@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SGK1_HUMAN: (2020-09-21 )
MTVKTEAAKGTLTYSRMRGMVAILIAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL
Atome Classification :
(433 SA)
--------------------------------------------------------------.........10........20...-.....30........--40........50........60........70........80.----.......90...-.....100.....-..110.......---120-.---.-.......130....-.-..140.......150..-.......160.......170.......180.......190.........200.......210...-....220.......230.-......240..-.--.-...250....--..-..260.......270-----.---......280.......290..-....----.300----..----.....-310-...----..--.-----..320.......330......--.340-.--.--.-....--.350.......---360.......370.......380....--...390.-.......400.......410.......420.----......430
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--------------------------------------------------------------MTVKTEAAKGT
L
T
Y
S
R
M
R
G
M
V
A
I
L
-
I
A
F
M
K
Q
RRM
G
L
N
D
F
I
--
Q
K
IANNSYACK
H
P
E
V
Q
S
I
L
K
ISQPQEPELMNANPSPPPSPSQ
Q
----
I
NLGPSSNPHAK-PSD
F
H
F
L
K
V
IGKG-SF
G
K
V
L
L
A
R
H
K
A
---
E
---
E
---
V
-
F
Y
A
V
K
V
L
Q
K
K
A
I
L
K
-
K
-
K
E
E
K
H
I
M
S
E
R
N
V
L
--
L
K
-NVKH
P
F
L
V
G
L
H
F
S
FQTA
D
K
L
Y
F
V
L
D
YING
G
E
L
F
Y
H
L
Q
R
--
E
R
CFLEP
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
RDLKPE
N
I
L
LDSQ-G
H
I
V
L
T
D
F
G
L
C
-
K
--
E
-
N
IEHN-STTS--TF-CG
T
P
E
Y
L
A
P
E
V
L
HKQ-----P---YDR
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
YGL-PPFY----SR
N
T
----
A
E
----
M
Y
D
N
I
-LN--KP
L
----
Q
L--K-----PNI
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K--RL-G-A--K--
D
-
D
F
M
E
--
I
K
S
H
V
F
F
S
LI
N
---
W
D
D
L
INKKITPPFNPNVSGPNDLRHFD--PEFT-EE-PVPNSIGKSPD
S
V
L
V
T
A
S
V
K
E
A
A
E
A
F
LGFSY----APPTDSFL
1
PsiBlast_PDB
89.54
98%
-145
- C2 -
-
2R5T
1
SGK1_HUMAN
A:
[24-320]
--------------------------------------------------------------------------------------------------------------------------------------------------
Q
----
I
N
L
G
P
S
S
N
P
H
A
K
-
P
S
D
F
H
F
L
K
V
I
G
K
G
-
S
F
G
K
V
L
L
A
R
H
K
A
---
E
---
E
---
V
-
F
Y
A
V
K
V
L
Q
K
K
A
I
L
---------------
V
L
--
L
K
-
N
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
--
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
-
G
H
I
V
L
T
D
F
G
L
C
-
K
--
E
-
N
I
E
H
N
-
S
T
T
S
--
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
Q
-----
P
---
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
-
P
P
F
Y
----
S
R
N
T
----
A
E
----
M
Y
D
N
I
-
L
N
--
K
P
L
----
Q
L
--
K
-----
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
--
R
L
-
G
-
A
--
K
--
D
-
D
F
M
E
--
I
K
S
H
V
F
F
S
L
I
N
---
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
G
-------------------------------------------------------------
548
HHSearch
87.66
99%
-145
- C2 -
-
2R5T
1
SGK1_HUMAN
A:
[31-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
P
H
A
K
-
P
S
D
F
H
F
L
K
V
I
G
K
G
-
S
F
G
K
V
L
L
A
R
H
K
A
---
E
---
E
---
V
-
F
Y
A
V
K
V
L
Q
K
K
A
I
L
---------------
V
L
--
L
K
-
N
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
--
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
-
G
H
I
V
L
T
D
F
G
L
C
-
K
--
E
-
N
I
E
H
N
-
S
T
T
S
--
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
Q
-----
P
---
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
-
P
P
F
Y
----
S
R
N
T
----
A
E
----
M
Y
D
N
I
-
L
N
--
K
P
L
----
Q
L
--
K
-----
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
--
R
L
-
G
-
A
--
K
--
D
-
D
F
M
E
--
I
K
S
H
V
F
F
S
L
I
N
---
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
G
-------------------------------------------------------------
2
PsiBlast_PDB
87.01
98%
-132
- C2 -
-
3HDM
1
SGK1_HUMAN
A:
[23-320]
-------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
----
I
N
L
G
P
S
S
N
P
H
A
K
-
P
S
D
F
H
F
L
K
V
I
G
K
G
-
S
F
G
K
V
L
L
A
R
H
K
A
---
E
---
E
---
V
-
F
Y
A
V
K
V
L
Q
K
K
A
I
L
---------------
V
L
--
L
K
-
N
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
--
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
-
G
H
I
V
L
T
D
F
G
L
C
-
K
--
E
-
N
I
E
H
N
-
S
T
T
S
--
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
Q
-----
P
---
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
-
P
P
F
Y
----
S
R
N
T
----
A
E
----
M
Y
D
N
I
-
L
N
--
K
P
L
----
Q
L
--
K
-----
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
--
R
L
-
G
-
A
--
K
--
D
-
D
F
M
E
--
I
K
S
H
V
F
F
S
L
I
N
---
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
G
-------------------------------------------------------------
3
PsiBlast_PDB
86.45
98%
-144
- C2 -
-
3HDN
1
SGK1_HUMAN
A:
[24-316]
--------------------------------------------------------------------------------------------------------------------------------------------------
Q
----
I
N
L
G
P
S
S
N
P
H
A
K
-
P
S
D
F
H
F
L
K
V
I
G
K
G
-
S
F
G
K
V
L
L
A
R
H
K
A
---
E
---
E
---
V
-
F
Y
A
V
K
V
L
Q
K
K
A
I
L
---------------
V
L
--
L
K
-
N
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
--
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
-
G
H
I
V
L
T
D
F
G
L
C
-
K
--
E
-
N
I
E
H
N
-
S
T
T
S
--
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
Q
-----
P
---
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
-
P
P
F
Y
----
S
R
N
T
----
A
E
----
M
Y
D
N
I
-
L
N
--
K
P
L
----
Q
L
--
K
-----
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
--
R
L
-
G
-
A
--
K
--
D
-
D
F
M
E
--
I
K
S
H
V
F
F
S
L
I
N
---
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
-----------------------------------------------------------------
547
HHSearch
85.07
99%
-133
- C2 -
-
3HDM
1
SGK1_HUMAN
A:
[31-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
P
H
A
K
-
P
S
D
F
H
F
L
K
V
I
G
K
G
-
S
F
G
K
V
L
L
A
R
H
K
A
---
E
---
E
---
V
-
F
Y
A
V
K
V
L
Q
K
K
A
I
L
---------------
V
L
--
L
K
-
N
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
--
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
-
G
H
I
V
L
T
D
F
G
L
C
-
K
--
E
-
N
I
E
H
N
-
S
T
T
S
--
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
Q
-----
P
---
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
-
P
P
F
Y
----
S
R
N
T
----
A
E
----
M
Y
D
N
I
-
L
N
--
K
P
L
----
Q
L
--
K
-----
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
--
R
L
-
G
-
A
--
K
--
D
-
D
F
M
E
--
I
K
S
H
V
F
F
S
L
I
N
---
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
G
-------------------------------------------------------------
5
PsiBlast_PDB
77.52
48%
-93
- C2 -
-
2JDR
1
AKT2_HUMAN
A:
[6-338]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
-
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
K
A
---
T
---
G
---
R
-
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
-
D
E
V
A
H
T
V
T
E
S
R
V
L
---
Q
-
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
-
K
--
E
-
G
I
S
D
G
-
A
T
M
K
--
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
---
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
----
N
Q
D
H
----
E
R
----
L
F
E
L
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
-
G
-
G
--
G
P-
S
-
D
A
K
E
--
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
--
D
E
F
T
-
A
Q
-
S
I
T
-------------------
Q
E
M
F
E
D
F
D
Y
------------
551
HHSearch
77.41
49%
-93
- C2 -
-
2JDO
2
AKT2_HUMAN
A:
[6-341]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
-
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
K
A
---
T
---
G
---
R
-
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
-
D
E
V
A
H
T
V
T
E
S
R
V
---
L
Q
-
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
-
K
--
E
-
G
I
S
D
G
-
A
T
M
K
--
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
---
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
----
N
Q
D
H
----
E
R
----
L
F
E
L
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
-
G
-
G
--
G
P-
S
-
D
A
K
E
--
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
--
D
E
F
T
-
A
Q
-
S
I
T
---------------------
M
F
E
D
F
D
Y
----
I
A
D
-----
4
PsiBlast_PDB
76.65
48%
-93
- C2 -
-
2JDO
2
AKT2_HUMAN
A:
[6-338]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
-
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
K
A
---
T
---
G
---
R
-
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
-
D
E
V
A
H
T
V
T
E
S
R
V
L
---
Q
-
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
-
K
--
E
-
G
I
S
D
G
-
A
T
M
K
--
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
---
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
----
N
Q
D
H
----
E
R
----
L
F
E
L
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
-
G
-
G
--
G
P-
S
-
D
A
K
E
--
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
--
D
E
F
T
-
A
Q
-
S
I
T
---------------------
M
F
E
D
F
D
Y
------------
9
PsiBlast_PDB
75.73
49%
-92
- C2 -
-
1O6L
1
AKT2_HUMAN
A:
[5-333]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
K
A
---
T
---
G
---
R
-
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
-
D
E
V
A
H
T
V
T
E
S
R
V
L
---
Q
-
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
-
K
--
E
-
G
I
S
D
G
-
A
T
M
K
--
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
---
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
----
N
Q
D
H
----
E
R
----
L
F
E
L
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
-
G
-
G
--
G
P-
S
-
D
A
K
E
--
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
--
D
E
F
T
-
A
Q
-
S
I
T
-------------------
Q
E
M
F
E
D
F
D
Y
------------
7
PsiBlast_PDB
75.73
48%
-90
- C2 -
-
2X39
1
AKT2_HUMAN
A:
[6-338]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
-
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
K
A
---
T
---
G
---
R
-
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
-
D
E
V
A
H
T
V
T
E
S
R
V
L
---
Q
-
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
-
K
--
E
-
G
I
S
D
G
-
A
T
M
K
--
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
---
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
----
N
Q
D
H
----
E
R
----
L
F
E
L
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
-
G
-
G
--
G
P-
S
-
D
A
K
E
--
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
--
D
E
F
T
-
A
Q
-
S
I
T
-------------------
Q
E
M
F
E
D
F
D
Y
------------
8
PsiBlast_PDB
75.38
48%
-97
- C2 -
-
2XH5
1
AKT2_HUMAN
A:
[6-338]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
-
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
K
A
---
T
---
G
---
R
-
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
-
D
E
V
A
H
T
V
T
E
S
R
V
L
---
Q
-
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
-
K
--
E
-
G
I
S
D
G
-
A
T
M
K
--
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
---
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
----
N
Q
D
H
----
E
R
----
L
F
E
L
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
-
G
-
G
--
G
P-
S
-
D
A
K
E
--
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
--
D
E
F
T
-
A
Q
-
S
I
T
-------------------
Q
E
M
F
E
D
F
D
Y
------------
6
PsiBlast_PDB
75.36
48%
-90
- C2 -
-
2UW9
1
AKT2_HUMAN
A:
[6-338]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
-
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
K
A
---
T
---
G
---
R
-
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
-
K
-
D
E
V
A
H
T
V
T
E
S
R
V
L
---
Q
-
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
-
K
--
E
-
G
I
S
D
G
-
A
T
M
K
--
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
---
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
----
N
Q
D
H
----
E
R
----
L
F
E
L
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
-
G
-
G
--
G
P-
S
-
D
A
K
E
--
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
--
D
E
F
T
-
A
Q
-
S
I
T
-------------------
Q
E
M
F
E
D
F
D
Y
------------
549
HHSearch
74.33
43%
-104
- C2 -
-
4RA5
3
KPCT_HUMAN
A:
[3-329]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
I
E
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
F
K
K
---
T
---
N
---
Q
-
F
F
A
I
K
A
L
K
K
D
V
V
L
M
-
D
-
D
D
V
E
C
T
M
V
E
K
R
V
L
--
S
L
-
A
W
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
--
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
-
G
H
I
K
I
A
D
F
G
M
C
-
K
--
E
-
N
M
L
G
D
-
A
K
T
N
--
E
F
-
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
-----
K
---
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
-
S
P
F
H
----
G
Q
D
E
----
E
E
----
L
F
H
S
I
-
R
M
--
D
N
P
----
F
Y
--
P
-----
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
-
G
-
V
--
R
------
G
D
--
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
K
S
P
F
D
C
S
N
F
D
--
K
E
F
L
-
N
E
-
K
P
R
L
S
F
A
D
R
A
---
L
-
I
N
--
S
M
D
Q
N
M
F
R
N
F
S
F
----
M
N
P
G
M
E
--
559
HHSearch
74.16
44%
-87
- C2 -
-
2I0E
-
KPCB_HUMAN
A:
[19-346]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
D
F
N
F
L
M
V
L
G
K
G
-
S
F
G
K
V
M
L
S
E
R
K
G
---
T
---
D
---
E
-
L
Y
A
V
K
I
L
K
K
D
V
V
I
Q
-
D
-
D
D
V
E
C
T
M
V
E
K
R
V
L
--
A
L
-
P
G
K
P
P
F
L
T
Q
L
H
S
C
F
Q
T
M
D
R
L
Y
F
V
M
E
Y
V
N
G
G
D
L
M
Y
H
I
Q
Q
--
V
G
R
F
K
E
P
H
A
V
F
Y
A
A
E
I
A
I
G
L
F
F
L
Q
S
-
K
G
I
I
Y
R
D
L
K
L
D
N
V
M
L
D
S
E
-
G
H
I
K
I
A
D
F
G
M
C
-
K
--
E
-
N
I
W
D
G
-
V
T
T
K
--
T
F
-
C
G
T
P
D
Y
I
A
P
E
I
I
A
Y
Q
-----
P
---
Y
G
K
S
V
D
W
W
A
F
G
V
L
L
Y
E
M
L
A
G
Q
-
A
P
F
E
----
G
E
D
E
----
D
E
----
L
F
Q
S
I
-
M
E
--
H
N
V
----
A
Y
--
P
-----
K
S
M
S
K
E
A
V
A
I
C
K
G
L
M
T
K
H
P
G
K
--
R
L
-
G
-
C
--
G
--
P
E
G
E
R
D
--
I
K
E
H
A
F
F
R
Y
I
D
---
W
E
K
L
E
R
K
E
I
Q
P
P
Y
K
P
K
A
C
G
R
---
E
N
F
D
--
R
F
F
T
-
R
H
-
P
P
V
L
T
P
P
-
D
Q
E
V
I
R
-----
N
I
D
Q
S
E
F
E
G
F
S
F
----
V
N
S
E
F
---
555
HHSearch
73.75
49%
-37
- C2 -
-
4GV1
5
AKT1_HUMAN
A:
[7-337]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
K
A
---
T
---
G
---
R
-
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
-
K
-
D
E
V
A
H
T
L
T
E
N
R
V
---
L
Q
-
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
-
K
--
E
-
G
I
K
D
G
-
A
T
M
K
--
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
---
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
----
N
Q
D
H
----
E
K
----
L
F
E
L
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
-
G
-
G
--
G
--
S
E
D
A
K
E
--
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
--
E
E
F
T
-
A
Q
-
M
I
T
I
T
P
-----
S
M
E
C
--
V
D
S
E
R
R
P
H
F
P
Q
F
D
Y
----
S
A
S
-----
423
Blastp_CBE
73.51
38%
-82
- C2 -
-
5N23
1
KAPCA_HUMAN
A:
[9-337]
------------------------------------------------------------------------------------------------------------------
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
-----------------
A
H
-
L
D
Q
F
E
R
I
R
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
Q
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
K
V
A
D
F
G
F
A
-
K
--
R
-
V
---
K
-
G
R
T
P
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
------
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
124
Blastp_CBE
73.02
43%
-76
- C2 -
-
2UZW
1
KAPCA_BOVIN
E:
[19-325]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
--
R
-
V
---
K
-
G
R
T
W
--
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
D
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
R
V
S
I
-------------------------------------
125
Blastp_CBE
73.01
43%
-78
- C2 -
-
2UZV
1
KAPCA_BOVIN
A:
[19-325]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
--
R
-
V
---
K
-
G
R
T
W
--
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
D
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
R
V
S
I
-------------------------------------
126
Blastp_CBE
72.68
43%
-81
- C2 -
-
2UZU
1
KAPCA_BOVIN
E:
[19-325]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
--
R
-
V
---
K
-
G
R
T
W
--
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
D
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
R
V
S
I
-------------------------------------
127
Blastp_CBE
72.52
43%
-78
- C2 -
-
2UZT
1
KAPCA_BOVIN
A:
[19-325]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
--
R
-
V
---
K
-
G
R
T
W
--
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
D
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
R
V
S
I
-------------------------------------
132
Blastp_CBE
72.09
42%
-83
- C2 -
-
2F7Z
1
KAPCA_BOVIN
E:
[34-340]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
--
R
-
V
---
K
-
G
R
T
W
--
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
R
V
S
I
-------------------------------------
130
Blastp_CBE
71.81
42%
-77
- C2 -
-
2OJF
1
KAPCA_BOVIN
E:
[34-340]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
--
R
-
V
---
K
-
G
R
T
W
--
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
R
V
S
I
-------------------------------------
566
HHSearch
71.07
44%
-95
- C2 -
-
4RA4
1
KPCA_HUMAN
A:
[16-346]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
K
-
L
T
D
F
N
F
L
M
V
L
G
K
G
-
S
F
G
K
V
M
L
A
D
R
K
G
---
T
---
E
---
E
-
L
Y
A
I
K
I
L
K
K
D
V
V
I
Q
-
D
-
D
D
V
E
C
T
M
V
E
K
R
V
L
--
A
L
-
L
D
K
P
P
F
L
T
Q
L
H
S
C
F
Q
T
V
D
R
L
Y
F
V
M
E
Y
V
N
G
G
D
L
M
Y
H
I
Q
Q
--
V
G
K
F
K
E
P
Q
A
V
F
Y
A
A
E
I
S
I
G
L
F
F
L
H
K
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
M
L
D
S
E
-
G
H
I
K
I
A
D
F
G
M
C
-
K
--
E
-
H
M
M
D
G
-
V
T
T
R
--
T
F
-
C
G
T
P
D
Y
I
A
P
E
I
I
A
Y
Q
-----
P
---
Y
G
K
S
V
D
W
W
A
Y
G
V
L
L
Y
E
M
L
A
G
Q
-
P
P
F
D
----
G
E
D
E
----
D
E
----
L
F
Q
S
I
-
M
E
--
H
N
V
----
S
Y
--
P
-----
K
S
L
S
K
E
A
V
S
I
C
K
G
L
M
T
K
H
P
A
K
--
R
L
-
G
-
C
--
G
P-
E
-
G
E
R
D
--
V
R
E
H
A
F
F
R
R
I
D
---
W
E
K
L
E
N
R
E
I
Q
P
P
F
K
P
K
-------------------
G
-
Q
P
V
L
T
P
P
---
D
Q
L
V
I
A
---
N
I
D
Q
S
D
F
E
G
F
S
Y
----
V
N
P
Q
F
---
571
Fugue
71.03
34%
-14
- C2 -
-
4AW2
5
MRCKA_RAT
A:
[1-416]
-----------------------------------------------------------------
S
G
E
V
R
L
R
Q
L
E
Q
F
I
L
D
G
P
A
Q
T
N
G
Q
C
F
S
V
E
T
L
L
D
I
L
I
C
L
--
Y
D
E
C
N
N
S
P
L
R
R
E
K
N
I
L
E
Y
L
E
W
A
K
P
F
T
S
K
V
K
Q
M
R
L
------------------------
H
-
R
E
D
F
E
I
L
K
V
I
G
R
G
-
A
F
G
E
V
A
V
V
K
L
K
N
---
A
---
D
---
K
-
V
F
A
M
K
I
L
N
K
W
E
M
L
K
-
R
-
A
E
T
A
C
F
R
E
E
R
D
V
L
--
V
N
-
G
-
D
S
K
W
I
T
T
L
H
Y
A
F
Q
D
D
N
N
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F-
E
D
R
L
P
E
E
M
A
R
F
Y
L
A
E
M
V
I
A
I
D
S
V
H
Q
-
L
H
Y
V
H
R
D
I
K
P
D
N
I
L
M
D
M
N
-
G
H
I
R
L
A
D
F
G
S
C
-
L
--
K
-
L
M
E
D
G
-
T
V
Q
S
--
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
EGGKG
R
---
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
-
T
P
F
Y
----
A
E
S
L
----
V
E
----
T
Y
G
K
I
-
M
N
--
H
K
E
----
R
F
--
Q
FPTQV
T
D
V
S
E
N
A
K
D
L
I
R
R
L
I
C
-
S
R
E
H
--
R
L
-
G
----
Q
--
N
-
G
I
E
D
--
F
K
K
H
P
F
F
S
G
I
D
---
W
D
N
I
R
N
--
C
E
A
P
Y
I
P
E
V
S
S
P
T
D
T
S
N
F
D
--
V
D
-------------------------
S
G
H
H
L
P
F
V
G
F
T
Y
TSSC
V
L
S
D
R
S
C
L
553
HHSearch
71.01
45%
-67
- C2 -
-
5LI9
13
KPCI_HUMAN
A:
[5-342]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
K
K
---
T
---
D
---
R
-
I
Y
A
M
K
V
V
K
K
E
L
V
N
D
-
D
-
E
D
I
D
W
V
Q
T
E
K
H
V
F
--
E
Q
-
A
S
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
-
G
H
I
K
L
T
D
Y
G
M
C
-
K
--
E
-
G
L
R
P
G
-
D
T
T
S
--
T
F
-
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
-----
D
---
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
---------------TEDY
L
F
Q
V
I
-
L
E
--
K
Q
I
----
R
I
--
P
-----
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
-
G
-
C
