@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : TEC_HUMAN: (2020-09-23 )
MNFNTILEEILIKRSQQKKKTSPLNYKERLFVLTKSMLTYYEGRAEKKYRKGFIDVSKIKCVEIVKNDDGVIPCQNKYPFQVVHDANTLYIFAPSPQSRDLWVKKLKEEIKNNNNIMIKYHPKFWTDGSYQCCRQTEKLAPGCEKYNLFESSIRKALPPAPETKKRRPPPPIPLEEEDNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARDKYGNEGYIPSNYVTGKKSNNLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDSSQPGLYTVSLYTKFGGEGSSGFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLRCWQEKPEGRPSFEDLLRTIDELVECEETFGR
Atome Classification :
(515 SA)
.........10........20........30........40....--.-...50........60........70...-----------.....80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.-.......220.-.......230.......240.......250......-.260.-.-......270...-.-...280.......290.....-..300.......310.......320.......330.......340.......350....------.-----.----------------------.----------------360.......370-------........380.......--390----.---.-.-.....400..--.---...--.410.......420.......430...-..-..440.......450....-.-.-.--460.-.-......470.......480.......490.......500.......510.....---..--520.....-...530.......540.......550.......560.......570........580.......590.......600.......610.......620.......630
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
N
F
N
T
I
L
E
E
I
L
I
K
R
S
Q
QKKKTSPL
N
Y
K
E
R
L
F
V
L
T
K
S
M
L
T
Y
Y
EG
R
A
--
E
-
K
K
Y
R
KGFIDVS
K
I
K
C
V
E
I
VKNDD
G
V
I
PC-----------QNKY
P
F
Q
V
V
HDA
N
T
L
Y
I
FAPSPQS
R
D
L
W
V
K
K
L
K
E
E
IKNNN
N
I
M
I
K
YHPKFWTDG
S
Y
Q
C
C
R
Q
T
E
KLAPG
C
E
K
Y
N
L
F
E
S
S
I
R
K
ALPPAPETKKRRPPPPIPLEEEDNSE
E
I
V
V
A
M
Y
D
FQAAEGHD
L
R
LERG
Q
E
Y
L
I
L
EK-N-D
V
H
W
W
R
ARD-K-YGNEGYIPSNYVTGKKSNN
L
D
Q
Y
E
W
Y
C
RNM
N
R
S
K
A
E
-
Q
L
L
-
R
-S-EDKEG
G
F
M
V
RDS-S-QP
G
L
Y
T
V
S
L
Y
T
KFGGEGSSG
F
-
R
H
Y
H
I
KETTTSP
K
K
Y
Y
L
A
EKHAFGS
I
P
E
I
I
E
Y
HKH
N
A
A
G
L
V
T
RLRY
P
V
S
VKGKNAPTTA------G-----
F
----------------------
S
----------------
Y
E
KWEI
N
P
S
E
L
T
--------
F
M
R
E
L
G
S
G
L
F
G
V
V
R
L
G
K
W
--
R
A
-----
Q
---
Y
-
K
-
V
A
I
K
A
I
REGA--M---
C
E
E
--
D
F
I
E
E
A
K
V
M
M
KLTH
P
K
L
V
Q
L
Y
G
VCTQQ-KP-
I
Y
I
V
T
E
F
M
ER
G
C
L
L
N
F
L
R
Q
-R-Q-G--H-F
S
-
R
-
D
V
L
L
S
M
C
Q
D
V
C
E
G
M
E
Y
L
E
RNS
F
I
H
R
D
L
A
A
RNCLVSEA
G
V
V
K
V
SDFG
M
A
R
Y
V
LDD---QY--TS-SSGAK-FPVKWC
P
P
E
VFNYSRFSSKS
D
V
W
S
F
G
V
L
M
W
E
V
F
TEGRM
P
F
E
KYT-N
Y
E
V
V
T
M
V
TRGHRLYQPKLA
S
N
Y
V
Y
E
V
M
L
R
C
W
QEKPEGRP
S
F
E
D
L
L
R
T
I
D
E
L
V
E
C
E
E
TFGR
540
HHSearch
91.24
60%
-128
- C2 -
-
4XI2
-
BTK_MOUSE
A:
[3-444]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
K
V
V
A
L
Y
D
Y
M
P
M
N
A
N
D
L
Q
L
R
K
G
E
E
Y
F
I
L
E
E
-
S
-
N
L
P
W
W
R
A
R
D
-
K
-
N
G
Q
E
G
Y
I
P
S
N
Y
I
T
E
A
-
E
D
S
I
E
M
Y
E
W
Y
S
K
H
M
T
R
S
Q
A
E
-
Q
L
L
--------
E
G
G
F
I
V
R
D
--------
Y
T
V
S
V
F
A
K
------
G
V
I
-
R
H
Y
V
V
C
--------
Y
Y
L
A
E
K
H
L
F
S
T
I
P
E
L
I
N
Y
H
Q
H
N
S
A
G
L
I
S
R
L
K
Y
P
V
S
K
Q
N
K
N
A
P
S
T
A
------
G
-----
L
----------------------
G
----------------
Y
G
S
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
R
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
R
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
S
F
K
I
L
L
S
N
I
L
D
V
M
D
E
------
1
PsiBlast_PDB
89.35
60%
-129
- C2 -
-
4XI2
-
BTK_MOUSE
A:
[6-444]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
A
L
Y
D
Y
M
P
M
N
A
N
D
L
Q
L
R
K
G
E
E
Y
F
I
L
E
E
-
S
-
N
L
P
W
W
R
A
R
D
-
K
-
N
G
Q
E
G
Y
I
P
S
N
Y
I
T
-
E
A
E
D
S
I
E
M
Y
E
W
Y
S
K
H
M
T
R
S
Q
A
E
-
Q
L
L
--------
E
G
G
F
I
V
R
D
--------
Y
T
V
S
V
F
A
K
------
G
V
I
-
R
H
Y
V
V
C
--------
Y
Y
L
A
E
K
H
L
F
S
T
I
P
E
L
I
N
Y
H
Q
H
N
S
A
G
L
I
S
R
L
K
Y
P
V
S
K
Q
N
K
N
A
P
S
T
A
------
G
-----
L
----------------------
G
----------------
Y
G
S
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
R
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
R
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
S
F
K
I
L
L
S
N
I
L
D
V
M
D
E
------
551
HHSearch
75.08
57%
9
- C2 -
-
4Y93
1
?
A:
[2-445]
-
M
A
T
V
I
L
E
S
I
F
L
K
R
S
--------
L
N
F
K
K
R
L
F
L
L
T
V
Q
K
L
S
Y
Y
E
Y
D
F
ER
G
R
R
G
S
K
K
G
S
I
D
V
E
K
I
T
C
V
E
T
V
V
P
E
K
N
P
P
P
E
RQIPEQISIIE
R
F
P
Y
P
F
Q
V
V
Y
D
E
G
P
L
Y
V
F
S
P
T
E
E
L
R
K
R
W
I
H
Q
L
K
N
V
I
R
Y
N
S
D
L
V
Q
K
Y
H
P
C
F
W
I
D
G
Q
Y
L
C
C
S
Q
T
A
K
N
A
M
G
C
Q
I
L
A
A
-------------------------------
A
-----------------------------------------------------
P
S
-------
T
--
A
-
G
L
G
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
T
G
S
K
-
F
P
V
K
W
A
S
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
P
R
P
H
L
A
S
E
R
V
Y
A
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
------
150
Blastp_CBE
73.20
40%
3
- C2 -
-
1OPK
3
ABL1_MOUSE
A:
[44-478]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
G
Y
-
N
H
N
G
E
W
C
E
A
Q
T
-
K
-
N
G
-
Q
G
W
V
P
S
N
Y
I
T
--
P
V
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
-
Y
L
L
---
S
-
S
G
I
N
G
S
F
L
V
R
E
S
E
S
-
S
P
G
Q
R
S
I
S
L
--
R
Y
E
G
-------
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
--
P
K
R
N
K
P
T
I
Y
------
G
-----
V
----------------------
S
PN--------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
154
Blastp_CBE
72.56
40%
5
- C2 -
-
1OPL
2
ABL1_HUMAN
A:
[81-517]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
G
Y
-
N
H
N
G
E
W
C
E
A
Q
T
-
K
-
N
G
-
Q
G
W
V
P
S
N
Y
I
T
--
P
V
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
-
Y
L
L
---
S
-
S
G
I
N
G
S
F
L
V
R
E
S
E
S
-
S
P
G
Q
R
S
I
S
L
--
R
Y
E
G
-------
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
--
K
R
N
K
P
T
V
Y
------
G
-----
V
----------------------
S
PN--------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
550
HHSearch
72.55
40%
-3
- C2 -
-
1OPK
3
ABL1_MOUSE
A:
[44-479]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
G
Y
-
N
H
N
G
E
W
C
E
A
Q
--
T
-
K
N
G
Q
G
W
V
P
S
N
Y
I
T
P
V
--
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
-
Y
L
L
-
S
---
S
G
I
N
G
S
F
L
V
R
E
S
-
E
S
S
P
G
Q
R
S
I
S
L
R
Y
------
E
G
R
V
-
Y
H
Y
R
I
N
T
A
--
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
K
R
N
K
P
T
I
Y
G
V
------
S
-----
P
----------------------
N
----------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
-
N
R
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
------
151
Blastp_CBE
72.32
40%
2
- C2 -
-
2FO0
4
ABL1_HUMAN
A:
[37-475]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
D
P
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
G
Y
-
N
H
N
G
E
W
C
E
A
Q
T
-
K
-
N
G
-
Q
G
W
V
P
S
N
Y
I
T
--
P
V
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
-
Y
L
L
---
S
-
S
G
I
N
G
S
F
L
V
R
E
S
E
S
-
S
P
G
Q
R
S
I
S
L
--
R
Y
E
G
-------
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
--
K
R
N
K
P
T
V
Y
------
G
-----
V
----------------------
S
PN--------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
548
HHSearch
71.57
39%
-2
- C2 -
-
2FO0
4
ABL1_HUMAN
A:
[38-476]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
D
P
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
G
Y
N
H
-
N
G
E
W
C
E
A
Q
T
---
K
N
G
Q
G
W
V
P
S
N
Y
I
T
P
V
--
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
-
Y
L
L
-
S
---
S
G
I
N
G
S
F
L
V
R
E
S
-
E
S
S
P
G
Q
R
S
I
S
L
R
Y
------
E
G
R
V
-
Y
H
Y
R
I
N
T
A
--
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
K
R
N
K
P
T
V
Y
G
V
------
S
-----
P
----------------------
N
----------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
-
N
R
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
------
49
Blastp_CBE
71.26
67%
-144
- C2 -
-
4HCT
1
A:
[4-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
V
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
R
E
G
A
--
M
---
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
---
Q
Y
--
T
S
-
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
-------
47
Blastp_CBE
71.19
67%
-147
- C2 -
-
4HCV
1
A:
[5-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
R
E
G
A
--
M
---
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
---
Q
Y
--
T
S
-
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
-------
48
Blastp_CBE
70.92
67%
-145
- C2 -
-
4HCU
1
A:
[5-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
R
E
G
A
--
M
---
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
---
Q
Y
--
T
S
-
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
-------
46
Blastp_CBE
70.52
67%
-142
- C2 -
-
4M0Y
2
A:
[5-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
R
E
G
A
--
M
---
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
---
Q
Y
--
T
S
-
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
-------
65
Blastp_CBE
70.27
62%
-145
- C2 -
-
4Y93
1
?
A:
[172-446]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
S
T
A
------
G
-----
L
----------------------
G
----------------
Y
G
S
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
T
G
S
K
-
F
P
V
K
W
A
S
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
P
R
P
H
L
A
S
E
R
V
Y
A
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
543
HHSearch
70.22
39%
8
- C2 -
-
1Y57
1
SRC_HUMAN
A:
[4-442]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
F
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
N
-
T
-
E
G
D
W
W
L
A
H
S
L
S
-
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
--
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
-
R
L
L
-
L
-
N
A
E
N
P
R
G
T
F
L
V
R
E
S
-
E
T
T
K
G
A
Y
C
L
S
V
S
D
F
D
N
A
-
K
G
L
N
V
-
K
H
Y
K
I
R
K
L
--
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
T
S
K
---
P
Q
T
Q
------
G
-----
L
----------------------
A
----------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
T
G
K
--
Y
-
L
R
-
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
--
T
A
-
R
Q
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
-----
43
Blastp_CBE
70.21
67%
-142
- C2 -
-
4M13
1
A:
[4-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
V
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
R
E
G
A
--
M
---
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
---
Q
Y
--
T
S
-
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
-------
56
Blastp_CBE
70.11
62%
-149
- C2 -
-
6DI5
2
A:
[1-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-----
L
----------------------
G
----------------
Y
G
S
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
42
Blastp_CBE
70.05
67%
-141
- C2 -
-
4M14
2
A:
[4-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
V
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
R
E
G
A
--
M
---
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
---
Q
Y
--
T
S
-
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
-------
33
Blastp_CBE
69.87
67%
-144
- C2 -
-
3T9T
3
A:
[3-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
R
E
G
A
--
M
---
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
T
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
---
Q
Y
--
T
S
-
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
-------
134
Blastp_CBE
69.79
62%
-147
- C2 -
-
5BPY
1
BTK_HUMAN
A:
[4-265]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
------
45
Blastp_CBE
69.75
67%
-143
- C2 -
-
4M0Z
2
A:
[4-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
V
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
R
E
G
A
--
M
---
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
---
Q
Y
--
T
S
-
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
-------
41
Blastp_CBE
69.72
67%
-142
- C2 -
-
4M15
2
A:
[4-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
V
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
R
E
G
A
--
M
---
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
---
Q
Y
--
T
S
-
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
-------
21
Blastp_CBE
69.71
62%
-135
- C2 -
-
4YHF
2
B:
[9-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----------------------
G
----------------
Y
G
S
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
545
HHSearch
69.68
38%
5
- C2 -
-
5H0B
1
HCK_HUMAN
A:
[8-446]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
E
-
S
-
G
-
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
--
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
-
R
Q
L
-
L
-
A
P
G
N
M
L
G
S
F
M
I
R
D
S
-
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
-
Q
G
D
T
V
-
K
H
Y
K
I
R
T
L
--
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
----
P
Q
K
------
P
-----
W
----------------------
E
----------------
K
D
A
W
E
I
P
R
E
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
K
-----
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
--
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
--
E
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
G
S
--
K
-
Q
P
-
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
---
E
Y
--
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
-----
541
HHSearch
69.66
38%
12
- C2 -
-
2H8H
1
SRC_HUMAN
A:
[87-525]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
F
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
N
-
T
-
E
G
D
W
W
L
A
H
S
-
L
S
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
--
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
-
R
L
L
-
L
-
N
A
E
N
P
R
G
T
F
L
V
R
E
S
-
E
T
T
K
G
A
Y
C
L
S
V
S
D
F
D
N
A
-
K
G
L
N
V
-
K
H
Y
K
I
R
K
L
--
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
T
S
K
---
P
Q
T
Q
------
G
-----
L
----------------------
A
----------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
T
G
K
--
Y
-
L
R
-
L
-
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
--
T
A
-
R
Q
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
-----
4
PsiBlast_PDB
69.62
62%
-149
- C2 -
-
5P9H
1
A:
[15-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
90
Blastp_CBE
69.47
63%
-145
- C2 -
-
6J6M
2
?
