@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : TOPK_HUMAN: (2020-09-23 )
MEGISNFKTPSKLSEKKKSVLCSTPTINIPASPFMQKLGFGTGVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILKSLHHPNIVGYRAFTEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVALNMARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMTVTDPEACYIGTEPWKPKEAVEENGVITDKADIFAFGLTLWEMMTLSIPHINLSNDDDDEDKTFDESDFDDEAYYAALGTRPPINMEELDESYQKVIELFSVCTNEDPKDRPSAAHIVEALETDV
Atome Classification :
(20 SA)
----------------------------.........10........20.......------.30.....---...40........50........60........70.---.......80........90.-.-......100......-.110.....--..120.......130.......140.......150......--.160.--.......170.....-.-.--180........190.......200---.........210.......220---..-.......230.......240-.......250.......260.......270--------.------........280.--......290........300.......310.......320
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
----------------------------MEGISNFK
T
P
S
K
L
S
E
K
K
K
S
VLCSTPTIN------IP
A
S
P
F
M
Q
---
K
LGFGTG
V
N
V
Y
L
M
KRSPRGLSHSPWA
V
K
KI
N
P
I
C
N
D
---
H
Y
R
S
V
Y
Q
K
R
L
M
D
E
A
K
I
L
K
S
L-H-HPNI
V
G
Y
R
A
F
TEAND-G
S
L
C
L
A
M
EY--GGE
K
S
L
N
D
L
I
E
E
R
Y
KASQDPF
P
A
A
I
I
L
K
V
A
L
N
M
A
R
G
L
K
Y
L
H
--
Q
E
-
K
K
--
L
L
HGDIKSS
N
V
V
I
K
G-D-
F
--
E
T
-
I
K
I
C
DVGVSLPLDENMTVT-----DPE
A
C
Y
IGTEPWK
P
K
E
A
V
EE-----NG-VITDK
A
D
I
F
A
F
G
L
T
L
W
E
M
M
T-LSIPHINLSNDDDDEDKTFDESDFDD
E
A
----------
Y
------
Y
A
ALGTRPPI
N
M
--
E
E
L
D
E
S
Y
Q
-
K
V
I
E
L
F
S
V
CTNEDPKDRP
S
A
A
H
I
V
E
A
L
ETDV
1
PsiBlast_PDB
92.59
99%
-86
- C1 -
-
5J0A
4
?
B:
[2-303]
----------------------------------------------
S
V
L
C
S
T
P
T
I
N
------
I
P
A
S
P
F
M
Q
---
K
L
G
F
G
T
G
V
N
V
Y
L
M
K
R
S
P
R
G
L
S
H
S
P
W
A
V
K
K
I
N
P
I
C
N
D
---
H
Y
R
S
V
Y
Q
K
R
L
M
D
E
A
K
I
L
K
S
L
-
H
-
H
P
N
I
V
G
Y
R
A
F
T
E
A
N
D
-
G
S
L
C
L
A
M
E
Y
--
G
G
E
K
S
L
N
D
L
I
E
E
R
Y
K
A
S
Q
D
P
F
P
A
A
I
I
L
K
V
A
L
N
M
A
R
G
L
K
Y
L
H
--
Q
E
-
K
K
--
L
L
H
G
D
I
K
S
S
N
V
V
I
K
G
-
D
-
F
--
E
T
-
I
K
I
C
D
V
G
V
S
L
P
L
D
E
N
M
E
V
T
-----
D
P
E
A
C
Y
I
G
T
E
P
W
K
P
K
E
A
V
E
E
-----
N
G
-
V
I
T
D
K
A
D
I
F
A
F
G
L
T
L
W
E
M
M
T
-
L
S
I
P
H
I
N
L
S
N
D
D
D
D
E
D
K
T
F
D
E
S
D
F
D
D
E
A
----------
Y
------
Y
A
A
L
G
T
R
P
P
I
N
M
--
E
E
L
D
E
S
Y
Q
-
K
V
I
E
L
F
S
V
C
T
N
E
D
P
K
D
R
P
S
A
A
H
I
V
E
A
L
E
A
--
21
Blastp_CBE
89.91
99%
-88
- C1 -
-
5J0A
3
TOPK_HUMAN
A:
[2-299]
--------------------------------------------------
S
T
P
T
I
N
------
I
P
A
S
P
F
M
Q
---
K
L
G
F
G
T
G
V
N
V
Y
L
M
K
R
S
P
R
G
L
S
H
S
P
W
A
V
K
K
I
N
P
I
C
N
D
---
H
