@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : STK11_HUMAN: (2020-09-22 )
MEVVDPQQLGMFTEGELMSVGMDTFIHRIDSTEVIYQPRRKRAKLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRWRSMTVVPYLEDLHGADEDEDLFDIEDDIIYTQDFTVPGQVPEEEASHNGQRRGLPKAVCMNGTEAAQLSTKSRAEGRAPNPARKACSASSKIRRLSACKQQ
Atome Classification :
(204 SA)
.........10........20........30........40........50........60...---.....70........80....-...-------------.90-------..----....-------..100.......110.......-120.......130...-....140-.-.-.-.-...150.......160.......170.......180..---..---...---190-.........200.......210.-.-.....220.-......230...--....240.......250...-.--...260.......270...----.--..--.280.----.----.....290......-----.300.......--310-...-.....320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MEVV
D
P
Q
Q
LGMFTE
G
E
L
M
S
V
G
M
D
T
F
I
H
RIDS
T
E
V
I
Y
Q
P
R
R
K
R
A
K
L
I
G
K
Y
L
M
G
D
L
LGEGSY
G
K
V
K
---
E
V
L
D
S
E
T
L
C
R
R
A
V
K
I
L
K
K
K
K
L
-
R
RI-------------PNG-------E
A
----
N
V
K
K
-------
E
I
Q
L
L
R
R
L
R
H
K
N
V
I
Q
L
V
D
V
L
Y
N
-
E
E
K
Q
K
M
Y
M
V
M
E
Y
C
V
C
G
-
M
Q
E
M
L
D
S-V-
P
-
E
-K-RFP
V
C
QAH
G
Y
F
C
Q
L
I
D
G
L
E
Y
L
H
SQG
I
V
HKDIKPG
N
L
L
L
---TT---G
G
T
---
L
---
K
I
SDL
G
V
A
E
A
LHPFAADDTCRTS-Q-GSPAFQP
P
E
-
I
ANGLDTFS
G
F
K
--
V
D
I
W
SA
G
V
T
L
Y
N
ITTGLYPF-E--G
D
N
I
Y
K
L
F
E
N
IGKGSYAIP----G--DC--GP
P
L
S
----
D
----
L
L
K
G
M
L
EYEPAK
R
F
-----
S
I
R
Q
I
R
Q
H
S
W
F
--RK--KHP-PAEAPVPIPPSPD
T
K
D
R
WRS
M
T
V
V
P
Y
L
E
D
LHGADEDEDLFDIED
D
I
I
Y
TQDFTVPGQV
P
E
E
E
ASHNGQRRGL
P
K
A
V
CMNGT
E
A
A
QLSTKSRAEGRAPN
P
A
R
K
AC
S
A
S
S
K
I
R
R
L
S
A
CKQQ
339
HHSearch
99.31
100%
-107
- C1 -
-
2WTK
1
STK11_HUMAN
C:
[5-300]
----------------------------------------------
G
K
Y
L
M
G
D
L
L
G
E
G
S
Y
G
K
V
K
---
E
V
L
D
S
E
T
L
C
R
R
A
V
K
I
L
K
K
K
K
L
-
R
R
I
-------------
P
N
G
-------
E
A
----
N
V
K
K
-------
E
I
Q
L
L
R
R
L
R
H
K
N
V
I
Q
L
V
D
V
L
Y
N
-
E
---
K
M
Y
M
V
M
E
Y
C
V
C
G
-
M
Q
E
M
L
D
S
-
V
-
P
-
E
-
K
-
R
F
P
V
C
Q
A
H
G
Y
F
C
Q
L
I
D
G
L
E
Y
L
H
S
Q
G
I
V
H
K
D
I
K
P
G
N
L
L
L
---
T
T
---
G
G
T
---
L
---
K
I
S
A
L
G
V
A
E
A
L
H
P
F
A
A
D
D
T
C
R
T
S
-
Q
-
G
S
P
A
F
Q
P
P
E
-
I
A
N
G
L
D
T
F
S
G
F
K
--
V
D
I
W
S
A
G
V
T
L
Y
N
I
T
T
G
L
Y
P
F
-
E
--
G
D
N
I
Y
K
L
F
E
N
I
G
K
G
S
Y
A
I
P
----
G
--
D
C
--
G
P
P
L
S
----
D
----
L
L
K
G
M
L
E
Y
E
P
A
K
R
F
-----
S
I
R
Q
I
R
Q
H
S
W
F
--
R
K
--
K
H
P
-
P
-
E
A
P
V
P
I
P
P
S
----
D
R
W
---
T
V
V
P
Y
L
E
-------------------------------------------------------------------------------------------
1
PsiBlast_PDB
99.08
99%
-107
- C1 -
-
2WTK
1
STK11_HUMAN
C:
[5-300]
----------------------------------------------
G
K
Y
L
M
G
D
L
L
G
E
G
S
Y
G
K
V
K
---
E
V
L
D
S
E
T
L
C
R
R
A
V
K
I
L
K
K
K
K
L
-
R
R
I
-------------
P
N
G
-------
E
A
----
N
V
K
K
-------
E
I
Q
L
L
R
R
L
R
H
K
N
V
I
Q
L
V
D
V
L
Y
N
-
E
---
K
M
Y
M
V
M
E
Y
C
V
C
G
-
M
Q
E
M
L
D
S
-
V
-
P
-
E
-
K
-
R
F
P
V
C
Q
A
H
G
Y
F
C
Q
L
I
D
G
L
E
Y
L
H
S
Q
G
I
V
H
K
D
I
K
P
G
N
L
L
L
---
T
T
---
G
G
T
---
L
---
K
I
S
A
L
G
V
A
E
A
L
H
P
F
A
A
D
D
T
C
R
T
S
-
Q
-
G
S
P
A
F
Q
P
P
E
-
I
A
N
G
L
D
T
F
S
G
F
K
--
V
D
I
W
S
A
G
V
T
L
Y
N
I
T
T
G
L
Y
P
F
-
E
--
G
D
N
I
Y
K
L
F
E
N
I
G
K
G
S
Y
A
I
P
----
G
--
D
C
--
G
P
P
L
S
----
D
----
L
L
K
G
M
L
E
Y
E
P
A
K
R
F
-----
S
I
R
Q
I
R
Q
H
S
W
F
--
R
K
--
K
H
P
-
P
-
E
A
P
V
P
I
P
P
S
----
D
R
W
---
T
V
V
P
Y
L
E
-------------------------------------------------------------------------------------------
340
HHSearch
92.38
100%
-110
- C1 -
-
2WTK
1
STK11_HUMAN
F:
[3-298]
--------------------------------------------
L
I
G
K
Y
L
M
G
D
L
L
G
E
G
S
Y
G
K
V
K
---
E
V
L
D
S
E
T
L
C
R
R
A
V
K
I
L
K
K
K
K
L
-
R
R
I
-------------
P
N
G
-------
E
A
----
N
V
K
K
-------
E
I
Q
L
L
R
R
L
R
H
K
N
V
I
Q
L
V
D
V
L
Y
N
------
M
Y
M
V
M
E
Y
C
V
C
G
-
M
Q
E
M
L
D
S
-
V
-
P
-
E
-
K
-
R
F
P
V
C
Q
A
H
G
Y
F
C
Q
L
I
D
G
L
E
Y
L
H
S
Q
G
I
V
H
K
D
I
K
P
G
N
L
L
L
---
T
T
---
G
G
T
---
L
---
K
I
S
A
L
G
V
A
E
A
L
H
P
F
A
A
D
D
T
C
R
T
S
-
Q
-
G
S
P
A
F
Q
P
P
E
-
I
A
N
G
L
D
T
F
S
G
F
K
--
V
D
I
W
S
A
G
V
T
L
Y
N
I
T
T
G
L
Y
P
F
-
E
--
G
----
K
L
F
E
N
I
G
K
G
--
A
I
P
----
G
---------
L
S
----
D
----
L
L
K
G
M
L
E
Y
E
P
A
K
R
F
-----
S
I
R
Q
I
R
Q
H
S
W
F
--
R
K
--
K
H
P
-
P
-
E
A
P
V
P
I
P
P
-----------
T
V
V
P
Y
---------------------------------------------------------------------------------------------
21
Blastp_CBE
92.17
99%
-110
- C1 -
-
2WTK
1
STK11_HUMAN
F:
[3-298]
--------------------------------------------
L
I
G
K
Y
L
M
G
D
L
L
G
E
G
S
Y
G
K
V
K
---
E
V
L
D
S
E
T
L
C
R
R
A
V
K
I
L
K
K
K
K
L
-
R
R
I
-------------
P
N
G
-------
E
A
----
N
V
K
K
-------
E
I
Q
L
L
R
R
L
R
H
K
N
V
I
Q
L
V
D
V
L
Y
N
------
M
Y
M
V
M
E
Y
C
V
C
G
-
M
Q
E
M
L
D
S
-
V
-
P
-
E
-
K
-
R
F
P
V
C
Q
A
H
G
Y
F
C
Q
L
I
D
G
L
E
Y
L
H
S
Q
G
I
V
H
K
D
I
K
P
G
N
L
L
L
---
T
T
---
G
G
T
---
L
---
K
I
S
A
L
G
V
A
E
A
L
H
P
F
A
A
D
D
T
C
R
T
S
-
Q
-
G
S
P
A
F
Q
P
P
E
-
I
A
N
G
L
D
T
F
S
G
F
K
--
V
D
I
W
S
A
G
V
T
L
Y
N
I
T
T
G
L
Y
P
F
-
E
--
G
----
K
L
F
E
N
I
G
K
G
--
A
I
P
----
G
---------
L
S
----
D
----
L
L
K
G
M
L
E
Y
E
P
A
K
R
F
-----
S
I
R
Q
I
R
Q
H
S
W
F
--
R
K
--
K
H
P
-
P
-
E
A
P
V
P
I
P
P
-----------
T
V
V
P
Y
---------------------------------------------------------------------------------------------
3
PsiBlast_PDB
67.11
36%
-43
- C1 -
-
6C9H
2
AAPK1_HUMAN
A:
[13-328]
---------------------------------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
---
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
-
R
S
L
--------------
D
V
-------
V
G
----
K
I
R
R
-------
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
---
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
---
E
L
F
D
Y
-
I
-
C
-
K
-
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
A
---
H
M
N
---
A
---
K
I
A
D
F
G
L
S
N
M
M
---
S
D
G
E
F
L
R
T
S
-
C
-
G
S
P
N
Y
A
A
P
E
-
V
I
S
G
-
R
L
Y
A
G
P
E
--
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-
D
--
D
D
H
V
P
T
L
F
K
K
I
C
D
G
I
F
Y
T
P
----
Q
--
Y
L
--
N
P
S
V
I
----
S
----
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
--
K
Q
--
D
L
P
-
K
Y
L
F
P
------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
66.66
36%
-49
- C1 -
-
5ISO
2
?
A:
[13-368]
---------------------------------------------
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
---
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
-
R
S
L
--------------
D
V
-------
V
G
----
K
I
K
R
-------
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
---
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
---
E
L
F
D
Y
-
I
-
C
-
K
-
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
A
---
H
M
N
---
A
---
K
I
A
D
F
G
L
S
N
M
M
---
S
D
G
E
F
L
R
T
S
-
C
-
G
S
P
N
Y
A
A
P
E
-
V
I
S
G
-
R
L
Y
A
G
P
E
--
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-
D
--
D
E
H
V
P
T
L
F
K
K
I
R
G
G
V
F
Y
I
P
----
E
--
Y
L
--
N
R
S
V
A
----
T
----
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
--
K
Q
--
D
L
P
-
S
Y
L
F
P
------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
66.44
36%
-47
- C1 -
-
4CFH
1
AAPK1_RAT
A:
[32-356]
---------------------------------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
---
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
-
R
S
L
--------------
D
V
-------
V
G
----
K
I
R
R
-------
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
---
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
---
E
L
F
D
Y
-
I
-
C
-
K
-
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
A
---
H
M
N
---
A
---
K
I
A
D
F
G
L
S
N
M
M
---
S
D
G
E
F
L
R
T
S
-
C
-
G
S
P
N
Y
A
A
P
E
-
V
I
S
G
-
R
L
Y
A
G
P
E
--
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-
D
--
D
D
H
V
P
T
L
F
K
K
I
C
D
G
I
F
Y
T
P
----
Q
--
Y
L
--
N
P
S
V
I
----
S
----
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
--
K
Q
--
D
L
P
-
K
Y
L
F
P
------------------------------------------------------------------------------------------------------------------
27
Blastp_CBE
65.56
33%
-51
- C1 -
-
4YOM
2
?
B:
[13-305]
-----------------------------------------
H
A
Q
Y
V
G
P
Y
R
L
E
K
T
L
G
K
G
Q
T
G
L
V
K
---
L
G
I
H
C
V
T
C
Q
K
V
A
I
K
I
V
N
R
E
K
L
-
S
E
---------------
S
V
-------
L
M
----
K
V
E
R
-------
E
I
A
I
L
K
L
I
E
H
P
H
V
L
K
L
H
D
V
Y
---
E
N
K
K
Y
L
Y
L
V
L
E
H
V
S
G
G
---
E
L
F
D
Y
-
L
-
V
-
K
-
K
G
R
L
T
P
K
E
A
R
K
F
F
R
Q
I
I
S
A
L
D
F
C
H
S
H
S
I
C
H
R
D
L
K
P
E
N
L
L
L
---
D
E
---
R
N
N
---
I
---
R
I
A
D
F
G
M
A
S
L
Q
---
V
G
D
S
L
L
E
T
S
-
C
-
G
S
P
H
Y
A
C
P
E
-
V
I
R
G
-
E
K
Y
D
G
R
K
--
A
D
V
W
S
C
G
V
I
L
F
A
L
L
V
G
A
L
P
F
-
D
--
D
D
N
L
R
Q
L
L
E
K
V
K
R
G
V
F
H
M
P
----
H
--
F
I
--
P
P
D
C
Q
----
S
----
L
L
R
G
M
I
E
V
D
A
A
R
R
L
-----
T
L
E
H
I
Q
K
H
I
W
Y
IG
G
K
--
N
-----------------
K
V
Q
I
R
S
L
---
P
S
L
E
D
I
-----
D
P
D
V
L
D
------------------------------------------------------------------------------
2
PsiBlast_PDB
64.99
37%
-48
- C1 -
-
4REW
1
AAPK1_HUMAN
A:
[5-394]
---------------------------------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
---
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
-
R
S
L
--------------
D
V
-------
V
G
----
K
I
R
R
-------
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
---
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
---
E
L
F
D
Y
-
I
-
C
-
K
-
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
A
---
H
M
N
---
A
---
K
I
A
D
F
G
L
S
N
M
M
---
S
D
G
E
F
L
R
T
S
-
C
-
G
S
P
N
Y
A
A
P
E
-
V
I
S
G
-
R
L
Y
A
G
P
E
--
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-
D
--
D
D
H
V
P
T
L
F
K
K
I
C
D
G
I
F
Y
T
P
----
Q
--
Y
L
--
N
P
S
V
I
----
S
----
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
S
I
K
D
I
R
E
H
E
W
F
--
K
Q
--
D
L
P
------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
64.87
36%
-40
- C1 -
-
5T5T
2
AAPK1_RAT
A:
[15-399]
---------------------------------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
---
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
-
R
S
L
--------------
D
V
-------
V
G
----
K
I
R
R
-------
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
---
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
---
E
L
F
D
Y
-
I
-
C
-
K
-
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
A
---
H
M
N
---
A
---
K
I
A
D
F
G
L
S
N
M
M
---
S
D
G
E
F
L
R
T
S
-
C
-
G
S
P
N
Y
A
A
P
E
-
V
I
S
G
-
R
L
Y
A
G
P
E
--
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-
D
--
D
D
H
V
P
T
L
F
K
K
I
C
D
G
I
F
Y
T
P
----
Q
--
Y
L
--
N
P
S
V
I
----
S
----
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
--
K
Q
--
D
L
P
------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
64.31
36%
-44
- C1 -
-
5UFU
2
AAPK1_MOUSE (first)
A:
[15-399]
---------------------------------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
---
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
-
R
S
L
--------------
D
V
-------
V
G
----
K
I
R
R
-------
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
---
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
---
E
L
F
D
Y
-
I
-
C
-
K
-
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
A
---
H
M
N
---
A
---
K
I
A
D
F
G
L
S
N
M
M
---
S
D
G
E
F
L
R
T
S
-
C
-
G
S
P
N
Y
A
A
P
E
-
V
I
S
G
-
R
L
Y
A
G
P
E
--
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-
D
--
D
D
H
V
P
T
L
F
K
K
I
C
D
G
I
F
Y
T
P
----
Q
--
Y
L
--
N
P
S
V
I
----
S
----
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
--
K
Q
--
D
L
P
------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
64.26
36%
-45
- C1 -
-
5KQ5
2
?
A:
[15-404]
---------------------------------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
---
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
-
R
S
L
--------------
D
V
-------
V
G
----
K
I
R
R
-------
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
---
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
---
E
L
F
D
Y
-
I
-
C
-
K
-
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
A
---
H
M
N
---
A
---
K
I
A
D
F
G
L
S
N
M
M
---
S
D
G
E
F
L
R
T
S
-
C
-
G
S
P
N
Y
A
A
P
E
-
V
I
S
G
-
R
L
Y
A
G
P
E
--
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-
D
--
D
D
H
V
P
T
L
F
K
K
I
C
D
G
I
F
Y
T
P
----
Q
--
Y
L
--
N
P
S
V
I
----
S
----
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
--
K
Q
--
D
L
P
------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
63.93
36%
-46
- C1 -
-
4QFR
2
?
A:
[15-406]
---------------------------------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
---
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
-
R
S
L
--------------
D
V
-------
V
G
----
K
I
R
R
-------
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
---
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
---
E
L
F
D
Y
-
I
-
C
-
K
-
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
A
---
H
M
N
---
A
---
K
I
A
D
F
G
L
S
N
M
M
---
S
D
G
E
F
L
R
T
S
-
C
-
G
S
P
N
Y
A
A
P
E
-
V
I
S
G
-
R
L
Y
A
G
P
E
--
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-
D
--
D
D
H
V
P
T
L
F
K
K
I
C
D
G
I
F
Y
T
P
----
Q
--
Y
L
--
N
P
S
V
I
----
S
----
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
--
K
Q
--
D
L
P
------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
63.93
36%
-45
- C1 -
-
4QFG
1
A:
[15-402]
---------------------------------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
---
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
-
R
S
L
--------------
D
V
-------
V
G
----
K
I
R
R
-------
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
---
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
---
E
L
F
D
Y
-
I
-
C
-
K
-
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
A
---
H
M
N
---
A
---
K
I
A
D
F
G
L
S
N
M
M
---
S
D
G
E
F
L
R
T
S
-
C
-
G
S
P
N
Y
A
A
P
E
-
V
I
S
G
-
R
L
Y
A
G
P
E
--
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-
D
--
D
D
H
V
P
T
L
F
K
K
I
C
D
G
I
F
Y
T
P
----
Q
--
Y
L
--
N
P
S
V
I
----
S
----
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
--
K
Q
--
D
L
P
------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
63.86
36%
-46
- C1 -
-
4QFS
2
AAPK1_RAT
A:
[15-406]
---------------------------------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
---
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
-
R
S
L
--------------
D
V
-------
V
G
----
K
I
R
R
-------
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
---
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
---
E
L
F
D
Y
-
I
-
C
-
K
-
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
A
---
H
M
N
---
A
---
K
I
A
D
F
G
L
S
N
M
M
---
S
D
G
E
F
L
R
T
S
-
C
-
G
S
P
N
Y
A
A
P
E
-
V
I
S
G
-
R
L
Y
A
G
P
E
--
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-
D
--
D
D
H
V
P
T
L
F
K
K
I
C
D
G
I
F
Y
T
P
----
Q
--
Y
L
--
N
P
S
V
I
----
S
----
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
--
K
Q
--
D
L
P
------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
63.84
36%
-45
- C1 -
-
6E4U
2
AAPK1_RAT
A:
[15-402]
---------------------------------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
---
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
-
R
S
L
--------------
D
V
-------
V
G
----
K
I
R
R
-------
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
---
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
---
E
L
F
D
Y
-
I
-
C
-
K
-
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
A
---
H
M
N
---
A
---
K
I
A
D
F
G
L
S
N
M
M
---
S
D
G
E
F
L
R
T
S
-
C
-
G
S
P
N
Y
A
A
P
E
-
V
I
S
G
-
R
L
Y
A
G
P
E
--
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-
D
--
D
D
H
V
P
T
L
F
K
K
I
C
D
G
I
F
Y
T
P
----
Q
--
Y
L
--
N
P
S
V
I
----
S
----
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
--
K
Q
--
D
L
P
------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
63.57
36%
-47
- C1 -
-
6E4T
2
?