A:
[5-268]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
52
Blastp_CBE
69.45
62%
-143
- C2 -
-
6OMU
1
A:
[1-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-----
L
----------------------
G
----------------
Y
G
S
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
191
Blastp_CBE
69.42
38%
12
- C2 -
-
1QCF
1
HCK_HUMAN
A:
[10-448]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
E
-
S
-
G
-
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
--
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
N
M
L
G
S
F
M
I
R
D
S
E
T
-
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
-
V
-
K
H
Y
K
I
R
--
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------------
W
----------------------
E
----------------
K
D
A
W
E
I
P
R
E
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
K
-----
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
--
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
--
S
-
K
Q
P
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
---
E
Y
--
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
---
59
Blastp_CBE
69.42
62%
-141
- C2 -
-
6DI0
1
A:
[1-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-----
L
----------------------
G
----------------
Y
G
S
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
23
Blastp_CBE
69.36
62%
-143
- C2 -
-
6NZM
2
D:
[16-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
40
Blastp_CBE
69.34
62%
-137
- C2 -
-
6E4F
5
A:
[20-289]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-----
L
----------------------
G
----------------
Y
G
S
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
39
Blastp_CBE
69.34
62%
-141
- C2 -
-
3PIX
1
A:
[6-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
----------------
Y
G
S
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
44
Blastp_CBE
69.32
67%
-138
- C2 -
-
4M12
1
A:
[4-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
V
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
R
E
G
A
--
M
---
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
---
Q
Y
--
T
S
-
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
-------
156
Blastp_CBE
69.30
38%
8
- C2 -
-
5H0H
1
HCK_HUMAN
A:
[10-448]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
E
-
S
-
G
-
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
--
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
N
M
L
G
S
F
M
I
R
D
S
E
T
-
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
-
V
-
K
H
Y
K
I
R
--
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------------
W
----------------------
E
----------------
K
D
A
W
E
I
P
R
E
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
K
-----
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
--
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
--
S
-
K
Q
P
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
---
E
Y
--
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
---
58
Blastp_CBE
69.29
62%
-141
- C2 -
-
6DI1
1
A:
[1-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-----
L
----------------------
G
----------------
Y
G
S
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
7
PsiBlast_PDB
69.29
62%
-139
- C2 -
-
5P9K
1
A:
[9-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-----
L
----------------------
G
----------------
Y
G
S
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
26
Blastp_CBE
69.17
62%
-146
- C2 -
-
3GEN
1
A:
[16-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
---
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
54
Blastp_CBE
69.16
62%
-145
- C2 -
-
6N9P
1
A:
[1-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-----
L
----------------------
G
----------------
Y
G
S
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
61
Blastp_CBE
69.13
62%
-138
- C2 -
-
5U9D
6
A:
[1-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-----
L
----------------------
G
----------------
Y
G
S
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
53
Blastp_CBE
69.13
62%
-139
- C2 -
-
6NFH
7
A:
[1-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-----
L
----------------------
G
----------------
Y
G
S
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
93
Blastp_CBE
69.09
63%
-148
- C2 -
-
6S90
1
BTK_HUMAN
A:
[3-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
-------
60
Blastp_CBE
69.04
62%
-143
- C2 -
-
5VFI
9
A:
[1-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-----
L
----------------------
G
----------------
Y
G
S
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
24
Blastp_CBE
68.89
62%
-145
- C2 -
-
6NZM
1
BTK_HUMAN
A:
[16-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
----
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
6
PsiBlast_PDB
68.79
62%
-148
- C2 -
-
5P9J
1
A:
[14-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
----
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
5
PsiBlast_PDB
68.78
62%
-139
- C2 -
-
5P9I
3
A:
[9-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-----
L
----------------------
G
----------------
Y
G
S
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
31
Blastp_CBE
68.74
62%
-137
- C2 -
-
5J87
1
BTK_HUMAN
B:
[1-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
T
A
------
G
-----
L
----------------------
G
----------------
Y
G
S
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
9
PsiBlast_PDB
68.72
62%
-141
- C2 -
-
5P9M
2
A:
[9-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-----
L
----------------------
G
----------------
Y
G
S
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
51
Blastp_CBE
68.70
62%
-138
- C2 -
-
4ZLY
5
A:
[1-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-----
L
----------------------
G
----------------
Y
G
S
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
96
Blastp_CBE
68.67
63%
-144
- C2 -
-
5KUP
4
A:
[4-265]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
-------
186
Blastp_CBE
68.65
38%
-3
- C2 -
-
2C0T
1
HCK_HUMAN
A:
[10-448]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
E
-
S
-
G
-
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
--
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
N
M
L
G
S
F
M
I
R
D
S
E
T
-
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
-
V
-
K
H
Y
K
I
R
--------
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------------
W
----------------------
E
----------------
K
D
A
W
E
I
P
R
E
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
K
-----
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
--
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
--
S
-
K
Q
P
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
---
50
Blastp_CBE
68.63
62%
-138
- C2 -
-
4ZLZ
5
A:
[1-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-----
L
----------------------
G
----------------
Y
G
S
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
92
Blastp_CBE
68.57
63%
-144
- C2 -
-
6S90
1
B:
[3-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
-------
95
Blastp_CBE
68.56
63%
-145
- C2 -
-
5VGO
5
A:
[4-265]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
-------
157
Blastp_CBE
68.44
38%
8
- C2 -
-
5H0G
1
HCK_HUMAN
A:
[10-448]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
E
-
S
-
G
-
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
--
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
N
M
L
G
S
F
M
I
R
D
S
E
T
-
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
-
V
-
K
H
Y
K
I
R
--
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------------
W
----------------------
E
----------------
K
D
A
W
E
I
P
R
E
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
K
-----
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
--
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
--
S
-
K
Q
P
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
---
E
Y
--
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
---
172
Blastp_CBE
68.45
38%
-0
- C2 -
-
3VS4
1
HCK_HUMAN
A:
[10-448]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
E
-
S
-
G
-
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
--
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
N
M
L
G
S
F
M
I
R
D
S
E
T
-
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
-
V
-
K
H
Y
K
I
R
--------
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------------
W
----------------------
E
----------------
K
D
A
W
E
I
P
R
E
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
K
-----
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
--
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
--
S
-
K
Q
P
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
---
20
PsiBlast_PDB
68.44
62%
-138
- C2 -
-
4Z3V
5
A:
[13-282]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-----
L
----------------------
G
----------------
Y
G
S
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
11
PsiBlast_PDB
68.41
61%
-145
- C2 -
-
4OT6
1
A:
[18-282]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
A
-
R
-
H
--
A
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
553
HHSearch
68.32
38%
-42
- C2 -
-
3BKB
9
A:
[7-375]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
-
E
L
L
-
V
-----
H
S
G
D
F
L
V
R
E
S
-
Q
-
G
K
Q
E
Y
V
L
S
V
L
W
------
D
G
L
P
-
R
H
F
I
I
Q
S
L
---
D
N
-
L
Y
R
L
E
G
E
G
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
P
L
T
K
K
S
G
V
V
L
H
---------
R
------
A
-----
V
----------------------
P
----------------
K
D
K
W
V
L
N
H
E
D
L
V
--------
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
--
R
A
D----
N
---
T
-
L
-
V
A
V
K
S
C
R
E
T
L
PP
D
---
L
K
A
--
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
-
Q
P
-
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
-
E
-
G
-
A
--
R
-
L
R
-
V
-
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
---
V
Y
--
A
A
S
G
G
L
R
Q
-
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
-
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
------
158
Blastp_CBE
68.30
38%
8
- C2 -
-
5H0E
1
HCK_HUMAN
A:
[10-448]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
E
-
S
-
G
-
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
--
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
N
M
L
G
S
F
M
I
R
D
S
E
T
-
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
-
V
-
K
H
Y
K
I
R
--
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------------
W
----------------------
E
----------------
K
D
A
W
E
I
P
R
E
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
K
-----
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
--
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
--
S
-
K
Q
P
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
---
E
Y
--
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
---
132
Blastp_CBE
68.25
62%
-144
- C2 -
-
5JRS
2
BTK_HUMAN
A:
[4-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
----------
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
-------
130
Blastp_CBE
68.17
62%
-143
- C2 -
-
5T18
1
A:
[4-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
----------
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
97
Blastp_CBE
68.16
63%
-147
- C2 -
-
4RX5
4
A:
[4-265]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
-------
62
Blastp_CBE
68.10
62%
-154
- C2 -
-
5FBO
2
A:
[4-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
--------------------
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
25
Blastp_CBE
68.10
62%
-146
- C2 -
-
5BQ0
4
A:
[13-282]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-----
L
----------------------
G
----------------
Y
G
S
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---------
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
176
Blastp_CBE
68.08
38%
3
- C2 -
-
3VS2
1
HCK_HUMAN
A:
[10-448]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
E
-
S
-
G
-
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
--
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
N
M
L
G
S
F
M
I
R
D
S
E
T
-
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
-
V
-
K
H
Y
K
I
R
--
T
L
---
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------------
W
----------------------
E
----------------
K
D
A
W
E
I
P
R
E
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
K
-----
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
--
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
--
S
-
K
Q
P
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
---
81
Blastp_CBE
68.03
62%
-146
- C2 -
-
6O8I
1
A:
[2-268]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
---------------
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
552
HHSearch
67.87
38%
-44
- C2 -
-
6JMF
1
A:
[6-373]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
-
E
L
L
-
V
-----
H
S
G
D
F
L
V
R
E
S
-
Q
-
G
K
Q
E
Y
V
L
S
V
L
W
------
D
G
L
P
-
R
H
F
I
I
Q
S
L
---
D
N
-
L
Y
R
L
E
G
E
G
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
P
L
T
K
K
S
G
V
V
L
---------
H
R
------
A
-----
V
----------------------
P
----------------
K
D
K
W
V
L
N
H
E
D
L
V
--------
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
--
R
A
D----
N
---
T
-
L
-
V
A
V
K
S
C
R
E
T
L
PP
D
---
L
K
A
--
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
-
Q
P
-
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
-
E
-
G
-
A
--
R
-
L
R
-
V
-
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
---
V
Y
--
A
A
S
G
G
L
R
Q
-
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
-
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
------
91
Blastp_CBE
67.95
63%
-144
- C2 -
-
6AUB
1
A:
[1-262]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
-------
185
Blastp_CBE
67.90
38%
6
- C2 -
-
2C0T
1
HCK_HUMAN
B:
[10-448]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
E
-
S
-
G
-
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
--
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
N
M
L
G
S
F
M
I
R
D
S
E
T
-
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
-
V
-
K
H
Y
K
I
R
--
T
----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------------
W
----------------------
E
----------------
K
D
A
W
E
I
P
R
E
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
K
-----
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
--
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
--
S
-
K
Q
P
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
---
181
Blastp_CBE
67.90
38%
4
- C2 -
-
3VRZ
1
HCK_HUMAN
B:
[10-448]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
E
-
S
-
G
-
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
--
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
N
M
L
G
S
F
M
I
R
D
S
E
T
-
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
-
V
-
K
H
Y
K
I
R
--
T
----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------------
W
----------------------
E
----------------
K
D
A
W
E
I
P
R
E
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
K
-----
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
--
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
--
S
-
K
Q
P
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
-------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
---
168
Blastp_CBE
67.87
38%
2
- C2 -
-
3VS6
1
HCK_HUMAN
A:
[10-448]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
E
-
S
-
G
-
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
--
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
N
M
L
G
S
F
M
I
R
D
S
E
T
-
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
-
V
-
K
H
Y
K
I
R
--
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------------
W
----------------------
E
----------------
K
D
A
W
E
I
P
R
E
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
K
-----
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
--
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
--
S
-
K
Q
P
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
-------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
---
14
PsiBlast_PDB
67.88
61%
-147
- C2 -
-
4RFY
3
A:
[20-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
A
-
R
-
H
--
A
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
10
PsiBlast_PDB
67.87
61%
-143
- C2 -
-
4OT5
3
A:
[20-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
A
-
R
-
H
--
A
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
22
Blastp_CBE
67.86
62%
-138
- C2 -
-
4YHF
3
BTK_HUMAN
A:
[10-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
----------------
Y
G
S
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
159
Blastp_CBE
67.81
38%
7
- C2 -
-
5H0B
1
HCK_HUMAN
A:
[10-448]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
E
-
S
-
G
-
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
--
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
N
M
L
G
S
F
M
I
R
D
S
E
T
-
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
-
V
-
K
H
Y
K
I
R
--
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------------
W
----------------------
E
----------------
K
D
A
W
E
I
P
R
E
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
K
-----
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
--
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
--
S
-
K
Q
P
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
---
E
Y
--
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
---
27
Blastp_CBE
67.80
63%
-156
- C2 -
-
6MNY
1
?
A:
[12-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
R
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
----------------
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
A
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
R
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
S
F
K
I
L
L
S
N
I
L
D
V
M
D
-------
3
PsiBlast_PDB
67.79
62%
-143
- C2 -
-
5P9G
1
A:
[14-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
125
Blastp_CBE
67.78
62%
-144
- C2 -
-
6AUA
2
A:
[2-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
A
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
-------
29
Blastp_CBE
67.76
62%
-139
- C2 -
-
5J87
1
D:
[12-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
15
PsiBlast_PDB
67.69
61%
-143
- C2 -
-
4RFZ
3
A:
[20-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
A
-
R
-
H
--
A
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
2
PsiBlast_PDB
67.69
62%
-141
- C2 -
-
5P9F
6
A:
[14-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
544
HHSearch
67.67
38%
5
- C2 -
-
2HCK
1
HCK_HUMAN
B:
[2-431]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
E
---
S
G
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
--
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
-
R
Q
L
-
L
-
A
P
G
N
M
L
G
S
F
M
I
R
D
S
-
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
-
Q
G
D
T
V
-
K
H
Y
K
I
R
T
L
--
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
------
P
-----
W
----------------------
E
----------------
K
D
A
W
E
I
P
R
E
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
K
-----
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
--
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
--
E
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
G
S
--
K
-
Q
P
-
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
G
A
----------------
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
----
98
Blastp_CBE
67.65
63%
-157
- C2 -
-
3OCT
1
A:
[4-265]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
--
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
-----
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
---------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
-------
12
PsiBlast_PDB
67.65
61%
-143
- C2 -
-
4OTQ
3
A:
[20-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
A
-
R
-
H
--
A
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
143
Blastp_CBE
67.63
62%
-143
- C2 -
-
6BKE
1
A:
[4-265]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
-
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
-------
547
HHSearch
67.62
39%
-4
- C2 -
-
5MO4
2
ABL1_HUMAN
A:
[44-479]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
G
Y
-
N
H
N
G
E
W
C
E
A
Q
--
T
-
K
N
G
Q
G
W
V
P
S
N
Y
I
T
P
V
--
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
-
Y
L
L
-
S
---
S
G
I
N
G
S
F
L
V
R
E
S
-
E
S
S
P
G
Q
R
S
I
S
L
R
Y
------
E
G
R
V
-
Y
H
Y
R
I
N
T
A
--
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
K
R
N
K
P
T
V
Y
G
V
------
S
-----
P
----------------------
N
----------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
-------
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
-
N
R
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
-------------------------
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
------
160
Blastp_CBE
67.60
38%
10
- C2 -
-
5H09
1
HCK_HUMAN
A:
[10-448]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
E
-
S
-
G
-
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
--
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
N
M
L
G
S
F
M
I
R
D
S
E
T
-
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
-
V
-
K
H
Y
K
I
R
--
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------------
W
----------------------
E
----------------
K
D
A
W
E
I
P
R
E
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
K
-----
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
--
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
--
S
-
K
Q
P
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
---
E
Y
--
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
---
64
Blastp_CBE
67.58
62%
-149
- C2 -
-
5FBN
3
BTK_HUMAN
C:
[7-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
--------------
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
19
PsiBlast_PDB
67.53
61%
-142
- C2 -
-
6HRT
1
A:
[20-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
A
-
R
-
H
--
A
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
170
Blastp_CBE
67.52
38%
3
- C2 -
-
3VS5
1
HCK_HUMAN
A:
[10-448]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
E
-
S
-
G
-
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
--
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
N
M
L
G
S
F
M
I
R
D
S
E
T
-
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
-
V
-
K
H
Y
K
I
R
--
T
----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------------
W
----------------------
E
----------------
K
D
A
W
E
I
P
R
E
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
K
-----
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
--
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
--
S
-
K
Q
P
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
---
195
Blastp_CBE
67.44
40%
16
- C2 -
-
2H8H
1
SRC_HUMAN
A:
[89-514]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
N
-
T
-
E
G
D
W
W
L
A
H
S
L
S
-
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
--
P
S
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
-
R
L
L
L
N
-
A
-
E
N
P
R
G
T
F
L
V
R
E
S
E
T
-
T
K
G
A
Y
C
L
S
V
-
S
D
F
D
N
A
K
G
L
N
V
-
K
H
Y
K
I
R
K
L
D
S
G
--
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
---
T
T
V
C
P
T
S
K
P
Q
T
Q
------
G
-----
L
----------------------
A
----------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
T
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
--
T
A
-
R
Q
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
----------------
182
Blastp_CBE
67.44
38%
1
- C2 -
-
3VRZ
1
HCK_HUMAN
A:
[10-448]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
E
-
S
-
G
-
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
--
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
N
M
L
G
S
F
M
I
R
D
S
E
T
-
