
L
G
----
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
R
----
D
H
Q
K
L
E
--
R
E
A
R
I
--
C
R
L
L
K
----
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
-
K
S
-
K
G
A
A
-
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
G
D
Q
Q
A
W
F
---
G
F
A
G
T
P
G
Y
L
S
P
E
V
---
L
R
------
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
D
----
E
-
D
Q
H
R
L
-
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Blastp_CBE
71.61
48%
-108
- C4 -
-
6BAB
3
KCC2D_MOUSE
C:
[14-301]
----------
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
----
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
R
----
D
H
Q
K
L
E
--
R
E
A
R
I
--
C
R
L
L
K
----
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
-
K
S
-
K
G
A
A
-
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
G
D
Q
Q
A
W
F
---
G
F
A
G
T
P
G
Y
L
S
P
E
V
---
L
R
------
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
D
----
E
-
D
Q
H
R
L
-
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
71.15
47%
-111
- C4 -
-
6AYW
2
KCC2D_HUMAN
A:
[11-301]
-------
F
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
R
----
D
H
Q
K
L
E
--
R
E
A
R
I
--
C
R
L
L
K
----
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
-
K
S
-
K
G
A
A
-
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
G
D
Q
Q
A
W
F
---
G
F
A
G
T
P
G
Y
L
S
P
E
V
---
L
R
------
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
D
----
E
-
D
Q
H
R
L
-
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
70.58
47%
-104
- C4 -
-
6BAB
2
KCC2D_MOUSE
A:
[12-301]
--------
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
R
----
D
H
Q
K
L
E
--
R
E
A
R
I
--
C
R
L
L
K
----
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
-
K
S
-
K
G
A
A
-
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
G
D
Q
Q
A
W
F
---
G
F
A
G
T
P
G
Y
L
S
P
E
V
---
L
R
------
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
D
----
E
-
D
Q
H
R
L
-
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
70.29
45%
-99
- C4 -
-
3SOA
1
KCC2A_HUMAN
A:
[9-307]
-------
F
T
E
E
Y
Q
L
F
E
E
L
G
K
G
--
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
M
I
I
N
T
K
K
L
S
A
R
----
D
H
Q
K
L
E
--
R
E
A
R
I
--
C
R
L
L
K
----
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
H
H
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
N
L
K
P
E
N
L
L
L
A
S
-
K
L
-
K
G
A
A
-
V
K
L
A
D
F
G
L
A
I
E
V
-
E
G
E
Q
Q
A
W
F
---
G
F
A
G
T
P
G
Y
L
S
P
E
V
---
L
R
------
K
D
P
Y
G
K
P
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
D
----
E
D
Q
H
-
R
L
-
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
A
A
E
A
L
K
H
P
W
I
S
H
R
S
T
V
A
S
C
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
V
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
Blastp_CBE
69.07
44%
-123
- C4 -
-
5FG8
3
KCC2A_DROME
A:
[12-277]
-------
F
S
D
N
Y
D
I
K
E
E
L
G
K
G
A
F
S
I
V
K
R
C
V
Q
K
S
T
G
F
E
F
A
A
K
I
I
N
T
K
K
L
T
A
R
----
D
F
Q
K
L
E
--
R
E
A
R
I
--
C
R
K
L
H
----
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
N
Y
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
F
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
N