Y
R
S
V
Y
Q
K
R
L
M
D
E
A
K
I
L
K
S
L
-
H
-
H
P
N
I
V
G
Y
R
A
F
T
E
A
N
D
-
G
S
L
C
L
A
M
E
Y
--
G
G
E
K
S
L
N
D
L
I
E
E
R
Y
K
A
S
Q
D
P
F
P
A
A
I
I
L
K
V
A
L
N
M
A
R
G
L
K
Y
L
H
--
Q
E
-
K
K
--
L
L
H
G
D
I
K
S
S
N
V
V
I
K
G
-
D
-
F
--
E
T
-
I
K
I
C
D
V
G
V
S
L
P
L
D
E
N
M
E
V
T
-----
D
P
E
A
C
Y
I
G
T
E
P
W
K
P
K
E
A
V
E
E
-----
N
G
-
V
I
T
D
K
A
D
I
F
A
F
G
L
T
L
W
E
M
M
T
-
L
S
I
P
H
I
N
L
S
N
D
D
D
D
E
D
K
T
F
D
E
S
D
F
D
D
E
A
----------
Y
------
Y
A
A
L
G
T
R
P
P
I
N
M
--
E
E
L
D
E
S
Y
Q
-
K
V
I
E
L
F
S
V
C
T
N
E
D
P
K
D
R
P
S
A
A
H
I
V
E
A
L
E
T
--
51
HHSearch
89.77
100%
-88
- C1 -
-
5J0A
3
TOPK_HUMAN
A:
[3-299]
---------------------------------------------------
T
P
T
I
N
------
I
P
A
S
P
F
M
Q
---
K
L
G
F
G
T
G
V
N
V
Y
L
M
K
R
S
P
R
G
L
S
H
S
P
W
A
V
K
K
I
N
P
I
C
N
D
---
H
Y
R
S
V
Y
Q
K
R
L
M
D
E
A
K
I
L
K
S
L
-
H
-
H
P
N
I
V
G
Y
R
A
F
T
E
A
N
D
-
G
S
L
C
L
A
M
E
Y
--
G
G
E
K
S
L
N
D
L
I
E
E
R
Y
K
A
S
Q
D
P
F
P
A
A
I
I
L
K
V
A
L
N
M
A
R
G
L
K
Y
L
H
--
Q
E
-
K
K
--
L
L
H
G
D
I
K
S
S
N
V
V
I
K
G
-
D
-
F
--
E
T
-
I
K
I
C
D
V
G
V
S
L
P
L
D
E
N
M
E
V
T
-----
D
P
E
A
C
Y
I
G
T
E
P
W
K
P
K
E
A
V
E
E
-----
N
G
-
V
I
T
D
K
A
D
I
F
A
F
G
L
T
L
W
E
M
M
T
-
L
S
I
P
H
I
N
L
S
N
D
D
D
D
E
D
K
T
F
D
E
S
D
F
D
D
E
A
----------
Y
------
Y
A
A
L
G
T
R
P
P
I
N
M
--
E
E
L
D
E
S
Y
Q
-
K
V
I
E
L
F
S
V
C
T
N
E
D
P
K
D
R
P
S
A
A
H
I
V
E
A
L
E
T
--
62
HHSearch
58.83
23%
-94
- C1 -
-
4G3F
1
A:
[59-313]
----------------------------------------------------------------
W
M
T
H
Q
P
---
R
V
G
R
G
S
F
G
E
V
H
R
M
K
D
K
Q
T
---
G
F
Q
C
A
V
K
K
V
R
L
E
V
-------------
F
R
V
E
E
L
V
A
C
A
G
L
-
S
-
S
P
R
I
V
P
L
Y
G
A
V
R
E
-
G
-
P
W
V
N
I
F
M
E
L
--
L
E
G
G
S
L
G
Q
L
I
K
Q
M
-----
G
C
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
--
T
--
R
R
--
I
L
H
G
D
V
K
A
D
N
V
L
L
S
S
-
D
-
G
--
S
R
-
A
A
L
C
D
F
G
H
A
L
C
L
---------------
D
Y
I
P
G
T
E
T
H
M
A
P
E
V
V
M
G
------
K
-
P
C
D
A
K
V
D
I
W
S
S
C
C
M
M
L
H
M
L
N
-
G
C
H
P
W
T
Q
Y
F
R
G
P
----
L
----------
C
----------
L
------
K
I
-
A
S
E
P
P
P
I
R
---
E
I
P
P
S
C
A
P
-
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
V
H
R
A
S
A
M
E
L
R
R
K
V
G
K
--
70
HHSearch
58.36
25%
-82
- C1 -
-
4YFI
1
TNI3K_HUMAN
C:
[60-321]
--------------------------------------------------------------
L
S
E
I
E
F
H
E
---
I
I
G
S
G
S
F
G
K
V
Y
K
G
R
C
R
-----
N
K
I
V
A
I
K
R
Y
R
------------
S
D
V
D
M
F
C
R
E
V
S
I
L
C
Q
L
-
N
-
H
P
C
V
I
Q
F
V
G
A
C
L
N
D
P
-
S
Q
F
A
I
V
T
Q
Y
--
I
S
G
G
S
L
F
S
L
L
H
E
Q
K
----
R
I
L
D
L
Q
S
K
L
I
I
A
V
D
V
A
K
G
M
E
Y
L
H
--
N
L
T
Q
P
--
I
I
H
R
D
L
N
S
H
N
I
L
L