A:
[15-406]
---------------------------------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
---
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
-
R
S
L
--------------
D
V
-------
V
G
----
K
I
R
R
-------
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
---
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
---
E
L
F
D
Y
-
I
-
C
-
K
-
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
A
---
H
M
N
---
A
---
K
I
A
D
F
G
L
S
N
M
M
---
S
D
G
E
F
L
R
T
S
-
C
-
G
S
P
N
Y
A
A
P
E
-
V
I
S
G
-
R
L
Y
A
G
P
E
--
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-
D
--
D
D
H
V
P
T
L
F
K
K
I
C
D
G
I
F
Y
T
P
----
Q
--
Y
L
--
N
P
S
V
I
----
S
----
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
--
K
Q
--
D
L
P
------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
63.03
36%
-41
- C1 -
-
6E4W
2
?
A:
[15-406]
---------------------------------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
---
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
-
R
S
L
--------------
D
V
-------
V
G
----
K
I
R
R
-------
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
---
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
---
E
L
F
D
Y
-
I
-
C
-
K
-
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
A
---
H
M
N
---
A
---
K
I
A
D
F
G
L
S
N
M
M
---
S
D
G
E
F
L
R
T
S
-
C
-
G
S
P
N
Y
A
A
P
E
-
V
I
S
G
-
R
L
Y
A
G
P
E
--
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-
D
--
D
D
H
V
P
T
L
F
K
K
I
C
D
G
I
F
Y
T
P
----
Q
--
Y
L
--
N
P
S
V
I
----
S
----
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
--
K
Q
--
D
L
P
------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
63.03
36%
-47
- C1 -
-
4RER
2
AAPK1_HUMAN
A:
[5-346]
---------------------------------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
---
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
-
R
S
L
--------------
D
V
-------
V
G
----
K
I
R
R
-------
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
---
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
---
E
L
F
D
Y
-
I
-
C
-
K
-
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
A
---
H
M
N
---
A
---
K
I
A
D
F
G
L
S
N
M
M
---
S
D
G
E
F
L
R
T
S
-
C
-
G
S
P
N
Y
A
A
P
E
-
V
I
S
G
-
R
L
Y
A
G
P
E
--
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-
D
--
D
D
H
V
P
T
L
F
K
K
I
C
D
G
I
F
Y
T
P
----
Q
--
Y
L
--
N
P
S
V
I
----
S
----
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
S
I
K
D
I
R
E
H
E
W
F
--
K
Q
--
D
L
P
------------------------------------------------------------------------------------------------------------------------
22
Blastp_CBE
62.72
36%
-64
- C1 -
-
3AQV
1
AAPK2_HUMAN
A:
[10-275]
---------------------------------------------
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
---
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
-
R
S
L
--------------
D
V
-------
V
G
----
K
I
K
R
-------
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
---
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
---
E
L
F
D
Y
-
I
-
C
-
K
-
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
A
---
H
M
N
---
A
---
K
I
A
D
F
G
L
S
N
M
M
---
S
D
G
E
F
L
--------
P
N
Y
A
A
P
E
-
V
I
S
G
-
R
L
Y
A
G
P
E
--
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-
D
--
D
E
H
V
P
T
L
F
K
K
I
R
G
G
V
F
Y
I
P
----
E
--
Y
L
--
N
R
S
V
A
----
T
----
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
--
K
Q
--
D
L
P
-
S
Y
L
F
P
------------------------------------------------------------------------------------------------------------------
142
Blastp_CBE
61.13
32%
-39
- C1 -
-
4IEB
1
?
A:
[56-323]
-----------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
---
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
-----------------
T
D
K
-------
E
S
-----
L
L
R
-------
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
--
F
F
-
E
D
K
G
Y
F
Y
L
V
M
E
V
Y
T
G
G
---
E
L
F
D
E
-
I
I
S
-
R
-
K
-
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
ESK
S
K
---
D
A
N
---
I
---
R
I
I
D
F
G
L
S
T
---
H
F
E
A
S
K
K
M
K
D
K
-
I
-
G
T
A
Y
Y
I
A
P
E
-
V
L
H
G
--
T
Y
D
E
-
K
--
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
PQW-
K
--
K
V
--
S
E
S
A
K
----
D
----
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
I
---
Q
--
T
Y
T
-
K
E
Q
I
S
V
D
V
P
S
-------------------------------------------------------------------------------------------------------------
69
Blastp_CBE
61.02
31%
-45
- C1 -
-
5ES1
1
MARK4_HUMAN
A:
[14-297]
---------------------------------------------
V
G
N
Y
R
L
L
R
T
I
G
K
G
N
F
A
K
V
K
---
L
A
R
H
I
L
T
G
R
E
V
A
I
K
I
I
D
K
T
Q
L
-
N
---------------
P
S
S
-------
L
Q
----
K
L
F
R
-------
E
V
R
I
M
K
G
L
N
H
P
N
I
V
K
L
F
E
V
I
---
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
A
G
---
E
V
F
D
Y
L
V
-
S
-
H
-
G
-
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
H
Y
C
H
Q
K
N
I
V
H
R
D
L
K
A
E
N
L
L
L
---
D
A
---
E
A
N
---
I
---
K
I
A
D
F
G
F
S
---
N
---------------
S
P
P
Y
A
A
P
E
-
L
F
Q
G
-
K
K
Y
D
G
P
E
--
V
D
I
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
-
D
--
G
H
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
V
P
----
F
--
Y
M
--
S
T
D
C
E
----
S
----
I
L
R
R
F
L
V
L
N
P
A
K
R
C
-----
T
L
E
Q
I
M
K
D
K
W
I
--
N
I
--
G
Y
E
-
G
E
E
L
K
P
Y
T
E
P
E
E
D
F
G
D
T
K
R
I
E
V
M
V
-----------------------------------------------------------------------------------------------
56
Blastp_CBE
60.88
34%
-64
- C1 -
-
6BRC
1
KKCC2_HUMAN
B:
[4-290]
---------------------------------------------
L
N
Q
Y
T
L
K
D
E
I
G
K
G
S
Y
G
V
V
K
---
L
A
Y
N
E
N
D
N
T
Y
Y
A
M
K
V
L
S
K
K
K
L
-
I
R
------------------------------
Q
V
Y
Q
-------
E
I
A
I
L
K
K
L
D
H
P
N
V
V
K
L
V
E
V
L
D
D
-
P
N
E
D
H
L
Y
M
V
F
E
L
V
N
Q
G
---
P
V
M
E
V
-
P
-
T
-
L
-
K
-
P
L
S
E
D
Q
A
R
F
Y
F
Q
D
L
I
K
G
I
E
Y
L
H
Y
Q
K
I
I
H
R
D
I
K
P
S
N
L
L
V
---
G
E
---
D
G
H
---
I
---
K
I
A
D
F
G
V
S
N
E
F
K
--
G
S
D
A
L
L
S
N
T
-
V
-
G
T
P
A
F
M
A
P
E
S
L
S
E
T
R
K
I
F
S
G
K
A
--
L
D
V
W
A
M
G
V
T
L
Y
C
F
V
F
G
Q
C
P
F
-
M
--
D
E
R
I
M
C
L
H
S
K
I
K
S
Q
A
L
E
F
P
----
D
QP
D
I
--
A
E
D
L
K
----
D
----
L
I
T
R
M
L
D
K
N
P
E
S
R
I
-----
V
V
P
E
I
K
L
H
P
W
V
--
T
R
-----------------------------------------------------------------------------------------------------------------------------
45
Blastp_CBE
60.29
33%
-43
- C1 -
-
5EAK
1
MARK2_HUMAN
A:
[14-297]
---------------------------------------------
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
---
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
T
Q
L
-
N
---------------
S
S
S
-------
L
Q
----
K
L
F
R
-------
E
V
R
I
M
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
---
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
---
E
V
F
D
Y
L
V
-
A
-
H
-
G
-
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
---
D
A
---
D
M
N
---
I
---
K
I
A
D
F
G
F
S
--------------
F
-
C
-
G
S
P
P
Y
A
A
P
E
-
L
F
Q
G
-
K
K
Y
D
G
P
E
--
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
-
D
--
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
I
P
----
F
--
Y
M
--
S
T
D
C
E
----
N
----
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
R
W
M
--
N
V
--
G
H
E
-
D
D
E
L
K
P
Y
V
E
P
L
P
D
Y
K
D
P
R
R
T
E
L
M
V
-----------------------------------------------------------------------------------------------
46
Blastp_CBE
60.20
33%
-38
- C1 -
-
5KZ8
1
MARK2_HUMAN
B:
[32-315]
---------------------------------------------
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
---
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
T
Q
L
-
N
---------------
S
S
S
-------
L
Q
----
K
L
F
R
-------
E
V
R
I
M
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
---
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
---
E
V
F
D
Y
L
V
-
A
-
H
-
G
-
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
---
D
A
---
D
M
N
---
I
---
K
I
A
D
F
---------------------
G
S
P
P
Y
A
A
P
E
-
L
F
Q
G
-
K
K
Y
D
G
P
E
--
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
-
D
--
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
I
P
----
F
--
Y
M
--
S
T
D
C
E
----
N
----
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
R
W
M
--
N
V
--
G
H
E
-
D
D
E
L
K
P
Y
V
E
P
L
P
D
Y
K
D
P
R
R
T
E
L
M
V
-----------------------------------------------------------------------------------------------
44
Blastp_CBE
60.08
33%
-34
- C1 -
-
5EAK
1
MARK2_HUMAN
B:
[15-297]
----------------------------------------------
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
---
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
T
Q
L
-
N
---------------
S
S
S
-------
L
Q
----
K
L
F
R
-------
E
V
R
I
M
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
---
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
---
E
V
F
D
Y
L
V
-
A
-
H
-
G
-
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
---
D
A
---
D
M
N
---
I
---
K
I
A
D
F
G
----------------
F
-
C
-
G
S
P
P
Y
A
A
P
E
-
L
F
Q
G
-
K
K
Y
D
G
P
E
--
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
-
D
--
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
I
P
----
F
--
Y
M
--
S
T
D
C
E
----
N
----
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
R
W
M
--
N
V
--
G
H
E
-
D
D
E
L
K
P
Y
V
E
P
L
P
D
Y
K
D
P
R
R
T
E
L
M
V
-----------------------------------------------------------------------------------------------
47
Blastp_CBE
59.82
33%
-46
- C1 -
-
5KZ8
1
MARK2_HUMAN
A:
[32-315]
---------------------------------------------
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
---
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
T
Q
L
-
N
---------------
S
S
S
-------
L
Q
----
K
L
F
R
-------
E
V
R
I
M
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
---
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
---
E
V
F
D
Y
L
V
-
A
-
H
-
G
-
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
---
D
A
---
D
M
N
---
I
---
K
I
A
D
F
G
------------------
C
-
G
S
P
P
Y
A
A
P
E
-
L
F
Q
G
-
K
K
Y
D
G
P
E
--
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
-
D
--
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
I
P
----
F
--
Y
M
--
S
T
D
C
E
----
N
----
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
R
W
M
--
N
V
--
G
H
E
-
D
D
E
L
K
P
Y
V
E
P
L
P
D
Y
K
D
P
R
R
T
E
L
M
V
-----------------------------------------------------------------------------------------------
32
Blastp_CBE
59.74
33%
-40
- C1 -
-
4CZU
3
CIPKN_ARATH
A:
[10-277]
---------------------------------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
---
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
-
L
K
--------------
N
K
M
-------
I
A
----
Q
I
K
R
-------
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
---
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
---
E
L
F
D
K
-
I
-
S
-
S
-
N
G
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
---
D
A
---
N
G
A
---
L
---
K
V
S
D
F
G
L
S
A
L
P
Q
Q
V
R
E
D
G
L
L
H
D
T
-
C
-
G
T
P
N
Y
V
A
P
E
-
V
I
N
N
-
K
G
Y
D
G
A
K
--
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
-
E
--
D
S
N
L
T
S
L
Y
K
K
I
F
K
A
E
F
T
C
P
----
P
--
W
F
--
S
A
S
A
K
----
K
----
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
E
V
I
E
N
E
W
F
--
K
K
--
G
Y
-------------------------------------------------------------------------------------------------------------------------
31
Blastp_CBE
59.34
33%
-41
- C1 -
-
4CZU
3
CIPKN_ARATH
B:
[10-278]
---------------------------------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
---
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
-
L
K
--------------
N
K
M
-------
I
A
----
Q
I
K
R
-------
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
---
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
---
E
L
F
D
K
-
I
-
S
-
S
-
N
G
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
---
D
A
---
N
G
A
---
L
---
K
V
S
D
F
G
L
S
A
L
P
Q
Q
V
R
E
D
G
L
L
H
D
T
-
C
-
G
T
P
N
Y
V
A
P
E
-
V
I
N
N
-
K
G
Y
D
G
A
K
--
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
-
E
--
D
S
N
L
T
S
L
Y
K
K
I
F
K
A
E
F
T
C
P
----
P
--
W
F
--
S
A
S
A
K
----
K
----
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
E
V
I
E
N
E
W
F
--
K
K
--
G
Y
-------------------------------------------------------------------------------------------------------------------------
349
HHSearch
58.31
33%
-60
- C1 -
-
5TVT
1
MELK_HUMAN
A:
[7-268]
-------------------------------------------
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
---
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
-----------------
G
S
D
-------
L
P
----
R
I
K
T
-------
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
---
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
-----
Q
-
D
-
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
---
Y
H
K
---
L
---
K
L
I
D
F
G
L
C
A
K
----------------
G
S
L
A
Y
A
A
P
E
-
L
I
Q
G
K
-
S
Y
L
G
S
E
--
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
-
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
----
K
--
W
L
--
S
P
S
S
I
----
L
----
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
--
M
Q
--
D
Y
-------------------------------------------------------------------------------------------------------------------------
24
Blastp_CBE
58.31
34%
-32
- C1 -
-
4CZT
4
CIPKN_ARATH
D:
[10-276]
---------------------------------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
---
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
-
L
K
--------------
N
K
M
-------
I
A
----
Q
I
K
R
-------
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
---
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
---
E
L
F
D
K
-
I
-
S
-
S
-
N
G
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
---
D
A
---
N
G
A
---
L
---
K
V
S
D
F
G
L
S
A
L
P
Q
Q
V
R
E
D
G
L
L
H
T
T
-
C
-
G
T
P
N
Y
V
A
P
E
-
V
I
N
N
-
K
G
Y
D
G
A
K
--
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
-
E
--
D
S
N
L
T
S
L
Y
K
K
I
F
K
A
E
F
T
C
P
----
P
--
W
F
--
S
A
S
A
K
----
K
----
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
E
V
I
E
N
E
W
F
--
K
K
--
G
Y
-------------------------------------------------------------------------------------------------------------------------
86
Blastp_CBE
58.17
33%
-70
- C1 -
-
5MAF
2
MELK_HUMAN
A:
[7-268]
-------------------------------------------
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
---
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
--
D
L
-------------
P
R
---------------
I
K
T
-------
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
---
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
---
E
L
F
D
Y
-
I
I
S
-
Q
-
D
-
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
---
Y
H
K
---
L
---
K
L
I
D
F
G
L
C
-
A
K
----------------
S
L
A
Y
A
A
P
E
-
L
I
Q
G
-
K
--
L
G
S
E
--
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
-
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
----
K
--
W
L
--
S
P
S
S
I
----
L
----
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
--
M
Q
--
D
Y
-------------------------------------------------------------------------------------------------------------------------
48
Blastp_CBE
58.15
33%
-41
- C1 -
-
5KZ7
1
MARK2_HUMAN
B:
[32-315]
---------------------------------------------
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
---
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
T
Q
L
-
N
---------------
S
S
S
-------
L
Q
----
K
L
F
R
-------
E
V
R
I
M
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
---
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
---
E
V
F
D
Y
L
V
-
A
-
H
-
G
-
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
---
D
A
---
D
M
N
---
I
---
K
I
A
D
F
---------------------
G
S
P
P
Y
A
A
P
E
-
L
F
Q
G
-
K
--
D
G
P
E
--
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
-
D
----
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
I
P
----
F
--
Y
M
--
S
T
D
C
E
----
N
----
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
R
W
M
--
N
V
--
G
H
E
-
D
D
E
L
K
P
Y
V
E
P
L
P
D
Y
K
D
P
R
R
T
E
L
M
V
-----------------------------------------------------------------------------------------------
88
Blastp_CBE
57.97
33%
-67
- C1 -
-
4BL1
1
MELK_HUMAN
A:
[7-268]
-------------------------------------------
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
---
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
---
L
-------------
P
R
---------------
I
K
T
-------
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
---
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
---
E
L
F
D
Y
-
I
I
S
-
Q
-
D
-
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
---
Y
H
K
---
L
---
K
L
I
D
F
G
L
C
-
A
K
----------------
S
L
A
Y
A
A
P
E
-
L
I
Q
G
-
K
---
G
S
E
--
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
-
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
----
K
--
W
L
--
S
P
S
S
I
----
L
----
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
--
M
Q
--
D
Y
-------------------------------------------------------------------------------------------------------------------------
23
Blastp_CBE
57.87
36%
-74
- C1 -
-
6BX6
1
AAPK2_HUMAN
A:
[10-274]
---------------------------------------------
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
---
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
-
R
S
L