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
-
K
A
-
K
G
A
A
-
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
G
D
H
Q
A
W
F
---
G
F
A
G
T
P
G
Y
L
S
P
E
V
---
L
K
------
K
E
P
Y
G
K
S
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
D
----
E
D
Q
H
-
R
L
-
Y
S
Q
I
K
A
G
A
Y
D
Y
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
V
N
P
N
K
R
I
T
A
A
E
A
L
K
H
P
W
I
C
Q
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Blastp_CBE
67.86
44%
-117
- C4 -
-
5H9B
2
KCC2A_DROME
A:
[12-277]
-------
F
S
D
N
Y
D
I
K
E
E
L
G
K
G
A
F
S
I
V
K
R
C
V
Q
K
S
T
G
F
E
F
A
A
K
I
I
N
T
K
K
L
T
A
R
----
D
F
Q
K
L
E
--
R
E
A
R
I
--
C
R
K
L
H
----
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
N
Y
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
F
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
N
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
-
K
A
-
K
G
A
A
-
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
G
D
H
Q
A
W
F
---
G
F
A
G
T
P
G
Y
L
S
P
E
V
---
L
K
------
K
E
P
Y
G
K
S
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
D
----
E
D
Q
H
-
R
L
-
Y
S
Q
I
K
A
G
A
Y
D
Y
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
V
N
P
N
K
R
I
T
A
A
E
A
L
K
H
P
W
I
C
Q
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
Blastp_CBE
67.68
44%
-123
- C4 -
-
5HU3
1
KCC2A_DROME
A:
[12-274]
-------
F
S
D
N
Y
D
I
K
E
E
L
G
K
G
A
F
S
I
V
K
R
C
V
Q
K
S
T
G
F
E
F
A
A
K
I
I
N
T
K
K
L
T
A
R
----
D
F
Q
K
L
E
--
R
E
A
R
I
--
C
R
K
L
H
----
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
N
Y
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
F
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
N
G
V
V
H
R
N
L
K
P
E
N
L
L
L
A
S
-
K
A
-
K
G
A
A
-
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
G
D
H
Q
A
W
F
---
G
F
A
G
T
P
G
Y
L
S
P
E
V
---
L
K
------
K
E
P
Y
G
K
S
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
D
----
E
D
Q
H
-
R
L
-
Y
S
Q
I
K
A
G
A
Y
D
Y
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
V
N
P
N
K
R
I
T
A
A
E
A
L
K
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
262
Blastp_CBE
61.47
35%
-102
- C4 -
-
5JZN
1
B:
[21-279]
-----------
Y
K
V
G
R
T
I
G
D
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
I
K
K
S
K
C
R
G
K
E
-
H
M
----
I
Q
--
N
E
V
S
I
--
L
R
R
V
K
----
H
P
N
I
V
L
L
I
E
E
M
D
V
P
T
E
L
Y
L
V
M
E
L
V
K
G
G
D
L
-
F
D
A
I
T
S
T
N
K
---
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
L
L
V
Y
E
H
Q
D
-
G
S
K
S
-
L
K
L
G
D
F
G
L
A
T
-------
I
V
D
G
PLY
T
V
C
G
T
P
T
Y
V
A
P
E
I
---
I
A
------
E
T
G
Y
G
L
K
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
--
R
G
----
S
-
Q
E
-
V
L
-
F
D
Q
I
L
M
G
Q
V
D
F
P
S
P
Y
W
D
N
V
S
D
S
A
K
E
L
I
T
M
M
L
L
V
D
V
D
Q
R
F
S
A
V
Q
V
L
E
H
P
W
V
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
263
Blastp_CBE
60.86
35%
-89
- C4 -
-
5JZN
1
DCLK1_HUMAN
A:
[21-279]
-----------
Y
K
V
G
R
T
I
G
D
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
I
K
K
S
K
C
R
G
K
E
-
H
M
----
I
Q
--
N
E
V
S
I
--
L
R
R
V
K
----
H
P
N
I
V
L
L
I
E
E
M
D
V
P
T
E
L
Y
L
V
M
E
L
V
K
G
G
D
L
-
F
D
A
I
T
S
T
N
K
---
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