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
-
V
-
K
H
Y
K
I
R
--
T
----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------------
W
----------------------
E
----------------
K
D
A
W
E
I
P
R
E
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
K
-----
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
--
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
--
S
-
K
Q
P
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
---
17
PsiBlast_PDB
67.43
61%
-145
- C2 -
-
6EP9
1
A:
[20-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
A
-
R
-
H
--
A
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
144
Blastp_CBE
67.42
62%
-141
- C2 -
-
6BIK
2
A:
[4-265]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
-
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
-------
141
Blastp_CBE
67.41
62%
-143
- C2 -
-
6BKW
4
A:
[4-265]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
-
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
-------
74
Blastp_CBE
67.40
67%
-153
- C2 -
-
3V5L
1
D:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
-
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
R
--
A
--
M
---
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
-----------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
-------
193
Blastp_CBE
67.34
40%
13
- C2 -
-
1Y57
1
SRC_HUMAN
A:
[6-431]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
N
-
T
-
E
G
D
W
W
L
A
H
S
L
S
-
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
--
P
S
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
-
R
L
L
L
N
-
A
-
E
N
P
R
G
T
F
L
V
R
E
S
E
T
-
T
K
G
A
Y
C
L
S
V
-
S
D
F
D
N
A
K
G
L
N
V
-
K
H
Y
K
I
R
K
L
D
S
G
--
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
---
T
T
V
C
P
T
S
K
P
Q
T
Q
------
G
-----
L
----------------------
A
----------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
T
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
--
T
A
-
R
Q
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
----------------
30
Blastp_CBE
67.34
62%
-138
- C2 -
-
5J87
1
BTK_HUMAN
C:
[12-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
-------
183
Blastp_CBE
67.33
38%
7
- C2 -
-
3VRY
1
HCK_HUMAN
B:
[10-448]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
E
-
S
-
G
-
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
--
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
N
M
L
G
S
F
M
I
R
D
S
E
T
-
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
-
V
-
K
H
Y
K
I
R
--
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------------
W
----------------------
E
----------------
K
D
A
W
E
I
P
R
E
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
K
-----
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
--
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
--
S
-
K
Q
P
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
-------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
---
194
Blastp_CBE
67.32
40%
11
- C2 -
-
6F3F
1
SRC_MOUSE
A:
[9-434]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
N
-
T
-
E
G
D
W
W
L
A
H
S
L
S
-
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
--
P
S
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
-
R
L
L
L
N
-
A
-
E
N
P
R
G
T
F
L
V
R
E
S
E
T
-
T
K
G
A
Y
C
L
S
V
-
S
D
F
D
N
A
K
G
L
N
V
-
K
H
Y
K
I
R
K
L
D
S
G
--
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
---
T
T
V
C
P
T
S
K
P
Q
T
Q
------
G
-----
L
----------------------
A
----------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
G
-
E
-
T
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
--
T
A
-
R
Q
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
----------------
173
Blastp_CBE
67.31
38%
-0
- C2 -
-
3VS3
1
HCK_HUMAN
B:
[10-448]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
E
-
S
-
G
-
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
--
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
N
M
L
G
S
F
M
I
R
D
S
E
T
-
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
-
V
-
K
H
Y
K
I
R
--
T
-----
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------------
W
----------------------
E
----------------
K
D
A
W
E
I
P
R
E
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
K
-----
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
--
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
--
S
-
K
Q
P
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
----------------
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
---
94
Blastp_CBE
67.30
62%
-141
- C2 -
-
3OCS
2
A:
[4-267]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
-
E
N
----
174
Blastp_CBE
67.26
38%
0
- C2 -
-
3VS3
1
HCK_HUMAN
A:
[10-448]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
E
-
S
-
G
-
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
--
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
N
M
L
G
S
F
M
I
R
D
S
E
T
-
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
-
V
-
K
H
Y
K
I
R
--
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------------
W
----------------------
E
----------------
K
D
A
W
E
I
P
R
E
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
K
-----
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
--
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
--
S
-
K
Q
P
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
-------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
---
140
Blastp_CBE
67.22
62%
-142
- C2 -
-
6BLN
2
A:
[4-265]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
-
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
-------
16
PsiBlast_PDB
67.21
61%
-144
- C2 -
-
4RG0
1
A:
[20-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
A
-
R
-
H
--
A
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
196
Blastp_CBE
67.19
40%
11
- C2 -
-
4K11
1
SRC_HUMAN
A:
[4-429]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
N
-
T
-
E
G
D
W
W
L
A
H
S
L
S
-
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
--
P
S
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
-
R
L
L
L
N
-
A
-
E
N
P
R
G
T
F
L
V
R
E
S
E
T
-
T
K
G
A
Y
C
L
S
V
-
S
D
F
D
N
A
K
G
L
N
V
-
K
H
Y
K
I
R
K
L
D
S
G
--
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
---
T
T
V
C
P
T
S
K
P
Q
T
Q
------
G
-----
L
----------------------
A
----------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
T
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
--
T
A
-
R
Q
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
----------------
192
Blastp_CBE
67.18
40%
12
- C2 -
-
2SRC
1
SRC_HUMAN
A:
[6-431]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
N
-
T
-
E
G
D
W
W
L
A
H
S
L
S
-
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
--
P
S
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
-
R
L
L
L
N
-
A
-
E
N
P
R
G
T
F
L
V
R
E
S
E
T
-
T
K
G
A
Y
C
L
S
V
-
S
D
F
D
N
A
K
G
L
N
V
-
K
H
Y
K
I
R
K
L
D
S
G
--
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
---
T
T
V
C
P
T
S
K
P
Q
T
Q
------
G
-----
L
----------------------
A
----------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
T
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
--
T
A
-
R
Q
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
----------------
129
Blastp_CBE
67.14
65%
-149
- C2 -
-
3QGW
1
ITK_HUMAN
A:
[24-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
K
E
G
S
--
M
---
S
E
D
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
-------
86
Blastp_CBE
67.14
67%
-139
- C2 -
-
3MJ2
1
A:
[4-258]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
R
E
G
A
--
M
---
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
---
Q
Y
--
T
S
-
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
------------
57
Blastp_CBE
67.14
62%
-147
- C2 -
-
6DI3
1
A:
[5-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
--
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
---------------
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
179
Blastp_CBE
67.13
38%
6
- C2 -
-
3VS0
1
HCK_HUMAN
B:
[10-448]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
E
-
S
-
G
-
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
--
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
N
M
L
G
S
F
M
I
R
D
S
E
T
-
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
-
V
-
K
H
Y
K
I
R
--
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------------
W
----------------------
E
----------------
K
D
A
W
E
I
P
R
E
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
K
-----
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
--
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
--
S
-
K
Q
P
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
---
18
PsiBlast_PDB
67.08
61%
-143
- C2 -
-
6HRP
1
A:
[20-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
A
-
R
-
H
--
A
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
187
Blastp_CBE
67.06
38%
6
- C2 -
-
2C0O
1
HCK_HUMAN
B:
[10-448]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
E
-
S
-
G
-
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
--
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
N
M
L
G
S
F
M
I
R
D
S
E
T
-
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
-
V
-
K
H
Y
K
I
R
--
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------------
W
----------------------
E
----------------
K
D
A
W
E
I
P
R
E
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
K
-----
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
--
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
--
S
-
K
Q
P
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
---
35
Blastp_CBE
67.02
62%
-155
- C2 -
-
3PJ2
1
A:
[6-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
----------------
Y
G
S
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
---
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
-------------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
198
Blastp_CBE
67.01
37%
5
- C2 -
-
2HCK
1
HCK_HUMAN
B:
[4-432]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
E
-
S
-
G
-
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
--
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
N
M
L
G
S
F
M
I
R
D
S
E
T
-
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
-
V
-
K
H
Y
K
I
R
--
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------------
W
----------------------
E
----------------
K
D
A
W
E
I
P
R
E
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
K
-----
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
--
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
--
S
-
K
Q
P
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
----------------
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
---
70
Blastp_CBE
67.00
67%
-155
- C2 -
-
3V8W
1
B:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
R
-----
M
---
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
-------
155
Blastp_CBE
66.99
40%
3
- C2 -
-
5MO4
2
ABL1_HUMAN
A:
[44-478]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
G
Y
-
N
H
N
G
E
W
C
E
A
Q
T
-
K
-
N
G
-
Q
G
W
V
P
S
N
Y
I
T
--
P
V
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
-
Y
L
L
---
S
-
S
G
I
N
G
S
F
L
V
R
E
S
E
S
-
S
P
G
Q
R
S
I
S
L
--
R
Y
E
G
-------
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
--
P
K
R
N
K
P
T
V
Y
------
G
-----
V
----------------------
S
PN--------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
-------
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
-------------------------
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
122
Blastp_CBE
66.96
66%
-150
- C2 -
-
4KIO
3
ITK_HUMAN
C:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
R
E
G
A
--
M
---
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
----------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
-------
180
Blastp_CBE
66.97
38%
2
- C2 -
-
3VS0
1
HCK_HUMAN
A:
[10-448]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
E
-
S
-
G
-
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
--
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
N
M
L
G
S
F
M
I
R
D
S
E
T
-
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
-
V
-
K
H
Y
K
I
R
-------
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------------
W
----------------------
E
----------------
K
D
A
W
E
I
P
R
E
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
K
-----
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
--
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
--
S
-
K
Q
P
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
---
55
Blastp_CBE
66.96
62%
-154
- C2 -
-
6DI9
2
A:
[4-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
------
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
----------------
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
8
PsiBlast_PDB
66.92
62%
-153
- C2 -
-
5P9L
1
A:
[12-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
----
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
----------------
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
------
188
Blastp_CBE
66.90
38%
4
- C2 -
-
2C0O
1
HCK_HUMAN
A:
[10-448]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
E
-
S
-
G
-
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
--
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
N
M
L
G
S
F
M
I
R
D
S
E
T
-
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
-
V
-
K
H
Y
K
I
R
--
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------------
W
----------------------
E
----------------
K
D
A
W
E
I
P
R
E
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
K
-----
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
--
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
--
S
-
K
Q
P
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
---
167
Blastp_CBE
66.88
38%
3
- C2 -
-
3VS6
1
HCK_HUMAN
B:
[10-448]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
E
-
S
-
G
-
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
--
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
N
M
L
G
S
F
M
I
R
D
S
E
T
-
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
-
V
-
K
H
Y
K
I
R
--
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------------
W
----------------------
E
----------------
K
D
A
W
E
I
P
R
E
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
K
-----
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
--
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
--
S
-
K
Q
P
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
-------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
---
171
Blastp_CBE
66.87
38%
2
- C2 -
-
3VS4
1
HCK_HUMAN
B:
[10-448]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
E
-
S
-
G
-
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
--
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
N
M
L
G
S
F
M
I
R
D
S
E
T
-
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
-
V
-
K
H
Y
K
I
R
--
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------------
W
----------------------
E
----------------
K
D
A
W
E
I
P
R
E
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
K
-----
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
--
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
--
S
-
K
Q
P
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
-------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
---
75
Blastp_CBE
66.84
67%
-151
- C2 -
-
3V5L
1
ITK_HUMAN
C:
[4-262]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
---
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
R
E
G
A
--
M
---
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
----------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
--------
78
Blastp_CBE
66.83
67%
-161
- C2 -
-
3V5J
1
B:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
------
M
---
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
--------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
-------
190
Blastp_CBE
66.73
38%
4
- C2 -
-
2C0I
1
HCK_HUMAN
A:
[10-448]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
E
-
S
-
G
-
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
--
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
N
M
L
G
S
F
M
I
R
D
S
E
T
-
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
-
V
-
K
H
Y
K
I
R
--
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------------
W
----------------------
E
----------------
K
D
A
W
E
I
P
R
E
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
K
-----
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
--
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
--
S
-
K
Q
P
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
---
184
Blastp_CBE
66.73
38%
2
- C2 -
-
3VRY
1
HCK_HUMAN
A:
[10-448]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
E
-
S
-
G
-
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
--
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
N
M
L
G
S
F
M
I
R
D
S
E
T
-
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
-
V
-
K
H
Y
K
I
R
--------
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------------
W
----------------------
E
----------------
K
D
A
W
E
I
P
R
E
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
K
-----
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
--
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
--
S
-
K
Q
P
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
-------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
---
119
Blastp_CBE
66.67
66%
-146
- C2 -
-
4L7S
1
B:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
R
E
G
A
--
M
---
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
-------
63
Blastp_CBE
66.67
62%
-147
- C2 -
-
5FBN
5
D:
[6-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
-----------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
199
Blastp_CBE
66.65
37%
9
- C2 -
-
2HCK
1
HCK_HUMAN
A:
[4-432]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
E
-
S
-
G
-
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
--
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
N
M
L
G
S
F
M
I
R
D
S
E
T
-
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
-
V
-
K
H
Y
K
I
R
--
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------------
W
----------------------
E
----------------
K
D
A
W
E
I
P
R
E
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
K
-----
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
--
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
--
S
-
K
Q
P
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
----------------
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
---
32
Blastp_CBE
66.63
62%
-141
- C2 -
-
5J87
1
BTK_HUMAN
A:
[12-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
147
Blastp_CBE
66.58
61%
-132
- C2 -
-
3SXS
1
A:
[4-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
K
R
E
E
I
T
--------
L
L
K
E
L
G
S
G
Q
F
G
V
V
K
L
G
K
W
--
K
G
-----
Q
---
Y
-
D
-
V
A
V
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
F
Q
E
A
Q
T
M
M
K
L
S
H
P
K
L
V
K
F
Y
G
V
C
S
K
E
-
Y
P
-
I
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
S
-
H
-
G
-
K
--
G
-
L
E
-
P
-
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
D
R
D
L
C
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
D
---
Q
Y
--
V
S
-
S
V
G
T
K
-
F
P
V
K
W
S
A
P
E
V
F
H
Y
F
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
T
-
N
S
E
V
V
L
K
V
S
Q
G
H
R
L
Y
R
P
H
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
E
P
L
R
E
-------
120
Blastp_CBE
66.57
66%
-145
- C2 -
-
4L7S
1
ITK_HUMAN
A:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
R
E
G
A
--
M
---
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
-------
13
PsiBlast_PDB
66.55
61%
-144
- C2 -
-
4OTR
3
A:
[20-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
A
-
R
-
H
--
A
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
201
Blastp_CBE
66.52
37%
10
- C2 -
-
1AD5
1
HCK_HUMAN
A:
[4-432]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
E
-
S
-
G
-
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
--
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
N
M
L
G
S
F
M
I
R
D
S
E
T
-
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
-
V
-
K
H
Y
K
I
R
--
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------------
W
----------------------
E
----------------
K
D
A
W
E
I
P
R
E
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
K
-----
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
--
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
--
S
-
K
Q
P
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
----------------
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
---
68
Blastp_CBE
66.42
67%
-152
- C2 -
-
1SM2
1
B:
[2-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
R
E
G
A
--
M
---
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
--------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
-------
189
Blastp_CBE
66.38
38%
8
- C2 -
-
2C0I
1
HCK_HUMAN
B:
[10-448]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
E
-
S
-
G
-
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
--
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
N
M
L
G
S
F
M
I
R
D
S
E
T
-
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
-
V
-
K
H
Y
K
I
R
--
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------------
W
----------------------
E
----------------
K
D
A
W
E
I
P
R
E
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
K
-----
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
--
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
--
S
-
K
Q
P
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
---
165
Blastp_CBE
66.34
38%
7
- C2 -
-
3VS7
1
HCK_HUMAN
B:
[10-448]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
E
-
S
-
G
-
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
--
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
N
M
L
G
S
F
M
I
R
D
S
E
T
-
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
-
V
-
K
H
Y
K
I
R
--
T
-----
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------------
W
----------------------
E
----------------
K
D
A
W
E
I
P
R
E
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
K
-----
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
--
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
--
S
-
K
Q
P
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
---
178
Blastp_CBE
66.31
38%
6
- C2 -
-
3VS1
1
HCK_HUMAN
A:
[10-448]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
E
-
S
-
G
-
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
--
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
N
M
L
G
S
F
M
I
R
D
S
E
T
-
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
-
V
-
K
H
Y
K
I
R
-----------
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------------
W
----------------------
E
----------------
K
D
A
W
E
I
P
R
E
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
K
-----
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
--
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
--
S
-
K
Q
P
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
---
142
Blastp_CBE
66.28
62%
-141
- C2 -
-
6BKH
1
A:
[5-265]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
-
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
-------
169
Blastp_CBE
66.18
38%
5
- C2 -
-
3VS5
1
HCK_HUMAN
B:
[10-448]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
E
-
S
-
G
-
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
--
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
N
M
L
G
S
F
M
I
R
D
S
E
T
-
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
-
V
-
K
H
Y
K
I
R
--------