--------------
D
V
-------
V
G
----
K
I
K
R
-------
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
---
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
---
E
L
F
D
Y
-
I
-
C
-
K
-
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
A
---
H
M
N
---
A
---
K
I
A
D
F
G
L
S
---------------------
N
Y
A
A
P
E
--------
Y
A
G
P
E
--
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-
D
--
D
E
H
V
P
T
L
F
K
K
I
R
G
G
V
F
Y
I
P
----
E
--
Y
L
--
N
R
S
V
A
----
T
----
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
--
K
Q
--
D
L
P
-
S
Y
L
F
-------------------------------------------------------------------------------------------------------------------
90
Blastp_CBE
57.83
33%
-69
- C1 -
-
4BKY
1
MELK_HUMAN
A:
[7-268]
-------------------------------------------
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
---
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
--
D
L
-------------
P
R
---------------
I
K
T
-------
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
---
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
---
E
L
F
D
Y
-
I
I
S
-
Q
-
D
-
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
---
Y
H
K
---
L
---
K
L
I
D
F
G
L
C
-
A
-----------------
S
L
A
Y
A
A
P
E
-
L
I
Q
G
-
K
---
G
S
E
--
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
-
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
----
K
--
W
L
--
S
P
S
S
I
----
L
----
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
--
M
Q
--
D
Y
-------------------------------------------------------------------------------------------------------------------------
73
Blastp_CBE
57.64
33%
-65
- C1 -
-
5IHA
1
MELK_HUMAN
A:
[5-266]
-------------------------------------------
E
L
L
K
Y
Y
E
L
H
E
T
I
G
----
A
K
V
K
---
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
------------------
R
---------------
I
K
T
-------
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
---
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
---
E
L
F
D
Y
-
I
I
S
-
Q
-
D
-
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
---
Y
H
K
---
L
---
K
L
I
D
F
G
L
C
-
A
K
----------------
S
L
A
Y
A
A
P
E
-
L
I
Q
G
-
K
S
Y
L
G
S
E
--
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
-
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
----
K
--
W
L
--
S
P
S
S
I
----
L
----
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
--
M
Q
--
D
Y
-------------------------------------------------------------------------------------------------------------------------
61
Blastp_CBE
57.34
34%
-18
- C1 -
-
6BLE
2
KKCC2_HUMAN
A:
[4-290]
---------------------------------------------
L
N
Q
Y
T
L
K
D
E
I
G
K
G
S
Y
G
V
V
K
---
L
A
Y
N
E
N
D
N
T
Y
Y
A
M
K
V
L
S
K
K
K
L
-
I
R
Q
------------------------
I
E---
Q
V
Y
Q
-------
E
I
A
I
L
K
K
L
D
H
P
N
V
V
K
L
V
E
V
L
D
D
-
P
N
E
D
H
L
Y
M
V
F
E
L
V
N
Q
G
---
P
V
M
E
V
-
P
-
T
-
L
-
K
-
P
L
S
E
D
Q
A
R
F
Y
F
Q
D
L
I
K
G
I
E
Y
L
H
Y
Q
K
I
I
H
R
D
I
K
P
S
N
L
L
V
---
G
E
---
D
G
H
---
I
---
K
I
A
D
F
G
V
S
N
E
F
K
--
G
S
D
A
L
L
S
N
T
-
V
-
G
T
P
A
F
M
A
P
E
S
L
S
E
T
R
K
I
F
S
G
K
A
--
L
D
V
W
A
M
G
V
T
L
Y
C
F
V
F
G
Q
C
P
F
-
M
--
D
E
R
I
M
C
L
H
S
K
I
K
S
Q
A
L
E
F
P
----
D
QP
D
I
--
A
E
D
L
K
----
D
----
L
I
T
R
M
L
D
K
N
P
E
S
R
I
-----
V
V
P
E
I
K
L
H
P
W
V
--
T
R
-----------------------------------------------------------------------------------------------------------------------------
89
Blastp_CBE
57.31
33%
-73
- C1 -
-
4BKZ
1
MELK_HUMAN
A:
[7-268]
-------------------------------------------
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
---
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
---
L
-------------
P
R
---------------
I
K
T
-------
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
---
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
---
E
L
F
D
Y
-
I
I
S
-
Q
-
D
-
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
---
Y
H
K
---
L
---
K
L
I
D
F
G
L
C
-
A
-----------------
S
L
A
Y
A
A
P
E
-
L
I
Q
G
-----
G
S
E
--
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
-
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
----
K
--
W
L
--
S
P
S
S
I
----
L
----
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
--
M
Q
--
D
Y
-------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
57.26
33%
-36
- C1 -
-
4CZT
3
CIPKN_ARATH
A:
[10-274]
---------------------------------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
---
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
-
L
K
--------------
N
K
M
-------
I
A
----
Q
I
K
R
-------
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
---
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
---
E
L
F
D
K
-
I
-
S
-
S
-
N
G
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
---
D
A
---
N
G
A
---
L
---
K
V
S
D
F
G
L
S
A
L
P
Q
Q
V
R
E
D
G
L
L
H
T
T
-
C
-
G
T
P
N
Y
V
A
P
E
-
V
I
N
N
-
K
G
Y
D
G
A
K
--
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
-
E
--
D
S
N
L
T
S
L
Y
K
K
I
F
K
A
E
F
T
C
P
----
P
--
W
F
--
S
A
S
A
K
----
K
----
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
E
V
I
E
N
E
W
F
--
K
K
--
G
Y
-------------------------------------------------------------------------------------------------------------------------
62
Blastp_CBE
57.13
34%
-21
- C1 -
-
6BKU
2
KKCC2_HUMAN
A:
[4-290]
---------------------------------------------
L
N
Q
Y
T
L
K
D
E
I
G
K
G
S
Y
G
V
V
K
---
L
A
Y
N
E
N
D
N
T
Y
Y
A
M
K
V
L
S
K
K
K
L
-
I
R
Q
AG----------------------
I
E---
Q
V
Y
Q
-------
E
I
A
I
L
K
K
L
D
H
P
N
V
V
K
L
V
E
V
L
D
D
-
P
N
E
D
H
L
Y
M
V
F
E
L
V
N
Q
G
---
P
V
M
E
V
-
P
-
T
-
L
-
K
-
P
L
S
E
D
Q
A
R
F
Y
F
Q
D
L
I
K
G
I
E
Y
L
H
Y
Q
K
I
I
H
R
D
I
K
P
S
N
L
L
V
---
G
E
---
D
G
H
---
I
---
K
I
A
D
F
G
V
S
N
E
F
K
--
G
S
D
A
L
L
S
N
T
-
V
-
G
T
P
A
F
M
A
P
E
S
L
S
E
T
R
K
I
F
S
G
K
A
--
L
D
V
W
A
M
G
V
T
L
Y
C
F
V
F
G
Q
C
P
F
-
M
--
D
E
R
I
M
C
L
H
S
K
I
K
S
Q
A
L
E
F
P
----
D
QP
D
I
--
A
E
D
L
K
----
D
----
L
I
T
R
M
L
D
K
N
P
E
S
R
I
-----
V
V
P
E
I
K
L
H
P
W
V
--
T
R
-----------------------------------------------------------------------------------------------------------------------------
57
Blastp_CBE
57.03
34%
-20
- C1 -
-
6BRC
1
KKCC2_HUMAN
A:
[4-290]
---------------------------------------------
L
N
Q
Y
T
L
K
D
E
I
G
K
G
S
Y
G
V
V
K
---
L
A
Y
N
E
N
D
N
T
Y
Y
A
M
K
V
L
S
K
K
K
L
-
I
R
Q
------------------------
I
E---
Q
V
Y
Q
-------
E
I
A
I
L
K
K
L
D
H
P
N
V
V
K
L
V
E
V
L
D
D
-
P
N
E
D
H
L
Y
M
V
F
E
L
V
N
Q
G
---
P
V
M
E
V
-
P
-
T
-
L
-
K
-
P
L
S
E
D
Q
A
R
F
Y
F
Q
D
L
I
K
G
I
E
Y
L
H
Y
Q
K
I
I
H
R
D
I
K
P
S
N
L
L
V
---
G
E
---
D
G
H
---
I
---
K
I
A
D
F
G
V
S
N
E
F
K
--
G
S
D
A
L
L
S
N
T
-
V
-
G
T
P
A
F
M
A
P
E
S
L
S
E
T
R
K
I
F
S
G
K
A
--
L
D
V
W
A
M
G
V
T
L
Y
C
F
V
F
G
Q
C
P
F
-
M
--
D
E
R
I
M
C
L
H
S
K
I
K
S
Q
A
L
E
F
P
----
D
QP
D
I
--
A
E
D
L
K
----
D
----
L
I
T
R
M
L
D
K
N
P
E
S
R
I
-----
V
V
P
E
I
K
L
H
P
W
V
--
T
R
-----------------------------------------------------------------------------------------------------------------------------
49
Blastp_CBE
57.01
33%
-47
- C1 -
-
5KZ7
1
MARK2_HUMAN
A:
[32-315]
---------------------------------------------
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
---
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
T
Q
L
-
N
---------------
S
S
S
-------
L
Q
----
K
L
F
R
-------
E
V
R
I
M
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
---
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
---
E
V
F
D
Y
L
V
-
A
-
H
-
G
-
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
---
D
A
---
D
M
N
---
I
---
K
I
A
D
F
---------------------
G
S
P
P
Y
A
A
P
E
-
L
F
Q
G
-
K
--
D
G
P
E
--
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
-
D
----
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
I
P
----
F
--
Y
M
--
S
T
D
C
E
----
N
----
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
R
W
M
--
N
V
--
G
H
E
-
D
D
E
L
K
P
Y
V
E
P
L
P
D
Y
K
D
P
R
R
T
E
L
M
V
-----------------------------------------------------------------------------------------------
81
Blastp_CBE
56.68
34%
-27
- C1 -
-
5YV9
3
KKCC2_HUMAN
A:
[12-298]
---------------------------------------------
L
N
Q
Y
T
L
K
D
E
I
G
K
G
S
Y
G
V
V
K
---
L
A
Y
N
E
N
D
N
T
Y
Y
A
M
K
V
L
S
K
K
-----------------------------
P
I
E---
Q
V
Y
Q
-------
E
I
A
I
L
K
K
L
D
H
P
N
V
V
K
L
V
E
V
L
D
D
-
P
N
E
D
H
L
Y
M
V
F
E
L
V
N
Q
G
---
P
V
M
E
V
-
P
-
T
-
L
-
K
-
P
L
S
E
D
Q
A
R
F
Y
F
Q
D
L
I
K
G
I
E
Y
L
H
Y
Q
K
I
I
H
R
D
I
K
P
S
N
L
L
V
---
G
E
---
D
G
H
---
I
---
K
I
A
D
F
G
V
S
N
E
F
K
--
G
S
D
A
L
L
S
N
T
-
V
-
G
T
P
A
F
M
A
P
E
S
L
S
E
T
R
K
I
F
S
G
K
A
--
L
D
V
W
A
M
G
V
T
L
Y
C
F
V
F
G
Q
C
P
F
-
M
--
D
E
R
I
M
-
L
H
S
K
I
K
S
Q
A
L
E
F
P
----
D
QP
D
I
--
A
E
D
L
K
----
D
----
L
I
T
R
M
L
D
K
N
P
E
S
R
I
-----
V
V
P
E
I
K
L
H
P
W
V
--
T
R
-----------------------------------------------------------------------------------------------------------------------------
30
Blastp_CBE
56.57
33%
-34
- C1 -
-
4CZU
3
CIPKN_ARATH
C:
[10-277]
---------------------------------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
---
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
-
L
K
--------------
N
K
M
-------
I
A
----
Q
I
K
R
-------
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
---
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
---
E
L
F
D
K
-
I
-
S
-
S
-
N
G
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
---
D
A
---
N
G
A
---
L
---
K
V
S
D
F
G
L
S
A
L
P
Q
Q
V
R
E
D
G
L
L
H
D
T
-
C
-
G
T
P
N
Y
V
A
P
E
-
V
I
N
N
-
K
G
Y
D
G
A
K
--
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
-
E
--
D
S
N
L
T
S
L
Y
K
K
I
F
K
A
E
F
T
C
P
----
P
--
W
F
--
S
A
S
A
K
----
K
----
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
E
V
I
E
N
E
W
F
--
K
K
--
G
Y
-------------------------------------------------------------------------------------------------------------------------
74
Blastp_CBE
56.30
33%
-63
- C1 -
-
5IH9
1
MELK_HUMAN
A:
[5-266]
-------------------------------------------
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
---
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
----
L
-------------
P
R
---------------
I
K
T
-------
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
---
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
---
E
L
F
D
Y
-
I
I
S
-
Q
-
D
-
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
---
Y
H
K
---
L
---
K
L
I
D
F
G
L
C
-
A
K
----------------
S
L
A
Y
A
A
P
E
-
L
I
Q
G
-
K
S
Y
L
G
S
E
--
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
-
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
----
K
--
W
L
--
S
P
S
S
I
----
L
----
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
--
M
Q
--
D
Y
-------------------------------------------------------------------------------------------------------------------------
82
Blastp_CBE
56.28
34%
-26
- C1 -
-
5YV8
5
KKCC2_HUMAN
A:
[12-298]
---------------------------------------------
L
N
Q
Y
T
L
K
D
E
I
G
K
G
S
Y
G
V
V
K
---
L
A
Y
N
E
N
D
N
T
Y
Y
A
M
K
V
L
S
K
K
-----------------------------
P
I
E---
Q
V
Y
Q
-------
E
I
A
I
L
K
K
L
D
H
P
N
V
V
K
L
V
E
V
L
D
D
-
P
N
E
D
H
L
Y
M
V
F
E
L
V
N
Q
G
---
P
V
M
E
V
-
P
-
T
-
L
-
K
-
P
L
S
E
D
Q
A
R
F
Y
F
Q
D
L
I
K
G
I
E
Y
L
H
Y
Q
K
I
I
H
R
D
I
K
P
S
N
L
L
V
---
G
E
---
D
G
H
---
I
---
K
I
A
D
F
G
V
S
N
E
F
K
--
G
S
D
A
L
L
S
N
T
-
V
-
G
T
P
A
F
M
A
P
E
S
L
S
E
T
R
K
I
F
S
G
K
A
--
L
D
V
W
A
M
G
V
T
L
Y
C
F
V
F
G
Q
C
P
F
-
M
--
D
E
R
I
M
-
L
H
S
K
I
K
S
Q
A
L
E
F
P
----
D
QP
D
I
--
A
E
D
L
K
----
D
----
L
I
T
R
M
L
D
K
N
P
E
S
R
I
-----
V
V
P
E
I
K
L
H
P
W
V
--
T
R
-----------------------------------------------------------------------------------------------------------------------------
85
Blastp_CBE
56.21
33%
-65
- C1 -
-
5MAG
3
MELK_HUMAN
A:
[7-268]
-------------------------------------------
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
-
A
K
V
K
---
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
--
D
L
-------------
P
R
---------------
I
K
T
-------
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
---
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
---
E
L
F
D
Y
-
I
I
S
-
Q
-
D
-
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
---
Y
H
K
---
L
---
K
L
I
D
F
G
L
C
-
A
K
----------------
S
L
A
Y
A
A
P
E
-
L
I
Q
G
-
K
--
L
G
S
E
--
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
-
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
----
K
--
W
L
--
S
P
S
S
I
----
L
----
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
--
M
Q
--
D
Y
-------------------------------------------------------------------------------------------------------------------------
95
Blastp_CBE
56.07
33%
-70
- C1 -
-
5TWY
1
MELK_HUMAN
A:
[7-268]
-------------------------------------------
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
---
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
---
D
L
-------------
P
R
---------------
I
K
T
-------
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
---
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
---
E
L
F
D
Y
-
I
I
S
-
Q
-
D
-
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
---
Y
H
K
---
L
---
K
L
I
D
F
G
L
-----------------
C
-
G
S
L
A
Y
A
A
P
E
-
L
I
Q
G
-
K
---
G
S
E
--
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
-
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
----
K
--
W
L
--
S
P
S
S
I
----
L
----
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
--
M
Q
--
D
Y
-------------------------------------------------------------------------------------------------------------------------
187
Blastp_CBE
56.06
31%
-30
- C1 -
-
3HX4
3
?
A:
[57-323]
-----------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
---
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
---------------------
D
K
-------
E
S
-----
L
L
R
-------
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
--
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
---
E
L
F
D
E
-
I
I
S
-
R
-
K
-
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
ESK
S
K
---
D
A
N
---
I
---
R
I
I
D
F
G
L
S
T
---
H
F
E
A
S
K
K
M
K
D
K
-
I
-
G
T
A
Y
Y
I
A
P
E
-
V
L
H
G
--
T
Y
D
E
-
K
--
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
LPQW
K
--
K
V
--
S
E
S
A
K
----
D
----
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
I
---
Q
--
T
Y
T
-
K
E
Q
I
S
V
D
V
P
S
-------------------------------------------------------------------------------------------------------------
75
Blastp_CBE
55.90
33%
-60
- C1 -
-
5IH8
1
MELK_HUMAN
A:
[5-266]
-------------------------------------------
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
---
A
K
V
K
---
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
---
D
L
-------------
P
R
---------------
I
K
T
-------
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
---
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
---
E
L
F
D
Y
-
I
I
S
-
Q
-
D
-
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
---
Y
H
K
---
L
---
K
L
I
D
F
G
L
C
-
A
K
----------------
S
L
A
Y
A
A
P
E
-
L
I
Q
G
-
K
S
Y
L
G
S
E
--
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
-
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
----
K
--
W
L
--
S
P
S
S
I
----
L
----
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
--
M
Q
--
D
Y
-------------------------------------------------------------------------------------------------------------------------
160
Blastp_CBE
55.88
31%
-36
- C1 -
-
3V5P
1
?
A:
[33-451]
-----------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
---
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
-
K
Q
K
-------------
T
D
K
-------
E
S
-----
L
L
R
-------
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
--
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
---
E
L
F
D
E
-
I
I
S
-
R
-
K
-
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
ESK
S
K
---
D
A
N
---
I
---
R
I
I
D
F
G
L
S
T
---
H
F
E
A
S
K
K
M
K
D
K
-
I
-
G
T
A
Y
Y
I
A
P
E
-
V
L
H
G
--
T
Y
D
E
-
K
--
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
LPQW
K
--
K
V
--
S
E
S
A
K
----
D
----
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
I
--
Q
---
T
Y
T
-
K
E
Q
I
S
V
D
V
P
S
-------------------------------------------------------------------------------------------------------------
59
Blastp_CBE
55.87
34%
-18
- C1 -
-
6BQP
2
KKCC2_HUMAN
A:
[4-290]
---------------------------------------------
L
N
Q
Y
T
L
K
D
E
I
G
K
G
S
Y
G
V
V
K
---
L
A
Y
N
E
N
D
N
T
Y
Y
A
M
K
V
L
S
K
K
K
L
-
I
R
-------------------------
I
E---
Q
V
Y
Q
-------
E
I
A
I
L
K
K
L
D
H
P
N
V
V
K
L
V
E
V
L
D
D
-
P
N
E
D
H
L
Y
M
V
F
E
L
V
N
Q
G
---
P
V
M
E
V
-
P
-
T
-
L
-
K
-
P
L
S
E
D
Q
A
R
F
Y
F
Q
D
L
I
K
G
I
E
Y
L
H
Y
Q
K
I
I
H
R
D
I
K
P
S
N
L
L
V
---
G
E
---
D
G
H
---
I
---
K
I
A
D
F
G
V
S
N
E
F
K
--
G
S
D
A
L
L
S
N
T
-
V
-
G
T
P
A
F
M
A
P
E
S
L
S
E
T
R
K
I
F
S
G
K
A
--
L
D
V
W
A
M
G
V
T
L
Y
C
F
V
F
G
Q
C
P
F
-
M
--
D
E
R
I
M
C
L
H
S
K
I
K
S
Q
A
L
E
F
P
----
D
QP
D
I
--
A
E
D
L
K
----
D
----
L
I
T
R
M
L
D
K
N
P
E
S
R
I
-----
V
V
P
E
I
K
L
H
P
W
V
--
T
R
-----------------------------------------------------------------------------------------------------------------------------
162
Blastp_CBE
55.45
31%
-39
- C1 -
-
3UPZ
1
?