L
L
V
Y
E
H
Q
D
-
G
S
K
S
-
L
K
L
G
D
F
G
L
A
T
-------
I
V
D
G
PLY
T
V
C
G
T
P
T
Y
V
A
P
E
I
---
I
A
------
E
T
G
Y
G
L
K
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
--
R
G
----
S
D
Q
E
-
V
L
-
F
D
Q
I
L
M
G
Q
V
D
F
P
S
P
Y
W
D
N
V
S
D
S
A
K
E
L
I
T
M
M
L
L
V
D
V
D
Q
R
F
S
A
V
Q
V
L
E
H
P
W
V
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
265
Blastp_CBE
60.55
35%
-105
- C4 -
-
5JZJ
2
DCLK1_HUMAN
A:
[38-296]
-----------
Y
K
V
G
R
T
I
G
D
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
I
K
K
S
K
C
R
G
K
E
-
H
M
----
I
Q
--
N
E
V
S
I
--
L
R
R
V
K
----
H
P
N
I
V
L
L
I
E
E
M
D
V
P
T
E
L
Y
L
V
M
E
L
V
K
G
G
D
L
-
F
D
A
I
T
S
T
N
K
---
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
L
L
V
Y
E
H
Q
D
-
G
S
K
S
-
L
K
L
G
D
F
G
L
A
T
-------
I
V
D
G
PLY
T
V
C
G
T
P
T
Y
V
A
P
E
I
---
I
A
------
E
T
G
Y
G
L
K
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
--
R
G
----
S
--
E
-
V
L
-
F
D
Q
I
L
M
G
Q
V
D
F
P
S
P
Y
W
D
N
V
S
D
S
A
K
E
L
I
T
M
M
L
L
V
D
V
D
Q
R
F
S
A
V
Q
V
L
E
H
P
W
V
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
264
Blastp_CBE
60.44
35%
-106
- C4 -
-
5JZJ
1
B:
[38-296]
-----------
Y
K
V
G
R
T
I
G
D
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
I
K
K
S
K
C
R
G
K
E
-
H
M
----
I
Q
--
N
E
V
S
I
--
L
R
R
V
K
----
H
P
N
I
V
L
L
I
E
E
M
D
V
P
T
E
L
Y
L
V
M
E
L
V
K
G
G
D
L
-
F
D
A
I
T
S
T
N
K
---
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
L
L
V
Y
E
H
Q
D
-
G
S
K
S
-
L
K
L
G
D
F
G
L
A
T
-------
I
V
D
G
PLY
T
V
C
G
T
P
T
Y
V
A
P
E
I
---
I
A
------
E
T
G
Y
G
L
K
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
--
R
--------
E
-
V
L
-
F
D
Q
I
L
M
G
Q
V
D
F
P
S
P
Y
W
D
N
V
S
D
S
A
K
E
L
I
T
M
M
L
L
V
D
V
D
Q
R
F
S
A
V
Q
V
L
E
H
P
W
V
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
259
Blastp_CBE
58.43
34%
-72
- C4 -
-
5O1S
2
A:
[39-336]
----
S
I
Q
F
T
D
G
Y
E
V
K
E
D
I
-----
S
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
D
K
S
K
--
R
D
P
-
T
E
E
I
E
I
L
L
--
R
Y
G
--------
Q
----
H
P
N
I
I
T
L
K
D
V
Y
D
D
G
K
Y
V
Y
V
V
T
E
L
M
K
G
G
E
L
L
D
K
I
L
R
Q
K
----
F
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
-
E
S
G
N
P
E
S
-
I
R
I
C
D
F
G
F
A
K
Q
L
R
A
E
N
G
L
L
M
T
----
P
C
---
N
F
V
A
P
E
V
---
L
E
------
R
Q
G
Y
D
A
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
--
A
N
GPDD
T
-
P
E
-
E
I
-
L
A
R
I
G
S
G
K
F
S
L
S
G
G
Y
W
N
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
A
A
L
V
L
R
H
P
W
I
V
H
W
D
Q
------
L
P
Q
Y
--
Q
L
N
R
Q
D
A
P
H
L
V
K
G
A
M
A
A
T
Y
S
A
L
N
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
118
Blastp_CBE
56.93
36%
-52
- C4 -
-
5A6O
2
DAPK3_HUMAN
B:
[2-270]
------
M
V
E
D
H
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
K
R
R
L
S
S
S
R
R
G
V
S
R
E
E
I
E
--
R
E
V
N
I
--
L
R
E
I
R
----
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
-
F
D
F
L
A
E
K
E
S
---
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
-
K
N
-
V
P
N
P
R
I
K
L
I
D
F
G
I
A
H
K
I
--
E
-----
K
---
N
I
F
G
T
P
E
F
V
A
P
E
I
---
V
N
------
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
G
E---
T
-
K
Q
-
E
T