Y
E
-
D
-
G
---
H
-
A
V
V
A
D
F
G
E
S
R
F
L
Q
S
-----------------
G
N
L
R
W
M
A
P
E
V
F
T
Q
-----
C
T
-
R
Y
T
I
K
A
D
V
F
S
Y
A
L
C
L
W
E
I
L
T
-
G
E
I
P
F
A
H
L
K
P
A
A
---
A
D
-------
M
D
M
A
----------
Y
------
H
---
H
I
R
P
P
I
G
------
Y
S
I
P
K
-
P
I
S
S
L
L
I
R
G
W
N
A
C
P
E
G
R
P
E
F
S
E
V
V
M
K
L
E
E
--
68
HHSearch
58.34
22%
-71
- C1 -
-
4HZS
-
ACK1_HUMAN
B:
[122-387]
-------------------------------------------------------
G
------
E
K
D
L
R
L
L
E
---
K
L
G
D
G
S
F
G
V
V
R
R
G
E
W
D
A
P
S
G
K
T
V
S
V
A
V
K
C
L
K
P
D
V
L
S
-----
Q
P
E
A
M
D
D
F
I
R
E
V
N
A
M
H
S
L
-
D
-
H
R
N
L
I
R
L
Y
G
V
V
L
T
---
P
P
M
K
M
V
T
E
L
--
A
P
L
G
S
L
L
D
R
L
R
K
H
----
Q
G
H
F
L
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
--
S
--
K
R
--
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
-
R
-
D
---
L
-
V
K
I
G
D
F
G
L
M
R
A
L
P
------------------
V
P
F
A
W
C
A
P
E
S
L
K
T
------
R
-
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
W
I
G
L
N
G
S
Q
----
I
L
-------
H
-
K
----------
I
------
D
-
K
E
G
E
R
L
P
R
------
P
E
D
C
P
Q
-
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
R
D
F
L
L
E
--
65
HHSearch
56.68
21%
-75
- C1 -
-
2QOC
2
A:
[14-277]
-------------------------------------------------------
D
------
A
T
N
I
S
I
D
K
---
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
P
S
K
K
E
I
S
V
A
I
K
T
L
K
V
G
Y
-------
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
-
D
-
H
P
N
I
I
R
L
E
G
V
V
T
K
-
S
-
K
P
V
M
I
V
T
E
Y
--
M
E
N
G
S
L
D
S
F
L
R
K
H
D
----
A
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
--
D
--
M
G
--
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
-
N
-
L
---
V
-
C
K
V
S
D
F
G
L
S
R
V
L
E
D
----------------
K
I
P
I
R
W
T
S
P
E
A
I
A
Y
------
R
-
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
N
Q
D
----
V
----------
I
----------
K
------
A
V
D
E
G
Y
R
L
P
P
P
------
M
D
C
P
A
-
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
--
60
HHSearch
55.46
18%
-64
- C1 -
-
3C0I
1
CSKP_HUMAN
A:
[21-287]
------------------------------------------------------
L
F
------
E
D
V
Y
E
L
C
E
---
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
---
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
---
S
S
P
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
-
H
P
H
I
V
E
L
L
E
T
Y
S
S
-
D
-
G
M
L
Y
M
V
F
E
F
--
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
-
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
--
D
--
N
N
--
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
-
K
-
E
NS
A
P
-
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
L