A:
[33-451]
-----------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
---
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
-
K
Q
K
-------------
T
D
K
-------
E
S
-----
L
L
R
-------
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
--
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
---
E
L
F
D
E
-
I
I
S
-
R
-
K
-
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
ESK
S
K
---
D
A
N
---
I
---
R
I
I
D
F
G
L
S
T
---
H
F
E
A
S
K
K
M
K
D
K
-
I
-
G
T
A
Y
Y
I
A
P
E
-
V
L
H
G
--
T
Y
D
E
-
K
--
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
LPQW
K
--
K
V
--
S
E
S
A
K
----
D
----
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
I
--
Q
---
T
Y
T
-
K
E
Q
I
S
V
D
V
P
S
-------------------------------------------------------------------------------------------------------------
76
Blastp_CBE
55.28
33%
-60
- C1 -
-
6GVX
2
MELK_HUMAN
B:
[10-271]
-------------------------------------------
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
---
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
--
S
D
L
-------------
P
R
---------------
I
K
T
-------
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
---
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
---
E
L
F
D
Y
-
I
I
S
-
Q
-
D
-
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
---
Y
H
K
---
L
---
K
L
I
D
F
G
L
C
-
A
K
P
--------------
G
S
L
A
Y
A
A
P
E
-
L
I
Q
G
-----
G
S
E
--
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
-
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
----
K
--
W
L
--
S
P
S
S
I
----
L
----
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
--
M
Q
--
D
Y
-------------------------------------------------------------------------------------------------------------------------
60
Blastp_CBE
55.20
34%
2
- C1 -
-
6BQL
2
KKCC2_HUMAN
A:
[4-290]
---------------------------------------------
L
N
Q
Y
T
L
K
D
E
I
G
K
G
S
Y
G
V
V
K
---
L
A
Y
N
E
N
D
N
T
Y
Y
A
M
K
V
L
S
K
K
K
L
-
I
R
Q
AGFPRRPIQ----
P
R
G
-------
P
I
E---
Q
V
Y
Q
-------
E
I
A
I
L
K
K
L
D
H
P
N
V
V
K
L
V
E
V
L
D
D
-
P
N
E
D
H
L
Y
M
V
F
E
L
V
N
Q
G
---
P
V
M
E
V
-
P
-
T
-
L
-
K
-
P
L
S
E
D
Q
A
R
F
Y
F
Q
D
L
I
K
G
I
E
Y
L
H
Y
Q
K
I
I
H
R
D
I
K
P
S
N
L
L
V
---
G
E
---
D
G
H
---
I
---
K
I
A
D
F
G
V
S
N
E
F
K
--
G
S
D
A
L
L
S
N
T
-
V
-
G
T
P
A
F
M
A
P
E
S
L
S
E
T
R
K
I
F
S
G
K
A
--
L
D
V
W
A
M
G
V
T
L
Y
C
F
V
F
G
Q
C
P
F
-
M
--
D
E
R
I
M
C
L
H
S
K
I
K
S
Q
A
L
E
F
P
----
D
QP
D
I
--
A
E
D
L
K
----
D
----
L
I
T
R
M
L
D
K
N
P
E
S
R
I
-----
V
V
P
E
I
K
L
H
P
W
V
--
T
R
-----------------------------------------------------------------------------------------------------------------------------
66
Blastp_CBE
55.18
34%
-23
- C1 -
-
2ZV2
1
KKCC2_HUMAN
A:
[12-298]
---------------------------------------------
L
N
Q
Y
T
L
K
D
E
I
G
K
--
Y
G
V
V
K
---
L
A
Y
N
E
N
D
N
T
Y
Y
A
M
K
V
L
S
K
K
-------------------------------E---
Q
V
Y
Q
-------
E
I
A
I
L
K
K
L
D
H
P
N
V
V
K
L
V
E
V
L
D
D
-
P
N
E
D
H
L
Y
M
V
F
E
L
V
N
Q
G
---
P
V
M
E
V
-
P
-
T
-
L
-
K
-
P
L
S
E
D
Q
A
R
F
Y
F
Q
D
L
I
K
G
I
E
Y
L
H
Y
Q
K
I
I
H
R
D
I
K
P
S
N
L
L
V
---
G
E
---
D
G
H
---
I
---
K
I
A
D
F
G
V
S
N
E
F
K
--
G
S
D
A
L
L
S
N
T
-
V
-
G
T
P
A
F
M
A
P
E
S
L
S
E
T
R
K
I
F
S
G
K
A
--
L
D
V
W
A
M
G
V
T
L
Y
C
F
V
F
G
Q
C
P
F
-
M
--
D
E
R
I
M
C
L
H
S
K
I
K
S
Q
A
L
E
F
P
----
D
QP
D
I
--
A
E
D
L
K
----
D
----
L
I
T
R
M
L
D
K
N
P
E
S
R
I
-----
V
V
P
E
I
K
L
H
P
W
V
--
T
R
-----------------------------------------------------------------------------------------------------------------------------
169
Blastp_CBE
55.05
31%
-35
- C1 -
-
3I7B
4
?
A:
[33-302]
-----------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
---
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
-
K
Q
K
-------------
T
D
K
-------
E
S
-----
L
L
R
-------
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
--
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
---
E
L
F
D
E
-
I
I
S
-
R
-
K
-
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
ESK
S
K
---
D
A
N
---
I
---
R
I
I
D
F
G
L
S
T
---
H
F
E
A
S
K
K
M
K
D
K
-
I
-
G
T
A
Y
Y
I
A
P
E
-
V
L
H
G
--
T
Y
D
E
-
K
--
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
LPQW
K
--
K
V
--
S
E
S
A
K
----
D
----
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
I
--
Q
---
T
Y
T
-
K
E
Q
I
S
V
D
V
P
S
-------------------------------------------------------------------------------------------------------------
68
Blastp_CBE
55.05
33%
-12
- C1 -
-
4CQG
1
MELK_MOUSE
A:
[6-292]
-------------------------------------------
E
L
L
K
Y
Y
E
L
Y
E
T
I
G
T
G
G
F
A
K
V
K
LAC
H
V
L
T
G
E
M
V
---
A
I
K
I
M
D
K
N
A
L
G
S
D
L
-------------
P
R
---------------
V
K
T
-------
E
I
D
A
L
K
S
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
---
E
T
K
N
K
I
F
M
V
L
E
Y
C
P
G
G
---
E
L
F
D
Y
-
I
I
S
-
Q
-
D
-
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
L
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
---
N
H
K
---
L
---
K
L
I
D
F
G
L
C
-
A
K
-------------
C
-
G
S
L
A
Y
A
A
P
E
-
L
I
Q
------
G
S
E
--
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
-
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
E
V
P
----
K
--
W
L
--
S
P
S
S
I
----
L
----
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
R
N
L
L
N
H
P
W
V
--
M
Q
--
D
Y
S
C
P
V
E
W
Q
S
K
T
P
L
T
H
L
D
E
D
C
V
T
E
L
S
V
------------------------------------------------------------------------------------------------
80
Blastp_CBE
55.03
34%
-20
- C1 -
-
5YVA
4
KKCC2_HUMAN
A:
[12-298]
---------------------------------------------
L
N
Q
Y
T
L
K
D
E
I
G
K
G
S
Y
G
V
V
K
---
L
A
Y
N
E
N
D
N
T
Y
Y
A
M
K
V
L
S
K
K
-----------------------------
P
I
E---
Q
V
Y
Q
-------
E
I
A
I
L
K
K
L
D
H
P
N
V
V
K
L
V
E
V
L
D
D
-
P
N
E
D
H
L
Y
M
V
F
E
L
V
N
Q
G
---
P
V
M
E
V
-
P
-
T
-
L
-
K
-
P
L
S
E
D
Q
A
R
F
Y
F
Q
D
L
I
K
G
I
E
Y
L
H
Y
Q
K
I
I
H
R
D
I
K
P
S
N
L
L
V
---
G
E
---
D
G
H
---
I
---
K
I
A
D
F
G
V
S
N
E
F
K
--
G
S
D
A
L
L
S
N
T
-
V
-
G
T
P
A
F
M
A
P
E
S
L
S
E
T
R
K
I
F
S
G
K
A
--
L
D
V
W
A
M
G
V
T
L
Y
C
F
V
F
G
Q
C
P
F
-
M
--
D
E
R
I
M
-
L
H
S
K
I
K
S
Q
A
L
E
F
P
----
D
QP
D
I
--
A
E
D
L
K
----
D
----
L
I
T
R
M
L
D
K
N
P
E
S
R
I
-----
V
V
P
E
I
K
L
H
P
W
V
--
T
R
-----------------------------------------------------------------------------------------------------------------------------
78
Blastp_CBE
54.82
34%
-18
- C1 -
-
5YVC
5
KKCC2_HUMAN
A:
[12-298]
---------------------------------------------
L
N
Q
Y
T
L
K
D
E
I
G
K
G
S
Y
G
V
V
K
---
L
A
Y
N
E
N
D
N
T
Y
Y
A
M
K
V
L
S
K
K
-----------------------------
P
I
E---
Q
V
Y
Q
-------
E
I
A
I
L
K
K
L
D
H
P
N
V
V
K
L
V
E
V
L
D
D
-
P
N
E
D
H
L
Y
M
V
F
E
L
V
N
Q
G
---
P
V
M
E
V
-
P
-
T
-
L
-
K
-
P
L
S
E
D
Q
A
R
F
Y
F
Q
D
L
I
K
G
I
E
Y
L
H
Y
Q
K
I
I
H
R
D
I
K
P
S
N
L
L
V
---
G
E
---
D
G
H
---
I
---
K
I
A
D
F
G
V
S
N
E
F
K
--
G
S
D
A
L
L
S
N
T
-
V
-
G
T
P
A
F
M
A
P
E
S
L
S
E
T
R
K
I
F
S
G
K
A
--
L
D
V
W
A
M
G
V
T
L
Y
C
F
V
F
G
Q
C
P
F
-
M
--
D
E
R
I
M
-
L
H
S
K
I
K
S
Q
A
L
E
F
P
----
D
QP
D
I
--
A
E
D
L
K
----
D
----
L
I
T
R
M
L
D
K
N
P
E
S
R
I
-----
V
V
P
E
I
K
L
H
P
W
V
--
T
R
-----------------------------------------------------------------------------------------------------------------------------
165
Blastp_CBE
54.69
31%
-40
- C1 -
-
3T3U
5
?
A:
[33-310]
-----------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
---
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
-
K
Q
K
-------------
T
D
K
-------
E
S
-----
L
L
R
-------
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
--
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
---
E
L
F
D
E
-
I
I
S
-
R
-
K
-
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
ESK
S
K
---
D
A
N
---
I
---
R
I
I
D
F
G
L
S
T
---
H
F
E
A
S
K
K
M
K
D
K
-
I
-
G
T
A
Y
Y
I
A
P
E
-
V
L
H
G
--
T
Y
D
E
-
K
--
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
LPQW
K
--
K
V
--
S
E
S
A
K
----
D
----
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
I
--
Q
---
T
Y
T
-
K
E
Q
I
S
V
D
V
P
S
-------------------------------------------------------------------------------------------------------------
168
Blastp_CBE
54.62
31%
-37
- C1 -
-
3N51
3
?
A:
[33-314]
-----------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
---
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
-
K
Q
K
-------------
T
D
K
-------
E
S
-----
L
L
R
-------
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
--
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
---
E
L
F
D
E
-
I
I
S
-
R
-
K
-
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
ESK
S
K
---
D
A
N
---
I
---
R
I
I
D
F
G
L
S
T
---
H
F
E
A
S
K
K
M
K
D
K
-
I
-
G
T
A
Y
Y
I
A
P
E
-
V
L
H
G
--
T
Y
D
E
-
K
--
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
LPQW
K
--
K
V
--
S
E
S
A
K
----
D
----
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
I
--
Q
---
T
Y
T
-
K
E
Q
I
S
V
D
V
P
S
-------------------------------------------------------------------------------------------------------------
79
Blastp_CBE
54.51
34%
-19
- C1 -
-
5YVB
6
KKCC2_HUMAN
A:
[12-298]
---------------------------------------------
L
N
Q
Y
T
L
K
D
E
I
G
K
G
S
Y
G
V
V
K
---
L
A
Y
N
E
N
D
N
T
Y
Y
A
M
K
V
L
S
K
K
-----------------------------
P
I
E---
Q
V
Y
Q
-------
E
I
A
I
L
K
K
L
D
H
P
N
V
V
K
L
V
E
V
L
D
D
-
P
N
E
D
H
L
Y
M
V
F
E
L
V
N
Q
G
---
P
V
M
E
V
-
P
-
T
-
L
-
K
-
P
L
S
E
D
Q
A
R
F
Y
F
Q
D
L
I
K
G
I
E
Y
L
H
Y
Q
K
I
I
H
R
D
I
K
P
S
N
L
L
V
---
G
E
---
D
G
H
---
I
---
K
I
A
D
F
G
V
S
N
E
F
K
--
G
S
D
A
L
L
S
N
T
-
V
-
G
T
P
A
F
M
A
P
E
S
L
S
E
T
R
K
I
F
S
G
K
A
--
L
D
V
W
A
M
G
V
T
L
Y
C
F
V
F
G
Q
C
P
F
-
M
--
D
E
R
I
M
-
L
H
S
K
I
K
S
Q
A
L
E
F
P
----
D
QP
D
I
--
A
E
D
L
K
----
D
----
L
I
T
R
M
L
D
K
N
P
E
S
R
I
-----
V
V
P
E
I
K
L
H
P
W
V
--
T
R
-----------------------------------------------------------------------------------------------------------------------------
91
Blastp_CBE
54.43
33%
-72
- C1 -
-
5TX3
2
MELK_HUMAN
B:
[10-271]
-------------------------------------------
E
L
L
K
Y
Y
E
L
H
E
T
I
G
-----
K
V
K
---
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
--------------------------------------
K
T
-------
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
---
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
---
E
L
F
D
Y
-
I
I
S
-
Q
-
D
-
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
---
Y
H
K
---
L
---
K
L
I
D
----------------------
G
S
L
A
Y
A
A
P
E
-
L
I
Q
G
----
L
G
S
E
--
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
-
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
----
K
--
W
L
--
S
P
S
S
I
----
L
----
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
--
M
Q
--
D
Y
-------------------------------------------------------------------------------------------------------------------------
65
Blastp_CBE
54.40
34%
8
- C1 -
-
5UY6
1
KKCC2_HUMAN
A:
[4-290]
---------------------------------------------
L
N
Q
Y
T
L
K
D
E
I
G
K
G
S
Y
G
V
V
K
---
L
A
Y
N
E
N
D
N
T
Y
Y
A
M
K
V
L
S
K
K
K
L
-
I
R
Q
AGFPRRPPPGCIQ
P
R
G
-------
P
I
E---
Q
V
Y
Q
-------
E
I
A
I
L
K
K
L
D
H
P
N
V
V
K
L
V
E
V
L
D
D
-
P
N
E
D
H
L
Y
M
V
F
E
L
V
N
Q
G
---
P
V
M
E
V
-
P
-
T
-
L
-
K
-
P
L
S
E
D
Q
A
R
F
Y
F
Q
D
L
I
K
G
I
E
Y
L
H
Y
Q
K
I
I
H
R
D
I
K
P
S
N
L
L
V
---
G
E
---
D
G
H
---
I
---
K
I
A
D
F
G
V
S
N
E
F
K
--
G
S
D
A
L
L
S
N
T
-
V
-
G
T
P
A
F
M
A
P
E
S
L
S
E
T
R
K
I
F
S
G
K
A
--
L
D
V
W
A
M
G
V
T
L
Y
C
F
V
F
G
Q
C
P
F
-
M
--
D
E
R
I
M
C
L
H
S
K
I
K
S
Q
A
L
E
F
P
----
D
QP
D
I
--
A
E
D
L
K
----
D
----
L
I
T
R
M
L
D
K
N
P
E
S
R
I
-----
V
V
P
E
I
K
L
H
P
W
V
--
T
R
-----------------------------------------------------------------------------------------------------------------------------
198
Blastp_CBE
53.98
31%
-22
- C1 -
-
4Y5Q
1
?