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------------
W
----------------------
E
----------------
K
D
A
W
E
I
P
R
E
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
K
-----
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
--
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
--
S
-
K
Q
P
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
---
115
Blastp_CBE
66.00
66%
-150
- C2 -
-
4PP9
1
B:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
R
E
G
A
--
M
---
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
-------
200
Blastp_CBE
65.99
37%
13
- C2 -
-
1AD5
1
HCK_HUMAN
B:
[4-432]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
E
-
S
-
G
-
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
--
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
N
M
L
G
S
F
M
I
R
D
S
E
T
-
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
-
V
-
K
H
Y
K
I
R
--
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------------
W
----------------------
E
----------------
K
D
A
W
E
I
P
R
E
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
K
-----
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
--
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
--
S
-
K
Q
P
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
----------------
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
---
124
Blastp_CBE
65.97
66%
-153
- C2 -
-
4KIO
2
ITK_HUMAN
A:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
---
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
-----------
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
-------
197
Blastp_CBE
65.93
40%
13
- C2 -
-
1KSW
1
SRC_HUMAN
A:
[6-431]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
N
-
T
-
E
G
D
W
W
L
A
H
S
L
S
-
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
--
P
S
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
-
R
L
L
L
N
-
A
-
E
N
P
R
G
T
F
L
V
R
E
S
E
T
-
T
K
G
A
Y
C
L
S
V
-
S
D
F
D
N
A
K
G
L
N
V
-
K
H
Y
K
I
R
K
L
D
S
G
--
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
---
T
T
V
C
P
T
S
K
P
Q
T
Q
------
G
-----
L
----------------------
A
----------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
T
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
--
T
A
-
R
Q
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
----------------
66
Blastp_CBE
65.90
67%
-151
- C2 -
-
1SNU
1
B:
[2-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
R
E
G
A
--
M
---
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
--------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
-------
133
Blastp_CBE
65.84
62%
-159
- C2 -
-
5BPY
1
B:
[4-265]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
-
G
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
------
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
-----------------
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
------
162
Blastp_CBE
65.82
38%
5
- C2 -
-
4LUE
3
HCK_HUMAN
A:
[10-448]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
E
-
S
-
G
-
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
--
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
N
M
L
G
S
F
M
I
R
D
S
E
T
-
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
-
V
-
K
H
Y
K
I
R
--
T
----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------------
W
----------------------
E
----------------
K
D
A
W
E
I
P
R
E
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
K
-----
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
-------------
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
--
S
-
K
Q
P
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
---
72
Blastp_CBE
65.76
67%
-149
- C2 -
-
3V8T
1
B:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
---
A
--
M
---
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
-------
164
Blastp_CBE
65.71
38%
5
- C2 -
-
4LUD
2
HCK_HUMAN
A:
[10-448]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
E
-
S
-
G
-
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
--
R
---
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
N
M
L
G
S
F
M
I
R
D
S
E
T
-
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
-
V
-
K
H
Y
K
I
R
--
T
L
D
--
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------------
W
----------------------
E
----------------
K
D
A
W
E
I
P
R
E
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
K
-----
H
---
T
-
K
-
V
A
V
K
T
M
K
P
--------
S
V
E
--
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
--
S
-
K
Q
P
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
----
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
---
116
Blastp_CBE
65.70
66%
-148
- C2 -
-
4PP9
1
ITK_HUMAN
A:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
R
E
G
A
--
M
---
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
-------
71
Blastp_CBE
65.70
67%
-153
- C2 -
-
3V8W
1
ITK_HUMAN
A:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
R
-
G
A
--
M
---
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
-
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
-------
127
Blastp_CBE
65.65
65%
-142
- C2 -
-
3QGY
1
ITK_HUMAN
A:
[24-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
K
E
G
S
--
M
---
S
E
D
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
-------
37
Blastp_CBE
65.65
62%
-151
- C2 -
-
3PIZ
1
A:
[6-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
----------------
Y
G
S
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
---
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
----------
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-----------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
161
Blastp_CBE
65.59
38%
3
- C2 -
-
4LUE
4
HCK_HUMAN
B:
[10-448]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
E
-
S
-
G
-
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
--
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
N
M
L
G
S
F
M
I
R
D
S
E
T
-
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
-
V
-
K
H
Y
K
I
R
--
T
----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------------
W
----------------------
E
----------------
K
D
A
W
E
I
P
R
E
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
K
-----
H
---
T
-
K
-
V
A
V
K
T
M
K
P
---------------
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
--
S
-
K
Q
P
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
---
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
---
123
Blastp_CBE
65.59
66%
-156
- C2 -
-
4KIO
2
ITK_HUMAN
B:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
---
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
------------
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
-------
166
Blastp_CBE
65.54
38%
8
- C2 -
-
3VS7
1
HCK_HUMAN
A:
[10-448]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
E
-
S
-
G
-
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
--
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
N
M
L
G
S
F
M
I
R
D
S
E
T
-
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
-
V
-
K
H
Y
K
I
R
--
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------------
W
----------------------
E
----------------
K
D
A
W
E
I
P
R
E
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
K
-----
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
--
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
--
S
-
K
Q
P
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
---------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
---
67
Blastp_CBE
65.53
67%
-141
- C2 -
-
1SNU
1
ITK_HUMAN
A:
[2-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
R
E
G
A
--
M
---
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
-------
148
Blastp_CBE
65.50
61%
-129
- C2 -
-
3SXR
1
B:
[4-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
K
R
E
E
I
T
--------
L
L
K
E
L
------
V
V
K
L
G
K
W
--
K
G
-----
Q
---
Y
-
D
-
V
A
V
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
F
Q
E
A
Q
T
M
M
K
L
S
H
P
K
L
V
K
F
Y
G
V
C
S
K
E
-
Y
P
-
I
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
S
-
H
-
G
-
K
--
G
-
L
E
-
P
-
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
D
R
D
L
C
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
D
---
Q
Y
--
V
S
-
S
V
G
T
K
-
F
P
V
K
W
S
A
P
E
V
F
H
Y
F
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
T
-
N
S
E
V
V
L
K
V
S
Q
G
H
R
L
Y
R
P
H
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
E
P
L
R
E
-------
121
Blastp_CBE
65.47
66%
-147
- C2 -
-
4KIO
3
D:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
----------
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
-------
38
Blastp_CBE
65.45
62%
-133
- C2 -
-
3PIY
1
A:
[6-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
----------------
Y
G
S
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
-----------
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
--
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
177
Blastp_CBE
65.43
38%
3
- C2 -
-
3VS1
1
HCK_HUMAN
B:
[10-448]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
E
-
S
-
G
-
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
--
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
N
M
L
G
S
F
M
I
R
D
S
E
T
-
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
-
V
-
K
H
Y
K
I
R
--
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------------
W
----------------------
E
----------------
K
D
A
W
E
I
P
R
E
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
K
-----
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
--
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
--
S
-
K
Q
P
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
---
79
Blastp_CBE
65.37
67%
-153
- C2 -
-
3V5J
1
ITK_HUMAN
A:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
-
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
R
E
G
-------
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
-
R
S
-
N
S
E
V
V
E
D
I
S
T
G
-
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
-------
175
Blastp_CBE
65.34
38%
8
- C2 -
-
3VS2
1
HCK_HUMAN
B:
[10-448]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
E
-
S
-
G
-
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
--
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
N
M
L
G
S
F
M
I
R
D
S
E
T
-
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
-
V
-
K
H
Y
K
I
R
--
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------------
W
----------------------
E
----------------
K
D
A
W
E
I
P
R
E
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
K
-----
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
--
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
--
S
-
K
Q
P
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
---
76
Blastp_CBE
65.33
67%
-150
- C2 -
-
3V5L
1
ITK_HUMAN
B:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
----
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
R
---------
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
-------
73
Blastp_CBE
65.15
67%
-148
- C2 -
-
3V8T
1
ITK_HUMAN
A:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
---
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
R
E
G
A
--
M
---
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-------
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
-------
82
Blastp_CBE
65.07
67%
-148
- C2 -
-
4RFM
1
A:
[4-258]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
R
E
G
A
--
M
---
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
---------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
------------
69
Blastp_CBE
65.05
67%
-145
- C2 -
-
1SM2
1
ITK_HUMAN
A:
[2-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
R
E
G
A
--
M
---
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
-------
149
Blastp_CBE
65.03
61%
-125
- C2 -
-
3SXR
1
BMX_HUMAN
A:
[4-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
K
R
E
E
I
T
--------
L
L
K
E
L
G
S
----
V
V
K
L
G
K
W
--
K
G
-----
Q
---
Y
-
D
-
V
A
V
K
M
I
K
E
G
S
--
M
---
S
E
D
--
E
F
F
Q
E
A
Q
T
M
M
K
L
S
H
P
K
L
V
K
F
Y
G
V
C
S
K
E
-
Y
P
-
I
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
S
-
H
-
G
-
K
--
G
-
L
E
-
P
-
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
D
R
D
L
C
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
D
---
Q
Y
--
V
S
-
S
V
G
T
K
-
F
P
V
K
W
S
A
P
E
V
F
H
Y
F
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
T
-
N
S
E
V
V
L
K
V
S
Q
G
H
R
L
Y
R
P
H
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
E
P
L
R
E
-------
106
Blastp_CBE
64.99
63%
-164
- C2 -
-
5XYZ
1
BTK_HUMAN
A:
[4-265]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
-------
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
-----
M
---
S
E
D
-----
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
--------
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
---------------------
F
P
V
R
W
S
P
P
E
V
L
M
---
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
-------
77
Blastp_CBE
64.98
67%
-146
- C2 -
-
3V5L
1
ITK_HUMAN
A:
[4-262]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
------
M
---
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
--------
36
Blastp_CBE
64.81
62%
-157
- C2 -
-
3PJ1
2
A:
[6-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
----------------
Y
G
S
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
---
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
----------
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
----
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
------
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-----------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
88
Blastp_CBE
64.77
67%
-151
- C2 -
-
3MIY
1
B:
[4-258]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
----------
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
------------
128
Blastp_CBE
64.64
65%
-145
- C2 -
-
3QGW
1
B:
[24-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
K
E
G
S
--
M
---
S
E
D
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
--------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
--------
34
Blastp_CBE
64.62
62%
-152
- C2 -
-
3PJ3
1
A:
[6-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
----------------
Y
G
S
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
---
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
------------
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
--------------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
126
Blastp_CBE
64.45
65%
-134
- C2 -
-
3QGY
1
B:
[24-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
K
E
G
S
--
M
---
S
E
D
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
--------
105
Blastp_CBE
64.45
63%
-153
- C2 -
-
5XYZ
1
B:
[4-265]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
-------
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
-----
M
---
S
E
D
--
E
-
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
---------------------
F
P
V
R
W
S
P
P
E
V
L
M
----
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
-------
80
Blastp_CBE
64.41
62%
-153
- C2 -
-
6NFI
1
A:
[1-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
----
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
---
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
----
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
----------------------
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
84
Blastp_CBE
64.38
67%
-143
- C2 -
-
4MF1
1
B:
[4-258]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
---
A
--
M
---
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
---------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
------------
554
HHSearch
64.24
38%
-52
- C2 -
-
3CBL
3
A:
[7-375]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
-
E
L
L
-
V
-----
H
S
G
D
F
L
V
R
E
S
-
Q
---
Q
E
Y
V
L
S
V
-----------
P
-
R
H
F
I
I
-------
N
-
L
Y
R
L
----
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
P
L
-----
V
V
L
H
---------
R
------
A
-----
V
----------------------
P
----------------
K
D
K
W
V
L
N
H
E
D
L
V
--------
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
--
R
A
D----
N
---
T
-
L
-
V
A
V
K
S
C
R
E
T
L
PP
D
---
L
K
A
--
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
-
Q
P
-
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
-
E
-
G
-
A
--
R
-
L
R
-
V
-
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
---
V
Y
--
A
A
S
G
G
L
R
Q
-
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
-
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
------
83
Blastp_CBE
64.13
67%
-139
- C2 -
-
4PQN
2
A:
[4-258]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
R
E
G
A
--
M
---
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
------------
28
Blastp_CBE
64.13
62%
-148
- C2 -
-
3K54
1
A:
[16-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
--------------
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
-
M
-
R
-
H
--
R
-
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
------------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
497
Blastp_CBE
63.98
37%
-9
- C2 -
-
3BKB
9
A:
[10-372]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
-
E
L
L
-
V
-----
H
S
G
D
F
L
V
R
E
S
-
Q
-
G
K
Q
E
Y
V
L
S
V
L
W
-------
D
G
L
P
R
H
F
I
I
Q
----
S
L
D
N
L
Y
R
L
E
G
E
G
F
P
S
I
P
L
L
I
D
H
--------
L
L
S
T
Q
Q
P
L
T
-
K
K
S
G
V
V
L
H
R
------
A
-----
V
----------------------
P
----------------
K
D
K
W
V
L
N
H
E
D
L
V
--------
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
--
R
A
-----
D
---
N
-
T
L
V
A
V
K
S
C
R
E
T
L
--
P
PD-
L
K
A
--
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
-
Q
P
-
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
-
E
-
G
-
A
--
R
-
L
R
-
V
-
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
---
V
Y
--
A
A
-
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
-
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
---------
131
Blastp_CBE
63.96
62%
-155
- C2 -
-
5JRS
1
B:
[4-263]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
--------
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
G
-----
Q
---
Y
-
D
-
V
A
I
K
M
I
K
--
S
--
M
---
S
E
D
--
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
------
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
----------
F
Q
-
T
-
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
-----------------
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
--------
89
Blastp_CBE
63.87
67%
-151
- C2 -
-
3MIY
1
ITK_HUMAN
A:
[4-258]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
----------
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
--------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
------------
85
Blastp_CBE
63.64
67%
-144
- C2 -
-
4MF1
1
ITK_HUMAN
A:
[4-258]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
---
A
--
M
---
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
------------
163
Blastp_CBE
63.28
38%
-1
- C2 -
-
4LUD
3
HCK_HUMAN
B:
[10-448]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
E
-
S
-
G
-
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
--
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
-
P
-
G
N
M
L
G
S
F
M
I
R
D
S
E
T
----
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
-
V
-
K
H
Y
K
I
-------------------
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
---------------
W
----------------------
E
----------------
K
D
A
W
E
I
P
R
E
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
K
-----
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
-------
S
V
E
--
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
--
S
-
K
Q
P
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
---
495
Blastp_CBE
63.13
37%
-23
- C2 -
-
4E93
1
A:
[10-372]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
-
E
L
L
-
V
-----
H
S
G
D
F
L
V
R
E
S
-
Q
---
Q
E
Y
V
L
S
V
L
W
-------
D
G
L
P
R
H
F
I
I
Q
----
S
L
D
N
L
Y
R
L
E
G
E
G
F
P
S
I
P
L
L
I
D
H
--------
L
L
S
T
Q
Q
P
L
T
-
K
K
S
G
V
V
L
H
R
------
A
-----
V
----------------------
P
----------------
K
D
K
W
V
L
N
H
E
D
L
V
--------
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
--
R
A
-----
D
---
N
-
T
L
V
A
V
K
S
C
R
E
T
L
--
P
PD-
L
K
A
--
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
-
Q
P
-
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
-
E
-
G
-
A
--
R
-
L
R
-
V
-
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
--------------------
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
-
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
---------
494
Blastp_CBE
62.68
37%
-7
- C2 -
-
6JMF
1
A:
[8-370]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
-
E
L
L
-
V
-----
H
S
G
D
F
L
V
R
E
S
-
Q
-
G
K
Q
E
Y
V
L
S
V
L
W
-------
D
G
L
P
R
H
F
I
I
Q
----
S
L
D
N
L
Y
R
L
E
G
E
G
F
P
S
I
P
L
L
I
D
H
--------
L
L
S
T
Q
Q
P
L
T
K
K
S
G
V
V
L
H
R
A
------------
V
----------------------
P
----------------
K
D
K
W
V
L
N
H
E
D
L
V
--------
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
--
R
A
-----
D
---
N
-
T
L
V
A
V
K
S
C
R
E
T
L
--
P
PD-
L
K
A
--
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
-
Q
P
-
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
-
E
-
G
-
A
--
R
-
L
R
-
V
-
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
---
V
Y
--
A
A
-
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
-
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
---------
153
Blastp_CBE
62.48
40%
-6
- C2 -
-
1OPL
1
ABL1_HUMAN
B:
[140-517]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
-
Y
L
L
---
S
-
S
G
I
N
G
S
F
L
V
R
E
S
E
S
-
S
P
G
Q
R
S
I
S
L
--
R
Y
E
G
-------
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
---------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
108
Blastp_CBE
62.41
66%
-146
- C2 -
-
4QD6
2
ITK_HUMAN
A:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
----------
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
-------
114
Blastp_CBE
61.73
66%
-154
- C2 -
-
4PPA
2
ITK_HUMAN
A:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
------------
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
-------
87
Blastp_CBE
61.54
67%
-151
- C2 -
-
3MJ1
1
A:
[4-258]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
------------------
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
--------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
-
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
------------
107
Blastp_CBE
61.30
66%
-148
- C2 -
-
4QD6
2
B:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
-----------
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
-------
118
Blastp_CBE
61.24
66%
-151
- C2 -
-
4MF0
2
ITK_HUMAN
A:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
---
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
------
M
---
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
-------
113
Blastp_CBE
61.14
66%
-152
- C2 -
-
4PPA
2
B:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
------------
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
-------
110
Blastp_CBE
60.95
66%
-156
- C2 -
-
4PPC
2
ITK_HUMAN
A:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
-----------------
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
--------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
-------
111
Blastp_CBE
60.75
66%
-147
- C2 -
-
4PPB
2
B:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
------------
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
-------
558
HHSearch
60.48
32%
-7
- C2 -
-
4FL3
1
KSYK_HUMAN
A:
[160-633]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
A
H
E
K
M
P
W
F
H
G
K
I
S