--------
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
------
E
-
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
-
G
C
L
P
F
Y
G
T
K
E
R
L
----
F
---------
E
G
----------
I
--------
I
K
G
K
Y
K
M
N
P
---
R
Q
W
S
H
I
S
E
-
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
-----
59
HHSearch
54.65
18%
-64
- C1 -
-
3C0G
1
CSKP_HUMAN
B:
[21-287]
------------------------------------------------------
L
F
------
E
D
V
Y
E
L
C
E
---
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
---
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
---
S
S
P
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
-
H
P
H
I
V
E
L
L
E
T
Y
S
S
-
D
-
G
M
L
Y
M
V
F
E
F
--
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
-
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
--
D
--
N
N
--
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
-
K
-
E
NS
A
P
-
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
L
--------
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
------
E
-
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
-
G
C
L
P
F
Y
G
T
K
E
R
L
----
F
---------
E
G
----------
I
--------
I
K
G
K
Y
K
M
N
P
---
R
Q
W
S
H
I
S
E
-
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
-----
53
HHSearch
53.47
22%
-24
* C1 *
-
5WNL
1
RIPK4_MOUSE
A:
[18-285]
-------------------------------------------------------
D
------
A
G
E
F
A
G
W
E
---
K
V
G
S
G
G
F
G
Q
V
Y
K
V
R
H
V
H
W
---
K
T
W
L
A
I
K
C
S
P
---
V
------
D
D
R
E
R
M
E
L
L
E
E
A
K
K
M
E
M
A
-
K
-
F
R
Y
I
L
P
V
Y
G
I
C
Q
----
E
P
V
G
L
V
M
E
Y
--
M
E
T
G
S
L
E
K
L
L
A
S
------
E
P
L
P
W
D
L
R
F
R
I
V
H
E
T
A
V
G
M
N
F
L
H
CM
S
--
P
P
--
L
L
H
L
N
L
K
P
A
N
I
L
L
D
A
-
H
-
Y
---
H
-
V
K
I
S
D
F
G
L
A
K
C
-------------------
F
G
T
I
A
Y
L
P
P
E
R
I
R
E
-----
K
S
R
L
F
D
T
K
H
D
V
Y
S
F
A
I
V
I
W
G
V
L
T
-
Q
K
K
P
F
A
D
E
K
N
I
L
---
H
I
----------
M
----------
M
------
K
V
V
K
G
H
R
P
E
L
P
P
IC
R
P
R
P
R
A
C
A
-
S
L
I
G
L
M
Q
R
C
W
H
A
D
P
Q
V
R
P
T
F
Q
E
I
T
S
E
T
E
D
--
69
HHSearch
53.41
19%
-45
- C1 -
-
2WEL
7
KCC2D_HUMAN
A:
[4-265]
---------------------------------------------------------------
D
E
Y
Q
L
F
E
---
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
---
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
------
S
A
R
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
-
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
-
E
-
G
F
H
Y
L
V
F
D
L
--
V
T
G
G
E
L
F
E
D
I
V
A
R
-----
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
--
L
--
N
G
--
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
-
K
-
S
KG
A
A
-