--
H
PQ
T
-
G
F
A
D
--
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
--
S
Q
F
T
-
N
E
-
P
V
Q
L
T
P
D
-
D
D
D
--
I
V
-
R
--
K
I
D
Q
S
E
F
E
G
F
E
Y
----
I
N
P
L
----
131
Blastp_CBE
70.84
42%
-81
- C2 -
-
2OH0
1
KAPCA_BOVIN
E:
[34-340]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
--
R
-
V
---
K
-
G
R
T
W
--
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
R
V
S
I
-------------------------------------
134
Blastp_CBE
70.71
42%
-76
- C2 -
-
2F7E
1
KAPCA_BOVIN
E:
[34-340]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
--
R
-
V
---
K
-
G
R
T
W
--
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
R
V
S
I
-------------------------------------
133
Blastp_CBE
70.67
42%
-75
- C2 -
-
2F7X
1
KAPCA_BOVIN
E:
[34-340]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
--
R
-
V
---
K
-
G
R
T
W
--
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
R
V
S
I
-------------------------------------
111
Blastp_CBE
70.25
45%
-76
- C2 -
-
5F9E
1
KPCT_HUMAN
A:
[15-312]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
K
-
I
E
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
F
K
K
---
T
---
N
---
Q
-
F
F
A
I
K
A
L
K
K
D
V
V
L
M
-
D
-
D
D
V
E
C
T
M
V
E
K
R
V
L
--
S
L
-
A
W
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
--
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
-
G
H
I
K
I
A
D
F
G
M
C
-
K
--
E
-
N
M
L
G
D
-
A
K
T
N
--
E
F
-
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
-----
K
---
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
-
S
P
F
H
----
G
Q
D
E
----
E
E
----
L
F
H
S
I
R
M
D
--
N
P
F
----
Y
P
--
R
-----
W
-
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
-
G
-
V
--
R
--
G
-
D
-----
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
K
S
P
F
D
C
S
N
F
D
--
K
E
F
L
-
N
E
--------------------------------------------
120
Blastp_CBE
69.97
46%
-77
- C2 -
-
4Q9Z
1
KPCT_HUMAN
A:
[3-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
I
E
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
F
K
K
---
T
---
N
---
Q
-
F
F
A
I
K
A
L
K
K
D
V
V
L
M
-
D
-
D
D
V
E
C
T
M
V
E
K
R
V
L
--
S
L
-
A
W
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
--
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
-
G
H
I
K
I
A
D
F
G
M
C
-
K
--
E
-
N
M
L
G
D
-
A
K
T
N
--
E
F
-
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
-----
K
---
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
-
S
P
F
H
----
G
Q
D
E
----
E
E
----
L
F
H
S
I
R
M
D
--
N
P
F
----
Y
P
--
R
-----
W
-
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
-
G
-
V
--
R
--
G
-
D
-----
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
K
S
P
F
D
C
S
N
F
D
--
K
E
F
L
-
N
E
--------------------------------------------
556
HHSearch
69.34
45%
-64
- C2 -
-
5LI1
2
KPCI_HUMAN
A:
[8-346]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-
L
Q
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
K
K
---
T
---
D
---
R
-
I
Y
A
M
K
V
V
K
K
E
L
V
N
D
-
D
-
E
D
I
D
W
V
Q
T
E
K
H
V
F
--
E
Q
-
A
S
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
-
G
H
I
K
L
T
D
Y
G
M
C
-
K
--
E
-
G
L
R
P
G
-
D
T
T
S
--
T
F
-
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
-----
D
---
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
D
----
I
---------TEDY
L
F
Q
V
I
-
L
E
--
K
Q
I
----
R
I
--
P
-----
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
-
G
-
C
--
H
PQ
T
-
G
F
A
D
--
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
--
S
Q
F
T
-
N
E
-
P
V
Q
L
T
P
D
-
D
D
D
I
--
V
-
R
--
K
I
D
Q
S
E
F
E
G
F
E
Y
----
I
N
P
L
----
118
Blastp_CBE
68.35
46%
-79
- C2 -
-
4RA5
3
KPCT_HUMAN
A:
[3-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
I
E
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
F
K
K
---
T
---
N
---
Q
-
F
F
A
I
K
A
L
K
K
D
V
V
L
M
-
D
-
D
D
V
E
C
T
M
V
E
K
R
V
L
--
S
L
-
A
W
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
--
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
-
G
H
I
K
I
A
D
F
G
M
C
-
K
--
E
-
N
M
L
G
D
-
A
K
T
N
--
E
F
-
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
-----
K
---
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
-
S
P
F
H
----
G
Q
D
E
----
E
E
----
L
F
H
S
I
R
M
D
--
N
P
F
----
Y
P
--
R
-----
W
-
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
-
G
-
V
--
R
--
G
-
D
-----
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
K
S
P
F
D
C
S
N
F
D
--
K
E
F
L
-
N
E
--------------------------------------------
313
Blastp_CBE
68.24
39%
-66
- C2 -
-
5N3B
2
KAPCA_CRIGR
A:
[7-338]
--------------------------------------------------------------------------------------------------------------
A
A
A
A
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
------------------
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
550
HHSearch
68.11
43%
-127
- C2 -
-
1XJD
1
A:
[16-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
D
F
I
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
F
K
K
---
T
---
N
---
Q
-
F
F
A
I
K
A
L
K
K
D
V
V
L
M
-
D
-
D
D
V
E
C
T
M
V
E
K
R
V
L
--
S
L
-
A
W
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
--
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
-
G
H
I
K
I
A
D
F
G
M
C
-
K
--
E
-
N
M
L
G
D
-
A
K
T
N
--
T
F
-
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
-----
K
---
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
-
S
P
F
H
----
G
Q
D
E
----
E
E
----
L
F
H
S
I
-
R
M
--
D
N
P
----
F
Y
--
P
-----
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
-
G
-
V
--
R
------
G
D
--
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
------------------------------------------------
Q
N
M
F
R
N
F
S
F
------------
117
Blastp_CBE
68.09
46%
-77
- C2 -
-
4RA5
1
B:
[3-320]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
I
E
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
F
K
K
---
T
---
N
---
Q
-
F
F
A
I
K
A
L
K
K
D
V
V
L
M
-
D
-
D
D
V
E
C
T
M
V
E
K
R
V
L
--
S
L
-
A
W
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
--
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
-
G
H
I
K
I
A
D
F
G
M
C
-
K
--
E
-
N
M
L
G
D
-
A
K
T
N
--
E
F
-
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
-----
K
---
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
-
S
P
F
H
----
G
Q
D
E
----
E
E
----
L
F
H
S
I
R
M
D
--
N
P
F
----
Y
P
--
R
-----
W
-
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
-
G
-
V
--
R
--
G
-
D
-----
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
K
S
P
F
D
C
S
N
F
D
--
K
E
F
L
-
N
E
--------------------------------------------
552
HHSearch
68.05
43%
-79
- C2 -
-
3TXO
1
KPCL_HUMAN
A:
[23-349]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
F
E
F
I
R
V
L
G
K
G
-
S
F
G
K
V
M
L
A
R
V
K
E
---
T
---
G
---
D
-
L
Y
A
V
K
V
L
K
K
D
V
I
L
Q
-
D
-
D
D
V
E
C
T
M
T
E
K
R
I
L
--
S
L
-
A
R
N
H
P
F
L
T
Q
L
F
C
C
F
Q
T
P
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
--
S
R
R
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
-
K
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
H
E
-
G
H
C
K
L
A
D
F
G
M
C
-
K
--
E
-
G
I
-------------
C
G
T
P
D
Y
I
A
P
E
I
L
Q
E
M
-----
L
---
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
-
A
P
F
E
----
A
E
N
E
----
D
D
----
L
F
E
A
I
-
L
N
--
D
E
V
----
V
Y
--
P
-----
T
W
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
--
R
L
-
G
-
S
--
L
TQ
G
-
G
E
H
A
--
I
L
R
H
P
F
F
K
E
I
D
---
W
A
Q
L
N
H
R
Q
I
E
P
P
F
R
P
R
I
K
S
R
E
D
V
S
N
F
D
--
P
D
F
I
-
K
E
-
E
P
V
L
T
P
I
D
E
G
------
H
L
P
M
I
N
Q
D
E
F
R
N
F
E
Y
----
V
S
P
-----
69
Blastp_CBE
67.92
41%
-54
- C2 -
-
4DC2
1
KPCI_MOUSE
A:
[49-387]
-------------------------------------------------------------------------------------------------------------------------------------------------
L
G
----
L
Q
-------------
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
K
K
---
T
---
D
---
R
-
I
Y
A
M
R
V
V
K
K
E
L
V
N
------
I
D
W
V
Q
T
E
K
H
V
F
--
E
Q
-
A
S
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
-
G
H
I
K
L
T
D
Y
G
M
C
-
K
--
E
-
G
L
R
P
G
-
D
T
T
S
--
T
F
-
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
-----
D
---
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
D
IVGS--
N
T
----
E
D
Y---
L
F
Q
V
I
-
L
E
--
K
Q
I
----
R
I
--
P
-----
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
-
G
-
C
HP
Q
--
T
-
G
F
A
D
--
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
--
S
Q
F
T
-
N
E
-
P
V
-----
Q
L
P
D
D
D
D
I
V
R
K
I
D
Q
S
--
E
F
E
G
F
E
Y
----
I
N
P
-----
85
Blastp_CBE
67.65
43%
-58
- C2 -
-
5LI9
13
KPCI_HUMAN
A:
[7-341]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
K
K
---
T
---
D
---
R
-
I
Y
A
M
K
V
V
K
K
E
L
V
N
D
-
D
-
E
D
I
D
W
V
Q
T
E
K
H
V
F
--
E
Q
-
A
S
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
-
G
H
I
K
L
T
D
Y
G
M
C
-
K
--
E
-
G
L
R
P
G
-
D
T
T
S
--
T
F
-
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
-----
D
---
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
--------
T
----
E
D
Y---
L
F
Q
V
I
-
L
E
--
K
Q
I
----
R
I
--
P
-----
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
-
G
-
C
HP
Q
--
T
-
G
F
A
D
--
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
--
S
Q
F
T
-
N
E
-
P
V
-----
Q
L
P
D
D
D
D
I
V
R
K
I
D
Q
S
--
E
F
E
G
F
E
Y
----
I
N
P
-----
319
Blastp_CBE
67.44
39%
-72
- C2 -
-
5N1O
2
KAPCA_CRIGR
A:
[10-338]
-----------------------------------------------------------------------------------------------------------------
A
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
---------------------
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
-
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
57
Blastp_CBE
67.30
47%
-12
- C2 -
-
4L46
1
KS6B1_HUMAN
A:
[9-345]
--------------------------------------------------------------------------------------------------------------------------------------------------------
N
R
G
P
E
K
---
I
R
-
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
---
G
---
A
NTG
K
-
I
F
A
M
K
V
L
K
K
A
M
I
V
R
-
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
---
E
-
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
L
C
-
K
--
E
-
S
I
H
D
-----
H
--
T
F
-
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
-----
G
---
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
T
----
G
E
N
R
----
K
K
----
T
I
D
K
I
-
L
K
--
C
K
L
----
N
L
--
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
-
G
-
A
--
G
P-
G
-
D
A
G
E
--
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
---
E
E
D
V
S
Q
F
D
--
S
K
F
T
-
R
Q
T
P
V
---------------------
Q
V
F
L
G
F
Y
V
----
A
P
------
162
Blastp_CBE
67.25
39%
-69
- C2 -
-
5N32
3
KAPCA_CRIGR
A:
[4-338]
------------------------------------------------------------------------------------------------------------
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-------------------
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
-
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
195
Blastp_CBE
67.22
38%
-62
- C2 -
-
3VQH
2
KAPCA_HUMAN
A:
[5-336]
--------------------------------------------------------------------------------------------------------------
A
A
A
A
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
-----------------
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
110
Blastp_CBE
67.19
45%
-80
- C2 -
-
5F9E
1
B:
[16-340]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
-
I
E
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
F
K
K
---
T
---
N
---
Q
-
F
F
A
I
K
A
L
K
K
D
V
V
L
M
-
D
-
D
D
V
E
C
T
M
V
E
K
R
V
L
--
S
L
-
A
W
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
--
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
-
G
H
I
K
I
A
D
F
G
M
C
-
K
--
E
-
N
M
L
G
D
-
A
K
T
N
--
E
F
-
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
-----
K
---
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
-
S
P
F
H
----
G
Q
D
E
----
E
E
----
L
F
H
S
I
R
M
D
--
N
P
F
----
Y
P
--
R
-----
W
-
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
-
G
-
V
--
R
--
G
-
D
-----
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
K
S
P
F
--
S
N
F
D
----
F
L
-
N
E
--------------------------------------------
119
Blastp_CBE
67.18
46%
-71
- C2 -
-
4Q9Z
1
B:
[3-320]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
I
E
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
F
K
K
---
T
---
N
---
Q
-
F
F
A
I
K
A
L
K
K
D
V
V
L
M
-
D
-
D
D
V
E
C
T
M
V
E
K
R
V
L
--
S
L
-
A
W
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
--
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
-
G
H
I
K
I
A
D
F
G
M
C
-
K
--
E
-
N
M
L
G
D
-
A
K
T
N
--
E
F
-
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
-----
K
---
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
-
S
P
F
H
----
G
Q
D
E
----
E
E
----
L
F
H
S
I
R
M
D
--
N
P
F
----
Y
P
--
R
-----
W
-
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
-
G
-
V
--
R
--
G
-
D
-----
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
K
S
P
F
D
C
S
N
F
D
--
K
E
F
L
-
N
E
--------------------------------------------
78
Blastp_CBE
67.14
45%
-90
- C2 -
-
3TXO
1
A:
[23-324]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
F
E
F
I
R
V
L
G
K
G
-
S
F
G
K
V
M
L
A
R
V
K
E
---
T
---
G
---
D
-
L
Y
A
V
K
V
L
K
K
D
V
I
L
Q
-
D
-
D
D
V
E
C
T
M
T
E
K
R
I
L
--
S
L
-
A
R
N
H
P
F
L
T
Q
L
F
C
C
F
Q
T
P
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
--
S
R
R
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
-
K
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
H
E
-
G
H
C
K
L
A
D
F
G
M
C
-
K
--
E
-
G
I
-------------
C
G
T
P
D
Y
I
A
P
E
I
L
Q
E
M
-----
L
---
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
-
A
P
F
E
----
A
E
N
E
----
D
D
----
L
F
E
A
I
-
L
N
--
D
E
V
----
V
Y
--
P
-----
T
W
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
--
R
L
-
G
-
S
--
L
--
T
-
Q
G
G
E
HA
I
L
R
H
P
F
F
K
E
I
D
---
W
A
Q
L
N
H
R
Q
I
E
P
P
F
R
P
R
I
K
S
R
E
D
V
S
N
F
D
--
P
D
F
I
K
E
E
-
P
V
-----------------------------------------
93
Blastp_CBE
67.04
43%
-68
- C2 -
-
3A8W
1
KPCI_HUMAN
A:
[9-344]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
K
K
---
T
---
D
---
R
-
I
Y
A
M
K
V
V
K
K
E
L
V
N
------
I
D
W
V
Q
T
E
K
H
V
F
--
E
Q
-
A
S
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
-
G
H
I
K
L
T
D
Y
G
M
C
-
K
--
E
-
G
L
R
P
G
-
D
T
T
S
--
T
F
-
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
-----
D
---
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
D
-------
T
----
E
D
Y---
L
F
Q
V
I
-
L
E
--
K
Q
I
----
R
I
--
P
-----
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
-
G
-
C
HP
Q
--
T
-
G
F
A
D
--
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
--
S
Q
F
T
-
N
E
-
P
V
-----
Q
L
P
D
D
D
D
I
V
R
K
I
D
Q
S
--
E
F
E
G
F
E
Y
----
I
N
P
-----
192
Blastp_CBE
66.80
38%
-69
- C2 -
-
5BX7
4
KAPCA_HUMAN
A:
[6-336]
---------------------------------------------------------------------------------------------------------------
A
A
A
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
-----------------
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
194
Blastp_CBE
66.71
38%
-65
- C2 -
-
4UJB
3
KAPCA_HUMAN
A:
[5-336]
--------------------------------------------------------------------------------------------------------------
A
A
A
A
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
-----------------
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
193
Blastp_CBE
66.65
38%
-65
- C2 -
-
5BX6
4
KAPCA_HUMAN
A:
[6-336]
---------------------------------------------------------------------------------------------------------------
A
A
A
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
-----------------
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
184
Blastp_CBE
66.26
39%
-62
- C2 -
-
4DFX
5
KAPCA_MOUSE
E:
[1-335]
-----------------------------------------------------------------------------------------------------------
G
N
A
A
A
A
C
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
-----------------
S
Q
N
T
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
271
Blastp_CBE
66.12
39%
-63
- C2 -
-
6I2B
2
KAPCA_CRIGR
A:
[7-338]
--------------------------------------------------------------------------------------------------------------
A
A
A
A
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
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P
E
N
L
L
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Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
--
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
87
Blastp_CBE
66.07
43%
-75
- C2 -
-
6ILZ
1
KPCI_HUMAN
E:
[12-344]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
---------
D
---
R
-
I
Y
A
M
K
V
V
K
K
E
L
V
N
D
-
D
-
E
D
I
D
W
V
Q
T
E
K
H
V
F
--
E
Q
-
A
S
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
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A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
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E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
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E
-
G
H
I
K
L
T
D
Y
G
M
C
-
K
--
E
-
G
L
R
P
G
-
D
T
T
S
--
T
F
-
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
-----
D
---
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
D
------------
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D
Y---
L
F
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V
I
-
L
E
--
K
Q
I
----
R
I
--
P
-----
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
-
G
-
C
HP
Q
--
T
-
G
F
A
D
--
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
--
S
Q
F
---
E
-
P
V
-----
Q
L
P
D
D
D
D
I
V
R
K
I
D
Q
S
--
E
F
E
G
F
E
Y
----
I
N
P
-----
281
Blastp_CBE
66.03
39%
-66
- C2 -
-
6EM6
1
KAPCA_CRIGR
A:
[14-338]
---------------------------------------------------------------------------------------------------------------------
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
336
Blastp_CBE
65.87
39%
-65
- C2 -
-
6EM7
4
KAPCA_CRIGR
A:
[13-338]
--------------------------------------------------------------------------------------------------------------------
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
328
Blastp_CBE
65.89
39%
-68
- C2 -
-
5NW8
2
KAPCA_CRIGR
A:
[12-336]
---------------------------------------------------------------------------------------------------------------------
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
86
Blastp_CBE
65.87
43%
-62
- C2 -
-
6ILZ
1
KPCI_HUMAN
G:
[11-344]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
---------
D
---
R
-
I
Y
A
M
K
V
V
K
K
E
L
V
N
D
-
D
-
E
D
I
D
W
V
Q
T
E
K
H
V
F
--
E
Q
-
A
S
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
-
G
H
I
K
L
T
D
Y
G
M
C
-
K
--
E
-
G
L
R
P
G
-
D
T
T
S
--
T
F
-
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
-----
D
---
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
D
I-----------
E
D
Y---
L
F
Q
V
I
-
L
E
--
K
Q
I
----
R
I
--
P
-----
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
-
G
-
C
HP
Q
--
T
-
G
F
A
D
--
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
---
F
G
L
D
N
F
D
--
S
Q
F
---
E
-
P
V
-----
Q
L
P
D
D
D
D
I
V
R
K
I
D
Q
S
--
E
F
E
G
F
E
Y
----
I
N
P
-----
92
Blastp_CBE
65.74
43%
-61
- C2 -
-
3A8W
1
KPCI_HUMAN
B:
[9-344]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