R
E
E
S
E
-
Q
I
V
L
I
-
G
-
S
K
T
N
G
K
F
L
I
R
A
R
-
D
-
N
N
G
S
Y
A
L
C
L
L
H
------
E
G
K
V
-
L
H
Y
R
I
D
K
D
--
K
T
G
K
L
S
I
P
E
G
K
K
F
D
T
L
W
Q
L
V
E
H
Y
S
Y
K
A
D
G
L
L
R
V
L
T
V
P
C
Q
K
---------------------------------------------REALPMDTEVFESPF-
A
D
P
E
E
I
R
P
K
E
V
Y
LDRKLLTL
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
M
-----
K
KVV
K
-
T
-
V
A
V
K
I
L
K
N
E
A
--
N
DPA
L
K
D
--
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
--
E
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
---
R
--
H
-
V
K
-
D
-
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
------------------
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
V
-----
112
Blastp_CBE
60.08
66%
-149
- C2 -
-
4PPB
2
ITK_HUMAN
A:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
------------
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
-------
117
Blastp_CBE
59.66
66%
-149
- C2 -
-
4MF0
2
B:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
---
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
------
M
---
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
--------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
-------
557
HHSearch
59.55
32%
8
- C2 -
-
4FL2
1
KSYK_HUMAN
A:
[162-634]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
H
E
K
M
P
W
F
H
G
K
I
S
R
E
E
S
E
-
Q
I
V
L
I
-
G
-
S
K
T
N
G
K
F
L
I
R
A
R
-
D
-
N
N
G
S
Y
A
L
C
L
L
H
------
E
G
K
V
-
L
H
Y
R
I
D
K
D
--
K
T
G
K
L
S
I
P
E
G
K
K
F
D
T
L
W
Q
L
V
E
H
Y
S
Y
K
A
D
G
L
L
R
V
L
T
V
P
C
Q
K
I
G
T
-------------------QREALPMDTEVYESPYADPEEI
R
----------------
P
K
E
V
Y
L
D
R
K
L
L
T
L-------
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
M
-----
K
KVV
K
-
T
-
V
A
V
K
I
L
K
N
E
A
--
N
DPA
L
K
D
--
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
--
E
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
---
R
--
H
-
V
K
-
D
-
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
---
E
N
YY
K
A
-
Q
T
H
G
K
-
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
V
-----
496
Blastp_CBE
59.11
37%
-12
- C2 -
-
3CBL
3
A:
[10-372]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
-
E
L
L
-
V
-----
H
S
G
D
F
L
V
R
E
S
-
Q
---
Q
E
Y
V
L
S
V
------------P
R
H
F
I
I
--------
N
L
Y
R
L
----
F
P
S
I
P
L
L
I
D
H
--------
L
L
S
T
Q
Q
P
L
------
V
V
L
H
R
------
A
-----
V
----------------------
P
----------------
K
D
K
W
V
L
N
H
E
D
L
V
--------
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
--
R
A
-----
D
---
N
-
T
L
V
A
V
K
S
C
R
E
T
L
--
P
PD-
L
K
A
--
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
-
Q
P
-
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
-
E
-
G
-
A
--
R
-
L
R
-
V
-
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
---
V
Y
--
A
A
-
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
-
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
---------
202
Blastp_CBE
59.07
42%
-13
- C2 -
-
4XEY
1
ABL1_HUMAN
B:
[7-383]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
-
Y
L
L
---
S
-
S
G
I
N
G
S
F
L
V
R
E
S
E
S
-
S
P
G
Q
R
S
I
S
L
--
R
Y
E
G
-------
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
---
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
--
K
-----------------------------------------------------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
------
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
---
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
109
Blastp_CBE
58.91
66%
-149
- C2 -
-
4PPC
2
B:
[4-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
--------
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
--
L
N
-----
K
---
D
-
K
-
V
A
I
K
T
I
-----------------
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
---
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
-
R
-
G
--
L
-
F
A
-
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
--------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
-------
556
HHSearch
57.95
33%
-9
- C2 -
-
4K2R
1
ZAP70_HUMAN
A:
[155-600]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
A
H
E
R
M
P
W
Y
H
S
S
L
T
R
E
E
A
E
-
R
K
L
-
Y
-
S
G
A
Q
T
D
G
K
F
L
L
R
P
R
-
K
-
E
Q
G
T
Y
A
L
S
L
I
Y
------
G
K
T
V
-
Y
H
Y
L
I
S
Q
D
--
K
A
G
K
Y
C
I
P
E
G
T
K
F
D
T
L
W
Q
L
V
E
Y
L
K
L
K
A
D
G
L
I
Y
C
L
K
E
A
C
P
N
S
--------DKPRPM
P
-----
M
----------------------
D
TSVYESPYSDPEELKD
K
K
L
F
L
K
R
D
N
L
L
I
--------
A
D
I
E
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
--
R
M
RKK--
Q
---
I
-
D
-
V
A
I
K
V
L
K
Q
G
T
--
E
KA-
D
T
E
--
E
M
M
R
E
A
Q
I
M
H
Q
L
D
N
P
Y
I
V
R
L
I
G
V
C
Q
A
--
E
A
-
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
G
-
K
-
R
-
E
--
E
-
I
P
-
V
-
S
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
N
L
A
A
R
N
V
L
L
V
N
R
H
Y
A
K
I
S
D
F
G
L
S
----------------------
W
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
Q
K
P
Y
K
K
M
K
-
G
P
E
V
M
A
F
I
E
Q
G
K
R
M
E
C
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
Y
S
L
-----
555
HHSearch
57.85
41%
-16
- C2 -
-
4XEY
1
ABL1_HUMAN
B:
[7-384]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
-
Y
L
L
-
S
---
S
G
I
N
G
S
F
L
V
R
E
S
-
E
S
S
P
G
Q
R
S
I
S
L
R
Y
------
E
G
R
V
-
Y
H
Y
R
I
N
T
A
--
S
D
G
K
L
Y
V
---
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
K
-------------------------------------------------------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
------
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
---
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
-
N
R
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
------
525
Fugue
57.53
37%
-37
- C2 -
-
3CD3
3
A:
[1-376]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
I
P
E
V
Q
K
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
-
E
L
L
-
V
-
H
-
S
---
G
D
F
L
V
R
E
S
-
Q
-
E
---
Y
V
L
S
V
------------------------
P
R
H
F
I
I
N
L
Y
R
L
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
P
L
S
G
V
V
L
H
R
A
V
P
K
-------------------------------------------------------------
D
K
W
V
L
N
H
E
D
L
V
--------
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
--
R
A
-----
D
---
N
T
L
-
V
A
V
K
S
C
R
P
D
L
--
K
---
A
K
----
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
-
Q
P
-
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
-
E
-
G
-
A
--
R
-
L
R
-
V
-
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
---
V
A
--
A
S
-
G
G
L
R
Q
-
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
-
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
H
-----
258
Blastp_CBE
54.51
44%
-64
- C2 -
-
3CS9
1
ABL1_HUMAN
D:
[10-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
---------------
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
498
Blastp_CBE
54.46
36%
-12
- C2 -
-
3CD3
3
A:
[10-372]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
-
E
L
L
-
V
-----
H
S
G
D
F
L
V
R
E
S
-----
Q
E
Y
V
L
S
V
------------P
R
H
F
I
I
--------
N
L
Y
R
L
----
F
P
S
I
P
L
L
I
D
H
--------
L
L
S
T
Q
Q
P
L
----
S
G
V
V
L
H
R
------
A
-----
V
----------------------
P
----------------
K
D
K
W
V
L
N
H
E
D
L
V
--------
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
--
R
A
-----
D
---
N
-
T
L
V
A
V
K
S
C
R
------PD-
L
K
A
--
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
-
Q
P
-
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
-
E
-
G
-
A
--
R
-
L
R
-
V
-
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
---
V
A
--
A
S
-
G
G
L
R
Q
-
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
-
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
---------
559
HHSearch
54.36
33%
-9
- C2 -
-
2OZO
1
ZAP70_HUMAN
A:
[155-600]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
A
H
E
R
M
P
W
Y
H
S
S
L
T
R
E
E
A
E
-
R
K
L
-
Y
S
G
-
A
Q
T
D
G
K
F
L
L
R
P
R
-
K
-
E
Q
G
T
Y
A
L
S
L
I
Y
------
G
K
T
V
-
Y
H
Y
L
I
S
Q
D
--
K
A
G
K
Y
C
I
P
E
G
T
K
F
D
T
L
W
Q
L
V
E
Y
L
K
L
K
A
D
G
L
I
Y
C
L
K
E
A
C
P
N
----------------MDTSV
F
----------------------
E
SPFSDPEELKD-----
K
K
L
F
L
K
R
D
N
L
L
I
--------
A
D
I
E
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
--
R
M
RKK--
Q
---
I
-
D
-
V
A
I
K
V
L
K
Q
G
T
--
E
KA-
D
T
E
--
E
M
M
R
E
A
Q
I
M
H
Q
L
D
N
P
Y
I
V
R
L
I
G
V
C
Q
A
--
E
A
-
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
G
-
K
-
R
-
E
--
E
-
I
P
-
V
-
S
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
N
L
A
A
R
N
V
L
L
V
N
R
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
G
-------------------
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
Q
K
P
Y
K
K
M
K
-
G
P
E
V
M
A
F
I
E
Q
G
K
R
M
E
C
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
Y
S
L
-----
448
Blastp_CBE
54.36
47%
-75
- C2 -
-
3U4W
4
A:
[2-254]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
--
T
A
-
R
Q
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
432
Blastp_CBE
53.78
42%
-67
- C2 -
-
5ZJ6
1
HCK_HUMAN
A:
[19-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
K
-----
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
--
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
--
S
-
K
Q
P
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
---
E
Y
--
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
-----
431
Blastp_CBE
53.67
42%
-65
- C2 -
-
5ZJ6
1
HCK_HUMAN
B:
[19-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
K
-----
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
--
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
--
S
-
K
Q
P
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
---
E
Y
--
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
-----
335
Blastp_CBE
53.45
44%
-67
- C2 -
-
3B2W
1
LCK_HUMAN
A:
[13-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
R
E
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
G
-----
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
--
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
--
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
-
S
-
G
I-
K
-
L
T
-
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
--
T
A
---
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
-
D
Y
L
R
S
V
L
E
----------
341
Blastp_CBE
53.43
44%
-64
- C2 -
-
2PL0
1
LCK_HUMAN
A:
[16-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
E
V
P
R
E
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
G
-----
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
--
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
--
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
-
S
-
G
I-
K
-
L
T
-
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
--
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
-
D
Y
L
R
S
V
L
E
----------
449
Blastp_CBE
53.19
43%
-58
- C2 -
-
2HK5
1
HCK_HUMAN
A:
[8-269]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
K
--------
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
K
-----
H
---
T
-
K
-
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
--
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
--
S
-
K
Q
P
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
---
E
Y
--
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
---------
489
Blastp_CBE
52.85
46%
-68
- C2 -
-
3DQW
1
SRC_CHICK
B:
[8-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----------------------
A
----------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
I
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
--
T
A
-
R
Q
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
443
Blastp_CBE
52.64
42%
-67
- C2 -
-
2ZVA
1
LYN_MOUSE
A:
[7-269]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
R
E
S
I
K
--------
L
V
K
K
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
N
-----
S
---
T
-
K
-
V
A
V
K
T
L
K
P
G
T
--
M
---
S
V
Q
--
A
F
L
E
E
A
N
L
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
V
V
T
K
E
-
E
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
G-
K
-
V
L
-
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
I
E
---------
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
N
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
T
-
N
A
D
V
M
S
A
L
S
Q
G
Y
R
M
P
R
M
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
F
Y
T
-------
490
Blastp_CBE
52.63
46%
-69
- C2 -
-
3DQW
1
SRC_CHICK
A:
[8-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----------------------
A
----------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
I
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
--
T
A
-
R
Q
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
488
Blastp_CBE
52.58
46%
-69
- C2 -
-
3DQW
1
SRC_CHICK
C:
[11-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
I
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
--
T
A
-
R
Q
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
487
Blastp_CBE
52.39
46%
-67
- C2 -
-
3DQW
1
SRC_CHICK
D:
[10-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
I
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
--
T
A
-
R
Q
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
459
Blastp_CBE
52.39
44%
-54
- C2 -
-
3KXZ
1
LCK_HUMAN
A:
[16-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
R
E
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
G
-----
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
--
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
--
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
-
S
-
G
I-
K
-
L
T
-
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
--
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
-
D
Y
L
R
S
V
L
E
----------
391
Blastp_CBE
52.22
44%
-59
- C2 -
-
2OF4
1
LCK_HUMAN
A:
[6-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
E
V
P
R
E
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
G
-----
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
--
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
--
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
-
S
-
G
I-
K
-
L
T
-
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
--
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
-
D
Y
L
R
S
V
L
E
----------
427
Blastp_CBE
52.03
42%
-71
- C2 -
-
5XY1
1
LYN_HUMAN
A:
[7-269]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
R
E
S
I
K
--------
L
V
K
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
N
-----
S
---
T
-
K
-
V
A
V
K
T
L
K
P
G
T
--
M
---
S
V
Q
--
A
F
L
E
E
A
N
L
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
V
V
T
R
E
-
E
P
-
I
Y
I
I
T
E
Y
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
G-
K
-
V
L
-
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
------------------
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
D
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
T
-
N
A
D
V
M
T
A
L
S
Q
G
Y
R
M
P
R
V
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
F
Y
T
-------
445
Blastp_CBE
51.97
42%
-68
- C2 -
-
2ZV8
1
LYN_MOUSE
A:
[7-268]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
R
E
S
I
K
--------
L
V
K
K
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
N
-----
S
---
T
-
K
-
V
A
V
K
T
L
K
P
G
T
--
M
---
S
V
Q
--
A
F
L
E
E
A
N
L
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
V
V
T
K
E
-
E
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
G-
K
-
V
L
-
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
I
-------------
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
N
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
T
-
N
A
D
V
M
S
A
L
S
Q
G
Y
R
M
P
R
M
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
F
Y
--------
279
Blastp_CBE
51.94
47%
-88
- C2 -
-
3F3W
1
SRC_CHICK
B:
[11-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
208
Blastp_CBE
51.94
47%
-81
- C2 -
-
3TZ8
1
SRC_CHICK
B:
[9-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
---------------------
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
392
Blastp_CBE
51.92
44%
-57
- C2 -
-
2OF2
1
LCK_HUMAN
A:
[6-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
E
V
P
R
E
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
G
-----
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
--
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
--
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
-
S
-
G
I-
K
-
L
T
-
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
--
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
-
D
Y
L
R
S
V
L
E
----------
382
Blastp_CBE
51.81
47%
-71
- C2 -
-
3DQX
1
SRC_CHICK
A:
[12-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
--------------
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
272
Blastp_CBE
51.73
47%
-79
- C2 -
-
5D12
1
SRC_CHICK
A:
[10-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
----------
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
315
Blastp_CBE
51.71
44%
-73
- C2 -
-
2OG8
1
LCK_HUMAN
A:
[2-260]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
W
E
V
P
R
E
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
G
-----
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
--
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
--
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
-
S
-
G
I-
K
-
L
T
-
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
------------------------
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
-
D
Y
L
R
S
V
L
E
----------
444
Blastp_CBE
51.58
42%
-65
- C2 -
-
2ZV9
1
LYN_MOUSE
A:
[7-268]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
R
E
S
I
K
--------
L
V
K
K
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
N
-----
S
---
T
-
K
-
V
A
V
K
T
L
K
P
G
T
--
M
---
S
V
Q
--
A
F
L
E
E
A
N
L
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
V
V
T
K
E
-
E
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
G-
K
-
V
L
-
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
I
--------------
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
N
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
T
-
N
A
D
V
M
S
A
L
S
Q
G
Y
R
M
P
R
M
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
F
Y
--------
350
Blastp_CBE
51.55
47%
-72
- C2 -
-
4YBK
1
SRC_CHICK
A:
[9-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
------------------
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
410
Blastp_CBE
51.54
44%
-58
- C2 -
-
3MPM
2
LCK_HUMAN
A:
[4-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
R
E
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
G
-----
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
--
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
--
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
-
S
-
G
I-
K
-
L
T
-
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
N
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
--
T
A
-
R
-----
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
-
D
Y
L
R
S
V
L
E
----------
280
Blastp_CBE
51.49
47%
-86
- C2 -
-
3F3W
1
SRC_CHICK
A:
[10-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
205
Blastp_CBE
51.51
52%
-46
- C2 -
-
4CSV
1
?
A:
[5-267]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
I
P
R
S
E
I
T
--------
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
--
R
N
Y----
N
---
I
-
E
-
V
A
V
K
T
L
K
E
G
T
--
M
---
S
V
E
--
E
F
L
Q
E
A
Q
I
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
T
K
E
-
P
P
-
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
-
C
--------
V
N
-
A
-
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
V
K
V
A
D
F
G
------------------------
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
-
G
S
E
V
I
E
Q
V
E
R
G
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
---------
246
Blastp_CBE
51.49
47%
-70
- C2 -
-
3GEQ
1
SRC_CHICK
B:
[5-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
------
G
-----
L
----------------------
A
----------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
A
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
369
Blastp_CBE
51.40
47%
-73
- C2 -
-
3F6X
1
SRC_CHICK
D:
[10-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
----------------
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
247
Blastp_CBE
51.40
47%
-68
- C2 -
-
3GEQ
1
SRC_CHICK
A:
[5-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
------
G
-----
L
----------------------
A
----------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
A
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
---------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
355
Blastp_CBE
51.39
47%
-73
- C2 -
-
4O2P
1
SRC_CHICK
B:
[9-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
-
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
270
Blastp_CBE
51.36
47%
-75
- C2 -
-
6HVE
1
?
A:
[9-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
371
Blastp_CBE
51.33
47%
-70
- C2 -
-
3F6X
1
SRC_CHICK
B:
[8-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----------------------
A
----------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
-
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
-----------------
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
349
Blastp_CBE
51.29
47%
-75
- C2 -
-
5J5S
1
SRC_CHICK
A:
[11-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
343
Blastp_CBE
51.29
47%
-71
- C2 -
-
5XP7
1
SRC_CHICK
A:
[10-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
385
Blastp_CBE
51.28
47%
-75
- C2 -
-
2OIQ
2
SRC_CHICK
A:
[9-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-------------------
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
403
Blastp_CBE
51.17
46%
-77
- C2 -
-
3OEZ
1
SRC_CHICK
B:
[9-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
409
Blastp_CBE
51.20
44%
-58
- C2 -
-
4C3F
1
LCK_HUMAN
A:
[4-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
R
E
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
G
-----
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
--
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
--
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
-
S
-
G
I-
K
-
L
T
-
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
N
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
--
T
A
-
R
-----
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
-
D
Y
L
R
S
V
L
E
----------
356
Blastp_CBE
51.13
47%
-75
- C2 -
-
4O2P
1
SRC_CHICK
A:
[10-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
----
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
-----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
354
Blastp_CBE
51.13
47%
-70
- C2 -
-
4U5J
1
SRC_CHICK
A:
[12-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
--------------
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
360
Blastp_CBE
51.15
47%
-75
- C2 -
-
4DGG
1
SRC_CHICK
A:
[9-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
214
Blastp_CBE
51.13
47%
-84
- C2 -
-
3F3V
1
SRC_CHICK
B:
[9-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
368
Blastp_CBE
51.12
47%
-70
- C2 -
-
3G6G
2
SRC_CHICK
A:
[9-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
--------------------
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
414
Blastp_CBE
51.03
46%
-81
- C2 -
-
5T0P
1
SRC_CHICK
A:
[10-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
C
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
366
Blastp_CBE
50.98
47%
-76
- C2 -
-
3UQF
1
SRC_CHICK
A:
[11-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
-----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
383
Blastp_CBE
50.97
47%
-81
- C2 -
-
3D7T
1
SRC_CHICK
B:
[11-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
-----------------
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
352
Blastp_CBE
50.91
47%
-74
- C2 -
-
4YBJ
1
SRC_CHICK
A:
[12-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
314
Blastp_CBE
50.94
44%
-64
- C2 -
-
2OG8
1
?