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
D
Q
Q
--------
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
------
D
-
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
-
G
Y
P
P
F
W
D
E
D
Q
H
R
---------------
L
----------
Y
------
Q
Q
I
K
A
G
A
Y
D
F
P
S
--
P
E
W
D
T
V
T
P
-
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
-----
39
Fugue
53.02
21%
3
- C1 -
-
4DN5
7
M3K14_HUMAN
A:
[8-351]
SVEEYLVHALQGSVSSGQAHSLTSLAKT
W
A
A
R
G
S
R
S
R
E
P
S
P
K
T
E
D
N
E
G
V
L
L
T
E
K
L
K
PVDYEY
R
E
E
V
H
W
A
T
HQL
R
L
G
R
G
S
F
G
E
V
H
R
M
E
D
K
Q
T
G
---
F
Q
C
A
V
K
K
V
R
L
-------------
E
V
F
R
A
E
E
L
M
A
C
A
G
L
-
T
-
S
P
R
I
V
P
L
Y
G
A
V
R
E
G
P
--
W
V
N
I
F
M
E
L
--
L
E
G
G
S
L
G
Q
L
V
K
E
Q
-----
G
C
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
--
S
R
-
R
I
--
L
-
H
G
D
V
K
A
D
N
V
L
L
S
S
-
D
-
G
--
S
H
-
A
A
L
C
D
F
G
H
A
V
C
L
Q
----------------
I
P
G
T
E
T
H
M
A
P
E
V
V
L
G
-----
R
S
-
C
-
D
A
K
V
D
V
W
S
S
C
C
M
M
L
H
M
L
N
-
G
C
H
P
W
----------------
T
Q
F
F
R
G
P
----------
L
------
C
L
K
I
A
S
E
P
P
P
V
R
--
E
I
P
P
S
C
A
P
-
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
I
H
R
V
S
A
A
E
L
G
G
K
V
N
R
A
L
54
HHSearch
52.53
22%
-27
- C1 -
-
5WNJ
1
RIPK4_MOUSE
A:
[19-285]
--------------------------------------------------------------
A
G
E
F
A
G
W
E
---
K
V
G
S
--
F
G
Q
V
Y
K
V
R
H
V
H
W
---
K
T
W
L
A
I
K
C
S
P
S
L
H
V
------
D
D
R
E
R
M
E
L
L
E
E
A
K
K
M
E
M
A
-
K
-
F
R
Y
I
L
P
V
Y
G
I
C
Q
----
E
P
V
G
L
V
M
E
Y
--
M
E
T
G
S
L
E
K
L
L
A
S
------
E
P
L
P
W
D
L
R
F
R
I
V
H
E
T
A
V
G
M
N
F
L
H
CM
S
--
P
P
--
L
L
H
L
N
L
K
P
A
N
I
L
L
D
A
-
H
-
Y
---
H
-
V
K
I
S
D
F
G
L
A
K
C
-------------------
F
G
T
I
A
Y
L
P
P
E
R
I
R
E
-----
K
S
R
L
F
D
T
K
H
D
V
Y
S
F
A
I
V
I
W
G
V
L
T
-
Q
K
K
P
F
A
D
E
K
N
I
L
---
H
I
----------
M
----------
M
------
K
V
V
K
G
H
R
P
E
L
P
P
IC
R
P
R
P
R
A
C
A
-
S
L
I
G
L
M
Q
R
C
W
H
A
D
P
Q
V
R
P
T
F
Q
E
I
T
S
E
T
E
D
--
55
HHSearch
51.73
22%
-25
- C1 -
-
5WNI
1
RIPK4_MOUSE
A:
[19-285]
--------------------------------------------------------------
A
G
E
F
A
G
W
E
---
K
V
G
S
----
Q
V
Y
K
V
R
H
V
H
W
---
K
T
W
L
A
I
K
C
S
P
S
L
H
V
------
D
D
R
E
R
M
E
L
L
E
E
A
K
K
M
E
M
A
-
K
-
F
R
Y
I
L
P
V
Y
G
I
C
Q
----
E
P
V
G
L
V
M
E
Y
--
M
E
T
G
S
L
E
K
L
L
A
S
------
E
P
L
P
W
D
L
R
F
R
I
V
H
E
T
A
V
G
M
N
F
L
H
CM
S
--
P
P
--
L
L
H
L
N
L
K
P
A
N
I
L
L
D
A
-
H
-
Y
---
H
-
V
K
I
S
D
F
G
L
A
K
C
N
------------------
F
G
T
I
A
Y
L
P
P
E
R
I
R
E
-----
K
S
R
L
F
D
T
K
H
D
V
Y
S
F
A
I
V
I
W
G
V
L
T
-
Q
K
K
P
F
A
D
E
K
N
I
L
---
H
I
----------
M
----------
M
------
K
V
V
K