K
K
---
T
---
D
---
R
-
I
Y
A
M
K
V
V
K
K
E
L
V
N
D
-
D
-
E
D
I
D
W
V
Q
T
E
K
H
V
F
--
E
Q
-
A
S
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
-
G
H
I
K
L
T
D
Y
G
M
C
-
K
--
E
-
G
---
G
-
D
T
T
S
--
T
F
-
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
-----
D
---
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
D
-------
T
----
E
D
Y---
L
F
Q
V
I
-
L
E
--
K
Q
I
----
R
I
--
P
-----
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
-
G
-
C
HP
Q
--
T
-
G
F
A
D
--
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
--
S
Q
F
T
-
N
E
-
P
V
-----
Q
L
P
D
D
D
D
I
V
R
K
I
D
Q
S
--
E
F
E
G
F
E
Y
----
I
N
P
-----
293
Blastp_CBE
65.57
39%
-61
- C2 -
-
5O5M
1
KAPCA_CRIGR
A:
[12-338]
------------------------------------------------------------------------------------------------------------
G
N
-------
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
--
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
82
Blastp_CBE
65.57
43%
-59
- C2 -
-
3ZH8
4
KPCI_HUMAN
A:
[6-340]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
K
K
---
T
---
D
---
R
-
I
Y
A
M
K
V
V
K
K
E
L
V
N
D
-
D
-
E
D
I
D
W
V
Q
T
E
K
H
V
F
--
E
Q
-
A
S
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
-
G
H
I
K
L
T
D
Y
G
M
C
-
K
--
E
-
G
L
R
P
G
-
D
T
T
S
--
T
F
-
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
-----
D
---
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
D
IV----
N
T
----
E
D
Y---
L
F
Q
V
I
-
L
E
--
K
Q
I
----
R
I
--
P
-----
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
-
G
-
C
HP
Q
--
T
-
G
F
A
D
--
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
----------
Q
F
T
-------------
P
D
D
D
D
I
V
R
K
I
D
Q
S
--
E
F
E
G
F
E
Y
----
I
N
P
-----
182
Blastp_CBE
65.40
39%
-60
- C2 -
-
4X6R
5
KAPCA_MOUSE
A:
[1-335]
-----------------------------------------------------------------------------------------------------------
G
N
A
A
A
A
C
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
-----------------
S
Q
N
T
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
325
Blastp_CBE
65.39
39%
-60
- C2 -
-
5N1F
3
KAPCA_CRIGR
A:
[14-338]
---------------------------------------------------------------------------------------------------------------------
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
88
Blastp_CBE
65.38
43%
-70
- C2 -
-
6ILZ
1
KPCI_HUMAN
C:
[11-344]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
---------
D
---
R
-
I
Y
A
M
K
V
V
K
K
E
L
V
N
D
-
D
-
E
D
I
D
W
V
Q
T
E
K
H
V
F
--
E
Q
-
A
S
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
-
G
H
I
K
L
T
D
Y
G
M
C
-
K
--
E
-
G
L
R
P
G
-
D
T
T
S
--
T
F
-
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
-----
D
---
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
D
------------
E
D
Y---
L
F
Q
V
I
-
L
E
--
K
Q
I
----
R
I
--
P
-----
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
-
G
-
C
HP
Q
--
T
-
G
F
A
D
--
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
--
S
Q
---
N
E
-
P
V
-----
Q
L
P
D
D
D
D
I
V
R
K
I
D
Q
S
--
E
F
E
G
F
E
Y
----
I
N
P
-----
269
Blastp_CBE
65.29
39%
-61
- C2 -
-
6I2D
1
KAPCA_CRIGR
A:
[11-338]
------------------------------------------------------------------------------------------------------------------
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
280
Blastp_CBE
65.22
39%
-67
- C2 -
-
6EMA
2
KAPCA_CRIGR
A:
[14-338]
---------------------------------------------------------------------------------------------------------------------
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
56
Blastp_CBE
65.16
46%
-5
- C2 -
-
4L45
1
KS6B1_HUMAN
A:
[10-346]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
G
P
E
K
---
I
R
-
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
---
G
---
A
NTG
K
-
I
F
A
M
K
V
L
K
K
A
M
I
V
R
-
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
---
E
-
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
L
C
-
K
--
E
-
S
---------------
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
-----
G
---
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
T
----
G
E
N
R
----
K
K
----
T
I
D
K
I
-
L
K
--
C
K
L
----
N
L
--
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
-
G
-
A
--
G
P-
G
-
D
A
G
E
--
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
E
E
D
V
S
Q
F
D
--
S
K
F
T
-
R
Q
T
P
V
--------------
E
S
---
A
N
Q
V
F
L
G
F
E
Y
----
V
A
P
S
----
173
Blastp_CBE
65.12
39%
-67
- C2 -
-
5M0C
3
KAPCA_CRIGR
A:
[16-338]
-----------------------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
308
Blastp_CBE
65.08
39%
-60
- C2 -
-
5N3G
4
KAPCA_CRIGR
A:
[14-338]
---------------------------------------------------------------------------------------------------------------------
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
302
Blastp_CBE
65.08
39%
-58
- C2 -
-
5N3M
6
KAPCA_CRIGR
A:
[14-338]
---------------------------------------------------------------------------------------------------------------------
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
278
Blastp_CBE
65.06
39%
-60
- C2 -
-
6EMD
1
KAPCA_CRIGR
A:
[11-338]
------------------------------------------------------------------------------------------------------------------
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
301
Blastp_CBE
65.03
39%
-59
- C2 -
-
5N3O
6
KAPCA_CRIGR
A:
[16-338]
-----------------------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
273
Blastp_CBE
65.05
39%
-37
- C2 -
-
6ESA
4
KAPCA_CRIGR
A:
[13-338]
--------------------------------------------------------------------------------------------------------------------
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
163
Blastp_CBE
65.03
39%
-62
- C2 -
-
5N1K
4
KAPCA_CRIGR
A:
[1-338]
------------------------------------------------------------------------------------------------------------
G
N
--
A
A
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-------------------
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
----
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
84
Blastp_CBE
64.94
43%
-65
- C2 -
-
5LIH
3
KPCI_HUMAN
A:
[6-340]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
K
K
---
T
---
D
---
R
-
I
Y
A
M
K
V
V
K
K
E
L
V
---------
W
V
Q
T
E
K
H
V
F
--
E
Q
-
A
S
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
-
G
H
I
K
L
T
D
Y
G
M
C
-
K
--
E
-
G
L
R
P
G
-
D
T
T
S
--
T
F
-
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
-----
D
---
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
D
I----
Q
N
T
----
E
D
Y---
L
F
Q
V
I
-
L
E
--
K
Q
I
----
R
I
--
P
-----
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
-
G
-
C
HP
Q
--
T
-
G
F
A
D
--
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
--
S
Q
F
T
-
N
E
-
P
V
-----
Q
L
P
D
D
D
D
I
V
R
K
I
D
Q
S
--
E
F
E
G
F
E
Y
----
I
N
P
-----
285
Blastp_CBE
64.91
39%
-61
- C2 -
-
6EGW
1
KAPCA_CRIGR
A:
[16-338]
-----------------------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
---
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
-
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
233
Blastp_CBE
64.91
42%
-70
- C2 -
-
5JR7
1
KAPCA_MOUSE
A:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
304
Blastp_CBE
64.87
39%
-57
- C2 -
-
5N3K
5
KAPCA_CRIGR
A:
[14-338]
---------------------------------------------------------------------------------------------------------------------
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
324
Blastp_CBE
64.74
39%
-59
- C2 -
-
5N1G
4
KAPCA_CRIGR
A:
[14-338]
---------------------------------------------------------------------------------------------------------------------
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
81
Blastp_CBE
64.73
43%
-58
- C2 -
-
3ZH8
5
KPCI_HUMAN
B:
[6-340]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
K
K
---
T
---
D
---
R
-
I
Y
A
M
K
V
V
K
K
E
L
V
N
D
-
D
-
E
D
I
D
W
V
Q
T
E
K
H
V
F
--
E
Q
-
A
S
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
-
G
H
I
K
L
T
D
Y
G
M
C
-
K
--
E
-
G
L
R
P
G
-
D
T
T
S
--
T
F
-
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
-----
D
---
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
D
IV----
N
T
----
E
D
Y---
L
F
Q
V
I
-
L
E
--
K
Q
I
----
R
I
--
P
-----
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
-
G
-
C
HP
Q
--
T
-
G
F
A
D
--
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
----------
Q
F
T
-------------
P
D
D
D
D
I
V
R
K
I
D
Q
S
--
E
F
E
G
F
E
Y
----
I
N
P
-----
309
Blastp_CBE
64.67
39%
-70
- C2 -
-
5N3F
4
KAPCA_CRIGR
A:
[10-336]
-----------------------------------------------------------------------------------------------------------------
A
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
--------------------
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
--
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
--
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
------------------------------------------
297
Blastp_CBE
64.65
39%
-58
- C2 -
-
5N3S
5
KAPCA_CRIGR
A:
[14-338]
---------------------------------------------------------------------------------------------------------------------
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
121
Blastp_CBE
64.62
39%
-73
- C2 -
-
4NTT
1
KAPCA_MOUSE
B:
[10-335]
--------------------------------------------------------------------------------------------------------------------
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
-----------------
S
Q
N
T
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
332
Blastp_CBE
64.59
42%
-64
- C2 -
-
1XHA
1
KAPCA_BOVIN
A:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
E
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
L
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
334
Blastp_CBE
64.56
38%
-61
- C2 -
-
4WB6
1
KAPCA_HUMAN
B:
[8-335]
------------------------------------------------------------------------------------------------------------------
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
-----------------
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
R
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
305
Blastp_CBE
64.55
39%
-59
- C2 -
-
5N3J
4
KAPCA_CRIGR
A:
[14-338]
---------------------------------------------------------------------------------------------------------------------
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
307
Blastp_CBE
64.53
39%
-57
- C2 -
-
5N3H
4
KAPCA_CRIGR
A:
[14-338]
---------------------------------------------------------------------------------------------------------------------
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
247
Blastp_CBE
64.52
42%
-67
- C2 -
-
3X2V
1
KAPCA_MOUSE
A:
[40-342]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
398
Blastp_CBE
64.47
42%
-68
- C2 -
-
2JDS
1
KAPCA_BOVIN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
172
Blastp_CBE
64.50
39%
-61
- C2 -
-
5M0L
3
KAPCA_CRIGR
A:
[14-338]
---------------------------------------------------------------------------------------------------------------------
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
181
Blastp_CBE
64.47
45%
-88
- C2 -
-
1XJD
1
A:
[16-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
D
F
I
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
F
K
K
---
T
---
N
---
Q
-
F
F
A
I
K
A
L
K
K
D
V
V
L
M
-
D
-
D
D
V
E
C
T
M
V
E
K
R
V
L
--
S
L
-
A
W
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
--
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
-
G
H
I
K
I
A
D
F
G
M
C
-
K
--
E
-
N
M
L
G
D
-
A
K
T
N
--
T
F
-
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
-----
K
---
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
-
S
P
F
H
----
G
Q
D
E
----
E
E
----
L
F
H
S
I
R
M
D
--
N
P
F
----
Y
P
--
R
-----
W
-
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
-
G
-
V
--
R
--
G
-
D
-----
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
------
K
S
P
F
D
C
S
N
F
------------------------------------------------------
333
Blastp_CBE
64.45
42%
-69
- C2 -
-
1SMH
6
KAPCA_BOVIN
A:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
E
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
L
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
159
Blastp_CBE
64.44
42%
-67
- C2 -
-
2GU8
1
KAPCA_HUMAN
A:
[20-322]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
E
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
276
Blastp_CBE
64.42
39%
-62
- C2 -
-
6ERT
1
KAPCA_CRIGR
A:
[16-338]
-----------------------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
337
Blastp_CBE
64.38
42%
-70
- C2 -
-
4IJ9
1
KAPCA_BOVIN
A:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
303
Blastp_CBE
64.40
39%
-58
- C2 -
-
5N3L
4
KAPCA_CRIGR
A:
[14-338]
---------------------------------------------------------------------------------------------------------------------
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
323
Blastp_CBE
64.38
39%
-61
- C2 -
-
5N1H
3
KAPCA_CRIGR
A:
[14-338]
---------------------------------------------------------------------------------------------------------------------
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
188
Blastp_CBE
64.36
42%
-64
- C2 -
-
4DG3
1
KAPCA_MOUSE
E:
[54-360]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
A
V
S
I
-------------------------------------
216
Blastp_CBE
64.35
42%
-66
- C2 -
-
3OOG
1
KAPCA_HUMAN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
207
Blastp_CBE
64.32
42%
-67
- C2 -
-
4UJA
2
KAPCA_HUMAN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
215
Blastp_CBE
64.30
42%
-65
- C2 -
-
3OVV
2
KAPCA_HUMAN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
335
Blastp_CBE
64.28
42%
-69
- C2 -
-
1XH9
4
KAPCA_BOVIN
A:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
E
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
L
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
55
Blastp_CBE
64.27
46%
-3
- C2 -
-
4L43
1
KS6B1_HUMAN
A:
[10-346]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
G
P
E
K
---
I
R
-
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
---
G
---
A
NTG
K
-
I
F
A
M
K
V
L
K
K
A
M
I
V
R
-
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
---
E
-
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
L
C
-
K
--
E
-
S
---------------
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
-----
G
---
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
T
----
G
E
N
R
----
K
K
----
T
I
D
K
I
-
L
K
--
C
K
L
----
N
L
--
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
-
G
-
A
--
G
P-
G
-
D
A
G
E
--
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
E
E
D
V
S
Q
F
D
--
S
K
F
T
-
R
Q
T
P
V
---------------
S
---
A
N
Q
V
F
L
G
F
A
Y
----
V
A
P
S
----
54
Blastp_CBE
64.26
46%
6
- C2 -
-
4L44
1
KS6B1_HUMAN
A:
[10-346]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
G
P
E
K
---
I
R
-
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
---
G
---
A
NTG
K
-
I
F
A
M
K
V
L
K
K
A
M
I
V
R
-
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
---
E
-
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
L
C
-
K
--
E
-
S
I
H
------
H
--
T
F
-
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
-----
G
---
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
T
----
G
E
N
R
----
K
K
----
T
I
D
K
I
-
L
K
--
C
K
L
----
N
L
--
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
-
G
-
A
--
G
P-
G
-
D
A
G
E
--
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
E
E
D
V
S
Q
-
D
--
S
K
F
T
-
R
Q
T---------------
S
E
S
---
A
N
Q
V
F
L
G
F
A
Y
----
V
A
P
S
----
198
Blastp_CBE
64.21
42%
-67
- C2 -
-
1YDT
1
KAPCA_BOVIN
E:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
D
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
146
Blastp_CBE
64.20
42%
-67
- C2 -
-
1FMO
1
KAPCA_MOUSE
E:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
380
Blastp_CBE
64.08
41%
-67
- C2 -
-
3NX8
3
KAPCA_HUMAN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
-
N
--
L
--
K
-
N
G
V
N
--
D
I
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
368
Blastp_CBE
64.15
42%
-68
- C2 -
-
1SVE
2
KAPCA_BOVIN
A:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
149
Blastp_CBE
64.12
42%
-68
- C2 -
-
1BX6
1
KAPCA_MOUSE
A:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
148
Blastp_CBE
64.12
42%
-62
- C2 -
-
2ERZ
1
KAPCA_MOUSE
E:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
353
Blastp_CBE
64.08
42%
-71
- C2 -
-
2C1A
1
KAPCA_BOVIN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
136
Blastp_CBE
64.10
42%
-66
- C2 -
-
4DIN
1
KAPCA_MOUSE
A:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
226
Blastp_CBE
64.08
42%
-69
- C2 -
-
3DND
1
KAPCA_BOVIN
A:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
D
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
349
Blastp_CBE
64.07
42%
-68
- C2 -
-
3ZO4
4
KAPCA_BOVIN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
282
Blastp_CBE
64.05
39%
-59
- C2 -
-
6EM2
2
KAPCA_CRIGR
A:
[14-338]
---------------------------------------------------------------------------------------------------------------------
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
299
Blastp_CBE
64.04
39%
-60
- C2 -
-
5N3Q
4
KAPCA_CRIGR
A:
[15-338]
----------------------------------------------------------------------------------------------------------------------
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
142
Blastp_CBE
64.02
42%
-70
- C2 -
-
1REK
2
KAPCA_MOUSE
A:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
200
Blastp_CBE
64.00
42%
-65
- C2 -
-
1YDR
1
KAPCA_BOVIN
E:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
D
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
122
Blastp_CBE
63.96
39%
-73
- C2 -
-
4NTT
1
KAPCA_MOUSE
A:
[10-335]
--------------------------------------------------------------------------------------------------------------------
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
-----------------
S
Q
N
T
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
267
Blastp_CBE
63.93
42%
-61
- C2 -
-
3MVJ
1
KAPCA_HUMAN
A:
[54-356]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
402
Blastp_CBE
63.86
42%
-67
- C2 -
-
1Q8W
1
KAPCA_BOVIN
A:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
189
Blastp_CBE
63.90
42%
-65
- C2 -
-
1CDK
2
KAPCA_PIG
B:
[33-339]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
F
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
Y
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
D
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
R
V
S
I
-------------------------------------
242
Blastp_CBE
63.87
42%
-72
- C2 -
-
4DG0
2
KAPCA_MOUSE
E:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
239
Blastp_CBE
63.87
42%
-66
- C2 -
-
4DH3
1
KAPCA_MOUSE
A:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
212
Blastp_CBE
63.87
42%
-68
- C2 -
-
3P0M
1
KAPCA_HUMAN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
261
Blastp_CBE
63.86
42%
-66
- C2 -
-
4IAF
1
KAPCA_MOUSE
A:
[39-341]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
341
Blastp_CBE
63.82
42%
-68
- C2 -
-
1XH5
3
KAPCA_BOVIN
A:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
213
Blastp_CBE
63.82
42%
-67
- C2 -
-
3OXT
1
KAPCA_HUMAN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
401