B:
[1-260]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
E
V
P
R
E
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
G
-----
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
--
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
--
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
-
S
-
G
I-
K
-
L
T
-
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
-----------------------
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
-
D
Y
L
R
S
V
L
E
----------
351
Blastp_CBE
50.91
47%
-81
- C2 -
-
4YBJ
1
SRC_CHICK
B:
[12-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
-----
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
347
Blastp_CBE
50.89
47%
-73
- C2 -
-
5K9I
1
SRC_CHICK
A:
[12-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
313
Blastp_CBE
50.85
45%
-18
- C2 -
-
2HZ0
1
ABL1_HUMAN
A:
[6-269]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
---------
211
Blastp_CBE
50.85
47%
-80
- C2 -
-
3TZ7
1
SRC_CHICK
A:
[10-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
209
Blastp_CBE
50.84
47%
-80
- C2 -
-
3TZ8
1
SRC_CHICK
A:
[10-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
420
Blastp_CBE
50.78
42%
-71
- C2 -
-
3A4O
1
LYN_HUMAN
X:
[6-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
I
K
--------
L
V
K
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
N
-----
S
---
T
-
K
-
V
A
V
K
T
L
K
P
G
T
--
M
---
S
V
Q
--
A
F
L
E
E
A
N
L
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
V
V
T
R
E
-
E
P
-
I
Y
I
I
T
E
Y
M
A
K
G
S
L
L
D
F
L
K
S
-
D
-
E
-
G
G-
K
-
V
L
-
L
-
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
---------------
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
D
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
T
-
N
A
D
V
M
T
A
L
S
Q
G
Y
R
M
P
R
V
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
F
Y
T
A
T
E
----
404
Blastp_CBE
50.75
46%
-77
* C2 *
-
3OEZ
1
SRC_CHICK
A:
[10-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
381
Blastp_CBE
50.71
47%
-66
- C2 -
-
3DQX
1
SRC_CHICK
B:
[12-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
-------------
Q
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
328
Blastp_CBE
50.70
47%
-69
- C2 -
-
4MXO
1
SRC_HUMAN
A:
[10-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
T
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
----------------
240
Blastp_CBE
50.65
45%
-11
- C2 -
-
1M52
3
ABL1_MOUSE
B:
[10-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
428
Blastp_CBE
50.57
46%
-68
- C2 -
-
2BDJ
1
A:
[3-258]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
T
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
----------------
417
Blastp_CBE
50.61
46%
-71
- C2 -
-
5SWH
1
SRC_CHICK
B:
[8-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----------------------
A
----------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
C
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
346
Blastp_CBE
50.59
47%
-77
- C2 -
-
5K9I
1
SRC_CHICK
B:
[12-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
329
Blastp_CBE
50.57
44%
-66
- C2 -
-
3BYU
1
LCK_HUMAN
A:
[12-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
E
V
P
R
E
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
G
-----
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
--
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
--
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
-
S
-
G
I-
K
-
L
T
-
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
---------------------
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
-
D
Y
L
R
S
V
L
E
----------
485
Blastp_CBE
50.45
44%
-9
- C2 -
-
2V7A
1
ABL1_HUMAN
B:
[8-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
377
Blastp_CBE
50.45
47%
-66
- C2 -
-
3EN4
1
SRC_CHICK
B:
[10-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
-----------------
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
207
Blastp_CBE
50.45
47%
-81
- C2 -
-
3TZ9
1
SRC_CHICK
A:
[10-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
342
Blastp_CBE
50.44
47%
-70
- C2 -
-
5XP7
2
SRC_CHICK
B:
[9-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
446
Blastp_CBE
50.43
47%
-75
- C2 -
-
3U51
1
B:
[3-254]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
212
Blastp_CBE
50.40
47%
-72
- C2 -
-
3G5D
2
SRC_CHICK
B:
[11-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
---
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
-----
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
447
Blastp_CBE
50.39
47%
-78
- C2 -
-
3U51
1
SRC_CHICK
A:
[3-254]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
359
Blastp_CBE
50.37
47%
-75
- C2 -
-
4DGG
1
SRC_CHICK
B:
[9-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
-------------
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
422
Blastp_CBE
50.36
46%
-66
- C2 -
-
3SVV
1
SRC_CHICK
A:
[10-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
-
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
C
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
345
Blastp_CBE
50.33
47%
-66
- C2 -
-
5XP5
1
SRC_CHICK
A:
[12-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
--------------
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
419
Blastp_CBE
50.27
46%
-79
- C2 -
-
3G6H
1
SRC_CHICK
B:
[11-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
I
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
367
Blastp_CBE
50.32
47%
-71
- C2 -
-
3G6G
2
SRC_CHICK
B:
[9-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
---------------------
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
379
Blastp_CBE
50.27
47%
-77
- C2 -
-
3EL8
1
SRC_CHICK
A:
[11-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
365
Blastp_CBE
50.27
47%
-70
- C2 -
-
3UQF
1
SRC_CHICK
B:
[9-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
------------
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
364
Blastp_CBE
50.30
47%
-74
- C2 -
-
3UQG
1
SRC_CHICK
A:
[11-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
218
Blastp_CBE
50.27
47%
-83
- C2 -
-
3F3T
2
SRC_CHICK
A:
[10-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
421
Blastp_CBE
50.14
46%
-75
- C2 -
-
3SVV
1
SRC_CHICK
B:
[9-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
---
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
-
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
C
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
327
Blastp_CBE
50.23
47%
-69
- C2 -
-
4MXO
1
SRC_HUMAN
B:
[11-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
T
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
----------------
290
Blastp_CBE
50.21
44%
-3
- C2 -
-
2G1T
1
ABL1_HUMAN
B:
[6-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
375
Blastp_CBE
50.20
47%
-74
- C2 -
-
3EN5
1
SRC_CHICK
B:
[9-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
413
Blastp_CBE
50.14
46%
-77
- C2 -
-
5T0P
1
SRC_CHICK
B:
[11-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
C
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
418
Blastp_CBE
50.16
46%
-69
- C2 -
-
5SWH
1
SRC_CHICK
A:
[11-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
C
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
325
Blastp_CBE
50.14
47%
-65
- C2 -
-
4MXX
1
SRC_HUMAN
A:
[10-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
T
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
T
D
F
G
L
A
R
L
I
E
------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
----------------
241
Blastp_CBE
50.12
45%
-7
- C2 -
-
1M52
1
ABL1_MOUSE
A:
[10-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
425
Blastp_CBE
50.03
46%
-73
- C2 -
-
4MXY
1
SRC_HUMAN
B:
[11-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
L
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
T
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
----------------
323
Blastp_CBE
50.09
44%
-12
- C2 -
-
3PYY
1
ABL1_HUMAN
A:
[18-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
---------
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
215
Blastp_CBE
50.07
47%
-84
- C2 -
-
3F3V
1
SRC_CHICK
A:
[10-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
273
Blastp_CBE
50.06
47%
-77
- C2 -
-
5D11
2
SRC_CHICK
B:
[10-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
----------------
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
362
Blastp_CBE
50.01
47%
-72
- C2 -
-
4AGW
3
SRC_CHICK
A:
[10-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
423
Blastp_CBE
50.03
46%
-73
- C2 -
-
4MXZ
1
SRC_HUMAN
B:
[11-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
L
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
T
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
----------------
486
Blastp_CBE
49.95
44%
-9
- C2 -
-
2V7A
1
ABL1_HUMAN
A:
[7-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
305
Blastp_CBE
50.02
44%
-7
- C2 -
-
2G2H
1
ABL1_HUMAN
B:
[8-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
P
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
433
Blastp_CBE
49.95
44%
-9
- C2 -
-
4TWP
1
ABL1_HUMAN
B:
[1-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
308
Blastp_CBE
50.01
44%
-7
- C2 -
-
2G2F
1
ABL1_HUMAN
A:
[7-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
P
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
430
Blastp_CBE
49.97
46%
-69
- C2 -
-
2BDF
1
SRC_HUMAN
A:
[3-258]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
T
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
----------------
336
Blastp_CBE
49.95
44%
-72
- C2 -
-
2OFV
1
?
B:
[11-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
E
V
P
R
E
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
G
-----
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
------------
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
--
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
-
S
-
G
I-
K
-
L
T
-
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
------------------
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
--------
I
Q
N
L
E
-
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
-
D
Y
L
R
S
V
L
E
----------
348
Blastp_CBE
49.94
47%
-69
- C2 -
-
5J5S
1
SRC_CHICK
B:
[9-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
--
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
452
Blastp_CBE
49.93
44%
-9
- C2 -
-
2GQG
2
ABL1_HUMAN
B:
[9-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
399
Blastp_CBE
49.87
46%
-71
- C2 -
-
3QLG
1
SRC_CHICK
B:
[9-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
-----
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
344
Blastp_CBE
49.92
47%
-68
- C2 -
-
5XP5
1
SRC_CHICK
B:
[12-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
--------------
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
372
Blastp_CBE
49.91
47%
-70
- C2 -
-
3F6X
1
SRC_CHICK
A:
[8-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----------------------
A
----------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
----------
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
----------------
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
213
Blastp_CBE
49.90
47%
-70
- C2 -
-
3G5D
2
SRC_CHICK
A:
[10-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
---
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
----------
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
306
Blastp_CBE
49.88
44%
-6
- C2 -
-
2G2H
1
ABL1_HUMAN
A:
[8-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
P
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
330
Blastp_CBE
49.87
44%
-69
- C2 -
-
3BYS
1
LCK_HUMAN
A:
[12-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
E
V
P
R
E
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
G
-----
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
--
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
--
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
-
S
-
G
I-
K
-
L
T
-
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
------------------------
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
-
D
Y
L
R
S
V
L
E
----------
238
Blastp_CBE
49.78
45%
-9
- C2 -
-
1OPJ
2
ABL1_MOUSE
B:
[9-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
243
Blastp_CBE
49.75
45%
-9
- C2 -
-
1IEP
1
ABL1_MOUSE
A:
[9-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
254
Blastp_CBE
49.74
45%
-10
- C2 -
-
2QOH
1
ABL1_MOUSE
A:
[4-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
--------
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
206
Blastp_CBE
49.71
47%
-80
- C2 -
-
3TZ9
1
SRC_CHICK
B:
[10-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
-------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
337
Blastp_CBE
49.70
44%
-69
- C2 -
-
2OFV
1
LCK_HUMAN
A:
[11-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
E
V
P
R
E
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
G
-----
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
--------------
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
--
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
-
S
-
G
I-
K
-
L
T
-
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
------------------------
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
-
D
Y
L
R
S
V
L
E
----------
224
Blastp_CBE
49.68
47%
-79
- C2 -
-
2HWO
2
SRC_CHICK
A:
[8-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----------------------
A
----------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
-
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
--------------
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
----
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
239
Blastp_CBE
49.67
45%
-5
- C2 -
-
1OPJ
2
ABL1_MOUSE
A:
[9-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
217
Blastp_CBE
49.66
47%
-83
- C2 -
-
3F3U
2
SRC_CHICK
A:
[10-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
263
Blastp_CBE
49.65
44%
-6
- C2 -
-
2HZI
1
ABL1_HUMAN
A:
[10-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
453
Blastp_CBE
49.53
44%
-10
- C2 -
-
2GQG
2
ABL1_HUMAN
A:
[9-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
407
Blastp_CBE
49.53
46%
-74
- C2 -
-
1YOM
1
SRC_HUMAN
B:
[5-262]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----------------------
A
----------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
G
-
E
-
T
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
-------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
----------------
370
Blastp_CBE
49.57
47%
-66
- C2 -
-
3F6X
1
SRC_CHICK
C:
[8-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----------------------
A
----------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
---------
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
----------------
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
400
Blastp_CBE
49.56
46%
-70
- C2 -
-
3QLG
1
SRC_CHICK
A:
[11-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
332
Blastp_CBE
49.55
44%
-11
- C2 -
-
3OY3
1
ABL1_MOUSE
A:
[4-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
338
Blastp_CBE
49.53
44%
-13
- C2 -
-
3IK3
1
ABL1_MOUSE
B:
[4-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
507
Blastp_CBE
49.50
40%
-40
- C2 -
-
6Q7B
1
?
A:
[13-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
H
P
S
C
V
T
--------
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
--
K
T
K----
E
---
V
-
P
-
V
A
I
K
T
L
K
A
G
Y
--
T
---
E
K
Q
RV
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
-
D
-
G
--
E
-
F
S
-
V
-
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
-------------------
G
K
-
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
--
340
Blastp_CBE
49.46
44%
-14
- C2 -
-
2Z60
1
ABL1_MOUSE
A:
[4-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
--------
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
331
Blastp_CBE
49.48
44%
-12
- C2 -
-
3OY3
1
ABL1_MOUSE
B:
[4-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
378
Blastp_CBE
49.47
47%
-74
- C2 -
-
3EN4
1
SRC_CHICK
A:
[11-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
----
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
252
Blastp_CBE
49.46
45%
-12
- C2 -
-
3KF4
1
ABL1_MOUSE
A:
[4-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
----------
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
394
Blastp_CBE
49.40
44%
-11
- C2 -
-
3DK3
1
ABL1_MOUSE
A:
[4-269]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
---------
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
F
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
291
Blastp_CBE
49.40
44%
-1
- C2 -
-
2G1T
1
ABL1_HUMAN
A:
[7-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
245
Blastp_CBE
49.38
45%
-3
- C2 -
-
1FPU
1
ABL1_MOUSE
A:
[9-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
253
Blastp_CBE
49.37
45%
-9
- C2 -
-
2QOH
1
ABL1_MOUSE
B:
[4-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
-----
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
502
Blastp_CBE
49.29
40%
-37
- C2 -
-
6Q7G
1
?
A:
[13-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
H
P
S
C
V
T
--------
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
--
K
T
K----
E
---
V
-
P
-
V
A
I
K
T
L
K
A
G
Y
--
T
---
E
K
Q
RV
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
-
D
-
G
--
E
-
F
S
-
V
-
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
--
292
Blastp_CBE
49.35
44%
-8
- C2 -
-
4WA9
1
ABL1_HUMAN
B:
[7-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
429
Blastp_CBE
49.34
46%
-66
- C2 -
-
2BDF
1
B:
[1-258]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----------------------
A
----------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
T
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
---------------
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
----------------
353
Blastp_CBE
49.33
47%
-72
- C2 -
-
4U5J
1
SRC_CHICK
B:
[12-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
--------------
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
228
Blastp_CBE
49.31
45%
-5
- C2 -
-
6HD4
3
ABL1_MOUSE
A:
[9-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
---
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
426
Blastp_CBE
49.24
46%
-72
- C2 -
-
4MXY
1
SRC_HUMAN
A:
[10-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
L
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
T
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
----------------
265
Blastp_CBE
49.30
44%
-9
- C2 -
-
4ZOG
5
ABL1_HUMAN
A:
[5-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
302
Blastp_CBE
49.29
44%
-2
- C2 -
-
2HIW
1
ABL1_HUMAN
A:
[6-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
317
Blastp_CBE
49.22
44%
-11
- C2 -
-
6NPV
2
ABL1_HUMAN
A:
[18-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
----------
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
288
Blastp_CBE
49.22
44%
3
- C2 -
-
2G1T
1
ABL1_HUMAN
D:
[6-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
424
Blastp_CBE
49.24
46%
-72
- C2 -
-
4MXZ
1
SRC_HUMAN
A:
[10-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
L
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
T
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
----------------
236
Blastp_CBE
49.23
45%
-6
- C2 -
-
3K5V
2
ABL1_MOUSE
A:
[9-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
---
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
226
Blastp_CBE
49.22
45%
-8
- C2 -
-
6HD6
2
ABL1_MOUSE
A:
[9-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
----
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
508
Blastp_CBE
49.21
40%
-34
- C2 -
-
6HEY
1
A:
[13-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
H
P
S
C
V
T
--------
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
--
K
T
S----
E
---
V
-
P
-
V
A
I
K
T
L
K
A
G
Y
--
T
---
E
K
Q
RV
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
-
D
-
G
--
E
-
F
S
-
V
-
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
--------------------
K
-
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
--
416
Blastp_CBE
49.19
46%
-72
- C2 -
-
5SYS
1
SRC_CHICK
A:
[11-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
C
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
358
Blastp_CBE
49.08
47%
-80
- C2 -
-
4FIC
1
SRC_CHICK
A:
[8-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----------------------
A
----------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
---
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
---------------
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
506
Blastp_CBE
49.04
40%
-41
- C2 -
-
6Q7C
1
?
A:
[13-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
H
P
S
C
V
T
--------
R
Q
K
V
I
G
A
--
F
G
E
V
Y
K
G
M
L
--
K
T
K----
E
---
V
-
P
-
V
A
I
K
T
L
K
A
G
Y
--
T
---
E
K
Q
RV
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
-
D
-
G
--
E
-
F
S
-
V
-
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
-------------------
G
K
-
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
--
361
Blastp_CBE
49.07
47%
-67
- C2 -
-
4AGW
2
SRC_CHICK
B:
[11-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
220
Blastp_CBE
49.10
47%
-81
- C2 -
-
2QLQ
2
SRC_CHICK
A:
[9-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
--------------------
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
289
Blastp_CBE
49.08
44%
-1
- C2 -
-
2G1T
1
ABL1_HUMAN
C:
[7-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
274
Blastp_CBE
49.07
47%
-79
- C2 -
-
5D11
2
SRC_CHICK
A:
[11-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
--------
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
321
Blastp_CBE
49.05
44%
-9
- C2 -
-
6NPE
2
ABL1_HUMAN
A:
[18-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
----------
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
286
Blastp_CBE
49.02
44%
-7
- C2 -
-
3UE4
1
ABL1_HUMAN
B:
[8-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
--
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
257
Blastp_CBE
49.04
44%
-5
- C2 -
-
3QRI
1
ABL1_HUMAN
A:
[9-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
244
Blastp_CBE
49.02
45%
-0
- C2 -
-
1FPU
1
ABL1_MOUSE
B:
[9-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
--------
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
242
Blastp_CBE
49.01
45%
-9
- C2 -
-
1IEP
1
ABL1_MOUSE
B:
[9-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
415
Blastp_CBE
48.99
46%
-70
- C2 -
-
5SYS
1
SRC_CHICK
B:
[11-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
C
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
412
Blastp_CBE
48.92
46%
-72
- C2 -
-
5TEH
1
SRC_CHICK
A:
[9-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
C
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
249
Blastp_CBE
48.94
45%
-6
- C2 -
-
3KFA
1
ABL1_MOUSE
B:
[4-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
210
Blastp_CBE
48.94
47%
-77
- C2 -
-
3TZ7
1
SRC_CHICK
B:
[10-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
411
Blastp_CBE
48.92
46%
-75
- C2 -
-
5TEH
1
SRC_CHICK
B:
[9-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
C
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
297
Blastp_CBE
48.90
44%
-5
- C2 -
-
2HYY
1
ABL1_HUMAN
D:
[6-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
----
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
454
Blastp_CBE
48.88
46%
-68
- C2 -
-
4MCV
1
SRC_CHICK
B:
[3-257]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
-
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
-----------------
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
255
Blastp_CBE
48.87
44%
-7
- C2 -
-
3QRK
1
ABL1_HUMAN
A:
[9-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
---------
401
Blastp_CBE
48.85
46%
-68
- C2 -
-
3QLF
1
SRC_CHICK
B:
[11-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
----
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
----------------------
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
333
Blastp_CBE
48.84
47%
-67
- C2 -
-
1YOL
1
SRC_HUMAN
B:
[9-262]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
G
-
E
-
T
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
---------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
----------------
300
Blastp_CBE
48.81
44%
-9
- C2 -
-
2HYY
1
ABL1_HUMAN
A:
[8-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
-
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
519
Blastp_CBE
48.78
40%
-37
- C2 -
-
6FNF
1
A:
[13-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
H
P
S
C
V
T
--------
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
--
K
T
K----
E
---
V
-
P
-
V
A
I
K
T
L
K
A
G
Y
--
T
---
E
K
Q
RV
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
-
D
-
G
--
E
-
F
S
-
V
-
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
-----------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
--
311
Blastp_CBE
48.72
44%
-11
- C2 -
-
2F4J
1
ABL1_HUMAN
A:
[5-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
P
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
229
Blastp_CBE
48.73
45%
-6
- C2 -
-
3MSS
2
ABL1_MOUSE
D:
[6-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
-----------
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
268
Blastp_CBE
48.72
47%
-78
- C2 -
-
6HVF
3
?