G
H
R
P
E
L
P
P
IC
R
P
R
P
R
A
C
A
-
S
L
I
G
L
M
Q
R
C
W
H
A
D
P
Q
V
R
P
T
F
Q
E
I
T
S
E
T
E
D
--
63
HHSearch
51.60
22%
-2
- C1 -
-
5TE0
10
AAK1_HUMAN
A:
[20-288]
----------------------------------------------------------------
Q
V
T
V
D
E
---
V
L
A
E
G
G
F
A
I
V
F
L
V
R
T
S
N
----
G
M
K
C
A
L
K
R
M
F
V
N
N
--------
E
H
D
L
Q
V
C
K
R
E
I
Q
I
M
R
D
L
-
S
G
H
K
N
I
V
G
Y
I
D
S
S
I
N
N
V
V
W
E
V
L
I
L
M
D
F
--
C
R
G
G
Q
V
V
N
L
M
N
Q
R
L
---
Q
T
G
F
T
E
N
E
V
L
Q
I
F
C
D
T
C
E
A
V
A
R
L
H
--
Q
--
C
K
TP
I
I
H
R
D
L
K
V
E
N
I
L
L
H
D
-
R
-
G
---
H
-
Y
V
L
C
D
F
G
S
A
T
N
K
F
Q
N
P
Q
T
E
GVNAV
E
D
E
I
K
K
Y
T
T
L
S
Y
R
A
P
E
M
V
N
L
YS---
G
K
-
I
I
T
T
K
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
Y
-
F
T
L
P
F
G
E
S
Q
V
A
----------------
I
----------
C
------
D
--
G
N
F
T
I
P
D
------
N
S
R
Y
S
Q
-
D
M
H
C
L
I
R
Y
M
L
E
P
D
P
D
K
R
P
D
I
Y
Q
V
S
Y
F
S
F
K
--
58
HHSearch
51.36
23%
-38
- C1 -
-
6MYN
1
B:
[74-327]
-----------------------------------------------------------------
M
T
H
Q
P
---
R
V
G
R
G
S
F
G
E
V
H
R
M
K
D
K
Q
T
---
G
F
Q
C
A
V
K
K
V
R
L
E
V
-------------
F
R
V
E
E
L
V
A
C
A
G
L
-
S
-
S
P
R
I
V
P
L
Y
G
A
V
R
E
-
G
-
P
W
V
N
I
F
M
E
L
--
L
E
G
G
S
L
G
Q
L
I
K
Q
M
-----
G
C
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
--
T
--
R
R
--
I
L
H
G
D
V
K
A
D
N
V
L
L
S
S
-
D
-
G
--
S
R
-
A
A
L
C
D
F
G
H
A
L
C
L
Q
P
D
G
L
G
K
SL---
L
T
G
D
Y
I
P
G
T
E
T
H
M
A
P
E
V
V
M
G
------
K
-
P
C
D
A
K
V
D
I
W
S
S
C
C
M
M
L
H
M
L
N
-
G
C
H
P
W
T
Q
Y
F
R
G
P
----
L
----------
C
----------
L
------
K
I
A
S
-
E
P
P
P
I
R
---
E
I
P
P
S
C
A
P
-
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
V
H
R
A
S
A
M
E
L
R
R
K
V
G
K
--
45
Fugue
51.35
15%
-38
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[18-338]
-----------------------------
K
E
L
Y
E
K
------------------------------
Y
M
I
A
E
---
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
S
---
S
K
K
T
Y
M
A
K
F
V
K
V
---------
K
G
T
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
A
-
R
-
H
R
N
I
L
H
L
H
E
S
F
E
S
M
E
-
E
L
V
M
I
F
E
F
I
--
S
G
L
D
I
F
E
R
I
N
T
S
A
F
-----
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
--
S
--
H
N
--
I
G
H
F
D
I
R
P
E
N
I
I
Y
Q
T
-
R
-
R
--
S
S
T
I
K
I
I
E
F
G
Q
A
R
Q
L
K
P
G
D
N
F
R
-----
L
L
F
----
T
A
P
E
Y
Y
A
P
E
V
H
Q
------
H
D
-
V
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
-
G
I
N
P
F
L
A
E
T
N
Q
Q
I
I
E
N
I
M
N
A
E
Y
T
F
D
E
E
A
FKEISIEAMD
F
------
V
D
R
L
L
V
K
E
R
K
S
R
--
M
T
A
S
E
A
L
Q
H
P
W
L
K
Q
K
I
E
R
V
S
T
K
V
I
R
T
L
K
H
R
R
Y
Y
H
T
L
I
K
K
D
67
HHSearch
49.81
18%
-1
- C1 -