Blastp_CBE
63.77
42%
-67
- C2 -
-
1XH4
1
KAPCA_BOVIN
A:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
291
Blastp_CBE
63.78
39%
-31
- C2 -
-
5OL3
2
KAPCA_CRIGR
A:
[13-338]
--------------------------------------------------------------------------------------------------------------------
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
240
Blastp_CBE
63.79
42%
-66
- C2 -
-
4DH1
1
KAPCA_MOUSE
A:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
264
Blastp_CBE
63.78
42%
-70
- C2 -
-
3PVB
1
KAPCA_MOUSE
A:
[28-330]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
378
Blastp_CBE
63.74
38%
-58
- C2 -
-
4WB6
1
KAPCA_HUMAN
A:
[13-339]
-----------------------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
-----------------
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
R
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
R
V
S
I
-------------------------------------
196
Blastp_CBE
63.77
38%
-62
- C2 -
-
3AGL
1
KAPCA_HUMAN
B:
[15-336]
------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
-----------------
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
35
Blastp_CBE
63.74
50%
-17
- C2 -
-
3MVH
1
AKT1_HUMAN
A:
[7-338]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
-
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
K
A
---
T
---
G
---
R
-
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
-
K
-
D
E
V
A
H
T
L
T
E
-
N
R
V
--
L
Q
-
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
-
K
--
E
-
G
I
K
-
D
-
G
A
T
M
--
K
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
---
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
----
N
Q
D
H
----
E
K
----
L
F
E
L
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
-
G
--
S
--
E
-
D
A
K
E
--
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
--
E
E
F
T
-
A
Q
-
M
I
T
I
T
--
D
Q
D
D
S
M
E
-----------------------------
277
Blastp_CBE
63.68
39%
-66
- C2 -
-
6ERS
1
KAPCA_CRIGR
A:
[14-338]
---------------------------------------------------------------------------------------------------------------------
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
---
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
342
Blastp_CBE
63.69
42%
-67
- C2 -
-
1SVH
1
KAPCA_BOVIN
A:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
224
Blastp_CBE
63.68
42%
-67
- C2 -
-
4YXR
1
KAPCA_BOVIN
A:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
D
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
397
Blastp_CBE
63.65
42%
-69
- C2 -
-
3ZO1
7
KAPCA_BOVIN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
229
Blastp_CBE
63.61
42%
-67
- C2 -
-
1L3R
3
KAPCA_MOUSE
E:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
366
Blastp_CBE
63.59
42%
-65
- C2 -
-
1VEB
1
KAPCA_BOVIN
A:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
367
Blastp_CBE
63.54
42%
-69
- C2 -
-
1SVG
1
KAPCA_BOVIN
A:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
370
Blastp_CBE
63.55
42%
-67
- C2 -
-
1Q8U
3
KAPCA_BOVIN
A:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
257
Blastp_CBE
63.54
42%
-67
- C2 -
-
4IAZ
1
KAPCA_MOUSE
A:
[39-341]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
259
Blastp_CBE
63.51
42%
-71
- C2 -
-
4IAK
1
KAPCA_MOUSE
A:
[39-341]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
248
Blastp_CBE
63.51
42%
-66
- C2 -
-
3X2U
1
KAPCA_MOUSE
A:
[40-342]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
140
Blastp_CBE
63.52
42%
-64
- C2 -
-
3IDB
1
KAPCA_MOUSE
A:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
210
Blastp_CBE
63.51
42%
-69
- C2 -
-
4UJ1
2
KAPCA_HUMAN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
263
Blastp_CBE
63.50
42%
-65
- C2 -
-
4IAC
1
KAPCA_MOUSE
A:
[39-341]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
150
Blastp_CBE
63.49
42%
-71
- C2 -
-
1BKX
1
KAPCA_MOUSE
A:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
300
Blastp_CBE
63.47
39%
-62
- C2 -
-
5N3P
4
KAPCA_CRIGR
A:
[15-338]
----------------------------------------------------------------------------------------------------------------------
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
270
Blastp_CBE
63.43
39%
-66
- C2 -
-
6I2C
1
KAPCA_CRIGR
A:
[14-338]
---------------------------------------------------------------------------------------------------------------------
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
---
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
265
Blastp_CBE
63.45
42%
-67
- C2 -
-
3MVJ
1
KAPCA_HUMAN
E:
[54-356]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
251
Blastp_CBE
63.43
42%
-68
- C2 -
-
4XW6
1
KAPCA_MOUSE
A:
[39-341]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
135
Blastp_CBE
63.43
42%
-68
- C2 -
-
4HPT
1
KAPCA_MOUSE
E:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
250
Blastp_CBE
63.41
42%
-65
- C2 -
-
6E21
1
KAPCA_MOUSE
A:
[39-341]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
199
Blastp_CBE
63.39
42%
-69
- C2 -
-
1YDS
1
KAPCA_BOVIN
E:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
D
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
137
Blastp_CBE
63.39
42%
-68
- C2 -
-
3OW3
1
KAPCA_MOUSE
A:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
290
Blastp_CBE
63.38
39%
-65
- C2 -
-
5OT3
3
KAPCA_CRIGR
A:
[15-338]
----------------------------------------------------------------------------------------------------------------------
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
197
Blastp_CBE
63.37
38%
-62
- C2 -
-
3AGL
1
KAPCA_HUMAN
A:
[11-336]
--------------------------------------------------------------------------------------------------------------------
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
-----------------
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
371
Blastp_CBE
63.34
42%
-68
- C2 -
-
1Q8T
1
KAPCA_BOVIN
A:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
351
Blastp_CBE
63.30
42%
-70
- C2 -
-
2VO7
2
KAPCA_BOVIN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
432
Blastp_CBE
63.27
41%
-65
- C2 -
-
2UW3
1
KAPCA_BOVIN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
434
Blastp_CBE
63.31
41%
-67
- C2 -
-
2UVZ
1
KAPCA_BOVIN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
218
Blastp_CBE
63.30
42%
-64
- C2 -
-
3L9L
1
KAPCA_HUMAN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
339
Blastp_CBE
63.29
42%
-68
- C2 -
-
1XH8
1
KAPCA_BOVIN
A:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
394
Blastp_CBE
63.27
42%
-68
- C2 -
-
3ZO2
4
KAPCA_BOVIN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
214
Blastp_CBE
63.26
42%
-64
- C2 -
-
3OWP
1
KAPCA_HUMAN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
151
Blastp_CBE
63.25
42%
-68
- C2 -
-
1JBP
2
KAPCA_MOUSE
E:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
E
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
433
Blastp_CBE
63.19
41%
-65
- C2 -
-
2UW0
1
KAPCA_BOVIN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
419
Blastp_CBE
63.23
41%
-72
- C2 -
-
4C35
2
KAPCA_BOVIN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
Y
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
425
Blastp_CBE
63.17
41%
-61
- C2 -
-
2VO6
1
KAPCA_BOVIN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
403
Blastp_CBE
63.21
41%
-62
- C2 -
-
2VO0
4
KAPCA_BOVIN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
404
Blastp_CBE
63.19
41%
-64
- C2 -
-
4AXA
1
KAPCA_BOVIN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
258
Blastp_CBE
63.17
42%
-67
- C2 -
-
4IAY
1
KAPCA_MOUSE
A:
[39-341]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
235
Blastp_CBE
63.15
42%
-70
- C2 -
-
4HPU
2
KAPCA_MOUSE
E:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
139
Blastp_CBE
63.15
42%
-66
- C2 -
-
3IDC
1
KAPCA_MOUSE
A:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
255
Blastp_CBE
63.13
42%
-67
- C2 -
-
4IB1
1
KAPCA_MOUSE
A:
[39-341]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
202
Blastp_CBE
63.13
42%
-68
- C2 -
-
5UZK
1
KAPCA_HUMAN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
347
Blastp_CBE
63.12
42%
-69
- C2 -
-
6E99
1
KAPCA_BOVIN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
352
Blastp_CBE
63.10
42%
-70
- C2 -
-
2C1B
1
KAPCA_BOVIN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
89
Blastp_CBE
63.08
43%
-53
- C2 -
-
6ILZ
1
KPCI_HUMAN
A:
[11-344]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
---------
D
---
R
-
I
Y
A
M
K
V
V
K
K
E
L
V
N
D
-
D
-
E
D
I
D
W
V
Q
T
E
K
H
V
F
--
E
Q
-
A
S
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
-
G
H
I
K
L
T
D
Y
G
M
C
-
K
--
E
-
G
L
R
P
G
-
D
T
T
S
--
T
F
-
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
-----
D
---
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
D
I-----------
E
D
Y---
L
F
Q
V
I
-
L
E
--
K
Q
I
----
R
I
--
P
-----
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
-
G
-
C
HP
Q
--
T
-
G
F
A
D
--
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
--
S
Q
F
T
-
N
E
-
P
V
-----
Q
L
P
D
D
D
D
I
V
R
K
I
D
Q
S
--
E
F
E
G
F
E
Y
----
I
N
P
-----
234
Blastp_CBE
63.07
42%
-63
- C2 -
-
4WBB
1
KAPCA_MOUSE
B:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
408
Blastp_CBE
63.00
41%
-71
- C2 -
-
2JDV
1
KAPCA_BOVIN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
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H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
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K
L
E
F
S
F
K
D
N
S
N
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Y
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G
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R
--
I
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P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
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Y
L
H
S
-
L
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L
I
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P
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N
L
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Q
Q
-
G
Y
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D
F
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F
A
-
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-------
R
V
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K
G
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--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
254
Blastp_CBE
63.00
42%
-65
- C2 -
-
4IB3
1
KAPCA_MOUSE
A:
[39-341]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
413
Blastp_CBE
62.95
42%
-62
- C2 -
-
4WB7
1
DNJB1_HUMAN (first)
A:
[88-390]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
157
Blastp_CBE
63.00
42%
-65
- C2 -
-
6MM5
1
KAPCA_MOUSE
E:
[22-324]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
237
Blastp_CBE
62.98
42%
-66
- C2 -
-
4DH7
1
KAPCA_MOUSE
A:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
327
Blastp_CBE
62.97
42%
-68
- C2 -
-
4O21
1
KAPCA_MOUSE
A:
[25-327]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
377
Blastp_CBE
62.95
42%
-68
- C2 -
-
4WB5
1
KAPCA_HUMAN
A:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
373
Blastp_CBE
62.93
42%
-72
- C2 -
-
2GNL
1
KAPCA_BOVIN
A:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
I
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
K
V
A
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
561
HHSearch
62.91
48%
8
- C2 -
-
4L44
1
KS6B1_HUMAN
A:
[16-346]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
GAN
T
---
G
---
K
-
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
-
K
D
T
A
H
T
K
A
E
R
N
I
---
L
E
-
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
L
C
-
K
--
E
-
S
I
H
------
H
--
T
F
-
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
-----
G
---
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
T
----
G
E
N
R
----
K
K
----
T
I
D
K
I
-
L
K
--
C
K
L
----
N
L
--
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
-
G
-
A
--
G
--
P
G
D
A
G
E
--
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
E
E
D
V
S
Q
-
D
--
S
K
F
T
-
R
Q
-
T
-----------------
S
E
S
A
N
Q
V
F
L
G
F
A
Y
----
V
A
P
S
----
225
Blastp_CBE
62.90
42%
-67
- C2 -
-
3DNE
1
KAPCA_BOVIN
A:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
D
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
37
Blastp_CBE
62.90
50%
-14
- C2 -
-
3CQW
1
AKT1_HUMAN
A:
[6-340]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
-
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
K
A
---
T
---
G
---
R
-
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
-
K
-
D
E
V
A
H
T
L
T
E
-
N
R
V
--
L
Q
-
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
-
K
--
E
-
G
I
K
-
D
-
G
A
T
M
--
K
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
---
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
----
N
Q
D
H
----
E
K
----
L
F
E
L
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
-
G
--
S
--
E
-
D
A
K
E
--
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
--
E
E
F
T
-
A
Q
-
M
I
T
I
T
P
P
D
Q
D
D
S
M
E
C
V
D
S
-------------------------
217
Blastp_CBE
62.89
42%
-63
- C2 -
-
3L9L
1
KAPCA_HUMAN
B:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
190
Blastp_CBE
62.89
42%
-66
- C2 -
-
1CDK
2
KAPCA_PIG
A:
[33-339]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
F
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
Y
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
D
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
R
V
S
I
-------------------------------------
399
Blastp_CBE
62.88
42%
-68
- C2 -
-
3KKV
1
KAPCA_BOVIN
A:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
260
Blastp_CBE
62.87
42%
-66
- C2 -
-
4IAI
2
KAPCA_MOUSE
A:
[39-341]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
415
Blastp_CBE
62.86
41%
-73
- C2 -
-
4C38
4
KAPCA_BOVIN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
Y
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
346
Blastp_CBE
62.82
42%
-66
- C2 -
-
6E9L
1
KAPCA_BOVIN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
379
Blastp_CBE
62.85
42%
-67
- C2 -
-
4WB8
2
KAPCA_HUMAN
A:
[20-322]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
382
Blastp_CBE
62.80
41%
-66
- C2 -
-
1Q24
1
KAPCA_BOVIN
A:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
340
Blastp_CBE
62.82
42%
-66
- C2 -
-
1XH6
1
KAPCA_BOVIN
A:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
238
Blastp_CBE
62.80
42%
-64
- C2 -
-
4DH5
1
KAPCA_MOUSE
A:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
221
Blastp_CBE
62.79
42%
-63
- C2 -
-
6C0U
4
KAPCA_HUMAN
A:
[37-339]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
427
Blastp_CBE
62.73
41%
-66
- C2 -
-
2VNY
1
KAPCA_BOVIN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
418
Blastp_CBE
62.78
41%
-68
- C2 -
-
4C36
1
KAPCA_BOVIN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
Y
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
209
Blastp_CBE
62.73
42%
-65
- C2 -
-
4UJ2
2
KAPCA_HUMAN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
369
Blastp_CBE
62.69
42%
-70
- C2 -
-
1STC
1
KAPCA_BOVIN
E:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
185
Blastp_CBE
62.71
39%
-68
- C2 -
-
6F14
2
KAPCA_CRIGR
A:
[9-336]
------------------------------------------------------------------------------------------------------------------
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
-----
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
45
Blastp_CBE
62.71
50%
-16
- C2 -
-
3OW4
1
AKT1_HUMAN
B:
[9-339]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
K
A
---
T
---
G
---
R
-
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
-
K
-
D
E
V
A
H
T
L
T
E
-
N
R
V
--
L
Q
-
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
-
K
--
E
-
G
I
K
-
D
-
G
A
T
M
--
K
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
---
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
----
N
Q
D
H
----
E
K
----
L
F
E
L
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
-
G
--
S
--
E
-
D
A
K
E
--
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
--
E
E
F
T
-
A
Q
-
M
I
--
T
P
P
D
Q
D
D
S
M
E
C
V
D
S
-------------------------
253
Blastp_CBE
62.69
42%
-62
- C2 -
-
4XW4
1
KAPCA_MOUSE
A:
[39-341]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
141
Blastp_CBE
62.69
42%
-67
- C2 -
-
3FJQ
1
KAPCA_MOUSE
E:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
243
Blastp_CBE
62.66
42%
-66
- C2 -
-
2QCS
5
KAPCA_MOUSE
A:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
348
Blastp_CBE
62.64
42%
-67
- C2 -
-
4IE9
2
KAPCA_BOVIN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
222
Blastp_CBE
62.63
42%
-68
- C2 -
-
1RDQ
3
KAPCA_MOUSE
E:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
A
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
429
Blastp_CBE
62.62
41%
-66
- C2 -
-
2UW8
1
KAPCA_BOVIN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
430
Blastp_CBE
62.56
41%
-66
* C2 *
-
2UW6
1
KAPCA_BOVIN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
386
Blastp_CBE
62.57
41%
-66
- C2 -
-
2GNF
1
KAPCA_BOVIN
A:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
I
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
K
V
A
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
144
Blastp_CBE
62.61
42%
-67
- C2 -
-
1RE8
2
KAPCA_MOUSE
A:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
383
Blastp_CBE
62.60
41%
-68
- C2 -
-
4Z84
1
KAPCA_BOVIN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
232
Blastp_CBE
62.59
42%
-68
- C2 -
-
5JR7
1
KAPCA_MOUSE
C:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
155
Blastp_CBE
62.58
42%
-68
- C2 -
-
6MM6
1
KAPCA_MOUSE
E:
[22-339]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
384
Blastp_CBE
62.57
41%
-67
- C2 -
-
4Z83
2
KAPCA_BOVIN
E:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
420
Blastp_CBE
62.56
41%
-74
- C2 -
-
4C34
3
KAPCA_BOVIN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
Y
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
-
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
405
Blastp_CBE
62.53
41%
-66
- C2 -
-
2UW7
1
KAPCA_BOVIN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
227
Blastp_CBE
62.52
42%
-64
- C2 -
-
3FHI
1
KAPCA_MOUSE
A:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
A
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
416
Blastp_CBE
62.50
41%
-69
- C2 -
-
4C37
2
KAPCA_BOVIN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
Y
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
262
Blastp_CBE
62.46
42%
-65
- C2 -
-
4IAD
1
KAPCA_MOUSE
A:
[39-341]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
426
Blastp_CBE
62.42
41%
-66
- C2 -
-
2VO3
1
KAPCA_BOVIN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
219
Blastp_CBE
62.46
42%
-62
- C2 -
-
3AGM
1
KAPCA_HUMAN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
400
Blastp_CBE
62.45
42%
-66
- C2 -
-
3BWJ
2
KAPCA_BOVIN
A:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
191
Blastp_CBE
62.44
42%
-67
- C2 -
-
3QAM
1
KAPCA_MOUSE
E:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
A
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
153
Blastp_CBE
62.44
42%
-65
- C2 -
-
6MM7
9
KAPCA_MOUSE
D:
[22-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