A:
[10-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
-----------------
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
505
Blastp_CBE
48.70
40%
-38
- C2 -
-
6Q7D
1
?
A:
[13-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
H
P
S
C
V
T
--------
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
--
K
T
K----
E
---
V
-
P
-
V
A
I
K
T
L
K
A
G
Y
--
T
---
E
K
Q
RV
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
-
D
-
G
--
E
-
F
S
-
V
-
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
-----------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
--
304
Blastp_CBE
48.68
44%
-6
- C2 -
-
2G2I
1
ABL1_HUMAN
A:
[6-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
---
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
P
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
455
Blastp_CBE
48.60
46%
-67
- C2 -
-
4MCV
1
SRC_CHICK
A:
[3-257]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
406
Blastp_CBE
48.61
44%
-4
- C2 -
-
6BL8
1
ABL1_HUMAN
A:
[1-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
F
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
233
Blastp_CBE
48.65
45%
-8
- C2 -
-
3MS9
2
ABL1_MOUSE
B:
[9-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
---
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
262
Blastp_CBE
48.61
44%
-13
- C2 -
-
2HZI
1
ABL1_HUMAN
B:
[10-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
------
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
334
Blastp_CBE
48.60
47%
-65
- C2 -
-
1YOL
1
SRC_HUMAN
A:
[6-262]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
G
-
E
-
T
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
---------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
----------------
216
Blastp_CBE
48.59
47%
-76
- C2 -
-
3F3U
1
SRC_CHICK
B:
[10-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
-------
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
524
Blastp_CBE
48.58
40%
-19
- C2 -
-
5NKE
1
A:
[13-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
H
P
S
C
V
T
--------
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
--
K
T
SSGKK
E
---
V
-
P
-
V
A
I
K
T
L
K
A
G
Y
--
T
---
E
K
Q
RV
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
-
D
-
G
--
E
-
F
S
-
V
-
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
D
PEA
T
Y
--
T
T
-
S
-
G
G
K
-
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
--
363
Blastp_CBE
48.57
47%
-65
- C2 -
-
3UQG
1
SRC_CHICK
B:
[9-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
----
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
---------
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
397
Blastp_CBE
48.55
44%
-9
- C2 -
-
3QRJ
1
ABL1_HUMAN
B:
[11-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
--------
526
Fugue
48.46
47%
-40
- C2 -
-
1BYG
1
CSK_HUMAN
A:
[15-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
W
A
L
N
M
K
E
L
K
--------
L
L
Q
T
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
RG-----------
N
-
K
-
V
A
V
K
C
I
K
-----
N
---
D
A
Q
--
A
F
L
A
E
A
S
V
M
T
Q
L
R
H
S
N
L
V
Q
L
L
G
V
I
V
--E
E
G
-
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
S
-
R
-
G
--RS
V
-
L
G
-
G
-
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
E
D
N
V
A
K
V
S
D
F
G
----------------------
L
-
L
P
V
K
W
T
A
P
E
A
L
R
E
K
K
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
R
V
P
Y
P
R
I
P
L-
K
D
V
V
P
R
V
E
K
G
Y
K
M
D
A
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
Q
L
E
H
I
K
T
H
E
L
----
324
Blastp_CBE
48.45
47%
-68
- C2 -
-
4MXX
1
SRC_HUMAN
B:
[11-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
T
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
T
D
F
G
L
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
----------------
402
Blastp_CBE
48.38
46%
-82
- C2 -
-
3QLF
1
SRC_CHICK
A:
[11-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
----------------
L
Q
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
-------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
434
Blastp_CBE
48.43
44%
-9
- C2 -
-
4TWP
1
ABL1_HUMAN
A:
[1-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
----------
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
393
Blastp_CBE
48.37
44%
-13
- C2 -
-
3DK3
1
ABL1_MOUSE
B:
[4-269]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
------
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
F
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
386
Blastp_CBE
48.41
47%
-15
- C2 -
-
3HMI
1
ABL2_HUMAN
A:
[25-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
-
P
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
E
--
E
-
V
T
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
-----------------
298
Blastp_CBE
48.38
44%
-4
- C2 -
-
2HYY
1
ABL1_HUMAN
C:
[6-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
-
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
------
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
250
Blastp_CBE
48.37
45%
-4
- C2 -
-
3KFA
1
ABL1_MOUSE
A:
[4-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
339
Blastp_CBE
48.31
44%
-7
- C2 -
-
3IK3
1
ABL1_MOUSE
A:
[4-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---------
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
517
Blastp_CBE
48.32
40%
-19
- C2 -
-
6FNH
11
EPHA2_HUMAN
A:
[13-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
H
P
S
C
V
T
--------
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
--
K
T
SGKK-
E
---
V
-
P
-
V
A
I
K
T
L
K
A
G
Y
--
T
---
E
K
Q
RV
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
-
D
-
G
--
E
-
F
S
-
V
-
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
--------------
G
K
-
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
--
261
Blastp_CBE
48.31
44%
-3
- C2 -
-
3CS9
1
ABL1_HUMAN
A:
[10-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
---------
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
511
Blastp_CBE
48.22
40%
-34
- C2 -
-
6HEV
1
A:
[13-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
H
P
S
C
V
T
--------
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
----KK---
E
---
V
-
P
-
V
A
I
K
T
L
K
A
G
Y
--
T
---
E
K
Q
RV
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
-
D
-
G
--
E
-
F
S
-
V
-
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
----------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
--
287
Blastp_CBE
48.29
44%
-8
- C2 -
-
3UE4
1
ABL1_HUMAN
A:
[8-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
251
Blastp_CBE
48.28
45%
-13
- C2 -
-
3KF4
1
ABL1_MOUSE
B:
[4-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
---
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
256
Blastp_CBE
48.24
44%
-7
- C2 -
-
3QRI
1
ABL1_HUMAN
B:
[10-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
----------
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
512
Blastp_CBE
48.23
40%
-36
- C2 -
-
6HEU
1
A:
[13-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
H
P
S
C
V
T
--------
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
--
K
T
K----
E
---
V
-
P
-
V
A
I
K
T
L
K
A
G
Y
--
T
---
E
K
Q
RV
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
-
D
-
G
--
E
-
F
S
-
V
-
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
-----------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
--
408
Blastp_CBE
48.22
46%
-72
- C2 -
-
1YOM
1
SRC_HUMAN
A:
[5-262]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----------------------
A
----------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
G
-
E
-
T
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
----------------
522
Blastp_CBE
48.12
40%
-16
- C2 -
-
5NKG
1
A:
[13-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
H
P
S
C
V
T
--------
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
--
K
T
SSGKK
E
---
V
-
P
-
V
A
I
K
T
L
K
A
G
Y
--
T
---
E
K
Q
RV
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
-
D
-
G
--
E
-
F
S
-
V
-
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
D
PEA
T
Y
--
T
T
-
S
-
G
G
K
-
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
--
301
Blastp_CBE
48.20
44%
0
- C2 -
-
2HIW
1
ABL1_HUMAN
B:
[6-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
222
Blastp_CBE
48.17
47%
-82
- C2 -
-
2HWP
1
SRC_CHICK
A:
[9-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------
K
D
A
W
E
I
P
R
E
S
L
R
----------
V
K
L
G
Q
G
C
-
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
-----------------
F
L
Q
-
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
-------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
303
Blastp_CBE
48.14
44%
-12
- C2 -
-
2G2I
1
ABL1_HUMAN
B:
[7-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
----
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
P
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
521
Blastp_CBE
48.12
40%
-20
- C2 -
-
5NKH
1
A:
[13-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
H
P
S
C
V
T
--------
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
--
K
T
SSGKK
E
---
V
-
P
-
V
A
I
K
T
L
K
A
G
Y
--
T
---
E
K
Q
RV
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
-
D
-
G
--
E
-
F
S
-
V
-
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
D
PEA
T
Y
--
T
T
-
S
-
G
G
K
-
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
--
380
Blastp_CBE
48.09
47%
-65
- C2 -
-
3EL7
1
SRC_CHICK
A:
[10-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
-
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-----
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
235
Blastp_CBE
48.06
45%
-8
- C2 -
-
3K5V
2
ABL1_MOUSE
B:
[9-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
-----
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
299
Blastp_CBE
48.02
44%
-6
- C2 -
-
2HYY
1
ABL1_HUMAN
B:
[6-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
-
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
405
Blastp_CBE
47.97
44%
-6
- C2 -
-
6BL8
1
ABL1_HUMAN
B:
[1-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
---
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
F
--
T
A
-
H
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
231
Blastp_CBE
48.02
45%
-8
- C2 -
-
3MSS
2
ABL1_MOUSE
B:
[6-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
-----------
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
282
Blastp_CBE
47.97
47%
-73
- C2 -
-
2QQ7
1
SRC_CHICK
A:
[10-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
-
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
------------------
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
---------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
204
Blastp_CBE
47.94
52%
-10
- C2 -
-
4UEU
1
?
A:
[3-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
D
K
W
E
I
P
R
S
E
I
T
--------
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
--
R
N
Y----
N
---
I
-
E
-
V
A
V
K
T
L
K
E
G
T
--
M
---
S
V
E
--
E
F
L
Q
E
A
Q
I
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
T
K
E
-
P
P
-
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
-
C
-
E
-
G
--
H
T
V
N
-
A
-
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
V
K
V
A
D
F
G
L
A
R
L
I
----------------
A
K
-
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
-
G
S
E
V
I
E
Q
V
E
R
G
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
---------
319
Blastp_CBE
47.87
44%
-8
- C2 -
-
6NPU
2
ABL1_HUMAN
A:
[18-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
----------
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
501
Blastp_CBE
47.86
45%
-30
- C2 -
-
3D7T
1
CSK_HUMAN
A:
[7-262]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
A
L
N
M
K
E
L
K
--------
L
L
Q
T
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
--
R
G
-----
N
-----
K
-
V
A
V
K
C
I
K
N
D
A
--
T
---
A
Q
A
---
F
L
A
E
A
S
V
M
T
Q
L
R
H
S
N
L
V
Q
L
L
G
V
I
V
E
E
-
K
G
G
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
S
-
R
G
R
-
S
--
V
-
L
G
-
G
-
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
E
D
N
V
A
K
V
S
D
F
G
-------------------------
P
V
K
W
T
A
P
E
A
L
R
E
A
A
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
R
V
P
Y
P
R
I
P
-
L
K
D
V
V
P
R
V
E
K
G
Y
K
M
D
A
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
Q
L
E
H
I
---------
484
Blastp_CBE
47.85
44%
-7
- C2 -
-
3DK7
1
ABL1_MOUSE
A:
[4-269]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
---------
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
518
Blastp_CBE
47.84
40%
-30
- C2 -
-
6FNG
7
A:
[13-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
H
P
S
C
V
T
--------
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
----KK---
E
---
V
-
P
-
V
A
I
K
T
L
K
A
G
Y
--
T
---
E
K
Q
RV
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
-
D
-
G
--
E
-
F
S
-
V
-
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
---------------------
K
-
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
--
230
Blastp_CBE
47.83
45%
-4
- C2 -
-
3MSS
2
ABL1_MOUSE
C:
[6-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
-----------
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
266
Blastp_CBE
47.79
44%
-5
- C2 -
-
5HU9
14
ABL1_HUMAN
A:
[8-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
---------------
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
516
Blastp_CBE
47.78
40%
-18
- C2 -
-
6FNH
6
EPHA2_HUMAN
B:
[13-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
H
P
S
C
V
T
--------
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
--
K
T
SK---
E
---
V
-
P
-
V
A
I
K
T
L
K
A
G
Y
--
T
---
E
K
Q
RV
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
-
D
-
G
--
E
-
F
S
-
V
-
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
D
PEA-----------
K
-
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
--
523
Blastp_CBE
47.77
40%
-6
- C2 -
-
5NKF
1
A:
[13-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
H
P
S
C
V
T
--------
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
--
K
T
SGKK-
E
---
V
-
P
-
V
A
I
K
T
L
K
A
G
Y
--
T
---
E
K
Q
RV
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
-
D
-
G
--
E
-
F
S
-
V
-
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
D
PEA
T
Y
--
T
T
-
S
-
G
G
K
-
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
--
227
Blastp_CBE
47.76
45%
-9
- C2 -
-
6HD4
2
ABL1_MOUSE
B:
[9-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
-----
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
398
Blastp_CBE
47.74
44%
-15
- C2 -
-
3QRJ
1
ABL1_HUMAN
A:
[12-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
----------
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
---------
388
Blastp_CBE
47.68
47%
-25
- C2 -
-
2XYN
4
ABL2_HUMAN
C:
[27-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
--
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
-
P
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
E
--
E
-
V
T
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
-----------------
203
Blastp_CBE
47.72
42%
-8
- C2 -
-
4XEY
1
ABL1_HUMAN
A:
[116-383]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N---------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
----
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
451
Blastp_CBE
47.70
45%
-11
- C2 -
-
3DK6
1
ABL1_MOUSE
A:
[4-269]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
--
G
Q
F
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
----------
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
326
Blastp_CBE
47.68
47%
-72
- C2 -
-
6ATE
1
SRC_HUMAN
A:
[10-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
-----------
P
E
--
A
F
--
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
T
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
---------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
----------------
269
Blastp_CBE
47.67
47%
-76
- C2 -
-
6HVE
1
?