A:
[29-324]
-----------------------------------------------------
M
L
G
K
G
S
F
G
E
V
L
---
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
-
K
N
---------------
K
D
-------
T
S
----
T
I
L
R
-------
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
---
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
---
E
L
F
D
E
-
I
I
K
-
R
-
K
-
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
---
E
S
---
K
E
K
DCD
I
---
K
I
I
D
F
G
L
S
T
C
---
F
Q
Q
N
T
---
D
R
-
I
-
G
T
A
Y
Y
I
A
P
E
-
V
L
R
G
--
T
Y
D
E
-
K
--
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
-
Y
--
G
K
N
E
Y
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
----
L
--
P
Q
--
W
R
T
I
S
DDAK
D
----
L
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
A
T
Q
C
L
E
H
P
W
I
--
Q
K
YS
S
E
T
-
P
T
I
S
D
L
P
S
L
E
S
A
M
T
N
I
R
------------------------------------------------------------------------------------------------------
243
Blastp_CBE
53.96
31%
-62
- C1 -
-
2CN5
1
CHK2_HUMAN
A:
[17-285]
-----------------------------------------------
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
---
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
R
-----------------------------------
N
V
E
T
-------
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
---
Y
Y
I
V
L
E
L
M
E
G
G
---
E
L
F
D
K
-
V
-
V
G
N
-
K
-
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
QEE
D
C
L
---
I
---
K
I
T
D
F
G
H
S
K
I
L
---
G
E
T
S
L
M
R
T
L
-
C
-
G
T
P
T
Y
L
A
P
E
-
V
L
V
S
V
G
T
-
A
G
Y
N
RA
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
----
P
--
E
V
--
W
A
E
V
S
EKAL
D
----
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
--
Q
------------------------------------------------------------------------------------------------------------------------------
92
Blastp_CBE
53.96
33%
-70
- C1 -
-
5TX3
2
MELK_HUMAN
A:
[10-271]
-------------------------------------------
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
---
A
K
V
K
---
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
------------------------------------
I
K
T
-------
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
---
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
---
E
L
F
D
Y
-
I
I
S
-
Q
-
D
-
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
---
Y
H
K
---
L
---
K
L
I
D
F
G
L
-------------------
G
S
L
A
Y
A
A
P
E
-
L
I
Q
G
-
K
---
G
S
E
--
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
-
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
----
K
--
W
L
--
S
P
S
S
I
----
L
----
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
--
M
Q
--
D
Y
-------------------------------------------------------------------------------------------------------------------------
67
Blastp_CBE
53.67
34%
-18
- C1 -
-
4BFM
1
MELK_MOUSE
A:
[6-278]
-------------------------------------------
E
L
L
K
Y
Y
E
L
Y
E
T
I
G
T
G
G
F
A
K
V
K
LAC
H
V
L
T
G
E
M
V
---
A
I
K
I
M
D
K
N
A
L
G
S
D
L
-------------
P
R
---------------
V
K
T
-------
E
I
D
A
L
K
S
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
---
E
T
K
N
K
I
F
M
V
L
E
Y
C
P
G
G
---
E
L
F
D
Y
-
I
I
S
-
Q
-
D
-
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
L
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
---
N
H
K
---
L
---
K
L
I
D
F
G
L
C
-
A
K
-------------
C
-
G
S
L
A
Y
A
A
P
E
-
L
I
Q
------
G
S
E
--
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
-
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
E
V
P
----
K
--
W
L
--
S
P
S
S
I
----
L
----
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
R
N
L
L
N
H
P
W
V
--
M
Q
--
D
Y
S
C
P
V
E
W
Q
S
K
T
P
--------------------------------------------------------------------------------------------------------------
214
Blastp_CBE
53.52
31%
-61
- C1 -
-
2YCS
1
CHK2_HUMAN
A:
[11-279]
-----------------------------------------------
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
---
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------------------
N
V
E
T
-------
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
---
Y
Y
I
V
L
E
L
M
E
G
G
---
E
L
F
D
K
-
V
-
V
G
N
-
K
-
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
QEE
D
C
L
---
I
---
K
I
T
D
F
G
H
S
K
I
L
-----
T
S
L
M
R
T
L
-
C
-
G
T
P
T
Y
L
A
P
E
-
V
L
V
S
V
G
T
-
A
G
Y
N
RA
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
----
P
--
E
V
--
W
A
E
V
S
EKAL
D
----
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
--
Q
------------------------------------------------------------------------------------------------------------------------------
126
Blastp_CBE
53.34
37%
-74
- C1 -
-
6CD6
1
KKCC1_HUMAN
D:
[75-290]
--------------------------------------------------------------------------------------------------------------------------
V
Y
Q
-------
E
I
A
I
L
K
K
L
D
H
V
N
V
V
K
L
I
E
V
L
D
D
-
P
A
E
D
N
L
Y
L
V
F
D
L
L
R
K
G
---
P
V
M
E
V
-
P
-
C
-
D
-
K
-
P
F
S
E
E
Q
A
R
L
Y
L
R
D
V
I
L
G
L
E
Y
L
H
C
Q
K
I
V
H
R
D
I
K
P
S
N
L
L
L
---
G
D
---
D
G
H
---
V
---
K
I
A
D
F
G
V
S
N
Q
F
E
--
G
N
D
A
Q
L
S
S
T
-
A
-
G
T
P
A
F
M
A
P
E
A
I
S
D
S
G
Q
S
F
S
G
K
A
--
L
D
V
W
A
T
G
V
T
L
Y
C
F
V
Y
G
K
C
P
F
-
I
--
D
D
F
I
L
A
L
H
R
K
I
K
N
E
P
V
V
F
P
----
E
EP
E
I
--
S
E
E
L
K
----
D
----
L
I
L
K
M
L
D
K
N
P
E
T
R
I
-----
G
V
P
D
I
K
L
H
P
W
V
--
T
K
-----------------------------------------------------------------------------------------------------------------------------
225
Blastp_CBE
53.32
31%
-53
- C1 -
-
4BDF
3
CHK2_HUMAN
A:
[17-285]
-----------------------------------------------
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
---
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------------------
N
V
E
T
-------
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
---
Y
Y
I
V
L
E
L
M
E
G
G
---
E
L
F
D
K
-
V
-
V
G
N
-
K
-
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
QEE
D
C
L
---
I
---
K
I
T
D
F
G
H
S
K
I
L
---
G
E
T
S
L
M
R
T
L
-
C
-
G
T
P
T
Y
L
A
P
E
-
V
L
V
S
V
G
T
-
A
G
Y
N
RA
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
----
P
--
E
V
--
W
A
E
V
S
EKAL
D
----
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
--
Q
------------------------------------------------------------------------------------------------------------------------------
209
Blastp_CBE
53.20
31%
-58
- C1 -
-
2YCF
1
CHK2_HUMAN
A:
[11-279]
-----------------------------------------------
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
---
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------------------
N
V
E
T
-------
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
---
Y
Y
I
V
L
E
L
M
E
G
G
---
E
L
F
D
K
-
V
-
V
G
N
-
K
-
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
QEE
D
C
L
---
I
---
K
I
T
D
F
G
H
S
K
I
L
---
G
E
T
S
L
M
R
T
L
-
C
-
G
T
P
T
Y
L
A
P
E
-
V
L
V
S
V
G
T
-
A
G
Y
N
RA
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
----
P
--
E
V
--
W
A
E
V
S
EKAL
D
----
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
--
Q
------------------------------------------------------------------------------------------------------------------------------
224
Blastp_CBE
53.17
31%
-58
- C1 -
-
4BDG
2
CHK2_HUMAN
A:
[17-285]
-----------------------------------------------
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
---
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------------------
N
V
E
T
-------
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
---
Y
Y
I
V
L
E
L
M
E
G
G
---
E
L
F
D
K
-
V
-
V
G
N
-
K
-
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
QEE
D
C
L
---
I
---
K
I
T
D
F
G
H
S
K
I
L
---
G
E
T
S
L
M
R
T
L
-
C
-
G
T
P
T
Y
L
A
P
E
-
V
L
V
S
V
G
T
-
A
G
Y
N
RA
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
----
P
--
E
V
--
W
A
E
V
S
EKAL
D
----
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
--
Q
------------------------------------------------------------------------------------------------------------------------------
64
Blastp_CBE
53.08
34%
13
- C1 -
-
5UYJ
1
KKCC2_HUMAN
A:
[4-290]
---------------------------------------------
L
N
Q
Y
T
L
K
D
E
I
G
K
G
S
Y
G
V
V
K
---
L
A
Y
N
E
N
D
N
T
Y
Y
A
M
K
V
L
S
K
K
K
L
-
I
R
Q
AGFPRRPPCIQ--
P
R
G
-------
P
I
E---
Q
V
Y
Q
-------
E
I
A
I
L
K
K
L
D
H
P
N
V
V
K
L
V
E
V
L
D
D
-
P
N
E
D
H
L
Y
M
V
F
E
L
V
N
Q
G
---
P
V
M
E
V
-
P
-
T
-
L
-
K
-
P
L
S
E
D
Q
A
R
F
Y
F
Q
D
L
I
K
G
I
E
Y
L
H
Y
Q
K
I
I
H
R
D
I
K
P
S
N
L
L
V
---
G
E
---
D
G
H
---
I
---
K
I
A
D
F
G
V
S
N
E
F
K
--
G
S
D
A
L
L
S
N
T
-
V
-
G
T
P
A
F
M
A
P
E
S
L
S
E
T
R
K
I
F
S
G
K
A
--
L
D
V
W
A
M
G
V
T
L
Y
C
F
V
F
G
Q
C
P
F
-
M
--
D
E
R
I
M
C
L
H
S
K
I
K
S
Q
A
L
E
F
P
----
D
QP
D
I
--
A
E
D
L
K
----
D
----
L
I
T
R
M
L
D
K
N
P
E
S
R
I
-----
V
V
P
E
I
K
L
H
P
W
V
--
T
R
-----------------------------------------------------------------------------------------------------------------------------
215
Blastp_CBE
52.90
31%
-56
- C1 -
-
2YCQ
1
CHK2_HUMAN
A:
[11-279]
-----------------------------------------------
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
---
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------------------
N
V
E
T
-------
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
---
Y
Y
I
V
L
E
L
M
E
G
G
---
E
L
F
D
K
-
V
-
V
G
N
-
K
-
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
QEE
D
C
L
---
I
---
K
I
T
D
F
G
H
S
K
I
L
---
G
E
T
S
L
M
R
T
L
-
C
-
G
T
P
T
Y
L
A
P
E
-
V
L
V
S
V
G
T
-
A
G
Y
N
RA
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
----
P
--
E
V
--
W
A
E
V
S
EKAL
D
----
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
--
Q
------------------------------------------------------------------------------------------------------------------------------
128
Blastp_CBE
52.77
37%
-71
- C1 -
-
6CD6
1
KKCC1_HUMAN
B:
[75-290]
--------------------------------------------------------------------------------------------------------------------------
V
Y
Q
-------
E
I
A
I
L
K
K
L
D
H
V
N
V
V
K
L
I
E
V
L
D
D
-
P
A
E
D
N
L
Y
L
V
F
D
L
L
R
K
G
---
P
V
M
E
V
-
P
-
C
-
D
-
K
-
P
F
S
E
E
Q
A
R
L
Y
L
R
D
V
I
L
G
L
E
Y
L
H
C
Q
K
I
V
H
R
D
I
K
P
S
N
L
L
L
---
G
D
---
D
G
H
---
V
---
K
I
A
D
F
G
V
S
N
Q
F
E
--
G
N
D
A
Q
L
S
S
T
-
A
-
G
T
P
A
F
M
A
P
E
A
I
S
-
S
G
Q
S
F
S
G
K
A
--
L
D
V
W
A
T
G
V
T
L
Y
C
F
V
Y
G
K
C
P
F
-
I
--
D
D
F
I
L
A
L
H
R
K
I
K
N
E
P
V
V
F
P
----
E
EP
E
I
--
S
E
E
L
K
----
D
----
L
I
L
K
M
L
D
K
N
P
E
T
R
I
-----
G
V
P
D
I
K
L
H
P
W
V
--
T
K
-----------------------------------------------------------------------------------------------------------------------------
87
Blastp_CBE
52.69
33%
-25
- C1 -
-
5M5A
1
MELK_HUMAN
A:
[7-268]
-------------------------------------------
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
---
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
G
S
D
L
-------------
P
R
---------------
I
K
T
-------
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
---
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
---
E
L
F
D
Y
-
I
I
S
-
Q
-
D
-
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
---
Y
H
K
---
L
---
K
L
I
D
F
G
L
C
-
A
-----------------
S
L
A
Y
A
A
P
E
-
L
I
Q
G
-
K
--
L
G
S
E
--
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
-
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
----
K
--
W
L
--
S
P
S
S
I
----
L
----
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
--
M
Q
--
D
Y
-------------------------------------------------------------------------------------------------------------------------
210
Blastp_CBE
52.67
31%
-56
- C1 -
-
2YCR
1
CHK2_HUMAN
A:
[11-279]
-----------------------------------------------
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
---
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------------------
N
V
E
T
-------
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
---
Y
Y
I
V
L
E
L
M
E
G
G
---
E
L
F
D
K
-
V
-
V
G
N
-
K
-
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
QEE
D
C
L
---
I
---
K
I
T
D
F
G
H
S
K
I
L
---
G
E
T
S
L
M
R
T
L
-
C
-
G
T
P
T
Y
L
A
P
E
-
V
L
V
S
V
G
T
-
A
G
Y
N
RA
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
----
P
--
E
V
--
W
A
E
V
S
EKAL
D
----
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
--
Q
------------------------------------------------------------------------------------------------------------------------------
58
Blastp_CBE
52.61
34%
3
- C1 -
-
6BQQ
1
KKCC2_HUMAN
A:
[4-290]
---------------------------------------------
L
N
Q
Y
T
L
K
D
E
I
G
K
G
S
Y
G
V
V
K
---
L
A
Y
N
E
N
D
N
T
Y
Y
A
M
K
V
L
S
K
K
K
L
-
I
R
-GCIQ---------
P
R
G
-------
P
I
E---
Q
V
Y
Q
-------
E
I
A
I
L
K
K
L
D
H
P
N
V
V
K
L
V
E
V
L
D
D
-
P
N
E
D
H
L
Y
M
V
F
E
L
V
N
Q
G
---
P
V
M
E
V
-
P
-
T
-
L
-
K
-
P
L
S
E
D
Q
A
R
F
Y
F
Q
D
L
I
K
G
I
E
Y
L
H
Y
Q
K
I
I
H
R
D
I
K
P
S
N
L
L
V
---
G
E
---
D
G
H
---
I
---
K
I
A
D
F
G
V
S
N
E
F
K
--
G
S
D
A
L
L
S
N
T
-
V
-
G
T
P
A
F
M
A
P
E
S
L
S
E
T
R
K
I
F
S
G
K
A
--
L
D
V
W
A
M
G
V
T
L
Y
C
F
V
F
G
Q
C
P
F
-
M
--
D
E
R
I
M
C
L
H
S
K
I
K
S
Q
A
L
E
F
P
----
D
Q-
D
I
--
A
E
D
L
K
----
D
----
L
I
T
R
M
L
D
K
N
P
E
S
R
I
-----
V
V
P
E
I
K
L
H
P
W
V
--
T
R
-----------------------------------------------------------------------------------------------------------------------------
70
Blastp_CBE
52.59
33%
-22
- C1 -
-
5TVT
1
MELK_HUMAN
A:
[7-268]
-------------------------------------------
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
---
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
G
S
D
L
-------------
P
R
---------------
I
K
T
-------
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
---
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
---
E
L
F
D
Y
-
I
I
S
-
Q
-
D
-
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
---
Y
H
K
---
L
---
K
L
I
D
F
G
L
C
-
A
K
---------------
G
S
L
A
Y
A
A
P
E
-
L
I
Q
G
-
K
S
Y
L
G
S
E
--
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
-
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
----
K
--
W
L
--
S
P
S
S
I
----
L
----
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
--
M
Q
--
D
Y
-------------------------------------------------------------------------------------------------------------------------
230
Blastp_CBE
52.58
31%
-58
- C1 -
-
4BDA
8
CHK2_HUMAN
A:
[17-285]
-----------------------------------------------
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
---
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------------------
N
V
E
T
-------
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
---
Y
Y
I
V
L
E
L
M
E
G
G
---
E
L
F
D
K
-
V
-
V
G
N
-
K
-
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
QEE
D
C
L
---
I
---
K
I
T
D
F
G
H
S
K
I
L
----
E
T
S
L
M
R
T
L
-
C
-
G
T
P
T
Y
L
A
P
E
-
V
L
V
S
V
G
T
-
A
G
Y
N
RA
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
----
P
--
E
V
--
W
A
E
V
S
EKAL
D
----
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
--
Q
------------------------------------------------------------------------------------------------------------------------------
297
Blastp_CBE
52.55
33%
-20
- C1 -
-
6FC8
1
CHK1_HUMAN
A:
[15-267]
------------------------------------------------------
L
G
E
G
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
-
V
D
C
-------------
P
E
--------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
94
Blastp_CBE
52.53
33%
-66
- C1 -
-
5TWY
1
MELK_HUMAN
B:
[7-268]
-------------------------------------------
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
---
A
K
V
K
---
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
----
D
L
-------------
P
R
---------------
I
K
T
-------
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
---
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
---
E
L
F
D
Y
-
I
I
S
-
Q
-
D
-
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
---
Y
H
K
---
L
---
K
L
I
D
F
G
L
C
--------------------
L
A
Y
A
A
P
E
-
L
I
Q
G
-
K
---
G
S
E
--
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
-
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
----
K
--
W
L
--
S
P
S
S
I
----
L
----
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
--
M
Q
--
D
Y
-------------------------------------------------------------------------------------------------------------------------
216
Blastp_CBE
52.48
31%
-53
- C1 -
-
2W7X
3
CHK2_HUMAN
A:
[11-279]
-----------------------------------------------
E
Y
I
M
S
K
T
L
G
S
G
A
-
G
E
V
K
---
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------------------
N
V
E
T
-------
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
---
Y
Y
I
V
L
E
L
M
E
G
G
---
E
L
F
D
K
-
V
-
V
G
N
-
K
-
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
QEE
D
C
L
---
I
---
K
I
T
D
F
G
H
S
K
I
L
---
G
E
T
S
L
M
R
T
L
-
C
-
G
T
P
T
Y
L
A
P
E
-
V
L
V
S
V
G
T
-
A
G
Y
N
RA
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
----
P
--
E
V
--
W
A
E
V
S
EKAL
D
----
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
--
Q
------------------------------------------------------------------------------------------------------------------------------
217
Blastp_CBE
52.31
31%
-61
- C1 -
-
2W0J
1
CHK2_HUMAN
A:
[11-280]
-----------------------------------------------
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
---
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------------------
N
V
E
T
-------
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
---
Y
Y
I
V
L
E
L
M
E
G
G
---
E
L
F
D
K
-
V
-
V
G
N
-
K
-
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
QEE
D
C
L
---
I
---
K
I
T
D
F
G
H
S
K
I
L
-----
T
S
L
M
R
T
L
-
C
-
G
T
P
T
Y
L
A
P
E
-
V
L
V
S
V
G
T
-
A
G
Y
N
RA
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
----
P
--
E
V
--
W
A
E
V
S
EKAL
D
----
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
--
Q
------------------------------------------------------------------------------------------------------------------------------
227
Blastp_CBE
52.27
31%
-60
- C1 -
-
4BDD
3
CHK2_HUMAN
A:
[17-285]
-----------------------------------------------
E
Y
I
M
S
K
T
L
------
E
V
K
---
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------------------
N
V
E
T
-------
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
---
Y
Y
I
V
L
E
L
M
E
G
G
---
E
L
F
D
K
-
V
-
V
G
N
-
K
-
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
QEE
D
C
L
---
I
---
K
I
T
D
F
G
H
S
K
I
L
-----
T
S
L
M
R
T
L
-
C
-
G
T
P
T
Y
L
A
P
E
-
V
L
V
S
V
G
T
-
A
G
Y
N
RA
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
----
P
--
E
V
--
W
A
E
V
S
EKAL
D
----
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
--
Q
------------------------------------------------------------------------------------------------------------------------------
183
Blastp_CBE
52.24
31%
-36
- C1 -
-
5T6A
1
?