396
Blastp_CBE
62.43
42%
-64
- C2 -
-
3ZO3
9
KAPCA_BOVIN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
414
Blastp_CBE
62.42
42%
-65
- C2 -
-
1XH7
1
KAPCA_BOVIN
A:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
409
Blastp_CBE
62.40
41%
-64
- C2 -
-
2JDT
1
KAPCA_BOVIN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
152
Blastp_CBE
62.39
42%
-76
- C2 -
-
6MM8
6
KAPCA_MOUSE
C:
[22-324]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
E
-
E
E
-
E
I
-----------------------------------------
246
Blastp_CBE
62.37
42%
-66
- C2 -
-
3X2W
1
KAPCA_MOUSE
A:
[40-342]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
38
Blastp_CBE
62.35
50%
-17
- C2 -
-
3CQU
1
AKT1_HUMAN
A:
[6-340]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
-
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
K
A
---
T
---
G
---
R
-
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
-
K
-
D
E
V
A
H
T
L
T
E
-
N
R
V
--
L
Q
-
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
-
K
--
E
-
G
I
K
-
D
-
G
A
T
M
--
K
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
---
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
----
N
Q
D
H
----
E
K
----
L
F
E
L
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
-
G
--
S
--
E
-
D
A
K
E
--
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
--
E
E
F
T
-
A
Q
-
M
I
T
I
T
P
P
D
Q
D
D
S
M
E
C
V
D
S
-------------------------
211
Blastp_CBE
62.34
42%
-67
- C2 -
-
3POO
2
KAPCA_HUMAN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
----
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
40
Blastp_CBE
62.31
50%
-13
- C2 -
-
4EKK
1
AKT1_HUMAN
B:
[9-338]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
K
A
---
T
---
G
---
R
-
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
-
K
-
D
E
V
A
H
T
L
T
E
-
N
R
V
--
L
Q
-
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
-
K
--
E
-
G
I
K
-
D
-
G
A
T
M
--
K
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
---
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
----
N
Q
D
H
----
E
K
----
L
F
E
L
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
-
G
--
S
--
E
-
D
A
K
E
--
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
--
E
E
F
T
-
A
Q
-
M
I
T
I
T
P
P
D
Q
D
D
S
-
E
C
V
D
S
-------------------------
256
Blastp_CBE
62.29
42%
-63
- C2 -
-
4IB0
1
KAPCA_MOUSE
A:
[39-341]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
147
Blastp_CBE
62.29
42%
-65
- C2 -
-
1ATP
1
KAPCA_MOUSE
E:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
83
Blastp_CBE
62.27
43%
-63
- C2 -
-
5LIH
3
KPCI_HUMAN
B:
[6-340]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
K
K
---
T
---
D
---
R
-
I
Y
A
M
K
V
V
K
K
E
L
-----------
V
Q
T
E
K
H
V
F
--
E
Q
-
A
S
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
-
G
H
I
K
L
T
D
Y
G
M
C
-
K
--
E
-
G
L
R
P
G
-
D
T
T
S
--
T
F
-
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
-----
D
---
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
D
-------
T
----
E
D
Y---
L
F
Q
V
I
-
L
E
--
K
Q
I
----
R
I
--
P
-----
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
-
G
-
C
HP
Q
--
T
-
G
F
A
D
--
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
--
S
Q
F
T
-
N
E
-
P
V
-----
Q
L
P
D
D
D
D
I
V
R
K
I
D
Q
S
--
E
F
E
G
F
E
Y
----
I
N
P
-----
252
Blastp_CBE
62.25
42%
-68
- C2 -
-
4XW5
1
KAPCA_MOUSE
A:
[39-341]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
428
Blastp_CBE
62.22
41%
-64
- C2 -
-
2VNW
1
KAPCA_BOVIN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
431
Blastp_CBE
62.15
41%
-66
- C2 -
-
2UW5
1
KAPCA_BOVIN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
565
HHSearch
62.14
35%
-62
- C2 -
-
6ED6
1
ROCK2_HUMAN
A:
[85-413]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
-
A
E
D
Y
D
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
H
K
A
---
S
---
Q
---
K
-
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
-
R
-
S
D
S
A
F
F
W
E
E
R
D
-
I
--
M
A
-
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
--
Y
-
D
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
L
I
H
R
D
V
K
P
D
N
M
L
L
D
K
H
-
G
H
L
K
L
A
D
F
G
T
C
-
M
--
K
-
M
D
E
T
G
M
V
H
C
D
--
T
A
-
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
------F--
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
Y
----
A
D
S
L
----
V
G
----
T
Y
S
K
I
-
M
D
--
H
K
N
SLCF
P
E
--
D
-----
A
E
I
S
K
H
A
K
N
L
I
C
A
F
L
T
D
R
E
V
R
LG
R
N
-
G
-
V
---------
E
E
--
I
R
Q
H
P
F
F
K
N
D
Q
---
W
H
W
D
N
I
R
E
T
A
A
P
V
V
P
E
L
S
S
D
I
D
S
S
N
F
D
--
D
I
---------
E
T
F
-
P
I
P
------
K
A
F
V
G
N
Q
L
P
F
I
G
F
T
Y
------------
46
Blastp_CBE
62.16
50%
-13
- C2 -
-
3OW4
1
AKT1_HUMAN
A:
[9-339]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
K
A
---
T
---
G
---
R
-
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
-
K
-
D
E
V
A
H
T
L
T
E
-
N
R
V
--
L
Q
-
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
-
K
--
E
-
G
I
K
-
D
-
G
A
T
M
--
K
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
---
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
----
N
Q
D
H
----
E
K
----
L
F
E
L
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
-
G
--
S
--
E
-
D
A
K
E
--
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
--
E
E
F
T
-
A
Q
-
M
I
--
T
P
P
D
Q
D
D
S
M
E
C
V
D
S
-------------------------
43
Blastp_CBE
62.16
50%
-18
- C2 -
-
3QKL
1
AKT1_HUMAN
A:
[9-339]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
K
A
---
T
---
G
---
R
-
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
-
K
-
D
E
V
A
H
T
L
T
E
-
N
R
V
--
L
Q
-
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
-
K
--
E
-
G
I
K
-
D
-
G
A
T
M
--
K
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
---
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
----
N
Q
D
H
----
E
K
----
L
F
E
L
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
-
G
--
S
--
E
-
D
A
K
E
--
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
--
E
E
F
T
-
A
Q
-
M
I
--
T
P
P
D
Q
D
D
S
M
E
C
V
D
S
-------------------------
108
Blastp_CBE
62.15
47%
-92
- C2 -
-
3PFQ
1
KPCB_RAT
A:
[293-638]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
L
T
D
F
N
F
L
M
V
L
G
K
G
-
S
F
G
K
V
M
L
S
E
R
K
G
---
T
---
D
---
E
-
L
Y
A
V
K
I
L
K
K
D
V
V
I
Q
-
D
-
D
D
V
E
C
T
M
V
E
K
R
V
L
--
A
L
-
P
G
K
P
P
F
L
T
Q
L
H
S
C
F
Q
T
M
D
R
L
Y
F
V
M
E
Y
V
N
G
G
D
L
M
Y
H
I
Q
Q
--
V
G
R
F
K
E
P
H
A
V
F
Y
A
A
E
I
A
I
G
L
F
F
L
Q
S
-
K
G
I
I
Y
R
D
L
K
L
D
N
V
M
L
D
S
E
-
G
H
I
K
I
A
D
F
G
M
C
-
K
--
E
-
N
I
-
W
D
-
G
V
T
T
--
K
F
-
C
G
T
P
D
Y
I
A
P
E
I
I
A
Y
Q
-----
P
---
Y
G
K
S
V
D
W
W
A
F
G
V
L
L
Y
E
M
L
A
G
Q
-
A
P
F
E
----
G
E
D
E
----
D
E
----
L
F
Q
S
I
-
M
E
--
H
N
V
----
A
Y
--
P
-----
K
S
M
S
K
E
A
V
A
I
C
K
G
L
M
T
K
H
P
G
K
--
R
L
-
G
-
C
--
G
P-
E
-
G
E
R
D
--
I
K
E
H
A
F
F
R
Y
I
D
---
W
E
K
L
E
R
K
E
I
Q
P
P
Y
K
P
K
A
S
G
R
N
-
A
E
N
F
D
--
R
F
F
T
-
R
H
-
P
------------------------------------------
36
Blastp_CBE
62.14
50%
-18
- C2 -
-
3MV5
1
AKT1_HUMAN
A:
[6-339]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
-
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
K
A
---
T
---
G
---
R
-
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
-
K
-
D
E
V
A
H
T
L
T
E
-
N
R
V
--
L
Q
-
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
-
K
--
E
-
G
I
K
-
D
-
G
A
T
M
--
K
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
---
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
----
N
Q
D
H
----
E
K
----
L
F
E
L
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
-
G
--
S
--
E
-
D
A
K
E
--
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
--
E
E
F
T
-
A
Q
-
M
I
T
I
T
P
P
D
Q
D
D
S
M
E
C
----------------------------
345
Blastp_CBE
62.09
42%
-62
- C2 -
-
3L9M
1
KAPCA_HUMAN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
412
Blastp_CBE
61.95
42%
-63
- C2 -
-
4WB7
1
KAPCA_HUMAN
B:
[88-390]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
201
Blastp_CBE
62.03
42%
-72
- C2 -
-
3QAL
1
KAPCA_MOUSE
E:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
A
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
372
Blastp_CBE
62.00
42%
-73
- C2 -
-
2QUR
1
KAPCA_MOUSE
A:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
P
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
A
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
407
Blastp_CBE
61.95
41%
-66
- C2 -
-
2UVX
1
KAPCA_BOVIN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
128
Blastp_CBE
61.95
42%
-63
- C2 -
-
3O7L
2
KAPCA_MOUSE
B:
[33-343]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
----
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
I
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
I
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
R
V
S
I
-------------------------------------
388
Blastp_CBE
61.85
41%
-68
- C2 -
-
2GNH
2
KAPCA_BOVIN
A:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
I
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
K
V
A
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
44
Blastp_CBE
61.78
50%
-25
- C2 -
-
3QKK
1
AKT1_HUMAN
A:
[9-324]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
K
A
---
T
---
G
---
R
-
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
-
K
-
D
E
V
A
H
T
L
T
E
-
N
R
V
--
L
Q
-
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
-
K
--
E
-
G
I
K
-
D
-
G
A
T
M
--
K
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
---
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
----
N
Q
D
H
----
E
K
----
L
F
E
L
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
-
G
--
S
--
E
-
D
A
K
E
--
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
--
E
E
F
T
-
A
Q
-
M
I
T
I
T
--------
E
C
V
D
S
-------------------------
79
Blastp_CBE
61.71
44%
-77
- C2 -
-
4RA4
1
KPCA_HUMAN
A:
[15-344]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
V
K
-
L
T
D
F
N
F
L
M
V
L
G
K
G
-
S
F
G
K
V
M
L
A
D
R
K
G
---
T
---
E
---
E
-
L
Y
A
I
K
I
L
K
K
D
V
V
I
Q
-
D
-
D
D
V
E
C
T
M
V
E
K
R
V
L
--
A
L
-
L
D
K
P
P
F
L
T
Q
L
H
S
C
F
Q
T
V
D
R
L
Y
F
V
M
E
Y
V
N
G
G
D
L
M
Y
H
I
Q
Q
--
V
G
K
F
K
E
P
Q
A
V
F
Y
A
A
E
I
S
I
G
L
F
F
L
H
K
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
M
L
D
S
E
-
G
H
I
K
I
A
D
F
G
M
C
-
K
--
E
-
H
M
-
M
D
-
G
V
T
T
--
R
F
-
C
G
T
P
D
Y
I
A
P
E
I
I
A
Y
Q
-----
P
---
Y
G
K
S
V
D
W
W
A
Y
G
V
L
L
Y
E
M
L
A
G
Q
-
P
P
F
D
----
G
E
D
E
----
D
E
----
L
F
Q
S
I
-
M
E
--
H
N
V
----
S
Y
--
P
-----
K
S
L
S
K
E
A
V
S
I
C
K
G
L
M
T
K
H
P
A
K
--
R
L
-
G
-
C
--
G
P-
E
-
G
E
R
D
--
V
R
E
H
A
F
F
R
R
I
D
---
W
E
K
L
E
N
R
E
I
Q
P
P
F
K
P
K
V
------------------
Q
-
P
V
------
L
P
P
D
Q
L
V
I
A
N
I
D
Q
S
--
D
F
E
G
F
Y
V
----
N
P
------
435
Blastp_CBE
61.69
41%
-63
- C2 -
-
2UVY
1
KAPCA_BOVIN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
343
Blastp_CBE
61.67
42%
-66
- C2 -
-
3L9N
1
KAPCA_HUMAN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
---
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
228
Blastp_CBE
61.64
42%
-66
- C2 -
-
3TNQ
1
KAPCA_MOUSE
B:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
42
Blastp_CBE
61.63
50%
-22
- C2 -
-
3QKM
1
AKT1_HUMAN
A:
[9-324]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
K
A
---
T
---
G
---
R
-
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
-
K
-
D
E
V
A
H
T
L
T
E
-
N
R
V
--
L
Q
-
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
-
K
--
E
-
G
I
K
-
D
-
G
A
T
M
--
K
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
---
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
----
N
Q
D
H
----
E
K
----
L
F
E
L
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
-
G
--
S
--
E
-
D
A
K
E
--
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
--
E
E
F
T
-
A
Q
-
M
I
T
I
T
P
P
-----
M
E
C
V
D
S
-------------------------
395
Blastp_CBE
61.57
42%
-65
- C2 -
-
5VHB
1
KAPCA_BOVIN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
387
Blastp_CBE
61.55
41%
-64
- C2 -
-
2GNI
1
KAPCA_BOVIN
A:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
I
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
K
V
A
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
374
Blastp_CBE
61.51
42%
-66
- C2 -
-
2GNJ
1
KAPCA_BOVIN
A:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
I
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
K
V
A
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
452
Blastp_CBE
61.48
41%
-102
- C2 -
-
5LVP
1
PDPK1_HUMAN
C:
[33-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
-----------
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
G
L
----
I
F
A
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
41
Blastp_CBE
61.46
50%
-11
- C2 -
-
4EKK
1
AKT1_HUMAN
A:
[9-338]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
K
A
---
T
---
G
---
R
-
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
-
K
-
D
E
V
A
H
T
L
T
E
-
N
R
V
--
L
Q
-
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
-
K
--
E
-
G
I
K
-
D
-
G
A
T
M
--
K
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
---
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
----
N
Q
D
H
----
E
K
----
L
F
E
L
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
-
G
--
S
--
E
-
D
A
K
E
--
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
--
E
E
F
T
-
A
Q
-
M
I
T
I
T
P
P
D
Q
D
D
S
-
E
C
V
D
S
-------------------------
406
Blastp_CBE
61.39
41%
-59
- C2 -
-
2UW4
1
KAPCA_BOVIN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
-
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
344
Blastp_CBE
61.28
42%
-62
- C2 -
-
3L9M
1
KAPCA_HUMAN
B:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
94
Blastp_CBE
61.25
43%
-66
- C2 -
-
5LI1
2
KPCI_HUMAN
A:
[11-345]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
K
K
---
T
---
D
---
R
-
I
Y
A
M
K
V
V
K
K
E
L
V
N
D
-
D
-
E
D
I
D
W
V
Q
T
E
K
H
V
F
--
E
Q
-
A
S
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
--
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
-
G
H
I
K
L
T
D
Y
G
M
C
-
K
--
E
-
G
L
R
P
G
-
D
T
T
S
--
T
F
-
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
-----
D
---
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
D
I------
T
----
E
D
Y---
L
F
Q
V
I
-
L
E
--
K
Q
I
----
R
I
--------
P
R
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
-
G
-
C
HP
Q
--
T
-
G
F
A
D
--
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
--
S
Q
F
T
-
N
E
-
P
V
-----
Q
L
P
D
D
D
D
I
V
R
K
I
D
Q
S
--
E
F
E
G
F
E
Y
----
I
N
P
-----
47
Blastp_CBE
61.19
50%
-16
- C2 -
-
3OCB
1
AKT1_HUMAN
B:
[9-339]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
K
A
---
T
---
G
---
R
-
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
-
K
-
D
E
V
A
H
T
L
T
E
-
N
R
V
--
L
Q
-
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
-
K
--
E
-
G
I
K
-
D
-
G
A
T
M
--
K
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
---
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
----
N
Q
D
H
----
E
K
----
L
F
E
L
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
-
G
--
S
--
E
-
D
A
K
E
--
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
--
E
E
F
T
-
A
Q
-
M
I
T
I
T
P
P
D
Q
D
D
S
M
E
C
V
D
S
-------------------------
567
Fugue
61.12
30%
35
- C2 -
-
2ACX
1
GRK6_HUMAN
A:
[14-532]
KARKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERNPIGRLLFREFCATRPELSRCVA
F
L
D
G
V
A
E
Y
E
V
T
P
D
D
K
R
K
A
C
G
R
N
L
T
-
Q
N
F
L
S
H
T
G
P
D
L
I
P
E
V
PR
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
K
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
FNRF
L
Q
W
K
W
L
E
R
Q
P
V
T
-
K
N
T
F
R
Q
Y
R
V
L
G
K
G
-
G
F
G
E
V
C
A
C
Q
V
R
A
---
T
---
G
---
K
-
M
Y
A
C
K
K
L
E
K
K
R
I
K
K
-
R
-
K
G
E
A
M
A
L
N
E
K
Q
I
L
--
E
K
--
V
N
S
R
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
MG
Q
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
-
G
H
I
R
I
S
D
L
G
L
A
-
V
--
H
--
V
P
E
G
-
Q
T
I
K
--
G
R
-
V
G
T
V
G
Y
M
A
P
E
V
V
K
N
E
-----
R
---
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
-
S
P
F
Q
----
Q
R
K
K
KIKR
E
E
----
V
E
R
L
V
-
K
E
--
V
P
E
----
E
Y
--
S
-----
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
--
R
L
-
G
-
C
--
R
G-
G
-
S
A
R
E
--
V
K
E
H
P
L
F
K
K
L
N
---
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
-
E
P
T
D
--
Q
D
F
Y
-
Q
K
-
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
------
E
C
F
Q
E
L
N
V
----
F
G
L
D
G
S
--
48
Blastp_CBE
61.10
50%
-18
- C2 -
-
3OCB
1
AKT1_HUMAN
A:
[9-339]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
K
A
---
T
---
G
---
R
-
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
-
K
-
D
E
V
A
H
T
L
T
E
-
N
R
V
--
L
Q
-
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
-
K
--
E
-
G
I
K
-
D
-
G
A
T
M
--
K
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
---
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
----
N
Q
D
H
----
E
K
----
L
F
E
L
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
-
G
--
S
--
E
-
D
A
K
E
--
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
--
E
E
F
T
-
A
Q
-
M
I
----
P
D
Q
D
D
S
M
E
C
V
D
S
-------------------------
350
Blastp_CBE
61.05
42%
-60
- C2 -
-
3AG9
1
KAPCA_BOVIN
B:
[34-351]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
------------------------------------------
49
Blastp_CBE
61.05
50%
-25
- C2 -
-
4GV1
5
AKT1_HUMAN
A:
[8-323]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
K
A
---
T
---
G
---
R
-
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
-
K
-
D
E
V
A
H
T
L
T
E
-
N
R
V
--
L
Q
-
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
-
K
--
E
-
G
I
K
-
D
-
G
A
T
M
--
K
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
---
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
----
N
Q
D
H
----
E
K
----
L
F
E
L
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
-
G
--
S
--
E
-
D
A
K
E
--
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
--
E
E
F
T
-
A
Q
-
M
I
T
I
T
P
P
-----
M
E
C
V
D
S
-------------------------
443
Blastp_CBE
60.79
41%
-93
- C2 -
-
2PE2
9
PDPK1_HUMAN
A:
[5-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-
P
E
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
------------
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
Y
L
----
I
F
Q
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
39
Blastp_CBE
60.79
50%
-20
- C2 -
-
4EKL
1
AKT1_HUMAN
A:
[9-324]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
K
A
---
T
---
G
---
R
-
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
-
K
-
D
E
V
A
H
T
L
T
E
-
N
R
V
--
L
Q
-
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
-
K
--
E
-
G
I
K
-
D
-
G
A
T
M
--
K
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
---
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
----
N
Q
D
H
----
E
K
----
L
F
E
L
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
-
G
--
S
--
E
-
D
A
K
E
--
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
--
E
E
F
T
-
A
Q
-
M
I
T
I
T
P
P
-----
M
E
C
V
D
S
-------------------------
497
Blastp_CBE
60.78
41%
-95
- C2 -
-
3QD3
3
PDPK1_HUMAN
A:
[34-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
-----------
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
Y
L
----
I
F
Q
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
449
Blastp_CBE
60.71
41%
-92
- C2 -
-
3NUS
5
PDPK1_HUMAN
A:
[6-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-