-
L
T
N
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
A
Q
S
L
E
H
S
W
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
247
Blastp_CBE
56.55
37%
-106
- C4 -
-
2WTJ
5
CHK2_HUMAN
A:
[14-288]
-------
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------
P
-
A
L
N
V
E
T
-----
E
I
E
I
--
L
K
K
L
N
----
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
-
E
D
C
L
-
I
K
I
T
D
F
G
H
S
K
I
L
--
E
T
S
L
M
R
T
----
L
C
G
T
P
T
Y
L
A
P
E
V
LVS
V
G
------
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
SE
H
R
----
T
-
Q
V
-
S
L
-
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
120
Blastp_CBE
56.38
36%
-53
- C4 -
-
5A6N
1
DAPK3_HUMAN
B:
[2-270]
------
M
V
E
D
H
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
K
R
R
L
S
S
S
R
R
G
V
S
R
E
E
I
E
--
R
E
V
N
I
--
L
R
E
I
R
----
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
-
F
D
F
L
A
E
K
E
S
---
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
-
K
N
-
V
P
N
P
R
I
K
L
I
D
F
G
I
A
H
K
I
--
E
-----
K
---
N
I
F
G
T
P
E
F
V
A
P
E
I
---
V
N
------
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
G
E---
T
-
K
Q
-
E
T
-
L
T
N
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
A
Q
S
L
E
H
S
W
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
282
Blastp_CBE
55.54
34%
-131
- C4 -
-
5XZV
1
RAD53_YEAST
A:
[162-465]
V
A
N
K
T
G
I
F
K
D
F
S
I
I
D
E
V
V
G
Q
G
A
F
A
T
V
K
K
A
I
E
R
T
T
G
K
T
F
A
V
K
I
I
S
K
R
K
V
I
G
N
-----
M
D
G
V
T
--
R
E
L
E
V
--
L
Q
K
L
N
----
H
P
R
I
V
R
L
K
G
F
Y
E
D
T
E
S
Y
Y
M
V
M
E
F
V
S
G
G
D
L
M
D
F
V
A
A
H
G
A
V
G
----
E
D
A
G
R
E
I
S
R
Q
I
L
T
A
I
K
Y
I
H
S
M
G
I
S
H
R
D
L
K
P
D
N
I
L
I
-
E
-
Q
D
-
D
P
V
L
-
V
K
I
T
D
F
G
L
A
K
-------------------
L
A
Y
V
A
P
E
V
---
I
--------
N
E
Y
S
S
L
V
D
M
W
S
M
G
C
L
V
Y
V
I
L
T
G
H
L
P
F
----S---
T
-
Q
D
-
Q
L
-
Y
K
Q
I
G
R
G
S
-----
L
K
D
F
R
I
S
E
E
A
R
D
F
I
D
S
L
---
D
P
N
N
--
T
A
A
K
A
L
N
H
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129
Blastp_CBE
54.32
38%
-14
- C4 -
-
2Y7J
1
PHKG2_HUMAN
B:
[92-364]
-------
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
----
T
A
----
S
P
E
Q
L
E
EV
R
E
A
T
R
RE
T
H
I
L
R
QVAG
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
----
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
----
D
-
D
N
M
Q
-
I
R
L
S
D
F
G
F
S
C
H
L
--
E
P
G
E
K
L
R
---
E
L
C
G
T
P
G
Y
L
A
P
E
I
---
L
K
CSMDET
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
--
W
H
----
R
-
R
Q
-
I
L
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
130
Blastp_CBE
54.16
38%
-13
- C4 -
-
2Y7J
1
PHKG2_HUMAN
A:
[92-364]
-------
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
----
T
A
E
-
R
L
S
P
E
Q
L
E
EV
R
E
A
T
R
RE
T
H
I
L
R
QVAG
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
----
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
----
D
-
D
N
M
Q
-
I
R
L
S
D
F
G
F
S
C
H
L
--
E
P
G
E
K
L
R
---
E
L
C
G
T
P
G
Y
L
A
P
E
I
---
L
K
CSMDET
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
--
W
H
----
R
-
R
Q
-
I
L
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
128
Blastp_CBE
54.12
38%
-16
- C4 -
-
2Y7J
1
PHKG2_HUMAN
C:
[92-364]