B:
[11-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
------------------
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
264
Blastp_CBE
47.62
44%
-12
- C2 -
-
4ZOG
2
ABL1_HUMAN
B:
[6-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
---
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
234
Blastp_CBE
47.62
45%
-4
- C2 -
-
3MS9
2
ABL1_MOUSE
A:
[9-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
-----------
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
482
Blastp_CBE
47.60
44%
-43
- C2 -
-
3KMM
1
LCK_HUMAN
A:
[15-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
E
V
P
R
E
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
G
-----
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
--
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
--
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
-
S
-
G
I-
K
-
L
T
-
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
-
L
I
E
D
---
N
E
--
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
-
D
Y
L
R
S
V
L
E
----------
373
Blastp_CBE
47.55
47%
-69
- C2 -
-
3EN7
1
SRC_CHICK
A:
[9-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
---
G
E
V
W
M
G
T
W
--
N
----------
T
-
R
-
V
A
I
K
T
L
K
P
--------------
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
278
Blastp_CBE
47.52
47%
-78
- C2 -
-
3LOK
1
SRC_CHICK
A:
[10-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
---
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
-------------------
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
---------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
232
Blastp_CBE
47.48
45%
-4
- C2 -
-
3MSS
2
ABL1_MOUSE
A:
[6-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
-----------
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
509
Blastp_CBE
47.47
40%
-29
- C2 -
-
6HEX
1
A:
[13-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
H
P
S
C
V
T
--------
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
----KK---
E
---
V
-
P
-
V
A
I
K
T
L
K
A
G
Y
--
T
---
E
K
Q
RV
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
-
D
-
G
--
E
-
F
S
-
V
-
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
--
295
Blastp_CBE
47.44
44%
-3
- C2 -
-
2HZ4
1
ABL1_HUMAN
B:
[6-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
-----
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
357
Blastp_CBE
47.43
47%
-73
- C2 -
-
4FIC
1
SRC_CHICK
B:
[11-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
---------------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
510
Blastp_CBE
47.36
40%
-26
- C2 -
-
6HEW
1
A:
[13-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
H
P
S
C
V
T
--------
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
----KK---
E
---
V
-
P
-
V
A
I
K
T
L
K
A
G
Y
--
T
---
E
K
Q
RV
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
-
D
-
G
--
E
-
F
S
-
V
-
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
-------------------
G
K
-
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
--
275
Blastp_CBE
47.28
47%
-76
- C2 -
-
5D10
1
SRC_CHICK
B:
[10-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
--------------------
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
310
Blastp_CBE
47.26
44%
-12
- C2 -
-
2E2B
1
ABL1_HUMAN
A:
[9-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
------
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
-------
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
248
Blastp_CBE
47.28
45%
-6
- C2 -
-
3OXZ
1
ABL1_MOUSE
A:
[4-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
-----------
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
----------------
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
225
Blastp_CBE
47.26
45%
-9
- C2 -
-
6HD6
1
ABL1_MOUSE
B:
[9-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
-----
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
277
Blastp_CBE
47.22
47%
-82
- C2 -
-
3LOK
1
SRC_CHICK
B:
[11-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
----------------------
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
221
Blastp_CBE
47.21
47%
-87
- C2 -
-
2HWP
1
SRC_CHICK
B:
[11-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
---
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
---------------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
---------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
390
Blastp_CBE
47.19
47%
-23
- C2 -
-
2XYN
2
ABL2_HUMAN
A:
[26-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
--
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
-
P
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
E
--
E
-
V
T
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
-----------------
309
Blastp_CBE
47.09
44%
-10
- C2 -
-
2E2B
1
ABL1_HUMAN
B:
[9-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
----------
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---------
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
--------
374
Blastp_CBE
47.07
47%
-84
- C2 -
-
3EN6
1
SRC_CHICK
B:
[10-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
--
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
--------------------
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
------
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
---------------------------
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
483
Blastp_CBE
46.99
44%
-12
- C2 -
-
3DK7
1
ABL1_MOUSE
B:
[4-269]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
------
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
307
Blastp_CBE
46.97
44%
-0
- C2 -
-
2G2F
1
ABL1_HUMAN
B:
[9-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
-----
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
P
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
237
Blastp_CBE
46.95
45%
-4
- C2 -
-
2HZN
1
ABL1_MOUSE
A:
[9-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
---
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
--
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
223
Blastp_CBE
46.89
47%
-76
- C2 -
-
2HWO
2
SRC_CHICK
B:
[11-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
--------------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
458
Blastp_CBE
46.82
46%
-68
- C2 -
-
4LGH
1
SRC_CHICK
A:
[2-256]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
--
N
G
---------
T
-
R
-
V
A
I
K
T
L
-------------------
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
520
Blastp_CBE
46.78
40%
-25
- C2 -
-
5NKI
1
A:
[13-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
H
P
S
C
V
T
--------
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
----KK---
E
---
V
-
P
-
V
A
I
K
T
L
K
A
G
Y
--
T
---
E
K
Q
RV
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
-
D
-
G
--
E
-
F
S
-
V
-
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
-------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
--
469
Blastp_CBE
46.76
44%
-41
- C2 -
-
3AC2
3
LCK_HUMAN
A:
[12-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
E
V
P
R
E
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
G
-----
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
--
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
--
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
-
S
-
G
I-
K
-
L
T
-
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
-
L
I
E
D
---
N
E
--
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
-
D
Y
L
R
S
V
L
E
----------
514
Blastp_CBE
46.75
40%
-27
- C2 -
-
6HES
2
A:
[13-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
H
P
S
C
V
T
--------
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
----KK---
E
---
V
-
P
-
V
A
I
K
T
L
K
A
G
Y
--
T
---
E
K
Q
RV
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
-
D
-
G
--
E
-
F
S
-
V
-
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
-----------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
--
472
Blastp_CBE
46.72
44%
-39
- C2 -
-
2ZM4
2
LCK_HUMAN
A:
[12-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
E
V
P
R
E
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
G
-----
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
--
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
--
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
-
S
-
G
I-
K
-
L
T
-
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
-
L
I
E
D
---
N
E
--
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
-
D
Y
L
R
S
V
L
E
----------
476
Blastp_CBE
46.71
44%
-39
- C2 -
-
2OFU
1
LCK_HUMAN
A:
[8-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
E
V
P
R
E
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
G
-----
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
--
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
--
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
-
S
-
G
I-
K
-
L
T
-
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
-
L
I
E
D
---
N
E
--
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
-
D
Y
L
R
S
V
L
E
----------
463
Blastp_CBE
46.62
44%
-39
- C2 -
-
3ACK
2
LCK_HUMAN
A:
[12-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
E
V
P
R
E
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
G
-----
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
--
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
--
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
-
S
-
G
I-
K
-
L
T
-
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
-
L
I
E
D
---
N
E
--
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
-
D
Y
L
R
S
V
L
E
----------
466
Blastp_CBE
46.61
44%
-38
- C2 -
-
3AC5
2
LCK_HUMAN
A:
[12-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
E
V
P
R
E
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
G
-----
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
--
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
--
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
-
S
-
G
I-
K
-
L
T
-
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
-
L
I
E
D
---
N
E
--
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
-
D
Y
L
R
S
V
L
E
----------
457
Blastp_CBE
46.61
46%
-67
- C2 -
-
4LGH
1
B:
[3-256]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
-
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
-----------------
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
387
Blastp_CBE
46.67
47%
-6
- C2 -
-
3GVU
2
ABL2_HUMAN
A:
[23-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
----------------
M
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
-
P
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
E
--
E
-
V
T
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
---
G
D
---
T
Y
--
T
-----
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
-----------------
219
Blastp_CBE
46.64
47%
-71
- C2 -
-
2QLQ
1
SRC_CHICK
B:
[10-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
---------------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
271
Blastp_CBE
46.62
47%
-77
- C2 -
-
5D12
1
SRC_CHICK
B:
[11-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
------------
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
456
Blastp_CBE
46.61
46%
-50
- C2 -
-
2DQ7
1
X:
[4-256]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
R
E
S
L
Q
--------
L
I
K
R
L
G
N
G
Q
F
G
E
V
W
M
G
T
W
--
N
G
-----
N
---
T
-
K
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
S
F
L
E
E
A
Q
I
M
K
K
L
K
H
D
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
D
-
G
-
E
-
G
--
R
A
L
K
-
L
-
P
N
L
V
D
M
A
A
Q
V
A
A
G
M
A
Y
I
E
R
M
N
Y
I
H
R
D
L
R
S
A
N
I
L
V
G
N
G
L
I
C
K
I
A
D
F
G
L
A
R
-
L
I
E
D
---
N
E
--
T
A
-
R
Q
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
V
T
K
G
R
V
P
Y
P
G
M
N
-
N
R
E
V
L
E
Q
V
E
R
G
Y
R
M
P
C
P
Q
D
C
P
I
S
L
H
E
L
M
I
H
C
W
K
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
460
Blastp_CBE
46.57
44%
-40
- C2 -
-
3AD6
2
LCK_HUMAN
A:
[12-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
E
V
P
R
E
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
G
-----
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
--
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
--
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
-
S
-
G
I-
K
-
L
T
-
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
-
L
I
E
D
---
N
E
--
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
-
D
Y
L
R
S
V
L
E
----------
281
Blastp_CBE
46.56
47%
-71
- C2 -
-
2QQ7
1
SRC_CHICK
B:
[11-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
--------------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
395
Blastp_CBE
46.50
47%
-11
- C2 -
-
4XLI
1
B:
[1-256]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
----
G
E
V
Y
V
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
-
P
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
S
-
R
-
E
--
E
-
V
T
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
-----------------
499
Blastp_CBE
46.41
43%
-28
- C2 -
-
1BYG
1
CSK_HUMAN
A:
[15-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
W
A
L
N
M
K
E
L
K
--------
L
L
Q
T
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
--
R
G
-----
N
-----
K
-
V
A
V
K
C
I
K
N
D
-------
A
Q
A
---
F
L
A
E
A
S
V
M
T
Q
L
R
H
S
N
L
V
Q
L
L
G
V
I
V
E
E
---G
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
S
-
R
G
R
-
S
--
V
-
L
G
-
G
-
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
E
D
N
V
A
K
V
S
D
F
G
L
-----------------------
L
P
V
K
W
T
A
P
E
A
L
R
E
K
K
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
R
V
P
Y
P
R
I
P
-
L
K
D
V
V
P
R
V
E
K
G
Y
K
M
D
A
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
Q
L
E
H
I
---------
477
Blastp_CBE
46.39
44%
-47
- C2 -
-
1QPJ
1
LCK_HUMAN
A:
[6-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
E
V
P
R
E
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
G
-----
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
--
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
--
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
-
S
-
G
I-
K
-
L
T
-
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
-
L
I
E
D
---
N
E
--
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
-
D
Y
L
R
S
V
L
E
----------
468
Blastp_CBE
46.31
44%
-42
- C2 -
-
3AC3
1
LCK_HUMAN
A:
[12-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
E
V
P
R
E
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
G
-----
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
--
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
--
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
-
S
-
G
I-
K
-
L
T
-
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
-
L
I
E
D
---
N
E
--
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
-
D
Y
L
R
S
V
L
E
----------
376
Blastp_CBE
46.31
47%
-73
- C2 -
-
3EN5
1
SRC_CHICK
A:
[13-265]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
-
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
---------------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
----------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
462
Blastp_CBE
46.30
44%
-43
- C2 -
-
3AD4
3
LCK_HUMAN
A:
[12-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
E
V
P
R
E
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
G
-----
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
--
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
--
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
-
S
-
G
I-
K
-
L
T
-
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
-
L
I
E
D
---
N
E
--
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
-
D
Y
L
R
S
V
L
E
----------
478
Blastp_CBE
46.29
44%
-39
- C2 -
-
1QPE
1
LCK_HUMAN
A:
[6-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
E
V
P
R
E
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
G
-----
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
--
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
--
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
-
S
-
G
I-
K
-
L
T
-
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
-
L
I
E
D
---
N
E
--
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
-
D
Y
L
R
S
V
L
E
----------
267
Blastp_CBE
46.28
47%
-72
- C2 -
-
6HVF
2
?
B:
[11-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
-----------------
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
---------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
284
Blastp_CBE
46.24
44%
0
- C2 -
-
4YC8
3
ABL1_HUMAN
B:
[8-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
------
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
389
Blastp_CBE
46.22
47%
-20
- C2 -
-
2XYN
4
ABL2_HUMAN
B:
[26-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
--
D
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
-
P
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
E
--
E
-
V
T
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
-----------------
464
Blastp_CBE
46.06
44%
-39
- C2 -
-
3ACJ
2
LCK_HUMAN
A:
[12-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
E
V
P
R
E
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
G
-----
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
--
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
--
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
-
S
-
G
I-
K
-
L
T
-
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
-
L
I
E
D
---
N
E
--
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
-
D
Y
L
R
S
V
L
E
----------
471
Blastp_CBE
45.98
44%
-40
- C2 -
-
2ZYB
1
LCK_HUMAN
A:
[12-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
E
V
P
R
E
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
G
-----
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
--
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
--
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
-
S
-
G
I-
K
-
L
T
-
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
-
L
I
E
D
---
N
E
--
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
-
D
Y
L
R
S
V
L
E
----------
481
Blastp_CBE
45.85
44%
-36
- C2 -
-
3BYO
1
?
A:
[6-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
E
V
P
R
E
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
G
-----
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
--
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
--
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
-
S
-
G
I-
K
-
L
T
-
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
-
L
I
E
D
---
N
E
--
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
-
D
Y
L
R
S
V
L
E
----------
479
Blastp_CBE
45.91
44%
-39
- C2 -
-
1QPC
2
?
A:
[6-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
E
V
P
R
E
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
G
-----
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
--
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
--
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
-
S
-
G
I-
K
-
L
T
-
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
-
L
I
E
D
---
N
E
--
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
-
D
Y
L
R
S
V
L
E
----------
467
Blastp_CBE
45.87
44%
-37
- C2 -
-
3AC4
2
LCK_HUMAN
A:
[12-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
E
V
P
R
E
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
G
-----
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
--
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
--
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
-
S
-
G
I-
K
-
L
T
-
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
-
L
I
E
D
---
N
E
--
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
-
D
Y
L
R
S
V
L
E
----------
475
Blastp_CBE
45.85
44%
-35
- C2 -
-
3BYM
1
LCK_HUMAN
A:
[7-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
E
V
P
R
E
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
G
-----
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
--
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
--
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
-
S
-
G
I-
K
-
L
T
-
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
-
L
I
E
D
---
N
E
--
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
-
D
Y
L
R
S
V
L
E
----------
491
Blastp_CBE
45.81
44%
-35
- C2 -
-
1QPD
1
?
A:
[6-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
V
P
R
E
T
L
K
--------
L
V
E
R
L
G
A
G
Q
A
G
E
V
W
M
G
Y
Y
--
N
G
-----
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
--
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
--
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
-
S
-
G
I-
K
-
L
T
-
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
-
L
I
E
D
---
A
E
--
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
-
D
Y
L
R
S
V
L
E
----------
396
Blastp_CBE
45.72
47%
-16
- C2 -
-
4XLI
1
ABL2_MOUSE
A:
[1-256]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
K
---------
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
-
P
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
S
-
R
-
E
--
E
-
V
T
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
-----------------
474
Blastp_CBE
45.67
44%
-47
- C2 -
-
6PDJ
2
?
A:
[15-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
E
V
P
R
E
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
G
-----
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
--
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
--
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
-
S
-
G
I-
K
-
L
T
-
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
-
L
I
E
D
---
N
E
--
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
-
D
Y
L
R
S
V
L
E
----------
473
Blastp_CBE
45.56
44%
-41
- C2 -
-
2ZM1
2
LCK_HUMAN
A:
[12-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
E
V
P
R
E
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
G
-----
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
--
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
--
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
-
S
-
G
I-
K
-
L
T
-
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
-
L
I
E
D
---
N
E
--
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
-
D
Y
L
R
S
V
L
E
----------
504
Blastp_CBE
45.61
40%
-2
- C2 -
-
6Q7E
1
?
A:
[13-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
H
P
S
C
V
T
--------
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
--
K
T
-----
E
---
V
-
P
-
V
A
I
K
T
L
K
A
G
Y
--
T
---
E
K
Q
RV
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
-
D
-
G
--
E
-
F
S
-
V
-
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
--
470
Blastp_CBE
45.56
44%
-40
- C2 -
-
3AC1
3
LCK_HUMAN
A:
[12-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
E
V
P
R
E
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
G
-----
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
--
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
--
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
-
S
-
G
I-
K
-
L
T
-
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
-
L
I
E
D
---
N
E
--
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
-
D
Y
L
R
S
V
L
E
----------
276
Blastp_CBE
45.53
47%
-65
- C2 -
-
5D10
1
SRC_CHICK
A:
[11-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
--------
L
E
V
K
L
G
Q
----
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
----
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
---------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
285
Blastp_CBE
45.47
44%
-4
- C2 -
-
4YC8
3
ABL1_HUMAN
A:
[8-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
------
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
------
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
492
Blastp_CBE
45.38
48%
-63
- C2 -
-
4LGG
1
B:
[5-249]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
450
Blastp_CBE
45.38
45%
-6
- C2 -
-
3DK6
1
ABL1_MOUSE
B:
[5-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
-------
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
----------
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
S
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
259
Blastp_CBE
45.14
44%
-8
- C2 -
-
3CS9
1
ABL1_HUMAN
C:
[9-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
----------
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
-------------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
--------
461
Blastp_CBE
44.84
44%
-35
- C2 -
-
3AD5
3
LCK_HUMAN
A:
[12-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
E
V
P
R
E
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
G
-----
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
--
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
--
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
-
S
-
G
I-
K
-
L
T
-
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
-
L
I
E
D
---
N
E
--
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
-
D
Y
L
R
S
V
L
E
----------
318
Blastp_CBE
44.67
44%
-2
- C2 -
-
6NPU
5
ABL1_HUMAN
B:
[19-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
-----------
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
---------------------
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
513
Blastp_CBE
44.49
40%
2
- C2 -
-
6HET
1
A:
[13-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
H
P
S
C
V
T
--------
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
--
K
T
-----
E
---
V
-
P
-
V
A
I
K
T
L
K
A
G
Y
--
T
---
E
K
Q
RV
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
-
D
-
G
--
E
-
F
S
-
V
-
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
--
515
Blastp_CBE
44.45
40%
-4
- C2 -
-
6FNH
5
C:
[13-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
H
P
S
C
V
T
--------
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
--
K
T
GKK--
E
---
V
-
P
-
V
A
I
K
T
L
K
A
G
Y
--
T
---
E
K
Q
RV
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
-
D
-
G
--
E
-
F
S
-
V
-
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
--
322
Blastp_CBE
44.42
44%
-1
- C2 -
-
3PYY
3
ABL1_HUMAN
B:
[19-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
-----------
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
---------------------
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
320
Blastp_CBE
44.20
44%
-4
- C2 -
-
6NPE
3
ABL1_HUMAN
B:
[19-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
-----------
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
------------------------
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
316
Blastp_CBE
44.08
44%
1
- C2 -
-
6NPV
5
ABL1_HUMAN
B:
[19-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
-----------
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
---------------------
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
493
Blastp_CBE
43.99
48%
-64
- C2 -
-
4LGG
1
SRC_CHICK
A:
[9-249]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
--
N
G
-----
T
---
T
-
R
-
V
A
I
K
T
L
K
P
G
--------------
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
----
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
M
-
G
--
K
-
Y
L
-
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
----------------
503
Blastp_CBE
43.71
40%
6
- C2 -
-
6Q7F
1
?
A:
[13-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
H
P
S
C
V
T
--------
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
--
K
T
-----
E
---
V
-
P
-
V
A
I
K
T
L
K
A
G
Y
--
T
---
E
K
Q
RV
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
-
D
-
G
--
E
-
F
S
-
V
-
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
-------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
--
260
Blastp_CBE
43.67
44%
1
- C2 -
-
3CS9
1
ABL1_HUMAN
B:
[10-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
---
T
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
-------------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
312
Blastp_CBE
43.62
45%
-9
- C2 -
-
2HZ0
1
ABL1_HUMAN
B:
[4-269]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----------------
Y
D
K
W
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
------
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
K
T
L
------
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
------------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
---------
293
Blastp_CBE
40.66
44%
4
- C2 -
-
4WA9
1
ABL1_HUMAN
A:
[10-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
--------
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
K
Y----
S
---
L
-
T
-
V
A
V
---------------------------
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
----
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
-
Q
--
E
-
V
N
-
A
-
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
--
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
465
Blastp_CBE
34.03
44%
-39
- C2 -
-
3AC8
1
LCK_HUMAN
A:
[12-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
E
V
P
R
E
T
L
K
--------
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
G
-----
H
---
T
-
K
-
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
--
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
--
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
-
S
-
G
I-
K
-
L
T
-
I
-
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
-
L
I
E
D
---
N
E
--
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
-
D
Y
L
R
S
V
L
E
----------