P
E
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
-----------
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
Y
L
----
I
F
Q
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
34
Blastp_CBE
60.68
50%
-23
- C2 -
-
6CCY
1
AKT1_HUMAN
A:
[8-337]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
K
A
---
T
---
G
---
R
-
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
-
K
-
D
E
V
A
H
T
L
T
E
S
R
V
L
---
Q
-
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
-
K
--
E
-
G
I
K
-
D
-
G
A
T
M
--
K
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
---
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
----
N
Q
D
H
----
E
K
----
L
F
E
L
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
-
G
-
G
--
G
P-
S
-
D
A
K
E
--
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
--
E
E
F
T
-
A
Q
-
M
I
T
I
T
P
----------------
Q
E
M
F
R
D
F
D
Y
------------
143
Blastp_CBE
60.55
42%
-69
- C2 -
-
1REJ
1
KAPCA_MOUSE
A:
[33-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
S
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
440
Blastp_CBE
60.48
42%
-26
- C2 -
-
4OTG
1
A:
[13-339]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
L
A
V
L
G
R
G
-
H
F
G
K
V
L
L
S
E
F
R
P
---
S
---
G
---
E
-
L
F
A
I
K
A
L
K
K
G
D
I
V
A
-
R
-
D
E
V
E
S
L
M
C
E
K
R
I
L
AA
V
T
-
S
A
G
H
P
F
L
V
N
L
F
G
C
F
Q
T
P
E
H
V
C
F
V
M
E
Y
S
A
G
G
D
L
M
L
H
I
H
S
--
D
-
V
F
S
E
P
R
A
I
F
Y
S
A
C
V
V
L
G
L
Q
F
L
H
E
-
H
K
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
T
E
-
G
Y
V
K
I
A
D
F
G
L
C
-
K
--
E
-
G
M
G
Y
G
-
D
R
T
S
--
T
F
-
C
G
T
P
E
F
L
A
P
E
V
L
T
D
T
-----
S
---
Y
T
R
A
V
D
W
W
G
L
G
V
L
L
Y
E
M
L
V
G
E
-
S
P
F
P
----
G
D
D
E
----
E
E
----
V
F
D
S
I
-
V
N
--
D
E
V
----
R
Y
--
P
-----
R
F
L
S
A
E
A
I
G
I
M
R
R
L
L
R
R
N
P
E
R
--
R
L
-
G
-
S
--
S
--
E
R
D
A
E
D
--
V
K
K
Q
P
F
F
R
T
L
G
---
W
E
A
L
L
A
R
R
L
P
P
P
F
V
P
T
L
S
G
R
T
D
V
S
N
F
D
--
E
E
F
T
-
G
E
--------------------------------------------
446
Blastp_CBE
60.41
41%
-96
- C2 -
-
1Z5M
4
PDPK1_HUMAN
A:
[5-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-
P
E
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
------------
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
Y
L
----
I
F
Q
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
448
Blastp_CBE
60.39
41%
-90
- C2 -
-
3NUU
5
PDPK1_HUMAN
A:
[6-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-
P
E
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
-----------
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
Y
L
----
I
F
Q
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
424
Blastp_CBE
60.34
41%
-70
- C2 -
-
6FRX
1
KAPCA_HUMAN
A:
[34-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
R
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
Q
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
K
V
A
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
-----
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
244
Blastp_CBE
60.04
42%
-70
- C2 -
-
5VIB
1
KAPCA_BOVIN
A:
[34-351]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
---------
F
D
---
D
Y
E
-
E
E
-
E
I
R
----------------------------------------
560
HHSearch
59.90
41%
-38
- C2 -
-
4OTH
1
A:
[9-339]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
-
L
E
D
F
K
F
L
A
V
L
G
R
G
-
H
F
G
K
V
L
L
S
E
F
R
P
---
S
---
G
---
E
-
L
F
A
I
K
A
L
K
K
G
D
I
V
A
-
R
-
D
E
V
E
S
L
M
C
E
K
R
I
L
AA
V
T
-
S
A
G
H
P
F
L
V
N
L
F
G
C
F
Q
T
P
E
H
V
C
F
V
M
E
Y
S
A
G
G
D
L
M
L
H
I
H
S
---
D
V
F
S
E
P
R
A
I
F
Y
S
A
C
V
V
L
G
L
Q
F
L
H
E
-
H
K
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
T
E
-
G
Y
V
K
I
A
D
F
G
L
C
-
K
--------------------------------------------
T
R
A
V
D
W
W
G
L
G
V
L
L
Y
E
M
L
V
G
E
-
S
P
F
P
----
G
D
D
E
----
E
E
----
V
F
D
S
I
-
V
N
--
D
E
V
----
R
Y
--
P
-----
R
F
L
S
A
E
A
I
G
I
M
R
R
L
L
R
R
N
P
E
R
--
R
L
-
G
-
S
--
S
--
E
R
D
A
E
D
--
V
K
K
Q
P
F
F
R
T
L
G
---
W
E
A
L
L
A
R
R
L
P
P
P
F
V
P
T
L
S
G
R
T
D
V
S
N
F
D
--
E
E
F
T
-
G
E
-
A
P
T
L
S
P
P
R
D
A
R
-----
P
L
T
A
A
E
Q
A
A
F
L
D
F
D
F
----
V
A
G
-----
504
Blastp_CBE
59.86
41%
-95
- C2 -
-
3RWP
5
PDPK1_HUMAN
A:
[33-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
-----------
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
Y
L
----
I
F
Q
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
503
Blastp_CBE
59.85
41%
-96
- C2 -
-
3IOP
1
PDPK1_HUMAN
A:
[34-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
-----------
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
Y
L
----
I
F
Q
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
444
Blastp_CBE
59.82
41%
-92
- C2 -
-
2PE1
5
PDPK1_HUMAN
A:
[5-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-
P
E
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
------------
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
Y
L
----
I
F
Q
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
500
Blastp_CBE
59.73
41%
-97
- C2 -
-
3QCX
6
PDPK1_HUMAN
A:
[34-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
-----------
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
Y
L
----
I
F
Q
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
447
Blastp_CBE
59.71
41%
-89
- C2 -
-
3NUY
5
PDPK1_HUMAN
A:
[6-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-
P
E
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
-----------
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
Y
L
----
I
F
Q
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
507
Blastp_CBE
59.70
41%
-93
- C2 -
-
3NUN
5
PDPK1_HUMAN
A:
[15-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
-----------
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
Y
L
----
I
F
Q
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
486
Blastp_CBE
59.64
41%
-95
- C2 -
-
1UU3
9
PDPK1_HUMAN
A:
[31-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
------------
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
Y
L
----
I
F
Q
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
501
Blastp_CBE
59.63
41%
-97
- C2 -
-
3QCS
5
PDPK1_HUMAN
A:
[34-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
-----------
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
Y
L
----
I
F
Q
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
502
Blastp_CBE
59.57
41%
-96
- C2 -
-
3QCQ
5
PDPK1_HUMAN
A:
[34-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
-----------
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
Y
L
----
I
F
Q
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
450
Blastp_CBE
59.54
41%
-88
- C2 -
-
1UU9
8
PDPK1_HUMAN
A:
[7-285]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-
P
E
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
-----------
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
Y
L
----
I
F
Q
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
574
Fugue
59.29
39%
17
- C2 -
-
1CDK
2
KAPCA_PIG
A:
[8-350]
--------------------------------------------------------------------------------------------------------------------------
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
----
P
A
Q
N
T
A
------H
L
D
Q
F
E
R
I
K
T
L
G
T
-G
S
F
G
R
V
M
L
V
K
H
K
E
---
T
G------
N
-
H
F
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
--
Q
A
V--
N
F
P
F
L
V
K
L
E
Y
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I--
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
-Q
G
Y
I
Q
V
T
D
F
G
F
A
-
K
--
R
-
V
-
K
---
G
--
R
TW
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
-KGY-------
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-Y
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
PS-------
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
-
N
L-
K
--
D
-
G
V
N
D
--
I
K
N
H
K
W
F
A
---TTD
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
--
D
Y
E
E
-
E
E
-
I
R
V
S
I
--------
N
E
K
C
G
-----
K
E
F
S
E
F
--------------
58
Blastp_CBE
59.26
46%
-4
- C2 -
-
4L42
1
KS6B1_HUMAN
A:
[13-342]
------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
---
I
R
-
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
---
G
---
A
NTG
K
-
I
F
A
M
K
V
L
K
K
A
M
I
V
R
-
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
---
E
-
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
L
C
-
K
--
E
-
S
I
H
D
G
-
T
V
T
H
--
T
F
-
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
-----
G
---
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
T
----
G
E
N
R
----
K
K
----
T
I
D
K
I
-
L
K
--
C
K
L
----
N
L
--
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
-
G
-
A
--
G
P-
G
-
D
A
G
E
--
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
----------------------------------------------
E
M
F
R
D
F
E
Y
------------
487
Blastp_CBE
59.25
41%
-98
- C2 -
-
1OKZ
7
PDPK1_HUMAN
A:
[31-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
-----------
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
Y
L
----
I
F
Q
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
498
Blastp_CBE
59.15
41%
-96
- C2 -
-
3QD0
6
PDPK1_HUMAN
A:
[34-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
---------------
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
Y
L
----
I
F
Q
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
509
Blastp_CBE
59.11
41%
-94
- C2 -
-
3NAY
1
PDPK1_HUMAN
A:
[30-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
--------
A
--
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
Y
L
----
I
F
Q
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
445
Blastp_CBE
59.10
41%
-93
- C2 -
-
2PE0
4
PDPK1_HUMAN
A:
[5-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-
P
E
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
------------
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
Y
L
----
I
F
Q
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
493
Blastp_CBE
59.06
41%
-91
- C2 -
-
2XCH
7
PDPK1_HUMAN
A:
[31-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
--------
A
--
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
Y
L
----
I
F
Q
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
483
Blastp_CBE
58.97
41%
-94
- C2 -
-
3H9O
1
PDPK1_HUMAN
A:
[33-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
-----------
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
Y
L
----
I
F
Q
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
68
Blastp_CBE
58.89
47%
-8
- C2 -
-
3WE4
1
KS6B1_HUMAN
A:
[15-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
I
R
-
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
---
G
---
A
NTG
K
-
I
F
A
M
K
V
L
K
K
A
M
I
V
R
-
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
---
E
-
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
L
C
-
K
--
E
-
S
I
-
H
D
---
V
T
--
H
F
-
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
-----
G
---
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
T
----
G
E
N
R
----
K
K
----
T
I
D
K
I
-
L
K
--
C
K
L
----
N
L
--
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
-
G
-
A
--
G
P-
G
-
D
A
G
E
--
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
--------------------------------------------------------------
505
Blastp_CBE
58.77
41%
-96
- C2 -
-
3SC1
3
PDPK1_HUMAN
A:
[33-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
--------
A
--
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
Y
L
----
I
F
Q
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
484
Blastp_CBE
58.74
41%
-96
- C2 -
-
1UU8
7
PDPK1_HUMAN
A:
[31-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
--------
A
--
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
Y
L
----
I
F
Q
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
499
Blastp_CBE
58.67
41%
-95
- C2 -
-
3QCY
5
PDPK1_HUMAN
A:
[34-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
--------------
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
Y
L
----
I
F
Q
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
65
Blastp_CBE
58.62
47%
-6
- C2 -
-
3WF7
2
KS6B1_HUMAN
A:
[13-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
K
---
I
R
-
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
---
G
---
A
NTG
K
-
I
F
A
M
K
V
L
K
K
A
M
I
V
R
-
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
---
E
-
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
L
C
-
K
--
E
-
S
I
-
H
D
---
V
T
--
H
F
-
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
-----
G
---
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
T
----
G
E
N
R
----
K
K
----
T
I
D
K
I
-
L
K
--
C
K
L
----
N
L
--
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
-
G
-
A
--
G
P-
G
-
D
A
G
E
--
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
--------------------------------------------------------------
70
Blastp_CBE
58.46
49%
-5
- C2 -
-
4L3L
1
KS6B1_HUMAN
A:
[14-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
I
R
-
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
---
G
---
A
NTG
K
-
I
F
A
M
K
V
L
K
K
A
M
I
V
R
-
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
---
E
-
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
L
C
-
K
--
E
-
S
I
H
D
G
-
T
V
T
H
--
T
F
-
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
-----
G
---
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
T
----
G
E
N
R
----
K
K
----
T
I
D
K
I
-
L
K
--
C
K
L
----
N
L
--
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
-
G
-
A
--
G
P-
G
-
D
A
G
E
--
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----------------------------------------------------------------
71
Blastp_CBE
58.45
49%
-6
- C2 -
-
4L3J
1
KS6B1_HUMAN
A:
[14-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
I
R
-
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
---
G
---
A
NTG
K
-
I
F
A
M
K
V
L
K
K
A
M
I
V
R
-
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
---
E
-
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
L
C
-
K
--
E
-
S
I
H
D
G
-
T
V
T
H
--
T
F
-
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
-----
G
---
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
T
----
G
E
N
R
----
K
K
----
T
I
D
K
I
-
L
K
--
C
K
L
----
N
L
--
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
-
G
-
A
--
G
P-
G
-
D
A
G
E
--
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----------------------------------------------------------------
496
Blastp_CBE
58.41
41%
-97
- C2 -
-
3QD4
1
PDPK1_HUMAN
A:
[34-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
---------------
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
Y
L
----
I
F
Q
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
102
Blastp_CBE
58.40
47%
6
- C2 -
-
4NW6
1
KS6A3_HUMAN
A:
[27-323]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
-
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
K
I
S
GSD
A
---
R
---
Q
-
L
Y
A
M
K
V
L
-
K
K
A
T
L
K
-
V
-
R
D
R
V
R
T
K
M
E
R
D
I
L
--
V
E
--
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
-
G
H
I
K
L
T
D
F
G
L
S
-
K
--
E
-
S
I
D
H
E
-
K
K
A
Y
--
S
F
-
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
-----
G
---
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
Q
----
G
K
D
R
----
K
E
----
T
M
T
M
I
-
L
K
--
A
K
L
----
G
M
--
P
-----
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
-
G
-
A
--
G
P-
D
-
G
V
E
E
--
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------
T
F
Y
F
D
--
P
--------------------------------------------------
512
Blastp_CBE
58.29
40%
-89
- C2 -
-
2XCK
5
PDPK1_HUMAN
A:
[31-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
T
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
--------
A
--
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
Y
L
----
I
F
Q
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
488
Blastp_CBE
58.28
41%
-94
- C2 -
-
1OKY
4
PDPK1_HUMAN
A:
[31-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
P
E
S
--------
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
Y
L
----
I
F
Q
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
508
Blastp_CBE
58.01
41%
-97
- C2 -
-
3NAY
1
PDPK1_HUMAN
B:
[30-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
--------
A
--
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
Y
L
----
I
F
Q
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
103
Blastp_CBE
57.82
47%
4
- C2 -
-
4NW5
1
KS6A3_HUMAN
A:
[27-323]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
-
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
K
I
S
GSD
A
---
R
---
Q
-
L
Y
A
M
K
V
L
-
K
K
A
T
L
K
-
V
-
R
D
R
V
R
T
K
M
E
R
D
I
L
--
V
E
--
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
-
G
H
I
K
L
T
D
F
G
L
S
-
K
--
E
-
S
I
D
H
E
-
K
K
A
Y
--
S
F
-
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
-----
G
---
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
Q
----
G
K
D
R
----
K
E
----
T
M
T
M
I
-
L
K
--
A
K
L
----
G
M
--
P
-----
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
-
G
-
A
--
G
P-
D
-
G
V
E
E
--
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------
T
F
Y
F
D
--
P
--------------------------------------------------
101
Blastp_CBE
57.13
47%
-4
- C2 -
-
5D9L
2
KS6A3_HUMAN
A:
[27-323]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
-
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
K
I
S
GSD
A
---
R
---
Q
-
L
Y
A
M
K
V
L
-
K
K
A
T
L
K
-
V
-
R
D
R
V
R
T
K
M
E
R
D
I
L
--
V
E
--
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
-
G
H
I
K
L
T
D
F
G
L
S
-
K
--
E
-----------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
-----
G
---
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
Q
----
G
K
D
R
----
K
E
----
T
M
T
M
I
-
L
K
--
A
K
L
----
G
M
--
P
-----
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
-
G
-
A
--
G
P-
D
-
G
V
E
E
--
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
T
G
R
P
E
D
T
F
Y
F
D
--
P
--------------------------------------------------
439
Blastp_CBE
57.04
42%
-43
- C2 -
-
4OTH
1
A:
[13-310]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
L
A
V
L
G
R
G
-
H
F
G
K
V
L
L
S
E
F
R
P
---
S
---
G
---
E
-
L
F
A
I
K
A
L
K
K
G
D
I
V
A
-
R
-
D
E
V
E
S
L
M
C
E
K
R
I
L
AA
V
T
-
S
A
G
H
P
F
L
V
N
L
F
G
C
F
Q
T
P
E
H
V
C
F
V
M
E
Y
S
A
G
G
D
L
M
L
H
I
H
S
--
D
-
V
F
S
E
P
R
A
I
F
Y
S
A
C
V
V
L
G
L
Q
F
L
H
E
-
H
K
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
T
E
-
G
Y
V
K
I
A
D
F
G
L
C
-
K
--------------------------------------------
T
R
A
V
D
W
W
G
L
G
V
L
L
Y
E
M
L
V
G
E
-
S
P
F
P
----
G
D
D
E
----
E
E
----
V
F
D
S
I
-
V
N
--
D
E
V
----
R
Y
--
P
-----
R
F
L
S
A
E
A
I
G
I
M
R
R
L
L
R
R
N
P
E
R
--
R
L
-
G
-
S
--
S
--
E
R
D
A
E
D
--
V
K
K
Q
P
F
F
R
T
L
G
---
W
E
A
L
L
A
R
R
L
P
P
P
F
V
P
T
L
S
G
R
T
D
V
S
N
F
D
--
E
E
F
T
-
G
E
--------------------------------------------
98
Blastp_CBE
56.88
48%
-9
- C2 -
-
5D9K
2
KS6A3_HUMAN
A:
[27-323]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
-
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
K
I
S
GSD
A
---
R
---
Q
-
L
Y
A
M
K
V
L
-
K
K
A
T
L
K
-
V
-
R
D
R
V
R
T
K
M
E
R
D
I
L
--
V
E
--
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
-
G
H
I
K
L
T
D
F
G
L
S
-
K
-------------------
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
-----
G
---
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
Q
----
G
K
D
R
----
K
E
----
T
M
T
M
I
-
L
K
--
A
K
L
----
G
M
--
P
-----
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