-------
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
----
T
A
E
-
R
L
S
P
E
Q
L
E
EV
R
E
A
T
R
RE
T
H
I
L
R
QVAG
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
----
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
----
D
-
D
N
M
Q
-
I
R
L
S
D
F
G
F
S
C
H
L
--
E
P
G
E
K
L
R
---
E
L
C
G
T
P
G
Y
L
A
P
E
I
---
L
K
CSMDET
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
--
W
H
----
R
-
R
Q
-
I
L
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
277
Blastp_CBE
53.84
34%
-128
- C4 -
-
4PDS
1
RAD53_YEAST
A:
[26-305]
----
T
G
I
F
K
D
F
S
I
I
D
E
V
-------
T
V
K
K
A
I
E
R
T
T
G
K
T
F
S
V
K
I
I
----------------
V
T
--
R
E
L
E
V
--
L
Q
K
L
N
----
H
P
R
I
V
R
L
K
G
F
Y
---
E
S
Y
Y
M
V
M
E
F
V
S
G
G
D
L
M
D
F
V
A
A
H
G
A
V
G
----
E
D
A
G
R
E
I
S
R
Q
I
L
T
A
I
K
Y
I
H
S
M
G
I
S
H
R
D
L
K
P
D
N
I
L
I
-
E
-
Q
D
-
D
P
V
L
-
V
K
I
T
A
F
G
L
A
K
V
-------------------
A
Y
V
A
P
E
V
---
I
R
------
R
N
E
Y
S
S
L
V
D
M
W
S
M
G
C
L
V
Y
V
I
L
T
G
H
L
P
F
--
S
G
S---
T
-
Q
D
-
Q
L
-
Y
K
Q
I
G
R
G
S
Y
H
E
G
P
L
K
D
F
R
I
S
E
E
A
R
D
F
I
D
S
L
L
Q
V
D
P
N
N
R
S
T
A
A
K
A
L
N
H
P
W
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
274
Blastp_CBE
53.40
36%
-9
- C4 -
-
2PHK
2
PHKG1_RABIT
A:
[2-276]
-------
F
Y
E
N
Y
E
P
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
D
V
---
T
G
G
G
-
S
F
S
A
E
E
V
Q
EL
R
E
A
T
L
KE
V
D
I
L
R
KVSG
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
K
V
----
T
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
-
D
M
-
N
----
I
K
L
T
D
F
G
F
S
C
Q
L
--
D
P
G
E
K
L
R
---
E
V
C
G
T
P
S
Y
L
A
P
E
I
---
I
E
CSMNDN
H
P
G
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
--
W
H
----
R
-
K
Q
-
M
L
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
A
E
E
A
L
A
H
P
F
F
Q
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
273
Blastp_CBE
53.04
36%
-9
- C4 -
-
1QL6
1
PHKG1_RABIT
A:
[15-289]
-------
F
Y
E
N
Y
E
P
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
D
V
---
T
G
G
G
-
S
F
S
A
E
E
V
Q
EL
R
E
A
T
L
KE
V
D
I
L
R
KVSG
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
K
V
----
T
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
-
D
M
-
N
----
I
K
L
T
D
F
G
F
S
C
Q
L
--
D
P
G
E
K
L
R
---
S
V
C
G
T
P
S
Y
L
A
P
E
I
---
I
E
CSMNDN
H
P
G
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
--
W
H
----
R
-
K
Q
-
M
L
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
A
E
E
A
L
A
H
P
F
F
Q
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
275
Blastp_CBE
52.56
36%
-8
- C4 -
-
1PHK
1
PHKG1_RABIT
A:
[15-289]
-------
F
Y
E
N
Y
E
P
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
D
V
---
T
G
G
G
-
S
F
S
A
E
E
V
Q
EL
R
E
A
T
L
KE
V
D
I
L
R
KVSG
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
K
V
----
T
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
-
D
M
-
N
----
I
K
L
T
D
F
G
F
S
C
Q
L
--
D
P
G
E
K
L
R
---
E
V
C
G
T
P
S
Y
L
A
P
E
I
---
I
E
CSMNDN
H
P
G
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
--
W
H
----
R
-
K
Q
-
M
L
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
A
E
E
A
L
A
H
P
F
F
Q
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------