-
2Y7J
1
PHKG2_HUMAN
A:
[93-360]
--------------------------------------------------------------
Y
Q
K
Y
D
P
K
D
---
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
---
G
H
E
F
A
V
K
I
M
E
V
T
A
E
R
LSP
E
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
-
H
P
H
I
I
T
L
I
D
S
Y
E
S
-
S
-
S
F
M
F
L
V
F
D
L
--
M
R
K
G
E
L
F
D
Y
L
T
E
K
-----
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
--
A
--
N
N
--
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
-
N
-
M
---
Q
-
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
---------
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
SMDET
H
P
-
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
-
G
S
P
P
F
W
H
R
R
Q
I
L
----
M
----------
L
----------
R
------
M
I
M
E
G
Q
Y
Q
F
-
S
S
--
P
E
W
D
D
R
S
S
-
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
-----
64
HHSearch
49.65
16%
-66
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[21-275]
--------------------------------------------------------------
Y
E
K
Y
M
I
A
E
---
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
S
S
---
K
K
T
Y
M
A
K
F
V
K
V
K
G
---------
T
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
A
-
R
-
H
R
N
I
L
H
L
H
E
S
F
E
S
-
M
-
E
E
L
V
M
I
F
E
F
--
I
S
G
L
D
I
F
E
R
I
N
T
S
A
----
F
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
--
S
--
H
N
--
I
G
H
F
D
I
R
P
E
N
I
I
Y
Q
T
-
R
R
S
--
S
T
-
I
K
I
I
E
F
G
Q
A
R
Q
L
K
P
G
D
---------
N
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
Q
H
------
D
-
V
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
-
G
I
N
P
F
L
A
E
T
N
Q
Q
----
I
----------
I
----------
E
------
N
I
M
N
-
A
E
Y
T
F
D
E
--
E
A
F
K
E
I
S
I
-
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
R
M
T
A
S
E
A
L
Q
H
-----
46
Fugue
46.80
17%
5
- C1 -
-
1KOB
1
?
A:
[23-374]
----------------------------
I
N
D
Y
D
K
F
Y
E
D
I
W
K
K
Y
V
P
Q
P
V
E
V
K
Q
G
S
V
Y
------
D
Y
-
Y
D
I
L
E
---
E
L
G
S
G
A
F
G
V
V
H
R
C
V
E
K
A
T
G
---
R
V
F
V
A
K
F
I
N
T
--------
P
Y
P
L
D
K
Y
T
V
K
N
E
I
S
I
M
N
Q
L
-
H
-
H
P
K
L
I
N
L
H
D
A
F
E
-
D
K
-
Y
E
M
V
L
I
L
E
F
LS
G
G
E
------
L
F
D
R
I
A
A
E
D
Y
K
M
S
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
--
E
--
H
S
--
I
V
H
L
D
I
K
P
E
N
I
M
C
E
T
K
K
-
A
--
S
S
-
V
K
I
I
D
F
G
L
A
T
K
L
N
P
D
E
I
V
K
-----
V
T
----
T
A
T
A
E
F
A
A
P
E
I
V
D
R
-----
E
P
--
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
-
G
L
S
P
F
A
G
E
D
D
L
E
T
L
Q
N
V
K
R
C
D
W
E
F
D
E
D
A
----------
F
SSVSPE
A
K
D
F
I
K
N
L
L
Q
K
E
--
P
R
K
R
L
T
V
H
-
D
A
L
E
H
P
W
L
K
G
D
H
S
N
L
T
S
R
I
P
S
S
R
Y
N
K
I
R
Q
K
I