A:
[74-492]
-----------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
---
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
-
K
Q
K
-------------
T
D
K
-------
E
S
-----
L
L
R
-------
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
--
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
---
E
L
F
D
E
-
I
I
S
-
R
-
K
-
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
ESK
S
K
---
D
A
N
---
I
---
R
I
I
D
F
G
L
S
T
---
H
F
E
A
-
K
K
M
K
D
K
-
I
-
G
T
A
Y
Y
I
A
P
E
-
V
L
H
G
--
T
Y
D
E
-
K
--
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
LPQW
K
--
K
V
--
S
E
S
A
K
----
D
----
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
I
---
Q
--
T
Y
T
-
K
E
Q
I
S
V
D
V
P
S
-------------------------------------------------------------------------------------------------------------
127
Blastp_CBE
51.96
37%
-70
- C1 -
-
6CD6
1
KKCC1_HUMAN
C:
[75-290]
--------------------------------------------------------------------------------------------------------------------------
V
Y
Q
-------
E
I
A
I
L
K
K
L
D
H
V
N
V
V
K
L
I
E
V
L
D
D
-
P
A
E
D
N
L
Y
L
V
F
D
L
L
R
K
G
---
P
V
M
E
V
-
P
-
C
-
D
-
K
-
P
F
S
E
E
Q
A
R
L
Y
L
R
D
V
I
L
G
L
E
Y
L
H
C
Q
K
I
V
H
R
D
I
K
P
S
N
L
L
L
---
G
D
---
D
G
H
---
V
---
K
I
A
D
F
G
V
S
N
Q
F
E
--
G
N
D
A
Q
L
S
S
T
-
A
-
G
T
P
A
F
M
A
P
E
A
I
S
-
S
G
Q
S
F
S
G
K
A
--
L
D
V
W
A
T
G
V
T
L
Y
C
F
V
Y
G
K
C
P
F
-
I
--
D
D
F
I
L
A
L
H
R
K
I
K
N
E
P
V
V
F
P
----
E
EP
E
I
--
S
E
E
L
K
----
D
----
L
I
L
K
M
L
D
K
N
P
E
T
R
I
-----
G
V
P
D
I
K
L
H
P
W
V
--
T
K
-----------------------------------------------------------------------------------------------------------------------------
208
Blastp_CBE
51.91
31%
-50
- C1 -
-
2XK9
1
CHK2_HUMAN
A:
[10-278]
-----------------------------------------------
E
Y
I
M
S
K
T
L
G
S
G
A
-
G
E
V
K
---
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------------------
N
V
E
T
-------
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
---
Y
Y
I
V
L
E
L
M
E
G
G
---
E
L
F
D
K
-
V
-
V
G
N
-
K
-
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
QEE
D
C
L
---
I
---
K
I
T
D
F
G
H
S
K
I
L
---
G
E
T
S
L
M
R
T
L
-
C
-
G
T
P
T
Y
L
A
P
E
-
V
L
V
S
V
G
T
-
A
G
Y
N
RA
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
----
P
--
E
V
--
W
A
E
V
S
EKAL
D
----
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
--
Q
------------------------------------------------------------------------------------------------------------------------------
223
Blastp_CBE
51.85
31%
-60
- C1 -
-
4BDH
4
CHK2_HUMAN
A:
[17-285]
-----------------------------------------------
E
Y
I
M
S
K
T
L
------
E
V
K
---
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------------------
N
V
E
T
-------
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
---
Y
Y
I
V
L
E
L
M
E
G
G
---
E
L
F
D
K
-
V
-
V
G
N
-
K
-
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
QEE
D
C
L
---
I
---
K
I
T
D
F
G
H
S
K
I
L
---
G
E
T
S
L
M
R
T
L
-
C
-
G
T
P
T
Y
L
A
P
E
-
V
L
V
S
V
G
T
-
A
G
Y
N
RA
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
----
P
--
E
V
--
W
A
E
V
S
EKAL
D
----
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
--
Q
------------------------------------------------------------------------------------------------------------------------------
186
Blastp_CBE
51.79
31%
-31
- C1 -
-
5DVR
1
?
A:
[74-492]
-----------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
---
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
--
V
-
K
Q
K
-------------
T
D
K
-------
E
S
-----
L
L
R
-------
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
--
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
---
E
L
F
D
E
-
I
I
S
-
R
-
K
-
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
ESK
S
K
---
D
A
N
---
I
---
R
I
I
D
F
G
L
S
T
---
H
F
E
A
-
K
K
M
K
D
K
-
I
-
G
T
A
Y
Y
I
A
P
E
-
V
L
H
G
--
T
Y
D
E
-
K
--
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
LPQW
K
--
K
V
--
S
E
S
A
K
----
D
----
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
I
---
Q
--
T
Y
T
-
K
E
Q
I
S
V
D
V
P
S
-------------------------------------------------------------------------------------------------------------
295
Blastp_CBE
51.78
33%
-19
- C1 -
-
2E9V
1
CHK1_HUMAN
A:
[14-266]
------------------------------------------------------
L
G
E
G
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
-
V
D
C
-------------
P
E
--------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
281
Blastp_CBE
51.52
33%
-16
- C1 -
-
2E9U
1
CHK1_HUMAN
A:
[14-266]
------------------------------------------------------
L
G
E
G
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
-
V
D
C
-------------
P
E
--------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
129
Blastp_CBE
51.50
37%
-70
- C1 -
-
6CD6
1
KKCC1_HUMAN
A:
[75-290]
--------------------------------------------------------------------------------------------------------------------------
V
Y
Q
-------
E
I
A
I
L
K
K
L
D
H
V
N
V
V
K
L
I
E
V
L
D
D
-
P
A
E
D
N
L
Y
L
V
F
D
L
L
R
K
G
---
P
V
M
E
V
-
P
-
C
-
D
-
K
-
P
F
S
E
E
Q
A
R
L
Y
L
R
D
V
I
L
G
L
E
Y
L
H
C
Q
K
I
V
H
R
D
I
K
P
S
N
L
L
L
---
G
D
---
D
G
H
---
V
---
K
I
A
D
F
G
V
S
N
Q
F
E
--
G
N
D
A
Q
L
S
S
T
-
A
-
G
T
P
A
F
M
A
P
E
A
I
--
S
G
Q
S
F
S
G
K
A
--
L
D
V
W
A
T
G
V
T
L
Y
C
F
V
Y
G
K
C
P
F
-
I
--
D
D
F
I
L
A
L
H
R
K
I
K
N
E
P
V
V
F
P
----
E
EP
E
I
--
S
E
E
L
K
----
D
----
L
I
L
K
M
L
D
K
N
P
E
T
R
I
-----
G
V
P
D
I
K
L
H
P
W
V
--
T
K
-----------------------------------------------------------------------------------------------------------------------------
96
Blastp_CBE
51.30
33%
-14
- C1 -
-
5TWL
1
MELK_HUMAN
A:
[7-268]
-------------------------------------------
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
---
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
G
S
D
L
-------------
P
R
---------------
I
K
T
-------
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
---
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
---
E
L
F
D
Y
-
I
I
S
-
Q
-
D
-
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
---
Y
H
K
---
L
---
K
L
I
D
F
G
L
-----------------
C
-
G
S
L
A
Y
A
A
P
E
-
L
I
Q
G
-
K
S
Y
L
G
S
E
--
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
-
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
----
K
--
W
L
--
S
P
S
S
I
----
L
----
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
--
M
Q
--
D
Y
-------------------------------------------------------------------------------------------------------------------------
63
Blastp_CBE
51.30
34%
14
- C1 -
-
5VT1
1
KKCC2_HUMAN
A:
[4-290]
---------------------------------------------
L
N
Q
Y
T
L
K
D
E
I
G
K
G
S
Y
G
V
V
K
---
L
A
Y
N
E
N
D
N
T
Y
Y
A
M
K
V
L
S
K
K
K
L
-
I
R
Q
A-------------
R
G
-------
P
I
E---
Q
V
Y
Q
-------
E
I
A
I
L
K
K
L
D
H
P
N
V
V
K
L
V
E
V
L
D
D
-
P
N
E
D
H
L
Y
M
V
F
E
L
V
N
Q
G
---
P
V
M
E
V
-
P
-
T
-
L
-
K
-
P
L
S
E
D
Q
A
R
F
Y
F
Q
D
L
I
K
G
I
E
Y
L
H
Y
Q
K
I
I
H
R
D
I
K
P
S
N
L
L
V
---
G
E
---
D
G
H
---
I
---
K
I
A
D
F
G
V
S
N
E
F
K
--
G
S
D
A
L
L
S
N
T
-
V
-
G
T
P
A
F
M
A
P
E
S
L
S
---
K
I
F
S
G
K
A
--
L
D
V
W
A
M
G
V
T
L
Y
C
F
V
F
G
Q
C
P
F
-
M
--
D
E
R
I
M
C
L
H
S
K
I
K
S
Q
A
L
E
F
P
----
D
QP
D
I
--
A
E
D
L
K
----
D
----
L
I
T
R
M
L
D
K
N
P
E
S
R
I
-----
V
V
P
E
I
K
L
H
P
W
V
--
T
R
-----------------------------------------------------------------------------------------------------------------------------
104
Blastp_CBE
51.21
33%
-26
- C1 -
-
4UMR
1
MELK_HUMAN
A:
[26-287]
-------------------------------------------
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
---
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
G
S
D
L
-------------
P
R
---------------
I
K
T
-------
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
---
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
---
E
L
F
D
Y
-
I
I
S
-
Q
-
D
-
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
---
Y
H
K
---
L
---
K
L
I
D
F
G
L
-----------------
C
-
G
S
L
A
Y
A
A
P
E
-
L
I
Q
G
-
K
S
Y
L
G
S
E
--
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
-
D
--
D
D
T
A
A
A
L
V
A
K
I
M
R
G
K
Y
D
V
P
----
K
--
W
L
--
S
P
S
S
I
----
L
----
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
--
M
Q
--
D
Y
-------------------------------------------------------------------------------------------------------------------------
221
Blastp_CBE
51.17
31%
-56
- C1 -
-
4BDJ
1
CHK2_HUMAN
A:
[17-285]
-----------------------------------------------
E
Y
I
M
S
K
T
L
-----
G
E
V
K
---
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------------------
N
V
E
T
-------
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
---
Y
Y
I
V
L
E
L
M
E
G
G
---
E
L
F
D
K
-
V
-
V
G
N
-
K
-
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
QEE
D
C
L
---
I
---
K
I
T
D
F
G
H
S
K
I
L
----
E
T
S
L
M
R
T
L
-
C
-
G
T
P
T
Y
L
A
P
E
-
V
L
V
S
V
G
T
-
A
G
Y
N
RA
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
----
P
--
E
V
--
W
A
E
V
S
EKAL
D
----
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
--
Q
------------------------------------------------------------------------------------------------------------------------------
84
Blastp_CBE
51.10
33%
-26
- C1 -
-
5MAH
2
MELK_HUMAN
A:
[7-268]
-------------------------------------------
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
---
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
G
S
D
L
-------------
P
R
---------------
I
K
T
-------
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
---
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
---
E
L
F
D
Y
-
I
I
S
-
Q
-
D
-
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
---
Y
H
K
---
L
---
K
L
I
D
F
G
L
C
-
A
K
----------------
S
L
A
Y
A
A
P
E
-
L
I
Q
G
-
K
--
L
G
S
E
--
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
-
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
----
K
--
W
L
--
S
P
S
S
I
----
L
----
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
--
M
Q
--
D
Y
-------------------------------------------------------------------------------------------------------------------------
327
Blastp_CBE
50.98
33%
-15
- C1 -
-
2X8D
1
CHK1_HUMAN
A:
[15-267]
------------------------------------------------------
L
G
E
G
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
-
V
D
C
-------------
P
E
--------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
242
Blastp_CBE
50.98
31%
-63
- C1 -
-
2CN8
1
CHK2_HUMAN
A:
[17-285]
-----------------------------------------------
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
---
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------------------
N
V
E
T
-------
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
---
Y
Y
I
V
L
E
L
M
E
G
G
---
E
L
F
D
K
-
V
-
V
G
N
-
K
-
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
QEE
D
C
L
---
I
---
K
I
T
D
F
G
H
S
K
I
L
-----
T
S
L
M
R
T
L
-
C
---
P
T
Y
L
A
P
E
-
V
L
V
S
V
G
T
-
A
G
Y
N
RA
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
---
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
----
P
--
E
V
--
W
A
E
V
S
EKAL
D
----
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
--
Q
------------------------------------------------------------------------------------------------------------------------------
296
Blastp_CBE
50.92
33%
-16
- C1 -
-
6FCK
1
CHK1_HUMAN
A:
[15-267]
------------------------------------------------------
L
G
E
G
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
-
V
D
C
-------------
P
E
--------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
276
Blastp_CBE
50.92
33%
-14
- C1 -
-
4FSR
1
CHK1_HUMAN
A:
[14-266]
------------------------------------------------------
L
G
E
G
--
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
-----------------------------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
279
Blastp_CBE
50.75
33%
-17
- C1 -
-
2YWP
1
CHK1_HUMAN
A:
[14-266]
------------------------------------------------------
L
G
E
G
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
-
V
D
C
-------------
P
E
--------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
294
Blastp_CBE
50.71
33%
-20
- C1 -
-
2E9V
1
CHK1_HUMAN
B:
[14-266]
------------------------------------------------------
L
G
E
G
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
-
V
D
C
-------------
P
E
--------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
284
Blastp_CBE
50.71
33%
-13
- C1 -
-
2E9N
1
CHK1_HUMAN
A:
[14-266]
------------------------------------------------------
L
G
E
G
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
-
V
D
C
-------------
P
E
--------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
322
Blastp_CBE
50.65
33%
-16
- C1 -
-
2YDI
1
CHK1_HUMAN
A:
[15-267]
------------------------------------------------------
L
G
E
G
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
-
V
D
C
-------------
P
E
--------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
213
Blastp_CBE
50.61
31%
-56
- C1 -
-
2YIQ
1
CHK2_HUMAN
A:
[11-279]
-----------------------------------------------
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
---
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------------------------------
V
E
T
-------
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
---
Y
Y
I
V
L
E
L
M
E
G
G
---
E
L
F
D
K
-
V
-
V
G
N
-
K
-
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
QEE
D
C
L
---
I
---
K
I
T
D
F
G
H
S
K
I
L
---
G
E
T
S
L
M
R
T
L
-
C
-
G
T
P
T
Y
L
A
P
E
-
V
L
V
S
V
G
T
-
A
G
Y
N
RA
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
----
P
--
E
V
--
W
A
E
V
S
EKAL
D
----
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
--
Q
------------------------------------------------------------------------------------------------------------------------------
236
Blastp_CBE
50.54
31%
-74
- C1 -
-
2XM8
1
CHK2_HUMAN
A:
[17-285]
-----------------------------------------------
E
Y
I
M
S
K
T
L
-----
G
E
V
K
---
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
---------------------------------------
N
V
E
T
-------
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
---
Y
Y
I
V
L
E
L
M
E
G
G
---
E
L
F
D
K
-
V
-
V
G
N
-
K
-
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
QEE
D
C
L
---
I
---
K
I
T
D
F
G
H
S
K
I
L
-----
T
S
L
M
R
T
L
-
C
-
G
---
Y
L
A
P
E
-
V
L
V
S
V
G
T
-
A
G
Y
N
RA
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
----
P
--
E
V
--
W
A
E
V
S
EKAL
D
----
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
--
Q
------------------------------------------------------------------------------------------------------------------------------
272
Blastp_CBE
50.45
33%
-18
- C1 -
-
4FT9
1
CHK1_HUMAN
A:
[14-266]
------------------------------------------------------
L
G
E
G
--
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
---------------------
E
--------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
301
Blastp_CBE
50.18
33%
-24
- C1 -
-
2X8E
1
CHK1_HUMAN
A:
[15-267]
------------------------------------------------------
L
G
E
G
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
----
C
-------------
P
E
--------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
299
Blastp_CBE
50.10
33%
-16
- C1 -
-
2YER
7
CHK1_HUMAN
A:
[15-267]
------------------------------------------------------
L
G
E
G
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
-
V
D
C
-------------
P
E
--------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
245
Blastp_CBE
50.00
32%
-21
* C1 *
-
4FSN
2
CHK1_HUMAN
A:
[1-265]
------------------------------------------
A
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
-
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
---------------------
E
--------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
280
Blastp_CBE
49.99
33%
-24
- C1 -
-
2GHG
1
CHK1_HUMAN
A:
[14-266]
------------------------------------------------------
L
G
E
G
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
-
V
D
C
-------------
P
E
--------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
298
Blastp_CBE
49.72
33%
-14
- C1 -
-
2YEX
7
CHK1_HUMAN
A:
[15-267]
------------------------------------------------------
L
G
E
G
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
-
V
D
C
-------------
P
E
--------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
338
Blastp_CBE
49.46
33%
-13
- C1 -
-
1NVQ
1
CHK1_HUMAN
A:
[15-267]
------------------------------------------------------
L
G
E
G
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
-----------------------------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
314
Blastp_CBE
49.42
33%
-15
- C1 -
-
4HYI
4
CHK1_HUMAN
A:
[15-267]
------------------------------------------------------
L
G
E
G
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
------------------
P
E
--------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
316
Blastp_CBE
49.27
33%
-20
- C1 -
-
2YM8
10
CHK1_HUMAN
A:
[11-267]
------------------------------------------------------
L
G
E
-
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
--------------------------------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
293
Blastp_CBE
49.25
33%
-17
- C1 -
-
3OT3
1
CHK1_HUMAN
A:
[14-266]
------------------------------------------------------
L
G
E
G
A
-
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
---------------------
E
--------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
83
Blastp_CBE
49.17
33%
-19
- C1 -
-
5MAI
2
MELK_HUMAN
A:
[7-270]
-------------------------------------------
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
---
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
G
S
D
L
-------------
P
R
---------------
I
K
T
-------
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
---
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
---
E
L
F
D
Y
-
I
I
S
-
Q
-
D
-
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
---
Y
H
K
---
L
---
K
L
I
D
F
----------------------
S
L
A
Y
A
A
P
E
-
L
I
Q
G
-
K
S
Y
L
G
S
E
--
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
-
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
----
K
--
W
L
--
S
P
S
S
I
----
L
----
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
--
M
Q
--
D
Y
-------------------------------------------------------------------------------------------------------------------------
260
Blastp_CBE
49.07
33%
-16
- C1 -
-
2AYP
1
CHK1_HUMAN
A:
[15-267]
------------------------------------------------------
L
G
E
G
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
-
V
D
C
-------------
P
E
--------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
229
Blastp_CBE
49.06
31%
-29
- C1 -
-
4BDB
10
CHK2_HUMAN
A:
[17-285]
-----------------------------------------------
E
Y
I
M
S
K
T
L
------
E
V
K
---
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------------------------L---
N
V
E
T
-------
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
---
Y
Y
I
V
L
E
L
M
E
G
G
---
E
L
F
D
K
-
V
-
V
G
N
-
K
-
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
QEE
D
C
L
---
I
---
K
I
T
D
F
G
H
S
K
I
L
----
E
T
S
L
M
R
T
L
-
C
-
G
T
P
T
Y
L
A
P
E
-
V
L
V
S
V
G
T
-
A
G
Y
N
RA
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
----
P
--
E
V
--
W
A
E
V
S
EKAL
D
----
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
--
Q
------------------------------------------------------------------------------------------------------------------------------
270
Blastp_CBE
49.03
33%
-24
- C1 -
-
4FTJ
3
CHK1_HUMAN
A:
[14-266]
------------------------------------------------------
L
G
E
G
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
---------------------------------------
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
283
Blastp_CBE
49.01
33%
-13
- C1 -
-
2E9O
1
CHK1_HUMAN
A:
[14-266]
------------------------------------------------------
L
G
E
G
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
-
V
D
C
-------------
P
E
--------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
282
Blastp_CBE
48.99
33%
-9
- C1 -
-
2E9P
1
CHK1_HUMAN
A:
[14-266]
------------------------------------------------------
L
G
E
G
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
-
V
D
C
-------------
P
E
--------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
271
Blastp_CBE
48.95
33%
-21
- C1 -
-
4FTI
3
CHK1_HUMAN
A:
[14-266]
------------------------------------------------------
L
G
E
G
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
---------------------
E
--------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
93
Blastp_CBE
48.89
33%
-16
- C1 -
-
5TWZ
1
MELK_HUMAN
A:
[7-268]
-------------------------------------------
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
---
A
K
V
K
---