-
G
-
A
--
G
P-
D
-
G
V
E
E
--
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
------
T
F
Y
F
D
--
P
--------------------------------------------------
104
Blastp_CBE
56.61
47%
6
- C2 -
-
4NUS
1
KS6A3_HUMAN
A:
[27-323]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
-
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
K
I
S
GSD
A
---
R
---
Q
-
L
Y
A
M
K
V
L
-
K
K
A
T
L
K
-
V
-
R
D
R
V
R
T
K
M
E
R
D
I
L
--
V
E
--
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
-
G
H
I
K
L
T
D
F
G
L
S
-
K
--
E
-
S
I
D
H
E
-
K
K
A
Y
--
S
F
-
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
-----
G
---
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
Q
----
G
K
D
R
----
K
E
----
T
M
T
M
I
-
L
K
--
A
K
L
----
G
M
--
P
-----
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
-
G
-
A
--
G
P-
D
-
G
V
E
E
--
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
------
T
F
Y
F
D
--
P
--------------------------------------------------
245
Blastp_CBE
56.47
42%
-68
- C2 -
-
5VI9
1
KAPCA_BOVIN
A:
[34-351]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
-
A
H
-
L
------
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
----
N
F
D
---
D
Y
E
-----------------------------------------------
526
Blastp_CBE
56.33
37%
-26
- C2 -
-
6BDL
1
KGP1_HUMAN
B:
[32-339]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
L
S
D
F
N
I
I
D
T
L
G
V
G
-
G
F
G
R
V
E
L
V
Q
L
K
S
---
E
---
E
---
S
K
T
F
A
M
K
I
L
K
K
R
H
I
V
D
-
T
-
R
Q
Q
E
H
I
R
S
E
K
Q
I
M
---
Q
-
G
A
H
S
D
F
I
V
R
L
Y
R
T
F
K
D
S
K
Y
L
Y
M
L
M
E
A
C
L
G
G
E
L
W
T
I
L
R
D
--
R
G
S
F
E
D
S
T
T
R
F
Y
T
A
C
V
V
E
A
F
A
Y
L
H
S
-
K
G
I
I
Y
R
D
L
K
P
E
N
L
I
L
D
H
R
-
G
Y
A
K
L
V
D
F
G
F
A
-
K
--
K
--
I
G
F
G
-
K
K
T
---
W
F
-
C
G
T
P
E
Y
V
A
P
E
I
I
L
N
K
-----
G
---
H
D
I
S
A
D
Y
W
S
L
G
I
L
M
Y
E
L
L
T
G
S
-
P
P
F
S
----
G
P
D
P
----
M
K
----
T
Y
N
I
I
-
L
R
GI
D
M
I
----
E
F
--
P
-----
K
K
I
A
K
N
A
A
N
L
I
K
K
L
C
R
D
N
P
S
E
--
R
L
-
G
N
L
--
K
--
N
-
G
V
K
D
--
I
Q
K
H
K
W
F
E
G
F
N
---
W
E
G
L
R
K
G
T
L
T
P
P
I
I
P
S
V
A
S
P
T
D
T
S
N
F
D
SF
P
E
D
N
-
D
E
-
P
P
P
D
D
--------------------------------------
97
Blastp_CBE
55.80
48%
-2
- C2 -
-
5D9K
2
KS6A3_HUMAN
B:
[27-323]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
-
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
K
I
S
GSD
A
---
R
---
Q
-
L
Y
A
M
K
V
L
-
K
K
A
T
L
K
-
V
-
R
D
R
V
R
T
K
M
E
R
D
I
L
--
V
E
--
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
-
G
H
I
K
L
T
D
F
G
L
S
-
K
--
E
----------------
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
-----
G
---
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
Q
----
G
K
D
R
----
K
E
----
T
M
T
M
I
-
L
K
--
A
K
L
----
G
M
--
P
-----
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
-
G
-
A
--
G
P-
D
-
G
V
E
E
--
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------
T
F
Y
F
D
--
P
--------------------------------------------------
528
Blastp_CBE
55.63
40%
-55
- C2 -
-
2BIY
8
PDPK1_HUMAN
A:
[31-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
VL
S
-
P
E
S
K
Q
-
A
R
A
N
--
A
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
Y
L
----
I
F
Q
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
511
Blastp_CBE
55.52
40%
-72
- C2 -
-
2R7B
2
PDPK1_HUMAN
A:
[34-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
VL---------------
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
Y
L
----
I
F
Q
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
521
Blastp_CBE
55.33
37%
-22
- C2 -
-
6C0T
3
KGP1_HUMAN
A:
[32-339]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
L
S
D
F
N
I
I
D
T
L
G
V
G
-
G
F
G
R
V
E
L
V
Q
L
K
S
---
E
---
E
---
S
K
T
F
A
M
K
I
L
K
K
R
H
I
V
D
-
T
-
R
Q
Q
E
H
I
R
S
E
K
Q
I
M
---
Q
-
G
A
H
S
D
F
I
V
R
L
Y
R
T
F
K
D
S
K
Y
L
Y
M
L
M
E
A
C
L
G
G
E
L
W
T
I
L
R
D
--
R
G
S
F
E
D
S
T
T
R
F
Y
T
A
C
V
V
E
A
F
A
Y
L
H
S
-
K
G
I
I
Y
R
D
L
K
P
E
N
L
I
L
D
H
R
-
G
Y
A
K
L
V
D
F
G
F
A
-
K
--
K
--
I
G
F
G
-
K
K
T
---
W
F
-
C
G
T
P
E
Y
V
A
P
E
I
I
L
N
K
-----
G
---
H
D
I
S
A
D
Y
W
S
L
G
I
L
M
Y
E
L
L
T
G
S
-
P
P
F
S
----
G
P
D
P
----
M
K
----
T
Y
N
I
I
-
L
R
GI
D
M
I
----
E
F
--
P
-----
K
K
I
A
K
N
A
A
N
L
I
K
K
L
C
R
D
N
P
S
E
--
R
L
-
G
N
L
--
K
--
N
-
G
V
K
D
--
I
Q
K
H
K
W
F
E
G
F
N
---
W
E
G
L
R
K
G
T
L
T
P
P
I
I
P
S
V
A
S
P
T
D
T
S
N
F
D
SF
P
E
D
N
-
D
E
-
P
P
P
D
D
--------------------------------------
532
Blastp_CBE
55.23
40%
-63
- C2 -
-
3PWY
1
PDPK1_HUMAN
A:
[33-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
C
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
VL
S
-
P
-----------
S
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
S
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
Y
L
----
I
F
Q
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
534
Blastp_CBE
55.11
38%
-100
- C2 -
-
5LOH
3
GWL_HUMAN
B:
[37-316]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
S
I
V
K
P
I
S
R
G
-
A
F
G
K
V
Y
L
G
Q
K
G
G
---
K
---------
L
Y
A
V
K
V
V
K
K
A
D
M
I
N
-
K
----------------
A
L
-
S
-
K
S
P
F
I
V
H
L
Y
Y
S
L
Q
S
A
N
N
V
Y
L
V
M
E
Y
L
I
G
G
D
V
K
S
L
L
H
I
--
Y
G
Y
F
D
E
E
M
A
V
K
Y
I
S
E
V
A
L
A
L
D
Y
L
H
R
-
H
G
I
I
H
R
D
L
K
P
D
N
M
L
I
S
N
E
-
G
H
I
K
L
T
D
F
G
L
-----------------------
G
T
P
D
Y
L
A
P
E
L
L
L
G
R
-----
A
---
H
G
P
A
V
D
W
W
A
L
G
V
C
L
F
E
F
L
T
G
I
-
P
P
F
N
----
D
E
T
P
----
Q
Q
----
V
F
Q
N
I
-
L
K
--
R
D
I
PWP-
E
G
--
E
-----
E
K
L
S
D
N
A
Q
S
A
V
E
I
L
L
T
I
D
D
T
K
--
R
A
-
G
-
M
--
K
-------
E
--
L
K
R
H
P
L
F
S
D
V
D
---
W
E
N
L
Q
H
Q
--
T
M
P
F
I
P
Q
P
---------------------------------------------------------------
438
Blastp_CBE
55.07
42%
-40
- C2 -
-
4OTI
1
A:
[13-310]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
L
A
V
L
G
R
G
-
H
F
G
K
V
L
L
S
E
F
R
P
---
S
---
G
---
E
-
L
F
A
I
K
A
L
K
K
G
D
I
V
A
-
R
-
D
E
V
E
S
L
M
C
E
K
R
I
L
AA
V
T
-
S
A
G
H
P
F
L
V
N
L
F
G
C
F
Q
T
P
E
H
V
C
F
V
M
E
Y
S
A
G
G
D
L
M
L
H
I
H
S
--
D
-
V
F
S
E
P
R
A
I
F
Y
S
A
C
V
V
L
G
L
Q
F
L
H
E
-
H
K
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
T
E
-
G
Y
V
K
I
A
D
F
G
L
-----------------------------------------------
T
R
A
V
D
W
W
G
L
G
V
L
L
Y
E
M
L
V
G
E
-
S
P
F
P
----
G
D
D
E
----
E
E
----
V
F
D
S
I
-
V
N
--
D
E
V
----
R
Y
--
P
-----
R
F
L
S
A
E
A
I
G
I
M
R
R
L
L
R
R
N
P
E
R
--
R
L
-
G
-
S
--
S
--
E
R
D
A
E
D
--
V
K
K
Q
P
F
F
R
T
L
G
---
W
E
A
L
L
A
R
R
L
P
P
P
F
V
P
T
L
S
G
R
T
D
V
S
N
F
D
--
E
E
F
T
-
G
E
--------------------------------------------
494
Blastp_CBE
54.94
41%
-95
- C2 -
-
3QC4
1
PDPK1_HUMAN
B:
[36-311]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
----------
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
P
E
S
---------
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
Y
L
----
I
F
Q
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
A
A
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
515
Blastp_CBE
54.69
38%
-35
- C2 -
-
4UAL
2
MRCKB_HUMAN
A:
[77-384]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
E
I
I
K
V
I
G
R
G
-
A
F
G
E
V
A
V
V
K
M
K
N
---
T
---
E
---
R
-
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
-
R
-
A
E
T
A
C
F
R
E
E
R
D
V
L
--
V
--
N
G
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F-
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
-
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
-
G
H
I
R
L
A
D
F
G
S
C
L
K
--
M
-
N
D
D
G
T
-
V
-----
V
A
-
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
-----
E
DGK
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
-
T
P
F
Y
----
A
E
S
L
----
V
E
----
T
Y
G
K
I
-
M
N
--
H
E
E
----
R
F
--
Q
FPSHV
T
D
V
S
E
E
A
K
D
L
I
Q
R
L
I
C
S
-
R
E
R
--
R
L
-
G
----
Q
--
N
-
G
I
E
D
--
F
K
K
H
A
F
F
E
G
L
N
---
W
E
N
I
R
N
--
L
E
A
P
Y
I
P
D
V
S
S
P
S
D
T
S
N
F
D
-----------------------------------------------------
527
Blastp_CBE
54.55
37%
-26
- C2 -
-
6BDL
1
KGP1_HUMAN
A:
[32-339]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
L
S
D
F
N
I
I
D
T
L
G
V
G
-
G
F
G
R
V
E
L
V
Q
L
K
S
---
E
---
E
---
S
K
T
F
A
M
K
I
L
K
K
R
H
I
V
D
-
T
-
R
Q
Q
E
H
I
R
S
E
K
Q
I
M
---
Q
-
G
A
H
S
D
F
I
V
R
L
Y
R
T
F
K
D
S
K
Y
L
Y
M
L
M
E
A
C
L
G
G
E
L
W
T
I
L
R
D
--
R
G
S
F
E
D
S
T
T
R
F
Y
T
A
C
V
V
E
A
F
A
Y
L
H
S
-
K
G
I
I
Y
R
D
L
K
P
E
N
L
I
L
D
H
R
-
G
Y
A
K
L
V
D
F
G
F
A
-
K
--
K
--
I
G
F
G
-
K
K
T
---
W
F
-
C
G
T
P
E
Y
V
A
P
E
I
I
L
N
K
-----
G
---
H
D
I
S
A
D
Y
W
S
L
G
I
L
M
Y
E
L
L
T
G
S
-
P
P
F
S
----
G
P
D
P
----
M
K
----
T
Y
N
I
I
-
L
R
GI
D
M
I
----
E
F
--
P
-----
K
K
I
A
K
N
A
A
N
L
I
K
K
L
C
R
D
N
P
S
E
--
R
L
-
G
N
L
--
K
--
N
-
G
V
K
D
--
I
Q
K
H
K
W
F
E
G
F
N
---
W
E
G
L
R
K
G
T
L
T
P
P
I
I
P
S
V
A
S
P
T
D
T
S
N
F
D
SF
P
E
D
N
-
D
E
-
P
P
P
D
D
--------------------------------------
492
Blastp_CBE
54.53
41%
-118
- C2 -
-
5HKM
1
PDPK1_HUMAN
A:
[31-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
------------
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
Y
L
----
I
F
Q
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
495
Blastp_CBE
54.38
41%
-89
- C2 -
-
3QC4
1
PDPK1_HUMAN
A:
[36-311]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
P
E
S
---------
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
Y
L
----
I
F
Q
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
A
A
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
174
Blastp_CBE
54.21
39%
-13
- C2 -
-
5M0B
4
KAPCA_CRIGR
A:
[4-338]
------------------------------------------------------------------------------------------------------------
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
510
Blastp_CBE
53.93
40%
-65
- C2 -
-
3ION
1
PDPK1_HUMAN
A:
[34-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
VL
S
----------------
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
Y
L
----
I
F
Q
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
491
Blastp_CBE
53.89
41%
-115
- C2 -
-
5HNG
1
PDPK1_HUMAN
A:
[31-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
P
----------
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
Y
L
----
I
F
Q
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
531
Blastp_CBE
53.84
40%
-62
- C2 -
-
3NAX
1
PDPK1_HUMAN
A:
[30-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
VL
S
-
P
E
S
K
Q
-
A
R
----------
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
Y
L
----
I
F
Q
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
489
Blastp_CBE
53.81
41%
-111
- C2 -
-
5HO8
1
PDPK1_HUMAN
A:
[31-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
-----------
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
Y
L
----
I
F
Q
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
451
Blastp_CBE
53.67
41%
-115
- C2 -
-
5LVP
1
PDPK1_HUMAN
D:
[33-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
------------
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
G
L
----
I
F
A
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
490
Blastp_CBE
53.35
41%
-113
- C2 -
-
5HO7
1
PDPK1_HUMAN
A:
[31-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
P
----------
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
Y
L
----
I
F
Q
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
178
Blastp_CBE
53.07
39%
-12
- C2 -
-
5LCQ
3
KAPCA_CRIGR
A:
[4-338]
------------------------------------------------------------------------------------------------------------
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
167
Blastp_CBE
53.02
39%
-10
- C2 -
-
5M75
2
KAPCA_CRIGR
A:
[4-338]
------------------------------------------------------------------------------------------------------------
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
114
Blastp_CBE
52.92
48%
-12
- C2 -
-
4GUE
1
KS6A3_MOUSE
A:
[22-305]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
-
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
K
I
S
GSD
A
---
R
---
Q
-
L
Y
A
M
K
V
L
-
K
K
A
T
L
K
-
V
-
R
D
R
V
--------
L
--
V
E
--
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
-
G
H
I
K
L
T
D
F
G
L
S
-
K
--------
E
-
K
K
A
Y
--
S
F
-
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
-----
G
---
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
Q
----
G
K
D
R
----
K
E
----
T
M
T
M
I
-
L
K
--
A
K
L
----
G
M
--
P
-----
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
-
G
-
A
--
G
P-
D
-
G
V
E
E
--
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-----------------------------------------------------------------
62
Blastp_CBE
52.91
47%
-16
- C2 -
-
3A62
1
KS6B1_HUMAN
A:
[13-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
I
R
-
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
---
G
---
A
NTG
K
-
I
F
A
M
K
V
L
K
---------------
K
A
E
R
N
I
L
---
E
-
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
L
C
-
K
--
E
--------------
F
-
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
-----
G
---
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
T
----
G
E
N
R
----
K
K
----
T
I
D
K
I
-
L
K
--
C
K
L
----
N
L
--
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
-
G
-
A
--
G
P-
G
-
D
A
G
E
--
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
----------------------------------------------------------------
454
Blastp_CBE
52.83
41%
-116
- C2 -
-
5LVP
1
PDPK1_HUMAN
A:
[33-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
------------
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
G
L
----
I
F
A
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
116
Blastp_CBE
52.82
48%
-14
- C2 -
-
3UBD
1
KS6A3_MOUSE
A:
[21-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
-
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
K
I
S
GSD
A
---
R
---
Q
-
L
Y
A
M
K
V
L
-
K
K
A
T
L
K
-
V
-
R
D
R
V
------
D
I
L
--
V
E
--
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
-
G
H
I
K
L
T
D
F
G
L
S
-
K
--------
E
-
K
K
A
Y
--
S
F
-
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
-----
G
---
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
Q
----
G
K
D
R
----
K
E
----
T
M
T
M
I
-
L
K
--
A
K
L
----
G
M
--
P
-----
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
-
G
-
A
--
G
P-
D
-
G
V
E
E
--
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-----------------------------------------------------------------
535
Blastp_CBE
52.80
38%
-104
- C2 -
-
5LOH
2
GWL_HUMAN
A:
[37-316]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
S
I
V
K
P
I
S
-----
G
K
V
Y
L
G
Q
K
G
G
---
K
---------
L
Y
A
V
K
V
V
K
K
A
D
M
-----------------
L
--
A
L
-
S
-
K
S
P
F
I
V
H
L
Y
Y
S
L
Q
S
A
N
N
V
Y
L
V
M
E
Y
L
I
G
G
D
V
K
S
L
L
H
I
--
Y
G
Y
F
D
E
E
M
A
V
K
Y
I
S
E
V
A
L
A
L
D
Y
L
H
R
-
H
G
I
I
H
R
D
L
K
P
D
N
M
L
I
S
N
E
-
G
H
I
K
L
T
D
F
G
L
S
-
K
-----------------
F
-
C
G
T
P
D
Y
L
A
P
E
L
L
L
G
R
-----
A
---
H
G
P
A
V
D
W
W
A
L
G
V
C
L
F
E
F
L
T
G
I
-
P
P
F
N
----
D
E
T
P
----
Q
Q
----
V
F
Q
N
I
-
L
K
--
R
D
I
PWP-
E
G
--
E
-----
E
K
L
S
D
N
A
Q
S
A
V
E
I
L
L
T
I
D
D
T
K
--
R
A
-
G
-
M
--
K
-------
E
--
L
K
R
H
P
L
F
S
D
V
D
---
W
E
N
L
Q
H
Q
--
T
M
P
F
I
P
Q
P
---------------------------------------------------------------
179
Blastp_CBE
52.77
39%
-10
- C2 -
-
5LCP
5
KAPCA_CRIGR
A:
[4-338]
------------------------------------------------------------------------------------------------------------
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
177
Blastp_CBE
52.77
39%
-11
- C2 -
-
5LCR
6
KAPCA_CRIGR
A:
[4-338]
------------------------------------------------------------------------------------------------------------
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
231
Blastp_CBE
52.76
46%
-1
- C2 -
-
6G77
2
KS6A6_HUMAN
A:
[26-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
-
P
A
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
K
T
GPD
A
---
G
---
Q
-
L
Y
A
M
K
V
L
-
K
K
A
S
L
K
-
V
-
R
D
--------
D
I
L
--
V
E
--
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
--
E
V
L
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
E
I
-
G
H
I
K
L
T
D
F
G
L
S
-
K
--
E
-
S
V
D
Q
E
-
K
K
A
Y
--
S
F
-
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
-----
G
---
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
Q
----
G
K
D
R
----
N
E
----
T
M
N
M
I
-
L
K
--
A
K
L
----
G
M
--
P
-----
Q
F
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
-
G
-
S
-----
E
-
G
V
E
E
--
I
K
R
H
L
F
F
A
N
I
D
---
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
-----------------------------------------------------------------
283
Blastp_CBE
52.67
39%
1
- C2 -
-
6EH3
1
KAPCA_CRIGR
A:
[4-338]
------------------------------------------------------------------------------------------------------------
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
-
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
453
Blastp_CBE
52.66
41%
-105
- C2 -
-
5LVP
1
PDPK1_HUMAN
B:
[33-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
-----------
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
G
L
----
I
F
A
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
169
Blastp_CBE
52.61
39%
-10
- C2 -
-
5M6Y
2
KAPCA_CRIGR
A:
[4-338]
------------------------------------------------------------------------------------------------------------
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
96
Blastp_CBE
52.56
48%
-9
- C2 -
-
3G51
1
KS6A3_MOUSE
A:
[21-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
-
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
K
I
S
GSD
A
---
R
---
Q
-
L
Y
A
M
K
V
L
-
K
K
A
T
L
K
-
V
----------
R
D
I
L
--
V
E
--
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
-
G
H
I
K
L
T
D
F
G
L
S
-
K
--
E
-
S
I
---------------
T
V
E
Y
M
A
P
E
V
V
N
R
R
-----
G
---
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
Q
----
G
K
D
R
----
K
E
----
T
M
T
M
I
-
L
K
--
A
K
L
----
G
M
--
P
-----
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
-
G
-
A
--
G
P-
D
-
G
V
E
E
--
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-----------------------------------------------------------------
463
Blastp_CBE
52.45
41%
-95
- C2 -
-
4AW1
4
PDPK1_HUMAN
A:
[33-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
P
E
S
--------
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
G
L
----
I
F
A
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
160
Blastp_CBE
52.39
39%
-11
- C2 -
-
5N7U
2
KAPCA_CRIGR
A:
[4-338]
------------------------------------------------------------------------------------------------------------
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
161
Blastp_CBE
52.26
39%
-14
- C2 -
-
5N7P
2
KAPCA_CRIGR
A:
[4-338]
------------------------------------------------------------------------------------------------------------
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
289
Blastp_CBE
52.22
39%
-1
- C2 -
-
5OTG
1
KAPCA_CRIGR
A:
[4-338]
------------------------------------------------------------------------------------------------------------
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
-
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
166
Blastp_CBE
52.19
39%
-14
- C2 -
-
5MHI
4
KAPCA_CRIGR
A:
[4-338]
------------------------------------------------------------------------------------------------------------
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
--
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
268
Blastp_CBE
52.11
39%
3
- C2 -
-
6I2H
1
?