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
G
S
D
L
-------------
P
R
---------------
I
K
T
-------
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
---
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
---
E
L
F
D
Y
-
I
I
S
-
Q
-
D
-
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
---
Y
H
K
---
L
---
K
L
I
D
F
G
--------------------
G
S
L
A
Y
A
A
P
E
-
L
I
Q
G
-
K
S
Y
L
G
S
E
--
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
-
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
----
K
--
W
L
--
S
P
S
S
I
----
L
----
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
--
M
Q
--
D
Y
-------------------------------------------------------------------------------------------------------------------------
325
Blastp_CBE
48.86
33%
-17
- C1 -
-
2XEY
1
CHK1_HUMAN
A:
[11-267]
------------------------------------------------------
L
G
E
G
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
----------------------
E
--------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
317
Blastp_CBE
48.84
33%
-21
- C1 -
-
2YM7
5
CHK1_HUMAN
A:
[11-267]
------------------------------------------------------
L
G
E
-
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
--------------------------------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
337
Blastp_CBE
48.80
33%
-16
- C1 -
-
1NVR
1
CHK1_HUMAN
A:
[15-267]
------------------------------------------------------
L
G
E
G
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
-----------------------------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
273
Blastp_CBE
48.72
33%
-17
- C1 -
-
4FT7
4
CHK1_HUMAN
A:
[14-266]
------------------------------------------------------
L
G
E
G
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
------------------------------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
328
Blastp_CBE
48.57
33%
-23
- C1 -
-
2WMX
1
CHK1_HUMAN
A:
[11-267]
------------------------------------------------------
L
G
E
-
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
------------------------------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
212
Blastp_CBE
48.52
31%
-22
- C1 -
-
2YIR
1
CHK2_HUMAN
A:
[11-279]
-----------------------------------------------
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
---
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------------------------L---
N
V
E
T
-------
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
---
Y
Y
I
V
L
E
L
M
E
G
G
---
E
L
F
D
K
-
V
-
V
G
N
-
K
-
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
QEE
D
C
L
---
I
---
K
I
T
D
F
G
H
S
K
I
L
---
G
E
T
S
L
M
R
T
L
-
C
-
G
T
P
T
Y
L
A
P
E
-
V
L
V
S
V
G
T
-
A
G
Y
N
RA
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
----
P
--
E
V
--
W
A
E
V
S
EKAL
D
----
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
--
Q
------------------------------------------------------------------------------------------------------------------------------
288
Blastp_CBE
48.41
33%
-21
- C1 -
-
3U9N
1
CHK1_HUMAN
A:
[14-266]
------------------------------------------------------
L
G
E
G
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
----------------------
E
--------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
290
Blastp_CBE
48.35
33%
-15
- C1 -
-
3PA4
4
CHK1_HUMAN
A:
[14-266]
------------------------------------------------------
L
G
E
G
A
-
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
------------------------------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
315
Blastp_CBE
48.34
33%
-19
- C1 -
-
4HYH
1
CHK1_HUMAN
A:
[15-267]
------------------------------------------------------
L
G
E
G
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
-----------------------------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
264
Blastp_CBE
48.35
33%
-18
- C1 -
-
4FTT
4
CHK1_HUMAN
A:
[14-266]
------------------------------------------------------
L
G
E
---
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
-------------------------------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
72
Blastp_CBE
48.34
33%
-11
- C1 -
-
5IHC
1
MELK_HUMAN
A:
[5-266]
-------------------------------------------
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
---
A
K
V
K
---
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
G
S
D
L
-------------
P
R
---------------
I
K
T
-------
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
---
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
---
E
L
F
D
Y
-
I
I
S
-
Q
-
D
-
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
---
Y
H
K
---
L
---
K
L
I
D
F
---------------------
G
S
L
A
Y
A
A
P
E
-
L
I
Q
G
-
K
S
Y
L
G
S
E
--
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
-
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
----
K
--
W
L
--
S
P
S
S
I
----
L
----
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
--
M
Q
--
D
Y
-------------------------------------------------------------------------------------------------------------------------
278
Blastp_CBE
48.24
33%
-19
- C1 -
-
4FSM
3
CHK1_HUMAN
A:
[14-266]
------------------------------------------------------
L
G
E
---
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
--------------------------------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
263
Blastp_CBE
48.15
33%
-18
- C1 -
-
4FTU
4
CHK1_HUMAN
A:
[14-266]
------------------------------------------------------
L
G
E
G
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
------------------------------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
285
Blastp_CBE
48.12
33%
-16
- C1 -
-
5F4N
8
CHK1_HUMAN
A:
[15-267]
------------------------------------------------------
L
G
E
G
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
-------------------------------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
275
Blastp_CBE
48.01
33%
-17
- C1 -
-
4FT0
2
CHK1_HUMAN
A:
[14-270]
------------------------------------------------------
L
G
E
G
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
----------------------
E
--------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
332
Blastp_CBE
48.00
33%
-20
- C1 -
-
2WMT
1
CHK1_HUMAN
A:
[11-267]
------------------------------------------------------
L
G
E
-
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
------------------------------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
291
Blastp_CBE
47.88
33%
-18
- C1 -
-
3PA3
1
CHK1_HUMAN
A:
[14-266]
------------------------------------------------------
L
G
E
G
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
------------------------------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
336
Blastp_CBE
47.71
33%
-15
- C1 -
-
1NVS
1
CHK1_HUMAN
A:
[15-267]
------------------------------------------------------
L
G
E
G
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
-----------------------------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
334
Blastp_CBE
47.65
33%
-16
- C1 -
-
2WMR
1
CHK1_HUMAN
A:
[15-267]
------------------------------------------------------
L
G
E
G
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
------------------------------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
321
Blastp_CBE
47.65
33%
-19
- C1 -
-
2YM3
6
CHK1_HUMAN
A:
[11-267]
------------------------------------------------------
L
G
E
-
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
-------------------------------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
331
Blastp_CBE
47.60
33%
-21
- C1 -
-
2WMU
1
CHK1_HUMAN
A:
[11-267]
------------------------------------------------------
L
G
E
-
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
-------------------------------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
265
Blastp_CBE
47.47
33%
-19
- C1 -
-
4FTR
3
CHK1_HUMAN
A:
[14-266]
------------------------------------------------------
L
G
E
--
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
-----------------------
E
--------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
326
Blastp_CBE
47.43
33%
-12
- C1 -
-
2X8I
2
CHK1_HUMAN
A:
[15-267]
------------------------------------------------------
L
G
E
G
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
---------------------
E
--------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
277
Blastp_CBE
47.41
33%
-20
- C1 -
-
4FSQ
1
CHK1_HUMAN
A:
[10-266]
------------------------------------------------------
L
G
E
G
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
---------------------------------------
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
319
Blastp_CBE
47.40
33%
-17
- C1 -
-
2YM5
2
CHK1_HUMAN
A:
[11-267]
------------------------------------------------------
L
G
E
-
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
------------------------------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
330
Blastp_CBE
47.39
33%
-19
- C1 -
-
2WMV
1
CHK1_HUMAN
A:
[11-267]
------------------------------------------------------
L
G
E
-
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
------------------------------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
50
Blastp_CBE
47.37
36%
-2
- C1 -
-
6CMJ
6
KKCC2_HUMAN
B:
[33-304]
---------------------------------------------
L
D
Q
Y
T
L
K
D
E
I
G
K
G
S
Y
G
V
V
K
---
L
A
Y
N
E
N
D
N
T
Y
Y
A
M
K
V
L
S
K
K
K
L
-
I
R
Q
-------------
A
G
G
CIQPRGP
I
E
----
Q
V
Y
Q
-------
E
I
A
I
L
K
K
L
D
H
P
N
V
V
K
L
V
E
V
L
D
D
-
P
N
E
D
H
L
Y
M
V
F
E
L
V
N
Q
G
---
P
V
M
E
V
-
P
-
T
-
L
-
K
-
P
L
S
E
D
Q
A
R
F
Y
F
Q
D
L
I
K
G
I
E
Y
L
H
Y
Q
K
I
I
H
R
D
I
K
P
S
N
L
L
V
---
G
E
---
D
G
H
---
I
---
K
I
A
D
F
G
V
S
---
N
E
F
K
G
S
D
A
L
L
N
T
-
V
-
G
T
P
A
F
M
A
P
E
S
L
S
E
T
R
K
I
F
S
G
K
A
--
L
D
V
W
A
M
G
V
T
L
Y
C
F
V
F
G
Q
C
P
F
-
M
--
D
E
R
I
M
C
L
-
H
K
I
K
S
Q
A
L
E
F
P
----
D
QP
D
I
--
A
E
D
L
K
----
D
----
L
I
T
R
M
L
D
K
N
P
E
S
R
I
-----
V
V
P
E
I
K
L
H
P
W
V
--
T
R
-----------------------------------------------------------------------------------------------------------------------------
51
Blastp_CBE
47.33
36%
-2
- C1 -
-
6CMJ
5
KKCC2_HUMAN
A:
[33-304]
---------------------------------------------
L
D
Q
Y
T
L
K
D
E
I
G
K
G
S
Y
G
V
V
K
---
L
A
Y
N
E
N
D
N
T
Y
Y
A
M
K
V
L
S
K
K
K
L
-
I
R
Q
-------------
A
G
G
CIQPRGP
I
E
----
Q
V
Y
Q
-------
E
I
A
I
L
K
K
L
D
H
P
N
V
V
K
L
V
E
V
L
D
D
-
P
N
E
D
H
L
Y
M
V
F
E
L
V
N
Q
G
---
P
V
M
E
V
-
P
-
T
-
L
-
K
-
P
L
S
E
D
Q
A
R
F
Y
F
Q
D
L
I
K
G
I
E
Y
L
H
Y
Q
K
I
I
H
R
D
I
K
P
S
N
L
L
V
---
G
E
---
D
G
H
---
I
---
K
I
A
D
F
G
V
S
---
N
E
F
K
G
S
D
A
L
L
N
T
-
V
-
G
T
P
A
F
M
A
P
E
S
L
S
E
T
R
K
I
F
S
G
K
A
--
L
D
V
W
A
M
G
V
T
L
Y
C
F
V
F
G
Q
C
P
F
-
M
--
D
E
R
I
M
C
L
-
H
K
I
K
S
Q
A
L
E
F
P
----
D
QP
D
I
--
A
E
D
L
K
----
D
----
L
I
T
R
M
L
D
K
N
P
E
S
R
I
-----
V
V
P
E
I
K
L
H
P
W
V
--
T
R
-----------------------------------------------------------------------------------------------------------------------------
324
Blastp_CBE
47.27
33%
-18
- C1 -
-
2XEZ
7
CHK1_HUMAN
A:
[11-267]
------------------------------------------------------
L
G
E
-
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
------------------------------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
305
Blastp_CBE
47.18
32%
-5
- C1 -
-
2UZT
1
KAPCA_BOVIN
A:
[35-283]
------------------------------------------------------
L
G
T
G
S
F
G
R
V
M
---
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
-------------
K
Q
I
-------
E
H
----
T
L
N
E
-------
K
----
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
---
E
M
F
S
H
-
L
-
R
-
R
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
---
Q
G
Y
---
I
---
Q
V
T
D
F
G
F
A
K
R
V
-----
K
G
R
T
W
T
L
-
C
-
G
T
P
E
Y
L
A
P
E
-
I
I
--
L
S
K
G
Y
N
K
A
--
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
----
S
--
H
F
--
S
S
D
L
K
----
D
----
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
I
K
N
H
K
W
F
---------------------------------------------------------------------------------------------------------------------------------
202
Blastp_CBE
47.10
31%
13
- C1 -
-
3Q5I
1
?
A:
[28-309]
--------------------------------------
R
K
K
E
G
K
I
G
E
S
Y
F
K
V
R
K
L
G
S
--
Y
G
E
V
L
---
L
C
K
E
K
N
G
H
S
E
K
A
I
K
V
I
K
K
---------------------------------------
K
FHEEIYN
E
I
S
L
L
K
S
L
D
H
P
N
I
I
K
L
F
D
V
F
---
E
D
K
K
Y
F
Y
L
V
T
E
F
Y
E
G
G
---
E
L
F
E
Q
-
I
-
I
-
N
-
R
H
K
F
D
E
C
D
A
A
N
I
M
K
Q
I
L
S
G
I
C
Y
L
H
K
H
N
I
V
H
R
D
I
K
P
E
N
I
L
L
---
E
N
---
K
N
S
---
L
LNI
K
I
V
D
F
G
L
S
S
F
---
F
S
K
D
Y
K
L
R
D
R
-
L
-
G
T
A
Y
Y
I
A
P
E
-
V
---
L
K
K
K
Y
N
E
K
--
C
D
V
W
S
C
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
-
G
--
G
Q
N
D
Q
D
I
I
K
K
V
E
K
G
K
Y
Y
F
D
----
F
--
N
D
--
W
K
N
I
S
----
D
EAKE
L
I
K
L
M
L
T
Y
D
Y
N
K
R
C
-----
T
A
E
E
A
L
N
S
R
W
I
--
K
K
-----------------------------------------------------------------------------------------------------------------------------
300
Blastp_CBE
47.05
33%
-11
- C1 -
-
2YDK
5
CHK1_HUMAN
A:
[15-267]
------------------------------------------------------
L
G
E
G
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
-------------------
E
--------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
233
Blastp_CBE
47.03
31%
-4
- C1 -
-
4A9S
1
CHK2_HUMAN
A:
[17-285]
-----------------------------------------------
E
Y
I
M
S
K
T
L
------
E
V
K
---
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------------------------PAL-
N
V
E
T
-------
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
---
Y
Y
I
V
L
E
L
M
E
G
G
---
E
L
F
D
K
-
V
-
V
G
N
-
K
-
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
QEE
D
C
L
---
I
---
K
I
T
D
F
G
H
S
K
I
L
-----
T
S
L
M
R
T
L
-
C
-
G
T
P
T
Y
L
A
P
E
-
V
L
V
S
V
G
T
-
A
G
Y
N
RA
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
----
P
--
E
V
--
W
A
E
V
S
EKAL
D
----
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
--
Q
------------------------------------------------------------------------------------------------------------------------------
220
Blastp_CBE
47.01
31%
-6
- C1 -
-
4BDK
4
CHK2_HUMAN
A:
[17-285]
-----------------------------------------------
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
---
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------------------------AL--
N
V
E
T
-------
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
---
Y
Y
I
V
L
E
L
M
E
G
G
---
E
L
F
D
K
-
V
-
V
G
N
-
K
-
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
QEE
D
C
L
---
I
---
K
I
T
D
F
G
H
S
K
I
L
---
G
E
T
S
L
M
R
T
L
-
C
-
G
T
P
T
Y
L
A
P
E
-
V
L
V
S
V
G
T
-
A
G
Y
N
RA
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
----
P
--
E
V
--
W
A
E
V
S
EKAL
D
----
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
--
Q
------------------------------------------------------------------------------------------------------------------------------
302
Blastp_CBE
46.66
32%
-4
- C1 -
-
2UZW
1
KAPCA_BOVIN
E:
[35-283]
------------------------------------------------------
L
G
T
G
S
F
G
R
V
M
---
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
-------------
K
Q
I
-------
E
H
----
T
L
N
E
-------
K
----
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
---
E
M
F
S
H
-
L
-
R
-
R
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
---
Q
G
Y
---
I
---
Q
V
T
D
F
G
F
A
K
R
V
-----
K
G
R
T
W
T
L
-
C
-
G
T
P
E
Y
L
A
P
E
-
I
I
--
L
S
K
G
Y
N
K
A
--
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
----
S
--
H
F
--
S
S
D
L
K
----
D
----
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
I
K
N
H
K
W
F
---------------------------------------------------------------------------------------------------------------------------------
239
Blastp_CBE
46.57
31%
-4
- C1 -
-
2WTI
3
CHK2_HUMAN
A:
[17-285]
-----------------------------------------------
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
---
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------------------------PAL-
N
V
E
T
-------
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
---
Y
Y
I
V
L
E
L
M
E
G
G
---
E
L
F
D
K
-
V
-
V
G
N
-
K
-
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
QEE
D
C
L
---
I
---
K
I
T
D
F
G
H
S
K
I
L
----
E
T
S
L
M
R
T
L
-
C
-
G
T
P
T
Y
L
A
P
E
-
V
L
V
S
V
G
T
-
A
G
Y
N
RA
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
----
P
--
E
V
--
W
A
E
V
S
EKAL
D
----
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
--
Q
------------------------------------------------------------------------------------------------------------------------------
232
Blastp_CBE
46.54
31%
-2
- C1 -
-
4A9T
4
CHK2_HUMAN
A:
[17-285]
-----------------------------------------------
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
---
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------------------------PAL-
N
V
E
T
-------
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
---
Y
Y
I
V
L
E
L
M
E
G
G
---
E
L
F
D
K
-
V
-
V
G
N
-
K
-
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
QEE
D
C
L
---
I
---
K
I
T
D
F
G
H
S
K
I
L
---
G
E
T
S
L
M
R
T
L
-
C
-
G
T
P
T
Y
L
A
P
E
-
V
L
V
S
V
G
T
-
A
G
Y
N
RA
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
----
P
--
E
V
--
W
A
E
V
S
EKAL
D
----
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
--
Q
------------------------------------------------------------------------------------------------------------------------------
308
Blastp_CBE
46.53
32%
0
- C1 -
-
2F7Z
1
KAPCA_BOVIN
E:
[50-298]
------------------------------------------------------
L
G
T
G
S
F
G
R
V
M
---
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
-------------
K
Q
I
-------
E
H
----
T
L
N
E
-------
K
----
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
---
E
M
F
S
H
-
L
-
R
-
R
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
---
Q
G
Y
---
I
---
Q
V
T
D
F
G
F
A
K
R
V
-----
K
G
R
T
W
T
L
-
C
-
G
T
P
E
Y
L
A
P
E
-
I
I
--
L
S
K
G
Y
N
K
A
--
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
----
S
--
H
F
--
S
S
D
L
K
----
D
----
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
---------------------------------------------------------------------------------------------------------------------------------
266
Blastp_CBE
46.48
33%
-21
- C1 -
-
4FTO
4
CHK1_HUMAN
A:
[10-266]
------------------------------------------------------
L
G
E
G
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
-----------------------
E
--------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-----
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
318
Blastp_CBE
46.46
33%
-20
- C1 -
-
2YM6
6
CHK1_HUMAN
A:
[15-267]
------------------------------------------------------
L
G
E
G
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-------------------------------------
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
307
Blastp_CBE
46.34
32%
-1
- C1 -
-
2OH0
1
KAPCA_BOVIN
E:
[50-298]
------------------------------------------------------
L
G
T
G
S
F
G
R
V
M
---
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
-------------
K
Q
I
-------
E
H
----
T
L
N
E
-------
K
----
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
---
E
M
F
S
H
-
L
-
R
-
R
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
---
Q
G
Y
---
I
---
Q
V
T
D
F
G
F
A
K
R
V
-----
K
G
R
T
W
T
L
-
C
-
G
T
P
E
Y
L
A
P
E
-
I
I
--
L
S
K
G
Y
N
K
A
--
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
----
S
--
H
F
--
S
S
D
L
K
----
D
----
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
---------------------------------------------------------------------------------------------------------------------------------
309
Blastp_CBE
46.18
32%
-2
- C1 -
-
2F7X
1
KAPCA_BOVIN
E:
[50-298]
------------------------------------------------------
L
G
T
G
S
F
G
R
V
M
---
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
-------------
K
Q
I
-------
E
H
----
T
L
N
E
-------
K
----
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
---
E
M
F
S
H
-
L
-
R
-
R
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
---
Q
G
Y
---
I
---
Q
V
T
D
F
G
F
A
K
R
V
-----
K
G
R
T
W
T
L
-
C
-
G
T
P
E
Y
L
A
P
E
-
I
I
--
L
S
K
G
Y
N
K
A
--
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
----
S
--
H
F
--
S
S
D
L
K
----
D
----
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
---------------------------------------------------------------------------------------------------------------------------------
306
Blastp_CBE
46.18
32%
-3
- C1 -
-
2OJF
1
KAPCA_BOVIN
E:
[50-298]
------------------------------------------------------
L
G
T
G
S
F
G
R
V
M
---
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
-------------
K
Q
I
-------
E
H
----
T
L
N
E
-------
K
----
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
---
E
M
F
S
H
-
L
-
R
-
R
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
---
Q
G
Y
---
I
---
Q
V
T
D
F
G
F
A
K
R
V
-----
K
G
R
T
W
T
L
-
C
-
G
T
P
E
Y
L
A
P
E
-
I
I
--
L
S
K
G
Y
N
K
A
--
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
----
S
--
H
F
--
S
S
D
L
K
----
D
----
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
---------------------------------------------------------------------------------------------------------------------------------
235
Blastp_CBE
46.08
31%
-3
- C1 -
-
2XM9
1
CHK2_HUMAN
A:
[17-285]
-----------------------------------------------
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
---
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------------------------PAL-
N
V
E
T
-------
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
---
Y
Y
I
V
L
E
L
M
E
G
G
---
E
L
F
D
K
-
V
-
V
G
N
-
K
-
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
QEE
D
C
L
---
I
---
K
I
T
D
F
G
H
S
K
I
L
---
G
E
T
S
L
M
R
T
L
-
C
-
G
T
P
T
Y
L
A
P
E
-
V
L
V
S
V
G
T
-
A
G
Y
N
RA
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
----
P
--
E
V
--
W
A
E
V
S
EKAL
D
----
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
--
Q
------------------------------------------------------------------------------------------------------------------------------
333
Blastp_CBE
46.00
33%
-19
- C1 -
-
2WMS
1
CHK1_HUMAN
A:
[11-267]
------------------------------------------------------
L
G
E
-
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
---------------------------------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
------
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
310
Blastp_CBE
45.95
32%
0
- C1 -
-
2F7E
1
KAPCA_BOVIN
E:
[50-298]
------------------------------------------------------
L
G
T
G
S
F
G
R
V
M
---
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
-------------
K
Q
I
-------
E
H
----
T
L
N
E
-------
K
----
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
---
E
M
F
S
H
-
L
-
R
-
R
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
---
Q
G
Y
---
I
---
Q
V
T
D
F
G
F
A
K
R
V
-----
K
G
R
T
W
T
L
-
C
-
G
T
P
E
Y
L
A
P
E
-
I
I
--
L
S
K
G
Y
N
K
A
--
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
----
S
--
H
F
--
S
S
D
L
K
----
D
----
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
---------------------------------------------------------------------------------------------------------------------------------
226
Blastp_CBE
45.91
31%
-7
- C1 -
-
4BDE
5
CHK2_HUMAN
A:
[17-285]
-----------------------------------------------
E
Y
I
M
S
K
T
L
------
E
V
K
---
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------------------------AL--
N
V
E
T
-------
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
---
Y
Y
I
V
L
E
L
M
E
G
G
---
E
L
F
D
K
-
V
-
V
G
N
-
K
-
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
QEE
D
C
L
---
I
---
K
I
T
D
F
G
H
S
K
I
L
-----
T
S
L
M
R
T
L
-
C
-
G
T
P
T
Y
L
A
P
E
-
V
L
V
S
V
G
T
-
A
G
Y
N
RA
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
----
P
--
E
V
--
W
A
E
V
S
EKAL
D
----
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
--
Q
------------------------------------------------------------------------------------------------------------------------------
289
Blastp_CBE
45.82
33%
-16
- C1 -
-
3PA5
4
CHK1_HUMAN
A:
[14-266]
------------------------------------------------------
L
G
E
G
--
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
------------------------------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-----
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
303
Blastp_CBE
45.67
32%
2
- C1 -
-
2UZV
1
KAPCA_BOVIN
A:
[35-283]
------------------------------------------------------
L
G
T
G
S
F
G
R
V
M
---
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
-------------
K
Q
I
-------
E
H
----
T
L
N
E
-------
K
----
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
---
E
M
F
S
H
-
L
-
R
-
R
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
---
Q
G
Y
---
I
---
Q
V
T
D
F
G
F
A
K
R
V
-----
K
G
R
T
W
T
L
-
C
-
G
T
P
E
Y
L
A
P
E
-
I
I
--
L
S
K
G
Y
N
K
A
--
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
----
S
--
H
F
--
S
S
D
L
K
----
D
----
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
I
K
N
H
K
W
F
---------------------------------------------------------------------------------------------------------------------------------
249
Blastp_CBE
45.49
33%
-25
- C1 -
-
1CDK
2
KAPCA_PIG
B:
[49-297]
------------------------------------------------------
L
G
T
G
S
F
G
R
V
M
---
L
V
K
H
K
E
T
G
N
H
F
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
-------------
K
Q
I
-------
E
H
----
T
L
N
E
-------
K
----
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
Y
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
---
E
M
F
S
H
-
L
-
R
-
R
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
---
Q
G
Y
---
I
---
Q
V
T
D
F
G
-------
F
A
K
R
V
K
G
R
T
W
-
L
C
G
T
P
E
Y
L
A
P
E
-
I
I
--
L
S
K
G
Y
N
K
A
--
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
----
S
--
H
F
--
S
S
D
L
K
----
D
----
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
I
K
N
H
K
W
F
---------------------------------------------------------------------------------------------------------------------------------
335
Blastp_CBE
45.40
33%
-19
- C1 -
-
2WMQ
1
CHK1_HUMAN
A:
[15-267]
------------------------------------------------------
L
G
E
G
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
-------------------------------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
---------
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
329
Blastp_CBE
45.37
33%
-21
- C1 -
-
2WMW
1
CHK1_HUMAN
A:
[15-267]
------------------------------------------------------
L
G
------
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
------------------------------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
286
Blastp_CBE
45.26
32%
-32
- C1 -
-
3FHI
1
KAPCA_MOUSE
A:
[49-297]
------------------------------------------------------
L
G
T
G
S
F
G
R
V
M
---
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
-------------
K
Q
I
-------
E
H
----
T
L
N
E
-------
K
----
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
---
E
M
F
S
H
-
L
-
R
-
R
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
---
Q
G
Y
---
I
---
Q
V
T
D
F
G
-------
F
A
K
R
V
K
G
R
T
W
L
A
-
G
T
P
E
Y
L
A
P
E
-
I
I
--
L
S
K
G
Y
N
K
A
--
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
----
S
--
H
F
--
S
S
D
L
K
----
D
----
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
---------------------------------------------------------------------------------------------------------------------------------
234
Blastp_CBE
45.25
31%
-2
- C1 -
-
4A9R
2
CHK2_HUMAN
A:
[17-285]
-----------------------------------------------
E
Y
I
M
S
K
T
L
------
E
V
K
---
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------------------------PAL-
N
V
E
T
-------
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
---
Y
Y
I
V
L
E
L
M
E
G
G
---
E
L
F
D
K
-
V
-
V
G
N
-
K
-
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
QEE
D
C
L
---
I
---
K
I
T
D
F
G
H
S
K
I
L
---
G
E
T
S
L
M
R
T
L
-
C
-
G
T
P
T
Y
L
A
P
E
-
V
L
V
S
V
G
T
-
A
G
Y
N
RA
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
----
P
--
E
V
--
W
A
E
V
S
EKAL
D
----
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
--
Q
------------------------------------------------------------------------------------------------------------------------------
231
Blastp_CBE
45.22
31%
-6
- C1 -
-
4A9U
10
CHK2_HUMAN
A:
[17-285]
-----------------------------------------------
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
---
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------------------------DPAL
N
V
E
T
-------
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
---
Y
Y
I
V
L
E
L
M
E
G
G
---
E
L
F
D
K
-
V
-
V
G
N
-
K
-
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
QEE
D
C
L
---
I
---
K
I
T
D
F
G
H
S
K
I
L
-----
T
S
L
M
R
T
L
-
C
-
G
T
P
T
Y
L
A
P
E
-
V
L
V
S
V
G
T
-
A
G
Y
N
RA
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
----
P
--
E
V
--
W
A
E
V
S
EKAL
D
----
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
--
Q
------------------------------------------------------------------------------------------------------------------------------
250
Blastp_CBE
45.06
33%
-24
- C1 -
-
1CDK
2
KAPCA_PIG
A:
[49-297]
------------------------------------------------------
L
G
T
G
S
F
G
R
V
M
---
L
V
K
H
K
E
T
G
N
H
F
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
-------------
K
Q
I
-------
E
H
----
T
L
N
E
-------
K
----
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
Y
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
---
E
M
F
S
H
-
L
-
R
-
R
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
---
Q
G
Y
---
I
---
Q
V
T
D
F
G
-------
F
A
K
R
V
K
G
R
T
W
-
L
C
G
T
P
E
Y
L
A
P
E
-
I
I
--
L
S
K
G
Y
N
K
A
--
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
----
S
--
H
F
--
S
S
D
L
K
----
D
----
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
I
K
N
H
K
W
F
---------------------------------------------------------------------------------------------------------------------------------
240
Blastp_CBE
45.05
31%
-4
- C1 -
-
2WTD
4
CHK2_HUMAN
A:
[17-285]
-----------------------------------------------
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
---
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------------------------PAL-
N
V
E
T
-------
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
---
Y
Y
I
V
L
E
L
M
E
G
G
---
E
L
F
D
K
-
V
-
V
G
N
-
K
-
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
QEE
D
C
L
---
I
---
K
I
T
D
F
G
H
S
K
I
L
-----
T
S
L
M
R
T
L
-
C
-
G
T
P
T
Y
L
A
P
E
-
V
L
V
S
V
G
T
-
A
G
Y
N
RA
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
----
P
--
E
V
--
W
A
E
V
S
EKAL
D
----
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
--
Q
------------------------------------------------------------------------------------------------------------------------------
287
Blastp_CBE
45.02
33%
-11
- C1 -
-
4JIK
1
CHK1_HUMAN
A:
[14-266]
------------------------------------------------------
L
G
E
G
A
-
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
---------------------------------------
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
254
Blastp_CBE
44.94
33%
-24
- C1 -
-
4FTC
4
CHK1_HUMAN
A:
[10-266]
------------------------------------------------------
L
G
E
G
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
------------------------------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
-
Y
N
N
R
E
R
L
L
N
K
-
M
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
238
Blastp_CBE
44.77
31%
-1
- C1 -
-
2WTJ
5
CHK2_HUMAN
A:
[17-285]
-----------------------------------------------
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
---
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------------------------PAL-
N
V
E
T
-------
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
---
Y
Y
I
V
L
E
L
M
E
G
G
---
E
L
F
D
K
-
V
-
V
G
N
-
K
-
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
QEE
D
C
L
---
I
---
K
I
T
D
F
G
H
S
K
I
L
----
E
T
S
L
M
R
T
L
-
C
-
G
T
P
T
Y
L
A
P
E
-
V
L
V
S
V
G
T
-
A
G
Y
N
RA
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
----
P
--
E
V
--
W
A
E
V
S
EKAL
D
----
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
--
Q
------------------------------------------------------------------------------------------------------------------------------
320
Blastp_CBE
44.74
33%
-21
- C1 -
-
2YM4
4
CHK1_HUMAN
A:
[15-267]
------------------------------------------------------
L
G
E
G
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
--------------------------------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
-------
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
241
Blastp_CBE
44.53
31%
-10
- C1 -
-
2WTC
1
CHK2_HUMAN
A:
[17-285]
-----------------------------------------------
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
---
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------------------------PAL-
N
V
E
T
-------
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
---
Y
Y
I
V
L
E
L
M
E
G
G
---
E
L
F
D
K
-
V
-
V
G
N
-
K
-
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
QEE
D
C
L
---
I
---
K
I
T
D
F
G
H
S
K
I
L
-----
T
S
L
M
R
T
L
-
C
-
G
T
P
T
Y
L
A
P
E
-
V
L
V
S
V
G
T
-
A
G
Y
N
RA
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
----
P
--
E
V
--
W
A
E
V
S
EKAL
D
----
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
--
Q
------------------------------------------------------------------------------------------------------------------------------
312
Blastp_CBE
44.49
32%
-25
- C1 -
-
3L9M
1
KAPCA_HUMAN
B:
[50-298]
------------------------------------------------------
L
G
T
G
S
F
G
R
V
M
---
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
-------------
K
Q
I
-------
E
H
----
T
L
N
E
-------
K
----
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
---
E
M
F
S
H
-
L
-
R
-
R
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
---
D
Q
---
Q
G
Y
---
I
---
K
V
T
D
F
G
-------
F
A
K
R
V
K
G
R
T
W
-
L
C
G
T
P
E
Y
L
A
P
E
-
I
I
--
L
S
K
G
Y
N
K
A
--
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
----
S
--
H
F
--
S
S
D
L
K
----
D
----
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
---------------------------------------------------------------------------------------------------------------------------------
292
Blastp_CBE
44.35
33%
-18
- C1 -
-
3OT8
4
CHK1_HUMAN
A:
[14-266]
------------------------------------------------------
L
G
E
---
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
------------------------------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
------
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
-
C
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
257
Blastp_CBE
43.96
32%
-29
- C1 -
-
1YDT
1
KAPCA_BOVIN
E:
[49-297]
------------------------------------------------------
L
G
T
G
S
F
G
R
V
M
---
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
-------------
K
Q
I
-------
E
H
----
T
L
N
E
-------
K
----
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
---
E
M
F
S
H
-
L
-
R
-
R
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
---
Q
G
Y
---
I
---
Q
V
T
D
F
G
-------
F
A
K
R
V
K
G
R
T
W
-
L
C
G
T
P
E
Y
L
A
P
E
-
I
I
--
L
S
K
G
Y
N
K
A
--
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
----
S
--
H
F
--
S
S
D
L
K
----
D
----
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
I
K
N
H
K
W
F
---------------------------------------------------------------------------------------------------------------------------------
313
Blastp_CBE
43.90
32%
-31
- C1 -
-
3L9M
1
KAPCA_HUMAN
A:
[50-298]
------------------------------------------------------
L
G
T
G
S
F
G
R
V
M
---
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
-------------
K
Q
I
-------
E
H
----
T
L
N
E
-------
K
----
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
---
E
M
F
S
H
-
L
-
R
-
R
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
---
D
Q
---
Q
G
Y
---
I
---
K
V
T
D
F
G
-------
F
A
K
R
V
K
G
R
T
W
-
L
C
G
T
P
E
Y
L
A
P
E
-
I
I
--
L
S
K
G
Y
N
K
A
--
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
----
S
--
H
F
--
S
S
D
L
K
----
D
----
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
---------------------------------------------------------------------------------------------------------------------------------
256
Blastp_CBE
43.69
33%
-25
- C1 -
-
4FSW
2
CHK1_HUMAN
A:
[14-266]
------------------------------------------------------
L
G
E
G
--
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
--------------------------------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
-
Y
N
N
R
E
R
L
L
N
K
-
M
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
247
Blastp_CBE
43.69
33%
-26
- C1 -
-
4FST
5
CHK1_HUMAN
A:
[10-266]
------------------------------------------------------
L
G
E
G
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
--------------------------------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
-
Y
N
N
R
E
R
L
L
N
K
-
M
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
255
Blastp_CBE
43.58
33%
-24
- C1 -
-
4FTA
4
CHK1_HUMAN
A:
[14-266]
------------------------------------------------------
L
G
E
---
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
--------------------------------------
N
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
-
Y
N
N
R
E
R
L
L
N
K
-
M
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
311
Blastp_CBE
43.25
32%
-30
- C1 -
-
3L9N
1
KAPCA_HUMAN
A:
[50-301]
------------------------------------------------------
L
G
T
G
S
F
G
R
V
M
---
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
-------------
K
Q
I
-------
E
H
----
T
L
N
E
-------
K
----
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
---
E
M
F
S
H
-
L
-
R
-
R
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
---
D
Q
---
Q
G
Y
---
I
---
K
V
T
D
F
G
-------
F
A
K
R
V
K
G
R
T
W
-
L
C
G
T
P
E
Y
L
A
P
E
-
I
I
--
L
S
K
G
Y
N
K
A
--
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
----
S
--
H
F
--
S
S
D
L
K
----
D
----
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
---------------------------------------------------------------------------------------------------------------------------------
252
Blastp_CBE
42.21
33%
-25
- C1 -
-
4FTQ
3
CHK1_HUMAN
A:
[14-266]
------------------------------------------------------
L
G
E
G
--
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
---------------------------------------
I
K
K
-------
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
---
E
L
F
D
R
-
I
E
P
-
D
-
I
-
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
---
R
D
N
---
L
---
K
I
S
D
F
G
L
A
T
V
F
R
-
Y
N
N
R
E
R
L
L
N
K
-
M
-
G
T
L
P
Y
V
A
P
E
-
L
L
K
R
R
E
-
F
H
A
E
P
--
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
----
W
--
K
K
ID
S
A
P
L
A
---------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
--
N
K
-----------------------------------------------------------------------------------------------------------------------------
258
Blastp_CBE
41.97
32%
-31
- C1 -
-
1YDS
1
KAPCA_BOVIN
E:
[49-297]
------------------------------------------------------
L
G
T
G
S
F
G
R
V
M
---
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
-------------
K
Q
I
-------
E
H
----
T
L
N
E
-------
K
----
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
---
E
M
F
S
H
-
L
-
R
-
R
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
---
Q
G
Y
---
I
---
Q
V
T
D
F
G
-------
F
A
K
R
V
K
G
R
T
W
-
L
C
G
T
P
E
Y
L
A
P
E
-
I
I
--
L
S
K
G
Y
N
K
A
--
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
----
S
--
H
F
--
S
S
D
L
K
----
D
----
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
I
K
N
H
K
W
F
---------------------------------------------------------------------------------------------------------------------------------
246
Blastp_CBE
41.87
32%
-21
- C1 -
-
4WB6
1
KAPCA_HUMAN
B:
[49-297]
------------------------------------------------------
L
G
T
G
S
F
G
R
V
M
---
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
-------------
K
Q
I
-------
E
H
----
T
L
N
E
-------
K
----
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
---
E
M
F
S
H
-
L
-
R
-
R
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
---
Q
G
Y
---
I
---
Q
V
T
D
F
G
-------
F
A
K
R
V
K
G
R
T
W
-
L
C
G
T
P
E
Y
R
A
P
E
-
I
I
--
L
S
K
G
Y
N
K
A
--
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
----
S
--
H
F
--
S
S
D
L
K
----
D
----
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
---------------------------------------------------------------------------------------------------------------------------------
259
Blastp_CBE
41.70
32%
-29
- C1 -
-
1YDR
1
KAPCA_BOVIN
E:
[49-297]
------------------------------------------------------
L
G
T
G
S
F
G
R
V
M
---
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
-------------
K
Q
I
-------
E
H
----
T
L
N
E
-------
K
----
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
---
E
M
F
S
H
-
L
-
R
-
R
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
---
Q
G
Y
---
I
---
Q
V
T
D
F
G
-------
F
A
K
R
V
K
G
R
T
W
-
L
C
G
T
P
E
Y
L
A
P
E
-
I
I
--
L
S
K
G
Y
N
K
A
--
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
----
S
--
H
F
--
S
S
D
L
K
----
D
----
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
I
K
N
H
K
W
F
---------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
-
:
-----------------------------------------------------------------------------------------