A:
[4-338]
------------------------------------------------------------------------------------------------------------
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
-
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
164
Blastp_CBE
52.10
39%
-12
- C2 -
-
5N1E
4
KAPCA_CRIGR
A:
[4-338]
------------------------------------------------------------------------------------------------------------
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
---
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
294
Blastp_CBE
52.05
39%
-0
- C2 -
-
5O0E
2
KAPCA_CRIGR
A:
[4-338]
------------------------------------------------------------------------------------------------------------
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
-
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
230
Blastp_CBE
52.04
46%
6
- C2 -
-
6G77
2
KS6A6_HUMAN
B:
[26-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
-
P
A
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
K
T
GPD
A
---
G
---
Q
-
L
Y
A
M
K
V
L
-
K
K
A
S
L
K
-
V
-
R
D
--------
D
I
L
--
V
E
--
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
--
E
V
L
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
E
I
-
G
H
I
K
L
T
D
F
G
L
S
-
K
--
E
-
S
V
D
Q
E
-
K
K
A
Y
--
S
F
-
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
-----
G
---
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
Q
----
G
K
D
R
----
N
E
----
T
M
N
M
I
-
L
K
--
A
K
L
----
G
M
--
P
-----
Q
F
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
-
G
-
S
-----
E
-
G
V
E
E
--
I
K
R
H
L
F
F
A
N
I
D
---
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
-----------------------------------------------------------------
295
Blastp_CBE
51.88
39%
-2
- C2 -
-
5NTJ
2
KAPCA_CRIGR
A:
[4-338]
------------------------------------------------------------------------------------------------------------
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
-
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
------
E
-
E
E
-
E
I
-----------------------------------------
317
Blastp_CBE
51.87
39%
-2
- C2 -
-
5N36
2
KAPCA_CRIGR
A:
[4-338]
------------------------------------------------------------------------------------------------------------
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
--
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
-
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
165
Blastp_CBE
51.86
39%
-14
- C2 -
-
5N1D
3
KAPCA_CRIGR
A:
[4-338]
------------------------------------------------------------------------------------------------------------
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
--
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
115
Blastp_CBE
51.79
48%
-8
- C2 -
-
4EL9
1
KS6A3_MOUSE
A:
[22-305]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
-
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
K
I
S
GSD
A
---
R
---
Q
-
L
Y
A
M
K
V
L
-
K
K
A
T
L
K
-
V
-
R
D
R
V
-----
R
D
I
L
--
V
E
--
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
-
G
H
I
K
L
T
D
F
G
L
S
-
K
--
E
-
S
---
E
-
K
K
A
Y
--
S
F
-
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
-----
G
---
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
Q
----
G
K
D
R
----
K
E
----
T
M
T
M
I
-
L
K
--
A
K
L
----
G
M
--
P
-----
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
-
G
-
A
--
G
P-
D
-
G
V
E
E
--
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-----------------------------------------------------------------
170
Blastp_CBE
51.77
39%
-10
- C2 -
-
5M6V
1
KAPCA_CRIGR
A:
[4-338]
------------------------------------------------------------------------------------------------------------
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
168
Blastp_CBE
51.71
39%
-9
- C2 -
-
5M71
2
KAPCA_CRIGR
A:
[4-338]
------------------------------------------------------------------------------------------------------------
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
176
Blastp_CBE
51.68
39%
-8
- C2 -
-
5LCT
4
KAPCA_CRIGR
A:
[4-338]
------------------------------------------------------------------------------------------------------------
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
314
Blastp_CBE
51.67
39%
-3
- C2 -
-
5N3A
4
KAPCA_CRIGR
A:
[4-338]
------------------------------------------------------------------------------------------------------------
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
-
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
292
Blastp_CBE
51.64
39%
-2
- C2 -
-
5OK3
1
KAPCA_CRIGR
A:
[4-338]
------------------------------------------------------------------------------------------------------------
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
-
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
322
Blastp_CBE
51.49
39%
-4
- C2 -
-
5N1L
4
KAPCA_CRIGR
A:
[4-338]
------------------------------------------------------------------------------------------------------------
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
--
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
-
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
315
Blastp_CBE
51.40
39%
-2
- C2 -
-
5N39
5
KAPCA_CRIGR
A:
[4-338]
------------------------------------------------------------------------------------------------------------
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
--
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
-
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
330
Blastp_CBE
51.42
46%
-4
- C2 -
-
6G78
1
KS6A6_HUMAN
A:
[26-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
-
P
A
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
K
T
GPD
A
---
G
---
Q
-
L
Y
A
M
K
V
L
-
K
K
A
S
L
K
-
V
-
R
D
--------
D
I
L
--
V
E
--
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
--
E
V
L
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
E
I
-
G
H
I
K
L
T
D
F
G
L
S
-
K
--
E
-
S
V
D
Q
------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
-----
G
---
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
Q
----
G
K
D
R
----
N
E
----
T
M
N
M
I
-
L
K
--
A
K
L
----
G
M
--
P
-----
Q
F
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
-
G
-
S
-----
E
-
G
V
E
E
--
I
K
R
H
L
F
F
A
N
I
D
---
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
-----------------------------------------------------------------
175
Blastp_CBE
51.40
39%
-10
- C2 -
-
5LCU
5
KAPCA_CRIGR
A:
[4-338]
------------------------------------------------------------------------------------------------------------
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
287
Blastp_CBE
51.35
39%
1
- C2 -
-
5OUC
2
KAPCA_CRIGR
A:
[4-338]
------------------------------------------------------------------------------------------------------------
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
-
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
272
Blastp_CBE
51.33
39%
-0
- C2 -
-
6I2A
1
KAPCA_CRIGR
A:
[4-338]
------------------------------------------------------------------------------------------------------------
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
-
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
310
Blastp_CBE
51.19
39%
-3
- C2 -
-
5N3E
3
KAPCA_CRIGR
A:
[4-338]
------------------------------------------------------------------------------------------------------------
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
-
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
-
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
312
Blastp_CBE
51.15
39%
-3
- C2 -
-
5N3C
2
KAPCA_CRIGR
A:
[4-338]
------------------------------------------------------------------------------------------------------------
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
-
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
-
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
279
Blastp_CBE
50.81
39%
0
- C2 -
-
6EMB
1
KAPCA_CRIGR
A:
[4-338]
------------------------------------------------------------------------------------------------------------
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
-
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
171
Blastp_CBE
50.81
39%
-15
- C2 -
-
5M0U
10
KAPCA_CRIGR
A:
[4-338]
------------------------------------------------------------------------------------------------------------
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
-----
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
321
Blastp_CBE
50.80
39%
-4
- C2 -
-
5N1M
3
KAPCA_CRIGR
A:
[4-338]
------------------------------------------------------------------------------------------------------------
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
--
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
-
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
318
Blastp_CBE
50.79
39%
0
- C2 -
-
5N33
3
KAPCA_CRIGR
A:
[4-338]
------------------------------------------------------------------------------------------------------------
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
--
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
-
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
437
Blastp_CBE
50.61
44%
-31
- C2 -
-
4CRS
1
A:
[13-317]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
R
C
C
A
V
L
L
R
G
-
H
F
G
K
V
L
L
A
E
Y
K
N
---
T
---
N
---
E
-
M
F
A
I
K
A
L
K
K
G
D
I
V
A
-
R
-
D
E
V
D
S
L
M
C
E
K
R
I
F
ET
V
N
-
S
V
R
H
P
F
L
V
N
L
F
A
C
F
Q
T
K
E
H
V
C
F
V
M
E
Y
A
A
G
G
D
L
M
M
H
I
H
T
--
D
--
V
F
E
P
R
A
V
F
Y
A
A
C
V
V
L
G
L
Q
Y
L
H
E
-
H
K
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
T
E
-
G
F
V
K
I
A
D
F
G
L
C
-
K
--
E
-
G
M
G
Y
G
-
D
R
T
S
---
F
-
C
G
T
P
E
F
L
A
P
E
V
L
T
E
T
-----
S
---
Y
T
R
A
V
D
W
W
G
L
G
V
L
I
Y
E
M
L
V
G
E
-
S
P
F
P
----
G
D
D
E
----
E
E
----
V
F
D
S
I
-
V
N
--
D
E
V
----
R
Y
--
P
-----
R
F
L
S
T
E
A
I
S
I
M
R
R
L
L
R
R
N
P
E
R
--
R
L
-
G
-
A
--
S
--
E
K
D
A
E
D
--
V
K
K
H
P
F
F
R
L
I
D
---
W
S
A
L
M
D
K
K
V
K
P
P
F
I
P
T
I
R
G
R
E
D
V
S
N
F
D
--
D
E
F
T
-
S
E
--------------------------------------------
529
Blastp_CBE
50.60
41%
-67
- C2 -
-
4AW0
4
PDPK1_HUMAN
A:
[33-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
P
E
S
K
-
Q
A
R
A
--
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
----
A
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
G
L
----
I
F
A
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
105
Blastp_CBE
50.48
47%
-10
- C2 -
-
2Z7S
1
KS6A1_HUMAN
A:
[24-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
D
-
P
S
H
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
V
T
---
R
PDS
G
---
H
-
L
Y
A
M
K
V
L
-
K
-------------------
I
L
---
A
-
D
V
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
-
G
H
I
K
L
T
D
F
G
L
S
-
K
--
E
-----------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
Q
-----
G
---
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
-
L
P
F
Q
----
G
K
D
R
----
K
E
----
T
M
T
L
I
-
L
K
--
A
K
L
----
G
M
--
P
-----
Q
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
--
R
L
-
G
-
S
--
G
P-
D
-
G
A
E
E
--
I
K
R
H
V
F
Y
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
-----------------------------------------------------------------
482
Blastp_CBE
50.46
41%
-61
- C2 -
-
4XX9
6
PDPK1_HUMAN
A:
[32-307]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
P
E
S
K
-
Q
A
R
A
--
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
G
L
----
I
F
A
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
458
Blastp_CBE
50.36
41%
-60
- C2 -
-
5LVL
5
PDPK1_HUMAN
A:
[33-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
P
E
S
K
-
Q
A
R
A
--
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
G
L
----
I
F
A
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
106
Blastp_CBE
50.25
47%
3
- C2 -
-
2Z7R
1
KS6A1_HUMAN
A:
[21-308]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
E
K
A
D
-
P
S
H
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
V
T
---
R
PDS
G
---
H
-
L
Y
A
M
K
V
L
-
K
K
A
T
L
K
-
V
------------
I
L
---
A
-
D
V
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
-
G
H
I
K
L
T
D
F
G
L
S
-
K
--
E
-----------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
Q
-----
G
---
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
-
L
P
F
Q
----
G
K
D
R
----
K
E
----
T
M
T
L
I
-
L
K
--
A
K
L
----
G
M
--
P
-----
Q
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
--
R
L
-
G
-
S
--
G
P-
D
-
G
A
E
E
--
I
K
R
H
V
F
Y
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
-----------------------------------------------------------------
67
Blastp_CBE
50.24
47%
-18
- C2 -
-
3WF5
1
KS6B1_HUMAN
A:
[15-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
I
R
-
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
---
G
---
A
NTG
K
-
I
F
A
M
K
V
L
K
K
-------------
T
K
A
E
R
N
I
L
---
E
-
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
L
C
-
K
--
E
-
S
I
-
H
D
-
G
T
V
T
--
H
F
-
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
-----
G
---
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
T
----
G
E
N
R
----
K
K
----
T
I
D
K
I
-
L
K
--
C
K
L
----
N
L
--
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
-
G
-
A
--
G
P-
G
-
D
A
G
E
--
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
-------------------------------------------------------------
530
Blastp_CBE
50.21
41%
-63
- C2 -
-
4A07
3
PDPK1_HUMAN
A:
[33-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
P
E
S
K
-
Q
A
R
A
--
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
----
A
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
G
L
----
I
F
A
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
457
Blastp_CBE
50.07
41%
-62
- C2 -
-
5LVM
2
PDPK1_HUMAN
A:
[33-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
P
E
S
K
-
Q
A
R
A
--
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
G
L
----
I
F
A
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
441
Blastp_CBE
50.01
39%
-53
- C2 -
-
1UVR
8
PDPK1_HUMAN
A:
[1-286]
--------------------------------------------------------------------------------------------------------------------------------------------
P
P
Q
P
R
K
K
---------------
R
-
P
E
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
P
-----
A
R
A
--
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
Y
L
----
I
F
Q
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
320
Blastp_CBE
49.97
39%
-3
- C2 -
-
5N1N
2
KAPCA_CRIGR
A:
[4-338]
------------------------------------------------------------------------------------------------------------
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
-
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
-
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
466
Blastp_CBE
49.89
41%
-60
- C2 -
-
3HRF
4
PDPK1_HUMAN
A:
[33-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
P
E
S
K
-
Q
A
R
A
--
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
G
L
----
I
F
A
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
462
Blastp_CBE
49.81
41%
-58
- C2 -
-
4RQK
5
PDPK1_HUMAN
A:
[33-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
P
E
S
K
-
Q
A
R
A
--
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
G
L
----
I
F
A
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
63
Blastp_CBE
49.78
47%
5
- C2 -
-
3WF9
2
KS6B1_HUMAN
A:
[15-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
I
R
-
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
---
G
---
A
NTG
K
-
I
F
A
M
K
V
L
K
K
A
M
I
V
R
-
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
---
E
-
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
L
C
-
K
--
E
-
S
I
-
H
D
-
G
T
V
T
--
H
F
-
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
-----
G
---
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
T
----
G
E
N
R
----
K
K
----
T
I
D
K
I
-
L
K
--
C
K
L
----
N
L
--
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
-
G
-
A
--
G
P-
G
-
D
A
G
E
--
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
---------------------------------------------------------------
455
Blastp_CBE
49.77
41%
-64
- C2 -
-
5LVO
4
PDPK1_HUMAN
A:
[33-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
P
E
S
K
-
Q
A
R
A
--
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
G
L
----
I
F
A
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
329
Blastp_CBE
49.55
46%
-6
- C2 -
-
6G78
1
KS6A6_HUMAN
B:
[26-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
-
P
A
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
K
T
GPD
A
---
G
---
Q
-
L
Y
A
M
K
V
L
-
K
K
A
S
L
K
-
V
-
R
D
--------
D
I
L
--
V
E
--
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
--
E
V
L
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
E
I
-
G
H
I
K
L
T
D
F
G
L
S
-
K
--
E
-
S
V
--------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
-----
G
---
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
Q
----
G
K
D
R
----
N
E
----
T
M
N
M
I
-
L
K
--
A
K
L
----
G
M
--
P
-----
Q
F
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
-
G
-
S
-----
E
-
G
V
E
E
--
I
K
R
H
L
F
F
A
N
I
D
---
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
-----------------------------------------------------------------
481
Blastp_CBE
49.50
38%
-59
- C2 -
-
5MRD
5
PDPK1_HUMAN
A:
[27-307]
-------------------------------------------------------------------------------------------------------------------------------------------------
S
K
---------------
R
-
P
E
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
V
E
K
R
H
V
N
K
-
E
-
N
K
I
P
Y
V
Q
R
E
K
D
V
M
--
S
R
--
L
D
H
P
F
F
V
K
L
Y
F
C
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
P
E
S
K
-
Q
A
R
A
--
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
G
L
----
I
F
A
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
459
Blastp_CBE
49.45
41%
-60
- C2 -
-
5ACK
4
PDPK1_HUMAN
A:
[33-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
P
E
S
K
-
Q
A
R
A
--
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
G
L
----
I
F
A
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
537
Blastp_CBE
49.43
39%
-61
- C2 -
-
4CT1
4
PDPK1_HUMAN
A:
[33-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
V
E
K
R
H
V
H
K
-
E
-
N
K
I
P
Y
V
Q
R
E
K
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
C
F
Q
D
D
E
K
L
Y
L
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
P
E
S
K
-
Q
A
R
A
--
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
G
L
----
I
F
A
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
64
Blastp_CBE
49.39
47%
8
- C2 -
-
3WF8
2
KS6B1_HUMAN
A:
[15-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
I
R
-
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
---
G
---
A
NTG
K
-
I
F
A
M
K
V
L
K
K
A
M
I
V
R
-
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
---
E
-
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
L
C
-
K
--
E
-
S
I
-
H
D
-
G
T
V
T
--
H
F
-
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
-----
G
---
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
T
----
G
E
N
R
----
K
K
----
T
I
D
K
I
-
L
K
--
C
K
L
----
N
L
--
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
-
G
-
A
--
G
P-
G
-
D
A
G
E
--
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
---------------------------------------------------------------
61
Blastp_CBE
49.29
47%
-9
- C2 -
-
3A60
1
KS6B1_HUMAN
A:
[13-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
I
R
-
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
---
G
---
A
NTG
K
-
I
F
A
M
K
V
L
K
K
A
M
------------
K
A
E
R
N
I
L
---
E
-
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
L
C
-
K
--
E
------------------
T
I
E
Y
M
A
P
E
I
L
M
R
S
-----
G
---
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
T
----
G
E
N
R
----
K
K
----
T
I
D
K
I
-
L
K
--
C
K
L
----
N
L
--
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
-
G
-
A
--
G
P-
G
-
D
A
G
E
--
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----------------------------------------------------------------
460
Blastp_CBE
49.19
41%
-59
- C2 -
-
4RRV
3
PDPK1_HUMAN
A:
[33-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
P
E
S
K
-
Q
A
R
A
--
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
G
L
----
I
F
A
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
393
Blastp_CBE
49.22
46%
-25
- C2 -
-
6G76
2
KS6A6_HUMAN
A:
[26-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
-
P
A
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
K
T
GPD
A
---
G
---
Q
-
L
Y
A
M
K
V
L
-
K
K
A
S
L
K
-
V
-
R
D
--------
D
I
L
--
V
E
--
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
--
E
V
L
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
E
I
-
G
H
I
K
L
T
D
F
G
L
S
-
K
--
E
-
S
V
D
Q
E
-
K
-
K
A
--
Y
F
-
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
-----
G
---
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
Q
----
G
K
D
R
----
N
E
----
T
M
N
M
I
-
L
K
--
A
K
L
----
G
M
--
P
-----
Q
F
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
-
G
-
S
-----
E
-
G
V
E
E
--
I
K
R
H
L
F
F
A
N
I
D
---
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
-----------------------------------------------------------------
456
Blastp_CBE
49.19
41%
-61
- C2 -
-
5LVN
2
PDPK1_HUMAN
A:
[33-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
P
E
S
K
-
Q
A
R
A
--
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
G
L
----
I
F
A
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
107
Blastp_CBE
49.18
47%
-11
- C2 -
-
2Z7Q
1
KS6A1_HUMAN
A:
[24-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
D
-
P
S
H
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
V
T
---
R
PDS
G
---
H
-
L
Y
A
M
K
V
L
---------------------
I
L
---
A
-
D
V
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
-
G
H
I
K
L
T
D
F
G
L
S
-
K
--
E
-----------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
Q
-----
G
---
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
-
L
P
F
Q
----
G
K
D
R
----
K
E
----
T
M
T
L
I
-
L
K
--
A
K
L
----
G
M
--
P
-----
Q
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
--
R
L
-
G
-
S
--
G
P-
D
-
G
A
E
E
--
I
K
R
H
V
F
Y
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
-----------------------------------------------------------------
442
Blastp_CBE
49.12
39%
-49
- C2 -
-
1H1W
9
PDPK1_HUMAN
A:
[1-286]
--------------------------------------------------------------------------------------------------------------------------------------------
P
P
Q
P
R
K
K
---------------
R
-
P
E
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
P
-----
A
R
A
--
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
Y
L
----
I
F
Q
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
461
Blastp_CBE
49.06
41%
-57
- C2 -
-
4RQV
6
PDPK1_HUMAN
A:
[33-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
P
E
S
K
-
Q
A
R
A
--
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
G
L
----
I
F
A
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
464
Blastp_CBE
48.90
41%
-56
- C2 -
-
4A06
3
PDPK1_HUMAN
A:
[33-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
P
E
S
K
-
Q
A
R
A
--
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
G
L
----
I
F
A
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
465
Blastp_CBE
48.89
41%
-55
- C2 -
-
3RCJ
1
PDPK1_HUMAN
A:
[33-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
P
E
S
K
-
Q
A
R
A
--
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
G
L
----
I
F
A
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
66
Blastp_CBE
48.85
47%
-16
- C2 -
-
3WF6
1
KS6B1_HUMAN
A:
[15-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
I
R
-
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
---
G
---
A
NTG
K
-
I
F
A
M
K
V
L
K
K
-------------
T
K
A
E
R
N
I
L
---
E
-
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
L
C
-
K
--
E
-
S
I
-
H
D
-
G
T
V
T
--
H
F
-
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
-----
G
---
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
T
----
G
E
N
R
----
K
K
----
T
I
D
K
I
-
L
K
--
C
K
L
----
N
L
--
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
-
G
-
A
--
G
P-
G
-
D
A
G
E
--
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
-------------------------------------------------------------
536
Blastp_CBE
48.58
39%
-62
- C2 -
-
4CT2
2
PDPK1_HUMAN
A:
[33-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
V
E
K
R
H
--------
I
P
Y
V
Q
R
E
K
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
C
F
Q
D
D
E
K
L
Y
L
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
P
E
S
K
-
Q
A
R
A
--
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
G
L
----
I
F
A
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
390
Blastp_CBE
48.39
38%
-8
- C2 -
-
3AMB
1
KAPCA_HUMAN
A:
[4-336]
--------------------------------------------------------------------------------------------------------------
A
A
A
A
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
-----------------
A
H
-
L
D
Q
F
E
R
I
R
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
Q
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
K
V
A
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
-----
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
316
Blastp_CBE
48.39
39%
10
- C2 -
-
5N37
6
KAPCA_CRIGR
A:
[1-338]
------------------------------------------------------------------------------------------------------------
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
-
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
60
Blastp_CBE
48.37
47%
-7
- C2 -
-
3A60
1
KS6B1_HUMAN
B:
[13-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
I
R
-
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
---
G
---
A
NTG
K
-
I
F
A
M
K
V
L
K
K
----------------------------
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
L
C
-
K
--
E
-
S
--------------
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
-----
G
---
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
T
----
G
E
N
R
----
K
K
----
T
I
D
K
I
-
L
K
--
C
K
L
----
N
L
--
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
-
G
-
A
--
G
P-
G
-
D
A
G
E
--
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
----------------------------------------------------------------
391
Blastp_CBE
47.98
38%
-7
- C2 -
-
3AMA
1
KAPCA_HUMAN
A:
[2-336]
------------------------------------------------------------------------------------------------------------
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
-----------------
A
H
-
L
D
Q
F
E
R
I
R
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
Q
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
K
V
A
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
-----
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
506
Blastp_CBE
47.48
41%
-57
- C2 -
-
3RWQ
4
PDPK1_HUMAN
A:
[33-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
P
-----
A
R
A
--
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
Y
L
----
I
F
Q
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
274
Blastp_CBE
47.48
39%
2
- C2 -
-
6ERW
2
KAPCA_CRIGR
A:
[4-338]
------------------------------------------------------------------------------------------------------------
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
T
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
----
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
-
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
467
Blastp_CBE
47.46
41%
-60
- C2 -
-
3HRC
1
PDPK1_HUMAN
A:
[33-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
E
L
A
---
T
---
S
---
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
-
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
--
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
-
K
--
V
L
S
P
-----
A
R
A
--
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
---
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
----
A
G
N
E
----
G
L
----
I
F
A
K
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
59
Blastp_CBE
47.28
47%
-1
- C2 -
-
3A61
1
KS6B1_HUMAN
A:
[15-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
---
G
---
A
NTG
K
-
I
F
A
M
K
V
L
----------------
K
A
E
R
N
I
L
---
E
-
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
------------------------
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
-----
G
---
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
T
----
G
E
N
R
----
K
K
----
T
I
D
K
I
-
L
K
--
C
K
L
----
N
L
--
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
-
G
-
A
--
G
P-
G
-
D
A
G
E
--
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----------------------------------------------------------------
73
Blastp_CBE
47.06
50%
-2
- C2 -
-
4RLO
4
KS6B1_HUMAN
B:
[3-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
---
G
---
A
NTG
K
-
I
F
A
M
K
V
L
K
K
----------------------------
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
--
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
L
C
-
K
--
E
-
S
I
---------------
T
I
E
Y
M
A
P
E
I
L
M
R
S
-----
G
---
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
T
----
G
E
N
R
----
K
K
----
T
I
D
K
I
-
L
K
--
C
K
L
----
N
L
--
P
-----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
-
G
-
A
--
G
P-
G
-
D
A
G
E
--
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----------------------------------------------------------------
392
Blastp_CBE
46.43
46%
-17
- C2 -
-
6G76
1
KS6A6_HUMAN
B:
[26-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
-
P
A
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
K
T
GPD
A
---
G
---
Q
-
L
Y
A
M
K
V
L
-
K
K
A
S
L
K
-
V
----------
R
D
I
L
--
V
E
--
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
--
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
--
E
V
L
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
E
I
-
G
H
I
K
L
T
D
F
G
L
S
-
K
--
E
-
S
V
D
---------------
V
E
Y
M
A
P
E
V
V
N
R
R
-----
G
---
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
Q
----
G
K
D
R
----
N
E
----
T
-----------
L
----
G
M
--
P
-----
Q
F
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
-
G
-
S
-----
E
-
G
V
E
E
--
I
K
R
H
L
F
F
A
N
I
D
---
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
-----------------------------------------------------------------
311
Blastp_CBE
43.99
39%
25
- C2 -
-
5N3D
2
KAPCA_CRIGR
A:
[1-338]
------------------------------------------------------------------------------------------------------------
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-----------------
S
Q
N
--
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
E
---
T
---
G
---
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
R
F
-
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
-
K
-------
R
V
-
K
G
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
---
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
----
A
D
Q
P
----
I
Q
----
I
Y
E
K
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
---
D
Y
E
-
E
E
-
E
I
-----------------------------------------
-
* C *
-
-
:
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
-
:
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------